Orbital Osteoma
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Clinical Features of Benign Tumors of the External Auditory Canal According to Pathology
Central Annals of Otolaryngology and Rhinology Research Article *Corresponding author Jae-Jun Song, Department of Otorhinolaryngology – Head and Neck Surgery, Korea University College of Clinical Features of Benign Medicine, 148 Gurodong-ro, Guro-gu, Seoul, 152-703, South Korea, Tel: 82-2-2626-3191; Fax: 82-2-868-0475; Tumors of the External Auditory Email: Submitted: 31 March 2017 Accepted: 20 April 2017 Canal According to Pathology Published: 21 April 2017 ISSN: 2379-948X Jeong-Rok Kim, HwibinIm, Sung Won Chae, and Jae-Jun Song* Copyright Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College © 2017 Song et al. of Medicine, South Korea OPEN ACCESS Abstract Keywords Background and Objectives: Benign tumors of the external auditory canal (EAC) • External auditory canal are rare among head and neck tumors. The aim of this study was to analyze the clinical • Benign tumor features of patients who underwent surgery for an EAC mass confirmed as a benign • Surgical excision lesion. • Recurrence • Infection Methods: This retrospective study involved 53 patients with external auditory tumors who received surgical treatment at Korea University, Guro Hospital. Medical records and evaluations over a 10-year period were examined for clinical characteristics and pathologic diagnoses. Results: The most common pathologic diagnoses were nevus (40%), osteoma (13%), and cholesteatoma (13%). Among the five pathologic subgroups based on the origin organ of the tumor, the most prevalent pathologic subgroup was the skin lesion (47%), followed by the epithelial lesion (26%), and the bony lesion (13%). No significant differences were found in recurrence rate, recurrence duration, sex, or affected side between pathologic diagnoses. -
Bone and Soft Tissue Tumors Have Been Treated Separately
EPIDEMIOLOGY z Sarcomas are rare tumors compared to other BONE AND SOFT malignancies: 8,700 new sarcomas in 2001, with TISSUE TUMORS 4,400 deaths. z The incidence of sarcomas is around 3-4/100,000. z Slight male predominance (with some subtypes more common in women). z Majority of soft tissue tumors affect older adults, but important sub-groups occur predominantly or exclusively in children. z Incidence of benign soft tissue tumors not known, but Fabrizio Remotti MD probably outnumber malignant tumors 100:1. BONE AND SOFT TISSUE SOFT TISSUE TUMORS TUMORS z Traditionally bone and soft tissue tumors have been treated separately. z This separation will be maintained in the following presentation. z Soft tissue sarcomas will be treated first and the sarcomas of bone will follow. Nowhere in the picture….. DEFINITION Histological z Soft tissue pathology deals with tumors of the classification connective tissues. of soft tissue z The concept of soft tissue is understood broadly to tumors include non-osseous tumors of extremities, trunk wall, retroperitoneum and mediastinum, and head & neck. z Excluded (with a few exceptions) are organ specific tumors. 1 Histological ETIOLOGY classification of soft tissue tumors tumors z Oncogenic viruses introduce new genomic material in the cell, which encode for oncogenic proteins that disrupt the regulation of cellular proliferation. z Two DNA viruses have been linked to soft tissue sarcomas: – Human herpes virus 8 (HHV8) linked to Kaposi’s sarcoma – Epstein-Barr virus (EBV) linked to subtypes of leiomyosarcoma z In both instances the connection between viral infection and sarcoma is more common in immunosuppressed hosts. -
CASE REPORT Intradermal Nevus of the External Auditory Canal
Int. Adv. Otol. 2009; 5:(3) 401-403 CASE REPORT Intradermal Nevus of the External Auditory Canal: A Case Report Sedat Ozturkcan, Ali Ekber, Riza Dundar, Filiz Gulustan, Demet Etit, Huseyin Katilmis Department of Otorhinolaryngology and Head and Neck Surgery ‹zmir Atatürk Research and Training Hospital, Ministry of Health, ‹ZM‹R-TURKEY (SO, AE, FG, DE, HK) Department of Otorhinolaryngology and Head and Neck Surgery Etimesgut Military Hospital , ANKARA-TURKEY (RD) Intradermal nevus is the most common skin tumor in humans; however, its occurrence in the external auditory canal (EAC) is uncommon. The clinical manifestations of pigmented nevus of the EAC have been reported to include ear