Dermoscopy Patterns of Halo Nevi
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Ukrаiniаn Medicаl Stomаtologicаl Аcаdemy THE DEPАRTАMENT OF PАTHOLOGICАL АNАTOMY WITH SECTIONSL COURSE MАNUАL for the foreign students GENERАL PАTHOMORPHOLOGY Poltаvа-2020 УДК:616-091(075.8) ББК:52.5я73 COMPILERS: PROFESSOR I. STАRCHENKO ASSOCIATIVE PROFESSOR O. PRYLUTSKYI АSSISTАNT A. ZADVORNOVA ASSISTANT D. NIKOLENKO Рекомендовано Вченою радою Української медичної стоматологічної академії як навчальний посібник для іноземних студентів – здобувачів вищої освіти ступеня магістра, які навчаються за спеціальністю 221 «Стоматологія» у закладах вищої освіти МОЗ України (протокол №8 від 11.03.2020р) Reviewers Romanuk A. - MD, Professor, Head of the Department of Pathological Anatomy, Sumy State University. Sitnikova V. - MD, Professor of Department of Normal and Pathological Clinical Anatomy Odessa National Medical University. Yeroshenko G. - MD, Professor, Department of Histology, Cytology and Embryology Ukrainian Medical Dental Academy. A teaching manual in English, developed at the Department of Pathological Anatomy with a section course UMSA by Professor Starchenko II, Associative Professor Prylutsky OK, Assistant Zadvornova AP, Assistant Nikolenko DE. The manual presents the content and basic questions of the topic, practical skills in sufficient volume for each class to be mastered by students, algorithms for describing macro- and micropreparations, situational tasks. The formulation of tests, their number and variable level of difficulty, sufficient volume for each topic allows to recommend them as preparation for students to take the licensed integrated exam "STEP-1". 2 Contents p. 1 Introduction to pathomorphology. Subject matter and tasks of 5 pathomorphology. Main stages of development of pathomorphology. Methods of pathanatomical diagnostics. Methods of pathomorphological research. 2 Morphological changes of cells as response to stressor and toxic damage 8 (parenchimatouse / intracellular dystrophies). -
Classification of Thyroid Tumors Benign Tumors - Adenoma 1
DERMATOPATHOLOGY PATHOLOGY OF ENDOCRINE SYSTEM Thyroid carcinoma, Hashimoto thyroiditis, Graves‘ disease, neuroendocrine tumor, Institute of Pathological Anatomy melanoma, pigmented naevus, psoriasis, eczema FM CU BA DERMATOPATHOLOGY • 10-year-old boy with a pigmented lesion on his shoulder, sharply demarcated from the surrounding skin, with a diameter of 2.3 cm, dark brown in color, without noticeable changes. CASE NO. 1 ➢Suggested examinations? ➢Your diagnosis? ➢Describe the microscopic finding. Pigmented nevus of the skin Congenital pigmented nevus of the skin PIGMENTED NEVUS • benign skin formation arising as a result of melanocyte accumulation • the most common skin lesion of the white race • most nevi form in childhood and adolescence Classification of nevi according to the position of growth in the skin • Junctional nevus - nests of melanocytes are found at the dermo-epidermal junction • Mixed nevus - nests of melanocytes are found at the junction but also in the dermis • Intradermal nevus - clusters of melanocytes are found in the upper part of the dermis WITHOUT connection with the epidermis Histological variants of pigmented nevus • Congenital nevus • Blue nevus • Halo nevus • Familial dysplastic nevus Mixed pigmented nevus Junctional pigmented nevus Intradermal pigmented nevus • 73-year-old patient was admitted to hospital for progressive weakness, shortness of breath. You notice that both the skin and the sclera are icteric. • laboratory hyperbilirubinemia, hypoalbuminemia and mineral imbalance, positive oncomarkers (S100) • abdominal ultrasound with spherical structures found in the liver parenchyma • personal medical history - malignant melanoma of the eye CASE NO. 2 30 years ago, CLL 3 years ago, now in remission ➢Suggested examinations? ➢Your diagnosis? ➢Complications? ➢Describe the microscopic finding. -
Spontaneous Regression of Divided Nevus of the Eyelid Evaluated by Dermoscopy Leaving a Hypopigmented Lesion
