ANTICANCER RESEARCH International Journal of Cancer Research and Treatment ISSN: 0250-7005 Volume 36, Number 1, January 2016 Contents Reviews Using Epigenetic Therapy to Overcome Chemotherapy Resistance. J. STRAUSS, W.D. FIGG (Bethesda, MD, USA) ..................................................................................................................................... 1 Potential of Amifostine for Chemoradiotherapy and Radiotherapy-associated Toxicity Reduction in Advanced NSCLC: A Meta-Analysis. A. DEVINE, L. MARIGNOL (Dublin, Ireland) .......................................... 5 Factors Affecting Survival in Patients with Lung Metastases from Colorectal Cancer. A Short Meta-analysis. F. LUMACHI, G.B. CHIARA, R. TOZZOLI, A. DEL CONTEA, S.M.M. BASSO (Padova; Pordenone, Italy)..... 13 TAS-102 an Emerging Oral Fluoropyrimidine. J. CHEN, M. HAN, M.W. SAIF (St. Lucia; Wollongong, Australia; Boston, MA, USA)........................................................................................................... 21 Experimental Studies Inhibition of Chronic Pancreatitis and Murine Pancreatic Intraepithelial Neoplasia by a Dual Inhibitor of c- RAF and Soluble Epoxide Hydrolase in LSL-KrasG12D/Pdx-1-Cre Mice. J. LIAO, S.H. HWANG, H. LI, J.- Y. LIU, B.D. HAMMOCK, G.-Y. YANG (Chicago, IL; Davis, CA, USA)............................................. 27 HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage. Y. KAKU, A. TSUCHIYA, T. SHIMIZU, A. TANAKA, T. NISHIZAKI (Nishinomiya; Kobe, Japan) ......................................................................................................................................... 39 A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells. T.Y. ALHAZZAZI, P. KAMARAJAN, Y. XU, T. AI, L. CHEN, E. VERDIN, Y.L. KAPILA (Jeddah, Saudi Arabia; Ann Arbor, MI; Minneapolis, MN; San Francisco, CA, USA) .............. 49 Contents continued on the back cover ISSN (print): 0250-7005 ISSN (online): 1791-7530 Editorial Board Editorial Office: International Institute of Anticancer Research, 1st km Kapandritiou-Kalamou Rd., Kapandriti, P.O. Box 22, Attiki 19014, P. A. ABRAHAMSSON , Malm , Sweden Shant KUMAR, Manchester, UK ö Greece. Tel / Fax: +30-22950-53389. B. B. AGGARWAL, Houston, TX, USA O. D. LAERUM, Bergen, Norway U.S. Branch: Anticancer Research USA, Inc., 111 Bay Avenue, T. AKIMOTO, Kashiwa, Chiba, Japan F. J. LEJEUNE, Lausanne, Switzerland Highlands, NJ 07732, USA. P. Z. ANASTASIADIS, Jacksonville, FL, USA L. F. LIU, Piscataway, NJ, USA E-mails: Editorial Office: [email protected] A. ARGIRIS, San Antonio, TX, USA D. M. LOPEZ, Miami, FL, USA Managing Editor: [email protected] J. P. ARMAND, Toulouse, France E. 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KAINA, Mainz, Germany Managing Editor The Editors and Publishers of ANTICANCER RESEARCH accept no P. -L. KELLOKUMPU-LEHTINEN, Tampere, responsibility for the opinions expressed by the contributors or for the Finland G. J. DELINASIOS, Athens, Greece content of advertisements appearing therein. , D. G. KIEBACK Marl, Germany Assistant Managing Editor and Copyright© 2016, Ιnternational Institute of Anticancer Research R. KLAPDOR, Hamburg, Germany Executive Publisher (Dr. John G. Delinasios), All rights reserved. S. D. KOTTARIDIS, Athens, Greece E. ILIADIS, Athens, Greece D.T.P. BY IIAR G. R. F. KRUEGER, K ln, Germany PRINTED BY ENTYPO, ATHENS, GREECE. PRINTED ON ACID-FREE PAPER ö Production Editor Pat M. KUMAR, Manchester, UK ANTICANCER RESEARCH International Journal of Cancer Research and Treatment ISSN (print): 0250-7005, ISSN (online): 1791-7530 VOLUME 36 2016 ANTICANCER RESEARCH 36: (2016) Editorial Board P.A. Abrahamsson Department of Urology, Skåne University Hospital, Lund University, Malmö, Sweden B. B. Aggarwal