Table 3. Signature genes. Normalized Average Expression Level kmean Function Clone Name Putative Identification FI ES TS3 TS6 Cluster #4 Apoptosis H3035A01 Mouse tumor necrosis factor, alpha-induced protein 2 (Tnfaip2)/ B94 -0.487 0.781 -0.269 -0.28 H3100E04 Mouse inhibitor of apoptosis protein 1 -0.404 0.56 -0.713 -0.117

Cell Cycle H3019C10 Mouse prohibitin (Phb), antiproliferative protein -0.702 0.67 -0.177 -0.162 H3025D07 Mouse Ki-67 -0.115 0.539 -0.592 -0.586 H3116H01 Mouse CDC10 -0.21 0.53 -0.619 -0.539

Transcription/Chromatin H3016B10 Human leucine zipper, down-regulated in cancer 1 (LDOC1) -0.627 0.6 -0.485 0.1 H3036F04 Mouse REX-1 -0.647 0.558 -0.445 -0.264 H3086G02 Mouse DNA methyltransferase 3A (Dnmt3a) -0.669 0.576 -0.328 -0.333 H3105D05 Mouse zinc finger protein 57 (Zfp57) -0.82 0.51 -0.216 -0.138 H3128E07 Mouse cysteine-rich protein 2 CRP2/SmLIM -0.344 0.662 -0.656 -0.111

DNA Replication H3039G12 Mouse 5'-3' exoribonuclease 1 (Xrn1)/Dhm2 -0.192 0.632 -0.575 -0.48 H3064A08 Human replication factor C3 -0.495 0.703 -0.507 -0.04

Energy/Metabolism H3021A12 Mouse tryptophan-tRNA ligase -0.607 0.56 -0.56 -0.058 H3040F06 Mouse Mpv17 transgene, kidney disease mutant (Mpv17), peroxisomal protein -0.453 0.542 -0.699 -0.106 H3043F12 Mouse ferrochelatase (Fech)/ protoheme ferrolyase -0.466 0.514 -0.662 -0.279 H3047F02 Mouse vacuolar-adenosine trisphosphatase -0.596 0.308 -0.734 -0.092 H3075A04 Putative sheep protein-arginine deiminase typeIII -0.022 0.422 -0.906 -0.013 H3090E05 Mouse P450 (cytochrome) oxidoreductase (Por) -0.332 0.564 -0.534 -0.533 H3119G08 Mouse glutathione S-transferase alpha 4 (Gsta4) -0.544 0.477 -0.673 0.146

Heat Shock/Stress H3013D11 Mouse metallothionein II -0.286 0.528 -0.796 0.068 Heat Shock/Stress H3023G01 Mouse heat shock protein 86 kDa 1 (Hsp86-1) -0.659 0.632 -0.076 -0.398

Matrix/Structural Proteins H3015H02 Mouse serine protease inhibitor 6 (Spi6) -0.514 0.66 -0.545 -0.036 H3035B02 Mouse skeletal muscle alpha tropomyosin -0.297 0.676 -0.672 -0.033 H3093F11 Human secretory carrier membrane protein 1 (SCAMP1) -0.414 0.138 -0.884 -0.165 H3097E02 Mouse EH-domain containing protein 2 (Ehd2) -0.355 0.34 -0.869 0.04 H3100F04 Putative human beta-tryptase precursor -0.706 0.527 -0.43 -0.193 H3101B07 Mouse brain neurofilament-L -0.618 0.135 -0.646 -0.426 H3104H03 Putative mouse kinesin-like protein KIF1A -0.763 0.508 -0.37 -0.147 H3116G01 Mouse nuclear pore complex glycoprotein p62 -0.304 0.6 -0.535 -0.509 H3135C02 Mouse galectin-7 keratinocyte lectin -0.34 0.788 -0.411 -0.305

Protein Synthesis/Translational Control H3037E02 Human putative pre-mRNA splicing factor, ATP-dependent RNA helicase -0.329 0.653 -0.402 -0.55 H3073A06 Mouse beta-transducin repeat containing protein/F-box/WD40-repeat protein FWD1 -0.437 0.311 -0.841 0.053 H3135B05 Mouse beta-transducin repeat containing protein/F-box/WD40-repeat protein FWD1 -0.02 0.637 -0.676 -0.367

