Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_004758865Cyc: Acinetobacter baumannii CIAT758 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

ammonium ammonium

RS15655 RS00960

ammonium ammonium

Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Amine and Polyamine Degradation Aldehyde Degradation Fermentation mixed acid fermentation a DNA containing a nascent a [glutamine 2445 (3R,5S)-3- [2Fe-2S] iron-sulfur a purine a [glutamine- succinyl-CoA a 3-oxo acid a guanine L(or D)-O- an L-glutamyl- superpathway of tetrahydrofolate biosynthesis ubiquinol-8 biosynthesis glutathione bis(guanylyl molybdenum 5-methylbenzimidazolyl ethanolamine utilization methylglyoxal degradation I an apurinic/ peptidoglycan synthetase]-O met hydroxy-1- cluster biosynthesis flavin biosynthesis I (bacteria and plants) 4-aminobutanoate 4-aminobutanoate synthetase]- ATP in 23S rRNA phosphoserine [tRNA Gln ] phosphoenolpyruvate L-carnitine degradation III ribonucleoside adenosylcobinamide 4 superpathway of adenosylcobalamin salvage from cobinamide I (prokaryotic) biosynthesis cofactor) biosynthesis adenosylcobamide biosynthesis Aminoacyl-tRNA Charging degradation I apyrimidinic site (meso-DAP -(5'-adenylyl) 3-oxoacid CoA- bifunctional phosphoserine bifunctional pyrroline-5- degradation III 5'-triphosphate endonuclease lytic murein L-tyrosine bifunctional [glutamate- L-asparaginase/ all-trans- MoO - from adenosylcobinamide-GDP ethanolamine methylglyoxal bifunctional III: nth containing) -L-tyrosine bifunctional [glutamate- transferase: 23S rRNA phosphatase Glu-tRNAGln glutamate N- carboxylatepyrroline-5- L-cysteine desulfurase 2 allantoin degradation transglycosylase: -ammonia ligase]- GTP 4-hydroxybenzoate octaprenyl molybdopterin tRNA charging 4-aminobutanoate L-carnitine lactoylglutathione adenosylcobinamide -ammonia ligase]- E4664_RS09425 (guanine(2069)-N(7) SerB: serB acetyltransferase/ carboxylate GTP cob(II)inamide cys glu 5-methylbenzimidazole NaMN glutaminyl-tRNA gln to glyoxylate I 4-aminobutanoate bifunctional DNA- E4664_RS16775 adenylyl-L-tyrosine amidotransferase 4-hydroxybenzoatediphosphate cofactor ethanolamine 4-aminobutyrate- lyase: gloA kinase/ adenylyl-L-tyrosine E4664_RS09430 )-methyltransferase amino-acid reductase: cysteine glutamate-- nicotinate-nucleotide-- biosynthesis via transamidation 4-aminobutyrate- formamidopyrimidine a mature phosphorylase/ bifunctional subunit D: cob(I)yrinic acid octaprenyltransferase: ammonia-lyase: -2-oxoglutarate (R)-S- adenosylcobinamide- [+ 3 isozymes] phosphorylase/ 3-oxoacid CoA- RlmK/23S rRNA acetyltransferase E4664_RS10305 desulfurase: bifunctional GTP cysteine ligase: dimethylbenzimidazole arginine-- (S)-(+)-allantoin -2-oxoglutarate glycosylase/ peptidoglycan [glutamate-- phosphoserine E4664_RS14630 a,c-diamide E4664_RS02790 bis(molybdenum arg oxaloacetate pyruvate E4664_RS05205 transaminase: lactoylglutathione phosphate a nascent [glutamate-- transferase (guanine(2445)-N(2) E4664_RS09185 3,4-dihydroxy- cyclohydrolase 3-octaprenyl-4- γ E4664_RS17505 phosphoribosyltransferase: tRNA ligase: transaminase: phosphatase/ ArgJ: argJ pyrroline-5- -L-glutamyl- glu E4664_RS05210 allantoinase guanylyltransferase: DNA-(apurinic with (L-alanyl- ammonia-ligase] ammonia-ligase] )-methyltransferase Asp-tRNA(Asn) 2-butanone- I FolE: folE adenosyltransferase: hydroxybenzoate cofactor) cobT E4664_RS16090 an L-arginyl- succinategabT gabT hydroxyacylglutathione γ peptidoglycan subunit A: homoserine amino-acid N- carboxylate an S-sulfanyl-[L- L-cysteine 5-methylbenzimidazole L-malic PuuE: puuE succinate cobU or apyrimidinic -D-glutamyl- adenylyltransferase: adenylyltransferase: RlmL: rlmKL /Glu-tRNA(Gln) 7,8- E4664_RS00260 molybdenum cofactor Arg trimethylamine hydrolase: gloB a purine adenosyl- (meso-DAP E4664_RS06375 2 phosphotransferase reductase: 4-phosphate glutathione [tRNA ] NAD-dependent D-lactate acetaldehyde semialdehyde semialdehyde semialdehyde site) lyase: mutM meso-2,6- a [glutamine glnE an N - amidotransferase: acetyltransferase: cysteine desulfurase] dihydroneopterin [corrinoid ribotide phosphate Arg allantoate containing) with a [glutamine-glnE a 2,3,4-saturated synthase/GTP guanylyltransferase: a tRNA malic enzyme: dehydrogenase: ribonucleoside cobinamide a 5'-phospho- a 3'-terminal succinate methylguanine 2445 ThrH: thrH E4664_RS16620 E4664_RS13690 adenosyltranferase]- synthase: NAD-dependent diaminopimeloyl- synthetase]-O 3-oxoacyl-CoA gatB gatA gatC 3'-triphosphate E4664_RS05760 adenosylcobinamide- (R)-lactate 5'-diphosphate phosphate [DNA] unsaturated sugar GlcNAc terminus ADP synthetase]- 4 an L-glutaminyl- N-acetyl-L- Hyp cyclohydrolase II: gshB E4664_RS16085 E4664_RS16375 succinate- allantoicase: D-alanine) -(5'-adenylyl) in 23S rRNA serine cob(II)inamide bis(guanylyl NAD(P)- L-tyrosine Gln E4664_RS17405 GDP tetrapeptide -L-tyrosine [tRNA ] methionine 2-octaprenylphenol molybdopterin) an L-glutamyl- acetyl-CoA formate dependent alcohol semialdehyde E4664_RS17605 glutathione ribazoletransferase: Gln an S-sulfanyl-[cysteine GTP cofactor [tRNA ] (S)-malate (R)-lactate dehydrogenase: dehydrogenase: (S)-malate succinate desulfurase]-[disordered- 7,8- E4664_RS07680 acetyl-CoA (S)-ureidoglycolate cyclohydrolase α α cysteine-- citrate (Si)- E4664_RS12760 6 1498 [corrinoid Co -[ -(5-methylbenzimidazolyl) cys L-asparaginase/ phosphate E4664_RS17120 undecaprenyl- an O - L-alanyl-γ-D- 2069 a uracil (S)-1-pyrroline- 4-methyl-3- form scaffold II: ribA dihydroneopterin tRNA ligase: fumarate hydratase: synthase: gltA NAD-dependent pyruvate a [protein]- succinyl-CoA acetoacetate a ribonucleoside a guanine a quinone ]-Coβ-adenosylcobamide Glu-tRNAGln NAD-dependent diphospho-N- methylguanine UDP-N-acetyl- glutamyl-meso-2,6- oxoadipate- protein] complex 2,5-diamino-6- 3'-phosphate adenosyltranferase]- 3-(all-trans E4664_RS14340 acetyltransferase: phosphate malic enzyme: ureidoglycolate L-cysteine ATP H O 5'-monophosphate in 23S rRNA in 16S rRNA 5-carboxylate 5'-phosphate E4664_RS10235 an L-cysteinyl- succinate- in DNA α-D-muramate 2 3-oxoacid CoA- 16S rRNA trifunctional NADPH-quinone enol-lactone (5-phospho-D- cob(I)inamide -octaprenyl) amidotransferase E4664_RS14335 CO H acetyltransferase: ethanol E4664_RS16085 lyase: acetylmuramoyl- UDP-N-acetyl- methylated-DNA-- diaminopimeloyl- 5'-nucleotidase bifunctional Cys class II fumarate citrate 2 2 type I secretion 3-oxoadipate [tRNA ] subunit D: acetaldehyde semialdehyde E4664_RS17600 L-alanyl-γ-D- α-D-glucosamine UDP-N-D-alanine transferase: 23S rRNA (uracil(1498)-N(3))- transcriptional reductase ribosylamino) cob(I)yrinic acid benzene-1,2-diol Cys E4664_RS14335 [protein]-cysteine S- SurE: a tRNA hydratase: fumC dehydrogenase: putrescine degradation I undecaprenyldiphospho- acetylmuramate:L- system permease/ E4664_RS09425 methyltransferase: regulator/proline (modulator of enol- pyrimidin- a,c-diamide bifunctional 3- E4664_RS14630 aconitate hydratase pyruvate glutamyl-L-lysyl- methyltransferase: E4664_RS02475 (guanine(2069)-N(7) a [cysteine desulfurase]- 7,8- gln acetyl phosphate NAD(P)- E4664_RS17995 glyoxylate muramoylpentapeptide beta-N- alanyl-gamma-D- ATPase: E4664_RS09430 E4664_RS02855 dehydrogenase/L- drug activity B): lactonase: 4(3H)-one adenosyltransferase: demethylubiquinone 3- α α Asp-tRNA(Asn) fumarate AcnA: acnA acetyl phosphate D-alanyl-D-alanine E4664_RS13465 )-methyltransferase S-sulfanyl-[disordered- D-ribulose dihydroneopterin Co -[ -(5-methylbenzimidazolyl) dependent alcohol putrescine ditrans,octacisacetylglucosaminyltransferase:- glutamyl- meso- E4664_RS10200 bifunctional glutamate gamma- E4664_RS09995 pcaD bifunctional E4664_RS00260 O-methyltransferase/2- β /Glu-tRNA(Gln) 3-oxoacid CoA- RlmK/23S rRNA 16S rRNA form scaffold 5-phosphate ]-Co -adenosylcobamide glutaminase: fumarate reductase/ bifunctional acetate kinase: dehydrogenase: succinate undecaprenyldiphospho-murG methylated-DNA-- diaminopimelate PilT/PilU family type metallophosphatase/ semialdehyde 3-oxoadipate diaminohydroxyphosphoribosylaminopyrimidine dihydroneopterin octaprenyl-6-hydroxy amidotransferase: aconitate hydratase E4664_RS17120 acetate kinase: N-acetyl-(N-acetyl-β-D- [protein]-cysteine S- transferase 5'-nucleotidase: (guanine(2445)-N(2) (uracil(1498)-N(3))- NADPH:quinone protein] complex adenosylcobinamide glutamine-- E4664_RS12190 succinate E4664_RS14330 urea degradation II UDP UDP-N-acetylmuramoyl-ligase: mpl 4a pilus ATPase: dehydrogenase: enol- 3,4- deaminase/5-amino-6-(5-phosphoribosylamino) aldolase: folB phenol methylase: gatB gatA gatC E4664_RS14330 γ subunit A: )-methyltransferase methyltransferase: reductase: cysteine tRNA ligase/ [+ 5 isozymes] dehydrogenase 2/2-methylisocitrate glucosaminyl)muramoyl- methyltransferase: L-alanyl- -D- E4664_RS12555 E4664_RS07150 putA lactonase: dihydroxy-2- uracil reductase RibD: ribD chorismate a 5-phosphooxy- ethanol 4-aminobutanal E4664_RS06375 7 RlmL: rlmKL 3 E4664_RS17835 E4664_RS14065 desulfurase: 6-(hydroxymethyl) bifunctional E4664_RS16595 superpathway of thiamine diphosphate biosynthesis II dehydratase: acetate L-alanyl-γ-D-glutamyl-L- E4664_RS15200 glutamyl-meso-2,6- a ribonucleoside an N - an N - pcaD butanone-4- 5-amino-6-(5- YqeY domain flavoprotein subunit: acetate urea H + phosphate ADP -7,8-dihydropterin 2-methoxy- gln ammonium L-glutamyl- E4664_RS05085 lysyl-D-alanyl-D-alanine a [protein]-S- acetoacetyl-CoA succinate 2069 1498 a semiquinone 4-methyl-3- F0F1 ATP E4664_RS09185 adenosylcobinamide fusion protein: a guanine in DNA diaminopimeloyl- methylguanine methyluracil glu + + an S-sulfanyl-[cysteine phosphate phospho-D- aminodeoxychorismate/ 6-(all-trans- [tRNA Gln ] E4664_RS07360 urease: ureC gamma- methyl-L-cysteine oxoadipate H H 2-amino-4-hydroxy-6- kinase/ E4664_RS05195 D-alanine in 23S rRNA in 16S rRNA synthase desulfurase]-S- synthase: ribosylamino)uracil anthranilate synthase octaprenyl)phenol cys a ThiS sulfur- an L-glutaminyl- cis-aconitate E4664_RS11915 aminobutyraldehyde hydroxymethyldihydropteridine adenosylcobinamide- succinate sulfanyl-[disordered- ribB bifunctional component II: carrier protein [tRNA Gln ] L-asparaginase/ ureA dehydrogenase: diphosphokinase: folK E4664_RS02765 phosphate a tRNA Gln aconitate hydratase ammonium E4664_RS11220 an O 4 - L-alanyl-γ-D- 3-(all-trans a [pyruvate form scaffold bifunctional diaminohydroxyphosphoribosylaminopyrimidine cysteine Glu-tRNAGln Macromolecule Modification 2-amino-6-[1-hydroxyethyl]- a [protein]- UDP-N-acetyl- guanylyltransferase: AcnA: acnA methylthymine methyl red adenosylcobinamide -decaprenyl) citrate a uridine in tRNA protein] complex deaminase/5-amino-6-(5-phosphoribosylamino) 2-amino-4-hydroxy-6- 4-amino-4- desulfurase: amidotransferase 7-methyl-7,8-dihydropterin α glutamyl-meso- dehydrogenase dGDP 3,4-dihydroxy- cobU 2-methoxy-6-all 4-aminobutanoate L-cysteine -D-muramate dITP 6 uracil reductase RibD: ribD hydroxymethyldihydropteridine deoxychorismate E4664_RS09185 subunit D: bifunctional 2-amino-4-hydroxy-6- in DNA methylated-DNA-- diaminopimelateUDP-N- FMN-dependent bifunctional benzene-1,2-diolbifunctional 3- bifunctional tRNA- E2 protein] N 2-butanone- 5-amino-6-(5- adenosyl- trans-octaprenyl- protein S-nitrosylation RdgB/HAM1 family non- ribonucleoside- pyrophosphokinase: an [L-cysteine a carboxy- E4664_RS14630 pyruvate fermentation aconitate hydratase hydroxymethyldihydropteridine [protein]-cysteine S- acetylmuramate:L- NADH- adenosylcobinamide demethylubiquinone 3- aconitate hydratase dihydrouridine -dihydrolipoyl- 4-phosphate phospho-D- aminodeoxychorismate cobinamide 1,4-benzoquinol and denitrosylation canonical purine NTP dihydrolipoyl diphosphate E4664_RS04560 desulfurase]-S- adenylated-[ThiS to (S)-acetoin 2/2-methylisocitrate diphosphokinase: folK methyltransferase: alanyl-gamma-D- azoreductase: kinase/ O-methyltransferase/2- 2/2-methylisocitrate synthase C: L-lysine a [cysteine synthase/GTP ribitylamino)uracil lyase: pabC phosphate bifunctional glu Asp-tRNA(Asn) pyrophosphatase: rdgB dehydrogenase: reductase: (7,8-dihydropterin- sulfanyl-L-cysteine sulfur-carrier protein] D-glyceraldehyde dehydratase: a [protein]- 2-amino-4-hydroxy-6- E4664_RS13465 glutamyl- meso- E4664_RS09555 adenosylcobinamide- octaprenyl-6-hydroxy dehydratase: E4664_RS13055 desulfurase]-(S- cyclohydrolase II: 6-yl)methyl bifunctional demethylmenaquinone /Glu-tRNA(Gln) phosphate nucleoside triphosphate lpdA E4664_RS13295 thioredoxin 4-aminobenzoate 3-phosphate pyruvate E4664_RS05085 L-cysteine Detoxification hydroxymethyldihydropteridine diaminopimelate FMN-dependent phenol methylase: E4664_RS05085 tRNA a [pyruvate sulfanyl) -[disordered- E4664_RS17405 diphosphate 5,6-dimethylbenzimidazole adenosylcobinamide methyltransferase/2- cysteine gly an L-glutamyl- amidotransferase: methylated-DNA-- guanylyltransferase: pyrophosphohydrolase: [+ 2 isozymes] E4664_RS13305 2 pathway 1-deoxy-D-xylulose- Glu acetolactate pyrophosphokinase: ligase: mpl NADH- E4664_RS16595 aconitate hydratase dihydrouridine dehydrogenase form scaffold 1-deoxy-L- kinase/ methoxy-6-polyprenyl- desulfurase: [tRNA ] gatB gatA gatC D-threo-isocitrate [protein]-cysteine S- UDP-N-acetyl- cobU 6-(all-trans- mazG GDP glu synthase: ilvN E4664_RS04560 synthase 6 glycero-tetrulose nicotinate-nucleotide-- 1,4-benzoquinol E4664_RS09185 5-phosphate a tRNA reactive oxygen species degradation [1-(2-amino-7-methyl-4-oxo- methyltransferase: α-D-muramoyl- azoreductase: decaprenyl)-2- AcnA: acnA E2 protein] N protein] complex ARP an oxidized adenosylcobinamide- E4664_RS14140 superoxide adenosyl-cobinamide dIMP DusB: dusB 4-phosphate dimethylbenzimidazole methylase UbiE: ubiE synthase: an L-glutaminyl- NADP-dependent a [protein] 3- Fatty Acid and Lipid Degradation arsenate 7,8-dihydro-3H-pteridin- E4664_RS15200 L-alanyl-γ-D- E4664_RS07375 methoxy-phenol D-threo-isocitrate a 5,6- -lipoyl-L-lysine thioredoxin phosphate (S)-2-acetolactate radicals N,N-dimethyl-1,4- phosphate phosphoribosyltransferase: 6-methoxy-3- E4664_RS18890 Gln detoxification 6-yl)]ethyl diphosphate a [protein]-S- anthranilate 7,8- guanylyltransferase: a thiocarboxy- [tRNA ] isocitrate nitrosothio- superoxide degradation a thymine in DNA glutamyl-meso-2,6- phenylenediamine dihydrouridine 6,7-dimethyl-8- cobT methyl-2-all- 1-deoxy-D-xylulose β II (glutaredoxin) methyl-L-cysteine dihydropteroate cobU [ThiS-Protein] 2-iminoacetate dehydrogenase: L-alanine oleate -oxidation diaminopimelate in tRNA a [cysteine desulfurase]- ribityllumazine trans-octaprenyl- 5-phosphate E4664_RS02245 androstenedione degradation superoxide arsenate thioredoxin- α-ribazole adenosylcobinamide- isoleucine- superoxide dismutase: [scaffold protein- synthase: ribE bifunctional 1,4-benzoquinol AIR ile superoxide arsenate disulfide 5'-phosphate GDP -tRNA NADP-dependent oleate E4664_RS02825 sn-glycero-3- 6-methoxy-2-all- (2Fe-2S)] complex tetrahydrofolate thiazole synthase: dismutase: reductase: a DNA methyl a [protein]- carbamoyl NaMN reductase: ligase: ileS an L-isoleucyl- diacetyl isocitrate androst-4-ene-3,17-dione Reactive Blue 5 phospho-N- asp trans-octaprenyl- DHAP 6,7-dimethyl-8-(1- synthase/ phosphomethylpyrimidine E4664_RS03775 hydrogen peroxide E4664_RS02825 phosphotriester L-cysteine phosphate GTP H O XTP IMP dADP [tRNA Ile ] dehydrogenase: a [protein]- long-chain fatty hydrogen E4664_RS17675 1,4-benzoquinone 5'-nucleotidase SurE: 2 D-ribityl)lumazine trxB dihydrofolate adenosylcobinamide- synthase ThiC: thiC S-nitrosoglutathione Dyp-type (arachidonoyl) methylated-DNA-- aspartate bifunctional NAD(P)H- benzimidazolyl adenosylcobamide a tRNA Ile acetoin reductase: E4664_RS02235 L-cysteine acid--CoA ligase: peroxide arsenite ribosome RdgB/HAM1 family non- bifunctional ribonucleoside- synthase: folC GDP 3-demethylubiquinol-8 2-[(2R,5Z)-2-carboxy- peroxidase: ethanolamineglycerophosphodiester [protein]-cysteine S- carbamoyltransferase: demethylmenaquinone E4664_RS02475 dependent a [co-chaperone]- riboflavin synthase: 4-methylthiazol-5(2H)- biosynthesis from E4664_RS07430 E4664_RS06740 catalase/peroxidase catalase/ E4664_RS16075 phosphodiesterase: methyltransferase: small subunit- canonical purine NTP metallophosphatase/ glycerol-3- diphosphate 7,8-dihydrofolate ribazoletransferase: HMP-P 2-oxoglutarate S-(hydroxymethyl) E4664_RS10530 methyltransferase/2- bifunctional [scaffold protein- E4664_RS15635 ylidene]ethyl phosphate adenosylcobinamide-GDP [+ 3 isozymes] HPI: katG peroxidase E4664_RS01415 E4664_RS13465 dependent pyrophosphatase: rdgB 5'-nucleotidase: phosphate reductase: a reduced monoglutamate E4664_RS07680 (S)-acetoin glutathione androsta-1,4-diene-3,17-dione Dyp-type aspartate methoxy-6-polyprenyl- metallophosphatase/ (2Fe-2S)] complex hydroxymethylpyrimidine/ HPI: katG GTPase A: rsgA nucleoside triphosphate E4664_RS07150 dehydrogenase: E4664_RS13295 riboflavin thioredoxin benzimidazole dehydrogenase/ oleoyl-CoA catalase: peroxidase: glycerophosphodiester methylated-DNA-- carbamoyltransferase 1,4-benzoquinol 5'-nucleotidase: pyrroloquinoline phosphomethylpyrimidine H O hydroxyl radical catalase: [+ 3 isozymes] pyrophosphohydrolase: 5'-nucleotidase SurE: E4664_RS03820 E4664_RS13305 adenosylcobalamin nicotinate-nucleotide-- leucine-- class III alcohol E4664_RS07080 2 arsenite E4664_RS07890 phosphodiesterase: [protein]-cysteine S- catalytic subunit: 3-methyl-6-methoxy-methylase UbiE: ubiE E4664_RS07150 quinone biosynthesis leu 3-[(4-amino-6-chloro- + bifunctional ubiquinol-8 kinase: E4664_RS12905 dimethylbenzimidazole tRNA ligase: dehydrogenase: acyl-CoA E4664_RS07080 2,2'-disulfonyl E4664_RS00255 methyltransferase: β phosphate GDP H mazG E4664_RS02475 sn-glycerol ADP 5'-phosphate 2-(2-carboxy-4- 1,3,5-triazin-2-yl) phthalate sn-glycerol E4664_RS10535 2-octaprenyl-1,4- -D-ribosylnicotinate a [chaperone-ATP]- riboflavin phosphoribosyltransferase: E4664_RS14150 E4664_RS14050 dehydrogenase: azobenzene anandamide E4664_RS15200 N-carbamoyl- XMP inosine 3-phosphate a 7,8-dihydrofolate HMP-PP methylthiazol-5- an L-leucyl- α O O amino]benzenesulfonate 3-phosphate benzoquinone [co-chaperone]- Pentose Phosphate Pathways 9 -hydroxyandrosta- 2 2 a [protein]-S- kinase/FAD a PqqA peptide SAM yl)ethyl phosphate cobT [tRNA Leu ] S-(hydroxymethyl) E4664_RS07800 [DNA] L-aspartate [scaffold protein- benzimidazole Leu 1,4-diene-3,17-dione methyl-L-cysteine synthetase: dihydrofolate a tRNA glutathione [+ 17 isozymes] (2Fe-2S)] complex ribotide phosphate ribF reductase: a PqqA peptide with thiamine pentose phosphate pathway (non-oxidative branch) dehydrogenase/ (2E,9Z)- adenosylcobalamin adenosylcobinamide- E4664_RS14465 linked Glu-Tyr residues phosphate class III alcohol octadecenoyl-CoA a mature peptidoglycan a (2R)-2-hydroxy all trans-decaprenyl- 3-(all-trans- FMN GDP superpathway of thiamine diphosphate biosynthesis I tetrapyrrole biosynthesis