2011 Portfolio Analysis Projects
Please note that data are not yet final; additional projects may be added.
Table of Contents
Question Page Number
Question 1: When should I be concerned? 2
Question 2: How can I understand what is happening?
Question 3: What caused this to happen and can it be prevented?
Question 4: Which treatments and interventions will help?
Question 5: Where can I turn for services?
Question 6: What does the future hold, particularly for adults?
Question 7: What other infrastructure and surveillance needs must be met?
QUESTION 1: WHEN SHOULD I BE CONCERNED?
This document is for discussion purposes only and does not reflect the decisions of the IACC
1.S.A
Develop, with existing tools, at least one efficient diagnostic instrument (i.e., briefer, less time intensive) that is valid in diverse populations for use in large-scale studies by 2011. IACC Recommended Budget: $5,300,000 over 2 years.
Project Title Principal Investigator Institution Funding Funder
Biomarkers and diagnostics for ASD Bahn, Sabine Institute of Biotechnology $149,600 Autism Speaks
Quantitative analysis of craniofacial dysmorphology in University of Massachusetts Deutsch, Curtis $137,861 Simons Foundation autism Medical School
National Institutes
Early detection of pervasive developmental disorders Fein, Deborah University of Connecticut $1,025,577 of Health
Improving accuracy and accessibility of early autism Howard, National Institutes Total Child Health, Inc. $518,904 screening Barbara of Health
Assessing the accuracy of rapid phenotyping of Law, Paul Kennedy Krieger Institute $ 124998 Autism Speaks nonverbal autistic children
Autism dysmorphology measure validity study Miles, Judith University of Missouri $195,570 Simons Foundation
Southwestern Autism Southwest Autism Validation of a screening questionnaire for ASD in Smith, Research & Resource Center $0 Research & older children Christopher (SARRC) Resource Center
Multimedia tool for psychology graduate student ASD Strickland, National Institutes Virtual Reality Aids, Inc. $449,703 assessment training Dorothy of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
1.S.B
Validate and improve the sensitivity and specificity of new or existing screening and diagnostic tools, including comparative studies of general developmental screening versus autism-specific screening tools, in both high-risk and population-based samples, including those from resource- poor international settings and those that are diverse in terms of age, socio-economic status, race, ethnicity, gender, characteristics of ASD, and general level of functioning by 2012. IACC Recommended Budget: $5,400,000 over 3 years.
Project Title Principal Investigator Institution Funding Funder
Attention to social and nonsocial events in children Bahrick, Florida International $0 Autism Speaks with autism Lorraine University
Health Resources Leadership Education in Neurodevelopmental University of Alabama at Biasini, Fred $2,500 and Services Disabilities Birmingham Administration University of Georgia – Carolina Autism Resource and Evaluation Center (UGA-CARES): A Campbell, Organization for University of Georgia $0 collaborative autism screening project utilizing web- Jonathan Autism Research
based technology Center for Autism Validation of a Korean version of the QABF with Center for Autism and Dixon, Dennis $10,320 and Related children with ASD Related Disorders (CARD) Disorders
Agency for Indiana University - Purdue Healthcare
Computer Assisted Autism Care (CAAC) Downs, Stephen $491,768 University at Indianapolis Research and Quality
Cultural equivalence of autism assessment for University of Wisconsin - National Institutes Magana, Sandra $74,250 Latino children Madison of Health
Baby Siblings Research Consortium Staff Member Autism Speaks (AS) $45,000 Autism Speaks
Tager-Flusberg, Boston University $127,500 Autism Speaks Novel methods for testing language comprehension Helen in children with ASD This document is for discussion purposes only and does not reflect the decisions of the IACC
Tommerdahl, University of North Carolina National Institutes Sensory based CNS diagnostics for the clinic $218,946 Mark at Chapel Hill of Health
1.S.C Conduct at least three studies to identify reasons for the health disparities in accessing early screening and diagnosis services, including identification of barriers to implementation of and access to screening, diagnosis, referral, and early intervention services among diverse populations, as defined by socioeconomic status, race, ethnicity, and gender of the child, by 2012. IACC Recommended Budget: $2,000,000 over 2 years.
