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ANTICANCER RESEARCH International Journal of Cancer Research and Treatment ISSN: 0250-7005 Volume 37, Number 1, January 2017 Contents Reviews Clinical Implications of High-mobility Group Box-1 (HMGB1) and the Receptor for Advanced Glycation End-products (RAGE) in Cutaneous Malignancy: A Systematic Review. A.H. NGUYEN, S.Q. DETTY, D.K. AGRAWAL (Omaha, NE, USA) ............................................................................................................................. 1 Parenchymal-sparing Hepatectomy as the New Doctrine in the Treatment of Liver-metastatic Colorectal Disease: Beyond Oncological Outcomes. D. MORIS, D. DIMITROULIS, S. VERNADAKIS, A. PAPALAMPROS, E. SPARTALIS, A. PETROU, T.M. PAWLIK, E. FELEKOURAS (Cleveland; Columbus, OH, USA; Athens, Greece) ............................................................................................................................................................................ 9 Three Pathways of Colonic Carcinogenesis in Rats. C.A. RUBIO (Stockholm, Sweden) .................................. 15 Advances in Experimental Targeted Therapy and Immunotherapy for Patients with Glioblastoma Multiforme. J. POLIVKA JR, J. POLIVKA, L. HOLUBEC, T. KUBIKOVA, V. PRIBAN, O. HES, K. PIVOVARCIKOVA, I. TRESKOVA (Plzen, Czech Republic) ...................................................................................................................... 21 Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer. C. DAMASKOS, S. VALSAMI, M. KONTOS, E. SPARTALIS, T. KALAMPOKAS, E. KALAMPOKAS, A. ATHANASIOU, D. MORIS, A. DASKALOPOULOU, S. DAVAKIS, G. TSOUROUFLIS, K. KONTZOGLOU, D. PERREA, N. NIKITEAS, D. DIMITROULIS (Athens, Greece; Aberdeen, UK; Cleveland, OH, USA) ............................ 35 Experimental Studies KIF11 Is Required for Spheroid Formation by Oesophageal and Colorectal Cancer Cells. T. IMAI, N. OUE, K. SENTANI, N. SAKAMOTO, N. URAOKA, H. EGI, T. HINOI, H. OHDAN, K. YOSHIDA, W. YASUI (Hiroshima; Gifu; Kure, Japan) ............................................................................................................................. 47 Contents continued on the back cover ISSN (print): 0250-7005 ISSN (online): 1791-7530 Editorial Board Editorial Office: International Institute of Anticancer Research, 1st km Kapandritiou-Kalamou Rd., Kapandriti, P.O. Box 22, Attiki 19014, P. A. ABRAHAMSSON , Malm , Sweden Pat M. KUMAR, Manchester, UK ö Greece. Tel / Fax: +30-22950-53389. B. B. AGGARWAL, Houston, TX, USA Shant KUMAR, Manchester, UK U.S. Branch: Anticancer Research USA, Inc., 111 Bay Avenue, T. AKIMOTO, Kashiwa, Chiba, Japan O. D. LAERUM, Bergen, Norway Highlands, NJ 07732, USA. P. Z. ANASTASIADIS, Jacksonville, FL, USA F. J. LEJEUNE, Lausanne, Switzerland E-mails: Editorial Office: [email protected] A. ARGIRIS, San Antonio, TX, USA S. LINDER, Link ping, Sweden Managing Editor: [email protected] ö J. P. ARMAND, Toulouse, France L. F. LIU, Piscataway, NJ, USA ANTICANCER RESEARCH supports: (a) the establishment and the V. I. AVRAMIS, Los Angeles, CA, USA D. M. LOPEZ, Miami, FL, USA activities of the INTERNATIONAL INSTITUTE OF ANTICANCER D.-T. BAU, Taichung, Taiwan, ROC E. LUNDGREN, Um ea, Sweden RESEARCH (IIAR; Kapandriti, Attiki, Greece); and (b) the organization ° of the International Conferences of Anticancer Research. The IIAR is a G. BAUER, Freiburg, Germany Y. MAEHARA, Fukuoka, Japan member of UICC. For more information about ANTICANCER E. E. BAULIEU, Le Kremlin-Bicetre, France J. MAHER , London, UK RESEARCH, IIAR and the Conferences, please visit the IIAR website: E. J. BENZ , Jr., Boston, MA, USA J. 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