synthase: D-ribulose dehydrogenase: enol-CoA 3-hydroxy-9,10- (meso-diaminopimelate even numbered glycerophosphoserine 2-methoxy-6- nonaprenyl) DMKH2-11 a cytosine in DNA pyrazinamide roseoflavin a tetrahydrofolate E4664_RS02310 ribazoletransferase: 5-phosphate secoandrosta-1,3,5(10) ITP GTP ATP bifunctional I (from glutamate) valine-- E4664_RS07070 hydratase: containing) straight chain glycerophosphodiester 1,4-benzoquinol benzene-1,2-diol bifunctional DNA cytosine bifunctional 5'-phosphate a [chaperone- E4664_RS07680 val -triene-9,17-dione lytic murein bifunctional bifunctional 3- RdgB/HAM1 family non- an [2Fe-2S] riboflavin α α tRNA ligase: E4664_RS01890 2,3,4-saturated phosphodiesterase: demethylmenaquinone methyltransferase: bifunctional nicotinamidase/ bifunctional ADP]-[disordered- cys 2-amino-4-[5-(2-amino- Co -[ -(benzimidazolyl) ribose-5- ribulose-phosphate S-(hydroxysulfenamide) transglycosylase: long-chain fatty demethylmenaquinone demethylubiquinone 3- canonical purine NTP cluster protein kinase/FAD pyridoxal 5'-phosphate biosynthesis I glu β E4664_RS00990 fatty acid E4664_RS00255 methyltransferase/2- E4664_RS10875 diguanylate cyclase/ pyrazinamidase: riboflavin form scaffold 2-carboxylatoethyl)-2- thiamine phosphate ]-Co -adenosylcobamide an L-valyl- phosphate 3-epimerase: glutathione (S)-3-hydroxy-(9Z) E4664_RS16775 acid--CoA ligase: methyltransferase/2- O-methyltransferase/2- pyrophosphatase: rdgB synthetase: Val glycerophosphodiester methoxy-6-polyprenyl- DNA cytosine phosphodiesterase: pncA kinase/FAD protein] complex cysteine hydroxyphenyl]pentanedioate 5'-phosphate [tRNA ] isomerase E4664_RS13500 -octadecenoyl-CoA a mature peptidoglycan [+ 3 isozymes] E4664_RS06740a (R)-2-hydroxy methoxy-6-polyprenyl- octaprenyl-6-hydroxy ribF D-erythrose thiamine- a tRNA Val 3,4-dihydroxy-9,10- Alcohol Degradation phosphodiesterase: 1,4-benzoquinol methyltransferase: nucleoside triphosphate E4664_RS14125 amidase: synthetase: desulfurase: RpiA: rpiA with (L-alanyl-γ-D- a mature peptidoglycan [+ 3even isozymes] numbered 1,4-benzoquinol phenol methylase: 4-phosphate an L-glutamyl- phosphate secoandrosta-1,3,5(10) E4664_RS01415 methylase UbiE: ubiE E4664_RS04735 pyrophosphohydrolase: E4664_RS06510 ribF E4664_RS09185 D-xylulose glutamyl-meso-2,6- strand (non- diphosphate AMP straight chain 6-methoxy-3-methyl-methylase UbiE: ubiE 2-methoxy- E4664_RS16595 diguanylate cyclase: roseoflavin adenine FAD [tRNA Glu ] -triene-9,17-dione a 5-methylcytosine mazG pyrazine-2- an [L-cysteine kinase: thiL 5-phosphate hydroxylamine glycerol and glycerophosphodiester degradation 2,3,4-saturated sn-glycerol 2-all-trans-decaprenyl- 6-(all-trans- menaquinol-11 E4664_RS02100 dinucleotide an [Fe-S cluster a ThiS sulfur- 2-amino-4-[3-(2-amino-2- Coα-[α-(benzimidazolyl) D-ribose 5- 3-oxo-(9Z)- diaminopimeloyl-D- reducing terminus) ser in DNA IMP c-di-GMP carboxylate desulfurase]-S- glutamyl-tRNA fatty acyl CoA 3-phosphate 1,4-benzoquinol nonaprenyl)phenol biosynthesis carrier protein carboxylatoethyl)-6-oxocyclohexa- thiamine diphosphate ]-Coβ-adenosylcobamide phosphate octadecenoyl-CoA alanine) tetrapeptide sulfanyl-L-cysteine 4-phospho- reductase: alanine- chaperone]-ATP cysteine 1,4-dien-1-yl]pentanedioate acetyl-CoA C- a glycerophosphodiester D-erythronate E4664_RS12825 -tRNA (1E,2Z)-3-hydroxy- desulfurase: ala transketolase: tkt acyltransferase 10 ligase: 5,9,17-trioxo-4,5:9,10- 4-phosphoerythronate (S)-4-amino-5- N -formyl-tetrahydrofolate biosynthesis 2-methoxy-6-all a 3-(all-trans 2030 E4664_RS09185 alaS an L-alanyl- ammonium FadA: fadA disecoandrosta-1 glycerophosphodiester 3-aci- aci-nitroethane glycerophosphoglycerol DMKH2-10 adenine cyclic-AMP (2R,3S)-2- sn-glycerol a [ThiI sulfur- a carboxy- dehydrogenase: oxopentanoate D-sedoheptulose D-glyceraldehyde trans-heptaprenyl- -polyprenyl) L-ornithine D-glyceraldehyde 6-(2-amino-2-carboxylatoethyl) base-degraded Ala (10),2-dien-4-oate phosphodiesterase: glycerol nitropropanoate in 23S rRNA methylisocitrate 3-phosphate E4664_RS01600 glutamate-1- [tRNA ] 7-phosphate 3-phosphate (7Z)-hexadecenoyl-CoA nitronate nitronate glycerophosphodiester 1,4-benzoquinol benzene-1,2-diol bifunctional 23S rRNA 3',5'-cyclic-AMP bifunctional glycerol-3- adenosylcobalamin carrier protein]-S- adenylated-[ThiS -1,2,3,4-tetrahydroquinoline- a tetrahydrofolate thiamine salvage Ala E4664_RS00255 bifunctional bifunctional 3- arginine N- 3-phosphate a tRNA monooxygenase: monooxygenase: phosphodiesterase: (adenine(2030)-N(6) phosphodiesterase: salvage from cobalamin tyr sulfanyl-L-cysteine sulfur-carrier protein] 2,4-dicarboxylate (3R)-3-hydroxy-2-oxo- semialdehyde- demethylmenaquinone demethylubiquinone 3- demethylmenaquinone succinyltransferase: aconitate phosphate 1-O- 1-deoxy-D-xylulose- formylaminopyrimidine acyl-CoA glycerophosphodiester glycerol E4664_RS09475 E4664_RS09475 E4664_RS01415 )-methyltransferase cpdA 4 phosphooxybutanoate 2,1- transaldolase: tal methyltransferase/2- O-methyltransferase/2- methyltransferase/2- astA hydratase 2/2- acyltransferase AIR 5-phosphate tRNA processing dehydrogenase: phosphodiesterase: kinase RlmJ: cob(I)alamin 3-phosphoserine/ aminomutase: methionine 3-[(3aS,4S,7aS)-7a-methyl- nitronate nitronate glycerophosphodiester methoxy-6-polyprenyl- octaprenyl-6-hydroxy methoxy-6-polyprenyl- 3',5'-cyclic-nucleotide methylisocitrate 1-(18- PlsB: plsB synthase: hemL E4664_RS07800 (2Z,4Z)-2-hydroxyhexa- E4664_RS01415 GlpK: glpK 1,4-benzoquinol E4664_RS19345 phosphodiesterase: arginine N- dehydratase: phosphohydroxythreonine synthase: metH aminomethylpyrimidine D-erythrose 1,5-dioxo-octahydro-1H monooxygenase: monooxygenase: phosphodiesterase: 1,4-benzoquinol phenol methylase: an N 6 - hydroxyoleoyl) phosphomethylpyrimidine E4664_RS18890 6-(2-amino-2-carboxylatoethyl) F6P [+ 17 isozymes] 2,4-dienoate methylase UbiE: ubiE E4664_RS01390 succinyltransferase: E4664_RS05085 transaminase: serC asn 4-phosphate a polycistronic -inden-4-yl]propanoate E4664_RS02165 E4664_RS02165 E4664_RS00255 6-methoxy-3-methyl-2-methylase UbiE: ubiE a 2-methoxy-E4664_RS16595 methyladenine 2030 -sn-glycrol synthase ThiC: thiC a thiocarboxy- -7-hydroxy-8-oxo-1,2,3,4,7,8- 5-aminolevulinate methionine synthase: sn-glycerol [unspecified [unspecified astA cis-2- 1-deoxy-D-xylulose thiaminase tRNA precursor (2E,7Z)- sn-glycerol menaquinol-10 N 2 -succinyl- cob(II)alamin 2-iminoacetate [ThiS-Protein] hexahydroquinoline- D-glyceraldehyde 4-phosphooxy- E4664_RS13330 acyl-CoA degradation nitrite 3-oxopropanoate degradation nitrite acetaldehyde glycerol all-trans-heptaprenyl- 6-(all-trans- in 23S rRNA 3-phosphate 5-phosphate pyruvate II: tenA an L-asparaginyl- transketolase: tkt hexadecenoyl-CoA 3-phosphate 3-phosphate AMP L-ornithine methylaconitate HMP-P 2,4-dicarboxylate 3-phosphate L-threonine porphobilinogen synthetase: products] products] 1,4-benzoquinol polyprenyl)phenol cob(I)yrinic acid [tRNA Asn ] enol-CoA 4-hydroxythreonine- 4-amino-2-methyl-5- (S)-4-hydroxy- E4664_RS13800 a,c-diamide thiazole synthase: synthase: hemB tRNA Asn D-glyceraldehyde hydratase: 3-[(3aS,4S,7aS)-7a-methyl- hydroxymethylpyrimidine/ 1-deoxy-D-xylulose- 4-phosphate dihydrofolate reductase: pyrimidinemethanol 2-oxohexanoate adenosyltransferase: E4664_RS03775 3-phosphate E4664_RS01890 1,5-dioxo-octahydro-1H- phosphomethylpyrimidine 5-phosphate porphobilinogen E4664_RS14465 a tRNA precursor a tRNA precursor with dehydrogenase phosphoenol an [HPr]- an sn-glycero-3- 1-myristoyl- 2-methoxy-6-all α-D-mannose guanosine 2251 a diphthine- an oxidized E4664_RS00260 kinase: E4664_RS12905 6-(2-amino-2-carboxyethyl) synthase: serine (S)-3-hydroxy-(7Z) inden-4-yl]propanoyl-CoA DHAP DMKH2-13 coniferaldehyde D-glucopyranose 2-[(2R,5Z)-2-carboxy- PdxA: pdxA glycine cleavage system with a 5' extension a 5' extension and pyruvate L-histidine phospho-N-(acyl) a palmitoleoyl-[acp] sn-glycerol trans-nonaprenyl- 1-phosphate in 23S rRNA [translation nitroaromatic cob(II)alamin- -7,8-dioxo-1,2,3,4,7,8- E4664_RS18890 hydroxymethylbilane a 7,8-dihydrofolate hydroxymethyltransferase: a 5-methyltetrahydrofolate -hexadecenoyl-CoA HMP-PP 4-methylthiazol-5(2H)- 3-amino-1- protein GcvH: gcvH and a long 3' trailer a short 3' extension phosphoenolpyruvate- ethanolamineglycerophosphodiester 3-phosphate 1,4-benzoquinol phosphomannomutase/ bifunctional 23S rRNA coniferyl aldehyde glucose 1- elongation compoundoxygen- [corrinoid hexahydroquinoline 1-deoxy-D-xylulose synthase: hemC E4664_RS03550 aspartate- ribonuclease 1-acyl-sn-glycerol- bifunctional ylidene]ethyl phosphate hydroxyacetone ribonuclease D: -protein phosphodiesterase: phosphoglucomutase: demethylmenaquinone (guanosine(2251) dehydrogenase: dehydrogenase: factor 2] insensitive adenosyltranferase] 2,4-dicarboxylate 5-phosphate -tRNA ribonuclease PH: P protein 1-propanal pyruvate 5-hydroxy-3-[(3aS,4S Carboxylate Degradation 3-phosphate demethylmenaquinone diphthine-- 1-phosphate asp E4664_RS07525 phosphotransferase: ptsP E4664_RS00255 E4664_RS12605 methyltransferase/2- -2'-O)- E4664_RS11185 E4664_RS09285 NAD(P)H pyrroloquinoline- preuroporphyrinogen ligase: ribonuclease D: E4664_RS16565 component: ,5R,7aS)-7a-methyl-1,5- acyltransferase: methyltransferase/2- ammonia ligase: thiamine thymidylate phosphoenolpyruvate- phosphomannomutase/ methoxy-6-polyprenyl- methyltransferase coniferyl aldehyde glucose 1- nitroreductase: quinone synthase pyridoxine 5'- aspS an L-aspartyl- E4664_RS07525 rnpA 3-oxo-(7Z)- dioxo-octahydro-1H- pyruvate fermentation glycerophosphodiester E4664_RS194701-myristoyl-2- methoxy-6-polyprenyl- E4664_RS01910 phosphate uroporphyrinogen- synthase: thyA -protein phosphoglucomutase: 1,4-benzoquinol RlmB: rlmB dehydrogenase: dehydrogenase: a diphthamide- nfsB PqqC: pqqC [tRNA asp ] hexadecenoyl-CoA superpathway of acetate D-gluconate phosphodiesterase: palmitoleoyl- 1,4-benzoquinol 2-O- a reduced cob(I)alamin- synthase: molybdenum cofactor biosynthesis phosphate a tRNA precursor with inden-4-yl]propanoyl-CoA to acetate IV acyl-carrier protein methylase UbiE: ubiE E4664_RS06715 [translation III synthase: asp acetyl-CoA C- utilization and formation degradation phosphotransferase: ptsP E4664_RS01415 methylase UbiE: ubiE E4664_RS16395 methylguanosine 2251 E4664_RS14505 nitroaromatic [corrinoid E4664_RS02310 synthase: pdxJ tRNA an [HPr protein]- sn-glycerol 6-methoxy-3-methyl-2- D-mannopyranose D-glucono- elongation pyrroloquinoline quinone E4664_RS15450 a short 3' extension propanoyl-CoA π sn-glycerol an N- adenosyltranferase] a (6S)-5-formyltetrahydrofolate a tRNA precursor acyltransferase pyruvate N -phospho- pyruvate 3-phosphate all-trans-nonaprenyl- menaquinol-13 in 23S rRNA ferulate compound bifunctional D-gluconate 3-phosphate acylethanolamine 6-phosphate 1,5-lactone factor 2] cob(I)yrinic acid with a 5' extension FadA: fadA acetate L-histidine 1,4-benzoquinol cys ATP uroporphyrinogen-III methylenetetrahydrofolate 5-formyltetrahydrofolate (2E)-3-[(3aS,4S,5R,7aS) acetate--CoA a,c-diamide thiamine phosphate GTP pyridoxine 5'-phosphate methylenetetrahydrofolate ribonuclease PH: ribonuclease D: gluconokinase: dehydrogenase/ cyclo-ligase: (5Z)-tetradecenoyl-CoA -5-hydroxy-7a-methyl-1- ligase: acs adenosyltransferase: reductase [NAD(P)H]: metF E4664_RS16565 E4664_RS07525 acetate kinase: E4664_RS14310 cysteine pyridoxamine methenyltetrahydrofolate E4664_RS11815 tyrosine-- oxo-octahydro-1H-inden- D-gluconate a ring-opened 7- sn-glycero-3- 1-palmitoyl- a 2-methoxy-6-all- 3-benzyl-3,6- a 1-acyl-sn E4664_RS00260 thiamine- tyr E4664_RS14330 DMK-12 a RNA-DNA hybrid acetyl-CoA D-glucopyranose desulfurase: GTP 3',8- 5'-phosphate cyclohydrolase FolD: folD tRNA ligase: acyl-CoA 4-yl]prop-2-enoyl-CoA 6-phosphate methylguanine in DNA phosphoethanolamine a palmitoleoyl-[acp] sn-glycerol trans-polyprenyl- dihydroxy-6- -glycerol 3- adenosylcob(III) phosphate a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate glutathione dIDP E4664_RS09185 cyclase E4664_RS16955 an L-tyrosyl- dehydrogenase: acetyl-CoA formate bifunctional DNA- glycerophosphodiester 3-phosphate 1,4-benzoquinol (hydroxymethyl) bifunctional ribonuclease acetyl-CoA glucose 1- phosphate alamin-[corrinoid kinase: thiL oxidase: pdxH folate transformations I glyoxylate cycle acetyl phosphate acetyl-CoA 1-acyl-sn-glycerol- bifunctional glutathione S- 1-acyl-sn-glycerol- an [L-cysteine a carboxy-adenylated MoaA: moaA Tyr E4664_RS09405 formamidopyrimidine phosphodiesterase: -diketopiperazine HII: rnhB carboxylase dehydrogenase: nucleoside- adenosyltranferase] bifunctional [tRNA ] queuosine biosynthesis 3-phosphate demethylmenaquinone demethylmenaquinone 3-phosphate desulfurase]-S- [small subunit of (8S)-3',8-cyclo-7,8- di-trans,poly-cis-undecaprenyl Tyr phosphate transferase: E4664_RS06715 diphosphate thiamine diphosphate PLP methylenetetrahydrofolate a tRNA [+ 17 isozymes] glycosylase/ E4664_RS00255 acyltransferase: methyltransferase/2- methyltransferase/2- DNA polymerase carboxyltransferase acyltransferase: cob(I)yrinic acid sulfanyl-L-cysteine molybdopterin synthase] dihydroguanosine phosphate biosynthesis succinate an uncharged tRNA 3-[(3aS,4S,5R,7aS)-5- acetyltransferase: E4664_RS08750 kinase: a tetrahydrofolate dehydrogenase/ acetyl-CoA glyoxylate (2E,5Z)- DNA-(apurinic glycerophosphodiester E4664_RS19470 methoxy-6-polyprenyl- methoxy-6-polyprenyl- III subunit subunit alpha: glucose 1- E4664_RS19470 a,c-diamide 5'-triphosphate preQ hydroxy-7a-methyl-1-oxo- E4664_RS14335 phosphate L-malate 1-palmitoyl-2- 3-benzyl-3,6[+ - 6 isozymes] a 1-acyl-2- E4664_RS14260 (2E,6E)-farnesyl methenyltetrahydrofolate 0 tetradecenoyl-CoA or apyrimidinic phosphodiesterase: 1,4-benzoquinol 1,4-benzoquinol epsilon: dnaQ E4664_RS13700 dehydrogenase: adenosyltransferase: IPP NADPH-dependent 7- octahydro-1H-inden-4-yl]- acetyltransferase: degradation II palmitoleoyl- bis(glutathione)- arachidonoyl- diphosphate cyclohydrolase FolD: folD malate synthase G: site) lyase: mutM E4664_RS01415 acyl-carrier protein methylase UbiE: ubiE methylase UbiE: ubiE a nucleoside 5'- [+ 3 isozymes] E4664_RS09285 dITP E4664_RS00260 di-trans,poly-cis- isocitrate lyase: cyano-7-deazaguanine 3-hydroxypropanoyl-CoA acetyl phosphate E4664_RS14335 2,6-diamino-4- sn-glycerol a 6-methoxy-3-methyl- 6-(hydroxymethyl) DNA sn-glycerol tryptophan- E4664_RS08000 enol-CoA an apurinic site sn-glycerol menaquinol-12 monophosphate malonyl-CoA D-glucono- decaprenylcistransferase: formyltetrahydrofolate Trp reductase QueF: queF (S)-malate hydroxy-5-(N-methyl) ethanolamine 3-phosphate 2-all-trans-polyprenyl- -diketopiperazine 3-phosphate adenosylcobalamin NAD salvage pathway I (PNC VI cycle) a thiocarboxylated a 10-formyltetrahydrofolate a tRNA E4664_RS11940 hydratase: within DNA 3-phosphate 1,5-lactone cyclic pyranopterin di-trans,octa-cisuppS deformylase: purU -tRNA preQ acetate kinase: NAD-dependent formamidopyrimidine 1,4-benzoquinol [small subunit of 1 E4664_RS01890 molybdopterin synthase] phosphate -undecaprenyl ligase: trpS an L-tryptophanyl- (3E,5Z)-tetradeca- E4664_RS14330 malic enzyme: + 3-[(3aS,4S,5R,7aS)-5- NAD diphosphate [tRNA Trp ] tRNA guanosine(34) 3,5-dienoyl-CoA E4664_RS16085 (S)-3-hydroxy-(5Z) hydroxy-7a-methyl-1-oxo- a 7,8-dihydro-8- 1-stearoyl- 2-all trans-hexaprenyl- adenine 1518 / 2-bromo-3-(4- a [release factor]- 1-myristoyl- 1-palmitoyl- undecaprenyl- trp transglycosylase Tgt: tgt acetate pyruvate poly-β-1,6-N-acetyl-D-glucosamine DMKH -tetradecenoyl-CoA octahydro-1H-inden-4- oxoguanine in DNA a palmitoyl-[acp] sn-glycerol 6-methoxyhydroquinone adenine 1519 in 16S rRNA glutathione nitrophenyl) L-glutamine 2 sn-glycerol sn-glycerol diphosphatase: a 10- a 7-aminomethyl-7- poly-beta-1,6-N-acetyl- IDP glycine yl]-3-oxopropanoyl-CoA bifunctional DNA- 1-acyl-sn-glycerol-3-phosphate bifunctional 16S rRNA propanoateglutathione S- peptide chain bifunctional 3-phosphate1-acyl-sn-glycerol- 3-phosphate1-acyl-sn-glycerol- E4664_RS16810 formyltetrahydrofolate D-threo-isocitrate (S)-malate deazaguanosine 34 in tRNA D-glucosamine N- nucleoside- methionine cleavage (3E,5Z)- formamidopyrimidine 3-phosphate demethylmenaquinone (adenine(1518)-N(6)/ transferase: release factor demethylmenaquinone 3-phosphate 3-phosphate NAD(+) molybdopterin deacetylase PgaB: pgaB diphosphate undecaprenyl- synthase: system a (6S)-5- aconitate hydratase tRNA preQ1(34) S- tetradecadienoate acetyl-CoA C- glycosylase/ acyltransferase: methyltransferase/2- adenine(1519)-N(6))- E4664_RS08750 N(5)-glutamine methyltransferase/2- acyltransferase: acyltransferase: diphosphatase: diphosphate metH bifunctional formyltetrahydrofolate threonine- 3-oxo-(5Z)- acyltransferase Degradation/Utilization/Assimilation - Other kinase: protein thr AcnA: acnA adenosylmethionine poly-beta-1,6-N-acetyl- DNA-(apurinic E4664_RS19470 methoxy-6-polyprenyl- dimethyltransferase [+ 6 isozymes] methyltransferase: methoxy-6-polyprenyl- 1-myristoyl-2-E4664_RS19470 1-palmitoyl-2-E4664_RS19470 nudC phosphatase: methylenetetrahydrofolate -tRNA ribosyltransferase- tetradecenoyl-CoA FadA: fadA D-glucosamine N- or apyrimidinic 1-stearoyl- 1,4-benzoquinol RsmA: rsmA 2-(glutathion- prmC 1,4-benzoquinol E4664_RS14260 methionine GcvH: bifunctional NAD-dependent N 6 -dimethyladenine 1518 palmitoleoyl- palmitoleoyl- E4664_RS00820 dehydrogenase/ 5-formyltetrahydrofolate ligase: thrS isomerase QueA: queA acetyl-CoA C- deacetylase PgaB: pgaB site) lyase: mutM acyl-carrier protein 2-palmitoyl- methylase UbiE: ubiE bromide S-yl)-3-(4- a [release factor]-N 5 methylase UbiE: ubiE synthase: gcvH an L-threonyl- aconitate hydratase malic enzyme: octane oxidation 2-all-trans-hexaprenyl- /N 6 -dimethyladenine 1519 sn-glycerol sn-glycerol ITP nicotinate adenine molybdopterin Thr 3-[(3aS,4S,5R,7aS)- acrylonitrile β sn-glycerol nitrophenyl) NMN di-trans,octa-cis- E4664_RS13330 methenyltetrahydrofolate cyclo-ligase: [tRNA ] acyltransferase partially deacetylated poly- - an apurinic site 7,8-dihydro- -methyl-L-glutamine 2/2-methylisocitrate E4664_RS16085 34 acetyl-CoA acetate 6-methoxy-3-methyl- in 16S rRNA MQH 3-phosphate 3-phosphate dinucleotide adenine dinucleotide cyclohydrolase FolD: folD E4664_RS11815 Thr an epoxyqueuosine in tRNA 5-hydroxy-7a-methyl- degradation I 1,6-N-acetyl-D-glucosamine within DNA 8-oxoguanine 3-phosphate propanoate 2 undecaprenyl phosphate a tRNA dehydratase: FadA: fadA molybdopterin bifunctional 1-oxo-octahydro-1H- NADH 1,4-benzoquinol E4664_RS05085 epoxyqueuosine (3Z)-dodec- nicotinate-nicotinamide molybdotransferase methylenetetrahydrofolate a 5,10- indene-4-carboxyl-CoA acrylonitrile reductase QueH: 3-enoyl-CoA nucleotide MoeA: thiamine salvage IV (yeast) serine dehydrogenase/ methenyltetrahydrofolate an odd numbered 4-hydroxy- UDP-N-acetyl- a (3R)-3- a 1-acyl-sn cis-aconitate acetyl-CoA oxaloacetate E4664_RS09775 N 6 -dimethylallyladenosine 37 a sulfurated 