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Front Matter ANTICANCER RESEARCH International Journal of Cancer Research and Treatment ISSN: 0250-7005 Volume 36, Number 1, January 2016 Contents Reviews Using Epigenetic Therapy to Overcome Chemotherapy Resistance. J. STRAUSS, W.D. FIGG (Bethesda, MD, USA) ..................................................................................................................................... 1 Potential of Amifostine for Chemoradiotherapy and Radiotherapy-associated Toxicity Reduction in Advanced NSCLC: A Meta-Analysis. A. DEVINE, L. MARIGNOL (Dublin, Ireland) .......................................... 5 Factors Affecting Survival in Patients with Lung Metastases from Colorectal Cancer. A Short Meta-analysis. F. LUMACHI, G.B. CHIARA, R. TOZZOLI, A. DEL CONTEA, S.M.M. BASSO (Padova; Pordenone, Italy)..... 13 TAS-102 an Emerging Oral Fluoropyrimidine. J. CHEN, M. HAN, M.W. SAIF (St. Lucia; Wollongong, Australia; Boston, MA, USA)........................................................................................................... 21 Experimental Studies Inhibition of Chronic Pancreatitis and Murine Pancreatic Intraepithelial Neoplasia by a Dual Inhibitor of c- RAF and Soluble Epoxide Hydrolase in LSL-KrasG12D/Pdx-1-Cre Mice. J. LIAO, S.H. HWANG, H. LI, J.- Y. LIU, B.D. HAMMOCK, G.-Y. YANG (Chicago, IL; Davis, CA, USA)............................................. 27 HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage. Y. KAKU, A. TSUCHIYA, T. SHIMIZU, A. TANAKA, T. NISHIZAKI (Nishinomiya; Kobe, Japan) ......................................................................................................................................... 39 A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells. T.Y. ALHAZZAZI, P. KAMARAJAN, Y. XU, T. AI, L. CHEN, E. VERDIN, Y.L. KAPILA (Jeddah, Saudi Arabia; Ann Arbor, MI; Minneapolis, MN; San Francisco, CA, USA) .............. 49 Contents continued on the back cover ISSN (print): 0250-7005 ISSN (online): 1791-7530 Editorial Board Editorial Office: International Institute of Anticancer Research, 1st km Kapandritiou-Kalamou Rd., Kapandriti, P.O. Box 22, Attiki 19014, P. A. ABRAHAMSSON , Malm , Sweden Shant KUMAR, Manchester, UK ö Greece. Tel / Fax: +30-22950-53389. B. B. AGGARWAL, Houston, TX, USA O. D. LAERUM, Bergen, Norway U.S. Branch: Anticancer Research USA, Inc., 111 Bay Avenue, T. AKIMOTO, Kashiwa, Chiba, Japan F. J. LEJEUNE, Lausanne, Switzerland Highlands, NJ 07732, USA. P. Z. ANASTASIADIS, Jacksonville, FL, USA L. F. LIU, Piscataway, NJ, USA E-mails: Editorial Office: [email protected] A. ARGIRIS, San Antonio, TX, USA D. M. LOPEZ, Miami, FL, USA Managing Editor: [email protected] J. P. ARMAND, Toulouse, France E. LUNDGREN, Um ea, Sweden ANTICANCER RESEARCH supports: (a) the establishment and the ° activities of the INTERNATIONAL INSTITUTE OF ANTICANCER V. I. AVRAMIS, Los Angeles, CA, USA Y. MAEHARA, Fukuoka, Japan RESEARCH (IIAR; Kapandriti, Attiki, Greece); and (b) the organization R. C. BAST, Houston, TX, USA J. MAHER , London, UK of the International Conferences of Anticancer Research. The IIAR is a D.-T. BAU, Taichung, Taiwan, ROC J. MARESCAUX, Strasbourg, France member of UICC. For more information about ANTICANCER G. BAUER, Freiburg, Germany J. MARK, Sk vde, Sweden RESEARCH, IIAR and the Conferences, please visit the IIAR website: ö E. E. BAULIEU, Le Kremlin-Bicetre, France S. S. MARTIN, Baltimore, MD, USA www.iiar-anticancer.org ANTICANCER RESEARCH (AR) is published monthly E. J. BENZ , Jr., Boston, MA, USA S. MITRA, Houston, TX, USA Publication Data: from January 2009. Each annual volume comprises 12 issues. Annual J. BERGH, Stockholm, Sweden S. MIYAMOTO, Fukuoka, Japan Author and Subject Indices are included in the last issue of each volume. F. T. BOSMAN, Lausanne, Switzerland