Case Report Spontaneous regression of divided nevus of the eyelid evaluated by dermoscopy leaving a hypopigmented lesion Danang Tri Wahyudi1, Izzah Aulia2, Aida S.D. Hoemardani1, Agassi Suseno Sutarjo1 1. Department of Dermatology and Venereology, Dharmais National Cancer Hospital, Jakarta, Indonesia 2. Department of Dermatology and Venereology Faculty of Medicine Universitas Indonesia/ Dr. Cipto Mangunkusumo National Central General Hospital Jakarta, Indonesia Email: [email protected] Abstract Background: Divided nevus, also known as “kissing nevus,” is a rare form of congenital melanocytic nevus that occurs on opposing margins of upper and lower eyelids. A paucity of literature on this rare anomaly exists, with most being case reports and series. Moreover, regression of this lesion was rarely reported. Case Illustration: We present a rare case of congenital divided nevus of the eyelid that regressed after eight years, confirmed with dermoscopy. A siX-year-old boy presented to the Dharmais National Cancer Hospital with two pigmented macules on the upper and lower right eyelid since birth. A year ago, the lesions started gradually disappearing and were replaced by a hypopigmented area. We evaluated the clinical and dermoscopic findings for two consecutive years. The dermoscopy showed pseudopigment networks, surrounded by a hypopigmented area resembling a halo. The pigmented lesions cleared with no residual lesions. Discussion: The dermoscopic findings of the patient resemble a solar lentigo characterized by pseudopigment networks, a feature caused by the relatively flattened rete ridge on the face. The hypopigmented area reflects a regression process, like the halo nevus, and is accompanied by leukotrichia of the eyelashes, a feature usually found in patients with vitiligo. -
Clinical Dermatology Notice
This page intentionally left blank Clinical Dermatology Notice Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The editors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication. However, in view of the possibility of human error or changes in medical sciences, neither the editors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of such information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs. a LANGE medical book Clinical Dermatology Carol Soutor, MD Clinical Professor Department of Dermatology University of Minnesota Medical School Minneapolis, Minnesota Maria K. Hordinsky, MD Chair and Professor Department of Dermatology University of Minnesota Medical School Minneapolis, Minnesota New York Chicago San Francisco Lisbon London Madrid Mexico City Milan New Delhi San Juan Seoul Singapore Sydney Toronto Copyright © 2013 by McGraw-Hill Education, LLC. -
Photo Diagnosis
Photo Diagnosis Illustrated quizzes on problems seen in everyday practice Case 1 An 11-year-old boy presents with pain over the left clavicle after falling from an eight-foot high ladder and landing on a outstretched left hand. Questions 1. What is the diagnosis? 2. What is the significance? Answers 1. Fractured left clavicle. 2. The majority of clavicular fractures heal spontaneously through callus formation. Immobilization of the affected arm for pain control can be easily and effectively accomplished by an arm sling. A figure-of-eight splint offers no advantage over the sling and can be uncomfortable for some children. Inappropriate use of the splint may occasionally even lead to edema of the ipsilateral upper limb, compression of axillary vessels and brachial plexopathy. Provided by Dr. Alexander K.C. Leung; and Dr. Justine H.S. Fong, Calgary, Alberta. Share your photos and diagnoses with us! Do you have a photo diagnosis? Send us your photo and a brief text explaining the presentation of the illness, your diagnosis and treatment, and receive $25 per item if it is published. The Canadian Journal of Diagnosis 955, boul. St. Jean, suite 306, Pointe-Claire (Quebec) H9R 5K3 E-mail: [email protected] Fax: (514) 695-8554 The Canadian Journal of Diagnosis / January 2005 47 Photo Diagnosis Case 2 A 32-year-old former soccer player presents with recurrent attacks of excruciating pain in the right first metatarsophalangeal joint. The attacks have been occurring for the past six months. Questions 1. What is the diagnosis? 2. What is the significance? 3. What is the treatment? Answers 1. -