fullness, foreign body sensation, hearing impairment, and otalgia, but some cases were asymptomatic and were found incidentally. The treatment of choice for a symptomatic intradermal nevus in the EAC is complete excision. There has been no recurrence reported in the literature . A pedunculated, papillomatous hair-bearing lesion was detected in the external auditory canal of the patient who was on follow-up for pruritus. Clinical and pathologic features of an intradermal nevus of the external auditory canal are presented, and the literature reviewed. Submitted : 14 October 2008 Revised : 01 July 2009 Accepted : 09 July 2009 Intradermal nevus is the most common skin tumor in left external auditory canal. Otomicroscopic humans; however, its occurrence in the external examination revealed a pedunculated, papillomatous auditory canal (EAC) is uncommon [1-4]. Intradermal hair-bearing lesion in the postero-inferior cartilaginous nevus is considered to be a form of benign cutaneous portion of the external auditory canal (Figure 1). -
A Case of Intradermal Melanocytic Nevus with Ossification (Nevus of Nanta)
197 A Case of Intradermal Melanocytic Nevus with Ossification (Nevus of Nanta) Young Bok Lee, M.D., Kyung Ho Lee, M.D., Chul Jong Park, M.D. Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea A 49-year-old woman presented with a 30-year history of asymptomatic plaque on her right temple. The histological examination revealed nests of nevus cells throughout the entire dermis. Bony spicules were seen just beneath the nevus cell nests in the lower dermis. Cutaneous ossification is an unusual event. Herein, we present a case of intradermal melanocytic nevus with unusual ossification (nevus of Nanta). To the best of our knowledge, this is the first such case report in the Korean literature. (Ann Dermatol (Seoul) 20(4) 197∼199, 2008) Key Words: Melanocytic nevus, Ossification INTRODUCTION drug intake or medical illness. The histological examination showed a dense proliferation of benign Ossification within the skin may occur in a nevus cells in the upper dermis. They were arranged variety of conditions, including pilomatricoma, basal in nests surrounding the hair follicles (Fig. 2). Bony cell carcinoma, appendageal and fibrous prolifera- spicules were seen in the lower dermis, underneath 1,2 tion, inflammation and trauma . The occurrence of the nevus cell nests. Some of them were compact ossification within a melanocytic nevus is an un- while others were surrounded by mature fatty tissue 3-5 usual event . (Fig. 3). Herein, we present a case of intradermal melano- cytic nevus with unusual ossification (nevus of Nanta). To the best our knowledge, this is the first such case report in the Korean literature. -
Chondroblastoma-Like Extraskeletal Chondroma of The
Scholars Journal of Applied Medical Sciences (SJAMS) ISSN 2320-6691 (Online) Sch. J. App. Med. Sci., 2014; 2(4D):1428-1430 ISSN 2347-954X (Print) ©Scholars Academic and Scientific Publisher (An International Publisher for Academic and Scientific Resources) www.saspublisher.com Case Report Chondroblastoma-Like Extraskeletal Chondroma of the Hand: A Rare Case Report Navya BN1*, Ranganath N2, Karumbaiah P3, Kariappa TM4 1Assistant Professor, Department of Pathology, KVG Medical College and Hospital, Kurunjibag, Sullia-574327, India 2Assistant Professor, Department of Orthopaedics, KVG Medical College and Hospital, Kurunjibag, Sullia-574327, India 3Associate Prof , Department of Pathology , KVG Medical College and Hospital, Kurunjibag, Sullia-574327, India 4Professor & HOD, Department of Pathology, KVG Medical College and Hospital, Kurunjibag, Sullia-574327, India *Corresponding author Dr. Navya BN Email: Abstract: Extraskeletal chondroma (ESC) is a rare benign cartilaginous tumor that occurs predominantly in soft tissues near small joints of hand and feet. The importance of this lesion is that it must be distinguished from more aggressive soft tissue chondrosarcoma so as to spare the patient from unnecessary radical therapy. Here, we present a case of ESC of hand in a 32 yr old female with a variable histological appearance exhibiting chondroblastoma- like areas leading to a mistaken diagnosis of Extraskeletal myxoid chondrosarcomas (ESMCS). Hence, the case had to be carefully evaluated to exclude ESMCS and to make the diagnosis of ESC. The treatment was limited to simple excision of the tumor and extensive surgery and radiotherapy was avoided. Keywords: Extraskeletal chondroma, chondroblastoma- like areas, Extraskeletal myxoid chondrosarcomas. INTRODUCTION Extraskeletal chondroma (ESC ) also called as chondroma of soft parts is a relatively rare, benign, slow-growing soft tissue tumor composed mainly of hyaline cartilage with no connection to bone or periosteum. -
