Modification of Cognitive Performance in Schizophrenia by Complexin 2 Gene Polymorphisms
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Prioritization and Evaluation of Depression Candidate Genes by Combining Multidimensional Data Resources
Prioritization and Evaluation of Depression Candidate Genes by Combining Multidimensional Data Resources Chung-Feng Kao1, Yu-Sheng Fang2, Zhongming Zhao3, Po-Hsiu Kuo1,2,4* 1 Department of Public Health and Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, 2 Institute of Clinical Medicine, School of Medicine, National Cheng-Kung University, Tainan, Taiwan, 3 Departments of Biomedical Informatics and Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 4 Research Center for Genes, Environment and Human Health, National Taiwan University, Taipei, Taiwan Abstract Background: Large scale and individual genetic studies have suggested numerous susceptible genes for depression in the past decade without conclusive results. There is a strong need to review and integrate multi-dimensional data for follow up validation. The present study aimed to apply prioritization procedures to build-up an evidence-based candidate genes dataset for depression. Methods: Depression candidate genes were collected in human and animal studies across various data resources. Each gene was scored according to its magnitude of evidence related to depression and was multiplied by a source-specific weight to form a combined score measure. All genes were evaluated through a prioritization system to obtain an optimal weight matrix to rank their relative importance with depression using the combined scores. The resulting candidate gene list for depression (DEPgenes) was further evaluated by a genome-wide association (GWA) dataset and microarray gene expression in human tissues. Results: A total of 5,055 candidate genes (4,850 genes from human and 387 genes from animal studies with 182 being overlapped) were included from seven data sources. -
Transcriptional Regulation of RKIP in Prostate Cancer Progression
Health Science Campus FINAL APPROVAL OF DISSERTATION Doctor of Philosophy in Biomedical Sciences Transcriptional Regulation of RKIP in Prostate Cancer Progression Submitted by: Sandra Marie Beach In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences Examination Committee Major Advisor: Kam Yeung, Ph.D. Academic William Maltese, Ph.D. Advisory Committee: Sonia Najjar, Ph.D. Han-Fei Ding, M.D., Ph.D. Manohar Ratnam, Ph.D. Senior Associate Dean College of Graduate Studies Michael S. Bisesi, Ph.D. Date of Defense: May 16, 2007 Transcriptional Regulation of RKIP in Prostate Cancer Progression Sandra Beach University of Toledo ACKNOWLDEGMENTS I thank my major advisor, Dr. Kam Yeung, for the opportunity to pursue my degree in his laboratory. I am also indebted to my advisory committee members past and present, Drs. Sonia Najjar, Han-Fei Ding, Manohar Ratnam, James Trempe, and Douglas Pittman for generously and judiciously guiding my studies and sharing reagents and equipment. I owe extended thanks to Dr. William Maltese as a committee member and chairman of my department for supporting my degree progress. The entire Department of Biochemistry and Cancer Biology has been most kind and helpful to me. Drs. Roy Collaco and Hong-Juan Cui have shared their excellent technical and practical advice with me throughout my studies. I thank members of the Yeung laboratory, Dr. Sungdae Park, Hui Hui Tang, Miranda Yeung for their support and collegiality. The data mining studies herein would not have been possible without the helpful advice of Dr. Robert Trumbly. I am also grateful for the exceptional assistance and shared microarray data of Dr. -
