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Carey Nat Pope

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Carey Nat Pope CAREY NAT POPE College of Veterinary Medicine Oklahoma State University 264 McElroy Hall Stillwater, OK 74078 [email protected] (405)744-6257 (fax)744-4345 EDUCATION 1981-1985 University of Texas Graduate School of Biomedical Sciences, Houston, TX. Degree: Ph.D. (Pharmacology/Toxicology). 1977-1979 Stephen F. Austin State University, Nacogdoches, TX. Degree: M.S. (Biology). 1974-1976 Stephen F. Austin State University, Nacogdoches, TX. Degree: B.S. (Biology). 1971-1973 University of Houston, Houston, TX. EXPERIENCE 12/2015-present Adjunct Professor, Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 10/2014-present Adjunct Professor, Department of Integrative Biology, Oklahoma State University, Stillwater, OK 3/2013-present Director, Graduate Certificate Program in Interdisciplinary Toxicology, Oklahoma State University, Stillwater, OK. 6/2012-present Director, Interdisciplinary Toxicology Program, Oklahoma State University, Stillwater, OK. 7/1/2006-1/31/2012 Head, Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK. 8/1/2005-6/30/06 Interim Head, Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK. 1/2000-present Professor and Sitlington Endowed Chair in Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK. 8/95-12/99 Director, Division of Toxicology, College of Pharmacy and Health Sciences, University of Louisiana at Monroe, Monroe, LA. Division included five full-time tenured or tenure-track members and one instructor and was responsible for implementing B.S., M.S. and Ph.D. degree programs in Toxicology. 12/93-12/99 Director, B.S. Toxicology Program, College of Pharmacy and Health Sciences, University of Louisiana at Monroe, Monroe, LA. Administrative head of undergraduate degree-granting program in toxicology. 7/98-12/99 Professor of Toxicology, College of Pharmacy and Health Sciences, University of Louisiana at Monroe, Monroe, LA 8/93-6/98 Associate Professor of Toxicology, College of Pharmacy and Health Sciences, Northeast Louisiana University, Monroe, LA. 7/89-8/93 Assistant Professor, Division of Pharmacology and Toxicology, Northeast Louisiana University, Monroe, Louisiana. 7/86-6/89 National Academy of Sciences (NRC) Research Associate, Division of Neurotoxicology, US EPA, Research Triangle Park, NC. Research on the mechanism of toxicity of organophosphorus compounds, phospholipid metabolism, protein purification. 1/86-6/86 Postdoctoral Fellow, Department of Neurology, Baylor College of Medicine, Houston, TX. Isolation and characterization of protein involved in calcium-dependent potassium transport in erythrocytes. 5/83-12/85 Predoctoral Fellow, Neurochemistry Section, Texas Research Institute of Mental Sciences. Doctoral research on the neuropharmacological basis of learning and memory in mice using cholinergic drugs and neurotoxins. 1/82-10/82 Research Assistant III, Neurology Department, Baylor College of Medicine, Houston, TX. Protein purification, polyacrylamide gel electrophoresis, enzymatic assays. 1/80-8/81 Research Assistant II, Developmental Therapeutics, M.D. Anderson Hospital and Tumor Institute, Houston, TX. Enzymology, biochemical assay development, chromatography, autoradiography. SPECIAL POSITIONS/APPOINTMENTS 11/2019-present Chair, Environmental Health Sciences Review Committee, NIEHS. 9/2018-present Member, Research Advisory Committee on Gulf War Veterans’ Illnesses, U.S. Department of Veterans Affairs, Washington, DC. 7/2016-present Fellow, Academy of Toxicological Sciences 2 7/14-present Member, External Advisory Board, University of California CounterACT Center. Davis, CA. 7/08-6/12 Member, Scientific Advisory Panel, U. S. Environmental Protection Agency, Washington, DC. 7/07-present Regents Professor, Oklahoma State University, Stillwater, OK. 3/05-present Honorary Member, Nu Chapter of Phi Zeta, Oklahoma State University Center for Veterinary Health Sciences, Stillwater, OK 1/00-present Sitlington Endowed Chair in Toxicology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK. 2000-2004 Member, External Advisory Board, Oklahoma Center for Toxicology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. 