Signal Transduction H3005F06 Mouse interleukin 1 receptor-associated kinase (Il1rak) -0.187 0.536 -0.803 -0.177 H3035B01 Human putative phosphoprotein C8FW -0.3 0.772 -0.278 -0.484 H3062G12 Mouse large tumor suppressor 1 (Lats1) putative protein kinase -0.407 0.38 -0.817 0.145 H3064C02 Mouse large tumor suppressor 1 (Lats1) putative protein kinase -0.383 0.618 -0.634 -0.26 H3088G02 Human GTP-binding protein (NGB) -0.615 0.527 -0.571 -0.131 H3126B12 Mouse protein kinase inhibitor, gamma (Pkig) -0.674 0.588 -0.437 -0.085 H3136E09 Mouse Rho-associated coiled-coil forming kinase 1 (Rock1) -0.185 0.751 -0.439 -0.455

Unknown H3024C06 Mouse teratocarcinoma expressed serine rich (Tera) -0.453 0.617 -0.614 -0.187 H3041B12 Mouse TI-227 expressed in association with B16 melanoma metastasis -0.457 0.606 -0.649 -0.027 H3049D03 Mouse spinocerebellar ataxia 10 (Sca10) -0.475 0.48 -0.697 -0.237 H3099F09 Mouse pH 34, undifferentiated EC cells specific -0.568 0.175 -0.537 -0.596 H3099F10 Human candidate tumor suppressor gene 21 protein -0.541 0.282 -0.789 -0.059 H3100E06 Human breast carcinoma amplified sequence 1 -0.139 0.529 -0.833 -0.078 H3002A11 Human hypothetical protein -0.362 0.312 -0.867 0.135 H3041C04 Human cDNA clone -0.283 0.605 -0.741 -0.05 H3043G12 Human CGI (comparative gene identification)-73 protein -0.321 0.44 -0.827 -0.131 H3096H06 Human hypothetical protein -0.28 0.559 -0.382 -0.68 H3100H03 Human putative cDNA clone -0.578 0.492 -0.584 -0.285 H3106E06 Human KIAA1100 -0.676 0.671 -0.298 -0.051 H3005E08 -0.5 0.496 -0.643 -0.297 H3009B10 -0.307 0.492 -0.795 -0.176 H3009H01 -0.244 0.574 -0.634 -0.454 H3016C04 -0.567 0.604 -0.435 -0.349 H3016C06 -0.399 0.44 -0.78 -0.194 H3018E07 -0.622 0.57 -0.533 -0.048 H3018G07 -0.633 0.532 -0.373 -0.419 H3022C06 -0.525 0.67 -0.495 -0.169 H3022E11 -0.296 0.659 -0.588 -0.361 H3025F06 -0.553 0.622 -0.502 -0.231 H3025G08 -0.346 0.472 -0.804 -0.092 H3025H06 -0.352 0.495 -0.719 -0.334 H3030C10 -0.504 0.38 -0.766 0.112 H3030E01 -0.496 0.535 -0.632 -0.258 H3032E01 -0.116 0.567 -0.798 -0.163 H3033C09 -0.414 0.505 -0.689 -0.313 H3033E02 -0.402 0.51 -0.759 0 H3034C12 -0.63 0.555 -0.534 -0.087 H3034G03 -0.357 0.539 -0.689 -0.326 H3035A03 -0.31 0.738 -0.579 -0.148 H3036E03 -0.575 0.609 -0.54 -0.07 H3036G02 -0.552 0.397 -0.732 0.003 H3036G03 -0.664 0.479 -0.554 -0.147 H3036G05 -0.482 0.377 -0.786 -0.081 H3036G06 -0.438 0.574 -0.583 -0.368 H3036H04 -0.528 0.434 -0.713 -0.148 H3037C02 -0.249 0.388 -0.882 0.091 H3037C12 -0.273 0.431 -0.855 -0.083 H3038A04 -0.699 0.562 -0.118 -0.424 H3039D11 -0.503 0.472 -0.533 -0.488 H3043E12 -0.283 0.559 -0.749 -0.214 H3043H11 -0.599 0.437 -0.559 -0.368 H3044B04 -0.386 0.542 -0.487 -0.564 H3047G04 -0.206 0.541 -0.692 -0.429 H3048C12 -0.32 0.618 -0.628 -0.344 H3048D12 -0.36 0.515 -0.698 -0.341 H3048E12 -0.255 0.519 -0.779 -0.237 H3049B01 -0.705 0.533 -0.459 -0.081 H3057C12 -0.478 0.593 -0.569 -0.308 H3057E12 -0.378 0.569 -0.671 -0.284 H3057G04 -0.38 0.74 -0.417 -0.365 H3067E12 -0.321 0.548 -0.529 -0.562 H3072E11 -0.314 0.385 -0.848 -0.182 H3075C02 -0.231 0.481 -0.766 -0.357 H3075E02 -0.272 0.361 -0.882 -0.126 H3084B08 -0.446 0.559 -0.328 -0.615 H3088A04 -0.711 0.522 -0.372 -0.287 H3088G03 -0.56 0.67 -0.453 -0.174 H3094E04 -0.583 0.518 -0.623 -0.048 H3094F02 -0.464 0.53 -0.535 -0.464 H3094F05 -0.619 0.143 -0.649 -0.416 H3094G03 -0.696 0.5 -0.472 -0.204 H3095F07 -0.631 0.291 -0.7 -0.161 H3097F04 -0.752 0.507 -0.392 -0.148 H3097G02 -0.765 0.566 -0.19 -0.237 H3097G04 -0.425 0.341 -0.837 -0.027 H3099F07 -0.416 0.475 -0.581 -0.511 H3100A09 -0.252 0.639 -0.699 -0.193 H3100G01 -0.54 0.679 -0.142 -0.474 H3100H05 -0.534 0.524 -0.447 -0.489 H3108C10 -0.465 0.609 -0.401 -0.5 H3116B01 -0.594 0.674 -0.419 -0.128 H3116E03 -0.484 0.628 -0.393 -0.465 H3116G03 -0.342 0.55 -0.629 -0.428 H3117B08 -0.283 0.687 -0.439 -0.503 H3133E08 -0.461 0.574 -0.617 -0.273 H3134G03 -0.629 0.694 -0.142 -0.316 H3134G09 -0.02 0.683 -0.436 -0.584 H3154E11 -0.46 0.521 -0.57 -0.436 H3156C06 -0.529 0.542 -0.647 -0.078 H3157B11 -0.394 0.67 -0.368 -0.509 H3158D03 -0.642 0.45 -0.619 -0.021

