Eczema & Psoriasis
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General Pathomorpholog.Pdf
Ukrаiniаn Medicаl Stomаtologicаl Аcаdemy THE DEPАRTАMENT OF PАTHOLOGICАL АNАTOMY WITH SECTIONSL COURSE MАNUАL for the foreign students GENERАL PАTHOMORPHOLOGY Poltаvа-2020 УДК:616-091(075.8) ББК:52.5я73 COMPILERS: PROFESSOR I. STАRCHENKO ASSOCIATIVE PROFESSOR O. PRYLUTSKYI АSSISTАNT A. ZADVORNOVA ASSISTANT D. NIKOLENKO Рекомендовано Вченою радою Української медичної стоматологічної академії як навчальний посібник для іноземних студентів – здобувачів вищої освіти ступеня магістра, які навчаються за спеціальністю 221 «Стоматологія» у закладах вищої освіти МОЗ України (протокол №8 від 11.03.2020р) Reviewers Romanuk A. - MD, Professor, Head of the Department of Pathological Anatomy, Sumy State University. Sitnikova V. - MD, Professor of Department of Normal and Pathological Clinical Anatomy Odessa National Medical University. Yeroshenko G. - MD, Professor, Department of Histology, Cytology and Embryology Ukrainian Medical Dental Academy. A teaching manual in English, developed at the Department of Pathological Anatomy with a section course UMSA by Professor Starchenko II, Associative Professor Prylutsky OK, Assistant Zadvornova AP, Assistant Nikolenko DE. The manual presents the content and basic questions of the topic, practical skills in sufficient volume for each class to be mastered by students, algorithms for describing macro- and micropreparations, situational tasks. The formulation of tests, their number and variable level of difficulty, sufficient volume for each topic allows to recommend them as preparation for students to take the licensed integrated exam "STEP-1". 2 Contents p. 1 Introduction to pathomorphology. Subject matter and tasks of 5 pathomorphology. Main stages of development of pathomorphology. Methods of pathanatomical diagnostics. Methods of pathomorphological research. 2 Morphological changes of cells as response to stressor and toxic damage 8 (parenchimatouse / intracellular dystrophies). -
Gianotti-Crosti Syndrome
GIANOTTI-CROSTI SYNDROME http://www.aocd.org Gianotti-Crosti Syndrome (GCS) is also known as ‘papular acrodermatitis of childhood’ and ‘papulovesicular acrolated syndrome’. GCS is a viral eruption that typically begins on the buttocks and spreads to other areas of the body. The rash also affects the face and the extremities. The chest, back, belly, palms and soles are usually spared. In the United States, it is most commonly caused by Epstein-Barr virus infection. Hepatitis B is a common cause in parts of the world where the vaccination is not given. Other viruses that cause the rash include hepatitis A and C, cytomegalovirus, enterovirus, coxsackievirus, rotavirus, adenovirus, human herpes virus-6, respiratory syncytial virus, parvovirus B10, rubella, HIV, and parainfluenza. It has also been associated with viral immunizations for poliovirus, hepatitis A, diphtheria, small pox, pertussis and influenza. GCS most commonly occurs in children between the ages of one to three but can occur at any time from the ages of three months to fifteen years. The condition manifests more commonly in the spring and summer and lasts for four weeks but can last up to eight weeks. The rash has been known to occur more commonly in children with atopic dermatitis. The lesions present as single, red to pink to brown colored bumps that may be fluid-filled. The size of the lesions can range from one to ten millimeters and present symmetrically. The bumps can come together and form larger lesions. Sometimes the child may present with a fever, enlarged tender lymph nodes and an enlarged spleen or liver. -
Urticaria from Wikipedia, the Free Encyclopedia Jump To: Navigation, Search "Hives" Redirects Here