Chondroblastoma in Dog – a Rare Case
International Journal of Science and Research (IJSR) ISSN (Online): 2319-7064 Index Copernicus Value (2015): 78.96 | Impact Factor (2015): 6.391 Chondroblastoma in Dog – A Rare Case 1, 2 N. G. Amith B. N. Nagaraja Department of Surgery and Radiology, Veterinary College, Hebbal, Bangalore-24 1Veterinary Surgeon, Charlie’s animal Rescue Centre, Jakkur , Bangalore – 32, India 2Professors, Department of Veterinary Surgery and Radiology, KVAFSU, Veterinary College, Bangalore-24, India Abstract: Chondroblastoma (CB) is a rare benign chondral tumour characterised by an epiphyseal location in long bones. A four year old Rottweiler male dog was presented with the history of limping on right fore limb and swelling since two weeks as seen by owner. A plain radiograph showed a well-defined lytic defect, measuring 4-5 cm in diameter in the proximal epiphysis of the right ulnar region. The bone biopsy sample was collected and send for laboratory analysis for histopathology. Keywords: Chondroblastoma, dogs, long bone 1. Introduction Benign cartilage tumours of bone are the most common benign primary bone tumours and include osteochondroma, (en)chondroma, periosteal chondroma, chondroblastoma and chondromyxoid fibroma (Douis and Saifuddin, 2012). Chondroblastoma is a cancer composed of cells derived from transformed cells that produce cartilage and uncommon benign bone tumor arising from a secondary ossification center in the epiphyseal plates and apophyses. It is estimated to represent less than 1% of all primary bone tumours (Douis and Saifuddin, 2012). More than 75% of chondroblastoma lesions involve the long bones, and the most common anatomic sites are the epiphyseal and epimetaphyseal regions of the distal and proximal femur, proximal tibia, and proximal humerus (Turcotte et al.,1993) 2. -
Original Article Periosteal Chondroma of the Proximal Tibia: Report of Three Cases
Int J Clin Exp Med 2016;9(6):9908-9916 www.ijcem.com /ISSN:1940-5901/IJCEM0021012 Original Article Periosteal chondroma of the proximal tibia: report of three cases Zhenjiang Liu, Wei Yan, Lijun Zhang, Qiwei Li Department of Pediatric Orthopedics, Shengjing Hospital of China Medical University, Shenyang, People’s Repub- lic of China Received November 25, 2015; Accepted March 30, 2016; Epub June 15, 2016; Published June 30, 2016 Abstract: Periosteal chondroma is a relatively rare benign cartilaginous neoplasm usually seen in young adults. We presented three cases of periosteal chondroma in the proximal tibia of a 7-year-old girl (Case 1), a 12-year-old boy (Case 2) and a 15-year-8-month old boy (Case 3). Meticulous analysis of initial and follow-up plain radiographs, Computed Tomography (CT) and Magnetic resonance imaging (MRI) of these painless lesions suggested the diag- nosis of periosteal chondroma. This was confirmed by biopsy for Case 1 and Case 2. Local resection with curettage of the adjacent cortex and bone grafting were performed for Case 1 and Case 2. No biopsy or treatment was per- formed for Case 3. Recovery was uneventful in all three cases. There was no recurrence at the three years and eight months (Case 1), six months (Case 2), and seven years and one month (Case 3) follow-ups. Keywords: Periosteal chondroma, tibia Introduction in the proximal tibia of a 7-year-old girl, a 12-year-old boy and a 15-year-8-month old boy, Periosteal (juxtacortical) chondroma is a slow with a review of the relevant literature. -
Basal Cell Carcinoma Associated with Non-Neoplastic Cutaneous Conditions: a Comprehensive Review