3-(all-trans-heptaprenyl) 5'-deoxy-5'- a [protein]-L- adenylyltransferase: E4664_RS05790 hydroxymethyltransferase: methenyltetrahydrofolate NAD de novo biosynthesis a reduced straight chain decanoate 3'-dephospho- glutathione α-D-glucosamine hydroxyhexacosanoyl- -glycerol 3- serine- octane in tRNA [sulfur carrier] benzene-1,2-diol ATP fluoroadenosine 2-nonenal methionine E4664_RS03550 I (from aspartate) aconitate hydratase 34 triacylglycerol rubredoxin acrylamide 2,3,4-saturated long-chain fatty CoA pyrimidine/purine glutathione S- UDP-N- phosphate peptide- E4664_RS01895 MoO -molybdopterin thiamine cyclohydrolase FolD: folD -tRNA a queuosine in tRNA (5R,7aS)-5-hydroxy- succinate bifunctional 3- [acp] 3-hydroxyacyl- 1-acyl-sn-glycerol- 2 ser AcnA: acnA degradation fatty acidlong-chain fatty acid--CoA ligase: triphosphoribosyl- nucleoside transferase: acetylglucosamine methionine cofactor ligase: (2E)-dodec- 7a-methyl-1-oxo- alkane 1- dehydrogenase, demethylubiquinone 3- ACP 3-phosphate bifunctional amidase: acid--CoA ligase: E4664_RS06740 dephospho- phosphorylase: E4664_RS08750 2-epimerase (non- (S)-S-oxide asp serS an L-seryl- 2-enoyl-CoA a triacyl-sn 3,5,6,7-tetrahydro-2H- monooxygenase: hydrophobic O-methyltransferase/2- dehydratase acyltransferase: NaMN nicotinamide aconitate hydratase E4664_RS06510 E4664_RS06740 CoA synthase: E4664_RS15150 hydrolyzing): reductase thiaminase II: tenA ser enol-CoA indene-4-carboxyl-CoA E4664_RS07805 [+ 3 isozymes] octaprenyl-6-hydroxy [+ 6 isozymes] E4664_RS19470 bifunctional a 5,10- L-aspartate [tRNA ] -glyceroltriacylglycerol membrane anchor an odd numbered E4664_RS09105 (glutathion-S- FabZ: fabZ a 1-acyl-2- nicotinate thiamine salvage II ser 2/2-methylisocitrate [+ 3 isozymes] phenol methylase: 2'-(5''-triphospho- 5-fluoro-5- E4664_RS16440 a trans-hexacos- MsrA: msrA nicotinamidase/ a 5-methyltetrahydrofolate oxidase: nadB a tRNA citrate (Si)- hydratase: protein: sdhD 2-methylsulfanyl-N 6 - straight chain yl)-4-hydroxy- palmitoyl-sn a protein-L- phosphoribosyltransferase: methylenetetrahydrofolate dehydratase: lipoprotein posttranslational modification lipase: 1-octanol acrylate diphosphate AMP diphosphate AMP decanoyl-CoA E4664_RS16595 adenine α-D-ribosyl)-3'- deoxy-D-ribose adenine [+ 2 isozymes] 2-enoyl-[acp] 4-amino-2-methyl-5- 2-iminosuccinate E4664_RS01890 an unsulfurated 37 2-nonenal α -glycerol 3- methionine- pncB pyrazinamidase: 5-(2-hydroxyethyl)-4-methylthiazole 4-amino-2-methyl-5- E4664_RS05085 synthase: gltA E4664_RS18620 met 5'-deoxyadenosine dimethylallyladenosine 2,3,4-saturated 2-methoxy-6-(all-trans dephospho-CoA 1-phosphate UDP-N-acetyl- - pncA pyrimidinemethanol methylenetetrahydrofolate (S)-3- a 1,2-diacyl- (5R,7aS)-7a-methyl-1,5- [sulfur carrier] in tRNA fatty acyl CoA phosphate (S)-S-oxide pyrimidinemethanol quinolinate a [prolipoprotein]- -heptaprenyl)phenol D-mannosamine adeninyl adenosylcobamide nicotinate hydroxymethylpyrimidine/ hydroxyethylthiazole reductase [NAD(P)H]: metF hydroxydodecanoyl-CoA sn-glycerol dioxo-3,5,6,7-tetrahydro- synthase citrate L-cysteine biosynthesis from phosphoribosyltransferase: phosphomethylpyrimidine kinase: thiM hydroxymethylpyrimidine/ 2H-indene-4-carboxyl-CoA NadA: nadA proline-- prolipoprotein E4664_RS06920 kinase: E4664_RS12905 phosphomethylpyrimidine pro a [2-oxoglutarate- a 2-methyl 34 a (3R)-3- (R)-4-hydroxy- adenosylcobinamide-GDP tRNA ligase: diacylglyceryl 1-octanal 1-aminocyclopropane- a guanine 1-(18-hydroxyoleoyl)- a ribonucleoside 4-methyl-5-(2- kinase: E4664_RS12905 dehydrogenase branched 2,3,4- linoleate demethylmenaquinol-4 queuine hydroxytetracosanoyl- 4-methyl-2- roseoflavin thiamine formation from HMP-P phosphooxyethyl)thiazole quinolinate E4664_RS00545 an L-prolyl- transferase: SAM a sulfurated [sulfur carrier] 1-carboxylate in tRNA sn-glycrol 3-phosphate diphosphate nicotinate 5-(2-hydroxyethyl) a 2-acylglycerol E2 protein] N 6 - saturated fatty acid long-chain fatty bifunctional tRNA 1-acyl-sn-glycerol- ribonucleoside- [acp] oxoglutarate bifunctional adenine HMP-P Pro E4664_RS14445 3-oxododecanoyl-CoA long-chain fatty 1-aminocyclopropane- 3-hydroxyacyl- putative 4- pyrithiamine and oxythiamine (yeast) thiamine phosphate [tRNA ] (3R)-2-(2-carboxyethyl)- lipoyl acid--CoA ligase: riboflavin hydroxymethylpyrimidine/ phosphopantothenate biosynthesis I -4-methylthiazole Pro superpathway of glycolysis and the Entner-Doudoroff pathway octanoyl-L-lysine acid--CoA ligase: demethylmenaquinone guanosine(34) 3-phosphate diphosphate ACP nicotinate-nucleotide-- synthase: a tRNA a [prolipoprotein]- 3-methyl-6-oxocyclohex- synthase: lipA 1-carboxylate hydroxy-4-methyl- kinase/FAD phosphomethylpyrimidine hydroxymethylpyrimidine/ acetyl-CoA C- E4664_RS06740 E4664_RS06740 methyltransferase/2- transglycosylase acyltransferase: reductase: dehydratase dimethylbenzimidazole pyrithiamine E4664_RS02310 hydroxyethylthiazole S-1,2-diacyl-sn- 1-ene-1-carboxyl-CoA lipoyl deaminase/D-cysteine 2-oxoglutarate synthetase: phosphoribosyltransferase: kinase: E4664_RS12905 kinase: thiM phosphomethylpyrimidine D-glucopyranose glyceryl-L-cysteine acyltransferase octanoate [+ 3 isozymes] [+ 3 isozymes] methoxy-6-polyprenyl- desulfhydrase: Tgt: tgt 1-[18-hydroxyoeoyl]-2-E4664_RS19470 E4664_RS13295 FabZ: fabZ aldolase: 3-methyl-2-oxobutanoate FadA: fadA synthase: lipA a [2-oxoglutarate a 2-methyl 1,4-benzoquinol a trans-tetracos- ribF cobT thiaminase 4-methyl-5-(2- kinase: E4664_RS12905 NaMN 6-phosphate E4664_RS13155 a queuosine 34 [18-hydroxy-lioleoyl]-sn a 2'- E4664_RS13305 E4664_RS07900 adenine ribotide HMP-PP thiamine phosphate glycerol long-chain fatty an unsulfurated 5'-deoxyadenosine met dehydrogenase AMP diphosphate branched AMP diphosphate linoleoyl-CoA methylase UbiE: ubiE guanine 2-enoyl-[acp] roseoflavin 3-methyl-2-oxobutanoate lipoprotein 6 II: tenA 2-methyladeninyl phosphooxyethyl) HMP-PP nicotinate-nicotinamide phenylalanine- decanoyl-CoA acid--CoA ligase: [sulfur carrier] E2 protein] N 2,3,4-saturated 2-oxobutanoate in tRNA -glycerol 3-phosphate deoxyribonucleoside pyruvate 5'-phosphate phosphate hydroxymethyltransferase: phe signal peptidase: 9-carboxy-6-methyl-3,7- menaquinol-4 4-amino-2-methyl-5- adenosylcobamide biosynthesis thiazole nucleotide -tRNA ligase: E4664_RS06740 -lipoyl-L-lysine fatty acyl-CoA 5'-diphosphate panB from adenosylcobinamide-GDP E4664_RS16675 acyl-CoA dioxononanoyl-CoA adenosylcobinamide- oxythiamine pyrimidinemethanol adenylyltransferase: pheT pheS [+ 3 isozymes] thiamine an L-phenylalanyl- dehydrogenase: GDP NAD salvage 2-methyladenine E4664_RS01895 Phe hydroxymethylpyrimidine/ 2-dehydropantoate [tRNA ] an (S-diacyl-sn- a lipoprotein E4664_RS07800 acetyl-CoA C- a 3-methyl- α ω an [amino group carrier a 1-alkyl-sn a protein-L- pathway III (to thiamine phosphate Phe octanoyl-CoA a [pyruvate , -9Z- 1-stearoyl- 5'-chloro-5'- ribazoletransferase: thiaminase phosphomethylpyrimidine nicotinate-nucleotide-- nicotinate adenine a tRNA glyceryl)-L-cysteinyl- 1-cis-vaccenoyl-sn- γ nicotinamide riboside) synthase: 5-methoxy-6-methylbenzimidazolyl signal peptide [+ 17 isozymes] acyltransferase dehydrogenase branched 2,3,4- octadecenedioate a stearoyl-[acp] sn-glycerol a purine deoxyadenosine protein]-C-terminal- - -glycerol 3- 3',5'-ADP methionine- E4664_RS07680 II: tenA kinase: E4664_RS12905 dimethylbenzimidazole dinucleotide [apolipoprotein] SAM a sulfurated [sulfur carrier] glycerol-3-phosphate Coα-[α-(adenin- E4664_RS02310 FadA: fadA E2 protein] N 6 - saturated fatty acid acyl-CoA 3-phosphate ribonucleoside pyrimidine/purine 1-acyl-sn-glycerol- (L-glutamyl)-L-glutamate phosphate 3'(2'),5'- (R)-S-oxide + phosphoribosyltransferase: adenosylcobamide biosynthesis glucose-6- long-chain fatty 1-acyl-sn-glycerol- 1-acyl-sn-glycerol- peptide- β NADP 5-(2-hydroxyethyl) 6-phospho apolipoprotein N- (2E)-dec-2-enoyl-CoA lipoyl synthetase: pyrimidine/purine nucleoside 9-yl)]-Co - HMP-P cobT from adenosylcobinamide-GDP NAD+ synthase: phosphate octanoyl-L-lysine acid--CoA ligase: 3-phosphate 3-phosphate acetylglutamate 3-phosphate bisphosphate methionine -4-methylthiazole β D-glucono- acyltransferase: lnt 7-carboxy-4-methyl- synthase: lipA E4664_RS13800 nucleoside phosphorylase: adenosylcobamide -alanine (R)-pantoate thiamine 5-methoxy-6- E4664_RS12740 isomerase: enol-CoA acetyl-CoA E4664_RS06740 acyltransferase: acyltransferase: kinase: argB acyltransferase: nucleotidase CysQ: (R)-S-oxide 2-methyladenine 1,5-lactone 5-oxoheptanoyl-CoA lipoyl phosphorylase: 5'-phosphate hydroxyethylthiazole hydroxymethylpyrimidine/ thiamine diphosphate phosphate methylbenzimidazole methionine- E4664_RS16405 an N-acyl-(S-diacyl- [+ 3 isozymes] [+ 3 isozymes] E4664_RS19470 E4664_RS15150 1-cis-vaccenoyl-E4664_RS19470 an [amino group carrier a 2-acyl-1-alkyl-E4664_RS19470 E4664_RS07920 reductase + nicotinate-nucleotide-- + met a peptide hydratase: a [pyruvate a 3-methyl- 1-stearoyl-2- E4664_RS15150 NAD phosphomethylpyrimidine ribotide phosphate NAD -tRNA sn-glyceryl)-L- synthase: lipA ω-carboxy- α 5-chloro-5- kinase: thiM thiamine- dimethylbenzimidazole an L-methionyl- E4664_RS01890 an unsulfurated dehydrogenase branched stearoyl-sn -D-ribose- 2-palmitoleoyl-sn- protein]-C-terminal- sn-glycerol MsrB: msrB kinase: E4664_RS12905 pantoate--beta-alanine ligase: metG cysteinyl-[lipoprotein] 5'-deoxyadenosine met diphosphate AMP AMP diphosphate (9Z)-octadec- acyl-carrier protein a purine base adenine deoxyribose γ AMP a [protein]-L- NAD(+) 4-methyl-5-(2- adenosylcobinamide- phosphate phosphoribosyltransferase: [elongator (S)-3- [sulfur carrier] E2 protein] N 6 2,3,4-saturated -glycerol 3- 1-phosphate glycerol-3-phosphate -(5-phospho-L- 3-phosphate Coα-[α-(adenin- phosphooxyethyl) ligase: E4664_RS13820 lipoate biosynthesis D-gluconate 9-enoyl-CoA 1-phosphate glutamyl)-L-glutamate methionine diphosphatase: HMP-PP GDP kinase: thiL 5-methoxy-6-cobT elongator tRNA Met ] hydroxydecanoyl-CoA (2E)-7-carboxy-4-methyl- -lipoyl-L-lysine fatty acyl-CoA phosphate β and incorporation Met 7-yl)]-Co - nudC thiazole ribazoletransferase: tRNA 6-phosphate 5-oxohept-2-enoyl-CoA adenosylcobamide 5-methoxybenzimidazolyl (R)-pantothenate thiamine methylbenzimidazole III (Bacillus) E4664_RS07680 phosphogluconate enol-CoA adenosylcobamide biosynthesis Coα-[α-(2- diphosphate ribotide phosphate 5-oxo-L-proline metabolism a reduced 1-stearoyl- a mature 3-oxo-2-(cis- 1402 DNA with adenine:7,8- 1-palmitoyl- 4-hydroxy- NMN thiamine an octanoyl-[acp] dehydratase: 16-hydroxypalmitate an acyl-[acyl- a (6S)-5- a cytidine digallate from adenosylcobinamide-GDP methyladenin-9-yl)]-Co adenosylcobinamide- hydratase: electron-transfer ubiquinone-6 sn-glycerol peptidoglycan glu 2'-pentenyl)- dihydro-8- sn-glycerol 4-methyl-2- phosphate pantothenate kinase: E4664_RS14325 carrier protein] (n) formyltetrahydrofolate in 16S rRNA β GDP lipoyl(octanoyl) a [protein] with a [protein] with 3-oxodecanoyl-CoA E4664_RS01890 long-chain fatty 16S rRNA oxoguanine mismatch 3-phosphate oxoglutarate tannase/feruloyl 5'-nucleotidase synthase: 5-methoxybenzimidazole E4664_RS13040 -adenosylcobamide lysine- F6P flavoprotein electron transfer 1-acyl-sn-glycerol-3-phosphate (meso-DAP bifunctional cyclopentane-1- A/G-specific 1-acyl-sn-glycerol- putative 4- ribazoletransferase: transferase a tRNA Lys an N-terminal an N-terminal (3R)-7-carboxy-3-hydroxy-4- acid--CoA ligase: lytic murein (cytidine(1402)-2'-O) esterase family lipoate biosynthesis SurE: E4664_RS02310 nicotinate-nucleotide-- 5'-phosphate a [glycine-cleavage -tRNA KDGP acetyl-CoA C- flavoprotein- 3-phosphate containing) tetrahydrofolate (3-oxooctanoyl) adenine 3-phosphate hydroxy-4-methyl- E4664_RS07680 LipB: lipB L-glutamine L-glutamate methyl-5-oxoheptanoyl-CoA E4664_RS06740 transglycosylase: acetyl-CoA C- -methyltransferase: alpha/beta and incorporation I E4664_RS02475 dimethylbenzimidazole (R)-4'-phosphopantothenate 5-hydroxybenzimidazolyl α α complex H protein] ligase: lysS acyltransferase ubiquinone acyltransferase: synthase/ -CoA glycosylase: acyltransferase: 2-oxoglutarate Co -[ -(5-methoxy-6- an L-lysyl- E4664_RS16775 acyltransferase rsmI hydrolase: bifunctional adenosylcobamide biosynthesis 6 [+ 3 isozymes] oxidoreductase: E4664_RS19470 3-oxo-2-(cis- mutY E4664_RS19470 thiamine phosphoribosyltransferase: methylbenzimidazolyl)]- N -octanoyl-L-lysine [tRNA Lys ] FadA: fadA a 1-stearoyl 2- GlcNAc-1,6- a mature dihydrofolate FadA: fadA a 2'-O- a 1-palmitoyl-2- aldolase: metallophosphatase/ α α from adenosylcobinamide-GDP bifunctional β-D-fructose 1,6- E4664_RS14885 [+ 3 isozymes] 2'-pentenyl)- 1402 E4664_RS11140 an octanoyl-[acp] phosphate cobT Co -[ -(2- Coβ-adenosylcobamide lys 16-hydroxypalmitoyl- an oxidized acyl-carrier protein acyl-sn-glycerol anhMurNAc- peptidoglycan synthase: folC acetyl-CoA methylcytidine an apurinic site acyl-sn-glycerol E4664_RS07900 5-methoxybenzimidazole 4-hydroxy-2- octanoyl-CoA AMP diphosphate (n) a (6S)-5- cyclopentane-1- adenine 5'-nucleotidase: glutathione- methyladenin-7-yl)]-Co 5-hydroxybenzimidazole NaMN 5'-phosphate bisphosphate a [protein] with 7-carboxy-4-methyl-3,5- CoA H + ubiquinol-6 electron-transfer 3-phosphate L-Ala-γ-D-Glu- (meso-DAP in 16S rRNA within DNA 3-phosphate pyruvate gallate lipoyl(octanoyl) ribotide phosphate thiamine oxoglutarate DHAP γ formyltetrahydrofolate hexanoyl-CoA E4664_RS07150 glutaredoxin β-adenosylcobamide nicotinate-nucleotide-- fructose- an N-terminal 5- -L-glutamyl dioxoheptanoyl-CoA flavoprotein DAP-D-Ala containing) transferase β folate polyglutamylation salvage I a [lipoyl-carrier protein] aldolase/2- glutathione acyl-CoA 1-( -D redox reactions adenosylcobinamide- dimethylbenzimidazole bisphosphate oxo-L-proline 5-phosphate a [lipoyl-carrier protein]LipB: lipB ribofuranosyl) N 6 -octanoyl-L-lysine dehydro-3-deoxy- triose-phosphate dehydrogenase: GDP ribazoletransferase: phosphoribosyltransferase: α α aldolase class II: acetyl-CoA C- 6 glutathione Co -[ -(5-methoxy-6- thiamine histidine- phosphogluconate E4664_RS07800 1-myristoyl- 3-oxo-2-(cis- 1402 1-myristoyl- a [lipoyl-carrier 6-O-trans- N -octanoyl-L-lysine nicotinamide E4664_RS07680 a tetrahydrofolate lipoyl his E4664_RS08435 isomerase: 18-hydroxystearate a 2,3,4-saturated a 2,3,4-saturated 2- a cytidine cobT methyl-benzimidazolyl)]- -tRNA aldolase: eda [+ 17 isozymes] acyltransferase a myristoyl-[acp] sn-glycerol a purine a purine 2'- 2'-pentenyl)- ethylphosphate sn-glycerol protein]-N 6 -[(R) methoxy-mycolyl- lipoyl menaquinol-7 biosynthesis α α 5-hydroxybenzimidazole synthase: lipA E4664_RS15115 fatty acyl-[acp] lysophosphatidate arsenate in 16S rRNA Co -[ -(5-methoxybenzimidazolyl)]- Coβ-adenosylcobamide ligase: hisS an L-histidyl- FadA: fadA long-chain fatty 3-phosphate ribonucleoside deoxyribonucleoside cyclopentane-1- 16S rRNA 3-phosphate -dihydrolipoyl]- trehalose 6- synthase: lipA β ribotide phosphate lipoyl 1-acyl-sn-glycerol- 1-acyl-sn-glycerol- pyrimidine/purine pyrimidine/purine acid phosphatase: 1-acyl-sn-glycerol- all-trans- a reduced Co -adenosylcobamide 5'-phosphate thiamine His (2E)-oct-2-enoyl-CoA acid--CoA ligase: (3-oxohexanoyl) (cytosine(1402)-N(4) L-lysine phosphate bifunctional serine synthase: lipA [tRNA ] D-glyceraldehyde 5-oxo-L-proline 3-phosphate 3-phosphate E4664_RS06965 3-phosphate dihydrolipoyl trehalose- lipoyl 1,4-dihydroxy- adenosylcobinamide- His 5-carboxy-2-methyl- nucleoside nucleoside acetyl-CoA C- heptaprenyl glutaredoxin tetrahydrofolate hydroxymethyltransferase: phosphate a tRNA acetyl-CoA E4664_RS06740 -CoA )-methyltransferase acyltransferase: dehydrogenase: synthase: lipA 2-naphthoate GDP ribazoletransferase: a [lipoyl-carrier 3-phosphate enol-CoA 3-oxopentanoyl-CoA acyltransferase: acyltransferase: phosphorylase: phosphorylase: acyltransferase alkaline phosphatase: diphosphate synthase/ E4664_RS03550 6 5-oxoprolinase/ [+ 3 isozymes] 3-oxo-2-(cis- 4 RsmH: rsmH E4664_RS19470 E4664_RS19525 a [lipoyl-carrier glutaredoxin a 10- E4664_RS07680 thiamine- protein]-N -[(R)- hydratase: E4664_RS19470a 2,3,4-saturated E4664_RS194701,2-dimyristoyl- E4664_RS15150 α E4664_RS15150 FadA: fadA an N - phosphatase: 1,2-dimyristoyl- trehalose-otsB 6 menaquinol-8 biosynthesis urea amidolyase 2-deoxy- - 2'-pentenyl)- 1402 a [lipoyl-carrier protein]-N -[(R)- demethylmenaquinol-7 α α dihydrofolate formyltetrahydrofolate phosphate dihydrolipoyl]-L-lysine E4664_RS01890 18-hydroxystearoyl- 1,2-diacyl-sn acyl-carrier protein sn-glycerol acetyl-CoA methylcytidine E4664_RS01335 sn-glycerol [+ 2 isozymes] 3: grxC Co -[ -(5-methoxybenzimidazolyl) Coα-[α-(5-hydroxybenzimidazolyl)]- AMP diphosphate ribose-1-arsenate a purine base D-ribose 1- a purine base 6 trans-methoxy- dihydrolipoyl]-L-lysine synthase: folC a 5,10- kinase: thiL family protein: CoA acyl-carrier protein cyclopentane- in 16S rRNA 3-phosphate protein]-N - a protein with ]-Coβ-adenosylcobamide bifunctional Coβ-adenosylcobamide 5'-phosphate (S)-3- -glycerol 3- 3-phosphate phosphate ethanol mono-mycolate bifunctional methylenetetrahydrofolate demethylmenaquinol-8 glycine-- E4664_RS10050 1-butanoyl-CoA lipoyl-L-lysine reduced L- tetrahydrofolate thiamine 13-DPG hydroxyoctanoyl-CoA succinyl-CoA propanoyl-CoA phosphate demethylmenaquinone bifunctional bifunctional tRNA ligase: cysteine residues a tetrahydrofolate synthase/ diphosphate gly glu methyltransferase/2- tetrahydrofolate demethylmenaquinone menaquinol-9 biosynthesis E4664_RS18820 dihydrofolate phosphoglycerate (R)-4'- 38- 1-palmitoyl- menaquinol-6 biosynthesis methoxy-6-polyprenyl- synthase/ glyQ DNA combined with 1-palmitoyl- a nucleoside 2-hydroxy-4-oxobutane- a 3,5,7,9,11,13,15- a uridine synthase: folC α α methyltransferase/2- Gly a ferrocytochrome ethanol a protein with guanylyl molybdenum Co -[ -(5-hydroxybenzimidazolyl) a glycyl-[tRNA ] kinase: pgk phosphopantothenoyl- exogenous DNA to form a palmitoyl-[acp] sn-glycerol stearoyl-CoA a ribonucleic acid 1,2,4-tricarboxylate hepta-oxo- 40 in tRNA sn-glycerol 1,4-benzoquinol dihydrofolate β methoxy-6-polyprenyl- b triphosphate a disulfide bond a 10- ]-Co -adenosylcobamide demethylmenaquinol-9 Gly 3-oxooctanoyl-CoA L-cysteine a recombinational junction 3-phosphate 5 putative 4- hexadecanoyl-[PKS-acp] tRNA 3-phosphate catalase/ methylase UbiE: ubiE cofactor biosynthesis synthase: folC 1,4-benzoquinol a tRNA 3-phospho- bifunctional Holliday junction 1-acyl-sn-glycerol- acyl-CoA DNA- 1-acyl-sn-glycerol- protein- demethylmenaquinol-6 bifunctional β aldo/keto peroxidase MoO - formyltetrahydrofolate D-glycerate fatty acid -oxidation I phosphopantothenoylcysteine resolvase RuvX: ruvX 3-phosphate desaturase: directed RNA hydroxy-4-methyl- pseudouridine(38- 3-phosphate disulfide 2 a 5,10- methylase UbiE: ubiE acetyl-CoA C- reductase: bifunctional menaquinol-7 demethylmenaquinone N 6 -L- E4664_RS16570 2-oxoglutarate 40) synthase acyltransferase: HPI: katG molybdopterin methylenetetrahydrofolate menaquinol-8 2,3-bisphosphoglycerate- acyltransferase decarboxylase/ crossover junction acyltransferase: polymerase: E4664_RS18090 reductase demethylmenaquinone methyltransferase/2- threonylcarbamoyladenosine 37 a (3Z)-alk-3- aldolase: TruA: truA catalase: cofactor molybdenum cofactor independent FadA: fadA phosphopantothenate-- endodeoxyribonuclease E4664_RS19470 [+ 3 isozymes] rpoC rpoB 9-hydroxy-3,5,7,11,13,15- 1-palmitoyl-E4664_RS19470 a protein withDsbD: dsbD methyltransferase/2- methoxy-6-polyprenyl- -modified tRNA biosynthesis enoyl-CoA dipalmitoyl a ferricytochrome E4664_RS07900 [+ 3 isozymes] E4664_RS07080 guanylyltransferase: methionine- phosphoglycerate cysteine ligase CoaBC: coaBC resolution of recombinationalRuvC: ruvC acyl-carrier protein oleoyl-CoA [+ 2 isozymes] hexaoxohexadecanoyl- 38- 2-myristoyl reduced L- methoxy-6-polyprenyl- guanylyl 1,4-benzoquinol met hexanoyl-CoA phosphatidate b oxaloacetate pyruvate a pseudouridine acetaldehyde E4664_RS05760 -tRNA mutase: 4'-phosphopantetheine junction formation 5 a ribonucleic acid [PKS-acp] phosphatidate cysteine residues 1,4-benzoquinol molybdenum methylase UbiE: ubiE thr 40 in tRNA ligase: metG E4664_RS15600 of two intact strands methylase UbiE: ubiE cofactor menaquinol-9 an L-methionyl- threonylcarbamoyl- acyl-CoA menaquinol-6 [initiator tRNA Met ] 2-phospho- AMP synthase: dehydrogenase: a trans-2- initiator tRNA Met E4664_RS07800 acyl-CoA enoyl-CoA 1-palmitoyl- D-glycerate E4664_RS12945 (15Z)- 1-cis-vaccenoyl- 1-palmitoyl- a [protein] N-terminal- a [protein]-L- sn-glycerol synthetase: a cis- sn-glycerol sn-glycerol MeOH phosphopyruvate threonylcarbamoyl- [+ 17 isozymes] a 2,3,4-saturated enol-CoA tetracosenoate a palmitoleoyl-[acp] sn-glycerol- sn-glycerol a stearoyl-[acp] formyl-L-methionine thr acyl-carrier protein proline (ω = 180) 3-phosphate coenzyme A E4664_RS13800 acyl-CoA vaccenoyl-[acp] 3-phosphate peptide 3-phosphate catalase/ hydratase: AMP synthase: hydratase: 1-acyl-sn-glycerol-3-phosphate 1-acyl-sn-glycerol-3-phosphate glycerol-3- FKBP-type 1-acyl-sn-glycerol- glycerol-3- superpathway of (Kdo) -lipid A biosynthesis Cell Structure Biosynthesis trans-hex-2-enoyl-CoA fatty acid acyl-CoA threonine ammonia- ACP S- 2 [+ 3 isozymes] a (3R)-3- synthetase: deformylase: def peptidyl-prolyl cis- peroxidase phosphate 1-O- peptidoglycan maturation (meso-diaminopimelate containing) E4664_RS06350 (L-threonylcarbamoyl)E4664_RS15965 dehydrogenase:E4664_RS01890 3-phosphate 3-phosphate phosphate 1-O- lyase: E4664_RS00700 3-phosphate hydroxyacyl-CoA E4664_RS13800 peptide malonyltransferase: trans isomerase: HPI: katG acyltransferase a (3R)-3- phosphoenol adenylate enol-CoA E4664_RS09405 a 2,3,4-saturated acyltransferase: acyltransferase: acyltransferase threonine ammonia- acyltransferase: lipid II (meso a 2,3,4-saturated [+ 3 isozymes] deformylase: fabD E4664_RS12310 catalase: PlsB: plsB UDP-N-acetyl- hydroxytetradecanoyl- pyruvate hydratase: [+ 17 isozymes] (3S)-3- E4664_RS194701-cis-vaccenoyl- E4664_RS194701-palmitoyl-2- PlsB:1-stearoyl- plsB lyase, biosynthetic: ilvA 1-palmitoyl-2-E4664_RS19470 1-oleoyl-sn diaminopimelate containing) fatty acyl CoA E4664_RS15950 [+ 9 isozymes] E4664_RS07080 α-D-glucosamine [acp] E4664_RS01890 hydroxyacyl-CoA (15Z)- 2-palmitoleoyl- acyl-carrier protein cis-vaccenoyl acyl-carrier protein sn-glycerol 2-oxobutanoate a malonyl-[acp] cis-vaccenoyl -glycerol 3- phosphoenolpyruvate AMP diphosphate acyl-carrier protein an N-terminal L- a [protein]-L- monofunctional (S)-3- tetracosenoyl-CoA sn-glycerol- phosphatidate 3-phosphate formate phosphatidate formaldehyde phosphate Aromatic Compound Biosynthesis synthase: ppsA an N 6 -L- methionyl-[protein] proline (ω = 0) biosynthetic hydroxyhexanoyl-CoA 3-phosphate threonylcarbamoyladenine 37 peptidoglycan pyruvate UDP-3-O-[(3R)-3- transglycosylase: enterobactin biosynthesis in tRNA D-ribulose 5-phosphate 4-hydroxyphenylpyruvate a 2,3,4-saturated acetyl-CoA C- a 2,3,4-saturated a long-chain 1-palmitoyl- (2S)- 527 hydroxymyristoyl]-N- mtgA adenosylcobinamide- phenyl ribotide a guanine + 1,6-anhydro-N- a 6,7- sn-glycerol biosynthesis 2,3,4-saturated sn-glycerol 3-phenyl-2- methylsuccinyl- acetyl-CoA NAD NADPH acetyl-α-D-glucosamine a nascent peptidoglycan fatty acyl CoA acyltransferase 3-oxoacyl-CoA GDP phosphate sn-glycerol a myristoyl-[acp] a myristoyl-[acp] tyr in 16S rRNA acetyl-β-muramate dihydropteridine 3-phosphate chorismate 3-oxohexanoyl-CoA fatty acid 3-phosphate oxopropanoate CoA 16S rRNA NAD(P)(+) anhydro-N- oxygen- UDP-3-O-acyl-N- with (L-alanyl-γ-D-glutamyl- FadA: fadA adenosylcobinamide- long-chain fatty 3-phosphate 1-acyl-sn-glycerol- glycerol-3- aspartate/ 3-oxoadipyl- glycerol-3- N-end rule pathway I (prokaryotic) (guanine(527)-N(7) transhydrogenase acetylmuramic insensitive acetylglucosamine meso-2,6-diaminopimeloyl-D- tyr GDP acid--CoA ligase: 3-phosphate phosphate 1-O- tyrosine/aromatic CoA thiolase: phosphate 1-O- Respiration acetyl-CoA C- )-methyltransferase (Re/Si-specific) acid kinase: NAD(P)H aldehydo-D-arabinose deacetylase: alanyl-D-alanine) pentapeptide aspartate/ ribazoletransferase: E4664_RS06740 acyltransferase: acyltransferase aminotransferase: E4664_RS09460 acyltransferase leucyl/phenylalanyl- acyltransferase RsmG: rsmG subunit beta: E4664_RS16950 nitroreductase: 5-phosphate E4664_RS17740 tyrosine/aromatic E4664_RS07680 [+ 3 isozymes] E4664_RS19470 PlsB: plsB E4664_RS16370 [+ 3 isozymes] an N 7 - N-acetyl-D- 1-palmitoyl-PlsB: plsB 2-oxoglutarate decarboxylation to succinyl-CoA tRNA--protein FadA: fadA phenyl-Coβ- a long-chain 1-palmitoyl- 1-myristoyl- 3-(4- 4-methyl-3- E4664_RS13905 nfsB UDP-3-O-(3- peptidoglycan biosynthesis I (meso-diaminopimelate containing) isochorismate aminotransferase: methylguanine 527 muramate 6- sn-glycerol transferase: acetyl-CoA GMP adenosylcobamide acyl-carrier protein 2-myristoyl acyl-carrier protein sn-glycerol phe hydroxyphenyl) a 5,6,7,8- hydroxymyristoyl) 3-(4- E4664_RS16370 a [protein] butanoyl-CoA AMP diphosphate 2,3,4-saturated oxoadipyl-CoA in 16S rRNA NADP + NADH phosphate 3-phosphate hydroxyphenyl) a [2-oxoglutarate an N-terminal E4664_RS12670 5'-phosphate fatty acyl CoA phosphatidate 3-phosphate pyruvate tetrahydropteridine -α-D-glucosamine UDP-N-acetyl-α-D-glucosamine a nascent peptidoglycan a nascent peptidoglycan a mature peptidoglycan with isochorismatase: N-terminal L- D-arabinofuranose UDP-3-O-(3- pyruvate dehydrogenase arginyl-[protein] acyl-CoA with (L-alanyl-γ-D-glutamyl- with D,D cross-links (meso- (L-alanyl-γ-D-glutamyl-meso- E4664_RS02320 6 leucyl-L-arginine 5-phosphate UDP-N-acetylglucosamine E2 protein] N 2-oxoglutarate dehydrogenase: hydroxymyristoyl) meso-2,6-diaminopimeloyl- diaminopimelate containing) 2,6-diaminopimeloyl-D-alanyl- acinetobactin glucosamine N- 1-carboxyvinyltransferase: -lipoyl-L-lysine dehydrogenase E4664_RS07800 1-cis-vaccenoyl- a guanine 966 a [protein]- 3-deoxy-8- D-alanine) tetrapeptide D-alanine) pentapeptide biosynthesis leucyl/phenylalanyl- Aromatic Compound Degradation 18-hydroxyoleate pentadecanoate a cis- sn-glycerol an alkylated DNA 3'-dephospho- H O acetyl-CoA acyltransferase: murA 2-oxoglutarate E1 component: [+ 17 isozymes] sn-glycerol- a palmitoyl-[acp] ATP in 16S rRNA 2 a lignoceroyl-[acp] biotin ATP L-histidine phosphooctulonate bifunctional tRNA--protein long-chain fatty long-chain fatty vaccenoyl-[acp] 3-phosphate DNA-3- CoA lpxD UDP-N-acetyl-α-D- dehydrogenase E4664_RS01185 1-acyl-sn-glycerol-3-phosphate glycerol-3- 16S rRNA acetyl-CoA heavy metal synthase: L,D-transpeptidase: L,D-transpeptidase: isochorismatase/ transferase: superpathway of acid--CoA ligase: acid--CoA ligase: methyladenine dephospho- enoyl-ACP UDP-2-N,3-O-bis[(3R)- glucosamine-enolpyruvate a mature peptidoglycan E1 component: crotonyl-CoA 4-sulfocatechol 3-phosphate phosphate 1-O- (guanine(966)-N(2) hydrolase/ biotin--[acetyl- sensor histidine E4664_RS06345 E4664_RS00615 E4664_RS00615 aryl carrier E4664_RS12670 a [protein] phenylethylamine benzoate degradation E4664_RS06740 E4664_RS06740 glycosylase: CoA kinase: reductase: 3-hydroxytetradecanoyl]- with D,D cross-links (meso- E4664_RS01185 an N-terminal acyltransferase: acyltransferase )-methyltransferase transferase CoA-carboxylase] kinase: UDP-N-acetylmuramate a nascent peptidoglycan with a mature peptidoglycan protein BasF: basF N-terminal L- enol-CoA degradation degradation I (aerobic) E4664_RS15135 E4664_RS14180 α glu diaminopimelate containing) L-lysyl-[protein] [+ 3 isozymes] [+ 3 isozymes] E4664_RS00485 2 RsmD: rsmD family protein: ligase: E4664_RS01500 KDO-8P -D-glucosamine dehydrogenase: murB a nascent peptidoglycan γ a nascent peptidoglycan γ [+ 3 isozymes]a [2-oxoglutarate a [2-oxoglutarate leucyl-L-lysine E4664_RS194701,2-dicis- PlsB:1-palmitoyl- plsB a DNA containing + an N - a [protein]- (L-alanyl- -D-glutamyl-meso- with (L-alanyl- -D-glutamyl- (2S,3S)-2,3- hydratase: an alkylated ADP coenzyme A H E4664_RS18260 a trans-tetracos- E4664_RS13035 UDP-2,3- with L,D cross links (meso- with (L-alanyl-γ-D-glutamyl- dehydrogenase dehydrogenase 2-phenylethylamine 4-sulfocatechol benzoate 18-hydroxyoleoyl- pentadecanoyl- an apurinic/ methylguanine 966 biotinyl-5'- N-phospho- glutamate 2,6-diaminopimelate) tripeptide meso-2,6-diaminopimeloyl- dihydroxy-2,3- E4664_RS01890 AMP diphosphate AMP diphosphate acyl-carrier protein vaccenoyl- acyl-carrier protein sn-glycerol nucleobase 2-enoyl-[acp] diacylglucosamine diaminopimelate containing) meso-2,6-diaminopimeloyl- E2 protein] N 6 E2 protein] N 6 -S- primary- protocatechuate benzoate 1,2- CoA CoA apyrimidinic site in 16S rRNA acetate adenylate L-histidine racemase: murI ala UDP-N-acetyl-α-D-muramate D-alanine) tetrapeptide dihydrobenzoate (S)-3- phosphatidate 3-phosphate diphosphatase: glycine) tetrapeptide -dihydrolipoyl- succinyldihydrolipoyl- amine 3,4-dioxygenase: dioxygenase: glutamate hydroxybutanoyl-CoA oxidase: pcaH pcaG benA benB E4664_RS05185 lipid IV biosynthesis (P. putida) L-lysine L-lysine 3,5-cyclohexadiene- α racemase: murI A a mature peptidoglycan with -Kdo UDP-N-acetylmuramate- tynA 3-sulfomuconate an [L-cysteine 1-arachidinoyl- a mature peptidoglycan γ 1,2-diol-1-carboxylate 32 a carboxy- 2552 a (3R)-3- lipid X -L-alanine ligase: murC (L-alanyl- -D-glutamyl-meso- 2,3- phenylacetaldehyde 7-hydroxylaurate pristanate a cytosine uridine a pimeloyl-[acp] D-glt with L,D cross-links (meso- a mature peptidoglycan a pimeloyl-[acp] ala desulfurase]-S- cys adenylated-[ThiS D-cysteine sn-glycerol hydroxydocosanoyl- a protein 3-deoxy-manno- a (3R)-3- UDP-N-acetyl- 2,6-diaminopimelate) tripeptide 1,6- in tRNA in 23S rRNA methyl ester UDP-N-acetyl-α-D-muramoyl-L-alanine γ dihydroxybenzoate [EntB aryl- long-chain fatty long-chain fatty sulfanyl-L-cysteine sulfur-carrier protein] 23S rRNA 3-phosphate octulosonate lipid-A- hydroxydecanoyl-[acp] α-D-glucosamine diaminopimelate containing) with (L-alanyl- -D-glutamyl- 2-oxoglutarate acetoacetyl-CoA NAD-dependent dihydroxycyclohexa- 8-amino-7- tRNA 2- cysteine 1-aminocyclopropane-1- 1-acyl-sn-glycerol- [acp] 3-hydroxyacyl- (2,3- carrier protein] [EntF L-seryl- acid--CoA ligase: acid--CoA ligase: (uridine(2552)-2'-O) enoyl-ACP cytidylyltransferase: disaccharide meso-2,6-diaminopimeloyl- ser dehydrogenase phenylacetaldehyde 2,4-diene-1- oxononanoate thiocytidine(32) desulfurase: carboxylate deaminase/D- 3-phosphate ACP metalloprotease: UDP-N-acetylmuramoyl- UDP-3-O-[(3R)-3- dihydroxybenzoyl) carrier protein] protocatechuate degradation E4664_RS06740 E4664_RS06740 -methyltransferase reductase: kdsB synthase: glycine) tetrapeptide E1 component: acetyl-CoA C- dehydrogenase: 4-sulfomuconolactone carboxylate synthase: synthetase E4664_RS09185 cysteine desulfhydrase: acyltransferase: dehydratase E4664_RS01245 L-alanine--D-glutamate hydroxydecanoyl]-N- adenylate II (ortho-cleavage pathway) RlmE: rlmE E4664_RS14180 E4664_RS07635 E4664_RS01185 acyltransferase E4664_RS06570 dehydrogenase: [+ 3 isozymes] [+ 3 isozymes] E4664_RS12975 TtcA:an [L-cysteinettcA a thiocarboxy- E4664_RS13155 a 2'-O- a 1-arachidonoyl-E4664_RS19470 FabZ: fabZ CMP-Kdo ligase: E4664_RS15535 acetyl-α-D-glucosamine synthase: entE a 2-thiocytosine 32 AMP ala an enoylpimeloyl- lipid A disaccharide FadA: fadA 7-hydroxylauroyl- 8-amino-7- desulfurase]- [ThiS-Protein] methyluridine 2552 2-acyl-sn-glycerol a (2E)-docos- a peptide UDP-3-O-acyl-N- (2,3- phenylacetate protocatechuate E4664_RS10425 AMP diphosphate AMP diphosphate pristanoyl-CoA acyl-carrier protein in tRNA pyruvate [acp] methyl ester (E. coli) a holo-[EntB aryl- [+ 2 isozymes] CoA oxononanoate L-cysteine in 23S rRNA 3-phosphate 2-enoyl-[acp] meso-diaminopimelate UDP-N-acetyl-α-D-muramoyl- acetylglucosamine dihydroxybenzoyl) a holo-[EntF protocatechuate tetraacyldisaccharide carrier protein] catechol L-alanyl-D-glutamate deacetylase: Secondary Metabolite Biosynthesis adenylate (L-seryl)adenylate L-seryl-carrier acetyl-CoA phenylacetate-- 3,4-dioxygenase: 2-maleylacetate 4'-kinase: E4664_RS17740 protein] CoA ligase: paaF pcaH pcaG quinate degradation I E4664_RS08380 D-ala UDP-N-acetylmuramoyl- UDP-3-O-(3- 3-carboxy-cis,cis-muconate 4-methylphenyl adenosylcobinamide- 2,3,6- 3-oxo-2-(cis- 3-oxo-2-(cis-2'-pentenyl) a (3R)-3- hydroxydecanoyl) methylerythritol adenosylcobinamide- α-ribazole glutathione a single a ribonucleoside -cyclopentane-1-(3R- an L-aspartyl- a (5Z)-dodec- L-alanyl-D-glutamate-- acinetobactin biosynthesis phenylacetyl-CoA ribotide trichlorohydroquinone 2'-pentenyl)- Asn hydroxyicosanoyl- a protein lipid IV (E. coli) phosphate pathway I baumannoferrin biosynthesis myo-inositol 3-carboxy- L-quinate GDP GDP stranded DNA triphosphate oxaloacetate ITP [tRNA ] 5-enoyl-[acp] A D-alanine--D-alanine 2, 6-diaminopimelate -α-D-glucosamine phosphate adenosylcobinamide- glutathione S- cyclopentane-1- hydroxybutanoyl)-CoA [acp] biosynthesis a 2,3- adenosylcobinamide- DNA primase: phosphoenolpyruvate Asp-tRNA(Asn) 3-hydroxyacyl- ligase: E4664_RS17720 ligase: E4664_RS18410 UDP-3-O-(3- D-glyceraldehyde Secondary Metabolite Degradation cis,cis-muconate anthranilate GDP transferase: (3-oxobutanoyl) enol-CoA enoyl-ACP pyruvate dihydroxybenzoyl- a seryl-[EntF 3-oxoadipate GDP E4664_RS12820 carboxykinase (GTP) /Glu-tRNA(Gln) ACP Lon protease: 3-deoxy-D-manno- hydroxymyristoyl) 3-phosphate L-aspartate 4- D-glucopyranose cycloisomerase: degradation ribazoletransferase: E4664_RS08750 -CoA acetyl-CoA C- hydratase: reductase: α ATP 2,3- [EntB aryl- L-seryl-carrier ribazoletransferase: DNA primase: : E4664_RS01380 amidotransferase: dehydratase E4664_RS11825 octulosonic acid D-alanyl-D-alanine UDP-N-acetyl- -D-muramoyl-L-alanyl- glucosamine N- semialdehyde 6-phosphate 2-(1,2-epoxy-1,2- E4664_RS06390 3-dehydroquinate I (aerobic) E4664_RS07680 [+ 6 isozymes] acyltransferase E4664_RS01890 E4664_RS14180 γ 1-deoxy-D-xylulose- dihydroxybenzoate carrier protein] protein] D-galactarate D-glucarate E4664_RS07680 2,6-dichloro-3- E4664_RS19750 phosphoenol 3-oxo-2-(cis-2'-pentenyl) gatB gatA gatC FabZ: fabZ transferase: -D-glutamyl-meso-2,6-diaminopimelate acyltransferase: ATP thr dihydrophenyl) (2-carboxy-2,5-dihydro- 4-methylphenyl-Co ssDNA/pppN(pN) IDP (+)-7-FadA:epi fadA- an L-asparaginyl- a (3E,5Z)-dodeca- 5-phosphate diaminobutyrate- degradation II degradation II anthranilate (glutathion-S-yl) pyruvate acetyl-CoA -cyclopentane-1-(E- a (2E)-icos- a peptide E4664_RS17830 lpxD (2,3- acetyl-CoA 5-oxofuran-2-yl)-acetate type II 3- GMP β-adenosylcobamide GMP adenosylcobalamin hybrid jasmonoyl-CoA [tRNA Asn ] 3,5-dienoyl-[acp] 2-enoyl-[acp] UDP-N-acetylmuramoyl- UDP-2-N-[(3R)-3- synthase: -2-oxoglutarate Ins(3)P anthranilate 1,2- -hydroquinone n -1 buta-2-enoyl)-CoA dihydroxybenzoyl) D-galactarate D-glucarate 2-(1,2-epoxy-1,2- 4-carboxymuconolactone dehydroquinate 5'-phosphate α-Kdo-(2->6)- tripeptide--D-alanyl-D- hydroxydodecanoyl]-3-O- E4664_RS18890 transaminase: adenylate dehydratase: aroQ dioxygenase: E4664_RS02370 an N-(2,3- galactarate glucarate dihydrophenyl) decarboxylase: antA antB lipid IV (E. coli) alanine ligase: murF [(3R)-3-hydroxydecanoyl]- 1-deoxy-D-xylulose synthase: entE inositol type I 3- A α dihydroxybenzoyl)- dehydratase: dehydratase: acetyl-CoA E4664_RS02875 catechol -D-glucosamine 5-phosphate L-2,4- (2,3- monophosphatase: dehydroquinate an [amino group carrier protein]- an (S)-2- 3-oxo-2-(cis-2'-pentenyl) an [RNA]-3'- a (3R,6Z)-3- UDP-N-acetyl-α-D-muramoyl-L- (L-threonyl) seryl-[EntF L-seryl- garD gudD isomerase: 4-carboxymuconolactone cob(II)alamin- γ wound RNA a glutaryl-[acp] UDP-2,3- diaminobutanoate dihydroxybenzoyl) E4664_RS18895 5-dehydro-4- 5-dehydro-4- methylmalonyl- C-terminal- -(L-glutamate 5- halocarboxylate pimeloyl-CoA ala -cyclopentane-1-(3R- ribonucleoside- hydroxyoctadec- a protein alanyl-γ-D-glutamyl-meso-2,6- 1-deoxy-D-xylulose- adenylate carrier protein] E4664_RS09655 decarboxylase: pcaC dehydratase: ATP [CblC-CblD ATP cob(II)inamide methyl ester di-trans,octa-cis-undecaprenyl phosphate diacylglucosamine adenylate deoxy-D-glucarate deoxy-D-glucarate CoA mutase semialdehyde-2-yl)-L-glutamateN-acetyl-gamma- HAD family ATP-dependent RNA hydroxyhexanoyl)-CoA 3'-phosphateRNA 3'-terminal 6-enoyl-[acp] α-Kdo-(2->4)-α-Kdo- diaminopimeloyl-D-alanyl-D-alanine 5-phosphate myo-inositol 2-oxepin-2(3H)- E4664_RS06420 complex] 8-amino-7- enol-CoA enoyl-ACP 3-hydroxyacyl- tail-specific diphosphatase: 5-dehydro-4- 5-dehydro-4- (4,5-dihydro-5- cob(I)yrinic acid cob(I)yrinic acid glutamyl-phosphate hydrolase: helicase RhlB: rhlB phosphate (2->6)-lipid IV (E. coli) reductoisomerase: ylideneacetyl-CoA oxononanoate hydratase: reductase: ACP protease: A E4664_RS05185 deoxyglucarate deoxyglucarate oxofuran-2-yl)-acetate 3-dehydroshikimate a,c-diamide a,c-diamide reductase: E4664_RS12900 ATP-dependent RNA cyclase: E4664_RS05930 synthase: E4664_RS01890 E4664_RS14180 dehydratase E4664_RS14280 dehydratase: dehydratase: 3-oxoadipate enol- chlorogenic adenosyltransferase: adenosyltransferase: E4664_RS06270 [+ 5 isozymes] helicase HrpA: hrpA 3-oxo-2-(cis-2'-pentenyl) E4664_RS03730 lauroyl LpxL/LpxP lipid X (P. putida) propane- a 2,3- an L-threonyl- enterobactin 3-dehydroshikimate an [amino group carrier protein]- an (S)-2- E4664_RS12975 an [RNA]-3'- a (2E,6Z)-FabZ: fabZ kdgD kdgD lactonase: pcaD acid degradation a [cobalamin E4664_RS00260 adenosylcobalamin- E4664_RS00260 γ a halide anion 8-amino-7- an unwound RNA an enoylglutaryl- acyltransferase: family Kdo(2)- undecaprenyldiphospho- MEP 1,3-diamine dihydroxybenzoyl- [L-threonyl- a [cyanocobalamin C-terminal- -(5-phospho- coenzyme A -cyclopentane-1-(E- ribunucleoside-2',3'- octadecadienoyl- a peptide 3-oxo-5,6- dehydratase: trafficking triphosphate [methylmalonyl- triphosphate adenosylcobinamide hydroxyarboxylate oxononanoate [acp] methyl