Brevets D'invention Uitvindingsoctrooien
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Historische Wertpapiere: Los 1003 Ausruf: 27 € Los 1001 Ausruf: 15 € Phoenix Gummiwerke AG, Hamburg- Los 1000 Ausruf: 16 € Parkbrauerei AG, Pirmasens , August Harburg
Historische Wertpapiere: Los 1003 Ausruf: 27 € Los 1001 Ausruf: 15 € Phoenix Gummiwerke AG, Hamburg- Los 1000 Ausruf: 16 € Parkbrauerei AG, Pirmasens , August Harburg. 3 verschiedene Nennwerte. a.) Paderborner Elektricitätswerk und 1991, Aktie 50 DM, # 3013 50 DM, Juli 1969 # 208100; b.) 100 DM, Straßenbahn-AG, Paderborn, 29.3.1913, Gründung im Sept. 1888 als Parkbrauereien Oktober 1952 # 20044; c.) 1.000 DM, Namensaktie 1.000 M, #1258 Zweibrücken vorm. Schmidt-Jakoby; im Dez. Oktober 1952 # 4120 des gleichen Jahres Zusammenschluss mit der Auflage nur 100 Stück, eingetragen auf Die Die Brüder Albert und Louis Cohen aus Pirmasenser Brauerei “Zum Park” von Jacob Stadtgemeinde Paderborn. Gründung 1909 zur Hamburg gründen aufgrund von vielen Seitz zur Parkbrauerei Zweibrücken-Pirmasens. Versorgung von Stadt und Kreis Paderborn, Standortvorteilen 1856 in Hamburg-Harburg 1912 Fusion mit der Pirmasenser Bürgerbräu Kreis Büren und Freistaat Lippe mit elektrischer eine Gummifabrik. Der Name "Phoenix" wird AG vorm. Semmler zur Park- und Bürgerbräu Energie. 41 Städte und Landgemeinden wurden erst 1864 zum ersten Male mit der Gummifabrik AG. 1938 Umfirmierung in Parkbrauerei AG aus dem Kraftwerk Paderborn versorgt, das in Verbindung gebracht. Produziert wurden Pirmasens-Zweibrücken-Pirmasens". Neben 1927 mit dem RWE-Fernleitungsnetz Gummischuhe und gummierte Stoffe auf der Brauerei in Pirmasens und der Mälzerei in zusammengeschaltet wurde. Das Naturkautschukbasis. 1872 wurde dann die Kirchheimbolanden werden heute Straßenbahnnetz in 1.000-mm-Spur gliederte Phoenix Gummiwerke AG gegründet und diese Niederlassungen/Verkaufsbüros in sich in das auf preußischem Gebiet liegende schloss sich dann mit der österreichischen Zweibrücken, Saarbrücken, Mannheim und Paderborner Netz (zus. 25 km) und das im Firma J. -
A Project Report on ³INVENTORY MANAGEMENT´
A Project Report on ³INVENTORY MANAGEMENT´ SUBMITTED BY: Mujif Rahuman M. 520828621 Operations Management Submitted in fulfillment of the requirement of IVth Semester of MBA course, Sikkim Manipal University 1 Table of Contents INTRODUCTION INVENTORY MANAGEMENT««««««««2 SIEMENS«««««««««««««««««««««.........8 OBJECTIVES AND NEED OF SUPPLY CHAIN MANAGEMENT..16 ACTIVITIES/FUNCTIONS OF SCM IN SIEMENS«««««.20 INVENTORY CONTROL MANAGEMENT««««««««25 WAREHOUSE««««««««««««««««««««..43 TRANSPORTATION««««««««««««««««.«.45 DISTRIBUTION«««««««««««««««««««..48 PACKAGING AND LABELLING««««««««««««.53 CONCLUSION««««««««««««««««««««.59 2 INVENTORY MANAGEMENT 1. INTRODUCTION DEFINATION AND MEANING Inventory is a list of goods and materials, or those goods and materials themselves, held available in stock by a business. Inventory are held in order to manage and hide from the customer the fact that manufacture/supply delay is longer than delivery delay, and also to ease the effect of imperfections in the manufacturing process that lower production efficiencies if production capacity stands idle for lack of materials. The reasons for keeping stock All these stock reasons can apply to any owner or product stage. Buffer stock is held in individual workstations against the possibility that the upstream workstation may be a little delayed in providing the next item for processing. Whilst some processes carry very large buffer stocks, Toyota moved to one (or a few items) and has now moved to eliminate this stock type. Safety stock is held against process or machine failure in the hope/belief that the failure can be repaired before the stock runs out. This type of stock can be eliminated by programmes like Total Productive Maintenance Overproduction is held because the forecast and the actual sales did not match. -
