Case Report Allogeneic Bone Marrow Transplantation for Advanced Waldenstrom’S Macroglobulinemia
Bone Marrow Transplantation, (1999) 23, 747–749 1999 Stockton Press All rights reserved 0268–3369/99 $12.00 http://www.stockton-press.co.uk/bmt Case report Allogeneic bone marrow transplantation for advanced Waldenstrom’s macroglobulinemia R Martino1, A Shah2, P Romero1, S Brunet1, J Sierra1, A Domingo-Albo´s1,✠, S Fruchtman2 and L Isola2 1Clinical Hematology Division, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; and 2Division of Hematology, Mount Sinai Medical Center, New York City, NY, USA Summary: Patients and methods Waldenstrom’s disease is a lymphoproliferative dis- Case 1 order that is typically treated with plasmapheresis and/or alkylating agents. In young patients, other A 34-year-old female was diagnosed in October 1986 with lymphoproliferative disorders have been treated with Waldenstrom’s macroglobulinemia. The patient presented allogeneic transplantation. Two patients with aggressive with autoimmune hemolytic anemia, a monoclonal IgM Waldenstrom’s disease, who progressed in spite of kappa of 17 g/l, kappa light chains in the urine, involve- multi-agent chemotherapy and autologous stem cell ment of bone marrow, peripheral blood, liver and spleen transplantation, in one case, underwent allogeneic and generalized lymphadenopathy. Lymph node biopsy transplantation from their HLA-identical donors. Both showed diffuse small lymphocytic lymphoma with lympho- remain alive with event-free survivals of more than 3, plasmacytic differentiation. Initial treatment was chloram- and more than 9 years, respectively. Allogeneic trans- bucil, steroids and splenectomy. In January 1988 the patient plantation should be considered for young patients with received combination chemotherapy with CHOP (cyclo- Waldenstrom’s disease. phosphamide, vincristine, adriamycin and prednisone), for Keywords: allogeneic; bone marrow transplant; Walden- a total of six cycles with no response.
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