Table 3. Signature genes. Normalized Average Expression Level kmean Function Clone Name Putative Identification FI ES TS3 TS6 Cluster #4 Apoptosis H3035A01 Mouse tumor necrosis factor, alpha-induced protein 2 (Tnfaip2)/ B94 -0.487 0.781 -0.269 -0.28 H3100E04 Mouse inhibitor of apoptosis protein 1 -0.404 0.56 -0.713 -0.117 Cell Cycle H3019C10 Mouse prohibitin (Phb), antiproliferative protein -0.702 0.67 -0.177 -0.162 H3025D07 Mouse Ki-67 -0.115 0.539 -0.592 -0.586 H3116H01 Mouse CDC10 -0.21 0.53 -0.619 -0.539 Transcription/Chromatin H3016B10 Human leucine zipper, down-regulated in cancer 1 (LDOC1) -0.627 0.6 -0.485 0.1 H3036F04 Mouse REX-1 -0.647 0.558 -0.445 -0.264 H3086G02 Mouse DNA methyltransferase 3A (Dnmt3a) -0.669 0.576 -0.328 -0.333 H3105D05 Mouse zinc finger protein 57 (Zfp57) -0.82 0.51 -0.216 -0.138 H3128E07 Mouse cysteine-rich protein 2 CRP2/SmLIM -0.344 0.662 -0.656 -0.111 DNA Replication H3039G12 Mouse 5'-3' exoribonuclease 1 (Xrn1)/Dhm2 -0.192 0.632 -0.575 -0.48 H3064A08 Human replication factor C3 -0.495 0.703 -0.507 -0.04 Energy/Metabolism H3021A12 Mouse tryptophan-tRNA ligase -0.607 0.56 -0.56 -0.058 H3040F06 Mouse Mpv17 transgene, kidney disease mutant (Mpv17), peroxisomal protein -0.453 0.542 -0.699 -0.106 H3043F12 Mouse ferrochelatase (Fech)/ protoheme ferrolyase -0.466 0.514 -0.662 -0.279 H3047F02 Mouse vacuolar-adenosine trisphosphatase -0.596 0.308 -0.734 -0.092 H3075A04 Putative sheep protein-arginine deiminase typeIII -0.022 0.422 -0.906 -0.013 H3090E05 Mouse P450 (cytochrome) oxidoreductase (Por) -0.332 0.564 -0.534 -0.533 H3119G08 Mouse glutathione S-transferase alpha 4 (Gsta4) -0.544 0.477 -0.673 0.146 Heat Shock/Stress H3013D11 Mouse metallothionein II -0.286 0.528 -0.796 0.068 Heat Shock/Stress H3023G01 Mouse heat shock protein 86 kDa 1 (Hsp86-1) -0.659 0.632 -0.076 -0.398 Matrix/Structural Proteins H3015H02 Mouse serine protease inhibitor 6 (Spi6) -0.514 0.66 -0.545 -0.036 H3035B02 Mouse skeletal muscle alpha tropomyosin -0.297 0.676 -0.672 -0.033 H3093F11 Human secretory carrier membrane protein 1 (SCAMP1) -0.414 0.138 -0.884 -0.165 H3097E02 Mouse EH-domain containing protein 2 (Ehd2) -0.355 0.34 -0.869 0.04 H3100F04 Putative human beta-tryptase precursor -0.706 0.527 -0.43 -0.193 H3101B07 Mouse brain neurofilament-L -0.618 0.135 -0.646 -0.426 H3104H03 Putative mouse kinesin-like protein KIF1A -0.763 0.508 -0.37 -0.147 H3116G01 Mouse nuclear pore complex glycoprotein p62 -0.304 0.6 -0.535 -0.509 H3135C02 Mouse galectin-7 keratinocyte lectin -0.34 0.788 -0.411 -0.305 Protein Synthesis/Translational Control H3037E02 Human putative pre-mRNA splicing factor, ATP-dependent RNA helicase -0.329 0.653 -0.402 -0.55 H3073A06 Mouse beta-transducin repeat containing protein/F-box/WD40-repeat protein FWD1 -0.437 0.311 -0.841 0.053 H3135B05 Mouse beta-transducin repeat containing protein/F-box/WD40-repeat protein FWD1 -0.02 0.637 -0.676 -0.367 Signal Transduction H3005F06 Mouse interleukin 1 receptor-associated kinase (Il1rak) -0.187 0.536 -0.803 -0.177 H3035B01 Human putative phosphoprotein C8FW -0.3 0.772 -0.278 -0.484 H3062G12 Mouse large tumor suppressor 1 (Lats1) putative protein kinase -0.407 0.38 -0.817 0.145 H3064C02 