DOCSLIB.ORG

Single Nucleotide Polymorphisms (Snps) of COL1A1 and COL11A1 in Class II Skeletal Malocclusion of Ethnic Javanese Patient

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Single Nucleotide Polymorphisms (Snps) of COL1A1 and COL11A1 in Class II Skeletal Malocclusion of Ethnic Javanese Patient Clinical, Cosmetic and Investigational Dentistry Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH Single Nucleotide Polymorphisms (SNPs) of COL1A1 and COL11A1 in Class II Skeletal Malocclusion of Ethnic Javanese Patient This article was published in the following Dove Press journal: Clinical, Cosmetic and Investigational Dentistry I Gusti Aju Wahju Ardani1 Background: The prevalence of malocclusion cases in the orthodontic specialist clinic in Aulanni’am2 Airlangga University’s Dental Hospital in Surabaya, Indonesia, in 2014–2016 is fairly high, Indeswati Diyatri3 as 55.34% of the occurrences were identified as class II skeletal malocclusion. This type of skeletal malocclusion, which is usually recognized in adults, occurs as a result of variation 1Orthodontics Department, Faculty of Dental Medicine, Airlangga University, during growth and development. Lately, there have been many reports on gene polymorph- Surabaya, Indonesia; 2Biochemistry isms of COL1A1 and COL11A1, which are assumed to be associated with class II skeletal Department, Faculty of Veterinary malocclusion in Caucasians. Medicine, Brawijaya University, Malang, Indonesia; 3Oral Biology, Faculty of Purpose: This study aims to analyze the relationship between single nucleotide polymorph- Dental Medicine, Airlangga University, isms (SNPs) of COL1A1 and COL11A1 with class II skeletal malocclusion in Javanese Surabaya, Indonesia ethnic group patients with mandibular micrognathism. Materials and Methods: The diagnosis of class II skeletal malocclusion was established using the lateral cephalometric radiographs (ANB angle ≥4°) (n=50). DNA was extracted from the patient’s peripheral blood. After that, PCR, electrophoresis, and DNA sequencing were conducted on the extracted DNA based on COL1A1 and COL11A1 primers. Results: The SNPs in COL1A1 are c.20980G/A in 27 patients and c.20980G>A in 8 patients, whereas SNPs in COL11A1 are both c.134373C/A and c.134555C/T in 8 patients and both c.[134373A>C] and c.134582G>A in 10 patients. All samples show the deletion (c. [134227delA]) in COL11A1. Conclusion: SNPs in COL1A1 and COL11A1 have been found in class II skeletal mal- occlusion of Javanese ethnic group patients. Seventy percent of SNPs in COL1A1 occur in rs.2249492, whereas 36% of newly discovered SNPs appear in COL11A1. All samples also have deletion in COL11A1. Keywords: COL1A1, COL11A1, class II malocclusion, mandibular micrognathism, ethnic Javanese Introduction Class II skeletal malocclusion is defined as a distal relation of mandible to the maxilla and has both sagittal anomaly and vertical anomaly characteristics.1 Class II skeletal malocclusion with anteroposterior skeletal anomaly, which is shown by ANB angle 2 Correspondence: I Gusti Aju Wahju 6.42 ± 1.70°, presents maxillary and mandibular disharmony to the cranial base. Ardani Moreover, there are two divisions of class II skeletal malocclusion: division one Orthodontics Department, Faculty of Dental Medicine, Airlangga University, and division two. Dental characteristics of division one class II skeletal malocclu- Surabaya, Indonesia sion are maxillary protrusion, a deep bite, and a large overbite, whereas division Tel +623 15030255 Email [email protected] two is characterized by a deep bite with maxillary central incisors proclination and submit your manuscript | www.dovepress.com Clinical, Cosmetic and Investigational Dentistry 2020:12 173–179 173 DovePress © 2020 Ardani et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. – http://doi.org/10.2147/CCIDE.S247729 php and incorporate the Creative Commons Attribution Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Ardani et al Dovepress lateral incisors retroclination or retroclination of all max- group population, which belongs to the Deutero – Malay illary incisors. However, most patients with class II skele- race who have special characteristics of class II skeletal tal malocclusion in Airlangga University Dental Hospital malocclusion with short mandibles. It also determined (AUDH) have special characteristics which make them whether the SNPs of COL1A1 and COL11A1, which is different from the typical class II skeletal malocclusions found in Caucasian’s class II skeletal malocclusion, are in Caucasians. Most patients have not only a deep bite, but also found in the Javanese population. This study aims to also protrusion of both maxilla and mandible, therefore the analyze the relationship between the SNPs of COL1A1 and overjet is not too large. Protrusion on maxilla only are COL11A1 with class II skeletal malocclusion in Javanese rarely found. The results of previous studies showed that ethnic group patients with mandibular micrognathism. class II skeletal malocclusion in AUDH increased ANB which, for the most part, was not caused by the increased Materials and Methods SNA (82.34 ± 3.49°). It was due to the decreased SNB This research was conducted at the Airlangga University (75.91 ± 3.77°). Based on McNamara analysis, class II Dental Hospital in Surabaya, Indonesia, from April 2015 skeletal malocclusion cases with a short mandible (107.87 to April 2016. This study was approved by the Ethical ± 8.55 mm) was found more often than the exceeded Clearance Committee of the Faculty of Dental Medicine, maxillary length.3,4 This result is consistent with class II Airlangga University with the reference number 059/ skeletal malocclusion characteristics in the Brazilian popu- HRECC.FODM/V/2018. The inclusion sample criteria of lation, whose mandibular length is 107.87 ± 8.54 mm.5 this study were Javanese men and women, aged between However, studies on other ethnic groups show different 15–35 years old, who had never had any previous ortho- results, such as in French Canadian, Italian, and Iraqi dontic treatment and all permanent teeth had erupted populations.6–8 except for the third molar. Fifty patients fulfilled the inclu- Meanwhile, the patterns and direction of skeletal sion criteria and agreed to become samples in this study. growth can be identified by examining the profile photo, All participants, and a parent/legal guardian of participants cephalometric radiograph, and cast model. However, class under the age of 18 years provided written informed con- II skeletal malocclusion cases are mostly diagnosed once sent, and that this study was conducted in accordance with patients have reached adulthood. The late diagnosis of the Declaration of Helsinki. skeletal malocclusion limits treatment options to camou- Class II skeletal malocclusion was determined using the flage orthodontic treatment or orthognathic surgery. On the digital cephalometric tracing (OrthoVision - 2017, South other hand, an earlier diagnosis enables any growth mod- Korea). Anatomical landmarks (such as: N, S, A, B, Ba, ification treatment to be performed on children or teen- Gn, Co) were determined manually using the cephalometric agers, which provides a shorter treatment duration and analysis software (Figure 1). DNA extraction was done using relatively more stable result compared to those diagnosed QiaAmp Blood Mini Kit (Qiagen), as instructed by standard later as adults. Dental and skeletal malocclusion that left blood-DNA extraction protocol. DNA amplification was untreated can lead to temporomandibular disorder (TMD) completed using the PCR technique with a pair of primers. such as TMJ arthritis, which can affect oral health related Primers COL1A1_F: 5ʹ-GCCTCCCAGAACATCACCTA to quality of life (OHRQoL) in adolescents.9 -3ʹ and COL1A1_R: 5ʹ-TGGGATGGAGGGAGTTTACA Nowadays, many studies found that polymorphism/ -3ʹ were used for COL1A1, both with a target of 456 bp. gene variation also can be the cause of malocclusion.10– Primers COL11A1_F: 5ʹ-TGTGTGCCTGTATTCCCAGA 12 Previous studies stated that the development of maloc- -3ʹ and COL11A1_R: 5ʹ-GAGGAC CCTGCATGAGAA-3ʹ clusion was affected by human evolution and some genetic were used for COL11A1, both with a target of 415 bp. GoTaq factors, including the muscle fibers plasticity and hetero- Green Master Mix (Promega) was utilized as PCR Mix. geneity of both jaw skeletal morphology and masticatory A total of 35 cycles of PCR (Thermocycler SensoQuest muscle, which can be inherited.13 GmbH) were performed, starting with Pre-Denaturation The existence of genetic variations in skeletal malocclu- (94°C) for 4 minutes, Denaturation (94°C) for 30 seconds, sion can be investigated through the detection of single Annealing (55°C) for 30 seconds, Extension (72°C) for nucleotide polymorphisms (SNPs). Therefore, this study 1 minute and Final Extension (72°C) for 7 minutes. raised the question of whether genetics can cause variations Positive results would be shown at the location of 456 bp in class II skeletal malocclusions in the Javanese ethnic for COL1A1 and 415 bp for COL11A1. 