Cluster #7 Apoptosis H3029A05 Mouse cellular apoptosis susceptibility protein -0.8 -0.37 0.174 0.437 H3153D07 Mouse p75NTR-associated cell death executor (Nade)/ Bex3 -0.73 -0.531 0.166 0.394

Cell Cycle H3027G03 Mouse cyclin B1 -0.912 -0.159 0.119 0.358

Transcription/Chromatin H3009F04 Mouse GATA-binding protein 2 (Gata2) -0.618 -0.657 0.178 0.39 H3014E10 Mouse transcription factor AP-2, gamma (Tcfap2c) -0.815 -0.467 -0.055 0.337 H3020C07 eHAND -0.639 -0.751 -0.031 0.16 H3027G05 Mouse placentae and embryos oncofetal gene (Pem) -0.931 -0.315 0.122 0.131 H3029A04 Mouse SCIP, myelin-specific POU-domain transcriptional repressor -0.789 -0.507 0.309 0.152 H3076B01 Mouse melanocyte-specific gene 1 (msg1) -0.889 -0.399 0.219 0.026 H3120B02 Mouse placenta specific homeobox 1 (Psx1) -0.839 -0.361 0.402 0.056 H3129D02 Mouse mSin3B -0.685 -0.618 0.373 0.091 H3134A06 Mouse period 3 (Per3), circadian oscillators -0.507 -0.644 0.363 0.441 H3142D02 Mouse upstream transcription factor 1 (Usf1) -0.814 -0.289 0.224 0.449