Urticaria From Wikipedia, the free encyclopedia Jump to: navigation, search "Hives" redirects here. For other uses, see Hive. Urticaria Classification and external resourcesICD-10L50.ICD- 9708DiseasesDB13606MedlinePlus000845eMedicineemerg/628 MeSHD014581Urtic aria (or hives) is a skin condition, commonly caused by an allergic reaction, that is characterized by raised red skin wheals (welts). It is also known as nettle rash or uredo. Wheals from urticaria can appear anywhere on the body, including the face, lips, tongue, throat, and ears. The wheals may vary in size from about 5 mm (0.2 inches) in diameter to the size of a dinner plate; they typically itch severely, sting, or burn, and often have a pale border. Urticaria is generally caused by direct contact with an allergenic substance, or an immune response to food or some other allergen, but can also appear for other reasons, notably emotional stress. The rash can be triggered by quite innocent events, such as mere rubbing or exposure to cold. Contents [hide] * 1 Pathophysiology * 2 Differential diagnosis * 3 Types * 4 Related conditions * 5 Treatment and management o 5.1 Histamine antagonists o 5.2 Other o 5.3 Dietary * 6 See also * 7 References * 8 External links [edit] Pathophysiology Allergic urticaria on the shin induced by an antibiotic The skin lesions of urticarial disease are caused by an inflammatory reaction in the skin, causing leakage of capillaries in the dermis, and resulting in an edema which persists until the interstitial fluid is absorbed into the surrounding cells. Urticarial disease is thought to be caused by the release of histamine and other mediators of inflammation (cytokines) from cells in the skin. -
Dyshidrotic Eczema
University of Calgary PRISM: University of Calgary's Digital Repository Cumming School of Medicine Cumming School of Medicine Research & Publications 2014-09-16 Dyshidrotic eczema Leung, Alexander K.C.; Barankin, Benjamin; Hon, Kam Lun Enliven Archive Leung AK, Barankin B, Hon KL (2014) Dyshidrotic Eczema. Enliven: Pediatr Neonatol Biol 1(1): 002. http://hdl.handle.net/1880/50267 journal article Downloaded from PRISM: https://prism.ucalgary.ca Research Article www.enlivenarchive.org Enliven: Pediatrics and Neonatal Biology Dyshidrotic Eczema Alexander K. C. Leung1*, Benjamin Barankin2, and Kam Lun Hon3 1Clinical Professor of Pediatrics, University of Calgary, Pediatric Consultant, Alberta Children’s Hospital 2Medical Director and Founder, Toronto Dermatology Centre 3Professor of Pediatrics, Chinese University of Hong Kong * Corresponding author: Alexander K. C. Leung, MBBS, FRCPC, FRCP Citation: Leung AK, Barankin B, Hon KL (2014) Dyshidrotic Eczema. (UK & Irel), FRCPCH, FAAP, Clinical Professor of Pediatrics, University Enliven: Pediatr Neonatol Biol 1(1): 002. of Calgary, Pediatric Consultant, Alberta Children’s Hospital, Canada, Tel: Copyright:@ 2014 Dr. Alexander K. C. Leung. This is an Open Access (403) 230-3322; Fax: (403) 230-3322; E-mail: [email protected] article published and distributed under the terms of the Creative Commons th Received Date: 14 August 2014 Attribution License, which permits unrestricted use, distribution and th Accepted Date: 10 September 2014 reproduction in any medium, provided the original author and source are th Published Date: 16 September 2014 credited. Abstract Dyshidrotic eczema, also known as dyshidrotic dermatitis or pompholyx, is characterized by pruritic, tense, deep-seated vesicles mainly on the palms and lateral surfaces of the fingers. -
Classification of Thyroid Tumors Benign Tumors - Adenoma 1
DERMATOPATHOLOGY PATHOLOGY OF ENDOCRINE SYSTEM Thyroid carcinoma, Hashimoto thyroiditis, Graves‘ disease, neuroendocrine tumor, Institute of Pathological Anatomy melanoma, pigmented naevus, psoriasis, eczema FM CU BA DERMATOPATHOLOGY • 10-year-old boy with a pigmented lesion on his shoulder, sharply demarcated from the surrounding skin, with a diameter of 2.3 cm, dark brown in color, without noticeable changes. CASE NO. 1 ➢Suggested examinations? ➢Your diagnosis? ➢Describe the microscopic finding. Pigmented nevus of the skin Congenital pigmented nevus of the skin PIGMENTED NEVUS • benign skin formation arising as a result of melanocyte accumulation • the most common skin lesion of the white race • most nevi form in childhood and adolescence Classification of nevi according to the position of growth in the skin • Junctional nevus - nests of melanocytes are found at the dermo-epidermal junction • Mixed nevus - nests of melanocytes are found at the junction but also in the