Product Datasheet

DOCK11 Antibody

Catalog No: #47074

Orders: [email protected] Description Support: [email protected]

Product Name DOCK11 Antibody

Host Species Rabbit

Clonality Polyclonal

Purification Antigen affinity purification

Applications IHC

Species Reactivity Hu

Specificity The antibody detects endogenous levels of total DOCK11 .

Immunogen Type peptide

Immunogen Description Synthetic peptide of human DOCK11

Target Name DOCK11

Other Names ACG; ZIZ2; bB128O4.1

Accession No. Swiss-Prot#:Q5JSL3 NCBI ID:139818Gene Accssion:NP_653259

Concentration 1.3mg/ml

Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage Store at -20C

Application Details

Immunofluorescence:1: 20-100

Images

The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 47074(DOCK11 Antibody) at dilution 1/35. (Original magnification: ?00)

Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 1 The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 47074(DOCK11 Antibody) at dilution 1/35. (Original magnification: ?00)

Background

Small GTPases of the Rho family, Rho, Rac, and Cdc42, are critical regulators of the actin cytoskeleton and many other cellular processes. Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine exchange factors (GEFs). DOCK 11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073 amino acid protein belonging to the DOCK family of cytokinesis-regulating that is mainly expressed in peripheral blood leukocytes. DOCK 11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP. Cdc42 mediates cell polarity, , progression and cellCcell contacts. Similar to other DOCK family members, DOCK 11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.

Note: This product is for in vitro research use only and is not intended for use in humans or animals.

Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 2