DNA Replication H3031D01 Mouse Orc1 origin recognition complex 1 -0.78 -0.447 0.436 0.027 H3090G04 Mouse bromodomain-containing FSH-like protein FSRG2 (Fsrg2) -0.484 -0.62 0.121 0.604 H3103E01 Mouse topoisomerase 3 alpha (Top3a) -0.841 -0.346 0.157 0.382 H3108A05 Mouse p53 tumor suppressor -0.699 -0.652 0.179 0.231 H3133D01 Mouse deoxyribonuclease II (Dnase2) -0.524 -0.689 0.345 0.361

Energy/Metabolism H3029A03 Mouse peroxisomal trans 2-enoyl CoA reductase -0.834 -0.453 0.278 0.141 H3032H02 Mouse phosphatidylcholine transfer protein-like (Pctpl) -0.818 -0.502 0.026 0.277 H3040B03 Mouse solute carrier family 9 (sodium/hydrogen exchanger) 3 regulator 1 (Slc9a3r1) -0.863 -0.389 0.092 0.306 H3129D05 Mouse nudix (nucleoside diphosphate linked moiety X)-type motif 5 (Nudt5) -0.765 -0.364 0.241 0.472 H3134D04 Mouse hexokinase -0.555 -0.713 0.048 0.424 H3085D10 Mouse guanine deaminase (Gda) -0.926 -0.35 0.137 -0.017 H3031G08 Putative human monocarbocylate transporter 6 -0.802 -0.414 -0.053 0.425

Matrix/Structural Proteins H3007G06 Mouse endoB cytokeratin -0.813 -0.534 0.189 0.128 H3014H12 Mouse Endo A cytokeratin -0.82 -0.515 0.021 0.246 H3017A12 Mouse synaptogyrin 1 (Syngr1) -0.847 -0.335 0.206 0.355 H3018E05 Mouse Endo A cytokeratin -0.894 -0.401 0.118 0.16 H3027G04 Mouse focal adhesion kinase (Fadk) -0.484 -0.675 0.022 0.555 H3031C01 Mouse EndoA cytokeratin -0.851 -0.464 0.208 0.126 H3031E01 Mouse tissue inhibitor of metalloproteinase 3 (Timp3) -0.783 -0.452 0.275 0.325 H3137A03 Mouse integrin alpha 3A -0.859 -0.332 0.176 0.344 H3137C06 Mouse transglutaminase (TGase) -0.558 -0.768 -0.05 0.309

Protein Synthesis/Translational Control H3100H12 Human eukaryotic translation elongation factor 1 epsilon 1 -0.775 -0.4 0.306 0.379 H3108A03 Mouse small intestine apolipoprotein B mRNA-editing component 1 (Apobec1) -0.74 -0.598 0.226 0.203 H3129C01 Mouse elongation factor 2 -0.459 -0.66 0.313 0.504 H3027H05 Mouse RNA polymerase 1-2 (128 kDa subunit) (Rpo1-2) -0.916 -0.168 0.349 0.102

Signal Transduction H3001A02 Mouse secretin (Sct) -0.911 -0.328 0.021 0.248 H3007D03 Mouse embryonal Fyn-associated substrate (Efs) -0.731 -0.606 -0.015 0.31 H3022F12 Mouse placental lactogen I (PL-I) -0.866 -0.426 -0.107 0.237 H3036E12 Human FGF receptor activating protein 1 (FRAG1) -0.905 -0.353 0.175 0.152 H3103D01 Mouse protein phosphatase 1, catalytic subunit, gamma (Ppp1cc) -0.864 -0.275 0.248 0.338 H3104D07 Mouse mammary-derived growth inhibitor (MDGI)/ fatty acid-binding protein -0.891 -0.38 0.232 0.083 H3108A04 Mouse sulfated glycoprotein-2 isoform 1/clustrin precursor -0.753 -0.585 0.138 0.264 H3142D06 Mouse pituitary tumor-transforming 1 (Pttg1) -0.728 -0.461 0.5 0.077

