Additional Table 3 Transcription factors (TFs) information Total TFs 24 h TFs 48 h TFs TFs Target Genes 18 5 17 Cebpa Cebpa Cebpa Egr2 Cebpa Cebpa Cdkn1a Cebpb Stat3 Cebpb Cebpa Afp Egr1 Wt1 Egr2 Cebpa Gnrh1 Egr2 Tp53 Ets1 Cebpa Got1 Ets1 Egr1 Pax8 Cebpa Cpb2 Hif1a Pparg Cebpa Cyp2c12 Hoxa1 Rela Cebpa Klf5 Junb Sp4 Cebpa A2m Pax8 Stat1 Cebpa Thrsp Pparg Stat3 Cebpa Orm1 Rela Tp53 Cebpa Pla2g2a Sp4 Usf1 Cebpa Arg1 Stat1 Usf2 Cebpa Mmp2 Stat3 Hif1a Cebpa Tat Tp53 Hoxa1 Cebpa Xdh Usf1 Junb Cebpa Spin2a Usf2 Wt1 Cebpa Sst Wt1 Cebpa Mt1a Cebpa Ptgs2 Cebpa Slc2a2 Cebpa Fabp2 Cebpa Adh1 Cebpa Ucp1 Cebpb Cebpa Cebpb Adh1 Cebpb Cyp2c12 Cebpb Cgm3 Cebpb Arg1 Cebpb A2m Cebpb Ccl2 Cebpb Pla2g2a Cebpb Col1a1 Cebpb Cyp7a1 Cebpb Sst Cebpb Xdh Cebpb Ptgs2 Cebpb Ddit3 Cebpb Pdgfra Cebpb Ucp1 Cebpb Afp Cebpb Cpb2 Cebpb Star Cebpb Prl Cebpb Slc2a2 Egr1 Lhb Egr1 Adrb1 Egr1 Pgy1 Egr1 Th Egr1 Dlk1 Egr1 Chrna7 Egr1 Cntn1 Egr1 Slc9a3 Egr1 Pdgfb Egr1 Aldoc Egr1 Me1 Egr1 Pdgfa Egr1 Ptp4a1 Egr1 Serpine1 Egr1 Atp2a2 Egr1 Lhcgr Egr1 Mmp14 Egr1 Myh6 Egr1 Nudt6 Egr1 F3 Egr1 Id1 Egr2 Aldoc Ets1 Cited2 Ets1 Thy1 Ets1 Lhb Ets1 Runx2 Ets1 Ccnd1 Ets1 Spp1 Ets1 Casp3 Ets1 Prl Ets1 Mmp2 Ets1 Tat Ets1 Ucp1 Ets1 Ccnb1 Ets1 Cdkn1a Ets1 Mmp9 Hif1a Th Hif1a Wt1 Hif1a Vhl Hif1a Nos2 Hif1a Slc2a1 Hif1a Tfrc Hif1a Nppa Hif1a Serpine1 Hif1a Gck Hif1a Adra1a Hif1a Plat Hif1a Hmox1 Hif1a Mt1a Hif1a Pklr Hif1a Cdkn1a Hoxa1 Col1a1 Junb Th Junb Vgf Junb Timp1 Pax8 Wbp2 Pax8 Slc5a5 Pax8 Tg Pparg Hadha Pparg Ucp2 Pparg Aldh3a1 Pparg Nr1d1 Pparg Mapk1 Pparg Atp2a2 Pparg Ptgs2 Pparg Rxrg Pparg Gck Pparg Agtr1a Pparg Ucp1 Pparg Slc2a2 Pparg Rxra Rela Nos2 Rela Ccl2 Rela Col1a1 Rela Cxcl2 Rela Agt Rela Adh1 Rela Tnf Rela Ptgds Rela Orm1 Rela Pla2g2a Rela Tnfsf15 Rela Nr4a1 Rela Icam1 Rela Ar Sp4 Slc9a2 Stat1 Spin2a Stat1 Icam1 Stat1 A2m Stat1 Cyp2c12 Stat3 Cyp2c12 Stat3 Rln1 Stat3 Fgg Stat3 Pomc2 Stat3 Spin2a Tp53 Bax Tp53 Bdkrb2 Tp53 Ccng1 Tp53 Bcl2 Tp53 Tnfsf6 Tp53 Apex1 Tp53 Egr1 Tp53 Ccnb1 Tp53 Cdkn1a Tp53 Pcna Tp53 Pgy1 Usf1 Myl2 Usf1 Hmox1 Usf1 Adh1 Usf1 Ins2 Usf1 Bdnf Usf1 Calca Usf1 Tac1 Usf1 Chrna7 Usf1 Bhlhb2 Usf1 Tp53 Usf1 Cpt1b Usf1 Gcgr Usf1 Apeg1 Usf1 Aldoc Usf1 App Usf1 Serpine1 Usf1 Atp2a2 Usf1 Tgfb2 Usf1 Igfbp1 Usf1 Spp1 Usf1 Myh6 Usf2 Myl2 Usf2 Tac1 Usf2 Calca Usf2 Bhlhb2 Usf2 Tp53 Usf2 Cpt1b Usf2 Gcgr Usf2 Apeg1 Usf2 App Usf2 Serpine1 Usf2 Atp2a2 Usf2 Tgfb2 Usf2 Igfbp1 Usf2 Gck Usf2 Spp1 Usf2 Hmox1 Usf2 Pklr Usf2 Adh1 Usf2 Bdnf Wt1 Igf1r Wt1 Igf2 Wt1 Tp53 Wt1 Nos2 Wt1 Inha Additional