(12) United States Patent (10) Patent No.: US 7,359,748 B1 Drugge (45) Date of Patent: Apr
USOO7359748B1 (12) United States Patent (10) Patent No.: US 7,359,748 B1 Drugge (45) Date of Patent: Apr. 15, 2008 (54) APPARATUS FOR TOTAL IMMERSION 6,339,216 B1* 1/2002 Wake ..................... 250,214. A PHOTOGRAPHY 6,397,091 B2 * 5/2002 Diab et al. .................. 600,323 6,556,858 B1 * 4/2003 Zeman ............. ... 600,473 (76) Inventor: Rhett Drugge, 50 Glenbrook Rd., Suite 6,597,941 B2. T/2003 Fontenot et al. ............ 600/473 1C, Stamford, NH (US) 06902-2914 7,092,014 B1 8/2006 Li et al. .................. 348.218.1 (*) Notice: Subject to any disclaimer, the term of this k cited. by examiner patent is extended or adjusted under 35 Primary Examiner Daniel Robinson U.S.C. 154(b) by 802 days. (74) Attorney, Agent, or Firm—McCarter & English, LLP (21) Appl. No.: 09/625,712 (57) ABSTRACT (22) Filed: Jul. 26, 2000 Total Immersion Photography (TIP) is disclosed, preferably for the use of screening for various medical and cosmetic (51) Int. Cl. conditions. TIP, in a preferred embodiment, comprises an A6 IB 6/00 (2006.01) enclosed structure that may be sized in accordance with an (52) U.S. Cl. ....................................... 600/476; 600/477 entire person, or individual body parts. Disposed therein are (58) Field of Classification Search ................ 600/476, a plurality of imaging means which may gather a variety of 600/162,407, 477, 478,479, 480; A61 B 6/00 information, e.g., chemical, light, temperature, etc. In a See application file for complete search history. preferred embodiment, a computer and plurality of USB (56) References Cited hubs are used to remotely operate and control digital cam eras. -
Buffalo Medical Group, P.C. Robert E
Buffalo Medical Group, P.C. Robert E. Kalb, M.D. Phone: (716) 630-1102 Fax: (716) 633-6507 Department of Dermatology 325 Essjay Road Williamsville, New York 14221 2 FOOT- 1 HAND SYNDROME 2 foot - 1 hand syndrome is a superficial infection of the skin caused by the common athlete's foot fungus. It is quite common for people to have a minor amount of an athlete's foot condition. This would appear as slight scaling and/or itching between the toes. In addition, patients may have thickened toenails as part of the athlete's foot condition. Again the problem on the feet is very common and often patients are not even aware of it. In some patients, however, the athlete's foot fungus can spread to another area of the body. For some strange and unknown reason, it seems to affect only one hand. That is why the condition is called 2 foot - 1 hand syndrome. It is not clear why the problem develops in only one hand or why the right or left is involved in some patients. Fortunately there is very effective treatment to control this minor skin problem. If the problem with the superficial fungus infection is confined to the skin, then a short course of treatment with an oral antibiotic is all that is required. This antibiotic is very safe and normally clears the skin up fairly rapidly. It is often used with a topical cream to speed the healing process. If, however, the fingernails of the affected hand are also involved then a more prolonged course of the antibiotic will be necessary. -
2014 Slide Library Case Summary Questions & Answers With
