molecules Article Iridoids and Amino Acid Derivatives from the Paraguayan Crude Drug Adenocalymma marginatum (ysypó hû) Guillermo Schmeda-Hirschmann 1,* , Alberto Burgos-Edwards 1, Felipe Jiménez-Aspee 2 , Daniel Mieres-Castro 1, Cristina Theoduloz 3, Lisa Pormetter 1, Ramon Fogel 4, Claudia Céspedes 4 , Nelida Soria 4 and Sintya Valdez 4 1 Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Campus Lircay, Talca 3460000, Chile;
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[email protected] (L.P.) 2 Departamento de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Universidad de Talca, Campus Lircay, Talca 3460000, Chile;
[email protected] 3 Laboratorio de Cultivo Celular, Facultad de Ciencias de la Salud, Universidad de Talca, Campus Lircay, Talca 3460000, Chile;
[email protected] 4 Centro de Estudios Rurales Interdisciplinarios, Oliva 1019, Edificio Lider V, Piso 17, oficina 172, Asunción 01421, Paraguay;
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[email protected] (S.V.) * Correspondence:
[email protected]; Tel.: +56-712-200-288 Received: 5 December 2019; Accepted: 27 December 2019; Published: 1 January 2020 Abstract: The crude drug ysypó hû (Adenocalymma marginatum DC., Bignoniaceae) is used traditionally by the Guarani of Eastern Paraguayan as a male sexual enhancer. The aim of the present study was to identify the main constituents of the crude drug and to evaluate the in vitro inhibitory activity towards the enzyme phosphodiesterase-5 (PDE-5). The main compounds were isolated by counter-current chromatography (CCC).