REGENERATIVE AGRICULTURE and the SOIL CARBON SOLUTION SEPTEMBER 2020
REGENERATIVE AGRICULTURE and the SOIL CARBON SOLUTION SEPTEMBER 2020 AUTHORED BY: Jeff Moyer, Andrew Smith, PhD, Yichao Rui, PhD, Jennifer Hayden, PhD REGENERATIVE AGRICULTURE IS A WIN-WIN-WIN CLIMATE SOLUTION that is ready for widescale implementation now. WHAT ARE WE WAITING FOR? Table of Contents 3 Executive Summary 5 Introduction 9 A Potent Corrective 11 Regenerative Principles for Soil Health and Carbon Sequestration 13 Biodiversity Below Ground 17 Biodiversity Above Ground 25 Locking Carbon Underground 26 The Question of Yields 28 Taking Action ACKNOWLEDGMENTS 30 Soil Health for a Livable Future Many thanks to the Paloma Blanca Foundation and Tom and Terry Newmark, owners of Finca Luna Nueva Lodge and regenerative farm in 31 References Costa Rica, for providing funding for this paper. Tom is also the co-founder and chairman of The Carbon Underground. Thank you to Roland Bunch, Francesca Cotrufo, PhD, David Johnson, PhD, Chellie Pingree, and Richard Teague, PhD for providing interviews to help inform the paper. EXECUTIVE SUMMARY The environmental impacts of agricultural practices This introduction is co-authored by representatives of two The way we manage agricultural land 140 billion new tons of CO2 contamination to the blanket of and translocation of carbon from terrestrial pools to formative organizations in the regenerative movement. matters. It matters to people, it matters to greenhouse gases already overheating our planet. There is atmospheric pools can be seen and felt across a broad This white paper reflects the Rodale Institute’s unique our society, and it matters to the climate. no quarreling with this simple but deadly math: the data are unassailable. -
We Are on the Right Track for Ensuring Our Success
s »We have made great progress in »We are on the right track for networking our internal value ensuring our success as the chain electronically and in linking it to our customers, suppliers and Global network of innovation.« partners. This is enabling us to accelerate processes and cut costs.« Annual Report 2001 Annual s Annual Report 2001 Siemens Aktiengesellschaft Order No. A19100-F-V055-X-7600 Siemens Siemens is a network encompassing well over 400,000 people in 190 countries. information on contents for external orders We take pride in possessing in-depth knowledge of customers' requirements, the Telephone +49 89 636-33032 (Press Office) e-mail [email protected] expertise to create innovative solutions in electrical engineering and electronics, and +49 89 636-32474 (Investor Relations) Internet http://www.siemens.de/geschaeftsbericht_2001/order Fax +49 89 636-32825 (Press Office) Telephone +49 89 636-32910 the experience to successfully navigate even rough economic waters. But our greatest +49 89 636-32830 (Investor Relations) Fax +49 89 636-32908 e-mail [email protected] asset is undoubtedly our people, with their unparalleled motivation and their passion [email protected] for outperforming our competitors. Linked via a global network that enables them address for internal orders to exchange ideas with colleagues around the world, Siemens employees strive Siemens AG Wittelsbacherplatz 2 LZF, Fürth-Bislohe continuously to increase company value. D-80333 Munich Intranet http://c4bs.spls.de/ We at Siemens do not measure value solely in terms of short-term profitability. For Federal Republic of Germany Fax +49 911 654-4271 Internet http://www.siemens.com German Order no. -