2014 Slide Library Case Summary Questions & Answers with Discussions 51st Annual Meeting November 6-9, 2014 Chicago Hilton & Towers Chicago, Illinois The American Society of Dermatopathology ARTHUR K. BALIN, MD, PhD, FASDP FCAP, FASCP, FACP, FAAD, FACMMSCO, FASDS, FAACS, FASLMS, FRSM, AGSF, FGSA, FACN, FAAA, FNACB, FFRBM, FMMS, FPCP ASDP REFERENCE SLIDE LIBRARY November 2014 Dear Fellows of the American Society of Dermatopathology, The American Society of Dermatopathology would like to invite you to submit slides to the Reference Slide Library. At this time there are over 9300 slides in the library. The collection grew 2% over the past year. This collection continues to grow from member’s generous contributions over the years. The slides are appreciated and are here for you to view at the Sally Balin Medical Center. Below are the directions for submission. Submission requirements for the American Society of Dermatopathology Reference Slide Library: 1. One H & E slide for each case (if available) 2. Site of biopsy 3. Pathologic diagnosis Not required, but additional information to include: 1. Microscopic description of the slide illustrating the salient diagnostic points 2. Clinical history and pertinent laboratory data, if known 3. Specific stain, if helpful 4. Clinical photograph 5. Additional note, reference or comment of teaching value Teaching sets or collections of conditions are especially useful. In addition, infrequently seen conditions are continually desired. Even a single case is helpful. Usually, the written submission requirement can be fulfilled by enclosing a copy of the pathology report prepared for diagnosis of the submitted case. As a guideline, please contribute conditions seen with a frequency of less than 1 in 100 specimens. -
Osteopathic Journal Feb 2006 6
Journal of the AMERICAN OSTEOPATHIC COLLEGE OF DERMATOLOGY 2005-2006 Officers Journal of the President: Richard A. Miller, DO President-Elect: Bill V. Way, DO American First Vice-President: Jay S. Gottlieb, DO Second Vice-President: Donald K. Tillman, DO Third Vice-President: Marc I. Epstein, DO Osteopathic Secretary-Treasurer: Jere J. Mammino, DO Immediate Past President: Ronald C. Miller, DO College Trustees: David W. Dorton, DO Bradley P. Glick, DO of Dermatology Daniel S. Hurd, DO Jeffrey N. Martin, DO Executive Director: Rebecca Mansfield, MA Editors Jay S. Gottlieb, D.O., F.O.C.O.O. Stanley E. Skopit, D.O., F.A.O.C.D. Associate Editor James Q. Del Rosso, D.O., F.A.O.C.D. Editorial Review Board Ronald Miller, D.O. Eugene Conte, D.O. Evangelos Poulos, M.D. Stephen Purcell, D.O. AOCD • 1501 E. Illinois • Kirksville, MO 63501 Darrel Rigel, M.D. 800-449-2623 • FAX: 660-627-2623 www.aocd.org Robert Schwarze, D.O. Andrew Hanly, M.D. COPYRIGHT AND PERMISSION: written permission must be Michael Scott, D.O. obtained from the Journal of the American Osteopathic College of Dermatology for copying or reprinting text of more than half page, Cindy Hoffman, D.O. tables or figures. Permissions are normally granted contingent upon Charles Hughes, D.O. similar permission from the author(s), inclusion of acknowledgement Bill Way, D.O. of the original source, and a payment of $15 per page, table or figure of reproduced material. Permission fees are waived for authors Daniel Hurd, D.O. wishing to reproduce their own articles. -
Pediatric Dermatology- Pigmented Lesions
Pediatric Dermatology- Pigmented Lesions OPTI-West/Western University of Health Sciences- Silver Falls Dermatology Presenters: Bryce Lynn Desmond, DO; Ben Perry, DO Contributions from: Lauren Boudreaux, DO; Stephanie Howerter, DO; Collin Blattner, DO; Karsten Johnson, DO Disclosures • We have no financial or conflicts of interest to report Melanocyte Basic Science • Neural crest origin • Migrate to epidermis, dermis, leptomeninges, retina, choroid, iris, mucous membrane epithelium, inner ear, cochlea, vestibular system • Embryology • First appearance at the end of the 1st trimester • Able to synthesize melanin at the beginning of the 2nd trimester • Ratio of melanocytes to basal cells is 1:10 in skin and 1:4 in hair • Equal numbers of melanocytes across different races • Type, number, size, dispersion, and degree of melanization of the melanosomes determines pigmentation Nevus of Ota • A.k.a. Nevus Fuscocoeruleus Ophthalmomaxillaris • Onset at birth (50-60%) or 2nd decade • Larger than mongolian spot, does not typically regress spontaneously • Often first 2 branches of trigeminal nerve • Other involved sites include ipsilateral sclera (~66%), tympanum (55%), nasal mucosa (30%). • ~50 cases of melanoma reported • Reported rates of malignant transformation, 0.5%-25% in Asian populations • Ocular melanoma of choroid, orbit, chiasma, meninges have been observed in patients with clinical ocular hyperpigmentation. • Acquired variation seen in primarily Chinese or Japanese adults is called Hori’s nevus • Tx: Q-switched ruby, alexandrite, and -
