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Effective July 2008

COMMUNICABLE AND OTHER INFECTIOUS DISEASES REPORTABLE IN MASSACHUSETTS BY HEALTHCARE PROVIDERS* *The list of reportable diseases is not limited to those designated below and includes only those which are primarily reportable by clinical providers.

A full list of reportable diseases in Massachusetts is detailed in 105 CMR 300.100.

REPORT IMMEDIATELY BY PHONE! This includes both suspect and confirmed cases. All cases should be reported to your local board of health; if unavailable, call the Massachusetts Department of Public Health: Telephone: (617) 983-6800 Confidential Fax: (617) 983-6813 • REPORT PROMPTLY (WITHIN 1-2 BUSINESS DAYS). This includes both suspect and confirmed cases. All cases should be reported to your local board of health; if unavailable, call the Massachusetts Department of Public Health: Telephone: (617) 983-6800 Confidential Fax: (617) 983-6813

• • Anthrax • Any case of an unusual illness thought to have Measles public health implications • Any cluster/outbreak of illness, including but not Meningitis, bacterial, community acquired limited to foodborne illness • Meningitis, viral (aseptic), and other infectious Botulism (non-bacterial) , invasive • Chagas disease () • Creutzfeldt-Jakob disease (CJD) and variant CJD Monkeypox or other orthopox virus Diphtheria • Mumps • • Pertussis • Encephalitis, any cause • Food poisoning and toxicity (includes poisoning Polio Animal bites should be by ciguatera, scombrotoxin, mushroom toxin, • Psittacosis reported immediately tetrodotoxin, paralytic shellfish and amnesic • to the designated local shellfish) Rabies in humans authority. • • Reye syndrome Group A , invasive Rheumatic fever influenzae, invasive • Rickettsialpox • Hansen’s disease () • Rocky Mountain Hantavirus Rubella Hemolytic uremic syndrome Severe acute respiratory syndrome (SARS) Hepatitis A (IgM+ only) Smallpox • HBsAg+ pregnant women Tetanus Influenza, pediatric deaths (<18 years) • Toxic shock syndrome Isolates should Infection due to influenza A viruses that are different • Trichinosis be submitted to from currently circulating human influenza A H1 and Hinton State human influenza A H3 viruses, including those Laboratory Institute. subtyped as non-human in origin and those that • Varicella () cannot be subtyped with standard methods and Viral hemorrhagic fevers reagents

Important Note: MDPH, its authorized agents, and local boards of health have the authority to collect pertinent information on all reportable diseases, including those not listed on this page, as part of epidemiological investigations (M.G.L. c. 111, s. 7).

105 CMR 300.000 Reportable Diseases, Surveillance, and Isolation and Quarantine Requirements, 2nd Edition, August 2009, Page 1 of 2 Effective July 2008

COMMUNICABLE AND OTHER INFECTIOUS DISEASES REPORTABLE IN MASSACHUSETTS BY HEALTHCARE PROVIDERS* *The list of reportable diseases is not limited to those designated below and includes only those which are primarily reportable by clinical providers.

A full list of reportable diseases in Massachusetts is detailed in 105 CMR 300.100.

Report Directly to the Massachusetts Department of Public Health, Bureau of Communicable Disease Control 305 South Street, Jamaica Plain, MA 02130

• HIV infection and AIDS (617) 983-6560

• Sexually Transmitted Diseases (617) 983-6940 Isolates Ophthalmia neonatorum: should be Chlamydial infections (genital) a. Gonoccocal Genital warts b. Other agents submitted to Pelvic inflammatory disease Hinton State Gonorrhea, resistant to fluoroquinolones or a. Gonococcal Laboratory b. Other agents ceftriaxone Institute.

Herpes, neonatal (onset within 42 days after birth)

Tuberculosis suspect and confirmed cases Report within 24 hours to (617) 983-6801 or Toll Free (1-888) MASS-MTB (627-7682) or Confidential Fax (617) 983-6813

• Latent tuberculosis infection Confidential Fax (617) 983-6220 or mail report to address above

Reportable Diseases Primarily Ascertained Through Laboratory Reporting of Evidence of Infection Please work with the laboratories you utilize for diagnostic testing to assure complete reporting.