Project Title Principal Investigator Institution Funding Funder
Dissemination of multi-stage screening to Martinez-Pedraza, University of $28,000 Autism Speaks underserved culturally-diverse families Frances Massachusetts Boston
1.S.E
Conduct at least one study to determine the positive predictive value and clinical utility (e.g., prediction of co-occurring conditions, family planning) of chromosomal microarray genetic testing for detecting genetic diagnoses for ASD in a clinical setting by 2012. IACC Recommended Budget: $9,600,000 over 5 years.
Project Title Principal Investigator Institution Funding Funder
Gene dosage imbalance in neurodevelopmental National Institutes Ledbetter, David Emory University $690,019 disorders of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
1.L.A
Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014. IACC Recommended Budget: $33,300,000 over 5 years.
Project Title Principal Investigator Institution Funding Funder
Biomarkers for autism and for gastrointestinal and Anderson, Department of Yale University $0 sleep problems in autism George Defense-Army Visual attention and fine motor coordination in National Institutes Bhat, Anjana University of Connecticut $73,315 infants at risk for autism of Health
Early social and emotional development in toddlers National Institutes Campbell, Susan University of Pittsburgh $369,348 at genetic risk for autism of Health
ACE Center: Gaze perception abnormalities in Chawarska, National Institutes Yale University $293,130 infants with ASD Katarzyna of Health
Developmental characteristics of MRI diffusion National Institutes Conturo, Thomas Washington University $188,027 tensor pathway changes in autism of Health
ACE Center: MRI studies of early brain development University of California, San National Institutes Courchesne, Eric $349,341 in autism Diego of Health
Development of neural pathways in infants at risk for University of California, San National Institutes Dobkins, Karen $312,028 autism spectrum disorders Diego of Health
Are autism spectrum disorders associated with University of California, San National Institutes Dobkins, Karen $302,820 leaky-gut at an early critical period in development? Diego of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
The emergence of emotion regulation in children at- National Institutes Ekas, Naomi University of Miami $8,719 risk for autism spectrum disorder of Health
University of Texas Department of Serum antibody biomarkers for ASD German, Dwight $570,780 Southwestern Medical Center Defense-Army Hempstead, Misregulation of BDNF in autism spectrum disorders Weill Cornell Medical College $75,000 Simons Foundation Barbara
National Institutes
Early identification of autism: A prospective study Iverson, Jana University of Pittsburgh $481,734 of Health
Sensor-based technology in the study of motor skills National Institutes Iverson, Jana University of Pittsburgh $242,606 in infants at risk for ASD of Health
Massachusetts General Department of
Identification of lipid biomarkers for autism Kang, Jing $0 Hospital Defense-Army Physical and clinical infrastructure for research on Klin, Ami Emory University $0 Simons Foundation infants-at-risk for autism at Yale
The ontogeny of social visual engagement in infants National Institutes Klin, Ami Emory University $ 479,226 at risk for autism of Health
Brain-behavior growth charts of altered social Klin, Ami Yale University $208,333 Simons Foundation engagement in ASD infants Growth charts of altered social engagement in Klin, Ami Emory University $0 Simons Foundation infants with autism
National Institutes
ACE Center: Assessment Core Klin, Ami Yale University $541,624 of Health
ACE Center: Linguistic and social responses to National Institutes Kuhl, Patricia University of Washington $301,655 speech in infants at risk for autism of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
RNA expression studies in autism spectrum Kunkel, Louis Children's Hospital Boston $500,000 Simons Foundation disorders Signatures of gene expression in autism spectrum Kunkel, Louis Children's Hospital Boston $0 Simons Foundation disorders Department of Epigenetic biomarkers of autism in human placenta LaSalle, Janine University of California, Davis $576,142 Defense-Army Electrophysiological, metabolic and behavioral Nelson, Charles Children's Hospital Boston $395,734 Simons Foundation markers of infants at risk
National Institutes
Infants at risk of autism: A longitudinal study Ozonoff, Sally University of California, Davis $582,633 of Health
Temporal coordination of social communicative Parlade, University of Pittsburgh $0 Autism Speaks behaviors in infant siblings of children with autism Meaghan Physical and clinical infrastructure for research on Pelphrey, Kevin Yale University $219,581 Simons Foundation infants-at-risk for autism at Yale
Studying the biology and behavior of autism at 1- University of California, San National Institutes Pierce, Karen $272,245 year: The Well-Baby Check-Up approach Diego of Health
