Int. J. Biol. Sci. 2021, Vol. 17 498 Ivyspring International Publisher International Journal of Biological Sciences 2021; 17(2): 498-513. doi: 10.7150/ijbs.55636 Research Paper DGCR5 is activated by PAX5 and promotes pancreatic cancer via targeting miR-3163/TOP2A and activating Wnt/β-catenin pathway Shi-lei Liu1,2*, Chen Cai1,2*, Zi-yi Yang1,2*, Zi-you Wu1, Xiang-song Wu1,2, Xue-feng Wang1,2, Ping Dong1,2, Wei Gong1,2 1. Department of General Surgery, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China 2. Shanghai Key Laboratory of Biliary Tract Disease Research, No. 1665 Kongjiang Road, Shanghai 200092, China *These authors contributed equally to this work. Corresponding authors: Ping Dong, Department of General Surgery, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, No.1665 Kongjiang Road, Shanghai 200092, China. Tel/Fax: +86-21-25077875; E-mail:
[email protected]. Wei Gong, Department of General Surgery, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, No.1665 Kongjiang Road, Shanghai 200092, China. Tel/Fax: +86-21-25077885; E-mail:
[email protected] © The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. Received: 2020.11.08; Accepted: 2020.12.22; Published: 2021.01.01 Abstract Long noncoding RNA DiGeorge syndrome critical region gene 5 (DGCR5) has been shown to be highly associated with cancer development.