• Amebiasis • • • Lymphocytic choriomeningitis • • Malaria • • Norovirus • Cryptococcosis • Pneumococcal disease, invasive (Streptococcus • Cryptosporidiosis pneumoniae) ( if patient <18 years) • Cyclosporiasis • Pneumococcal disease, invasive, penicillin-resistant • Dengue • Eastern equine encephalitis • Shiga toxin-producing organisms • O157:H7, and other shiga-toxin • producing E. coli • Staphylococcus aureus, methicillin-resistant (MRSA), • Enteroviruses (from CSF) invasive • Giardiasis Staphylococcus aureus, vancomycin-intermediate (VISA) • Group B streptococcus, invasive and vancomycin-resistant (VRSA) • Hepatitis B • Toxoplasmosis • Hepatitis C • • Hepatitis – infectious, not otherwise specified • Vibriosis • Influenza ( if antiviral resistant) West Nile • Legionellosis • Yellow fever

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105 CMR 300.000 Reportable Diseases, Surveillance, and Isolation and Quarantine Requirements, 2nd Edition, August 2009, Page 2 of 2 Effective July 2008

IN ACCORDANCE WITH M.G.L.c. 111D, s. 6., EVIDENCE OF INFECTION* DUE TO THE FOLLOWING INFECTIOUS AGENTS IS REPORTABLE BY ALL CLINICAL LABORATORIES TO THE MASSACHUSETTS DEPARTMENT OF PUBLIC HEALTH *Evidence of infection includes results from culture methods, specific antigen or genomic tests, histology, other microscopy, and clinically-relevant serologic tests. Infection in Massachusetts’ residents, ascertained out-of-state, should also be reported.

REPORT IMMEDIATELY BY PHONE! This includes both suspect and confirmed cases. Telephone: (617) 983-6800 and ask for the Epidemiologist On-Call

• REPORT WITHIN 24 HOURS Telephone: (617) 983-6801 Confidential Fax: (617) 983-6813

“…all laboratories, including those outside of Massachusetts, performing examinations on any specimens derived from Massachusetts residents that yield evidence of infection due to the organisms listed below shall report such evidence of infection directly to the Department through secure electronic laboratory reporting mechanisms, or other method, as defined by the Department.” 105 CMR 300.170

• Anaplasma sp. • Mumps virus (IgM+ only) • Babesia sp. • Mycobacterium africanum, M. bovis Bacillus anthracis • Mycobacterium leprae • , B. bronchiseptica, B. holmseii and Mycobacterium tuberculosis B. parapertussis Neisseria meningitidis (from blood, CSF or other normally • Borrelia burgdorferi sterile body fluid) Brucella sp. • Norovirus • and B. pseudomallei • Plasmodium falciparum, P. malariae, P. ovale, P. vivax • Campylobacter sp. Poliovirus • Chlamydophila psittaci • akari botulinum • • Clostridium difficile Isolates should • Clostridium tetani Rubella virus (IgM+ only) diphtheriae be submitted to • Salmonella sp. (non typhi) • Hinton State Salmonella typhi • Cryptococcus neoformans Laboratory SARS-associated coronavirus • Cryptosporidium sp. • Shiga-toxin producing organisms • Cyclospora cayetanensis Institute. • Shigella sp. • Dengue virus • Staphylococcus aureus enterotoxin producing organisms Eastern equine encephalitis virus • Staphylococcus aureus, methicillin-resistant (MRSA), invasive • Ehrlichia sp. Staphylococcus aureus, vancomycin-intermediate (VISA) and • Entamoeba histolytica vancomycin-resistant (VRSA) • Enteroviruses (from CSF) • Streptococcus pneumoniae (from blood, CSF or other • Escherichia coli O157:H7 or other shiga-toxin producing normally sterile body fluid) ( if patient <18 years) E. coli • Streptococcus pneumoniae, invasive, penicillin-resistant • Toxoplasma sp. • Giardia sp. • Trichinella sp. Group A streptococcus, invasive • Trypanosoma cruzi • Group B streptococcus (from blood, CSF or other normally Vaccinia virus sterile body fluid) Variola virus (from blood, CSF or other normally • Varicella virus (DFA+, viral culture or PCR+) • Vibrio sp. sterile body fluid) MDPH, its authorized agents and local boards Hantavirus West Nile virus of health have the authority to collect pertinent Hemorrhagic fever viruses (including Ebola, Marburg and • Yellow fever virus information as part of epidemiological other filoviruses, arenaviruses, bunyaviruses and flaviviruses) investigations (M.G.L. c. 111, s. 7.). Hepatitis A virus (IgM+ only) • Yersinia sp.