174 submit your manuscript | www.dovepress.com Clinical, Cosmetic and Investigational Dentistry 2020:12 DovePress Dovepress Ardani et al electrophoresis and amplified using PCR and 2% agarose electrophoresis, which led to the formation of a single band of
Load more

Recommended publications
  • Oral Diagnosis: the Clinician's Guide
    Wright An imprint of Elsevier Science Limited Robert Stevenson House, 1-3 Baxter's Place, Leith Walk, Edinburgh EH I 3AF First published :WOO Reprinted 2002. 238 7X69. fax: (+ 1) 215 238 2239, e-mail: [email protected]. You may also complete your request on-line via the Elsevier Science homepage (http://www.elsevier.com). by selecting'Customer Support' and then 'Obtaining Permissions·. British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library Library of Congress Cataloging in Publication Data A catalog record for this book is available from the Library of Congress ISBN 0 7236 1040 I _ your source for books. journals and multimedia in the health sciences www.elsevierhealth.com Composition by Scribe Design, Gillingham, Kent Printed and bound in China Contents Preface vii Acknowledgements ix 1 The challenge of diagnosis 1 2 The history 4 3 Examination 11 4 Diagnostic tests 33 5 Pain of dental origin 71 6 Pain of non-dental origin 99 7 Trauma 124 8 Infection 140 9 Cysts 160 10 Ulcers 185 11 White patches 210 12 Bumps, lumps and swellings 226 13 Oral changes in systemic disease 263 14 Oral consequences of medication 290 Index 299 Preface The foundation of any form of successful treatment is accurate diagnosis. Though scientifically based, dentistry is also an art. This is evident in the provision of operative dental care and also in the diagnosis of oral and dental diseases. While diagnostic skills will be developed and enhanced by experience, it is essential that every prospective dentist is taught how to develop a structured and comprehensive approach to oral diagnosis.
    [Show full text]
  • Tutankhamun's Dentition: the Pharaoh and His Teeth
    Brazilian Dental Journal (2015) 26(6): 701-704 ISSN 0103-6440 http://dx.doi.org/10.1590/0103-6440201300431 1Department of Oral and Maxillofacial Tutankhamun’s Dentition: Surgery, University Hospital of Leipzig, Leipzig, Germany The Pharaoh and his Teeth 2Institute of Egyptology/Egyptian Museum Georg Steindorff, University of Leipzig, Leipzig, Germany 3Department of Orthodontics, University Hospital of Greifswald, Greifswald, Germany Niels Christian Pausch1, Franziska Naether2, Karl Friedrich Krey3 Correspondence: Dr. Niels Christian Pausch, Liebigstraße 12, 04103 Leipzig, Germany. Tel: +49- 341-97-21160. e-mail: niels. [email protected] Tutankhamun was a Pharaoh of the 18th Dynasty (New Kingdom) in ancient Egypt. Medical and radiological investigations of his skull revealed details about the jaw and teeth status of the mummy. Regarding the jaw relation, a maxillary prognathism, a mandibular retrognathism and micrognathism have been discussed previously. A cephalometric analysis was performed using a lateral skull X-ray and a review of the literature regarding Key Words: Tutankhamun’s King Tutankhamun´s mummy. The results imply diagnosis of mandibular retrognathism. dentition, cephalometric analysis, Furthermore, third molar retention and an incomplete, single cleft palate are present. mandibular retrognathism Introduction also been discussed (11). In 1922, the British Egyptologist Howard Carter found the undisturbed mummy of King Tutankhamun. The Case Report spectacular discovery enabled scientists of the following In the evaluation of Tutankhamun’s dentition and jaw decades to analyze the Pharaoh's remains. The mummy alignment, contemporary face reconstructions and coeval underwent multiple autopsies. Until now, little was artistic images can be of further use. However, the ancient published about the jaw and dentition of the King.