dermis • Intradermal nevus - clusters of melanocytes are found in the upper part of the dermis WITHOUT connection with the epidermis Histological variants of pigmented nevus • Congenital nevus • Blue nevus • Halo nevus • Familial dysplastic nevus Mixed pigmented nevus Junctional pigmented nevus Intradermal pigmented nevus • 73-year-old patient was admitted to hospital for progressive weakness, shortness of breath. You notice that both the skin and the sclera are icteric. • laboratory hyperbilirubinemia, hypoalbuminemia and mineral imbalance, positive oncomarkers (S100) • abdominal ultrasound with spherical structures found in the liver parenchyma • personal medical history - malignant melanoma of the eye CASE NO. 2 30 years ago, CLL 3 years ago, now in remission ➢Suggested examinations? ➢Your diagnosis? ➢Complications? ➢Describe the microscopic finding. -
Spontaneous Regression of Divided Nevus of the Eyelid Evaluated by Dermoscopy Leaving a Hypopigmented Lesion
Case Report Spontaneous regression of divided nevus of the eyelid evaluated by dermoscopy leaving a hypopigmented lesion Danang Tri Wahyudi1, Izzah Aulia2, Aida S.D. Hoemardani1, Agassi Suseno Sutarjo1 1. Department of Dermatology and Venereology, Dharmais National Cancer Hospital, Jakarta, Indonesia 2. Department of Dermatology and Venereology Faculty of Medicine Universitas Indonesia/ Dr. Cipto Mangunkusumo National Central General Hospital Jakarta, Indonesia Email: [email protected] Abstract Background: Divided nevus, also known as “kissing nevus,” is a rare form of congenital melanocytic nevus that occurs on opposing margins of upper and lower eyelids. A paucity of literature on this rare anomaly exists, with most being case reports and series. Moreover, regression of this lesion was rarely reported. Case Illustration: We present a rare case of congenital divided nevus of the eyelid that regressed after eight years, confirmed with dermoscopy. A siX-year-old boy presented to the Dharmais National Cancer Hospital with two pigmented macules on the upper and lower right eyelid since birth. A year ago, the lesions started gradually disappearing and were replaced by a hypopigmented area. We evaluated the clinical and dermoscopic findings for two consecutive years. The dermoscopy showed pseudopigment networks, surrounded by a hypopigmented area resembling a halo. The pigmented lesions cleared with no residual lesions. Discussion: The dermoscopic findings of the patient resemble a solar lentigo characterized by pseudopigment networks, a feature caused by the relatively flattened rete ridge on the face. The hypopigmented area reflects a regression process, like the halo nevus, and is accompanied by leukotrichia of the eyelashes, a feature usually found in patients with vitiligo. -
Clinical Dermatology Notice
This page intentionally left blank Clinical Dermatology Notice Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The editors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication. However, in view of the possibility of human error or changes in medical sciences, neither the editors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of such information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs. a LANGE medical book Clinical Dermatology Carol Soutor, MD Clinical Professor Department of Dermatology University of Minnesota Medical School Minneapolis, Minnesota Maria K. Hordinsky, MD Chair and Professor Department of Dermatology University of Minnesota Medical School Minneapolis, Minnesota New York Chicago San Francisco Lisbon London Madrid Mexico City Milan New Delhi San Juan Seoul Singapore Sydney Toronto Copyright © 2013 by McGraw-Hill Education, LLC. -
Guías Diagnósticas Y Terapeúticas De Las 10 Patologías Más Frecuentes
