DOCK11 Antibody

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Product Datasheet DOCK11 Antibody Catalog No: #47074 Orders: [email protected] Description Support: [email protected] Product Name DOCK11 Antibody Host Species Rabbit Clonality Polyclonal Purification Antigen affinity purification Applications IHC Species Reactivity Hu Specificity The antibody detects endogenous levels of total DOCK11 protein. Immunogen Type peptide Immunogen Description Synthetic peptide of human DOCK11 Target Name DOCK11 Other Names ACG; ZIZ2; bB128O4.1 Accession No. Swiss-Prot#:Q5JSL3 NCBI Gene ID:139818Gene Accssion:NP_653259 Concentration 1.3mg/ml Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage Store at -20C Application Details Immunofluorescence:1: 20-100 Images The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 47074(DOCK11 Antibody) at dilution 1/35. (Original magnification: ?00) Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 1 The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 47074(DOCK11 Antibody) at dilution 1/35. (Original magnification: ?00) Background Small GTPases of the Rho family, Rho, Rac, and Cdc42, are critical regulators of the actin cytoskeleton and many other cellular processes. Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine nucleotide exchange factors (GEFs). DOCK 11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins that is mainly expressed in peripheral blood leukocytes. DOCK 11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP. Cdc42 mediates cell polarity, gene expression, cell cycle progression and cellCcell contacts. Similar to other DOCK family members, DOCK 11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2. Note: This product is for in vitro research use only and is not intended for use in humans or animals. Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 2.

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