Identification of Potential Key Genes and Pathway Linked with Sporadic Creutzfeldt-Jakob Disease Based on Integrated Bioinformatics Analyses
medRxiv preprint doi: https://doi.org/10.1101/2020.12.21.20248688; this version posted December 24, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. Identification of potential key genes and pathway linked with sporadic Creutzfeldt-Jakob disease based on integrated bioinformatics analyses Basavaraj Vastrad1, Chanabasayya Vastrad*2 , Iranna Kotturshetti 1. Department of Biochemistry, Basaveshwar College of Pharmacy, Gadag, Karnataka 582103, India. 2. Biostatistics and Bioinformatics, Chanabasava Nilaya, Bharthinagar, Dharwad 580001, Karanataka, India. 3. Department of Ayurveda, Rajiv Gandhi Education Society`s Ayurvedic Medical College, Ron, Karnataka 562209, India. * Chanabasayya Vastrad [email protected] Ph: +919480073398 Chanabasava Nilaya, Bharthinagar, Dharwad 580001 , Karanataka, India NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2020.12.21.20248688; this version posted December 24, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. Abstract Sporadic Creutzfeldt-Jakob disease (sCJD) is neurodegenerative disease also called prion disease linked with poor prognosis. The aim of the current study was to illuminate the underlying molecular mechanisms of sCJD. The mRNA microarray dataset GSE124571 was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened. -
Stand: November 2020
Stand: November 2020 Antragstellende beteiligte Bewillligung # Gemeinde / Kreis Aufgabenbereich Gemeinden vom Gemeindegruppe 1 Weiterstadt Darmstadt-Dieburg Erzhausen Standesamtsbezirk 25.09.2008 Beerfelden Hesseneck Haushalts- und 2 Mossautal Odenwald 25.09.2008 Rothenberg Rechnungswesen Sensbachtal Hünstetten Rheingau-Taunus- 3 Idstein Niedernhausen Standesamtsbezirk 26.11.2008 Kreis Waldems 4 Wahlsburg Kassel Oberweser Bauhof 11.03.2010 5 Groß-Umstadt Darmstadt-Dieburg Otzberg Errichtung eines Recyclinghofes 14.01.2009 Gemeinsames Beratungs- und Dienstleistungszentrum im Rheingau-Taunus- Rahmen der 6 Taunusstein 10 Gemeinden 02.09.2009 Kreis Haushaltswirtschaft auf der Grundlage der doppelten Buchführung Prüfung der elektrischen 7 Fuldatal Kassel 10 Gemeinden 26.11.2008 Anlagen und Betriebsmittel Sicherstellung des 8 Bischoffen Lahn-Dill-Kreis Hohenahr abwehrenden Brandschutzes 27.01.2009 und der allg. Hilfe 9 Kelkheim Main-Taunus-Kreis Eppstein Standesamtsbezirk 24.02.2009 Standesamtswesen, Kindergartenverwaltung, 10 Ebersburg Fulda Gersfeld 02.07.2009 Senioren- betreuung Fischbachtal 11 Reinheim Darmstadt-Dieburg Groß-Bieberau Werkstoffannahme 22.12.2009 Ober-Ramstadt 12 Mücke Vogelsbergkreis Gemünden Standesamtsbezirk 27.04.2009 (Felda) 13 Seligenstadt Offenbach Mainhausen Gemeinsames Personalamt 04.05.2009 Marburg- Cölbe 14 Wetter (Hessen) kommunale Jugendpflege 06.09.2009 Biedenkopf Lahntal Münchhausen Waldeck- Gemeinsame Steuer- und 15 Bromskirchen Allendorf (Eder) 27.04.2009 Frankenberg Personalverwaltung Antragstellende beteiligte -
Convergent Functional Genomics of Schizophrenia: from Comprehensive Understanding to Genetic Risk Prediction