Volume 27 Number 2| February 2021 Dermatology Online Journal || Review 27(2):1 Basal cell carcinoma associated with non-neoplastic cutaneous conditions: a comprehensive review Philip R Cohen MD1,2 Affiliations: 1San Diego Family Dermatology, National City, California, USA, 2Touro University California College of Osteopathic Medicine, Vallejo, California, USA Corresponding Author: Philip R Cohen, 10991 Twinleaf Court, San Diego, CA 92131-3643, Email: [email protected] pathogenesis of BCC is associated with the Abstract hedgehog signaling pathway and mutations in the Basal cell carcinoma (BCC) can be a component of a patched homologue 1 (PCTH-1) transmembrane collision tumor in which the skin cancer is present at tumor-suppressing protein [2-4]. Several potential the same cutaneous site as either a benign tumor or risk factors influence the development of BCC a malignant neoplasm. However, BCC can also concurrently occur at the same skin location as a non- including exposure to ultraviolet radiation, genetic neoplastic cutaneous condition. These include predisposition, genodermatoses, immunosuppression, autoimmune diseases (vitiligo), cutaneous disorders and trauma [5]. (Darier disease), dermal conditions (granuloma Basal cell carcinoma usually presents as an isolated faciale), dermal depositions (amyloid, calcinosis cutis, cutaneous focal mucinosis, osteoma cutis, and tumor on sun-exposed skin [6-9]. However, they can tattoo), dermatitis, miscellaneous conditions occur as collision tumors—referred to as BCC- (rhinophyma, sarcoidal reaction, and varicose veins), associated multiple skin neoplasms at one site scars, surgical sites, systemic diseases (sarcoidosis), (MUSK IN A NEST)—in which either a benign and/or systemic infections (leischmaniasis, leprosy and malignant neoplasm is associated with the BCC at lupus vulgaris), and ulcers. -
Osteoid Osteoma and Your Everyday Practice
n Review Article Instructions 1. Review the stated learning objectives at the beginning cme ARTICLE of the CME article and determine if these objectives match your individual learning needs. 2. Read the article carefully. Do not neglect the tables and other illustrative materials, as they have been selected to enhance your knowledge and understanding. 3. The following quiz questions have been designed to provide a useful link between the CME article in the issue Osteoid Osteoma and your everyday practice. Read each question, choose the correct answer, and record your answer on the CME Registration Form at the end of the quiz. Petros J. Boscainos, MD, FRCSEd; Gerard R. Cousins, MBChB, BSc(MedSci), MRCS; 4. Type or print your full name and address and your date of birth in the space provided on the CME Registration Form. Rajiv Kulshreshtha, MBBS, MRCS; T. Barry Oliver, MBChB, MRCP, FRCR; 5. Indicate the total time spent on the activity (reading article and completing quiz). Forms and quizzes cannot be Panayiotis J. Papagelopoulos, MD, DSc processed if this section is incomplete. All participants are required by the accreditation agency to attest to the time spent completing the activity. educational objectives 6. Complete the Evaluation portion of the CME Regi stration Form. Forms and quizzes cannot be processed if the Evaluation As a result of reading this article, physicians should be able to: portion is incomplete. The Evaluation portion of the CME Registration Form will be separated from the quiz upon receipt at ORTHOPEDICS. Your evaluation of this activity will in no way affect educational1. -
Basal Cell Carcinoma with Osteoma Cutis
Open Access Case Report DOI: 10.7759/cureus.3170 Basal Cell Carcinoma with Osteoma Cutis Stella X. Chen 1 , Philip R. Cohen 2 1. School of Medicine, University of California, San Diego 2. Dermatologist, San Diego Family Dermatology, San Diego, USA Corresponding author: Stella X. Chen, [email protected] Abstract Osteoma cutis is the formation of bone within the skin. It can present as either primary osteoma cutis or secondary osteoma cutis. Secondary osteoma cutis is more common and is associated with inflammatory, infectious, and neoplastic disorders, including basal cell carcinoma. A 79-year-old Caucasian man without underlying kidney disease or calcium abnormalities presented with a basal cell carcinoma with osteoma cutis on the chin. Basal cell carcinoma with osteoma cutis has seldom been described; however, the occurrence of this phenomenon may be more common than suggested by the currently published literature. The preferred treatment is surgical excision—with or without using Mohs micrographic technique. When the histopathologic examination reveals bone formation in the skin, clinicians should consider the possible presence of an adjacent malignancy, such as a basal cell carcinoma. Categories: Dermatology, Oncology