NPM1 Mutations Occur Rarely Or Not at All in Chronic Myeloid Leukaemia Patients in Chronic Phase Or Blast Crisis

NPM1 Mutations Occur Rarely Or Not at All in Chronic Myeloid Leukaemia Patients in Chronic Phase Or Blast Crisis

NPM1 mutations occur rarely or not at all in chronic myeloid leukaemia patients in chronic phase or blast crisis Leukemia (2013) 27, 489–490; doi:10.1038/leu.2012.193 Progression of chronic phase-chronic myeloid leukaemia (CP-CML) to accelerated phase and blast crisis (BC) is frequently associated 3 Patel JP, Gonen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 2012; 366: 1079–1089. 4 Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 2005; 352: 254–266. 5 Georgiou G, Efthymiou A, Vardounioti I, Boutsikas G, Angelopoulou MK, Vassila- kopoulos TP et al. Development of acute myeloid leukemia with NPM1 mutation,.

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