Molecular Psychiatry (2012) 17, 887 -- 905 & 2012 Macmillan Publishers Limited All rights reserved 1359-4184/12 www.nature.com/mp IMMEDIATE COMMUNICATION Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction M Ayalew1,2,9, H Le-Niculescu1,9, DF Levey1, N Jain1, B Changala1, SD Patel1, E Winiger1, A Breier1, A Shekhar1, R Amdur3, D Koller4, JI Nurnberger1, A Corvin5, M Geyer6, MT Tsuang6, D Salomon7, NJ Schork7, AH Fanous3, MC O’Donovan8 and AB Niculescu1,2 We have used a translational convergent functional genomics (CFG) approach to identify and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide association study data with other genetic and gene expression studies in humans and animal models. Using this polyevidence scoring and pathway analyses, we identify top genes (DISC1, TCF4, MBP, MOBP, NCAM1, NRCAM, NDUFV2, RAB18, as well as ADCYAP1, BDNF, CNR1, COMT, DRD2, DTNBP1, GAD1, GRIA1, GRIN2B, HTR2A, NRG1, RELN, SNAP-25, TNIK), brain development, myelination, cell adhesion, glutamate receptor signaling, G-protein-- coupled receptor signaling and cAMP-mediated signaling as key to pathophysiology and as targets for therapeutic intervention. Overall, the data are consistent with a model of disrupted connectivity in schizophrenia, resulting from the effects of neurodevelopmental environmental stress on a background of genetic vulnerability. In addition, we show how the top candidate genes identified by CFG can be used to generate a genetic risk prediction score (GRPS) to aid schizophrenia diagnostics, with predictive ability in independent cohorts. The GRPS also differentiates classic age of onset schizophrenia from early onset and late-onset disease. -
Gene-Based and Pathway-Based Genome-Wide Association Study of Alcohol Dependence
• 111 • Shanghai Archives of Psychiatry, 2015, Vol. 27, No. 2 •Original research article• Gene-based and pathway-based genome-wide association study of alcohol dependence Lingjun ZUO1, Clarence K. ZHANG2,3*, Frederick G. SAYWARD4,5, Kei-Hoi CHEUNG4, Kesheng WANG6, John H. KRYSTAL1, Hongyu ZHAO2, Xingguang LUO1* Background: The organization of risk genes within signaling pathways may provide clues about the converging neurobiological effects of risk genes for alcohol dependence. Aims: Identify risk genes and risk gene pathways for alcohol dependence. Methods: We conducted a pathway-based genome-wide association study (GWAS) of alcohol dependence using a gene-set-rich analytic approach. Approximately one million genetic markers were tested in the discovery sample which included 1409 European-American (EA) alcohol dependent individuals and 1518 EA healthy comparison subjects. An additional 681 African-American (AA) cases and 508 AA healthy subjects served as the replication sample. Results: We identified several genome-wide replicable risk genes and risk pathways that were significantly associated with alcohol dependence. After applying the Bonferroni correction for multiple testing, the ‘cell- extracellular matrix interactions’ pathway (p<2.0E-4 in EAs) and the PXN gene (which encodes paxillin) (p=3.9E-7 in EAs) within this pathway were the most promising risk factors for alcohol dependence. There were also two nominally replicable pathways enriched in alcohol dependence-related genes in both EAs (0.015≤p≤0.035) and AAs (0.025≤p≤0.050): the ‘Na+/Cl- dependent neurotransmitter transporters’ pathway and the ‘other glycan degradation’ pathway. Conclusions: These findings provide new evidence highlighting several genes and biological signaling processes that may be related to the risk for alcohol dependence. -
Combined Web 759..782