Eczema & Psoriasis
ECZEMA AND PSORIASIS DR SUNITA GOSSAIN CONSULTANT DERMATOLOGIST FRIMLEY PARK HOSPITAL, NHS FOUNDATION TRUST NORTH DOWNS HOSPITAL CATERHAM PARKSIDE SUITES, FRIMLEY PARK HOSPITAL ST ANTONY’S HOSPITAL CHEAM INTRODUCTION • Incidence and prevalence – 20% & 2% • Days lost of school and work • Skin disease is distressing and disabling • Patient expectations • Eczema & Psoriasis on a spectrum • Acute, subacute & chronic • Classify/make the diagnosis/descriptive ATOPIC DERMATITIS * atopic tendency * family history * skin barrier function- filaggrin * complex interaction of genetic and environmental ATOPIC DERMATITIS • Infants –widespread • Toddlers- localised, extensors • Children –flexural, eyelids, neck • Adults –hands, diffuse pattern IRRITANT CONTACT DERMATITIS • environmental factors such as cold, over- exposure to water, chemicals such as acids, alkalis, detergents, solvents. • Irritants remove oils • water, detergents, solvents, acids, alkalis, adhesives, metalworking fluids and friction • Type –dribble, napkin, friction/skin folds, hand, housewife’s ALLERGIC CONTACT DERMATITIS • Allergen, Type 4 hypersensitivity, CD4 T-cell, cytokines, tiny exposure • External not internal or air-bourne allergens • Impaired barrier function, leg ulcers • Localised+/- generalised (autosensitisation) • metal workers, hairdressers, beauticians, health care workers, cleaners, painters and florists • Topical antibiotics • Nail cosmetics, acrylates • Nickel, plasters, fragrances, rubber accelerators/gloves, dental implants, black hair Dye/PPD/IPPD Methylisothiazolinone -
Key Words, General Index
Key words, general index (1/1991-4/2018) The number on the left indicates the initial page of the original article, whereas the number on the right of the bar-line indicates the year of publication of European Journal of Pediatric Dermatology. The numbers followed by “t” refer to the page of the Practical Pediatric Dermatology; the numbers followed by “d” refer to the page of the Pediatric Dermoscopy Book. They are followed, after the bar-line, by the year of publication. Absorption, percutaneous ALDY 182/16 tongue 233/05 newborn 157/91 (vs) superficial morphea 132/16 Angioma, eruptive Acanthosis nigricans 85/03 Allergic contact dermatitis satellitosis 207/10 Crouzon, syndrome 209/96 airborne 29/18 topical timolol 213/16 Acetominophen minoxidil 122/17 Angioma, flat, midline 81/03 fixed drug eruption 123/17 henné 93/03, 55/11 and lateral 149/99 Acitretin 151/09 propranolol 122/14 Angioma, lobular, pruritus 63/18 (and) psoriasis 120/09 eruptive 481t/00 Acne 337t/98 topical corticosteroids 29/01 palmar 91/06 (vs) angiofibromas 135/99 Allergy, rubber 215/01 Angioma, microvenular 33/97 port-wine 256/11 Allergy, food Angioma, port-wine 156/10 questionnaire 32/18 alternative medicine 165/03 Angioma, tufted 210/03, violinist 120/11 Alopecia, androgenetic 56/16 154/09, 233/12 Acne Alopecia, break dance 92/06, 254/15 Anhidrosis cystic rosacea-like 7/13 Alopecia areata 63/09 peripheral neuropathy 237/12 (and) vascular lesions 186/18 dermoscopy 132/09, 133/09 Anisakis Acne, neonatal Down 7/14 atopic dermatitis 109/08 (vs) atopic dermatitis 10/92 incognita 187/14 Anitis, streptococcal 19/09 retinoids 81/98 neonatal 56/11, 252/14 Anonychia, congenital 253/08 Acne, steroid 282/12 tacrolimus 227/07 Anticonvulsant drugs Acne, vulgaris 185/10 Alopecia, androgenetic hyperpigmentation 64/18 Acremoniasis 71/11 tricho-rhino-phalangeal s.