ACE Center: Clinical Phenotype: Recruitment and University of California, San National Institutes Pierce, Karen $310,430
Assessment Core Diego of Health
ACE Network: A longitudinal MRI study of infants at University of North Carolina National Institutes Piven, Joseph $3,246,479 risk for autism at Chapel Hill of Health
Supplement to NIH ACE Network grant: "A University of North Carolina Piven, Joseph $180,000 Simons Foundation longitudinal MRI study of infants at risk for autism" at Chapel Hill
This document is for discussion purposes only and does not reflect the decisions of the IACC
Placental vascular tree as biomarker of autism/ASD Research Foundation for Department of Salafia, Carolyn $0.00 risk Mental Hygiene, Inc. Defense-Army
ACE Center: Integrated Biostatistical and University of California, San National Institutes Schork, Nicholas $205,018
Bionformatic Analysis Core (IBBAC) Diego of Health
Neurophysiological investigation of language Seery, Anne Boston University $28,000.00 Autism Speaks acquisition in infants at risk for ASD
Southwestern Autism Southwest Autism Smith,
Family/Genetic study of autism Research & Resource Center $50,000 Research & Christopher (SARRC) Resource Center
Neurobehavioral research on infants at risk for SLI Tager-Flusberg, Boston University Medical National Institutes $671,693 and autism Helen Campus of Health
Neurobehavioral research on infants at risk for SLI Tager-Flusberg, Boston University Medical National Institutes $345,307 and autism (supplement) Helen Campus of Health
Predicting autism through behavioral and Tonnsen, National Institutes University of South Carolina $35,518 biomarkers of attention in infants Bridgette of Health
Dynamics of cortical interactions in autism spectrum Simmons Victor, Jonathan Cornell University $60,000 disorders Foundation
Multiplexed suspension arrays to investigate Centers for Disease Control Department of newborn and childhood blood samples for potential Vogt, Robert $0 and Prevention (CDC) Defense immune biomarkers of autism
Brain & Behavior Using near-infrared spectroscopy to measure the Wagner, Jennifer Harvard University $15,000 Research neural correlates of social and emotional Foundation This document is for discussion purposes only and does not reflect the decisions of the IACC
development in infants at risk for autism spectrum disorder
Abnormal vestibulo-ocular reflexes in autism: A Department of White, Keith University of Florida $0 potential endophenotype Defense Identifying gastrointestinal (GI) conditions in children Winter, Harland Harvard Medical School $0 Autism Speaks with autism spectrum disorders (ASD)
1.L.B
Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response, and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.
Project Title Principal Investigator Institution Funding Funder
A prospective multi-system evaluation of infants at Massachusetts General Department of Bauman, Margaret $0 risk for autism Hospital Defense-Army
University of North National Institutes Restricted repetitive behavior in autism Bodfish, James $377,158 Carolina at Chapel Hill of Health
Imitation in autism Bolton, Patrick King's College London $0 Autism Speaks
Neural mechanisms underlying obsessive National Institutes Carrasco, Melisa University of Michigan $31,987 compulsiveness in ASD of Health
Development of face processing in infants with Chawarska, National Institutes Yale University $409,613 autism spectrum disorders Katarzyna of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
ACE Center: Early detection and intervention in National Institutes Dawson, Geraldine University of Washington $614,004 infants at risk for autism of Health
Collaborative research: Computational behavioral National Science science: Modeling, analysis, and visualization of Dey, Anind Carnegie Mellon University $16,000 Foundation social and communicative behavior
New York University National Institutes
Translational developmental neuroscience of autism Di Martino, Adriana $164,718 School of Medicine of Health
Extraction of functional subnetworks in autism using National Institutes Duncan, James Yale University $353,349 multimodal MRI of Health
Collaborative research: Computational behavioral University of Illinois at National Science science: Modeling, analysis, and visualization of Forsyth, David $0 Urbana-Champaign Foundation social and communicative behavior
A prospective multi-system evaluation of infants at Massachusetts General Department of Herbert, Martha $0.00 risk for autism Hospital Defense-Army
Neural predictors of language acquisition after University of California, National Institutes Jeste, Shafali $181,207 intensive behavioral intervention Los Angeles of Health
California State University, National Institutes
Multiple social tasks and social adjustment Kang, Sun-Mee $143,550 Northridge of Health
Autism spectrum disorder in Down syndrome: A model of repetitive and stereotypic behavior for Kaufmann, Walter Kennedy Krieger Institute $0 Autism Speaks
idiopathic ASD