    [Show full text]
  • Therapeutic Management of Patients with Class III Skeletal Malocclusion
    Szpyt Justyna, Gębska Magdalena. Therapeutic management of patients with class III skeletal malocclusion. Mandibular prognathism, maxillary retrognathism – a case report. Journal of Education, Health and Sport. 2019;9(5):20-31. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2656446 http://ojs.ukw.edu.pl/index.php/johs/article/view/6872 https://pbn.nauka.gov.pl/sedno-webapp/works/912455 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.04.2019. Revised: 25.04.2019. Accepted: 01.05.2019. Therapeutic management of patients with class III skeletal malocclusion. Mandibular prognathism, maxillary retrognathism – a case report Justyna Szpyt1, Magdalena Gębska2 1. Physiotherapy student, Faculty of Health Sciences, Pomeranian Medical University in Szczecin.
    [Show full text]
  • Pan Imaging News V3 I4
    Volume 4, Issue 4 US $6.00 Editor: Allan G. Farman, BDS, PhD (odont.), Assessing Growth and Development with Panoramic DSc (odont.), Diplomate of the Radiographs and Cephalometric Attachments: A critical American Board of Oral and Maxillofacial Radiology, Professor of tool for dental diagnosis and treatment planning Radiology and Imaging Sciences, Department of Surgical and Hospital By Dr. Allan G. Farman Dentistry, The University of It is recommended that radio- indicator of age is that the three Louisville School of Dentistry, graphs be made periodically including permanent molar teeth in each quad- Louisville, KY. both during the mixed dentition (8-9 rant erupt approximately at six-year year old) and adolescence (12-14 year intervals. The first permanent molar Featured Article: old) to evaluate growth and develop- erupts around 6 years, the second Assessing Growth and Development ment, and to look for asymptomatic permanent molar around 12 years, and with Panoramic Radiographs and dental disease [1-3]. Substantial the third molars around 18 years. Root Cephalometric Attachments: A critical differences in the assessed biological formation for permanent teeth is tool for dental diagnosis and and the known chronological age can completed roughly three years following treatment planning be indicators of a variety of inherited eruption. The first major attempt at and congenital conditions. Further, local developing a chronology for human In The Recent Literature: failure in dental eruption within the tooth development was that of Logan normal time range can be evidence of and Kronfeld (1933) and with minor Implantology dental impaction and possibly of a modification is still usable as a rough pathological process such as a hamar- and ready guide.
    [Show full text]
  • Diseases of the Digestive System (KOO-K93)
    CHAPTER XI Diseases of the digestive system (KOO-K93) Diseases of oral cavity, salivary glands and jaws (KOO-K14) lijell Diseases of pulp and periapical tissues 1m Dentofacial anomalies [including malocclusion] Excludes: hemifacial atrophy or hypertrophy (Q67.4) K07 .0 Major anomalies of jaw size Hyperplasia, hypoplasia: • mandibular • maxillary Macrognathism (mandibular)(maxillary) Micrognathism (mandibular)( maxillary) Excludes: acromegaly (E22.0) Robin's syndrome (087.07) K07 .1 Anomalies of jaw-cranial base relationship Asymmetry of jaw Prognathism (mandibular)( maxillary) Retrognathism (mandibular)(maxillary) K07.2 Anomalies of dental arch relationship Cross bite (anterior)(posterior) Dis to-occlusion Mesio-occlusion Midline deviation of dental arch Openbite (anterior )(posterior) Overbite (excessive): • deep • horizontal • vertical Overjet Posterior lingual occlusion of mandibular teeth 289 ICO-N A K07.3 Anomalies of tooth position Crowding Diastema Displacement of tooth or teeth Rotation Spacing, abnormal Transposition Impacted or embedded teeth with abnormal position of such teeth or adjacent teeth K07.4 Malocclusion, unspecified K07.5 Dentofacial functional abnormalities Abnormal jaw closure Malocclusion due to: • abnormal swallowing • mouth breathing • tongue, lip or finger habits K07.6 Temporomandibular joint disorders Costen's complex or syndrome Derangement of temporomandibular joint Snapping jaw Temporomandibular joint-pain-dysfunction syndrome Excludes: current temporomandibular joint: • dislocation (S03.0) • strain (S03.4) K07.8 Other dentofacial anomalies K07.9 Dentofacial anomaly, unspecified 1m Stomatitis and related lesions K12.0 Recurrent oral aphthae Aphthous stomatitis (major)(minor) Bednar's aphthae Periadenitis mucosa necrotica recurrens Recurrent aphthous ulcer Stomatitis herpetiformis 290 DISEASES OF THE DIGESTIVE SYSTEM Diseases of oesophagus, stomach and duodenum (K20-K31) Ill Oesophagitis Abscess of oesophagus Oesophagitis: • NOS • chemical • peptic Use additional external cause code (Chapter XX), if desired, to identify cause.