Unknown H3029A02 Mouse selective hybridizing clone (Shyc) expressed in nervous system -0.733 -0.52 0.194 0.391 H3108G04 Mouse cysteine rich intestinal protein (Crip) -0.654 -0.613 0.336 0.286 H3147B09 Human KIAA0308 -0.607 -0.518 0.322 0.507 H3017B12 Human cDNA clone -0.53 -0.71 0.144 0.44 H3017E06 Mouse EST from clone 643475 -0.853 -0.242 0.105 0.449 H3084E06 Human putative cDNA clone -0.736 -0.465 0.25 0.422 H3085G10 Human cDNA clone -0.881 -0.269 0.253 0.294 H3091F07 Human cDNA clone -0.919 -0.37 0.125 0.033 H3094D03 Human putative cDNA clone -0.888 -0.255 0.276 0.261 H3101E04 Human putative cDNA clone -0.584 -0.627 0.174 0.483 H3102F11 Mouse brain cDNA clone MNCb-3154 -0.925 -0.361 0.098 0.045 H3129D09 Human cDNA clone -0.442 -0.707 0.102 0.541 H3132D09 Human putative cDNA clone -0.627 -0.64 0.036 0.44 H3134D02 Human hypothetical protein -0.859 -0.26 0.175 0.401 H3025C01 Human KIAA0697 -0.931 -0.238 0.222 0.159 H3001A06 -0.734 -0.618 0.212 0.179 H3009H12 -0.59 -0.506 -0.079 0.623 H3018C05 -0.708 -0.612 0.279 0.21 H3018E04 -0.657 -0.495 0.351 0.446 H3020E07 -0.594 -0.76 0.075 0.249 H3027G06 -0.794 -0.418 -0.002 0.44 H3036H12 -0.904 -0.311 0.188 0.221 H3041A06 -0.62 -0.524 -0.325 0.483 H3052E12 -0.439 -0.79 0.039 0.424 H3065G12 -0.785 -0.393 0.461 0.122 H3082F11 -0.748 -0.645 0.126 -0.088 H3092D01 -0.868 -0.48 0.022 0.118 H3101A07 -0.865 -0.282 0.244 0.334 H3104B05 -0.758 -0.642 0.085 0.068 H3104C08 -0.739 -0.389 0.145 0.528 H3104D09 -0.736 -0.641 0.123 -0.173 H3104F07 -0.697 -0.607 0.378 0.011 H3105B05 -0.928 -0.347 0.087 0.093 H3122D08 -0.681 -0.434 0.191 0.557 H3122E09 -0.805 -0.28 0.163 0.494 H3132H09 -0.907 -0.277 0.231 0.215 H3134E07 -0.571 -0.648 -0.21 0.455 H3137G04 -0.807 -0.341 0.287 0.386 H3142F04 -0.876 -0.292 0.313 0.218 H3142F11 -0.896 -0.326 0.028 0.299 H3142H02 -0.676 -0.57 0.21 0.414 H3142H03 -0.667 -0.43 -0.036 0.606 H3146B05 -0.726 -0.472 0.052 0.496 H3147D08 -0.764 -0.397 0.414 0.293 H3153C08 -0.767 -0.357 0.124 0.517 H3153E01 -0.552 -0.733 -0.117 0.377 H3036G11 -0.958 -0.141 0.123 0.212 H3038B03 -0.913 -0.348 0.208 -0.001

Cluster #13 Cell Cycle H3105B10 Mouse cyclin B1 -0.976 0.094 0.191 0.014

Cluster #12 Transcription/Chromatin H3116E09 Human core histone macro H2A2.2 -0.879 0.061 0.05 0.468 12 H3117D05 Mouse myeloid ecotropic viral integration site 1 (Meis1), PBX/exd homeobox family -0.876 0.221 -0.096 0.415 12 H3130G01 Putative human transcription intermediary factor 1-alpha -0.824 0.323 -0.215 0.411