ACE Center: Eye-tracking studies of social National Institutes Klin, Ami Yale University $293,269 engagement of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
Perception of social and physical contingencies in National Institutes Klin, Ami Yale University $319,523 infants with ASD of Health
Autism: Social and communication predictors in National Institutes Landa, Rebecca Kennedy Krieger Institute $738,922 siblings of Health
University of California, National Institutes
Neuroimaging & symptom domains in autism Levitt, Jennifer $10,135 Los Angeles of Health
Using a direct observation assessment battery to MacDonald, New England Center for Organization for assess outcome of early intensive behavioral $10,000 Rebecca Children Autism Research intervention for children with autism
Magnetic source imaging and sensory behavioral University of California, National Institutes Marco, Elysa $176,229 characterization in autism San Francisco of Health
University of California, National Institutes
Cellular structure of the amygdala in autism Morgan, John $51,326 Davis of Health
Collaborative research: Computational behavioral Narayanan, University of Southern National Science science: Modeling, analysis, and visualization of $0 Shrikanth California Foundation social and communicative behavior
Functional brain networks in autism and attention Oregon Health & Science Nigg, Joel $149,841 Simons Foundation deficit hyperactivity disorder University
Analyses of brain structure and connectivity in University of California, National Institutes Nordahl, Christine $249,000 young children with autism Davis of Health
Collaborative research: Computational behavioral Massachusetts Institute of National Science science: Modeling, analysis, and visualization of Picard, Rosalind $0 Technology Foundation social and communicative behavior
This document is for discussion purposes only and does not reflect the decisions of the IACC
Collaborative research: Computational behavioral Georgia Tech Research National Science science: Modeling, analysis, and visualization of Rehg, James $24,000 Corporation Foundation social and communicative behavior
Washington University in National Institutes
The intersection of autism and ADHD Reiersen, Angela $161,293 St. Louis of Health
Electrophysiological signatures of language Children's Hospital of National Institutes Roberts, Timothy $344,521 impairment in autism spectrum disorder Philadelphia of Health
CDI-Type I: Understanding regulation of visual National Science attention in autism through computational and Scassellati, Brian Yale University $0 Foundation robotic modeling
Collaborative research: Computational behavioral Trustees of Boston National Science science: Modeling, analysis, and visualization of Sclaroff, Stan $0 University Foundation social and communicative behavior
Components of limited activity monitoring in toddlers National Institutes Shic, Frederick Yale University $82,750 with ASD of Health
ACE Center: The development of the siblings of University of California, National Institutes Sigman, Marian $309,408 children with autism: A longitudinal study Los Angeles of Health
Social-emotional development of infants at risk for National Institutes Stone, Wendy University of Washington $598,969 autism spectrum disorders of Health
Clinical and behavioral phenotyping of autism and National Institutes of National Institutes Swedo, Susan $2,117,811 related disorders Health of Health
University of Texas Family studies of sensorimotor and neurocognitive Department of Sweeney, John Southwestern Medical $0 heterogeneity in autism spectrum disorders (ASD) Defense Center at Dallas
This document is for discussion purposes only and does not reflect the decisions of the IACC
Electrophysiological correlates of cognitive control in University of California, National Institutes Takarae, Yukari $129,098 autism Davis of Health
Rutgers, The State A novel quantitative framework to study lack of National Science Torres, Elizabeth University of New Jersey - $0 social interactions in autism Foundation New Brunswick
HCC: Medium: Automatic detection of atypical Oregon Health & Science National Science Van Santen, Jan $0 patterns in cross-modal affect University Foundation
Identifying neurobiological markers of the broader Department of Wilson, Sarah University of Melbourne $106,245 autism phenotype Defense-Army
National Institutes
Social evaluation in infants and toddlers Wynn, Karen Yale University $409,613 of Health
National Institutes
Predicting useful speech in children with autism Yoder, Paul Vanderbilt University $607,697 of Health
Predicting useful speech in children with autism National Institutes Yoder, Paul Vanderbilt University $195,164 (supplement) of Health
1.L.C
Identify and develop measures to assess at least three "continuous dimensions" (e.g., social reciprocity, communication disorders, and repetitive/restrictive behaviors) of ASD symptoms and severity that can be used by practitioners and/or families to assess response to intervention for people with ASD across the lifespan by 2016. IACC Recommended Budget: $18,500,000 over 5 years.