HOSPITAL INFANTIL DE MÉXICO “FEDERICO GÓMEZ” SERVICIO DE DERMATOLOGÍA GUÍAS DIAGNÓSTICAS Y TERAPÉUTICAS DE LAS 10 PATOLOGÍAS MÁS FRECUENTES DR CARLOS ALFREDO MENA CEDILLOS, JEFE DEL SERVICIO DRA ADRIANA MARÍA VALENCIA HERRERA DERMATITIS ATOPICA SINONIMIA. Neurodermatitis, prurigo de Besnier, eccema del lactante. DEFINICION. Enfermedad reaccional, crónica y recidivante de la piel, con un patrón clínico e historia natural característicos. No se conoce la causa específica, pero se ha relacionado con susceptibilidad genética, disturbios inmuológicos y constitucionales, sobre los que actúan factores desencadenantes. EPIDEMIOLOGIA: Es la dermatosis más frecuente en población pediátrica. La prevalencia ha mostrando incremento en las últimas décadas, siendo del 18-20%. Es mas frecuente en áreas urbanas de países industrializados, especialmente en inmigrantes provenientes de países con menor prevalencia. No existe clara predilección racial ni diferencia en cuanto al sexo. Puede presentarse a cualquier edad, con claro predominio en la población pediátrica, 60-85% de los casos inicia en el primer año de vida y 85-95% antes de los 5 años; 10-25% de los casos persiste con recaídas en la edad adulta. ETIOPATOGENIA. La etiología es desconocida pero parece ser resultado de una compleja interacción aspectos genéticos, inmunológicos y defectos en la barrera epidérmica, existiendo múltiples factores descencadenantes, queactúan sobre un terreno constitucionalmente alterado. 1. Anomalías genéticas. Tiene clara naturaleza familiar, pero no se ha precisado el mecanismo de herencia, existiendo en 70% de los pacientes antecedentes de atopia. Los antígenos de histocompatibilidad HL-A9, HL-A3, HL-B12 y HL-Bw40 se han descrito en estos pacientes. 2. Disturbios inmunológicos. Existen cambios significativos en la inmunidad humoral y celular. -
My Approach to Superficial Inflammatory Dermatoses K O Alsaad, D Ghazarian
1233 J Clin Pathol: first published as 10.1136/jcp.2005.027151 on 25 November 2005. Downloaded from REVIEW My approach to superficial inflammatory dermatoses K O Alsaad, D Ghazarian ............................................................................................................................... J Clin Pathol 2005;58:1233–1241. doi: 10.1136/jcp.2005.027151 Superficial inflammatory dermatoses are very common and diagnosis of inflammatory skin diseases, there are limitations to this approach. The size of the comprise a wide, complex variety of clinical conditions. skin biopsy should be adequate and representa- Accurate histological diagnosis, although it can sometimes tive of all four compartments and should also be difficult to establish, is essential for clinical include hair follicles. A 2 mm punch biopsy is too small to represent all compartments, and often management. Knowledge of the microanatomy of the skin insufficient to demonstrate a recognisable pat- is important to recognise the variable histological patterns tern. A 4 mm punch biopsy is preferred, and of inflammatory skin diseases. This article reviews the non- usually adequate for the histological evaluation of most inflammatory dermatoses. However, a vesiculobullous/pustular inflammatory superficial larger biopsy (6 mm punch biopsy), or even an dermatoses based on the compartmental microanatomy of incisional biopsy, might be necessary in panni- the skin. culitis or cutaneous lymphoproliferative disor- ders. A superficial or shave biopsy should be .......................................................................... -
Photo Diagnosis
Photo Diagnosis Illustrated quizzes on problems seen in everyday practice Case 1 An 11-year-old boy presents with pain over the left clavicle after falling from an eight-foot high ladder and landing on a outstretched left hand. Questions 1. What is the diagnosis? 2. What is the significance? Answers 1. Fractured left clavicle. 2. The majority of clavicular fractures heal spontaneously through callus formation. Immobilization of the affected arm for pain control can be easily and effectively accomplished by an arm sling. A figure-of-eight splint offers no advantage over the sling and can be uncomfortable for some children. Inappropriate use of the splint may occasionally even lead to edema of the ipsilateral upper limb, compression of axillary vessels and brachial plexopathy. Provided by Dr. Alexander K.C. Leung; and Dr. Justine H.S. Fong, Calgary, Alberta. Share your photos and diagnoses with us! Do you have a photo diagnosis? Send us your photo and a brief text explaining the presentation of the illness, your diagnosis and treatment, and receive $25 per item if it is published. The Canadian Journal of Diagnosis 955, boul. St. Jean, suite 306, Pointe-Claire (Quebec) H9R 5K3 E-mail: [email protected] Fax: (514) 695-8554 The Canadian Journal of Diagnosis / January 2005 47 Photo Diagnosis Case 2 A 32-year-old former soccer player presents with recurrent attacks of excruciating pain in the right first metatarsophalangeal joint. The attacks have been occurring for the past six months. Questions 1. What is the diagnosis? 2. What is the significance? 3. What is the treatment? Answers 1. -