12 DNA Replication H3138E05 Mouse mCDC47 member of the minichromosome maintenance (Mcm) family -0.951 0.242 0.148 0.12 12 H3139A05 Mouse topoisomerase (DNA) II alpha (Top2a) -0.854 0.208 -0.141 0.453 12 H3142D07 Mouse p53 cellular tumor antigen -0.953 0.063 0.175 0.236 12 Energy/Metabolism H3122F01 Human ATP synthase beta subunit -0.918 0.293 0.214 0.155 12 H3128G04 Mouse lactate dehydrogenase 2B -0.945 0.116 0.057 0.297 13 H3135D06 Mouse galactose-1-phosphate uridyltransferase (GALT) -0.914 0.049 0.356 0.184 13 H3135F07 Putative mouse threonyl-tRNA synthetasse -0.959 0.095 0.247 0.091 12 H3135G07 Mouse protoporphyrinogen oxidase (Ppox) -0.932 0.047 0.193 0.301 12 H3142H07 Mouse N-acetylglucosamine galactosyltransferase -0.896 0.388 -0.025 0.211

13 Matrix/Structural Proteins H3016D10 Murine L-34 galactoside-binding lectin -0.894 0.4 0.196 -0.033 12 H3027D08 Rat nucleoporin p58 -0.856 0.183 -0.158 0.455 13 H3106E04 Mouse preprotein translocase TIM22, nuclear gene for mitochondrial inner membrane -0.876 0.231 0.418 -0.058 12 H3127D04 Mouse histidine rich calcium binding protein (Hrc) -0.906 0.025 0.174 0.384 12 H3135F08 Human kinesin family member C3 -0.948 0.112 0.12 0.269

12 Protein Synthesis/Translational Control H3127E04 Rat RNA polymerase II -0.874 0.337 -0.132 0.322 12 H3135E07 Mouse ubiquitin-activating enzyme E1, Chr X (Ube1x) -0.88 0.099 -0.103 0.451 12 H3135H08 Mouse Trf-proximal protein (Trfp) -0.96 0.116 0.183 0.175

12 Signal Transduction H3027F11 Mouse fibroblast growth factor inducible 13 (Fin13) -0.952 0.194 0.038 0.229 12 H3029G05 Mouse diacylglycerol kinase alpha (Dagk1) -0.944 0.193 0.171 0.201 12 H3041D03 Mouse myo-inositol 1-phosphate synthase A1 (IsynA1) -0.917 0.374 0.1 0.086 12 H3129G03 Rat T cell receptor eta chain -0.926 0.337 0.107 0.125 13 H3131F06 Mouse developmentally regulated GTP-binding protein 1 (Drg1) -0.892 0.106 0.428 0.087

13 Unknown H3135D08 Mouse def-8, differentially expressed in haemopoietic progenitor cells -0.947 0.265 0.163 0.068 12 H3135H07 Human proline and glutamic acid rich nuclear protein isoform -0.953 0.058 0.216 0.201 12 H3016A12 -0.919 0.35 0.145 0.1 12 H3031A05 -0.859 0.117 -0.172 0.467 12 H3031E09 -0.931 0.134 -0.041 0.336 12 H3033F10 -0.822 0.237 -0.242 0.456 12 H3035D07 -0.995 0.033 0.014 0.083 13 H3104C09 -0.868 0.039 0.492 -0.022 12 H3112B09 -0.948 0.215 0.18 0.146 13 H3112C11 -0.908 0.141 0.34 0.196 12 H3116B03 -0.857 0.123 -0.111 0.487 12 H3123B11 -0.908 0.242 0.055 0.336 12 H3130D07 -0.906 0.146 -0.054 0.392 12 H3134D08 -0.821 0.14 -0.248 0.493 12 H3135A08 Human cDNA clone -0.812 0.251 -0.253 0.459 12 H3135C07 -0.941 0.257 0.162 0.144 12 H3135E08 -0.912 0.157 -0.03 0.375 12 H3135G08 -0.913 0.145 -0.053 0.376 12 H3135H06 -0.962 0.147 0.087 0.21 12 H3137B10 -0.919 0.156 0.026 0.359 12 H3141B02 -0.929 0.221 0.131 0.263 12 H3141B08 -0.886 0.352 -0.099 0.282 12 H3141H08 Human KIAA0664 -0.9 0.38 0.028 0.206 12 H3141H09 Human HSPC (CD34+ hematopoietic stem/progenitor cells)-227 protein -0.854 0.228 -0.149 0.442 12 H3144C03 -0.889 0.066 0.125 0.434