Project Title Principal Investigator Institution Funding Funder
This document is for discussion purposes only and does not reflect the decisions of the IACC
National Institutes
The development of joint attention after infancy Adamson, Lauren Georgia State University $291,832 of Health
Development of intermodal perception of social Florida International National Institutes Bahrick, Lorraine $306,550 events: Infancy to childhood University of Health
Intersensory perception of social events: Typical and Florida International National Institutes Bahrick, Lorraine $134,355 atypical development University of Health
Innovative assessment methods for autism: A proof Connolly, John McMaster University $0 Autism Speaks of principle investigation of "nonverbal" autism Characterizing ASD phenotypes by multimedia Elhadad, Noemie Columbia University $339,498 Simons Foundation signal and natural language processing Receptive vocabulary knowledge in low-functioning Department of autism as assessed by eye movements, pupillary Gordon, Barry Johns Hopkins University $0 Defense-Army dilation, and event-related potentials
Developmental social neuroscience in infants at-risk McPartland, National Institutes Yale University $180,092 for autism James of Health
Brain & Behavior McPartland, Neural correlates of social perception in autism Yale University $15,000 Research James Foundation
Neural economics of biological substrates of Montague, P. National Institutes Baylor College of Medicine $379,913 valuation Read of Health
Language development and outcome in children National Institutes Naigles, Letitia University of Connecticut $311,574 with autism of Health
Language development and outcome in children National Institutes Naigles, Letitia University of Connecticut $88,096 with autism (supplement) of Health
This document is for discussion purposes only and does not reflect the decisions of the IACC
Sensory integration and language processing in National Institutes Silverman, Laura University of Rochester $149,435 autism of Health
Prosodic and pragmatic processes in highly verbal President & Fellows of Snedeker, Jesse $112,500 Simons Foundation children with autism Harvard College
Center for Autism Center for Autism and
The functions of stereotypy in children with ASD Tarbox, Jonathan $11,095 and Related Related Disorders (CARD) Disorders
Language learning in autism Ullman, Michael Georgetown University $31,500 Simons Foundation
1. Other
Not specific to any objective
Project Title Principal Investigator Institution Funding Funder
Social-affective bases of word learning in fragile X Abbeduto, University of Wisconsin - National Institutes $544,482 syndrome and autism Leonard Madison of Health
The development of selective attention in infancy as National Institutes Adler, Scott York University $53,376 measured by eye movements of Health
University of North Carolina National Institutes
Sensory experiences in children with autism Baranek, Grace $492,743 at Chapel Hill of Health
CAREER: Enabling community-scale modeling of Choudhury, National Science Cornell University $0 human behavior and its application to healthcare Tanzeem Foundation
Social and statistical mechanisms of prelinguistic Goldstein, National Science Cornell University $0 vocal development Michael Foundation
This document is for discussion purposes only and does not reflect the decisions of the IACC
Autism severity and muscle strength: A correlation University of Texas Autism Research Kern, Janet $4,920 analysis Southwestern Medical Center Institute
McPartland, National Institutes
Connectivity in social brain systems in autism Yale University $197,366 James of Health
INT2-Large: Collaborative research: Developing Messinger, National Science University of Miami $0 social robots Daniel Foundation
INT2-Large: Collaborative research: Developing University of California, San National Science Movellan, Javier $0 social robots Diego Foundation
Test of integrated language and literacy skills Department of Nelson, Nickola Western Michigan University $494,135 validation research Education
ACE Center: Auditory mechanisms of social National Institutes Paul, Rhea Yale University $263,206 engagement of Health
Visual processing and later cognitive effects in National Institutes Rivera, Susan University of California, Davis $237,070 infants with fragile X syndrome of Health
Online communication assessment to improve Oregon Health & Science Department of Rowland, Charity $0.00 outcomes for individuals with severe disabilities University Education Dissertation research: Translating diagnoses across National Science cultures: Expertise, autism, and therapeutics of the Sharp, Lesley Columbia University $14,510 Foundation self in Morocco Center for Autism Psychometric evaluation of the QABF in children Center for Autism and Wilke , Arthur $11,069 and Related with ASD Related Disorders (CARD) Disorders Atypical pupillary light reflex in individuals with Department of Yao, Gang University of Missouri $0.00 autism Defense-Army
This document is for discussion purposes only and does not reflect the decisions of the IACC