    [Show full text]
  • The National Dental Practice-Based Research Network Adult Anterior
    ORIGINAL ARTICLE The National Dental Practice-Based Research Network Adult Anterior Open Bite Study: Treatment recommendations and their association with patient and practitioner characteristics Greg Huang,a Camille Baltuck,b Ellen Funkhouser,c Hsuan-Fang (Cathy) Wang,a,d Lauren Todoki,a Sam Finkleman,a Peter Shapiro,a Roozbah Khosravi,a Hsiu-Ching (Joanna) Ko,a Geoffrey Greenlee,a Jaime De Jesus-Vinas,e Michael Vermette,f Matthew Larson,g Calogero Dolce,h Chung How Kau,i and David Harnick,j and the National Dental Practice-Based Research Network Collaborative Groupk Seattle, Wash, Portland, Ore, Birmingham, Ala, Taipei, Taiwan, San Juan, PR, Concord, NH, Eau Claire, Wis, Gainesville, Fla, and Albuquerque, NM Introduction: This aim of this paper is to describe and identify the practitioner and patient characteristics that are associated with treatment recommendations for adult anterior open bite patients across the United States. Methods: Practitioners and patients were recruited within the framework of the National Dental Practice-Based Research Network. Practitioners were asked about their demographic characteristics and their treatment recommendations for these patients. The practitioners also reported on their patients' dentofacial characteristics and provided initial cephalometric scans and intraoral photographs. Patients were asked about their demographic characteristics, previous orthodontic treatment, and goals for treatment. Four main treatment groups were evaluated: aligners, fixed appliances, temporary anchorage devices (TADs), and orthognathic surgery. Extractions were also investigated. Predictive multivariable models were created comparing various categories of treatment as well as extraction/nonextraction decisions. Results: Ninety-one practitioners (mostly orthodontists) and 347 patients were recruited from October 2015 to December 2016. Increased aligner recommendations were associated with white and Asian patients, the presence of tongue habits, and female practitioners.
    [Show full text]
  • Abstracts from the 51St European Society of Human Genetics Conference: Electronic Posters
    European Journal of Human Genetics (2019) 27:870–1041 https://doi.org/10.1038/s41431-019-0408-3 MEETING ABSTRACTS Abstracts from the 51st European Society of Human Genetics Conference: Electronic Posters © European Society of Human Genetics 2019 June 16–19, 2018, Fiera Milano Congressi, Milan Italy Sponsorship: Publication of this supplement was sponsored by the European Society of Human Genetics. All content was reviewed and approved by the ESHG Scientific Programme Committee, which held full responsibility for the abstract selections. Disclosure Information: In order to help readers form their own judgments of potential bias in published abstracts, authors are asked to declare any competing financial interests. Contributions of up to EUR 10 000.- (Ten thousand Euros, or equivalent value in kind) per year per company are considered "Modest". Contributions above EUR 10 000.- per year are considered "Significant". 1234567890();,: 1234567890();,: E-P01 Reproductive Genetics/Prenatal Genetics then compared this data to de novo cases where research based PO studies were completed (N=57) in NY. E-P01.01 Results: MFSIQ (66.4) for familial deletions was Parent of origin in familial 22q11.2 deletions impacts full statistically lower (p = .01) than for de novo deletions scale intelligence quotient scores (N=399, MFSIQ=76.2). MFSIQ for children with mater- nally inherited deletions (63.7) was statistically lower D. E. McGinn1,2, M. Unolt3,4, T. B. Crowley1, B. S. Emanuel1,5, (p = .03) than for paternally inherited deletions (72.0). As E. H. Zackai1,5, E. Moss1, B. Morrow6, B. Nowakowska7,J. compared with the NY cohort where the MFSIQ for Vermeesch8, A.