Sustainable Success Is Our Number One Priority
Sustainable success is our number one priority. s Annual Report 2002 BUSINESS EXCELLENCE For 155 years, the Siemens name has been synonymous with cutting- edge technologies and continuous growth in profitability. With our wide array of products, systems and services, we are world leaders in information and communications, automation and control, power, medical solutions, trans- portation and lighting. Sustainable success is our number one priority. Our activities focus on meeting the needs of our customers and creating value for our shareholders and employees. Our innovations Ð generated in our own lab- oratories and in cooperation with customers, business partners and universi- ties Ð are our greatest strength. Siemens’ global network of innovation is developing new products and services for a world that Ð while limited in resources Ð is boundless in possibilities. GLOBAL PRESENCE 12 Letter to our shareholders 38 Information for shareholders* 140 Supervisory Board 18 At a glance 40 Report of the Supervisory Board 142 Managing Board 20 Business areas 48 Management’s discussion and analysis 146 Financial calendar 32 Corporate governance 86 Consolidated financial statements Corporate structure** * with separate table of contents ** see fold-out inside back cover financial highlights (in millions of euros) 2002(1) 2001(1) 2000(1) New orders 86,214 92,528 83,426 Net sales 84,016 87,000 77,484 Net income 2,597 2,088 8,860 Net cash provided by operating activities 5,564 7,016 6,154 Net cash used in investing activities (810) (5,886) (435) Research and development expenses 5,819 6,782 5,848 Shareholders’ equity (September 30) 23,521 23,812 28,480 Employees (September 30, in thousands) 426 484 448 FINANCIAL (1) Fiscal year (October 1 Ð September 30) INTEGRITY CORPORATE RESPONSIBILITY 4 Business excellence At Siemens, we view innovation as To ensure that our businesses are world the key to entrepreneurial success. -
Organic Cation Transporter 3 Mediates Cisplatin and Copper Cross-Resistance in Hepatoma Cells
www.impactjournals.com/oncotarget/ Oncotarget, 2018, Vol. 9, (No. 1), pp: 743-754 Research Paper Organic cation transporter 3 mediates cisplatin and copper cross-resistance in hepatoma cells Sarah Guttmann1,*, Gursimran Chandhok1,2,*, Sara Reinartz Groba1, Christoph Niemietz1, Vanessa Sauer1, Amanda Gomes1,3, Giuliano Ciarimboli4, Uwe Karst5, Andree Zibert1 and Hartmut H. Schmidt1 1Medizinische Klinik B für Gastroenterologie und Hepatologie, Universitätsklinikum Münster, Münster, Germany 2Present address: Monash Biomedicine Discovery Institute, and Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia 3Present address: Wilson Disease Clinic, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India 4Universitätsklinikum Münster, Medizinische Klinik D, Experimentelle Nephrologie, Münster, Germany 5Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany *These authors contributed equally to this work Correspondence to: Hartmut H. Schmidt, email: [email protected] Keywords: OCT3; ATP7B; MT1; cisplatin; copper cross-resistance Received: June 30, 2017 Accepted: November 15, 2017 Published: December 12, 2017 Copyright: Guttmann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Platinum-based drugs are first-line compounds in the treatment of many solid cancers. Major obstacles are tumors that become resistant and toxic side effects, both largely due to the expression of transporters that mediate the cellular processing of platinum. In this study, we addressed the establishment of cisplatin resistance in the absence of copper transporter ATP7B that has been previously found to be overexpressed in various resistant cells. -
Aufstellung Des Anteilsbesitzes Des Siemens Konzerns Gemäß § 313 Abs