Movement Disorders Vol. 24, No. 5, 2009, pp. 759–782 Ó 2009 Movement Disorder Society Brief Reports Clinical Characteristics of Psychogenic movement disorders (PMDs) are not uncommon in movement disorder clinics.1 PMDs may 49 Patients with Psychogenic phenomenologically mimic almost all movement disor- Movement Disorders in a Tertiary ders. The most common movement disorder is tremor, followed by dystonia and others.2–5 Clinic in Turkey Diagnostic criteria for PMDs was first identified by Fahn and Williams, based on atypical and common Sibel Ertan, MD,1 Derya Uluduz, MD,1 clinical clues.6 Later, other authors described additional 1* 1 Sibel O¨ zekmekc¸i, MD, Gu¨nes Kiziltan, MD, features to distinguish PMD patients from those with 2 1 1 Turan Ertan, MD, Cengiz Yalc¸inkaya, MD, , and neurogenic movement disorders.7–9 ¨ 1 and C¸ igdem Ozkara, MD Because there is no study written in English on any 1Department of Neurology, Cerrahpasa Faculty of Medicine, hospital-based data of PMDs in Turkey, we aimed to Istanbul University, Istanbul, Turkey; 2Department of identify the frequency and phenomenological features Psychiatry, Cerrahpasa Faculty of Medicine, Istanbul of PMDs in our patient population with movement dis- University, Istanbul, Turkey orders. Abstract: Patients admitted to movement disorders outpa- tient unit at a university hospital between January 2002 and June 2007 were screened for psychogenic movement PATIENTS AND METHODS disorders (PMDs). Out of 1,743 patients, 49 patients Patients admitted to our Movement Disorders Unit (2.8%), including four children, were diagnosed to have between January 2002 and June 2007, were screened PMDs. Women to men ratio was 34/15. -
Schuljahr 2015/2016 Landkreis Kassel
Ausgewählte Ergebnisse der Schuleingangsuntersuchung 2015 Übergewicht und Fettleibigkeit bis 5% > 5% - 10% > 10% - 15 % > 15% - 20% > 20% - 30% 16% Wahlsburg Bad Karlshafen 11% Oberweser 4% 15% Trendelburg 12% Hofgeismar 18% 14% Reinhardshagen Liebenau 5% Breuna Grebenstein 9% 27% Immenhausen Calden 7% 17% 10% Espenau Fuldatal Zierenberg 13% Vellmar 12% Ahnatal 8% Habichtswald 9% Wolfhagen 10% Niestetal Nieste 10% 9% 15% Zierenberg Kassel Schauenburg Kaufungen 3% Lohfelden 5% 5% Bad Emstal Helsa 8% 2% Baunatal 9% 10% Naumburg Fuldabrück 5% Söhrewald 6% © Stadt Kassel • Vermessung und Geoinformation Meter Quelle: Eigenuntersuchung des Gesundheitsamtes der Region Kassel 0 2.500 5.000 10.000 15.000 Ausgewählte Ergebnisse der Schuleingangsuntersuchung 2015 Vorgelegte Impfbücher bis 84% > 84% - 88% > 88% - 92% > 92% - 96% > 96% - 100% 99% Wahlsburg Bad Karlshafen 84% Oberweser 88% 94% Trendelburg 89% Hofgeismar 96% 95% Reinhardshagen Liebenau Breuna 95% 100% Grebenstein 93% Immenhausen Calden 97% 91% 100% Espenau Fuldatal Zierenberg 96% Vellmar 95% Ahnatal 97% Habichtswald 97% Wolfhagen 90% Niestetal 91% Nieste 95% 100% Kassel Zierenberg Schauenburg Kaufungen 96% Lohfelden 97% 95% Bad Emstal Baunatal Helsa 92% 94% 98% 97% Naumburg Fuldabrück 100% Söhrewald 94% © Stadt Kassel • Vermessung und Geoinformation Meter Quelle: Eigenuntersuchung des Gesundheitsamtes der Region Kassel 0 2.500 5.000 10.000 15.000 Ausgewählte Ergebnisse der Schuleingangsuntersuchung 2015 Impfstatus Hepatitis B bis 80% > 80% - 85% > 85% - 90% > 90% - 95% > 95% - 100% die -
Wegweiser 2020-2