Keywords: basal, bone, calcium, calcinosis, carcinoma, cell, cutis, ossification, osteoma Introduction Basal cell carcinoma is the most common type of skin cancer. Osteoma cutis is the formation of bone within the skin; it can occur either as a distinct cutaneous entity or associated with other conditions. In primary osteoma cutis, idiopathic ossification occurs and can be congenital, acquired, or related to Albright’s hereditary osteodystrophy and fibrodysplasia ossificans progressiva. Secondary osteoma cutis is more commonly seen and may be associated with infectious, inflammatory, or neoplastic disorders, including basal cell carcinoma. -
Craniofacial Chondrosarcomas: Imaging Findings in 15 Untreated Cases
165 Craniofacial Chondrosarcomas: Imaging Findings in 15 Untreated Cases Ya-Yen Lee1 Radiographic findings of 15 untreated chondrosarcomas of the cranial and facial Pamela Van Tassel bones were reviewed. These tumors have a propensity to occur in the wall of a maxillary sinus, at the junction of sphenoid and ethmoid sinuses and vomer, and at the undersur face of the sphenoid bone. Because of its slow-growing nature, chondrosarcomas tend to be large, multi lobulated, and sharply demarcated when detected. Frequent bone changes are a combination of erosion and destruction, with sharp transitional zones and absent periosteal reaction. Tumor matrix calcifications, not necessarily chondroid, are almost always present. Both CT and MR may be necessary for thorough evaluation of tumor extent. Chondrosarcoma, a malignant but usually slow-growing cartilaginous tumor, constitutes approximately 11 % of malignant bone tumors [1] but rarely occurs in the craniofacial region . Because of its propensity to occur in the deep facial structures or base of the skull, the true extent and origin of the tumor may be overlooked if not properly evaluated radiographically. We review a relatively large series of craniofacial chondrosarcomas and discuss the differential diagnosis and choice of imaging technique. Materials and Methods This retrospective radiologic review was based on the pretreatment radiographic studies of 15 patients with craniofacial chondrosarcomas seen at our institution over a period of 40 years , excluding three intracranial dural chondrosarcomas, which are to be reported sepa rately. An attempt was also made to correlate the radiographic findings with the hi stologic grades of the tumors. The ages of the patients ranged from 10 to 73 years , with a mean of 40 years. -
Things That Go Bump in the Light. the Differential Diagnosis of Posterior
Eye (2002) 16, 325–346 2002 Nature Publishing Group All rights reserved 0950-222X/02 $25.00 www.nature.com/eye IG Rennie Things that go bump THE DUKE ELDER LECTURE 2001 in the light. The differential diagnosis of posterior uveal melanomas Eye (2002) 16, 325–346. doi:10.1038/ The list of lesions that may simulate a sj.eye.6700117 malignant melanoma is extensive; Shields et al4 in a study of 400 patients referred to their service with a pseudomelanoma found these to encompass 40 different conditions at final diagnosis. Naturally, some lesions are Introduction mistaken for melanomas more frequently than The role of the ocular oncologist is two-fold: others. In this study over one quarter of the he must establish the correct diagnosis and patients referred with a diagnosis of a then institute the appropriate therapy, if presumed melanoma were subsequently found required. Prior to the establishment of ocular to have a suspicious naevus. We have recently oncology as a speciality in its own right, the examined the records of patients referred to majority of patients with a uveal melanoma the ocular oncology service in Sheffield with were treated by enucleation. It was recognised the diagnosis of a malignant melanoma. that inaccuracies in diagnosis occurred, but Patients with iris lesions or where the the frequency of these errors was not fully diagnosis of a melanoma was not mentioned appreciated until 1964 when Ferry studied a in the referral letter were excluded. During series of 7877 enucleation specimens. He the period 1985–1999 1154 patients were found that out of 529 eyes clinically diagnosed referred with a presumed melanoma and of as containing a melanoma, 100 harboured a these the diagnosis was confirmed in 936 lesion other than a malignant melanoma.1 cases (81%).