Table 3 Transcription factors (TFs) information Best Promoter Best Binding Quality 85326 known 100562 known 94327 known 94729 known 86825 known 94738 known 86859 known 94765 known 112782 known 87654 known 104735 known 105127 known 88406 known 97589 known 97747 known 106268 known 106752 known 91523 known 98283 known 92794 known 98587 known 99057 known 99122 known 98150 known 85326 known 99122 known 86859 known 88207 known 88406 known 112782 known 89151 known 105127 known 89263 known 106181 known 91523 known 106268 known 92794 known 107866 known 94274 known 98150 known 94327 known 94738 known 95680 known 96595 known 98587 known 85447 known 86593 known 104310 known 87211 known 106794 known 87779 known 108207 known 88382 known 108688 known 90295 known 136771 known 91750 known 111682 known 91805 known 91949 known 93537 known 94599 known 95014 known 98618 known 99045 known 101375 known 90295 known 84818 known 109415 known 85447 known 110858 known 87190 known 94403 known 95744 known 96595 known 97589 known 97747 known 98150 known 99858 known 100562 known 101531 known 87211 known 101100 known 103348 known 89112 known 104947 known 91070 known 105181 known 91805 known 94074 known 94719 known 95656 known 97530 known 98283 known 98804 known 100562 known 89263 known 87211 known 92362 known 111925 known 89807 known 95294 known 107995 known 106332 known 85700 known 88864 known 90068 known 90926 known 91949 known 92794 known 92869 known 94074 known 96203 known 98150 known 98587 known 100798 known 89112 known 89151 known 89263 known 94336 known 97929 known 99122 known 100668 known 102752 known 104735 known 105127 known 105887 known 108310 known 109294 known 111887 known 110964 known 106752 known 109294 known 112782 known 86859 known 86859 known 86903 known 98735 known 106343 known 106752 known 87857 known 106764 known 90683 known 92623 known 93292 known 94567 known 97052 known 99858 known 100562 known 102206 known 104310 known 85855 known 97530 known 99122 known 87216 known 101112 known 87494 known 102892 known 87779 known 103315 known 88946 known 108600 known 89675 known 111091 known 90295 known 91244 known 91805 known 91949 known 93131 known 93903 known 94403 known 95014 known 85855 known 102892 known 87494 known 103315 known 88946 known 108600 known 89675 known 111091 known 91244 known 91805 known 91949 known 93131 known 93903 known 94074 known 94403 known 97530 known 98804 known 99122 known 101112 known 85550 known 87223 known 88946 known 89112 known 111104 known