NPM1 Mutations Occur Rarely Or Not at All in Chronic Myeloid Leukaemia Patients in Chronic Phase Or Blast Crisis

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NPM1 mutations occur rarely or not at all in chronic myeloid leukaemia patients in chronic phase or blast crisis Leukemia (2013) 27, 489–490; doi:10.1038/leu.2012.193 Progression of chronic phase-chronic myeloid leukaemia (CP-CML) to accelerated phase and blast crisis (BC) is frequently associated 3 Patel JP, Gonen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J et al. Prognostic relevance of integrated genetic proﬁling in acute myeloid leukemia. N Engl J Med 2012; 366: 1079–1089. 4 Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 2005; 352: 254–266. 5 Georgiou G, Efthymiou A, Vardounioti I, Boutsikas G, Angelopoulou MK, Vassila- kopoulos TP et al. Development of acute myeloid leukemia with NPM1 mutation,.

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