Mouse large tumor suppressor 1 (Lats1) putative protein kinase -0.383 0.618 -0.634 -0.26 H3088G02 Human GTP-binding protein (NGB) -0.615 0.527 -0.571 -0.131 H3126B12 Mouse protein kinase inhibitor, gamma (Pkig) -0.674 0.588 -0.437 -0.085 H3136E09 Mouse Rho-associated coiled-coil forming kinase 1 (Rock1) -0.185 0.751 -0.439 -0.455 Unknown H3024C06 Mouse teratocarcinoma expressed serine rich (Tera) -0.453 0.617 -0.614 -0.187 H3041B12 Mouse TI-227 expressed in association with B16 melanoma metastasis -0.457 0.606 -0.649 -0.027 H3049D03 Mouse spinocerebellar ataxia 10 (Sca10) -0.475 0.48 -0.697 -0.237 H3099F09 Mouse pH 34, undifferentiated EC cells specific -0.568 0.175 -0.537 -0.596 H3099F10 Human candidate tumor suppressor gene 21 protein -0.541 0.282 -0.789 -0.059 H3100E06 Human breast carcinoma amplified sequence 1 -0.139 0.529 -0.833 -0.078 H3002A11 Human hypothetical protein -0.362 0.312 -0.867 0.135 H3041C04 Human cDNA clone -0.283 0.605 -0.741 -0.05 H3043G12 Human CGI (comparative gene identification)-73 protein -0.321 0.44 -0.827 -0.131 H3096H06 Human hypothetical protein -0.28 0.559 -0.382 -0.68 H3100H03 Human putative cDNA clone -0.578 0.492 -0.584 -0.285 H3106E06 Human KIAA1100 -0.676 0.671 -0.298 -0.051 H3005E08 -0.5 0.496 -0.643 -0.297 H3009B10 -0.307 0.492 -0.795 -0.176 H3009H01 -0.244 0.574 -0.634 -0.454 H3016C04 -0.567 0.604 -0.435 -0.349 H3016C06 -0.399 0.44 -0.78 -0.194 H3018E07 -0.622 0.57 -0.533 -0.048 H3018G07 -0.633 0.532 -0.373 -0.419 H3022C06 -0.525 0.67 -0.495 -0.169 H3022E11 -0.296 0.659 -0.588 -0.361 H3025F06 -0.553 0.622 -0.502 -0.231 H3025G08 -0.346 0.472 -0.804 -0.092 H3025H06 -0.352 0.495 -0.719 -0.334 H3030C10 -0.504 0.38 -0.766 0.112 H3030E01 -0.496 0.535 -0.632 -0.258 H3032E01 -0.116 0.567 -0.798 -0.163 H3033C09 -0.414 0.505 -0.689 -0.313 H3033E02 -0.402 0.51 -0.759 0 H3034C12 -0.63 0.555 -0.534 -0.087 H3034G03 -0.357 0.539 -0.689 -0.326 H3035A03 -0.31 0.738 -0.579 -0.148 H3036E03 -0.575 0.609 -0.54 -0.07 H3036G02 -0.552 0.397 -0.732 0.003 H3036G03 -0.664 0.479 -0.554 -0.147 H3036G05 -0.482 0.377 -0.786 -0.081 H3036G06 -0.438 0.574 -0.583 -0.368 H3036H04 -0.528 0.434 -0.713 -0.148 H3037C02 -0.249 0.388 -0.882 0.091 H3037C12 -0.273 0.431 -0.855 -0.083 H3038A04 -0.699 0.562 -0.118 -0.424 H3039D11 -0.503 0.472 -0.533 -0.488 H3043E12 -0.283 0.559 -0.749 -0.214 H3043H11 -0.599 0.437 -0.559 -0.368 H3044B04 -0.386 0.542 -0.487 -0.564 H3047G04 -0.206 0.541 -0.692 -0.429 H3048C12 -0.32 0.618 -0.628 -0.344 H3048D12 -0.36 0.515 -0.698 -0.341 H3048E12 -0.255 0.519 -0.779 -0.237 H3049B01 -0.705 0.533 -0.459 -0.081 H3057C12 -0.478 0.593 -0.569 -0.308 H3057E12 -0.378 0.569 -0.671 -0.284 H3057G04 -0.38 0.74 -0.417 -0.365 H3067E12 -0.321 0.548 -0.529 -0.562 H3072E11 -0.314 0.385 -0.848 -0.182 H3075C02 -0.231 0.481 -0.766 -0.357 H3075E02 -0.272 0.361 -0.882 -0.126 H3084B08 -0.446 0.559 -0.328 -0.615 H3088A04 -0.711 0.522 -0.372 -0.287 H3088G03 -0.56 0.67 -0.453 -0.174 H3094E04 -0.583 0.518 -0.623 -0.048 H3094F02 -0.464 0.53 -0.535 -0.464 H3094F05 -0.619 0.143 -0.649 -0.416 H3094G03 -0.696 0.5 -0.472 -0.204 H3095F07 -0.631 0.291 -0.7 -0.161 H3097F04 -0.752 0.507 -0.392 -0.148 H3097G02 -0.765 0.566 -0.19 -0.237 H3097G04 -0.425 0.341 -0.837 -0.027 H3099F07 -0.416 0.475 -0.581 -0.511 H3100A09 -0.252 0.639 -0.699 -0.193 H3100G01 -0.54 0.679 -0.142 -0.474 H3100H05 -0.534 0.524 -0.447 -0.489 H3108C10 -0.465 0.609 -0.401 -0.5 H3116B01 -0.594 0.674 -0.419 -0.128 H3116E03 -0.484 0.628 -0.393 -0.465 H3116G03 -0.342 0.55 -0.629 -0.428 H3117B08 -0.283 0.687 -0.439 -0.503 H3133E08 -0.461 0.574 -0.617 -0.273 H3134G03 -0.629 0.694 -0.142 -0.316 H3134G09 -0.02 0.683 -0.436 -0.584 H3154E11 -0.46 0.521 -0.57 -0.436 H3156C06 -0.529 0.542 -0.647 -0.078 H3157B11 -0.394 0.67 -0.368 -0.509 H3158D03 -0.642 0.45 -0.619 -0.021 Cluster #7 Apoptosis H3029A05 Mouse cellular apoptosis susceptibility protein -0.8 -0.37 0.174 0.437 H3153D07 Mouse p75NTR-associated cell death executor (Nade)/ Bex3 -0.73 -0.531 0.166 0.394 Cell Cycle H3027G03 Mouse cyclin B1 -0.912 -0.159 0.119 0.358 Transcription/Chromatin H3009F04 Mouse GATA-binding protein 2 (Gata2) -0.618 -0.657 0.178 0.39 H3014E10 Mouse transcription factor AP-2, gamma (Tcfap2c) -0.815 -0.467 -0.055 0.337 H3020C07 eHAND -0.639 -0.751 -0.031 0.16 H3027G05 Mouse placentae and embryos oncofetal gene (Pem) -0.931 -0.315 0.122 0.131 H3029A04 Mouse SCIP, myelin-specific POU-domain transcriptional repressor -0.789 -0.507 0.309 0.152 H3076B01 Mouse melanocyte-specific gene 1 (msg1) -0.889 -0.399 0.219 0.026 H3120B02 Mouse placenta specific homeobox 1 (Psx1) -0.839 -0.361 0.402 0.056 H3129D02 Mouse mSin3B -0.685 -0.618 0.373 0.091 H3134A06 Mouse period 3 (Per3), circadian oscillators -0.507 -0.644 0.363 0.441 H3142D02 Mouse upstream transcription factor 1 (Usf1) -0.814 -0.289 0.224 0.449 DNA Replication H3031D01 Mouse Orc1 origin recognition complex 1 -0.78 -0.447 0.436 0.027 H3090G04 Mouse bromodomain-containing FSH-like protein FSRG2 (Fsrg2) -0.484 -0.62 0.121 0.604 H3103E01 Mouse topoisomerase 3 alpha (Top3a) -0.841 -0.346 0.157 0.382 H3108A05 Mouse p53 tumor suppressor -0.699 -0.652 0.179 0.231 H3133D01 Mouse deoxyribonuclease II (Dnase2) -0.524 -0.689 0.345 0.361 Energy/Metabolism H3029A03 Mouse peroxisomal trans 2-enoyl CoA reductase -0.834 -0.453 0.278 0.141 H3032H02 Mouse phosphatidylcholine transfer protein-like (Pctpl) -0.818 -0.502 0.026 0.277 H3040B03 Mouse solute carrier family 9 (sodium/hydrogen exchanger) 3 regulator 1 (Slc9a3r1) -0.863 -0.389 0.092 0.306 H3129D05 Mouse nudix (nucleoside diphosphate linked moiety X)-type motif 5 (Nudt5) -0.765 -0.364 0.241 0.472 H3134D04 Mouse hexokinase -0.555 -0.713 0.048 0.424 H3085D10 Mouse guanine deaminase (Gda) -0.926 -0.35 0.137 -0.017 H3031G08 Putative human monocarbocylate transporter 6 -0.802 -0.414 -0.053 0.425 Matrix/Structural Proteins H3007G06 Mouse endoB cytokeratin -0.813 -0.534 0.189 0.128 H3014H12 Mouse Endo A cytokeratin -0.82 -0.515 0.021 0.246 H3017A12 Mouse synaptogyrin 1 (Syngr1) -0.847 -0.335 0.206 0.355 H3018E05 Mouse Endo A cytokeratin -0.894 -0.401 0.118 0.16 H3027G04 Mouse focal adhesion kinase (Fadk) -0.484 -0.675 0.022 0.555 H3031C01 Mouse EndoA cytokeratin -0.851 -0.464 0.208 0.126 H3031E01 Mouse tissue inhibitor of metalloproteinase 3 (Timp3) -0.783 -0.452 0.275 0.325 H3137A03 Mouse integrin alpha 3A -0.859 -0.332 0.176 0.344 H3137C06 Mouse transglutaminase (TGase) -0.558 -0.768