ester E4664_RS10135 lipid IV(A) lauroyl/ N-acetylmuramoyl-L-alanyl- lipid-A- [aryl-carrier protein] carrier protein] 2,5- 2,5- 3-oxoadipate enol- trans-5-O- reductase CblC] L-glutamyl)-L-glutamate hexa-2-enoyl)-CoA cyclophosphate [acp] didehydrosuberyl- E4664_RS06425 protein CblD] CoA mutase] lipid A biosynthesis palmitoleoyl γ-D-glutamyl-meso-2,6- disaccharide 2-C-methyl-D- dioxopentanoate dioxopentanoate lactonase: pcaD caffeoyl-D-quinate erythritol 4-phosphate CoA semialdehyde protocatechuate lauroyl acyltransferase: diaminopimeloyl-D-alanyl-D-alanine synthase: 3-oxoadipate cytidylyltransferase: N-(3-aminopropyl) 1915 3-oxo-2-(cis-2'-pentenyl) 1-cis-vaccenoyl- acyltransferase: lpxL E4664_RS07635 trans-caffeate L-quinate cob(II)alamin- an apo-["base- a pseudouridine an (S)-2- long chain uridine sn-glycerol long chain undecaprenyldiphospho- E4664_RS06370 hydroxylamine -cyclopentane-1-(3R- sn-glycerol- E4664_RS01750 a 2,3- in 23S rRNA halocarboxylate an octanoyl-[acp] 3-phosphate polyphosphate muramoylpentapeptide beta-N- lipid A disaccharide (P. putida) 4-(cytidine 5'- ATP [CblC-CblD off/His-on" ATP cob(II)alamin HAD family polyphosphate pyrimidine/purine hydroxyoctanoyl)-CoA 3-phosphate Kdo -(palmitoleoyl) dihydroxybenzoyl-L- 2-oxoglutarate 2-oxoglutarate 3-oxo-5,6- 23S rRNA 1-acyl-sn-glycerol- glycerol-3- polyphosphate 2 acetylglucosaminyltransferase: catechol degradation complex] B12-enzyme] nucleoside enol-CoA enoyl-ACP α-Kdo-(2->4)-α- -lipid IV diphospho)-2-C- threonyl-[L-threonyl- didehydrosuberyl- cob(I)yrinic acid cob(I)yrinic acid (pseudouridine(1915)- hydrolase: 3-phosphate phosphate 1-O- kinase 1: ppk1 A murG tetraacyldisaccharide histamine to β-ketoadipate exopolyphosphatase: ppx phosphorylase: hydratase: reductase: Kdo-(2->6)-(lauroyl) methyl-D-erythritol carrier protein] CoA urate conversion to allantoin II a,c-diamide a,c-diamide N(3))-methyltransferase E4664_RS12900 acyltransferase: acyltransferase polyphosphate 4'-kinase: 4-(cytidine 5'- N 3 -dec-2-enoyl- N 3 -decanoyl-N adenosyltransferase: E4664_RS15150 E4664_RS01890 E4664_RS14180 -lipid IV (E. coli) lipid II (meso diaminopimelate containing) putative histamine adenosyltransferase: 3 RlmH: rlmH [+ 6 isozymes] 3-oxo-2-(cis-2'-pentenyl) E4664_RS19470 α ωPlsB: plsB kinase 1: ppk1 A E4664_RS08380 3 3 catechol an N - α 1,2-dicis- 1-C16:0- , - diphospho) N -hydroxy-1,3- -hydroxy-1,3- a [cobalamin E4664_RS00260 a holo-["base- E4664_RS00260 a (2R)-2- long chain -D-ribose- a (2E)-oct- long chain (Kdo) -lipid N-monooxygenase: urate a [cyanocobalamin methylpseudouridine 1915 a halide anion uracil -cyclopentane-1-(E- vaccenoyl- dicarboxyl-2- 2 -2-C-methyl- diaminopropane diaminopropane catechol 1,2- hydroxy fatty acid polyphosphate 1-phosphate lipid IV (P. putida) basC FAD-dependent trafficking triphosphate off/His-on" triphosphate adenosylcobalamin octa-2-enoyl)-CoA 2-enoyl-[acp] polyphosphate A, cold adapted A preQ biosynthesis dioxygenase: catA reductase CblC] in 23S rRNA phosphatidate lysophosphatidate D-erythritol a 2,3-dihydroxybenzoylmethyloxazolinyl- 0 trans-2,3- protein CblD] B12-enzyme] α-D-Kdo-(2->4) urate hydroxylase kinase: ispE N-hydroxyhistamine [L-threonyl-carrier protein] dehydroadipyl-coA cis,cis-muconate -α-D-Kdo-(2->6) 2-phospho-4-(cytidine HpxO: hpxO N 1 -citryl-N 3 - N 1 -citryl-N 3 - enol-CoA -lipid A (E. coli) muconate (S)-5-hydroxyisourate a [glycine-cleavage an (R)-2- an (R)-2- a cytosine 967 a nucleoside a cytidine 34 6-O-trans-keto- 5'-diphospho)-2-C- 3 GTP hydratase: a nucleoside a DNA segment dec-2-enoyl-N decanoyl-N - cycloisomerase: SAM complex H protein] a sulfurated [sulfur carrier] cob(II)yrinate halocarboxylate halocarboxylate in 16S rRNA cyclic 3',5'- in tRNA a malonyl-[acp] mycolyl-trehalose methyl-D-erythritol 3 GTP E4664_RS01890 ATP triphosphate -hydroxy-1,3- hydroxy-1,3- hydroxyisourate N 6 -octanoyl-L-lysine a,c-diamide HAD family HAD family 16S rRNA monophosphate tRNA (cytidine(34) recombinase: 6-phosphate 2-C-methyl-D- (3S)- E4664_RS06610 lipoyl nucleoside triphosphate diaminopropane diaminopropane cyclohydrolase hydrolase: uraH hydrolase: hydrolase: 3',5'-cyclic-nucleotide beta-ketoacyl- E4664_RS01040 trehalose- erythritol 2,4- 7,8- synthase: lipA cob(I)yrinic acid (cytosine(967)-C(5) -2'-O)- pre-acinetobactin I FolE: folE hydroxyadipyl- (+)-muconolactone hydroxyisourate E4664_RS12900 pyrophosphohydrolase: phosphodiesterase: ACP synthase II: phosphatase: dihydroneopterin lipoyl a,c-diamide E4664_RS12900 )-methyltransferase methyltransferase: recombinase cyclodiphosphate CoA hydrolase: uraH mazG E4664_RS01390 E4664_RS12720 otsB 3'-triphosphate synthase: lipA adenosyltransferase: [+ 5 isozymes] [+ 5 isozymes] RsmB: rsmB E4664_RS01085 RecA: recA trehalose- Fatty Acid and Lipid Biosynthesis synthase: ispF a [glycine-cleavage an (S)-2- a (2R)-2- a nucleoside 5'- a 5-methylcytosine 967 a 2'-O- a 3- a DNA segment 5 5 muconolactone Delta- (S)-2-oxo-4-hydroxy-4- an unsulfurated E4664_RS00260 a nucleoside 5'- N -2,4- N -2,4- adenosyl-cob(III) a halide anion a halide anion methylcytidine 34 oxodocosanoyl- in reverse trans-keto- 2-C-methyl-D-erythritol- 6-carboxytetrahydropterin isomerase: catC 5'-deoxyadenosine met complex H protein] triphosphate hydroxyarboxylate hydroxy fatty acid monophosphate in 16S rRNA monophosphate diaminobutanoate- carboxy-5-ureidoimidazoline [sulfur carrier] 6 mono-mycolate palmitate biosynthesis II 2,4-cyclodiphosphate diaminobutanoate- synthase: E4664_RS08330 N -lipoyl-L-lysine yrinate a,c-diamide in tRNA [acp] orientation palmitoleate phosphatidylglycerol phosphatidylserine and N 1 -citryl-N 3 -dec-2- N 1 -citryl-N 3 - (4,5-dihydro-5- 2-oxo-4-hydroxy- (bacteria and plant cytoplasm) acinetobactin 6-carboxy-5,6,7,8- 3-oxoadipyl-CoA biosynthesis I (from biosynthesis II (non-plastidic) phosphatidylethanolamine flavodoxin- enoyl-N 3 -hydroxy- decanoyl-N 3 - oxofuran-2-yl)-acetate 4-carboxy-5- tetrahydropterin (5Z)-dodec-5-enoate) biosynthesis I dependent 1,3-diaminopropane hydroxy-1,3- 3-oxoadipyl- 3-oxoadipate enol- ureidoimidazoline 1-stearoyl- 6-O-cis-methoxy- Carbohydrate Biosynthesis (1S,2R)-1-C-(indol-3- a cis,cis-delta5,23- + a 1-acyl-2-arachidonoyl- a 1-phosphatidyl- sn-glycerol an acetoacetyl-[acp] DHAP (E)-4-hydroxy- 7-carboxy-7- decarboxylase: uraD ser an oleoyl-[acp] sn-glycerol a malonyl-[acp] hydrogencarbonate H uroporphyrinogen-III a dodecanoyl-[acp] a cerotoyl-[acp] mycolyl-trehalose a (5Z)-dodec- a CDP-diacylglycerol diaminopropane CoA thiolase: lactonase: pcaD yl)glycerol 3-phosphate C42:2-[acp] phosphatidylinositol 1D-myo-inositol 3-phosphate NAD(P)H- 3-methylbut- deazaguanine E4664_RS09460 tryptophan synthase 3-phosphate carbonic anhydrase: glycerol-3- 6-phosphate 5-enoyl-[acp]beta-ketoacyl- CDP-diacylglycerol--serine gluconeogenesis I 3-oxoadipate enol- (S)-(+)-allantoin 1-acyl-sn-glycerol- beta-ketoacyl- phosphatidylinositol uroporphyrinogen-III phosphatidylinositol enoyl-ACP enoyl-ACP trehalose- dependent 2-enyl- synthase α subunit beta: trpB E4664_RS09630 phosphate 1-O- ACP synthase II: O-phosphatidyltransferase: UDP- -D-glucose PRPP biosynthesis [+ 3 isozymes] lactonase: pcaD 3-phosphate ACP synthase II: kinase: C-methyltransferase: kinase: reductase: reductase: phosphatase: glycerol-3- diphosphate baumannoferrin A QueE: queE biosynthesis I tryptophan synthase acyltransferase: E4664_RS12720 carbonic anhydrase: E4664_RS19970 cobA E4664_RS19970 acyltransferase a (7Z)-3-E4664_RS12720 pssA Metabolic Regulator a cis,cis- E4664_RS14180 E4664_RS14180 otsB a (3R)-3- phosphate a 3-sn-phosphatidyl- synthase: ispG 7-carboxy-7- (S)-malate D-ribose 5- succinyl-CoA 3-oxoadipate subunit beta: trpB E4664_RS19470 E4664_RS12080 a 1-acyl-2-arachidonoyl- a 1-phosphatidyl- PlsB: plsB trehalose- oxotetradec- Biosynthesis baumannoferrin B D-glucopyranose 1-stearoyl-2- acyl-carrier protein delta7,25-3- 1-arachidinoyl- hydroxybutanoyl- dehydrogenase: L-serine (E)-4-hydroxy-3- deazaguanine H O CO phosphatidylinositol precorrin-2 1D-myo-inositol a (2E)-dodec- a trans-hexacos- phosphate D-glyceraldehyde 3-phosphate trp acyl-carrier protein oleoyl-sn-glycerol oxo-C44:2-[acp] 2 2 sn-glycerol cis-methoxy- 7-enoyl-[acp] E4664_RS03820 methylbut-2-en- 6-phosphate ribose-phosphate 4-phosphate 4-phosphate 2-enoyl-[acp] 2-enoyl-[acp] [acp] phosphatidylserine ppGpp biosynthesis 7-cyano-7- phosphomannomutase/ 3-phosphate 3-phosphate mono-mycolate 3-hydroxyacyl- sn-glycerol 1-yl diphosphate phosphoglucomutase: pyrophosphokinase: 3-phosphate decarboxylase: psd deazaguanine E4664_RS12865 ACP synthase NAD-dependent NAD-dependent E4664_RS16395 a (3R,7Z)-3- an L-1- pppGpp malic enzyme: ribose-phosphate undecaprenyl-diphospho-N a (2E,5Z)- dehydratase glycerol-3- QueC: queC malic enzyme: phosphomannomutase/ Carbohydrate Degradation a cis- sn-glycerol a cis,cis-delta3,21- dehydro(indole- an insertion sequence hydroxytetradec- phosphatidylethanolamine E4664_RS16085 pyrophosphokinase: -acetylmuramoyl-L-alanyl-γ- UDP-N-acetyl-α-D-glucosamine a malonyl-[acp] glutathione monochlorobimane glutathione L-cystathionine an arachidoyl-[acp] a decanoyl-[acp] tetradeca-2,5- histidinol FabZ: fabZ phosphate 1-O- E4664_RS16085 phosphoglucomutase: vaccenoyl-[acp] 3-phosphate C40:2-[acp] 3-yl)acetonitrile element IS30 7-enoyl-[acp] preQ E4664_RS06915 D-glutamyl-L-lysyl- D-alanine glutathione S- glutathione S- dienoyl-[acp] acyltransferase 0 E4664_RS12605 undecaprenyldiphospho- glycerol-3- beta-ketoacyl- cystathionine transposase: histidinol a (2E)-but- bifunctional (p)ppGpp DMAPP IPP α-D-glucopyranose Entner-Doudoroff pathway I enoyl-ACP enoyl-ACP enoyl-ACP PlsB: plsB PRPP chitin degradation II (Vibrio) muramoylpentapeptide beta-N- phosphate 1-O- ACP synthase II: transferase: transferase: beta-lyase: E4664_RS10340 dehydrogenase: 2-enoyl-[acp] synthetase/guanosine- 1-phosphate D-galactose degradation I (Leloir pathway) reductase: reductase: reductase: a 1-acyl-sn pyruvate acetylglucosaminyltransferase: E4664_RS12720 E4664_RS08750 E4664_RS08750 E4664_RS19010 hisD 3',5'-bis(diphosphate) 3'- D-glucopyranose acyltransferase a cis,cis- [+ 2 isozymes] E4664_RS14180 E4664_RS14180 E4664_RS14180 enoyl-ACP a (2E,7Z)- -glycerol 3- long-chain fatty oxaloacetate UTP--glucose- β-D- murG PlsB: plsB [+ 6 isozymes] [+ 6 isozymes] an insertion pyrophosphohydrolase: 6-phosphate chitin ditrans,octacis-undecaprenyldiphospho- 1-cis-vaccenoyl- acyl-carrier protein delta5,23-3- (glutathion- (glutathion-S-yl)(1H- pyruvate L-homocysteine reductase: tetradeca-2,7- phosphate acid activation 1-phosphate galactopyranose sequence IS30 with a (2E)-icos- a (2E)-dec- a (5Z)-tetradec- his 1-acyl-sn-glycerol- E4664_RS13855 phosphoenolpyruvate UDP N-acetyl-(N-acetylglucosaminyl)muramoyl- acyl-carrier protein sn-glycerol- oxo-C42:2-[acp] S-yl)-bimane indol-3-yl)acetonitrile E4664_RS14180 dienoyl-[acp] Hormone Biosynthesis uridylyltransferase galactose γ integrated transposon 2-enoyl-[acp] 2-enoyl-[acp] 5-enoyl-[acp] Mg 2+ RS05415 Mg 2+ 3-phosphate a long-chain synthase: ppsA L-alanyl- -D-glutamyl-L-lysyl-D-alanine 3-phosphate enoyl-ACP bifunctional (p)ppGpp GalU: galU mutarotase: a butanoyl-[acp] acyltransferase: fatty acid synthetase/guanosine- 6-phospho reductase: acyl-CoA indole-3-acetate α E4664_RS12175 E4664_RS19470 phosphoenol UDP- -D-glucose a chitodextrin 2503 a cis,cis- 3 an N-terminal- a 5,6- a (2E,7Z)- E4664_RS14180 synthetase: 3',5'-bis(diphosphate) 3'- D-glucono- α-D- adenine an L-phenylalanyl- an N-terminal an N -methyladenine 1-chloro-2,4- pyridoxamine beta-ketoacyl- a 1,2-diacyl- biosynthesis pyruvate glutathione L-methionyl-L- glutathione RX dihydrouracil 20 pyrophosphohydrolase: 1,5-lactone in 23S rRNA Phe delta17,29- a malonyl-[acp] in DNA dinitrobenzene hexadeca-2,7- a butanoyl-[acp] ACP synthase II: a (7Z)-tetradec- sn-glycerol E4664_RS13800 IV (bacteria) galactopyranose [tRNA ] arginyl-[protein] 5'-phosphate E4664_RS18540 phosphopyruvate α 23S rRNA leucyl/phenylalanyl- C48:2-[acp] beta-ketoacyl- DNA-3- glutathione S- seryl-[protein]type I methionyl glutathione S- in tRNA dienoyl-[acp] E4664_RS12720 7-enoyl-[acp] 3-phosphate [+ 3 isozymes] (indole-3-yl) UDP- -D- tRNA enoyl-ACP enoyl-ACP pyridoxamine a long-chain hydratase: (adenine(2503)-C(2) tRNA--protein ACP synthase II: methyladenine transferase: aminopeptidase: transferase: phosphatidate acetonitrile galactose dihydrouridine(20/ reductase: reductase: 5'-phosphate a 3-oxohexanoyl- beta-ketoacyl- acyl-CoA E4664_RS06350 )-methyltransferase glycosylase I: E4664_RS08750 E4664_RS08750 cytidylyltransferase: UDP-N-acetyl-D- biosynthesis a chitodextrin transferase: E4664_RS12720a cis,cis- map 20a) synthase E4664_RS14180 E4664_RS14180 oxidase: pdxH [acp] ACP synthase II: GTP ppGpp 2-phospho- D-gluconate α-D-galactose RlmN: rlmN E4664_RS12670 E4664_RS17125 [+ 6 isozymes] an N-terminal [+ 6 isozymes] glucosamine biosynthesis I α α 2503 acyl-carrier protein delta19,31-3- met DusA: dusA E4664_RS05925 (indol-3-yl) UDP- -D-glucose 6-phosphate UDP- -D-glucose a 2-methyladenine L-phenylalanyl-L- an apurinic site 2,4-dinitrophenyl- L-seryl-[protein] a glutathione- a (7Z)-hexadec- a (2E)-but- E4664_RS12720 D-glycerate 1-phosphate 5'-deoxyadenosine met Phe 3-methyladenine HX 20 PLP a (9Z)-3- a CDP- acetamide D-glucopyranose UDP-glucose in 23S rRNA a tRNA oxo-C50:2-[acp] within DNA S-glutathione S-conjugate a uracil in tRNA 7-enoyl-[acp] 2-enoyl-[acp] 2,3-bisphosphoglycerate- phosphogluconate arginyl-[protein] oxohexadec- diacylglycerol 6-phosphate 4-epimerase bifunctional (p)ppGpp amidase: independent glucose-6- dehydratase: 9-enoyl-[acp] GalE: galE a (3R)-3- CDP-diacylglycerol-- nucleoside- synthetase/guanosine- E4664_RS06510 phosphoglycerate phosphate E4664_RS14325 UDP-glucose beta-N- decaprenyl-diphospho-N- UDP-N-acetyl- a cis,cis- a 1-acyl-2- S-(4-oxo-2- hydroxyhexanoyl- glycerol-3-phosphate 3- diphosphate 3',5'-bis(diphosphate) 3'- mutase: isomerase: an L-phenylalanyl- an N-terminal glutathione methylmercury glutathione fenclorim NADH DNA with lesion acetylhexosaminidase: acetylmuramoyl-pentapeptide α-D-glucosamine delta15,27- a malonyl-[acp] arachidonoyl- methylpentan- a behenoyl-[acp] a myristoyl-[acp] [acp] phosphatidyltransferase: kinase: pyrophosphohydrolase: (indol-3-yl)acetate E4664_RS16405 4-epimerase KDGP [tRNA Phe ] L-lysyl-[protein] CTP E4664_RS15600 N,N'- nagZ N,N',N''- undecaprenyldiphospho- glutathione S- glutathione S- NAD(+) excinuclease 3-hydroxyacyl- a (3R,9Z)-3- pgsA E4664_RS13855 GalE: galE leucyl/phenylalanyl- C46:2-[acp] beta-ketoacyl- sn-glycerol 2-yl)-L-cysteinecystathionine E4664_RS14260 3-phospho- F6P α muramoylpentapeptide beta-N- transferase: transferase: diphosphatase: enoyl-ACP enoyl-ACP ABC subunit ACP hydroxyhexadec- 1-(3-sn- UDP- -D-galactose UDP- diacetylchitobiose triacetylchitotriose tRNA--protein ACP synthase II: 3-phosphatephosphatidate beta-lyase: bifunctional (p)ppGpp Amine and D-glycerate bifunctional glucose 4- acetylglucosaminyltransferase: cytidylyltransferase: E4664_RS08750 E4664_RS08750 nudC reductase: reductase: UvrC: uvrC dehydratase 9-enoyl-[acp] phosphatidyl) glutamine-- beta-N- transferase: E4664_RS12720a cis,cis- 4-methyl-4-E4664_RS19010 synthetase/guanosine- Polyamine 4-hydroxy-2- epimerase murG a CDP-1-acyl-E4664_RS05925 reduced β- E4664_RS14180 E4664_RS14180 FabZ: fabZ -sn-glycerol phosphoglycerate fructose-6- acetylhexosaminidase: decaprenyl-pyrophosphoryl- E4664_RS12670 acyl-carrier protein delta17,29-3- [+ 6 isozymes] pyruvate sulfanylpentan- [+ 6 isozymes] [+ 2 isozymes] 3',5'-bis(diphosphate) 3'- Biosynthesis oxoglutarate GalE: galE L-phenylalanyl- 2-arachidonoyl- methylmercury- 4-(glutathion- nicotinamide D- AMP a (2E)-docos- a (2E)-tetradec- DNA without 3-phosphate kinase: pgk phosphate nagZ Phe a (2E)-hex- pyrophosphohydrolase: UDP (N-acetylglucosamine)-N- a tRNA oxo-C48:2-[acp] S-glutatione 2-one S-yl)-fenclorim ribonucleotide lesion histamine transaminase aldolase/2- UDP- N-acetyl-D- L-lysyl-[protein] glycerol 2-enoyl-[acp] 2-enoyl-[acp] 2-enoyl-[acp] a (2E,9Z)- phosphatidylglycerophosphatase E4664_RS18540 acetylmuramyl-(pentapeptide) biosynthesis (isomerizing) dehydro-3-deoxy- glucosamine hexadeca-2,9- A: E4664_RS17385 13-DPG glucose 4- enoyl-ACP : glmS phosphogluconate epimerase dienoyl-[acp] an L-1- an N 6 -L- a peptidoglycan reductase: his aldolase: eda GalE: galE a cis,cis- (3Z)-hex- (2E)-tetradec- an (2E,11Z) dCDP enoyl-ACP phosphatidyl- GDP triose-phosphate D-glucosamine threonylcarbamoyladenine 37 2-methylbutanoate dimer (generic) 2-oxoglutarate an unsulfurated glutathione E4664_RS14180 histidine delta13,25- a malonyl-[acp] cys 3-en-1-ol 2-enoyl-CoA a hexanoyl-[acp] -icosa-2,11- ribonucleoside- reductase: sn-glycerol isomerase: 6-phosphate in tRNA acetate- lytic murein 2-oxoglutarate [sulfur carrier] glutathione S- decarboxylase: D-glyceraldehyde C44:2-[acp] beta-ketoacyl- cysteine enol-CoA dienoyl-[acp] diphosphate a hexanoyl-[acp] E4664_RS14180 biotin-carboxyl carrier E4664_RS15115 D-glyceraldehyde phosphoglucosamine pyruvate tRNA -CoA transglycosylase: dehydrogenase transferase: enoyl-ACP enoyl-ACP E4664_RS02655 DHAP 3-phosphate threonylcarbamoyladenosine ACP synthase II: E4664_RS16775 desulfurase: hydratase: reductase: reductase: reductase: protein assembly histamine 3-phosphate mutase: glmM ligase: acs E4664_RS12720 E1 component: E4664_RS09185 E4664_RS08750 E4664_RS01890 beta-ketoacyl- a palmitoleoyl-[acp] dehydratase: E4664_RS13955 a cis,cis- [+ 3 isozymes] E4664_RS14180 E4664_RS14180 E4664_RS13295 α-D-glucosamine a cyclic N 6 -L- 2-methylbutanoyl- E4664_RS01185 a sulfurated [+ 6 isozymes] (S)-3- a [biotin carboxyl- AMP diphosphate acyl-carrier protein delta15,27-3- GlcNAc-1,6-anhydro- ala 3-(glutathion-S E4664_RS13305 ACP synthase II: 1-phosphate threonylcarbamoyladenosine CoA a lipid II NADH CO succinyl-CoA [sulfur carrier] hydroxytetradecanoyl- a (2E)-hex- carrier protein]-L-lysine trehalose biosynthesis I α-D- oxo-C46:2-[acp] MurNAc-pentapeptide 2 a gondoyl-[acp] E4664_RS12720 stearate biosynthesis UDP-α-D- -yl)-hexan-1-ol CoA 2-enoyl-[acp] CDP II (bacteria and plants) biotin--[acetyl- fructose- UDP-N- 13-DPG glucopyranose 37 in tRNA a 3-oxooctanoyl- bisphosphate galactose CoA-carboxylase] acetylglucosamine D-glucopyranose α 1-phosphate [acp] aldolase class II: UDP- -D-glucose palmitoleate a palmitoyl-[acp] ligase: diphosphorylase/ 6-phosphate phosphoglycerate 2,3,5,6- a cis,cis- UDP E4664_RS08435 trehalose-6- phosphomannomutase/ a single glutathione 3-phenyl-2- a 23S rRNA a double carbonic acid 2,2-dichloroacetate E4664_RS13035 glucosamine-1- 1911/1915/1917 phosphate kinase: pgk phosphoglucomutase: stranded DNA tetrachlorohydroquinone delta11,23- a malonyl-[acp] oxopropanoate uridine stranded DNA a palmitoyl-[acp] Hyp ribonucleoside- a [biotin carboxyl- phosphate N- exodeoxyribonuclease glutathione S- 23S rRNA carbonic