Aufstellung des Anteilsbesitzes des Siemens Konzerns gemäß § 313 Abs. 2 HGB Kapital- anteil Stand 30.9.2002 in % I. Verbundene Unternehmen A. Konsolidiert 1. Deutschland (208 Gesellschaften) ACHH Grundstücksentwicklungs-GmbH & Co. OHG, Erlangen 1004) ACHH Grundstücksentwicklungs-Verwaltungsgesellschaft mbH, Erlangen 100 Alarmcom GmbH, Filderstadt-Bonlanden 100 Allgemeine Assekuranz-Vermittlung Duisburg GmbH, Duisburg 100 Atecs Mannesmann AG, Düsseldorf 1001) Audio Service GmbH, Herford 100 BFE Studio und Medien Systeme GmbH, Mainz 100 bibis Information Technology and Services GmbH, Dortmund 100 CAPTA Grundstücks-Verwaltungsgesellschaft mbH & Co. OHG, Grünwald 1004) Divipart Aktiengesellschaft & Co. Grundstücks KG, Frankfurt am Main 100 Duewag AG, Krefeld-Uerdingen 99 Elektro-Röhren-Gesellschaft beschränkt haftende OHG, Göttingen 100 Elektro-Röhren-Gesellschaft mbH, Göttingen 100 Fertigungscenter für Elektrische Anlagen Bremen GmbH, Bremen 100 Fertigungscenter für Elektrische Anlagen Erlangen GmbH, Erlangen 100 Fertigungscenter für Elektrische Anlagen Hannover GmbH, Hannover 100 Fertigungscenter für Elektrische Anlagen Köln GmbH, Köln 100 Fertigungscenter für Elektrische Anlagen Langen GmbH, Mörfelden-Walldorf 100 Fertigungscenter für Elektrische Anlagen St. Ingbert GmbH, St. Ingbert 100 Frankendata Softwareengineering GmbH & Co. KG, Erlangen 100 Frankendata Softwareengineering Verwaltungsgesellschaft mbH, Erlangen 100 Gerap Grundbesitz- und Verwaltungsgesellschaft mbH, Frankfurt am Main 100 GIT Gesellschaft für Ingenieur-Technik mbH, -
Chest Physiotherapy Improves Lung Aeration in Hypersecretive Critically Ill Patients: a Pilot Randomized Physiological Study
Longhini et al. Critical Care (2020) 24:479 https://doi.org/10.1186/s13054-020-03198-6 RESEARCH Open Access Chest physiotherapy improves lung aeration in hypersecretive critically ill patients: a pilot randomized physiological study Federico Longhini1, Andrea Bruni1, Eugenio Garofalo1, Chiara Ronco2, Andrea Gusmano2, Gianmaria Cammarota3, Laura Pasin4, Pamela Frigerio5, Davide Chiumello6,7,8 and Paolo Navalesi4,9* Abstract Background: Besides airway suctioning, patients undergoing invasive mechanical ventilation (iMV) benefit of different combinations of chest physiotherapy techniques, to improve mucus removal. To date, little is known about the clearance effects of oscillating devices on patients with acute respiratory failure undergoing iMV. This study aimed to assess (1) the effects of high-frequency chest wall oscillation (HFCWO) on lung aeration and ventilation distribution, as assessed by electrical impedance tomography (EIT), and (2) the effect of the association of HFCWO with recruitment manoeuvres (RM). Methods: Sixty critically ill patients, 30 classified as normosecretive and 30 as hypersecretive, who received ≥ 48 h of iMV, underwent HFCWO; patients from both subgroups were randomized to receive RM or not, according to two separated randomization sequences. We therefore obtained four arms of 15 patients each. After baseline record (T0), HFCWO was applied for 10 min. At the end of the treatment (T1) or after 1 (T2) and 3 h (T3), EIT data were recorded. At the beginning of each step, closed tracheobronchial suctioning was performed. In the RM subgroup, tracheobronchial suctioning was followed by application of 30 cmH2O to the patient’s airway for 30 s. At each step, we assessed the change in end-expiratory lung impedance (ΔEELI) and in tidal impedance variation (ΔTIV), and the center of gravity (COG) through EIT. -
Tesi Dottorato Barbara Giacomini
