(12) United States Patent (10) Patent No.: US 6,541,479 B1 Mehanna Et Al
USOO6541479 B1 (12) United States Patent (10) Patent No.: US 6,541,479 B1 Mehanna et al. (45) Date of Patent: Apr. 1, 2003 (54) CALCIUM CHANNEL BLOCKERS 5,132,106 A 7/1992 Tuloup et al. ................ 424/70 5,134,139 A 7/1992 Kawai et al. ............... 514/211 (75) Inventors: Ahmed S. Mehanna, Sudbury; Jinyung 5,135,936 A 8/1992 Adams et al. .............. 514/305 T. Kim, Boston, both of MA (US) 5,144,029 A 9/1992 Ward et al. ................. 540/610 5,198.433 A 3/1993 Palfreyman et al. ........ 514/212 5,276,026 A 1/1994 Barrish et al. .............. 514/212 (73) ASSignee: Masays sole of Pharmacy, 5,281,592 A 1/1994 Ozeki et al. ............. 514/224.2 s 5,344,830 A 9/1994 Mills et al. .............. 514/235.8 (*) Notice: Subject to any disclaimer, the term of this rig: A : y R t t r 5. patent is extended or adjusted under 35 5,496,815. A 3/1996 Ozeki et al. ............. 514/224.2 U.S.C. 154(b) by 0 days. 5,514,693 A 5/1996 Cozzi et al. ................ 514/341 5,607,939 A 3/1997 Kato et al. .................. 514/278 (21) Appl. No.: 08/982,953 5,623,051. A 4/1997 Catterall et al. ............ 530/324 (22) Filed: Dec. 2, 1997 OTHER PUBLICATIONS (51) Int. Cl." .............................................. A61K31/495 Abstract to Gialdi et al. of CA56:4664g, Mar. 8, 1962.* (52) U.S. Cl. ................................... 514/255.01: 514/310 Fugita, M. et al., "Synthesis and Ca" Antagonistic Activity (58) Field of Search ............................
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