Rapport Annuel 2012 INSTITUT DU CERVEAU ET DE LA MOELLE

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Rapport Annuel 2012 INSTITUT DU CERVEAU ET DE LA MOELLE INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE Rapport annuel 2012 CHERCHER, TROUVER, GUÉRIR, POUR VOUS & AVEC VOUS. 1 ICM Rapport Annuel 2012 Rapport annuel 2012 Le mot du Président.................................................................................................3 Le mot du Directeur Général .............................................................................5 L’ICM : un centre d’excellence ..........................................................................7 Qu’est-ce que l’ICM ? ........................................................................................................ p.8 Quelques dates clés ...........................................................................................................p.9 L’o r g a n i s a t i o n ..................................................................................................................... p.10 L’IHU A-ICM ..........................................................................................................................p.12 L’e x c e l l e n c e .......................................................................................................................... p.14 Les faits marquants de la recherche en 2012 .................................... 19 Les maladies neurodégénératives ......................................................................... p.20 La sclérose en plaques et la réparation myélinique ...................................... p.24 dans le système nerveux central et périphérique Les tumeurs cérébrales................................................................................................ p.26 L’activité électrique du cerveau . p.27 Cognition et comportement ......................................................................................p.29 Référence des publications .......................................................................................p.33 L’organisation de la recherche .....................................................................35 Les axes de recherche ...................................................................................................p.36 Les équipes.......................................................................................................................... p.37 Le Centre d’Investigation Clinique ........................................................................... p.60 Les plateformes technologiques .............................................................................. p.62 Les applications de la recherche ................................................................ 73 Les entreprises à l’ICM, le rôle d’incubateur ..................................................... p.74 Les faits marquants en 2012....................................................................................... p.76 L’animation scientifique et « extrascientifique » ..............................79 La communication .................................................................................................. 83 La nouvelle campagne de communication .........................................................p.84 Les événements sportifs et culturels.....................................................................p.85 Opérations Produit-Partage........................................................................................p.86 Les Matinées ICM .............................................................................................................p.86 Les newsletters ................................................................................................................. p.87 Le rapport financier..............................................................................................89 La collecte............................................................................................................................p.91 Le compte emplois-ressources ................................................................................p.92 Bilan et analyses ............................................................................................................... p.94 Les membres fondateurs, Conseils et Comités .................................. 97 La gouvernance .................................................................................................................p.98 Le Comité de Campagne ............................................................................................. p.100 Les grands donateurs ..................................................................................................p.101 L’équipe .............................................................................................................................. p.102 Les publications .................................................................................................. 103 FONDATION INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE Hôpital Pitié-Salpêtrière - 47, boulevard de l’Hôpital - 75013 Paris – France Tél. : +33 (0) 1 57 27 40 00 - Fax : +33 (0) 1 57 27 40 27 icm-institute.org SOMMAIRE Le mot du Président 2012 est la deuxième année d’existence de l’ICM mais correspond en fait à la première année de plein exercice de la fondation, permettant ainsi à près de 500 chercheurs d’exprimer tout leur potentiel… Cette année a été marquée par deux éléments forts : Le renforcement des moyens déjà existants, en particulier, humains, afin de permettre une efficacité maximum : création et mise en oeuvre de l’institut hospitalo-universitaire IHU-A-ICM, nomination par le Conseil d’administration de l’ICM, du Pr. Alexis Brice, éminent scientifique, au poste de directeur général, visite du comité scientifique international dont les conseils en termes d’organisation et de stratégie scien- tifique ont été précieux, accueil de 9 entreprises dans la pépinière ICM. Des résultats scientifiques de grande valeur et très prometteurs comme en attestent le nombre de publica- tions, leur évaluation (impact factor) par la communauté scientifique internationale, sans parler, des nombreux prix, récompenses et distinctions dont ont bénéficié un grand nombre de chercheurs en reconnaissance de leurs travaux et découvertes. Ceci ne fait que renforcer, s’il en était besoin, notre volonté d’excellence qui doit faire de l’ICM un centre de référence mondiale et le placer dans le top 5 mondial et le premier européen à court terme. Cette reconnais- sance n’est pas un but en soi mais viendra cautionner la stratégie définie pour gagner le formidable défi que tous, membres fondateurs, conseil d’administration, chercheurs, partenaires, donateurs, nous nous sommes fixés : prévenir, guérir et réparer les maladies et atteintes neurologiques, quelle qu’en soit leur origine. C’est pourquoi 2013 sera l’année de révision des objectifs scientifiques et thérapeutiques pour les 5 ans à venir. Cette stratégie n’a qu’un but : grâce à la politique de recherche translationnelle de l’ICM, trouver une solution thérapeutique pratique pour le malade à court terme. Nous ne devons pas faire rêver à tort et donner de faux espoirs, mais transformer l’impossible en possible grâce aux talents, au dynamisme et à l’enthousiasme extraordinaire de nos chercheurs. Ces objectifs seront également atteints grâce à chacun d’entre nous par le soutien et l’aide que nous leur apportons et je tiens ici à vous remercier tous, institutions, entreprises, donateurs anonymes ou célèbres, qui apportez votre contribution généreuse, efficace et fidèle. Votre appartenance à l’ICM est forte et indispensable et nous nous devons de Réussir. Professeur Gérard Saillant Président ICM Rapport Annuel 2012 3 SOMMAIRE 4 ICM Rapport Annuel 2012 Le mot du Directeur Général La première année de fonctionnement à plein régime de l’ICM vient de s’achever et les résultats scientifiques sont déjà au rendez-vous. Le chapitre « faits marquants » résume les nombreuses avancées médicales et scientifiques à porter au crédit du nouvel Institut. Cette dynamique a été renforcée par le démarrage en cours d’année de l’IHU-A-ICM, un des 6 Instituts Hospitalo-Universitaires créés dans le cadre des investissements d’avenir, qui vient épauler les recherches de l’ICM. Avec Bertrand Fontaine qui dirige l’IHU-A-ICM, nous conduisons une politique de convergence des objectifs scientifiques pour que nos équipes bénéficient de toutes les synergies entre l’ICM et l’IHU-A-ICM. Ainsi, l’IHU-A-ICM contribue déjà à renforcer les plateaux technologiques de l’Institut (imagerie du cerveau et de la moelle, électrophysiologie, stimulation magnétique, etc), les projets de recherche et les cohortes de patients. La visite de notre conseil scientifique international en avril 2012 a été très fructueuse. Les conseils prodigués nous ont permis de renforcer nos actions envers les étudiants et les chercheurs post-doctorants ainsi que de développer les interactions entre chercheurs d’équipes différentes pour faire naître des projets pluridisci- plinaires et ambitieux. Ils ont également conduit à affiner notre projet scientifique évalué en janvier 2013 par l’agence nationale chargée de l’évaluation de la recherche (AERES). Notre conseil scientifique international sera à nouveau mobilisé en 2013, pour évaluer les candidatures reçues, en réponse à l’appel qui sera lancé au premier semestre 2013 conjointement avec l’IHU-A-ICM. Nous pourrons ainsi renforcer nos axes scientifiques grâce au recrutement de jeunes talents internationaux. L’animation scientifique est très active avec plus d’une centaine de conférences données par des chercheurs prestigieux. La conférence du Lauréat
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