UNIVERSITA’ DEGLI STUDI DI MILANO Dottorato in Biologia Vegetale e Produttività della Pianta Coltivata XXI ciclo Individuazione e caratterizzazione di proteine coinvolte nella regolazione trascrizionale delle risposte alla solfo-carenza e a cadmio delle piante Area disciplinare: AGR/13, Chimica Agraria Docente guida: Prof. Gian Attilio Sacchi Docente di supporto: Dott. Fabio Francesco Nocito Coordinatore: Prof. Daniele Bassi Tesi di Dottorato di: Barbara GIACOMINI Matr. n. R06714 Anno Accademico 2007-2008 Al mio Papà sicura che anche dove sei ora sarai orgoglioso di me… INDICE Introduzione Pag. 3 Obiettivo Pag. 22 Materiali e Metodi Pag. 24 Risultati e Discussione Pag. 53 Conclusioni Pag. 69 Figure Pag. 71 Allegati Pag. 104 Bibliografia Pag. 129 2 INTRODUZIONE Lo zolfo e le piante Lo zolfo è un nutriente essenziale per la crescita delle piante che lo utilizzano prevalentemente per la sintesi di due amminoacidi, cisteina (Cys) e metionina (Met), e di numerosi metaboliti derivanti da questi amminoacidi. Il nutriente si ritrova, infatti, in glutatione (GSH), fitochelatine (PC), nei clusters ferro-zolfo, in vitamine e cofattori (biotina, tiamina, CoA, S-adenosil-Met) e in una varietà di composti secondari (glucosinolati, allil Cys, solfossidi). Lo zolfo è coinvolto anche nelle modificazioni secondarie di composti quali flavonoidi, steroidi, polisaccaridi e lipidi (Saito 2000; Leustek 2002; Maruyama-Nakashita et al. 2003; Saito 2004). Tali molecole sono coinvolte in una moltitudine di processi biochimici e fisiologici, inclusi la regolazione di attività enzimatiche, cicli redox e la detossificazione di metalli pesanti e xenobiotici (Noctor et al . 1998; Leustek et al . 2000; Rausch e Wachter 2005). In generale lo zolfo non ricopre specifici ruoli strutturali nei sistemi biologici ma piuttosto è responsabile delle proprietà catalitiche e elettrochimiche dei composti che lo contengono. -
Harnessing Microbes for Sustainable Development: Food Fermentation As a Tool for Improving the Nutritional Quality of Alternative Protein Sources
nutrients Review Harnessing Microbes for Sustainable Development: Food Fermentation as a Tool for Improving the Nutritional Quality of Alternative Protein Sources Anna Kårlund 1 , Carlos Gómez-Gallego 1 , Jenni Korhonen 1, Outi-Maaria Palo-oja 2 , Hani El-Nezami 1,3 and Marjukka Kolehmainen 1,* 1 Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland; anna.karlund@uef.fi (A.K.); carlos.gomezgallego@uef.fi (C.G.-G.); jenni.korhonen@uef.fi (J.K.); hani.el-nezami@uef.fi (H.E.-N.) 2 Business School, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland; outi-maaria.palo-oja@uef.fi 3 School of Biological Sciences, University of Hong Kong, Pok Fu Lam Road, Hong Kong, China * Correspondence: marjukka.kolehmainen@uef.fi; Tel.: +358-40-355-3617 Received: 28 February 2020; Accepted: 7 April 2020; Published: 8 April 2020 Abstract: In order to support the multiple levels of sustainable development, the nutritional quality of plant-based protein sources needs to be improved by food technological means. Microbial fermentation is an ancient food technology, utilizing dynamic populations of microorganisms and possessing a high potential to modify chemical composition and cell structures of plants and thus to remove undesirable compounds and to increase bioavailability of nutrients. In addition, fermentation can be used to improve food safety. In this review, the effects of fermentation on the protein digestibility and micronutrient availability in plant-derived raw materials are surveyed. The main focus is on the most important legume, cereal, and pseudocereal species (Cicer arietinum, Phaseolus vulgaris, Vicia faba, Lupinus angustifolius, Pisum sativum, Glycine max; Avena sativa, Secale cereale, Triticum aestivum, Triticum durum, Sorghum bicolor; and Chenopodium quinoa, respectively) of the agrifood sector. -