M. MUELLER, Villingen-Schwenningen, ANTICANCER RESEARCH Vol. 24 (2004) and onwards appears online G. BROICH, Monza, Italy Germany with Stanford University HighWire Press from April 2009. Ø. S. BRULAND, Oslo, Norway F. M. MUGGIA, New York, NY, USA Copyright: On publication of a manuscript in AR, which is a copyrighted publication, the legal ownership of all published parts of J. M. BUATTI, Iowa City, IA, USA M. NAMIKI, Kanazawa, Ishikawa, Japan the paper passes from the Author(s) to the Journal. M. M. BURGER, Basel, Switzerland R. NARAYANAN, Boca Raton, FL, USA Annual Subscription Rates 2016 per volume: Institutional subscription M. CARBONE, Honolulu, HI, USA K. NILSSON, Uppsala, Sweden US$ 1,898.00 (online) or US$ 2,277.00 (print & online). Personal C. CARLBERG, Kuopio, Finland S. 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ROSELLI, Rome, Italy Book Reviews: Recently published books and journals should be sent to the Editorial Office. Reviews will be published within 2-4 months. E. P. DIAMANDIS, Toronto, ON, Canada A. SCHAUER, G ttingen, Germany ö Articles in ANTICANCER RESEARCH are regularly indexed in all G. TH. DIAMANDOPOULOS, Boston, MA, USA M. SCHNEIDER, Wuppertal, Germany bibliographic services, including Current Contents (Life Sciences), Science D. W. FELSHER , Stanford, CA, USA A. SETH, Toronto, ON, Canada Citation Index, Index Medicus, Biological Abstracts, PubMed, Chemical J. A. FERNANDEZ-POL, Chesterfield, MO, USA G. V. SHERBET, Newcastle-upon-Tyne, UK Abstracts, Excerpta Medica, University of Sheffield Biomedical Information I. J. FIDLER, Houston, TX, USA G.-I. SOMA, Kagawa, Japan Service, Current Clinical Cancer, AIDS Abstracts, Elsevier Bibliographic Database, EMBASE, Compendex, GEOBASE, EMBiology, Elsevier BIOBASE, A. P. FIELDS, Jacksonville, FL, USA G. S. 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GIORDANO, Philadelphia, PA, USA B. WESTERMARK, Uppsala, Sweden Iberoamericana de Informaci ón Cient ífíca (SIIC) Data Bases. G. GITSCH, Freiburg, Germany Y. YEN, Duarte, CA, USA Authorization to photocopy items for internal or personal use, or the internal or personal clients, is granted by ANTICANCER RESEARCH, R. H. GOLDFARB, Saranac Lake, NY , USA M.R.I. YOUNG, Charleston, SC, USA provided that the base fee of $2.00 per copy, plus 0.40 per page is paid L. HELSON, Quakertown, PA, USA B. ZUMOFF, New York, NY, USA directly to the Copyright Clearance Center, 27 Congress Street, Salem, R. M. HOFFMAN, San Diego, CA, USA MA 01970, USA. For those organizations that have been granted a S. C. JHANWAR, New York, NY, USA photocopy license by CCC, a separate system of payment has been arranged. The fee code for users of the Transactional Reporting Service is J. V. JOHANNESSEN, Oslo, Norway J. G. DELINASIOS, Athens, Greece 0250-7005/2016 $2.00 +0.40. B. KAINA, Mainz, Germany Managing Editor The Editors and Publishers of ANTICANCER RESEARCH accept no P. -L. KELLOKUMPU-LEHTINEN, Tampere, responsibility for the opinions expressed by the contributors or for the Finland G. J. DELINASIOS, Athens, Greece content of advertisements appearing therein. , D. G. KIEBACK Marl, Germany Assistant Managing Editor and Copyright© 2016, Ιnternational Institute of Anticancer Research R. KLAPDOR, Hamburg, Germany Executive Publisher (Dr. John G. Delinasios), All rights reserved. S. D. KOTTARIDIS, Athens, Greece E. ILIADIS, Athens, Greece D.T.P. BY IIAR G. R. F. KRUEGER, K ln, Germany PRINTED BY ENTYPO, ATHENS, GREECE. PRINTED ON ACID-FREE PAPER ö Production Editor Pat M. KUMAR, Manchester, UK ANTICANCER RESEARCH International Journal of Cancer Research and Treatment ISSN (print): 0250-7005, ISSN (online): 1791-7530 VOLUME 36 2016 ANTICANCER RESEARCH 36: (2016) Editorial Board P.A. Abrahamsson Department of Urology, Skåne University Hospital, Lund University, Malmö, Sweden B. B. Aggarwal
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