Cluster #14 Transcription/Chromatin H3009E05 Mouse lens epithelium-derived growth factor (ledgf) / transcriptional co-activator p53 0.632 -0.656 -0.111 -0.395 DNA Replication H3003A05 Mouse Orc4 origin recognition complex 4 0.452 -0.796 -0.249 -0.313

Energy/Metabolism H3009G06 Mouse 3'-phosphoadenosine 5'-phosphosulfate synthase 1 0.674 -0.692 -0.144 -0.21 H3020A12 Human high density lipoprotein binding protein (vigilin) 0.725 -0.42 -0.365 -0.402 H3138G09 Mouse alpha glucosidase 2 alpha 0.526 -0.801 -0.159 -0.235 H3141A01 GARS domain for mouse monofunctional GARS and trifunctional GARS-AIRS-GART 0.598 -0.787 0.002 -0.149

Heat Shock/Stress H3003F12 Mouse BiP kinship with the 70-kDa heat shock protein family 0.518 -0.759 -0.39 -0.031 H3095E06 Mouse glutathione S-transferase like (Gsttl) 0.436 -0.743 -0.268 -0.429

Matrix/Structural Proteins H3007D09 Mouse polymyositis/scleroderma autoantigen 2 (Pmscl2) 0.769 -0.416 -0.417 -0.243 H3008A09 Rat rhoB 0.375 -0.803 -0.455 0.075 H3009D05 Mouse galactose binding lectin soluble 1 (Lgals1) 0.459 -0.739 -0.11 -0.479 H3009F05 Chinese hamster phosphatidylserine decarboxylase 0.449 -0.727 -0.108 -0.506 H3014C06 Mouse beta-2 microglobulin (B2m) 0.338 -0.918 -0.075 -0.191 H3014C08 Mouse surfeit gene 4 (Surf4)/ ER membrane protein 0.384 -0.919 -0.071 0.03 H3016C05 Mouse annexin A5 (Anxa5) 0.268 -0.963 -0.003 0.005 H3017F05 Mouse lamin A (Lmna) 0.506 -0.825 -0.162 -0.187 H3019A08 Mouse actin-related protein complex 1b (Arpc1b) 0.475 -0.878 -0.05 -0.026 H3021G11 Mouse calreticulin (Calr) 0.65 -0.442 -0.57 -0.235 H3022G07 Mouse galactose binding lectin soluble 1 (Lgals1) 0.455 -0.813 -0.177 -0.315 H3037A03 Human alpha-actinin 0.632 -0.433 -0.524 -0.371 H3052F04 Mouse selectin, endothelial cell, ligand (Selel) 0.603 -0.736 -0.254 -0.169 H3080A11 Mouse tetraspanin membrane protein CD63 0.495 -0.727 -0.069 -0.469 H3095H05 Mouse pleckstrin homology, Sec7 and coiled/coil domains 3 (Pscd3)/ Grp1 0.316 -0.673 -0.666 0.043 H3119E05 Mouse tetraspanin membrane protein CD63 0.587 -0.647 -0.315 -0.369 H3120G06 Mouse tropomyosin isoform 2 0.571 -0.681 -0.262 -0.374 H3127D03 Mouse decorin/ proteoglycan PGI 0.6 -0.6 -0.311 -0.426 H3134H10 Murine integrin beta 0.731 -0.559 -0.166 -0.352 H3135G03 Mouse serine protease inhibitor 3 (Spi3) 0.444 -0.86 0.005 -0.247 H3136A08 Mouse microfibrillar-associated protein 2 (Mfap2) 0.579 -0.691 -0.189 -0.388 H3136G02 Mouse non-muscle myosin light chain 3 (MLC3nm) 0.67 -0.56 -0.485 -0.018 H3143A02 Mouse prothymosin beta 4 (Ptmb4)/ actin monomer-sequestering proteins 0.479 -0.557 -0.669 -0.105 H3151G09 Mouse protocadherin 13 (Pcdh13) 0.437 -0.511 -0.556 -0.487 H3152D11 Mouse vesicle transport through interaction with t-SNAREs 1b homolog (Vti1b) 0.781 -0.419 -0.357 -0.293 H3155B02 Mouse calumenin (Calu) 0.546 -0.741 -0.06 -0.385

