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United States Patent Office Patented Jan 3,555,103 United States Patent Office Patented Jan. 12, 1971 2 3,555,103 ter yield with the formation of a smaller number of by PREPARATHON OF CYMENES products, and the fraction of the by-products which may Max Strohmeyer, Ludwigshafen (Rhine), Germany, as be used again in the reaction is higher. In the produc signor to Badische Anilin- & Soda-Fabrik Aktienge tion of p-cymene, far smaller amounts of thr difficultly sellschaft, Ludwigshafen (Rhine), Germany separable o-isomer are obtained. No Drawing. Filed July 16, 1968, Ser. No. 745,093 5 Methyldiisopropylbenzenes, preferably the 1,3,5- and Claims priority, application Germany, July 19, 1967, 1,2,4-methyldiisopropylbenzene, and toluene or mixtures 1,643,629 thereof are used as the starting materials. The aforemen Int. CI. C07c3/58, 5/22 tioned mixtures preferably contain a substance which can U.S. C. 260-672 15 Claims react in the transalkylation stage with toluene to form IO cymenes, for example triisopropylbenzene. The reaction mixture which is obtained at the end of the reaction after ABSTRACT OF THE DISCLOSURE the alkylation stage is advantageously recycled after sepa Process for the preparation of cymenes by reaction of ration of the cymenes, and is used together with fresh methyldiisopropylbenzenes with toluene and propylene in 5 starting materials as the starting mixture. If interest is two or three stages. The products of the new process centered on one specific end product only, for example are valuable starting materials for the production of plas p-cymene, any isomers formed in the reaction may be re tics materials or fibers. cycled to the starting mixture or may advantageously be added to the isomerization stage. The process is carried out in three stages: in the first stage, the transalkylation stage, methyldiisopropylben This invention relates to the production of cymenes Zenes are reacted with toluene, if desired in the form by the reaction of methyldiisopropylbenzenes with toluene of the aforementioned mixtures, in a molar ratio of total and propylene in two or three stages. benzene rings to total isopropyl groups between 1:0.75 From the Journal of the American Chemical Society, 25 and 1:0.95. Generally, only unreacted starting materials volume 49 (1927), page 3142 et seq., it is known to al are obtained in addition to cymenes, preferably m- and kylate toluene with olefins, for example, propylene, in p-cymene. the presence of Friedel-Crafts catalysts, mixtures of a In the subsequent isomerization stage, the transalkyla large number of components being formed which are diffi tion is continued and the undesired cymene isomers are cult to separate. Such components may be for exam 30 preferably isomerized; as a rule only isopropyl groups, ple: benzene, toluene, o-xylene, m-xylene, p-xylene, o and not methyl groups, are split off. Thus for example, cymene, m-cymene, p-cymene, cumene, all isomeric diiso in the production of p-cymene, the m- and o-cymenes propylbenzenes, methyldiisopropylbenzenes, dimethyliso obtained after the alkylation stage may be recycled to propylbenzenes, trimethylbenzenes, triisopropylbenzenes, the isomerization stage. Without the addition of cymene, benzenes substituted four or more times by methyl and/or 3. 5 a molar ratio of total benzene rings to total isopropyl isopropyl radicals, or decomposition products. groups of between 1:0.75 and 1:0.95 is maintained in the However, a process can only be used on a large scale if isomerization stage, and with the addition of cymene a it permits the yield of cymenes to be increased, the num molar ratio of between 1:08 and 1:1. If no cymene isom ber of by-products to be diminished, and as much of the erization is necessary or desired, the reaction mixture, by-products obtained as possible to be recycled to the re 40 if desired after prolonged reaction time in the transalkyl action. It is known (Houben-Weyl, Methoden der organ ation stage, may be transferred from this stage directly ischen Chemie, volume 4/2 (1955), page 95) that the to the alkylation stage. Increased amounts of cymenes, content of a desired component in such mixtures may be especially the desired cymene isomers, and smaller increased by transalkylation. Since isopropyl and methyl amounts of the starting materials are obtained as prod groups are split off in such transalkylations and partici ucts of the isomerization stage, without any substantial pate in the alkylation, the content of undesired xylenes increase in the dimethyl compounds. and dimethylisopropylbenzenes in the mixture is also in In the third stage, the alkylation stage, the reaction creased. mixture of the isomerization stage is reacted with tolu It is an object of this invention is to provide a new ene and propylene, a molar ratio of total benzene rings to process for the production of cymenes in good yield and total C of between 1:0.2 and 1:0.8 being maintained. with the formation of a smaller number of by-products The reaction is stopped when a molar ratio of total ben than in prior art processes, the fraction of the by-products zene rings to total isopropyl groups 1:0.8, preferably which may be used again in the reaction being higher. 