    [Show full text]
  • Granular Cell Tumour of the Tongue in a 17Yearold Orthodontic Patient: A
    bs_bs_banner Oral Surgery ISSN 1752-2471 CASE REPORT Granular cell tumour of the tongue in a 17-year-old orthodontic patient: a case report P.Hita-Davis1, P.Edwards2, S. Conley3 & T.J.Dyer4 1Oral Maxillofacial Surgery, School of Dentistry, Ann Arbor, MI, USA 2Department of Oral Pathology,Medicine and Radiology, Indiana University, Indianapolis, IN, USA 3Department of Orthodontics and Pediatric Dentistry, University of Michigan, Ann Arbor, MI, USA 4Oral Surgery, Boston University, Boston, MA, USA Key words: Abstract cyst, diagnosis, examination To describe the clinical presentation of a granular cell tumour (GCT) in an Correspondence to: orthodontic patient, as well as discuss its aetiology and treatment of Dr P Hita-Davis choice. We present a case of GCT of the tongue in an otherwise healthy Oral Maxillofacial Surgery 17-year-old male patient along with a brief review of literature on GCTs. School of Dentistry The lesion was surgically excised and orthodontic treatment was success- 1011 N. University Avenue Ann Arbor, MI 48109 fully finalised. Clinically, GCTs are indistinguishable from other benign USA connective tissue and neural tissue neoplasms and may be found in any Tel.:+1 734 764 1542 site, with cases commonly involving the gastrointestinal system, breast Fax: +1 734 615 8399 and lung. However, over 50% of cases involve the head and neck, with email: [email protected] the tongue being the most frequently involved site (65–85% of oral GCTs). GCTs demonstrate a close anatomical relationship with peripheral Accepted: 6 June 2013 nerve fibres and demonstrate the presence of myelin and axon-like doi:10.1111/ors.12055 structures thus lending credence to their neural origin.
    [Show full text]
  • Common Icd-10 Dental Codes
    COMMON ICD-10 DENTAL CODES SERVICE PROVIDERS SHOULD BE AWARE THAT AN ICD-10 CODE IS A DIAGNOSTIC CODE. i.e. A CODE GIVING THE REASON FOR A PROCEDURE; SO THERE MIGHT BE MORE THAN ONE ICD-10 CODE FOR A PARTICULAR PROCEDURE CODE AND THE SERVICE PROVIDER NEEDS TO SELECT WHICHEVER IS THE MOST APPROPRIATE. ICD10 Code ICD-10 DESCRIPTOR FROM WHO (complete) OWN REFERENCE / INTERPRETATION/ CIRCUM- STANCES IN WHICH THESE ICD-10 CODES MAY BE USED TIP:If you are viewing this electronically, in order to locate any word in the document, click CONTROL-F and type in word you are looking for. K00 Disorders of tooth development and eruption Not a valid code. Heading only. K00.0 Anodontia Congenitally missing teeth - complete or partial K00.1 Supernumerary teeth Mesiodens K00.2 Abnormalities of tooth size and form Macr/micro-dontia, dens in dente, cocrescence,fusion, gemination, peg K00.3 Mottled teeth Fluorosis K00.4 Disturbances in tooth formation Enamel hypoplasia, dilaceration, Turner K00.5 Hereditary disturbances in tooth structure, not elsewhere classified Amylo/dentino-genisis imperfecta K00.6 Disturbances in tooth eruption Natal/neonatal teeth, retained deciduous tooth, premature, late K00.7 Teething syndrome Teething K00.8 Other disorders of tooth development Colour changes due to blood incompatability, biliary, porphyria, tetyracycline K00.9 Disorders of tooth development, unspecified K01 Embedded and impacted teeth Not a valid code. Heading only. K01.0 Embedded teeth Distinguish from impacted tooth K01.1 Impacted teeth Impacted tooth (in contact with another tooth) K02 Dental caries Not a valid code. Heading only.