Signal Transduction H3003A03 Mouse beta-galactoside binding protein (negative growth factor) 0.428 -0.816 -0.204 -0.328 H3003F07 Mouse calmodulin (Calm) 0.53 -0.815 0.052 -0.227 H3003H01 Mouse adenylate cyclase 7 0.431 -0.812 -0.089 -0.38 H3008A08 Mouse maternal embryonic leucine zipper kinase (Melk) 0.46 -0.815 -0.324 0.131 H3014H10 Mouse tumor differentially expressed 1, like (Tde1l)/ TMS2 0.427 -0.779 -0.078 -0.45 H3024A05 Mouse secreted acidic cysteine rich glycoprotein (Sparc) 0.374 -0.702 -0.352 -0.491 H3053E03 Mouse small GTPase (Gtr2) 0.662 -0.598 -0.406 -0.193 H3054C02 Mouse growth arrest and DNA-damage-inducible, gamma (Gadd45g) 0.561 -0.563 -0.438 -0.418 H3054E01 Mouse RAS p21 protein activator 3 (Rasa3) 0.506 -0.823 -0.251 -0.037 H3055C08 Mouse small GTPase (Gtr2) 0.677 -0.442 -0.519 -0.273 H3113D09 Mouse myristoylated alanine rich protein kinase C substrate (Macs) 0.602 -0.698 -0.283 -0.262 H3116A04 Mouse secreted acidic cysteine rich glycoprotein (Sparc) 0.698 -0.577 -0.146 -0.396 H3120G02 Mouse G protein Gi2 alpha 0.719 -0.617 -0.158 -0.276 H3138H09 Mouse cathepsin D 0.567 -0.688 -0.344 -0.292 H3138H10 Mouse cathepsin D 0.554 -0.713 -0.242 -0.353 H3149F11 Mouse serpentine receptor, secretin receptor member with transmembrane domains 0.237 -0.672 -0.496 -0.494 H3152F05 Mouse adhesion-related tyrosine-kinase receptor UFO precursor 0.157 -0.968 -0.047 -0.188

Unknown H3003A01 Human putative cDNA clone 0.504 -0.728 -0.381 -0.264 H3003A02 Human cDNA clone 0.566 -0.721 -0.333 -0.218 H3009A06 Human Arginine-rich protein 0.463 -0.859 -0.194 0.097 H3009E04 Mouse En-2/lacZ junction mRNA (Gt10) 0.43 -0.865 0.085 -0.242 H3132A02 Mouse breast cancer associated 1 protein 0.521 -0.742 -0.419 0.04 H3132G03 Mouse brain protein 44-like protein (Brp44l) 0.575 -0.783 -0.084 -0.217 H3003A04 Human putative cDNA clone 0.464 -0.796 -0.253 -0.292 H3007C03 Human putative cDNA clone 0.577 -0.729 -0.164 -0.327 H3017E02 Human putative cDNA clone 0.49 -0.85 -0.183 0.044 H3022G05 Human CGI (comparative gene identification)-34 protein 0.474 -0.771 -0.265 -0.329 H3055C02 Mouse brain cDNA clone MNCb-3925 0.639 -0.63 -0.432 -0.077 H3136F01 Human putative cDNA clone 0.694 -0.58 -0.416 -0.087 H3137E06 Human putative cDNA clone 0.641 -0.681 -0.352 -0.011 H3138G10 Human KIAA0650 0.631 -0.649 -0.026 -0.423 H3141G02 Human putative cDNA clone 0.582 -0.526 -0.516 -0.342 H3153G07 Human putative cDNA clone 0.672 -0.604 -0.407 -0.128 H3003A06 0.555 -0.722 -0.267 -0.313 H3014G05 0.512 -0.702 -0.294 -0.395 H3121C10 0.469 -0.806 -0.351 0.081 H3136E02 0.568 -0.788 -0.028 -0.231 H3136G11 0.62 -0.643 -0.175 -0.411 H3136H02 0.699 -0.664 -0.25 -0.084 H3137D12 0.734 -0.525 -0.158 -0.399 H3140A03 0.478 -0.734 -0.081 -0.474 H3143A03 0.543 -0.612 -0.571 -0.051 H3151C03 0.56 -0.697 -0.047 -0.442