neue der wegweiser NaturFreunde Bezirksverband Kassel e.V. 68. Jahrgang Folge 2/2020 Juni • Juli • August Uns bindet die Liebe - uns bindet die Not Ulrik Erik Overby Inhalt - Editorial Inhalt - Editorial S. 3 NaturFreunde Mitteilungen des Bezirksvorstandes S. 5 Meißnerhaus Unsere Ortsgruppen auf einen Blick: im Naturpark Bad Emstal - Besse S. 6 Meißner-Kaufunger Wald Eschwege - Fürstenhagen S. 7 – 40 km östlich von Kassel – Hessisch Lichtenau - Kassel 2015 S. 8 Kaufungen - Vollmarshausen S. 9 Unsere Vereinsheime auf einen Blick: Vollmarshausen S. 10 Bad Emstal - Kaufungen S. 11 Eschwege S. 12 Liebe Leserinnen, liebe Leser, Wandertermine Ortsgruppe Kassel 2015: als die letzte Ausgabe des Wegweisers Sonntagswandergruppe S. 13 gedruckt war, setzte der Lockdown mittwochs-aktiv I und II S. 14, 15 aufgrund der Coronapandemie ein. Ab Mitte/Ende März kam das Aus den Ortsgruppen: Kassel 2015 komplette Vereinsleben zum Erliegen. - 125 Jahre NaturFreunde - Wichtige Jahrestermine, wie etwa die 125 (?) Wanderungen S. 16, 17 Maikundgebungen oder auch viele Ortsgruppe Vollmarshausen Feierlichkeiten und Aktionen zum - Bildungsausflug Quedlinburg S. 19 125. Jubiläumsjahr konnten nicht Ortsgruppe Hessisch Lichtenau stattfinden. Die Einnahmeausfälle - Verkauf des Naturfreundehauses S. 20, 21 liegen bundesweit im 6-stelligen Bereich, eine Bedrohung der Existenz Beiträge - Veranstaltungen vieler Ortsgruppen und Häuser! Friedensinitiative Gerade jetzt ist es wichtig, dass wir uns - Klimakiller Militär S. 22, 23 Stärkenberater*in - Ausbildung S. 24 gegenseitig unterstützen. Dass dieses Einen Aufenthalt in der Natur des »Königs der Hessischen Berge« und in der gemütlichen Bezirk Nordhessen möglich ist, zeigen erste Versuche z.B. im Bereich der Videokonferenzen, Atmosphäre des Meißnerhauses erleben. - Eröffnung des Natura Trails „Nationalpark Kellerwald-Edersee“ S. -
Experience Grimmheimat Nordhessen
EXPERIENCE GRIMMHEIMAT NORDHESSEN FREE LEISURE FUN WITH INCLUDING ALL LEISURE TIME ACTIVITIES 2020 FREE TRAVEL BY BUS AND TRAIN www.MeineCardPlus.de EXPERIENCE GRIMMHEIMAT NORDHESSEN CONTENT Welcome to Grimms ´home North Hesse About MeineCardPlus 4 North Hesse is the home of the Brothers Grimm. Jacob and Wilhelm Grimm spent most of their lives Map of leisure activities 6 here, in this picture postcard landscape, where they also collected and wrote down their world-famous fairy tales. The Brothers Grimm enjoyed their travels, The for keen swimmers 8 which took them all over the region; numerous diary entries and letters prove how much they loved living here. for underground Follow in their footsteps and discover the Grimms´ The 28 adventures home North Hesse. Your personalised visitor pass MeineCardPlus gives you unrestricted access to this unique region. Experience more than 140 leisure time activities free of charge during your holiday here. The for nature lovers 31 From water park fun to outstanding museums, a chilling ride on a summer toboggan run to a hike in the mountains or remarkable guided city tours. You for leisure time The 37 even travel for free on the region‘s public transport activities system. Refer to this brochure for more detailed information. We hope you have a fun-filled holiday in our fairy tale The for culture 53 region; enjoy your stay and please, tell everyone you know what a magical time you had! Regards, The for mobility 82 your holiday team from the Grimms´ home North Hesse FREE LEISURE FUN WITH MEINE Eintrittskarte ins Urlaubsvergnügen MEIN Fahrschein für Bus & Bahn MEINE Eintrittskarte ins Urlaubsvergnügen MEIN Fahrschein für Bus & Bahn ABOUT MeineCardPlus is your free pass to North Hesse‘s world of Most of the participating leisure, facilities are easily reached leisure time activities. -
Kork-Annahmestellen. Stand: September 2021