1:0.4, has been attained. A further object of this invention is to provide a new Aluminum chloride and hydrogen chloride are used process for the production of p-cymene with the simul as catalyst in the reaction, advantageously in a molar taneous formation of far smaller amounts of the difficultly ratio of 1:1. In general, 0.3 to 5, preferably 0.5 to 2% separable ortho-isomer than in prior art processes. by weight of aluminum chloride, with reference to the These and other objects of the invention are achieved total weight of hydrocarbons, is added to the transalkyl and cymenes are obtained in an advantageous manner ation stage. It appears that aromatic complex compounds by reacting methyldiisopropylbenzenes with toluene in the 60 of aluminum chloride are formed in the transalkylation molar ratio 1:1 in a transalkylation stage in the presence stage, which promote the isomerization or alkylation in of aluminum chloride and hydrogen chloride, if desired the two following stages and decrease the formation of isomerizing the reaction mixture formed in a subsequent o-cymene and dimethyl compounds in favor of m-cymene isomerization stage, and reacting the resultant reaction and p-cymene. Accordingly, in general no further amounts mixture, together with toluene, in an alkylation stage of catalyst are added to these stages. If however additional with propylene, a molar ratio of total benzene rings to amounts of cymene are added to the isomerization stage total C between 1:0.75 and 1:0.95 being maintained in in the afore-mentioned way, a further addition of pref the transalkylation stage and between 1:0.2 and 1:0.8 erably 3 to 5% by weight of aluminum chloride, with being maintained in the alkylation stage. reference to the amount by weight of added cymene, As compared with the aforementioned processes, the O and the corresponding amount of hydrogen chloride is process according to this invention yields cymenes in bet advantageous. These additional amounts may also form 3,555,103 3. 4 the afore-mentioned complex compounds, which promote second stirred vessel (349 parts per hour), has the fol the subsequent alkylation. lowing composition: The reaction is advantageously carried out in the trans Percent alkylation and isomerization stages at a temperature be Benzene ----------------------------------- 0. tween 20 and 75° C. and in the alkylation stage at a Toluene ----------------------------------- 17.0 temperature between 20 and 110° C., preferably be 5 Xylenes ----------------------------------- 1.3 tween 20 and 75 C. It may be carried out at atmospher m-Cymene --------------------------------- 42.1 ic pressure or superatmospheric pressure, and continu p-Cymene --------------------------------- 17.2 ously or batch-wise. oCymene ---------------------------------- 1.1 The reaction may be carried out as follows. A mixture O Dimethylisopropylbenzenes ------------------- 1.3 of methyldiisopropylbenzene, toluene, aluminum chloride Methyldiisopropylbenzenes ------------------- 20.2 and hydrochloric acid is reacted in a transalkylation stage at the afore-mentioned temperature and in the This corresponds to a ratio of total benzene rings to afore-mentioned relative proportions for 1 to 3 hours total of isopropyl groups of 1:0.91. In this stage, too, while mixing thoroughly. The reaction mixture formed there is no increase in the amount of by-products. is isomerized, if desired with the addition of cymene iso The reaction mixture from vessel (2), which still con mers and further amounts of catalyst, in the afore-men tains about 3% by weight (with reference to the hydro tioned manner for a residence time of 0.3 to 1.5 hours. carbons) of emulsified catalyst complex compound, is The reaction mixture of the isomerization stage is then reacted in a third stirred vessel at 75° C. while stirring reacted in a further alkylation stage with toluene and vigorously with 520 parts of toluene and 39 parts of pro propylene in the afore-mentioned relative proportions pylene per hour. and at the afore-mentioned temperature for a residence Water is added to the mixture (908 parts per hour) time of 0.5 to 30 minutes. The molar ratio of total benzene which continously leaves the vessel, and the organic phase rings to total C is advantageously determined by gas chro formed is separated from the aqueous phase and frac matography in the three stages, and suitably adjusted. tionally distilled. 892 parts are obtained from the stirred The mixture leaving the alkylation stage may be Sep vessel (3), having the composition: arated from the catalyst, which may be used again for Percent the propylation, or water is added to the mixture, which Benzene ----------------------------------- 0.15 is preferable.
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