anhydrase: glutathione S- synthase: 3-phospho- E4664_RS16395 C42:2-[acp] beta-ketoacyl- diphosphate carrier protein]-N acetyltransferase: VII large subunit: transferase: 4-hydroxyphenylpyruvate pseudouridine(1911/ exo: recD E4664_RS09630 transferase: enoyl-ACP 4-hydroxyproline a (3R)-3- a 3-oxooctadecanoyl- E4664_RS12995 D-glycerate ACP synthase II: reductase: 6 -biotinyl-L-lysine β glmU α,α-trehalose phosphomannomutase/ dioxygenase: hppD E4664_RS14985 reductase: epimerase: hydroxyoctanoyl- [acp] -D-fructose 1,6- E4664_RS10350 E4664_RS08750 E4664_RS12720 1915/1917) carbonic anhydrase: E4664_RS08750 N-acetyl-α-D- 6-phosphate phosphoglucomutase: a cis,cis- E4664_RS14180 E4664_RS09735 E4664_RS13295 [acp] bisphosphate [+ 3 isozymes] [+ 6 isozymes] (2-hydroxyphenyl) synthase RluD: rluD E4664_RS12080 [+ 6 isozymes] glucosamine trehalose- E4664_RS12605 2,3,5-trichloro-6-(glutathion- acyl-carrier protein delta13,25-3- a pseudouridine 1911/ a 5'-phosphooligonucleotide E4664_RS13305 3-hydroxyacyl- a single-stranded a ribonucleoside acetate CO H O glyoxylate a (2E)-hexadec- cis-4-hydroxy- 1-phosphate phosphatase: S-yl)-hydroquinone oxo-C44:2-[acp] 1915/1917 in 23S rRNA 2 2 dUDP ACP a [biotin carboxyl- 2-phospho- D-glucopyranose oligodeoxyribonucleotide 5'-monophosphate 2-enoyl-[acp] D-proline otsB dehydratase a (3R)-3- carrier-protein dimer]- UDP-N- D-glycerate 6-phosphate 6 FabZ: fabZ hydroxyoctadecanoyl- N -biotinyl-L-lysine F6P acetylglucosamine α,α-trehalose phosphopyruvate 2,5-diamino-6-(5- a 5-carboxymethylaminomethyluridine 34 an N-terminal- a uracil 1939 (11Z)- a (2E,9Z)- an organic [acp] acetyl-CoA diphosphorylase/ hydratase: a cis,cis-delta9,21- a (4Z)-hexadec- 2-oxoadipate [DNA] a (2E)-oct- 3-hydroxyacyl- glucose-6- glucosamine-1- phospho-D-ribitylamino) in tRNA Leu a malonyl-[acp] a malonyl-[acp] L-methionyl-L- in 23S rRNA hexadecenoyl-CoA octadeca-2,9- hydroperoxide carboxylase E4664_RS06350 pyrimidin-4(3H)-one C40:2-[acp] 4-enoyl-[acp] acyl-CoA DNA polymerase 2-enoyl-[acp] ACP phosphate phosphate N- fructose degradation bifunctional tRNA (cytidine(34) beta-ketoacyl- beta-ketoacyl- 2-oxoglutarate alanyl-[protein]type I methionyl 23S rRNA dienoyl-[acp] alkyl carboxyltransferase phosphoenol dehydrogenase: III subunit enoyl-ACP enoyl-ACP dehydratase acetyl-CoA isomerase: acetyltransferase: diaminohydroxyphosphoribosylaminopyrimidine -2'-O)- ACP synthase II: ACP synthase II: dehydrogenase aminopeptidase: (uracil(1939)-C(5)) hydroperoxide subunit alpha: pyruvate E4664_RS07800 epsilon: dnaQ reductase: reductase: FabZ: fabZ carboxylase E4664_RS16405 glmU β-D-fructofuranose deaminase/5-amino-6-(5-phosphoribosylamino) methyltransferase: E4664_RS12720a cis,cis- E4664_RS12720a (6Z)-3- E1 component: map -methyltransferase reductase E4664_RS13700 E4664_RS01085 E4664_RS01185 an N-terminal L- RlmD: rlmD [+ 17 isozymes] [+ 2 isozymes] E4664_RS14180 subunit F: ahpF E4664_RS14180 biotin D-glucopyranose UDP-N-acetyl- 1-phosphate uracil reductase RibD: ribD acyl-carrier protein delta11,23-3- acyl-carrier protein oxooctadec- met 1939 a (2E)-octadec- acetyl-CoA 1-phosphofructokinase: 5-amino-6-(5-phospho- a 5-carboxymethylaminomethyl- alanyl-[protein] a 5-methyluracil (2E,11Z)-hexadec- a nucleoside 5'- carboxylase 6-phosphate α-D-glucosamine 34 Leu oxo-C42:2-[acp] 6-enoyl-[acp] glutaryl-CoA NADH CO an oleoyl-[acp] an alcohol 2-enoyl-[acp] carboxylase pfkB D-ribitylamino)uracil 2'-O-methyluridine in tRNA 2 in 23S rRNA 2,11-dienoyl-CoA monophosphate an octanoyl-[acp] subunit: accC β-D-fructose 1,6- enoyl-ACP carboxyltransferase pyruvate bisphosphate beta-ketoacyl- reductase: subunit beta: superpathway of aromatic amino acid biosynthesis Amino Acid Biosynthesis an N-terminal- 1-oleoyl-sn 3S-(4- 34 ACP synthase II: E4664_RS14180 E4664_RS00305 superpathway of L- quinoxaline-2- MoO - L-arabinitol an adenosine L-alanine L-histidine biosynthesis L-lysine biosynthesis I L-glutamine L-arginine biosynthesis II (acetyl cycle) a cis,cis-delta7,19- a (7Z)-hexadec- 2 palmitoyl-CoA aryl-carrier protein a malonyl-[acp] a malonyl-[acp] L-methionyl-L- -glycerol 3- hydroxyphenyl) Arg2 E4664_RS12720 a [carboxyl-carrier isoleucine biosynthesis I dimethyl sulfide Inorganic Nutrient Metabolism dGTP carboxyl adenylate C38:2-[acp] 7-enoyl-[acp] molybdopterin ATP in [tRNA ] a stearoyl-[acp] 6 D-erythrose biosynthesis III biosynthesis I selenate reduction assimilatory valyl-[protein] NAD(P)- acyl-CoA phosphate -3-hydroxy- tRNA protein dimer]-N - degradation deoxyguanosinetriphosphate acyl carrier beta-ketoacyl- beta-ketoacyl- cofactor type I methionyl 1-acyl-sn-glycerol- a 3-oxodecanoyl- 4-phosphate N-acetylglutamyl- sulfate reduction III molybdenum cofactor dependent alcohol dehydrogenase: propanoyl-CoA adenosine(34) carboxybiotinyl-L-lysine oxaloacetate PRPP asp C1 Compound Utilization and Assimilation II (oxidation) protein: acpP ACP synthase II: ACP synthase II: aminopeptidase: 3-phosphate enol-CoA [acp] phosphate triphosphohydrolase: guanylyltransferase: dehydrogenase: E4664_RS07800 3-deoxy-7- cys aspartate/ glu bifunctional selenate a quinoxaline-2- E4664_RS12720 E4664_RS12720 map acyltransferase: deaminase aspartate kinase: dimethyl sulfide sulfate E4664_RS01870 a cis,cis- a (9Z)-3-oxo- adenylyl E4664_RS05760 E4664_RS17120 hydratase: phosphoheptulonate cysteine ATP glutamine glutamate N- formaldehyde oxidation sulfate AMP carboxyl-[aryl- an N-terminal [+ 17 isozymes] TadA: tadA tyrosine/aromatic E4664_RS10945 formaldehyde oxidation sulfate 2'-deoxyguanosine triphosphate acyl-carrier protein delta9,21-3- acyl-carrier protein octadec-9- molybdenum met (2E)- E4664_RS19470 E4664_RS01890 an inosine 34 synthase: desulfurase: phosphoribosyltransferase synthetase: acetyltransferase/ II (glutathione-dependent) adenylyltransferase: carrier protein] L-valyl-[protein] L-arabinopyranose dioleoyl (E)-4- aminotransferase: N-acetyl- VII (THF pathway) adenylyltransferase: oxo-C40:2-[acp] enoyl-[acp] cofactor hexadecenoyl-CoA in [tRNA Arg2 ] stearate E4664_RS09185 regulatory subunit: L-aspartyl-4-phosphate E4664_RS04590 cysN cysD phosphatidate coumaroyl-CoA a (3R)-3- E4664_RS06295 E4664_RS16370 amino-acid gamma-glutamyl- adenosine 5'- cysN cysD ala E4664_RS10610 gln acetyltransferase formaldehyde dimethyl sulfoxide hydroxydecanoyl- long-chain fatty 3-deoxy-7- asp phosphate formaldehyde phosphoselenate APS ATP aspartate- ArgJ: argJ [acp] phosphoheptulonate 2605 acid--CoA ligase: phosphoribosyltransferase: reductase: 3-(4- uridine 2-keto-D- a nucleoside a supercoiled 3-hydroxyacyl- synthase: semialdehyde amino-acid N- phosphoadenylyl- urea cycle (2E)-hexadecenoate a peptidoglycan a cis,cis-delta5,17- a (3Z)-dec- palmitoleoyl-CoA β E4664_RS06740 aspartate kinase: E4664_RS13575 acetylglutamate E4664_RS06270 S-(hydroxymethyl) a malonyl-[acp] a malonyl-[acp] hydroxyphenyl) in 23S rRNA gluconate -alanine diphosphate duplex DNA ACP E4664_RS07675 dehydrogenase: acetyltransferase: a 5,10- sulfate reductase: acyl-CoA synthetase: lysozyme: C36:2-[acp] 3-enoyl-[acp] acyl-CoA [+ 3 isozymes] E4664_RS10945 kinase: argB glutathione beta-ketoacyl- beta-ketoacyl- -3-oxo- 23S rRNA 2,5- 4-aminobutyrate- nucleoside- replicative dehydratase 3-deoxy-D-arabino- 1-(5-phospho- asd E4664_RS16620 N-acetyl-L- methylenetetrahydrofolate E4664_RS00785 E4664_RS13800 E4664_RS15840 dehydrogenase: N-acetyl-L- dimethyl sulfone selenite arg ACP synthase II: ACP synthase II: propanoyl-CoAacetyl-CoA C- pseudouridine(2605) didehydrogluconate -2-oxoglutarate diphosphate DNA FabZ: fabZ stearoyl-CoA heptulosonate β-D-ribosyl)-ATP glu glutamate 5- S-(hydroxymethyl) [+ 2 isozymes] E4664_RS07800 L-aspartyl- L-aspartate 4- glutamate bifunctional sulfite [+ 3 isozymes] E4664_RS12720a cis,cis- E4664_RS12720a (5Z)-3- acyltransferase synthase RluB: rluB reductase DkgB: dkgB transaminase: kinase: helicase: 7-phosphate semialdehyde glutathione dimethyl sulfone a N-acetylmuramoyl- a (2E)-dec- 4-phosphate semialdehyde methylenetetrahydrofolate N-acetyl-D- FadA: fadA a pseudouridine 2605 2,5-didehydro- [+ 17 isozymes] E4664_RS14260 dnaB dehydrogenase/ monooxygenase ammonium AMP diphosphate (2E)-hexadecenoyl-CoA pentapeptide- acyl-carrier protein delta7,19-3- acyl-carrier protein oxododec- 4-hydroxybenzoyl- (2E,9Z)- gabT a single 2-enoyl-[acp] 3-dehydroquinate dehydrogenase/ argininosuccinate glucosamine acetyl-CoA in 23S rRNA D-gluconate a nucleoside aspartate- 4-hydroxy- class III alcohol SfnG: sfnG diphosphoundecaprenol oxo-C38:2-[acp] 5-enoyl-[acp] CoA hexadecenoyl-CoA 3-oxopropanoate stranded DNA fatty acid elongation -- saturated synthase: aroB β methenyltetrahydrofolate lyase: argH carbamoyl- triphosphate enoyl-ACP semialdehyde 1-(5-phospho- - tetrahydrodipicolinate superpathway of branched chain amino acid biosynthesis dehydrogenase: bifunctional cyclohydrolase FolD: folD selenodiglutathione phosphate reductase: dehydrogenase: D-ribosyl)-AMP synthase: E4664_RS14050 methanesulfinate 3-dehydroquinate glutamate N- L-cysteine a 5,10- hydrogen sulfide synthase E4664_RS14180 asd E4664_RS17195 L-arginino- UDP-N-acetyl- an N-terminal- an acetoacetyl-[acp] (2S,4S)-4- pyruvate gln acetyltransferase/ biosynthesis I S-(hydroxymethyl) methenyltetrahydrofolate L-ornithine large α-linolenate a malonyl-[acp] a cis,cis-delta3,15- a (7Z)-hexacos- cis-vaccenoyl-CoA (S)-dihydroorotate (3S)-3-hydroxy- type II 3- thr succinate a malonyl-[acp] a malonyl-[acp] a malonyl-[acp] α-D-glucosamine L-methionyl- uroporphyrinogen-III an aliphatic amine L-aspartate 4- hydroxy-2,3,4,5- amino-acid glutathione subunit: carB methyl ester C34:2-[acp] 7-enoyl-[acp] L-aspartate a decanoyl-[acp] dehydroquinate acetolactate bifunctional acyl-CoA synthetase: UDP-N- glycyl-[protein] acyl-CoA primary- semialdehyde 1-(5-phospho-β-D-ribosyl)- tetrahydrodipicolinate acetyltransferase dehydrogenase/ beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- type I methionyl uroporphyrinogen threo-3-hydroxy- synthase: ilvN threonine carbamoyl- ser methylenetetrahydrofolate glutathioselenol carbamoyl E4664_RS13800 acetylglucosamine dehydrogenase: dihydroorotase: amine dehydratase: aroQ 5-[(5-phosphoribosylamino) 4-hydroxy- ArgJ: argJ N-acetyl-L- class III alcohol ACP synthase II: ACP synthase II: ACP synthase II: aminopeptidase: decarboxylase: L-aspartate beta-ketoacyl- homoserine E4664_RS14140 ammonia-lyase: phosphate serine dehydrogenase/ methanesulfonate phosphate [+ 3 isozymes] 2-epimerase E4664_RS07800 pyrC oxidase: type I 3- methylideneamino]imidazole- tetrahydrodipicolinate ornithine dehydrogenase: E4664_RS12720 E4664_RS12720a cis,cis- E4664_RS12720a (9Z)-3- map E4664_RS02695 ammonia-lyase: ACP synthase II: dehydrogenase: E4664_RS00700 synthase acetyltransferase: methenyltetrahydrofolate a 3-oxoglutaryl- (hydrolyzing): neuC an N-terminal [+ 17 isozymes] tynA E4664_RS12720 dehydroquinate 4-carboxamide reductase: dapB (S)-2-acetolactate large E4664_RS09175 E4664_RS07070 argininosuccinate α acyl-carrier protein acyl-carrier protein delta5,17-3- acyl-carrier protein oxooctacos- N-acetyl-α-D- met (2E,11Z)- N-carbamoyl- E4664_RS02585 a 3-oxoacyl-[acp] E4664_RS15565 threonine cyclohydrolase FolD: folD 2-aminoethylphosphonate AMP diphosphate -linolenoyl-CoA [acp] methyl ester UDP glycyl-[protein] coproporphyrinogen III an aldehyde a 3- dehydratase: 1-(5-phosphoribosyl) (S)-2,3,4,5- subunit: carB synthase: argG oxo-C36:2-[acp] 9-enoyl-[acp] mannosamine octadecenoyl-CoA L-aspartate oxaloacetate ammonia- serine O- S-formylglutathione a 10- degradation I oxododecanoyl- E4664_RS06420 L-homoserine -5-((5- tetrahydrodipicolinate ketol-acid acetyltransferase: hydrogen selenide L-citrulline phosphoribosylamino) reductoisomerase: lyase, carbamoyl L-ornithine formyltetrahydrofolate sulfite (2-aminoethyl) [acp] 2,3,4,5- cysE 3-dehydroshikimate homoserine methylideneamino) ilvC biosynthetic: phosphate L-proline S-formylglutathione phosphonate tetrahydropyridine- O-acetyl-L-serine formyltetrahydrofolate 2-aminoethylphosphonate- (7Z)- (5Z)- kinase: imidazole-4- (2R)-2,3- ilvA biosynthesis I hydrolase: fghA phytenate a glutaryl-[acp] a cis-delta19- a (5Z)-tetracos- a peptide with a uroporphyrinogen-I a primary amine 2,6-dicarboxylate N- deformylase: purU -pyruvate a malonyl-[acp] a malonyl-[acp] a malonyl-[acp] ATP a ribonucleic acid tetradecenoyl-CoA dodecenoyl-CoA asp E4664_RS18180 carboxamide isomerase: dihydroxy-3- (2Z)-2-aminobut- (from L-glutamate) S-formylglutathione acyl-CoA synthetase: methyl ester C38:1-[acp] 5-enoyl-[acp] leader sequence acyl-CoA acyl-CoA primary- a (3R)-3- succinyltransferase: cysteine synthase transaminase: phnW beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- signal uroporphyrinogen aspartate/ beta-ketoacyl- E4664_RS18215 methylbutanoate 2-enoate hydrolase: fghA formate phosphate acquisition E4664_RS13800 polynucleotide dehydrogenase: dehydrogenase: amine hydroxydodecanoyl- O-phospho- dapD glu CysM: cysM phosphonoacetaldehyde ACP synthase II: ACP synthase II: ACP synthase II: peptidase decarboxylase: tyrosine/aromatic ACP synthase II: taurine [+ 3 isozymes] adenylyltransferase E4664_RS07800 E4664_RS07800 oxidase: [acp] shikimate L-homoserine phosphoribulosylformimino- glutamate cysteine formate E4664_RS12720 E4664_RS12720 E4664_RS12720a (7Z)-3- I: lepB E4664_RS02695 aminotransferase: E4664_RS12720 a (3R)-3- N-succinyl-2-amino- degradation IV a phosphate a 3-oxopimeloyl- a cis-delta21-3- PcnB: pcnB tynA 3-hydroxyacyl- a 2,3,4-saturated AICAR-phosphate synthase A: cysK phosphonoacetaldehyde [+ 17 isozymes] [+ 17 isozymes] E4664_RS16370 hydroxyacyl-[acyl- shikimate threonine 6-ketopimelate 5-kinase: diphosphate AMP phytenoyl-CoA acyl-carrier protein acyl-carrier protein acyl-carrier protein oxohexacos- a ribonucleic acid a leader sequence a peptide coproporphyrinogen I (2E,7Z)- (2E,5Z)- ACP fatty acyl-[acp] 3-methyl-2- hydrolase: E4664_RS09505 monoester [acp] methyl ester oxo-C40:1-[acp] an aldehyde 3-hydroxyacyl-carrier protein] kinase synthase: E4664_RS10765 taurine acid phosphatase: 7-enoyl-[acp] tetradecenoyl-CoA dodecenoyl-CoA oxaloacetate dehydratase succinyldiaminopimelate oxobutanoate 2-iminobutanoate cys ACP AroK: aroK E4664_RS15570 imidazole γ [+ 2 isozymes] taurine acetaldehyde E4664_RS06965 FabZ: fabZ transaminase: dapC -L-glutamyl dehydratase glycerol 5-phosphate dioxygenase: phosphate thr phosphate N-succinyl-L,L-2,6- 2-isopropylmalate branched-chain (S)-3- an N ω -(1- a (2E)-dodec- FabZ: fabZ shikimate 3-phosphate tauD a very-long- a cis-delta17- a (3Z)-docos- (2E,6Z,9Z,12Z,15Z,18Z) an N-terminal-L-methionyl- a double synthase: diaminopimelate synthase: leuA amino acid glutamate-5- 2-aminoacetaldehyde DL-allothreonine a malonyl-[acp] a malonyl-[acp] 4-hydroxybenzoate hydroxyhexadecanoyl- malonate hydroxy-2- 2-enoyl-[acp] L-citrulline chain fatty acid C36:1-[acp] 3-enoyl-[acp] -tetracosahexaenoyl-CoA L-threonyl-[protein] stranded DNA bifunctional prephenate threonine hisF hisH succinyl- transaminase: 2-oxobutanoate semialdehyde long-chain-acyl- type I methionyl CoA biotin-independent oxopropyl) DNA enoyl-ACP L-glutamate serine beta-ketoacyl- beta-ketoacyl- enol-CoA 4-hydroxybenzoate enol-CoA dehydrogenase/3- ammonia-lyase: diaminopimelate (2S)-2- E4664_RS00125 dehydrogenase: acetyl-CoA CoA synthetase: aminopeptidase: malonate -[protein]- gyrase reductase: argininosuccinate biosynthesis III hydroxymethyltransferase: ACP synthase II: ACP synthase II: hydratase: 3-monooxygenase: hydratase: phosphoshikimate 1- E4664_RS00700 D-erythro-1- desuccinylase: isopropylmalate acetolactate E4664_RS14300 E4664_RS14765 map decarboxylase: mdcE L-arginineprotein subunit E4664_RS14180 a trans-2- AICAR synthase: argG E4664_RS03550 E4664_RS12720 E4664_RS12720a (5Z)-3- E4664_RS01890 pobA E4664_RS01890 a 2,3,4-saturated enoyl-ACP carboxyvinyltransferase: threonine (imidazol-4- dapE 3-isopropylmalate synthase: ilvN L-glutamate-5- a cis-delta19-3- an N-terminal L- E4664_RS09095 deglycase A: gyrA enoyl-[acyl- 2-oxoglutarate a very-long-chain gly acetaldehyde acyl-carrier protein acyl-carrier protein oxotetracos- (3S,6Z,9Z,12Z,15Z,18Z)-3- met (2E)- fatty acyl-[acp] reductase: E4664_RS03715 ammonia- yl)-glycerol dehydratase: val E4664_RS14140 L-arginino- semialdehyde AMP diphosphate oxo-C38:1-[acp] threonyl-[protein] protocatechuate acetate aHchA: [protein]- hchA a negatively a dodecanoyl-[acp] carrier protein] NADP-specific fatty acyl-CoA 5-enoyl-[acp] hydroxytetracosapentaenoyl-CoA hexadecenoyl-CoA (R)-lactate E4664_RS14180 lyase, 3-phosphate L,L-diaminopimelate leuD leuC (S)-2-aceto-2- succinate L-arginine supercoiled DNA 5-enolpyruvoyl- glutamate biosynthetic: imidazoleglycerol- hydroxybutanoate argininosuccinate shikimate 3-phosphate 2-isopropylmaleate dehydrogenase: beta-ketoacyl- ilvA phosphate diaminopimelate ketol-acid lyase: argH enoyl-ACP chorismate E4664_RS11845 a double-stranded 6-O-cis-keto- ACP synthase II: dehydratase epimerase: dapF 3-isopropylmalate reductoisomerase: (S)-1-pyrroline- phosphatidylglycerolphosphate an acyl-[acyl- a cis-delta15- a (5Z)-tetradec- a [ThiI sulfur-carrier L-selenocystathionine oxaloacetate L-cysteate reductase: synthase: (2Z)-2-aminobut- glu Nucleoside and Nucleotide Degradation a malonyl-[acp] a malonyl-[acp] a malonyl-[acp] cys oligonucleotide mycolyl-trehalose E4664_RS12720 HisB: hisB dehydratase: ilvC arg 5-carboxylate (1-oleoyl, 2-palmitoyl) carrier protein] C34:1-[acp] 5-enoyl-[acp] protein]-L-cysteine cystathionine GTP E4664_RS14180 aroC 2-enoate 3-(imidazol-4- beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- cysteine phosphoenolpyruvate aspartate/ 6-phosphate laurate meso-diaminopimelate leuD leuC (R)-2,3-dihydroxy- beta-lyase: oligoribonuclease: trehalose- yl)-2-oxopropyl pyrroline-5- purine nucleotides degradation II (aerobic) phosphatidylglycerophosphatase ACP synthase II: ACP synthase II: ACP synthase II: desulfurase: carboxykinase (GTP) tyrosine/aromatic (2R,3S)-3- 3-methylpentanoate carboxylate E4664_RS19010 E4664_RS14190 guanylate cyclase: phosphatase: a 3-oxotetradecanoyl- long-chain fatty chorismate phosphate pyrimidine deoxyribonucleosides degradation A: E4664_RS17385 E4664_RS12720 E4664_RS12720 E4664_RS12720a (7Z)-3-oxo- a [ThiI sulfur- E4664_RS09185 : E4664_RS01380 aminotransferase: diaminopimelate isopropylmalate reductase: seleno-L- E4664_RS07870 otsB [acp] acid--CoA ligase: histidinol- 1-oleoyl-2-palmitoyl- acyl-carrier protein a 3-oxoacyl-[acp] acyl-carrier protein a cis-delta17-3- acyl-carrier protein hexadec-7- carrier protein]-S- ala pyruvate phosphoenol a nucleoside 5'- E4664_RS16370 decarboxylase: 3-isopropylmalate E4664_RS10305 2'-deoxycytidine oxo-C36:1-[acp] homocysteine trehalose-cis-keto- E4664_RS06740 chorismate 2-iminobutanoate phosphate AMP phosphatidylglycerol enoyl-[acp] sulfanyl-L-cysteine pyruvate monophosphate 3-sulfopyruvate cyclic-GMP cis-vaccenate E4664_RS20290 dehydrogenase: mono-mycolate [+ 3 isozymes] mutase: transaminase: superpathway pyrroline-5- biosynthesis diaminopimelate leuB (S)-3-methyl-2- E4664_RS05305 E4664_RS13565 of L-threonine carboxylate a (3R)-3- lauroyl-CoA decarboxylase: lysA oxopentanoate bifunctional anthranilate L-histidinol (2S)-2-isopropyl- biosynthesis reductase: (25S)-3- 3-[(4'- a [protein]- hydroxytetradecanoyl- branched-chain metallophosphatase/ an N-modified an aromatic a palmitoleoyl-[acp] phosphate 3-oxosuccinate E4664_RS13690 2'-deoxyuridine thymidine palmitoyl-CoA a ferrocytochrome b a cis,cis-delta19- a cis-delta13- a (3Z)-dodec- oxocholest- coenzyme A 2-hydroxyisobutyramide methylsulfanyl) an aldehyde L-tyrosine 2-oxobutanoate lys amino acid oxaloacetate 5'-nucleotidase: 5 a malonyl-[acp] a malonyl-[acp] a malonyl-[acp] [acp] beta-ketoacyl- anthranilate prephenate 37-C56:2-[acp] C32:1-[acp] 3-enoyl-[acp] aminoacyl-[tRNA] butyl]malate amino acid phosphate 3-hydroxyacyl- transaminase: aspartate/ E4664_RS07150 pyrimidine/purine acyl-CoA desaturase: beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- aminoacyl-tRNA 4-en-26-oate acyl-CoA NAD(P)- aspartate/ ACP synthase II: phosphoribosyltransferase: trpD pro pyrimidine/purine amidase: 3-isopropylmalate protein tyrosine ACP acetolactate E4664_RS00125 tyrosine/aromatic 5'-nucleotidase SurE: nucleoside E4664_RS16570 ACP synthase II: ACP synthase II: ACP synthase II: hydrolase: synthetase: dependent alcohol tyrosine/aromatic an (11Z)-3-E4664_RS12720 N-(5-phosphoribosyl) prephenate bifunctional prephenate synthase: ilvN aminotransferase: IMP nucleoside E4664_RS06510 dehydrogenase: dehydrogenase: phosphatase: dehydratase 4-methyl-2- E4664_RS02475 phosphorylase: [+ 3 isozymes] E4664_RS12720a cis,cis- E4664_RS12720 E4664_RS12720a (5Z)-3-oxo- E4664_RS12875 (25S)-3-E4664_RS13800 aminotransferase: phosphatidylglycerol oxooctadec- -anthranilate dehydratase: dehydrogenase/3- E4664_RS14140 E4664_RS16370 phosphorylase: a cis-delta15-3- an N-modified an uncharged leuB E4664_RS17120 E4664_RS00320 FabZ: fabZ histidinol oxopentanoate ile GMP E4664_RS15150 a ferricytochrome b palmitoleoyl-CoA acyl-carrier protein delta21,39-3- acyl-carrier protein acyl-carrier protein tetradec-5- oxocholest-4- 2-hydroxy-2- 7-(methylsulfanyl) E4664_RS16370 a [protein]- biosynthesis I (plastidic) 11-enoyl-[acp] pheA phosphoshikimate 1- E4664_RS15150 5 oxo-C34:1-[acp] amino acid tRNA an aromatic phosphoribosylanthranilate (S)-2-aceto-2- superpathway of L-serine asp adenosine oxo-C58:2-[acp] enoyl-[acp] en-26-oyl-CoA methylpropanoate -2-oxoheptanoate an alcohol L-tyrosine a (2E)-tetradec- carboxyvinyltransferase: histidinol branched-chain IMP dehydrogenase: thymine 2-oxo-acid DHAP isomerase: E4664_RS00270 hydroxybutanoate and glycine biosynthesis I bifunctional 2-enoyl-[acp] 3-phenyl-2- E4664_RS03715 dehydrogenase: amino acid L-asparagine biosynthesis guaB NAD(P)H- 1-(2- ketol-acid transaminase: aspartate kinase: adenosine deaminase: metallophosphatase/ enoyl-ACP a (3R,11Z)-3- oxopropanoate reductoisomerase: hisD 3-phospho-D-glycerate III (tRNA-dependent) E4664_RS10970 5'-nucleotidase: dependent carboxyphenylamino) E4664_RS00125 E4664_RS10945 a cis,cis- (2E,6Z,9Z,12Z,15Z,18Z,21Z) S-(5- 3-[(7'-methylsulfanyl) 3-[(6'- (11Z)-(S)-3- a negatively reductase: hydroxyoctadec- aspartate/ 3-(4-hydroxyphenyl) ilvC phosphoglycerate E4664_RS07150 XMP a cis-delta11- glycerol-3- -1-deoxy-D-ribulose histidinal adenosine deaminase: an N-formyl-L-methionylaminoacyl-tRNA delta17,35- a malonyl-[acp] a malonyl-[acp] an oleoyl-[acp] a malonyl-[acp] -tetracosaheptaenoyl-CoA hydroxypentan- heptyl]malate methylsulfanyl) hydroxyhexadec- supercoiled DNA D-serine E4664_RS14180 11-enoyl-[acp] tyrosine/aromatic pyruvate dehydrogenase: serA asp α C30:1-[acp] phosphate 3-hydroxyacyl- 5-phosphate (R)-2,3-dihydroxy- leu L-aspartyl- E4664_RS13430 5'-nucleotidase SurE: uracil 2-deoxy- - peptide deformylase: def C54:2-[acp] beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- enol-CoA 3-yl)-L-cysteinecystathionine 3-isopropylmalate hexyl]malate 11-enoyl-CoA type I DNA indole-3- aminotransferase: aspartate/ 3-methylpentanoate histidinol 3-phosphooxypyruvate 4-phosphate E4664_RS02475 bifunctional D-ribose 1- 3-isopropylmalate enol-CoA topoisomerase: D-serine a myristoyl-[acp] dehydrogenase: ACP peptide deformylase: ACP synthase II: ACP synthase II: ACP synthase II: hydratase: beta-lyase: dehydrogenase: glycerol E4664_RS16370 tyrosine/aromatic dehydrogenase: inosine metallophosphatase/ phosphate dehydrogenase: hydratase: topA ammonia-lyase: E4664_RS03820 dehydratase L-methionine biosynthesis III aspartate- E4664_RS15950 E4664_RS12720a cis,cis- E4664_RS12720 E4664_RS12720an (11Z)-3- E4664_RS01890 E4664_RS19010 leuB sn-glycerol phosphate aminotransferase: hisD guanosine 5'-nucleotidase: a cis-delta13-3- 3-sulfanylpentan- leuB E4664_RS01890 [+ 2 isozymes] E4664_RS12130 beta-ketoacyl- FabZ: fabZ phe semialdehyde formate a L-methionylaminoacyl-tRNA acyl-carrier protein delta19,37-3- acyl-carrier protein acyl-carrier protein oxo-icos-11- (3S,6Z,9Z,12Z,15Z,18Z,21Z)-3- pyruvate 10-(methylsulfanyl) 9-(methylsulfanyl) (2E,11Z)-hexadec- 3-phosphate a (2E,11Z)- synthase E4664_RS16370 pyrimidine/purine E4664_RS07150 oxo-C32:1-[acp] 1-ol a relaxed DNA pyruvate ACP synthase II: dehydrogenase: an L-aspartyl- oxo-C56:2-[acp] enoyl-[acp] hydroxytetracosahexaenoyl-CoA -2-oxodecanoate -2-oxononanoate 2,11-dienoyl-CoA TrpC: trpC (S)-3-methyl-2- his L-homoserine nucleoside 5'-nucleotidase SurE: E4664_RS12720 glycerol-3- octadeca-2,11- Asn pyrimidine/purine tyr oxopentanoate O-phospho-L-serine homoserine O- asd [tRNA ] phosphate 1-O- dienoyl-[acp] (1S,2R)-1-C-(indol-3- gln phosphorylase: nucleoside E4664_RS02475 a 3-oxohexadecanoyl- acetyltransferase: acyltransferase enoyl-ACP yl)glycerol 3-phosphate branched-chain L-aspartate 4- Asp-tRNA(Asn) E4664_RS15150 phosphorylase: a cis,cis- a peptide with (E)-1-(L-cystein-S- S-(1- 3-[(5'- 6-O-α-mycolyl- [acp] phosphoserine E4664_RS14385 a cis-delta9- PlsB: plsB reductase: amino acid O-acetyl-L- semialdehyde /Glu-tRNA(Gln) glutaminase: E4664_RS15150 xanthosine an acetyl-[acp] a malonyl-[acp] delta15,33- a malonyl-[acp] a malonyl-[acp] an N-terminal yl)-N-hydroxy-2-(4- hydroxyhexan- 4-guanidinobutyramide methylsulfanyl) Ins(1)P myristoyl-CoA trehalose 6- tryptophan phosphatase SerB: serB hydrogen sulfide purine ribonucleosides degradation a 1-acyl-sn E4664_RS14180 transaminase: homoserine amidotransferase: hypoxanthine C28:1-[acp] 3-yl)-L-cysteine pentyl]malate acyl-CoA phosphate synthase: trpB homoserine E4664_RS12190 beta-ketoacyl- C52:2-[acp] beta-ketoacyl- beta-ketoacyl- Xaa-L-prolineleucyl hydroxyphenyl)ethan-1-iminecystathionine cystathionine inositol -glycerol 3- a cis- E4664_RS00125 bifunctional phosphoserine dehydrogenase: gatB gatA gatC guanine amidase: 3-isopropylmalate dehydrogenase: trehalose- E4664_RS00300 S-adenosyl-L-methionine cycle II a 4-phosphooxy- [+ 5 isozymes] ACP synthase II: ACP synthase II: ACP synthase II: aminopeptidase: beta-lyase: beta-lyase: monophosphatase: phosphate vaccenoyl-[acp] phosphatase/homoserine E4664_RS15565 pyrimidine/purine E4664_RS06510 dehydrogenase: E4664_RS07800 phosphatase: a (3R)-3- ile L-aspartyl- adenosine E4664_RS12720 E4664_RS12720a cis,cis- E4664_RS12720 a peptide with E4664_RS15615 (Z)-N-hydroxy-2-E4664_RS19010 E4664_RS19010 E4664_RS18895 1-acyl-sn-glycerol- [+ 2 isozymes] S-adenosyl-L-methionine cycle I phosphotransferase ammonium xanthine nucleoside a cis-delta11-3- a proteinogenic 3-sulfanylhexan- leuB [+ 17 isozymes] otsB hydroxyhexadecanoyl- Asn an acetoacetyl-[acp] acyl-carrier protein acyl-carrier protein delta17,35-3- acyl-carrier protein an N-terminal pyruvate (4-hydroxyphenyl) pyruvate α α 3-phosphate ThrH: thrH L-homoserine [tRNA ] dehydrogenase: phosphorylase: oxo-C30:1-[acp] amino acid 1-ol 4-guanidinobutanoate 8-(methylsulfanyl) myo-inositol (2E)-tetradec- , '-trehalose [acp] met L-homocysteine guanine oxo-C54:2-[acp] L-proline acetimidothioate α acyltransferase: ser indole methionine xdhA xdhB E4664_RS15150 adenosine deaminase: -2-oxooctanoate 2-enoyl-CoA 6- -mycolate 3-hydroxyacyl- ser Asp-tRNA(Asn) deaminase: guaD E4664_RS19470 adenosyltransferase: SAM methionine methionine homoserine E4664_RS10970 ACP a 1,2-diacyl- cis-vaccenate kinase: /Glu-tRNA(Gln) tryptophan methionine synthase: E4664_RS08575 synthase: synthase: adenosine deaminase: 3-[(3'- dehydratase sn-glycerol serine E4664_RS18180 amidotransferase: xanthine an L-methionyl- a cis,cis- (E)-1-(L-cystein-S- synthase E4664_RS13330 E4664_RS13330 metH E4664_RS13430 a 10- O-succinyl-L- (S)-2- H O diphosphate methylsulfanyl) Ins(2)P propan-1-ol FabZ: fabZ 3-phosphate methionine hydroxymethyltransferase: gatB gatA gatC Met delta13,31- a malonyl-[acp] yl)-N-hydroxy-2-(1H- L-djenkolate glu 2 ser subunit methionine synthase: metH O-phospho- xanthine formyltetrahydrofolate [initiator tRNA ] homoserine aminobutanoate phosphatidate adenosyltransferase: E4664_RS03550 methionine methionine methionyl-tRNA C50:2-[acp] beta-ketoacyl- O-succinylhomoserine indol-3-yl)ethan-1-iminecystathionine cystathionine glutamate-- inorganic propyl]malate NAD(P)- a (2E)-hexadec- beta: trpB L-homoserine dehydrogenase: xanthosine adenosine inosine guanosine 3-isopropylmalate inositol L-serine 2-enoyl-[acp] cytidylyltransferase: alanine E4664_RS08575 synthase: synthase: an L-asparaginyl- glycine biosynthesis II formyltransferase: ACP synthase II: sulfhydrylase: beta-lyase: beta-lyase: cysteine ligase: diphosphatase: monophosphatase: dependent alcohol tryptophan gly metH E4664_RS13330 threonine xdhA xdhB dehydrogenase: dehydrogenase: ammonia-lyase: E4664_RS05925 L-homocysteine SAM racemization met SAH [tRNA Asn ] an N-formyl- E4664_RS17015 E4664_RS12720a cis,cis- E4664_RS07545 E4664_RS19010 E4664_RS19010 E4664_RS17505 E4664_RS15785 E4664_RS18895 enoyl-ACP synthase (E)-2-(1H-indol-3-yl)- γ-L-glutamyl-(S)- leuB E4664_RS09695 a CDP- synthase: L-methionyl- a tetrahydrofolate acyl-carrier protein delta15,33-3- succinate L-homocysteine pyruvate pyruvate S-(sulfanylmethyl) phosphate H + E4664_RS17120 reductase: subunit met a [glycine-cleavage complex urate pyrimidine/purine pyrimidine/purine pyrimidine/purine pyrimidine/purine 1-thioacetohydroximate 2-aminobutanoate 6-(methylsulfanyl) myo-inositol E4664_RS15570 gly met -L-cysteine 1-propanal pyruvate diacylglycerol H protein] N 6 -lipoyl-L-lysine [initiator tRNA ] oxo-C52:2-[acp] -2-oxohexanoate E4664_RS14180 (Kdo) -lipid A beta: trpB ala glycine cleavage system nucleoside nucleoside nucleoside nucleoside CDP-diacylglycerol-- 2 alanine methionine synthase: biosynthesis I (E. coli) thr protein GcvH: gcvH phosphorylase: phosphorylase: phosphorylase: phosphorylase: a palmitoyl-[acp] glycerol-3-phosphate 3- trp racemase: alr E4664_RS13330 a [glycine-cleavage complex H protein] E4664_RS15150 E4664_RS15150 E4664_RS15150 E4664_RS15150 α α adenosylhomocysteinase: 6 a cis,cis- (E)-1-(L-cystein-S-yl)-N- (E)-2- phosphatidyltransferase: -Kdo-(2->4)- -Kdo- methionine synthase: metH N -aminomethyldihydrolipoyl-L-lysine a 2'-deoxyribonucleoside + orotidine 5'- [+ 2 isozymes] L-homocysteine S-ribosyl-L-homocysteine ferulate [DNA] ω protoporphyrinogen IX FMN NAD(P)H H an S-alkyl- methylcrotonoyl- a folate butan-1-ol pgsA (2->6)-lipid IV (E. coli) E4664_RS02865 D-ala UTP and CTP dephosphorylation I delta11,29- a malonyl-[acp] 5'-triphosphate hydroxy- -(methylsulfanyl) phosphate lauroylA acyltransferase: α flavin reductase: L-cysteine CoA 1-(3-sn- SAH -D-ribose-1-phosphate feruloyl-CoA synthase: C48:2-[acp] beta-ketoacyl- DNA polymerase III pentan-1-iminecystathionine cystathionine dihydrofolate NAD(P)- orotidine-5'- E4664_RS10135 UTP protoporphyrinogen E4664_RS13325 enol-CoA phosphatidyl) E4664_RS11115 ACP synthase II: subunit alpha: dnaE beta-lyase: beta-lyase: reductase: dependent alcohol phosphate lipid A biosynthesis oxidase HemJ: hemJ [+ 3 isozymes] hydratase: dehydrogenase: palmitate -sn-glycerol E4664_RS12720a cis,cis- [+ 10 isozymes] E4664_RS19010 E4664_RS19010 E4664_RS01890 E4664_RS14465 decarboxylase: lauroyl acyltransferase: CTP synthase: diphosphate AMP trans-feruloyl-CoA (E)-ω-(methylsulfanyl) NAD(P) + FMNH E4664_RS17120 3-phosphate acyl-carrier protein delta13,31-3- [DNA] pyruvate 2 pyruvate an alkyl-thiol pyrF E4664_RS01750 protoporphyrin IX 3-hydroxyisovaleryl- a 7,8-dihydrofolate long-chain fatty α-Kdo-(2->4)-α-Kdo-(2-> E4664_RS06340 pentyl-thiohydroximate butan-1-al UMP phosphatidylglycerophosphatase Nucleoside and Nucleotide Biosynthesis D-ribose 5-phosphate oxo-C50:2-[acp] CoA acid--CoA ligase: A: E4664_RS17385 6)-(lauroyl)-lipid IV (E. coli) UDP A CTP E4664_RS06740 an L-1- superpathway of guanosine [+ 3 isozymes] phosphatidyl- pyrimidine deoxyribonucleotide (E)-1-(L-cystein-S-yl)-N- a 5' triphospho- RNase G nucleotides de novo biosynthesis I superpathway of inosine-5'-phosphate biosynthesis I adenine and adenosine salvage III pyrimidine deoxyribonucleotides de novo biosynthesis I superpathway of pyrimidine guanine and guanosine salvage a sulfurated a cis,cis-delta9,27- orotidine 5'- S-benzyl- reduced riboflavin butan-1-ol (S)-malate α α phosphorylation SAM dethiobiotin a malonyl-[acp] hydroxy-ω-(methylsulfanyl) [mRNA] a tRNA precursor degradation palmitoyl-CoA sn-glycerol -D-Kdo-(2->4)- -D- adenosine nucleotides nucleobases salvage UMP [sulfur carrier] C46:2-[acp] phosphate L-cysteine purine deoxyribonucleosides degradation I beta-ketoacyl- orotate heptan-1-iminecystathionine RNA cystathionine substrate mRNA flavin reductase: NAD(P)- malate Kdo-(2->6)-lipid A (E. coli) de novo biosynthesis I AIR UDP CTP dTMP dCMP CDP biotin synthase: ribonuclease D: uracil bifunctional ACP synthase II: phosphoribosyltransferase: beta-lyase: pyrophosphohydrolase: beta-lyase: ribonuclease G: E4664_RS13325 dependent alcohol dehydrogenase IMP adenine ribonucleoside- uracil guanosine dTMP kinase: (d)CMP kinase: adenosine deaminase: E4664_RS08625 E4664_RS07525 5-(carboxyamino) diphosphate reductase: metallophosphatase/ an unsulfurated E4664_RS12720a cis,cis- pyrE E4664_RS19010 E4664_RS14705 a nucleoside 5'- E4664_RS19010 E4664_RS00770 [+ 4 isozymes] dehydrogenase: (quinone): mqo IMP asp pyrimidine/purine phosphoribosyltransferase: pyrimidine/purine E4664_RS01980 E4664_RS08305 E4664_RS10970 met 5'-deoxyadenosine biotin (E)-ω-(methylsulfanyl) a tRNA E4664_RS17120 IMP imidazole ribonucleotide E4664_RS13295 CDP dTDP dCDP 5'-nucleotidase: 2'-deoxyadenosine [sulfur carrier] acyl-carrier protein delta11,29-3- orotate PRPP pyruvate a 5'-phospho- monophosphate pyruvate benzyl thiol adenylosuccinate nucleoside phosphorylase: E4664_RS13200 nucleoside phosphorylase: adenosine deaminase: heptyl-thiohydroximate an mRNA fragment riboflavin oxaloacetate dehydrogenase: synthase: E4664_RS16780 E4664_RS13305 CMP E4664_RS07150 oxo-C48:2-[acp] [mRNA] butan-1-al synthase: E4664_RS15150 ribonucleoside- UMP E4664_RS15150 nucleoside- nucleoside- E4664_RS13430 guaB adenosine dUDP 5'-nucleotidase SurE: E4664_RS10605 diphosphate reductase: guanine diphosphate diphosphate bifunctional adenylo-succinate N5-CAIR UMP kinase: pyrH E4664_RS02475 nucleoside-diphosphate E4664_RS13295 kinase: kinase: metallophosphatase/ (d)CMP kinase: RNase III mRNA (E)-1-(L-cystein-S-yl)-N- a monocarboxylic XMP adenosine deaminase: kinase: E4664_RS14260 E4664_RS13305 hypoxanthine 5'-nucleotidase: uridine 2'-deoxyinosine 2'-deoxyguanosine a 5-L-glutamyl- a cis,cis-delta7,25- FMNH NADP + glycerol 5-(carboxyamino)imidazole E4664_RS14260 E4664_RS14260 ω 2 phytol acetamide adenylosuccinate E4664_RS10970 E4664_RS08305 phosphoribosyltransferase: hpt E4664_RS07150 an amino acid a malonyl-[acp] processing hydroxy- -(methylsulfanyl) a PII protein UTP S-ethyl-L-cysteine acid amide ribonucleotide mutase: purE dUTP dCDP pyrimidine/purine [peptide] C44:2-[acp] substrate nonan-1-imine flavin reductase: NAD(P)- NAD(P)- lyase: purB adenosine deaminase: UDP xanthine dTTP dCTP gamma- beta-ketoacyl- ribonuclease III: cystathionine [protein-PII] cystathionine superpathway of 5-aminoimidazole 5'-nucleotidase SurE: nucleoside E4664_RS07215 dependent alcohol amidase: dependent alcohol amidase: asp E4664_RS13430 dUTP diphosphatase: nucleoside-diphosphate phosphoribosyltransferase: glutamyltransferase: ggt ACP synthase II: E4664_RS02020 beta-lyase: uridylyltransferase: beta-lyase: CAIR ribonucleotide biosynthesis nucleoside-diphosphate E4664_RS02475 pyrimidine/purine phosphorylase: pyrimidine/purine an α-(5-L- RNase III [+ 3 isozymes] dehydrogenase: E4664_RS06510 dehydrogenase: E4664_RS06510 AMP E4664_RS12610 kinase: E4664_RS14260 E4664_RS19280 E4664_RS15150 E4664_RS12720a cis,cis- E4664_RS19010 glnD E4664_RS19010 kinase: E4664_RS14260 cytidine nucleoside nucleoside a peptide glutamyl)- an mRNA fragment processing (E)-ω-(methylsulfanyl) a uridylylated H + NADPH FMN E4664_RS17120 E4664_RS17120 inosine nucleoside triphosphate dCTP acyl-carrier protein delta9,27-3- pyruvate pyruvate ethanethiol phosphoribosylaminoimidazolesuccinocarboxamide PRPP UTP phosphorylase: phosphorylase: amino acid product mRNA nonyl-thiohydroximate PII protein L-glyceraldehyde a monocarboxylate phytenal acetate GMP pyrophosphohydrolase: GMP E4664_RS15150 E4664_RS15150 oxo-C46:2-[acp] adenylate kinase: synthase: purC pyrimidine/purine mazG amidophosphoribosyltransferase: purF CTP synthase: pyrimidine deoxyribonucleotides E4664_RS11865 nucleoside phosphorylase: 5-phospho-β- E4664_RS06340 dephosphorylation guanylate kinase: dUMP 2-deoxy-α-D-ribose 1-phosphate an (S-diacyl-sn- (E)-1-(L-cystein-S-yl)-N- (5E)-3-oxo- SAICAR E4664_RS15150 D-ribosylamine nucleoside triphosphate an L-1- an N-terminal-L-methionyl- 6-cis, 3-oxo- propane-1,2,3- E4664_RS18555 CMP CTP glyceryl)-L-cysteinyl- isobutanoate an L-arginyl- an N-terminal L- ω dodec-5- xylitol an L-asparaginyl- oxaloacetate xanthine and Arg hydroxy- -(methylsulfanyl) L-cysteinyl-[protein] tridecenoyl-CoA Asn tricarboxylate ADP thymidylate synthase: thyA phosphoribosylamine- pyrophosphohydrolase: phosphatidylethanolamine [tRNA ] glutamyl-[protein] type I methionyl NAD(P)- [tRNA ] adenylosuccinate hypoxanthine phosphorylation xanthosine salvage [apolipoprotein] acetate--CoA hexan-1-iminecystathionine acetyl-CoA C- enoyl-CoAacetyl-CoA C- aminoacyl-tRNA FAD-dependent -glycine ligase: purD mazG apolipoprotein N- arginyltransferase: aminopeptidase: dependent alcohol 2-methylcitrate lyase: purB dCTP dCMP ligase: acs beta-lyase: acyltransferase acyltransferase hydrolase: tricarballylate GDP ribonucleoside- dTMP CMP acyltransferase:an N-acyl-(S -diacyl-lnt E4664_RS12675 map dehydrogenase: synthase: prpC hypoxanthine (d)CMP kinase: a 2-acyl-1-lyso- an N-terminal E4664_RS19010 FadA: fadA FadA: fadA E4664_RS12875 dehydrogenase diphosphate dTMP kinase: GAR xanthosine sn-glyceryl)-L- Arg ω an N-terminal