Dermatological Indications of Disease - Part II This Patient on Dialysis Is Showing: A
“Cutaneous Manifestations of Disease” ACOI - Las Vegas FR Darrow, DO, MACOI Burrell College of Osteopathic Medicine This 56 year old man has a history of headaches, jaw claudication and recent onset of blindness in his left eye. Sed rate is 110. He has: A. Ergot poisoning. B. Cholesterol emboli. C. Temporal arteritis. D. Scleroderma. E. Mucormycosis. Varicella associated. GCA complex = Cranial arteritis; Aortic arch syndrome; Fever/wasting syndrome (FUO); Polymyalgia rheumatica. This patient missed his vaccine due at age: A. 45 B. 50 C. 55 D. 60 E. 65 He must see a (an): A. neurologist. B. opthalmologist. C. cardiologist. D. gastroenterologist. E. surgeon. Medscape This 60 y/o male patient would most likely have which of the following as a pathogen? A. Pseudomonas B. Group B streptococcus* C. Listeria D. Pneumococcus E. Staphylococcus epidermidis This skin condition, erysipelas, may rarely lead to septicemia, thrombophlebitis, septic arthritis, osteomyelitis, and endocarditis. Involves the lymphatics with scarring and chronic lymphedema. *more likely pyogenes/beta hemolytic Streptococcus This patient is susceptible to: A. psoriasis. B. rheumatic fever. C. vasculitis. D. Celiac disease E. membranoproliferative glomerulonephritis. Also susceptible to PSGN and scarlet fever and reactive arthritis. Culture if MRSA suspected. This patient has antithyroid antibodies. This is: • A. alopecia areata. • B. psoriasis. • C. tinea. • D. lichen planus. • E. syphilis. Search for Hashimoto’s or Addison’s or other B8, Q2, Q3, DRB1, DR3, DR4, DR8 diseases. This patient who works in the electronics industry presents with paresthesias, abdominal pain, fingernail changes, and the below findings. He may well have poisoning from : A. lead. B. -
Potential Approaches Towards Dermatitis
l of Derm na a r t u it i o s J ISSN: 2684-1436 Journal of Dermatitis Editorial Note Potential Approaches towards Dermatitis Nabanita Mukherjee* Department of Dermatology, University of Colorado, Anschutz Medical Campus, USA EDITORIAL NOTE An article titled “The Impact of Microanatomy and Changing Dermatitis, well known as eczema, is defined as a group of Physiology of Stratum Corneum, the Skin Barrier, on Evolution diseases causing skin inflammation. They are caused due to of Atopic Dermatitis”, written by Dr.Virendra N Sehgal which adverse drug reactions. It is generally characterized by rashes, discusses the effect of changing of pattern and characteristics of redness of skin, itchiness or growth of small blisters. Long term stratum corneum taking salient featuring stock of microanatomy causation of this disease may cause thickening of the skin and and physiology[1]. The article is about degradation of certain can vary to spread from small area of skin to the entire body. It proteins due to the up-regulation of serine protease activity, includes mainly allergic contact dermatitis, atopic dermatitis, filaggrin being the predisposing factor in the pathogenesis of irritant contact dermatitis and stasis dermatitis. It belongs to the AD, its treatments and preventive measures. branch of Dermatological immunology. It is not a life Other article titled “A Randomized Trial to Evaluate the Efficacy threatening and contagious disease. and Saftey of 1% Pimecrolimus Cream vs. 0.05% Clobetasol The Journal of Dermatitis is a peer-reviewed, open access Propionate Cream for the Treatment of Childhood Vitiligo”[2], scientific journal dealing with articles on various arenas of written by Dr, Preeti Sharma, et all.