United States Patent (19) 11 Patent Number: 5,041,635 Narisada Et Al
United States Patent (19) 11 Patent Number: 5,041,635 Narisada et al. (45) Date of Patent: "Aug. 20, 1991 (54) 5(2)-7-(ENDO-3-BENZENESUL Jul. 17, 1986 (JP) Japan .............................. 61-1692.57 FONAMIDOBICYCLO(2.2.1]HEPT-EXO-2- 51) Int. Cl. ............................................ C07C311/20 YL)-5-HEPTENOIC ACID, SODIUM SALT 52 U.S. C. .................................................... 562/427 75) Inventors: Masayuki Narisada, Osaka; Mitsuaki 58) Field of Search ......................................... 562/427 Ohtani, Nara, both of Japan 73) Assignee: Shionogi & Co., Ltd., Osaka, Japan (56) References Cited U.S. PATENT DOCUMENTS *) Notice: The portion of the term of this patent subsequent to Aug. 29, 2006 has been 4,861,913 8/1989 Narisada et al. ...................... 549/23 disclaimed. OTHER PUBLICATIONS (21) Appl. No.: 541,491 Irwin, et al., J.A.C.S., pp. 8476-84.82 (1976), 98. 22 Filed: Jun. 20, 1990 Narisada et al., J. Med, Chem., 31(1988), pp. 1847-1854. Primary Examiner-Joseph P. Brust Related U.S. Application Data Attorney, Agent, or Firn-Wenderoth, Lind & Ponack 60 Continuation-in-part of Ser. No. 327,778, Mar. 23, 1989, which is a division of Ser. No. 927,823, Nov. 5, 57 ABSTRACT 1986, Pat. No. 4,861,913. There is provided 5(Z)-7-(endo-3-benzenesul (30) Foreign Application Priority Data fonamidobicyclo[2.2.1]hept-exo-2-yl)-5-heptenoic acid, Nov. 18, 1985 (JP) Japan ................................ 60-25915.4 sodium salt which is useful as an antithrombotic, anti Feb, l3, 1986 JP Japan .................................. 61-301.30 vasoconstricting and anti-bronchoconstricting agent. May 19, 1986 JP Japan ...............................
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