L- 4-cis- E4664_RS17120 AICAR guanine and guanosine salvage II Amino Acid Degradation isobutanoyl-CoA AMP diphosphate L-arginiyl-L- a tRNA (E)- -(methylsulfanyl) acetyl-CoA (3E)-dec-3- Asn TcuA: tcuA reductase: phosphoribosyltransferase: hpt E4664_RS08305 dUTP diphosphatase: phosphatidylethanolamine pyruvate met undecenoyl-CoA acetyl-CoA tRNA asn (2S,3S)-2- E4664_RS01980 CDP pyrimidine/purine cysteinyl-[lipoprotein] glutamyl-[protein] hexyl-thiohydroximate cysteinyl-[protein] enoyl-CoA D-xylopyranose cis-aconitate nucleoside- ribonucleoside- E4664_RS13295 xanthine E4664_RS12610 methylcitrate bifunctional dTDP nucleoside phosphorylase: L-valine degradation I diphosphate diphosphate E4664_RS13305 phosphoribosyltransferase: nucleoside- nucleoside triphosphate L-threonine L-isoleucine degradation I L-arginine degradation phosphoribosylaminoimidazolecarboxamide guanosine E4664_RS15150 L-leucine degradation I kinase: reductase: formyltransferase/IMP cyclohydrolase: purH E4664_RS19280 nucleoside-diphosphate diphosphate xanthine pyrophosphohydrolase: degradation I II (AST pathway) FGAR (Z)-1-(L-cystein-S 6-trans-3-oxo- (2R,3S)-3- a [protein]- E4664_RS14260 E4664_RS13295 dADP kinase: E4664_RS14260 kinase: mazG an L-arginyl- S-fenclorimyl- π + xanthine val indolylmethylisothiocyanate glutathione isovalerate an N-terminal L- -yl)-N-hydroxy-2- glutathione a protein with 3-methylmuconolactone N -phospho- NAD E4664_RS13305 FAICAR IMP E4664_RS14260 dUTP dUMP ile [tRNA Arg ] L-cysteine tridecenoyl-CoA isopropylmalate dTTP phosphoribosyltransferase: leu thr arg glutathione S-transferase: acetate--CoA aspartyl-[protein] phenylethan-1-imine acetyl-CoA C- a disulfide bond L-histidine nucleoside- phosphoribosylformylglycinamidine branched-chain arginyltransferase: cystathionine cystathionine glutaredoxin muconolactone 3-isopropylmalate bifunctional CTP guanine E4664_RS19280 branched-chain branched-chain threonine arginine N- E4664_RS08750 ligase: acs acyltransferase phosphohistidine NAD(+) kinase: diphosphate synthase: purL amino acid E4664_RS12675 beta-lyase: beta-lyase: 3: grxC Delta- dehydrogenase: GTP phosphoribosylaminoimidazolecarboxamide adenine and 5-hydroxy-CTP 5-hydroxy-CMP amino acid amino acid ammonia-lyase: succinyltransferase: [+ 6 isozymes] an N-terminal FadA: fadA a protein with phosphatase: E4664_RS03675 kinase: transaminase: E4664_RS19010 E4664_RS19010 isomerase: catC leuB dGDP formyltransferase/IMP cyclohydrolase: purH adenosine FGAM hypoxanthine transaminase: transaminase: E4664_RS00700 astA L-arginiyl-L- a tRNA Arg (Z)-2-phenyl-1- 6-chloro-2-phenyl- 4-trans- reduced L- GSSG E4664_RS03825 XMP E4664_RS00125 indol-3-ylmethylisothiocyanate-glutathione isovaleryl-CoA AMP diphosphate pyruvate pyruvate acetyl-CoA 4-methyl-3-oxoadipate- 4-methyl-2- E4664_RS14260 salvage VI E4664_RS00125 E4664_RS00125 (S)-3-methyl-2- undecenoyl-CoA a [protein]- NADP + phosphoribosyltransferase: hpt 4-methyl-2- threonine arginine N- aspartyl-[protein] thioacetohydroximate 4-sulfanylpyrimidine cysteine residues enol-lactone oxopentanoate nucleoside- phosphoribosylformylglycinamidine xanthine 3-methyl-2- oxopentanoate oxopentanoate L-histidine dATP IMP ammonia- succinyltransferase: diphosphate adenosine cyclo-ligase: purM phosphoribosyltransferase: oxobutanoate lyase, N 2 -succinyl-astA kinase: β β adenosine kinase: E4664_RS19280 biosynthetic: L-arginine 5,10-methylene- 3-methyl-2- N-acetyl- -D-glucosamine- an N-acetyl- - (E)-1-(L-cystein-S-yl)-N- S-(4-hydroxy- (2E,5Z)- a [protein]- E4664_RS14260 AIR ω a uracil in DNA FMN NADH H + 2-phosphoglycolate τ 7,8-dihydropterin E4664_RS06220 ilvA tetrahydromethanopterin oxobutanoate 1,6-anhydro-N- D-hexosaminide hydroxy- -(methylsulfanyl) 2-methylpentan- dodecenoyl-CoA N -phospho- (2Z)-2-aminobut- 2-methylbutanoyl-CoA N-succinylarginine β beta-N- GMP isovaleryl-CoA 3-methyl-2-oxobutanoate acetyl- -D-muramatebeta-N- octan-1-iminecystathionine 2-yl)-L-cysteinecystathionine uracil-DNA flavin reductase: phosphoglycolate enol-CoA L-histidine guanine dGTP AMP 2-enoate dihydrolase: astB acetylhexosaminidase: phosphohistidine isobutanoyl-CoA hydroxymethyltransferase: acetylhexosaminidase: beta-lyase: beta-lyase: glycosylase: E4664_RS07215 phosphatase: hydratase: deaminase: isovaleryl-CoA 2 panB nagZ E4664_RS08325 [+ 3 isozymes] phosphatase: N -succinyl- nagZ β E4664_RS19010 E4664_RS19010 E4664_RS15405 E4664_RS01890 guaD dehydrogenase: an N-acetyl- - ω an apyrimidinic + E4664_RS03825 L-ornithine THMPT 2-dehydropantoate 1,6-anhydro-N- an alcohol (E)- -(methylsulfanyl) 4-methyl-4- uracil NAD FMNH (S)-3-hydroxy-(5Z) 7,8- GlcNAc D-hexosamine pyruvate pyruvate site in DNA 2 a [protein]- E4664_RS09365 (E)-2- acetyl-β-muramate octyl-thiohydroximate sulfanylpentan-2-ol glycolate 2-iminobutanoate -dodecenoyl-CoA L-histidine dihydrolumazine 3-methylcrotonyl- methylcrotonoyl-CoA methylacrylyl-CoA CoA enol-CoA N 2 -succinyl- enol-CoA methylcrotonoyl- hydratase: L-glutamate 5- a 2,3,4-saturated (6Z,9Z,12Z,15Z,18Z)-3- (2E,6E)-farnesyl (11Z)-3- 3-oxo-(11Z)- (2R,3S)-3- a [protein]- protoheme tributyrin 4-nitrocatecholsulfate sec hydratase: CoA carboxylase: E4664_RS01890 semialdehyde 4'-phosphopantetheine ATP CTP 1,2-diacyl-sn- oxotetracosapentaenoyl-CoA diphosphate oxohexadecenoyl- octadecenoyl-CoA isopropylmalate N-phospho- a tRNA ser E4664_RS09370 2-oxobutanoate (2S,3S)-3-hydroxy-2- glycerol 3-phosphate acetyl-CoA C- protoheme IX CoA acetyl-CoA C- triacylglycerol 3-isopropylmalate L-histidine E4664_RS01890 succinylglutamate- phosphatidate acetyl-CoA C- sulfatase: phosphohistidine serine--tRNA methylbutanoyl-CoA pantetheine-phosphate acyltransferase farnesyltransferase: acyltransferase lipase: dehydratase: (S)-3-hydroxy- acetyl/propionyl/ semialdehyde cytidylyltransferase: acyltransferase E4664_RS09905 phosphatase: ligase: serS methylcrotonyl- dehydrogenase: adenylyltransferase: coaD E4664_RS05925 FadA: fadA cyoE FadA: fadA FadA: fadA E4664_RS18620 leuD leuC isobutanoyl-CoA 3'-dephospho-CoA a CDP-2,3,4-saturated- (4Z,7Z,10Z,13Z,16Z)- (9Z)- E4664_RS03825 an L-seryl-[tRNA sec ] CoA carboxylase astD acetyl-CoA ferroheme o acetyl-CoA palmitoleoyl-CoA acetyl-CoA butanoate 1,2-dibutyrin (2S)-2- diacylglycerol docosapentaenoyl-CoA tetradecenoyl-CoA 4-nitrocatechol a [protein]- subunit alpha: 2 isopropylmalate propanoyl-CoA N - L-histidine E4664_RS09380 2-methylacetoacetyl-CoA succinylglutamate (S)-3-hydroxy- 3-methylglutaconyl- isobutanoate acetyl-CoA C- succinylglutamate UDP-N-acetyl-α-D-muramoyl- 7,8-dihydrofolate an N-terminal S-(6-hydroxy- 3-oxo-(7Z)- 3-oxopalmitoyl- (R)-3- CoA + an L-arginyl- acyltransferase desuccinylase: astE γ D-alanyl-D-alanine O-acetyl-L-serine hydrogen selenide NADPH H 3-sulfino-L- 4-methylhexan- a cis-2-enoyl-CoA asp urea-1-carboxylate 3-hydroxyisobutyrate L-alanyl- -D-glutamyl-L-lysine monoglutamate [tRNA Arg ] tetradecenoyl-CoA CoA hydroxybutanoate FadA: fadA UDP-N-acetylmuramoyl- dihydrofolate alanyl-[protein] 4-yl)-L-cysteine acetyl-CoA C- acetyl-CoA C- allophanate dehydrogenase: propanoyl cysteine synthase arginyltransferase: cystathionine 3-hydroxybutyrate enol-CoA glu tripeptide--D-alanyl-D- reductase: acyltransferase acyltransferase aspartate hydrolase: mmsB phosphate CysM: cysM E4664_RS12675 beta-lyase: dehydrogenase: hydratase: propanoyl-CoA acetyl-CoA alanine ligase: murF E4664_RS14465 an N-terminal L- FadA: fadA FadA: fadA dehydrogenase: atzF (S)-methylmalonate- α E4664_RS19010 E4664_RS07255 E4664_RS01890 HMG-CoA acetate kinase: UDP-N-acetyl- -D-muramoyl-L-alanyl- + 5,6,7,8- Arg (5Z)- E4664_RS12220 acetate L-selenocysteine NADP arginiyl-3-sulfino- a tRNA 3-methyl-3- acetyl-CoA myristoyl-CoA acetyl-CoA a (3R)-3- CO ammonium semialdehyde E4664_RS14330 γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine tetrahydrofolate pyruvate dodecenoyl-CoA acetoacetate 2 hydroxymethylglutaryl- L-alanyl-[protein] sulfanylhexan-1-ol hydroxyacyl-CoA oxaloacetate CoA lyase: propanoate E4664_RS09385 L-proline degradation an N-terminal S-(4-hydroxy- a peptide with L-tryptophan degradation to a proteinogenic (5Z,8Z,11Z,14Z,17Z) RNase R degradation an L-arginyl- 5-cis, 7-trans-3-oxo- L-gulono- (S)-3-amino-2- hydrogencarbonate acetoacetate glutathione coenzyme A 3-sulfo-L- 3-methylbutan- a 3-oxoacyl-CoA an N-terminal hydroxypyruvate pro amino acid -icosapentaenoate substrate RNA [tRNA Arg ] tetradecadienoyl-CoA 1,4-lactone methylpropanoate 2-amino-3-carboxymuconate acyl-CoA synthetase: ribonuclease 2-yl)-L-cysteine acetyl-CoA C- acetyl-CoA C- SMP-30/ gamma- alanyl-[protein]arginyltransferase: cystathionine L-methioninetype I methionyl hydroxypyruvate semialdehyde trifunctional E4664_RS13800 R: rnr acyltransferase acyltransferase gluconolactonase/ glutamyltransferase: ggt E4664_RS12675 beta-lyase: aminopeptidase: isomerase: transcriptional α γ a nucleoside 5'- an N-terminal L- FadA: fadA FadA: fadA trp an -( -L-glutamyl) [+ 3 isozymes] a diribonucleotide E4664_RS19010 map E4664_RS13890 LRE family protein: regulator/proline L-cysteinylglycine (5Z,8Z,11Z,14Z,17Z) monophosphate arginiyl-3-sulfo- a tRNA Arg 2-methyl-3- (3Z,5E)-dodec- -L-amino acid pyruvate acetyl-CoA acetyl-CoA an acyl-CoA tartronate E4664_RS06795 L-tyrosine degradation I dehydrogenase/L- -icosapentaenoyl-CoA L-alanyl-[protein] sulfanylbutan-1-ol 3,5-dienoyl-CoA a peptide met L-histidine degradation I semialdehyde L-gulonate N-Formyl-L- glutamate gamma- semialdehyde tyr kynurenine dehydrogenase: a Chi-site containing a dimer of adjacent an S-(1-hydroxy- his aspartate/ a proteinogenic an L-arginyl- 3-oxopentanoyl- 3-oxomyristoyl- (2E,9Z)- putA leukotriene-C4 double stranded RecA 2'-deoxycytidine and hν a protein felinine (R)-glycerate 2-oxopropyl) histidine (S)-1-pyrroline- Arg CoA CoA hexadecenoyl-CoA tyrosine/aromatic amino acid [tRNA ] acetyl-CoA C- acetyl-CoA C- ammonia- 5-carboxylate DNA with a blunt end thymidine in DNA cystathionine enol-CoA D-glycerate -[protein]- aminotransferase: gamma- exodeoxyribonuclease deoxyribodipyrimidine arginyltransferase: acyltransferase acyltransferase lyase: hutH beta-lyase: hydratase: dehydrogenase: L-cysteineprotein 3-(4-hydroxyphenyl)E4664_RS16370 L-kynurenine glutamyltransferase: ggt a double strandedV DNA subunit alpha: recD photo-lyase: phrB E4664_RS12675 FadA: fadA FadA: fadA urocanate an α-(γ-L-glutamyl) adjacent 2'-deoxycytidine- E4664_RS19010 E4664_RS01890 E4664_RS03985 deglycase leukotriene-D4 an N-terminal Arg pyruvate -L-amino acid with a RecA protein thymidine in DNA a tRNA 3-methyl-3- propanoyl-CoA acetyl-CoA acetyl-CoA lauroyl-CoA HchA: hchA urocanate arginyl-[protein] pyruvate (S)-3-hydroxy-(9Z) a [protein]- 4-hydroxyphenylpyruvate loaded 3' overhang sulfanylbutan-1-ol hydroxypyruvate (R)-lactate hydratase: L-glutamate-5- -hexadecenoyl-CoA L-cysteine dioxygenase: hppD hutU semialdehyde 4-imidazolone- 3-hydroxy- trifunctional homogentisate a single- (6Z,9Z,12Z,15Z,18Z,21Z)-3- a dimer of adjacent a dimer of non- 4-trans-3-oxo- 3-oxo-(5Z)- (2E,11Z)- a phosphate 5-propanoate L-kynurenine transcriptional ν (R)-glycerate stranded RNA oxotetracosahexaenoyl-CoA pyrimidine h adjacent 2'- ν a type IV prepilin undecenoyl-CoA dodecenoyl-CoA octadecenoyl-CoA regulator/proline h monoester imidazolonepropionase: kynureninase: polyribonucleotide acetyl-CoA C- nucleosides in DNA deoxycytidines acetyl-CoA C- acetyl-CoA C- enol-CoA D-glycerate dehydrogenase/L- deoxyribodipyrimidine prepilin peptidase: alkaline E4664_RS17290 kynU nucleotidyltransferase: pnp acyltransferase in DNA deoxyribodipyrimidine acyltransferase acyltransferase hydratase: dehydrogenase: glutamate gamma- photo-lyase: phrB E4664_RS15130 phosphatase: a nucleoside a single- FadA: fadA two adjacent pyrimidine photo-lyase: phrB FadA: fadA FadA: fadA E4664_RS01890 E4664_RS03985 4-maleyl-acetoacetate semialdehyde (4Z,7Z,10Z,13Z,16Z,19Z) a 2'-deoxycytidine a cleaved type 2-trans- (3Z)-dec-3- E4664_RS01335 N-formimino- 3-hydroxyanthranilate diphosphate stranded RNA acetyl-CoA nucleosides in DNA a peptide acetyl-CoA acetyl-CoA (S)-3-hydroxy-(11Z) dehydrogenase: -docosahexaenoyl-CoA in DNA IV prepilin nonenoyl-CoA enoyl-CoA hydroxypyruvate L-glutamate -octadecenoyl-CoA an alcohol maleylacetoacetate putA formimidoylglutamase: isomerase: maiA hutG 2-amino-3- glu a dimer of non- an [RNA] 4-fumaryl-acetoacetate (E)-1-(L-cystein-S-yl)-N-hydroxy- γ-L-glutamyl-(S)- an L-cysteinyl- 3,22-dioxochol- carboxymuconate- glutathione hypoglycin A [DNA] adjacent pyrimidine hν containing gly a phosphatidylcholine 3-ethylmalate ω-(methylsulfanyl)butan-1-imine 2-aminobutanoate [tRNA Cys ] 4-en-24-oyl-CoA glu 6-semialdehyde exodeoxyribonuclease nucleosides in DNA cystathionine cytidine phospholipase D: fumarylacetoacetase: gamma- deoxyribodipyrimidine ribonuclease I: glutathione aminoacyl-tRNA 3-isopropylmalate acetyl-CoA C- III: xth beta-lyase: E4664_RS00195 fahA glutamyltransferase: ggt a 2'- photo-lyase: phrB E4664_RS19320 synthase: gshB a 1,2-diacyl- hydrolase: dehydrogenase: acyltransferase [+ 2 isozymes] a pyrimidine E4664_RS19010 a 5'-hydroxy- an [RNA]-3'- E4664_RS12875 leuB FadA: fadA glycine cleavage L-cysteinylglycine hypoglycin B deoxyribonucleoside [DNA] (E)-ω-(methylsulfanyl) ribonucleotide- cytidine-3'- ophthalmate choline sn-glycerol nucleoside in DNA pyruvate Cys 3-oxo-4-pregnene- 5'-monophosphate butyl-thiohydroximate 3-phosphate a tRNA cys 2-oxovalerate fumarate acetoacetate 3'-[RNA] phosphate 20-carboxyl-CoA L-phenylalanine a [glycine-cleavage degradation II (anaerobic) L-threonine complex H protein] degradation III (to N 6 -lipoyl-L-lysine a dimer of non-adjacent an intrastrand non- a dimer of a 1-acyl-2-arachidonoyl- 3-oxo-(9Z)- a dipetide with an N- (2E,7Z)- methylglyoxal) glycine glycine ν ν ν protoheme an aryl sulfate phe 2'-deoxycytidine and h adjacent cyclobutane h non-adjacent h phosphatidylcholine hexadecenoyl-CoA terminal L-aspartate tetradecenoyl-CoA glu ala L-methionine degradation cleavage cleavage thr thymidine in DNA thymidine dimer in DNA thymidines in DNA phospholipase D: acetyl-CoA C- ferrochelatase: dipeptidase: enol-CoA glutamate-- aspartate/ I (to L-homocysteine) system system deoxyribodipyrimidine deoxyribodipyrimidine deoxyribodipyrimidine sulfatase: E4664_RS00195 acyltransferase E4664_RS14865 E4664_RS07115 hydratase: cysteine ligase: tyrosine/aromatic protein protein photo-lyase: phrB photo-lyase: phrB photo-lyase: phrB a 1-acyl-2- E4664_RS09905 a 2'-deoxycytidine a DNA with FadA: fadA 2+ a proteinogenic aminotransferase: GcvH: gcvH a thymidine in DNA a thymidine in DNA choline arachidonoyl-sn- Fe protoporphyrin IX asp E4664_RS01890 E4664_RS17505 met GcvH: gcvH in DNA nonadjacent thymidines (7Z)- acetyl-CoA amino acid γ-L-glutamyl- E4664_RS16370 L-2-amino-3- a [glycine-cleavage glycerol 3-phosphate (S)-3-hydroxy-(7Z) 3-phenyl-2- methionine [+ 3 isozymes]a [glycine-cleavage tetradecenoyl-CoA D-alanine a phenol oxopropanoate oxobutanoate complex H protein] N 6 - -tetradecenoyl-CoA adenosyltransferase: complex H protein] N 6 aminomethyldihydrolipoyl- E4664_RS08575 -dihydrolipoyl-L-lysine L-lysine a dimer of non-adjacent a dimer of adjacent SAM S-(2-hydroxyacyl) a dietary all- N-acetyl-D- an L-cysteine- thymidine and 2'- hν thymidine and 2'- hν a ribonucleic acid canavaninosuccinate asp fumarate propionamide glutathione trans-retinyl ester mannosamine S-conjugate phenylacetaldehyde aminoacetone deoxycytidine in DNA deoxycytidine in DNA hydroxyacylglutathione ribonuclease PH: triacylglycerol argininosuccinate cystathionine deoxyribodipyrimidine deoxyribodipyrimidine L-aspartate N-acetylneuraminate amidase: glycine hydrolase: gloB E4664_RS16565 lipase: lyase: argH beta-lyase: L-tryptophan photo-lyase: phrB photo-lyase: phrB oxidase: nadB synthase: neuB E4664_RS06510 NAD-dependent primary- cleavage a 2'-deoxycytidine adjacent thymidine-2'- a 2-hydroxy glutathione a nucleoside E4664_RS18620 fumarate L-canavanine E4664_RS19010 degradation I L-serine degradation a thymidine in DNA a ribonucleic acid succinate 2-iminosuccinate β phenylacetaldehyde amine system in DNA deoxycytidine in DNA carboxylate diphosphate a fatty acid all-trans-retinol N-acetyl- - SAH (via anthranilate) pyruvate a thiol propanoate dehydrogenase: oxidase: protein neuraminate E4664_RS06570 tynA trp ser adenosylhomocysteinase: GcvH: gcvH phenylacetate methylglyoxal L-serine E4664_RS02865 6 a peptide with ammonia-lyase: a double a dimer of adjacent ν an N -(1-hydroxy-2- an [RNA] 4-nitrophenyl O-ureido-L- (2R,3S)-2- penicillin G h asp methylglyoxal N-Formyl-L- E4664_RS09695 stranded DNA thymidines in DNA oxopropyl)-[protein]-L-lysine containing uridine butanoate homoserine methylisocitrate an N-terminal L-homocysteine 2-aminoprop- ribonuclease I: kynurenine DNA exonuclease: penicillin G amidase: deoxyribodipyrimidine protein deglycase arylesterase: argininosuccinate methylisocitrate L-alanine aminopeptidase 2-enoate E4664_RS03535 E4664_RS06575 photo-lyase: phrB HchA: hchA E4664_RS19320 E4664_RS12075 lyase: prpB glyoxalase: a single two adjacent a 5'-hydroxy- an [RNA]-3'- synthase: argG N: pepN E4664_RS12250 D-serine degradation a 5'-phosphomononucleotide phenylacetate 6-aminopenicillanate (R)-lactate a [protein]-L-lysine butanoate 4-nitrophenol pyruvate succinate L-glutamate stranded DNA thymidines in DNA ribonucleotide- uridine-3'- canavaninosuccinate a peptide ala degradation II 3'-[RNA] phosphate (R)-lactate L-kynurenine L-aspartate D-serine 2-iminopropanoate degradation I D-serine glu kynureninase: UTP ammonia-lyase: aspartate/ glutathione glycyl-glycine a dimer of adjacent 2'- hν 7,8- protoheme chitin 4-nitrophenyl a phenyl acetate phenyl acetate γ-L-glutamyl- kynU asp deoxycytidines in DNA dihydromonapterin palmitate gly 2-aminoprop-E4664_RS12130 tyrosine/aromatic beta-N- nucleoside triphosphate D-alanine aminotransferase: aspartate/ gamma- deoxyribodipyrimidine dihydroneopterin heme oxygenase: arylesterase: arylesterase: arylesterase: glutathione 2-enoate anthranilate pyruvate acetylhexosaminidase: pyrophosphohydrolase: E4664_RS16370 tyrosine/aromatic glutamyltransferase: ggt photo-lyase: phrB aldolase: folB E4664_RS12410 E4664_RS12075 mazG E4664_RS12075 E4664_RS12075 synthase: γ-L-glutamyl- two adjacent 2'- 6-(hydroxymethyl) (Z,Z)- nagZ asp aminotransferase: L-cysteinylglycine glycolaldehyde CO Fe 2+ N-acetyl-D- palmitate 4-nitrophenol acetate a phenol acetate phenol gshB glycylglycine deoxycytidines in DNA -7,8-dihydropterin biliverdin-IX α UMP L-glutamine E4664_RS16370 glucosamine chitin norophthalmate degradation I aspartate oxaloacetate 2-iminopropanoate ammonia-lyase: gln E4664_RS07315 glutaminase: fumarate E4664_RS12190 pyruvate [+ 5 isozymes] glu

a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA

RS13800 RS14765 RS15800 RS06740

a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate

This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.