Kork-Annahmestellen. Stand: September 2021 Stadt/Gemeinde Ortsteil Straße/Standort Ahnatal Heckershausen An der Ahna 9 (Grundschule) Ahnatal Heckershausen Dorfplatz 2 (Kiga) Ahnatal Heckershausen Dorfplatz 2 (Dienstleistungszentrum) Ahnatal Weimar Königsfahrt 7 (Kiga) Ahnatal Weimar Wilhelmsthaler Str. 3 (Rathaus) Ahnatal Weimar Schulstr. 12 (Helfensteinschule) Bad Emstal Balhorn Bruchstr. 20 a (DGH) Bad Emstal Merxhausen Mittelstr. 13 (Privat) Bad Emstal Riede In der Torwiese (DGH) Bad Emstal Sand Kasseler Str. 57 (Rathaus) Bad Karlshafen Bad Karlshafen C-D.-Stunz-Weg 5 (Grundschule) Bad Karlshafen Bad Karlshafen Carlsstr. 27 (Gesamtschule) Baunatal Altenbauna Marktplatz 14 (Rathaus) Baunatal Großenritte Schulstr. 10 (Kiga) Baunatal Großenritte Hünsteinplatz 2 (Kiga) Baunatal Hertingshausen Werraweg (Bushaltestelle) Breuna Breuna Volkmarser Str. 3 (Rathaus) Espenau Mönchehof Goethestr. 7 (Kiga) Fuldabrück Dennhausen Parkstr. 30 (Pfarrhaus) Fuldabrück Dörnhagen Am Rathaus 2 (Rathaus) Fuldatal Ihringshausen Am Rathaus 9 (Rathaus) Grebenstein Grebenstein Markt 1 (Rathaus) Habichtswald Dönberg Saure Breite 7 (Kiga) Habichtswald Dörnberg Schulstr. 12 (Grundschule) Habichtswald Ehlen Kasseler Str. 8 (Kiga) Habichtswald Ehlen Warmetalstr. 13 (DGH) Helsa Helsa Schulstr. 10 (Grundschule) Helsa Eschenstruth An der langen Wiese 11-13 (Grundschule) Hofgeismar Hofgeismar Kirschenplantage 1 (Entsorgungszentrum Kirschenplantage) Hofgeismar Hofgeismar Brunnenstr. 26 (Gesundbrunnen) Hofgeismar Hofgeismar Garnisionsstr. 6 (Landkreis Kassel) Hofgeismar -
Die Historie Der ADAC Rallye Bad Emstal
Die Historie der ADAC Rallye Bad Emstal Platz 1 - 3 Die erste "Emstal Rallye" wurde als Internationale Rallye am 21. August 1982 durchgeführt. Die Rallye führte über 366 km Gesamtstrecke mit acht Wertungsprüfungen von insgesamt 178 km. Davon wurden 127 km auf Asphalt und 51 km auf Schotter gefahren. 1. Rallye Emstal Uwe Lange, Bad Wildungen Gerhard Schmidt Opel Ascona 21.8.1982 Int. Udo Schwarz, Hirzenhain Wolfgang Drobe, Dautphetal Ford Escord RS 2 Helmut Kreis +, Großenlüder Günter Münster Opel Ascona 2. Rallye Emstal Burkhard Wendel, Kassel Dagmar Lohmann, Kassel Opel Kadett C/GTE 20.8.1983 Int. Eberhard Kromm +, Ranstadt Dieter Hawranke, Kassel Ford Escort Jochen Möller, Schlüchtern Robert Leipold, Schlüchtern Audi 3. Rallye Emstal Udo Schwarz, Hirzenhain Wolfgang Drobe, Dautphetal Ford Escort RS 2000 01.09.1984 Int. Robert Helmert, Wiesbaden Wolfgang Dinges, Wiesbaden Opel Ascona Walter Landsiedel, Weilrod Karl-Heinz Erny, Usingen Opel Ascona 1985 Gründung der Rallye Nordhessen Da es bei den Internationalen Rallyes in Nordhessen zu Überschneidungen bei der Nutzung von Wertungsprüfungen kam, gründeten, auf Drängen von Dr. Oehm, Sportleiter des ADAC Hessen, der MSC Emstal, der KMC Kassel und der MSC Espenau die Veranstaltergemeinschaft "ADAC Rallye Nordhessen". 1986 kam der MSC Reinhardswald dazu. Durch diese Maßnahme entstand aus den drei Nordhessischen Rallyes eine gemeinsame Veranstaltung. 1. Rallye Nordhessen Ralf Richter, Rauenthal Burkhard Wendel, Kassel Opel Ascona 400 24.8.1985 Jörgen Nielsen, Bakke DK Michael Eisenberg, Kopenh. DK Opel Kadett GSI International Rüdiger Hahn, Dachsenhausen Michael Flügel, Neustadt Opel Ascona B 2. Rallye Nordhessen Udo Schwarz, Hirzenhain Wolfgang Drobe, Dautphetal Opel Manta 400 28.6.1986 Rüdiger Kern, Wolfsburg Matthias Feltz, Marburg A-VW Golf GTi International Ludwig Demminger, Wolfsburg Norbert Witkowski, Wesendorf VW Golf 3.