Value-Based Contracts: 2009 – Q1 2018

VALUE-BASED CONTRACTS: 2009 – Q1 2018 This list includes value-based contracts (VBCs) executed and publicly announced in the United States from 2009 through the first quarter of 2018. This list is not comprehensive; many VBCs are executed without the release of publicly available information.

This list is current as of April 5, 2018.

Brand Non-Proprietary Therapeutic Biopharmaceutical Year Disease Area Payer Name Name Area Company

Extampza Collegium 1 Oxycodone 2018 Opioids Pain management Cigna ER Pharmaceutical

Boehringer Prime 2 Jardiance Empagliflozin 2018 Endocrinology Diabetes Ingelheim Therapeutics

Voretigene Harvard Pilgrim 3 Luxturna 2018 Opthalmology Retinal Disease Spark Therapeutics Neparvovec-rzyl Health Care

4 Victoza Liraglutide 2018 Endocrinology Diabetes Novo Nordisk SelectHealth

Cardiovascular Cardiovascular Harvard Pilgrim 5 Brilinta Ticagrelor 2017 AstraZeneca Disease Disease Health Care

Harvard Pilgrim 6 Bydureon Exenatide 2017 Endocrinology Diabetes AstraZeneca Health Care

Harvard Pilgrim 7 Enbrel Etanercept 2017 Rheumatology Rheumatoid Arthritis Amgen Health Care

Harvard Pilgrim 8 Forteo Teriparatide 2017 Musculoskeletal Osteoporosis Eli Lilly Health Care

Janumet/ 9 Sitagliptin/Metformin 2017 Endocrinology Diabetes Merck Aetna Januvia

Acute Lymphoblastic 10 Kymriah Tisagenlecleucel 2017 Oncology Novartis Unspecified Leukemia

Unspecified 11 Unspecified (MS) 2017 Neurology Multiple Sclerosis Biogen SelectHealth (MS)

Unspecified 12 Unspecified (MS) 2017 Neurology Multiple Sclerosis Biogen Harvard Pilgrim (MS)

Unspecified 13 Unspecified (MS) 2017 Neurology Multiple Sclerosis Biogen Moda Health (MS)

Unspecified 14 Unspecified (MS) 2017 Neurology Multiple Sclerosis Biogen Abarca Health (MS)

15 Victoza Liraglutide 2017 Endocrinology Diabetes Novo Nordisk Humana

Cardiovascular 16 Effient Prasugrel 2016 Cardiology Eli Lilly Humana Disease

Sacubitril and 17 Entresto 2016 Cardiology Heart Failure Novartis Cigna Valsartan

Sacubitril and 18 Entresto 2016 Cardiology Heart Failure Novartis Aetna full Valsartan color Sacubitril and Harvard Pilgrim 19 Entresto 2016 Cardiology Heart Failure Novartis Valsartan Health Care black

w hite

1 www.phrma.org/value-collaborative VALUE-BASED CONTRACTS: 2009 – Q1 2018 This list includes value-based contracts (VBCs) executed and publicly announced in the United States from 2009 through the first quarter of 2018. This list is not comprehensive; many VBCs are executed without the release of publicly available information.

This list is current as of April 5, 2018.

20 Praluent Alirocumab 2016 Cardiology Hypercholesterolemia Sanofi, Regeneron Cigna

21 Repatha Evolocumab 2016 Cardiology Hypercholesterolemia Amgen Cigna

Harvard Pilgrim 22 Trulicity Dulaglutide 2016 Endocrinology Diabetes Eli Lilly Health Care

Non–small-cell Lung 23 Avastin Bevacizumab 2015 Oncology Genentech Priority Health Cancer (NSCLC)

University of Cardiovascular Cardiovascular 24 Brilinta Ticagrelor 2015 AstraZeneca Pittsburgh Disease Disease Medical Center

Infectious 25 Harvoni Ledipasvir-sofosbuvir 2015 Hepatitis C Gilead Cigna Diseases

Infectious 26 Harvoni Ledipasvir-sofosbuvir 2015 Hepatitis C Gilead Optum Diseases

27 Iressa Gefitinib 2015 Oncology Lung Cancer AstraZeneca Express Scripts

Familial Prime 28 Praluent Alirocumab 2015 Endocrinology Sanofi, Regeneron Hypercholesterolemia Therapeutics

Familial Harvard Pilgrim 29 Repatha Evolocumab 2015 Endocrinology Amgen Hypercholesterolemia Health Care

Familial Prime 30 Repatha Evolocumab 2015 Endocrinology Amgen Hypercholesterolemia Therapeutics

31 Repatha Evolocumab 2015 Cardiology Hypercholesterolemia Amgen CVS Health

Dasabuvir, Ombitasvir, Infectious 32 Viekira Pak Paritaprevir, 2015 Hepatitis C AbbVie Express Scripts Diseases and Ritonavir

Multiple Prime 33 Rebif Interferon Beta-1a 2012 Neurology EMD Serono Sclerosis Therapeutics

Prime 34 Actonel Risedronate 2011 Endocrinology Osteoporosis Warner Chilcott Therapeutics

Health Alliance Bayer HealthCare 35 Betaseron Interferon Beta-1b 2011 Neurology Multiple Sclerosis Medical Plans, Pharmaceuticals Inc.

Prime 36 Januvia Sitagliptin 2011 Endocrinology Diabetes Merck Therapeutics

37 Rebif Interferon Beta-1a 2011 Neurology Multiple Sclerosis EMD Serono Cigna

38 Actonel Risedronate 2009 Endocrinology Osteoporosis Proctor and Gamble Health Alliance full color Janumet/ 39 Metformin/Sitagliptin 2009 Endocrinology Diabetes Merck Cigna Januvia

black

w hite

2 www.phrma.org/value-collaborative