    [Show full text]
  • Dental Health Following Cancer Treatment
    Survivorship Clinic Dental health following cancer treatment Treatment for cancer often increases the risk for dental problems. As a cancer survivor, it is important for you to understand the reasons why dental care is especially important for maintaining your health. What are the risk factors for dental problems after cancer treatment? Treatment with chemotherapy before your permanent teeth were fully formed. Radiation that included the mouth and/or salivary glands, such as the following: Cranial (whole brain) Craniospinal Nasopharyngeal (nose and throat) Oropharyngeal (mouth and throat) Orbital Eye Ear Infratemporal (midfacial area behind the cheekbones) Cervical (neck) Cervical spine (spine in the neck area) Mantle (neck and chest areas) Total body irradiation (TBI) What dental problems can occur following treatment for cancer? Problems that may be a result of chemotherapy include: Increased risk for cavities Shortening or thinning of the roots of the teeth Absence of teeth or roots Problems with development of tooth enamel resulting in white or discolored patches on the teeth, grooves and pits in the teeth, and/or Easy staining of the teeth Because teeth develop slowly, these problems are more likely to develop in people who received chemotherapy over a prolonged period (several years). Fred Hutchinson Cancer Research Center Survivorship Program Survivorship Clinic Problems that may be a result of radiation to the mouth and/or salivary glands include: Increased risk for cavities Shortening or thinning of the roots
    [Show full text]
  • Congenital Hypothyrodism and Its Oral Manifestations Hipotiroidismo Congénito Y Sus Manifestaciones Bucales
    www.medigraphic.org.mx Revista Odontológica Mexicana Facultad de Odontología Vol. 18, No. 2 April-June 2014 pp 133-138 CASE REPORT Congenital hypothyrodism and its oral manifestations Hipotiroidismo congénito y sus manifestaciones bucales Marxy E Reynoso Rodríguez,* María A Monter García,§ Ignacio Sánchez FloresII ABSTRACT RESUMEN Hypothyroidism is one of the most common thyroid disorders. El hipotiroidismo es el más común de los trastornos de la tiroides, Hypothyroidism can be congenital in cases when the thyroid puede ser congénito si la glándula tiroides no se desarrolla correc- gland does not develop normally. Female predominance is a tamente (hipotiroidismo congénito). La predominancia femenina es characteristic of congenital hypothyroidism. Dental characteristics una característica. Entre las características odontológicas del hi- of hypothyroidism are thick lips, a large-sized tongue which, due potiroidismo se observan labios gruesos, lengua de gran tamaño, to its position, can elicit anterior open bite as well as fanned-out que debido a su posición suele producir mordida abierta anterior y anterior teeth. In these cases, delayed eruption of primary and dientes anteriores en abanico, destaca que la dentición temporal y permanent dentitions can be observed, and teeth, even though permanente presentan un retardo eruptivo característico y, aunque normal-sized, are crowded due to the small-sized jaws. This study los dientes son de tamaño normal, suelen estar apiñados por el ta- presents clinical cases of female patients diagnosed with congenital maño pequeño de los maxilares. Se presentan dos casos clínicos hypothyroidism who sought treatment at the Dental Pediatrics Unit de pacientes de sexo femenino que acuden a la clínica de Especia- of the Autonomous University of the State of Mexico.
    [Show full text]
  • Description Concept ID Synonyms Definition
    Description Concept ID Synonyms Definition Category ABNORMALITIES OF TEETH 426390 Subcategory Cementum Defect 399115 Cementum aplasia 346218 Absence or paucity of cellular cementum (seen in hypophosphatasia) Cementum hypoplasia 180000 Hypocementosis Disturbance in structure of cementum, often seen in Juvenile periodontitis Florid cemento-osseous dysplasia 958771 Familial multiple cementoma; Florid osseous dysplasia Diffuse, multifocal cementosseous dysplasia Hypercementosis (Cementation 901056 Cementation hyperplasia; Cementosis; Cementum An idiopathic, non-neoplastic condition characterized by the excessive hyperplasia) hyperplasia buildup of normal cementum (calcified tissue) on the roots of one or more teeth Hypophosphatasia 976620 Hypophosphatasia mild; Phosphoethanol-aminuria Cementum defect; Autosomal recessive hereditary disease characterized by deficiency of alkaline phosphatase Odontohypophosphatasia 976622 Hypophosphatasia in which dental findings are the predominant manifestations of the disease Pulp sclerosis 179199 Dentin sclerosis Dentinal reaction to aging OR mild irritation Subcategory Dentin Defect 515523 Dentinogenesis imperfecta (Shell Teeth) 856459 Dentin, Hereditary Opalescent; Shell Teeth Dentin Defect; Autosomal dominant genetic disorder of tooth development Dentinogenesis Imperfecta - Shield I 977473 Dentin, Hereditary Opalescent; Shell Teeth Dentin Defect; Autosomal dominant genetic disorder of tooth development Dentinogenesis Imperfecta - Shield II 976722 Dentin, Hereditary Opalescent; Shell Teeth Dentin Defect;
    [Show full text]