• Hepatitis B virus • Hepatitis C virus HIV/AIDS Surveillance: (617) 983-6560 • Human prion disease (evidence of) • AIDS (CD4 counts <200/ul or <14% total lymphocytes) • Influenza virus ( if antiviral resistant) • Human immunodeficiency virus (HIV)

Influenza A virus, novel Sexually transmitted infections: (617) 983-6940 • Legionella sp. • trachomatis (ophthalmic, genital and neonatal infections, • Leptospira sp. lymphogranuloma venereum) • Listeria sp. • Calymmatobacterium (Donovania) granulomatis • Lymphocytic choriomeningitis virus • Measles virus (IgM+ only) • Herpes simplex virus, neonatal infection (onset within 42 days after birth) Monkeypox or other orthopox virus • (results indicating resistance to fluoroquinolones or ceftriaxone should also be reported) • Treponema pallidum

105 CMR 300.000 Reportable Diseases, Surveillance, and Isolation and Quarantine Requirements, 2nd Edition, August 2009 Effective July 2008

COMMUNICABLE AND OTHER INFECTIOUS DISEASES REPORTABLE IN MASSACHUSETTS TO LOCAL BOARDS OF HEALTH

Note: If these diseases are initially reported to MDPH, local boards of health will be notified.

INITIATE INVESTIGATION IMMEDIATELY FOR BOTH SUSPECT AND CONFIRMED CASES AND NOTIFY MDPH! Telephone: (617) 983-6800 • INITIATE INVESTIGATION AND COMPLETE CASE REPORT AS SOON AS POSSIBLE. (This may include both suspect and confirmed cases.) Confidential Fax: (617) 983-6813

• Amebiasis (Entamoeba histolytica) • Listeriosis (Listeria sp.) • Anaplasmosis (Anaplasma phagocytophilum) • Lyme disease (Borrelia burgdorferi) Any case of an unusual illness • Lymphocytic choriomeningitis Any cluster/outbreak of illness, including but not limited to • Malaria (Plasmodium falciparum, P. malariae, P. vivax, P. ovale) foodborne illness Measles Anthrax (Bacillus anthracis) • Melioidosis (Burkholderia pseudomallei) • Babesiosis (Babesia sp.) Meningitis, bacterial, community acquired Botulism (Clostridium botulinum) • Meningitis, viral (aseptic), and other infectious (non-bacterial) Brucellosis (Brucella sp.) Meningococcal disease, invasive (Neisseria meningitidis) • Campylobacteriosis (Campylobacter sp.) Monkeypox or other orthopox virus • Chagas disease (Trypanosoma cruzi) • Mumps • Cholera () • Norovirus • Creutzfeldt-Jakob disease (CJD) and variant CJD • Pertussis (Bordetella pertussis) • Cryptococcosis (Cryptococcus neoformans) Plague (Yersinia pestis) • Cryptosporidiosis (Cryptosporidium sp.) • Pneumococcal disease, invasive (Streptococcus pneumoniae) • Cyclosporiasis (Cyclospora cayetanensis) Polio • Dengue • Psittacosis (Chlamydophila psittaci) Diphtheria (Corynebacterium diphtheriae) • Q fever (Coxiella burnetii) Eastern equine encephalitis Rabies in humans • Ehrlichiosis (Ehrlichia sp.) • Reye syndrome • Encephalitis, any cause Rheumatic fever • Escherichia coli O157:H7, and other shiga-toxin producing • Rickettsialpox () E. coli • Rocky Mountain spotted fever (Rickettsia rickettsii) • Food poisoning and toxicity (includes poisoning by ciguatera, Rubella scombrotoxin, mushroom toxin, tetrodotoxin, paralytic shell- • Salmonellosis (Salmonella sp., non typhi) fish and amnesic shellfish) Severe acute respiratory syndrome (SARS) • Giardiasis (Giardia sp.) • Shiga-toxin producing organisms • Glanders (Burkholderia mallei) • Shigellosis (Shigella sp.) Group A streptococcus, invasive Smallpox • Group B streptococcus, invasive Tetanus (Clostridium tetani) Haemophilus influenzae, invasive • • Hansen’s disease (leprosy) • Toxoplasmosis (Toxoplasma sp.) Hantavirus • Trichinosis (Trichinella sp.) Hemolytic uremic syndrome Tularemia (Francisella tularensis) Hepatitis A (IgM+ only) Typhoid fever (Salmonella typhi) • Hepatitis B • Typhus (Rickettsia prowazekii) • Hepatitis C • Varicella (chickenpox) • Hepatitis – infectious, not otherwise specified • Vibriosis (Vibrio sp.) • Influenza Viral hemorrhagic fevers Influenza A virus, novel West Nile Influenza, pediatric deaths (<18 years) • Yellow fever • Legionellosis (Legionella sp.) • Yersiniosis (Yersinia sp.) • Leptospirosis (Leptospira sp.) Important Note: During outbreaks, MDPH and local boards of health may request that other diseases be reportable immediately.

105 CMR 300.000 Reportable Diseases, Surveillance, and Isolation and Quarantine Requirements, 2nd Edition, August 2009