Community Guide 2017
50th 1 Anniversary Community Guide 2017 Copyright © 2017 San Geronimo Valley Community Center All stories, articles, photographs, images, and poems are copyright of their respective creators as indicated herein, and are reproduced here with permission. Printed in the United States of America by McNaughton & Gunn Printed on recycled paper Publisher: San Geronimo Valley Community Center Editor: Barbara S. Brauer Photo Editor: Anne McClain Design & Production: David Russ Cover Design: Anne McClain Page Footers: Anne McClain, Molly Edwards, Fred (Lee) Berensmeier Lagunitas School Map: Anne McClain Valley Map: Fred (Lee) Berensmeier Spanish Translation: Victor Reyes, Nicole Ramirez Advertising Sales: Larry Rippee Funding: County of Marin Community Service Grant; Marin Municipal Water District; and San Geronimo Valley Community Center Community Guide Editorial Committee: Barbara S. Brauer, Chair, Jean Berensmeier, Dave Cort, Don Holmlund, Anne McClain, Alexander McQuilkin, Larry Rippee, Diana Rocha, David Russ, Suzanne Sadowsky, and Margo Schmidt Proofreaders: Jean Berensmeier, Barbara S. Brauer, Roberta Floden, Michel Kotski, Anne McClain, Suzanne Sadowsky and Margo Schmidt Acknowledgments We owe a deep debt of gratitude to all the many community members who shared the stories, photos, and memories that so enrich this Community Guide. We would particularly like to thank the following individuals who responded so gener- ously to our requests for materials: Bob Baker, John Beckerley, Jean Berensmeier, Paul Berensmeier, Frank Binney, Lau- rence -
Canada Rail Opportunities Scoping Report Preface
01 Canada Rail Opportunities Canada Rail Opportunities Scoping Report Preface Acknowledgements Photo and image credits The authors would like to thank the Agence Métropolitaine de Transport following organisations for their help and British Columbia Ministry of Transportation support in the creation of this publication: and Infrastructure Agence Métropolitaine de Transport BC Transit Alberta Ministry of Transport Calgary Transit Alberta High Speed Rail City of Brampton ARUP City of Hamilton Balfour Beatty City of Mississauga Bombardier City of Ottawa Calgary Transit Edmonton Transit Canadian National Railway Helen Hemmingsen, UKTI Toronto Canadian Urban Transit Association Metrolinx Edmonton Transit OC Transpo GO Transit Sasha Musij, UKTI Calgary Metrolinx Société de Transport de Montréal RailTerm TransLink SNC Lavalin Toronto Transit Commission Toronto Transit Commission Wikimedia Commons Wikipedia Front cover image: SkyTrain in Richmond, Vancouver Canada Rail Opportunities Contents Preface Foreword 09 About UK Trade & Investment 10 High Value Opportunities Programme 11 Executive Summary 12 1.0 Introduction 14 2.0 Background on Canada 15 2.1 Macro Economic Review 16 2.2 Public-Private Partnerships 18 3.0 Overview of the Canadian Rail Sector 20 4.0 Review of Urban Transit Operations and Opportunities by Province 21 4.1 Summary Table of Existing Urban Transit Rail Infrastructure and Operations 22 4.2 Summary Table of Key Project Opportunities 24 4.3 Ontario 26 4.4 Québec 33 4.5 Alberta 37 4.6 British Columbia 41 5.0 In-Market suppliers 45 5.1 Contractors 45 5.2 Systems and Rolling Stock 48 5.3 Consultants 49 6.0 Concluding Remarks 51 7.0 Annexes 52 7.1 Doing Business in Canada 52 7.2 Abbreviations 53 7.3 Bibliography 54 7.4 List of Reference Websites 56 7.5 How can UKTI Help UK Organisations Succeed in Canada 58 Contact UKTI 59 04 Canada Rail Opportunities About the Authors David Bill Helen Hemmingsen David is the International Helen Hemmingsen is a Trade Officer Development Director for the UK with the British Consulate General Railway Industry Association (RIA).