7/96-12/99 Waste Management Endowed Professor of Toxicology, College of Pharmacy and Health Sciences, University of Louisiana, Monroe, LA 3/94-12/99 Member, Louisiana Advisory Commission on Pesticides. Adviser to the Commissioner of Agriculture and Forestry on pesticide-related issues, Baton Rouge, LA. 6/97-8/97 Consultant, Office of the Special Assistant for Gulf War Illnesses, Secretary of Defense, Washington, D.C. 11/96-present Member, Food Quality Protection Act (FQPA) Board, U.S. Environmental Protection Agency, Washington, D.C. 11/01-2/05 Member, Subcommittee on Toxicologic Assessment of Low-Level Exposures to Chemical Warfare Agents, National Research Council, Washington, DC. 10/01-10/03 Visiting Professor, Sun Yat-Sen University of Medical Sciences, Guangzhou, China. RESEARCH PROPOSALS AND FUNDING-total to date >$12.5M. 11/1/19-10/31/20 PI on internal grant 5-150060 through College of Veterinary Medicine entitled CB2 signaling and acute DFP intoxication. This project studies acute and delayed consequences of DFP and its possible modulation with cannabinoid CB2 receptor activation. 7/1/20-6/30/23 Co-PI (with A. Ray and A. Kanthasamy) on U01-10016139 application entitled “CB2 signaling and delayed sequelae of acute DFP intoxication. Submitted 9/10/2019. 3 9/1/17-8/31/22 Co-investigator (P. Laurienti, PI) on RO1 ES008739-20 entitled “CBPR on Pesticide Exposure and Neurological Outcomes for Latinos: PACE5”. This is a multi- institutional project to study neurological effects in pesticide applicators and their children. OSU direct support $132,585. Completed and non-funded applications 10/1/18-3/31/18 Co-investigator (A. Ray, PI) on Defense Threat Reduction Agency, Department of Defense, Chemical and Biological Defense Program Phase I proposal (SBIR) entitled “Extended Release of Pyridostigmine Bromide for Effectively Combating Nerve Agent Exposure”, W911QY-18-C-0200. Funded. OSU direct support $47,985. 8/12/13 - 11/11/17 Principal investigator on DOD Defense Threat Reduction Agency proposal entitled “Nanocarrier-mediated Targeting of Bioscavengers to the Red Blood Cell for Prolonged Circulation and Protection”, HDTRA1-13-1-0042. Funded, total funds $3,297,545. 9/1/17-8/31/21 Principal investigator on invited Phase II proposal to DTRA (HDTRA117- CBS-01-2-0034) entitled “Enhancing bioscavenger catalysis and efficacy”. This is a multi-institutional application with co-investigators at Oak Ridge National Laboratory (Pratul Agarwal), OSU Entomology and Plant Pathology (Haobo Jiang) and OSU Center for Veterinary Health Sciences (Jing Liu). Total requested support $3,583,897. Not funded (nor was any other funded in this cycle). 9/1/17 – 8/31/21 Principal investigator on Phase I proposal to DTRA entitled “Enhancing bioscavenger catalysis and efficacy”. DTRA requested a Phase II proposal based on the Phase I. 11/1/1/15 – 10/30/16 Principal investigator on OSU internal team-building grant entitled “Increasing the Catalytic Efficiency of Butyrylcholinesterase by Surface Loop Modification: Insights into Structure-Dynamics-Function Relationships”, AE-1-50060. Funded, total funds $34,000. 8/17/15-8/16/18 Principal investigator for EPA Cooperative Training Grant proposal entitled “Oklahoma Center for Interdisciplinary Toxicology”, GRANT11779983. Submitted November 11, 2014, not funded. Total funds requested $1,976,892. 7/19/11-11/30/15 Co-investigator (S. Katz, PI), NHLBI grant entitled “Augmentation of parasympathetic tone with pyridostigmine in heart failure”, R01 HL103988-03, funded. OSU support $134,670. 3/1/09-2/28/15 Principal investigator, NIH grant (R01 ES009119-14). This is a continuation of prior grant “Presynaptic modulation of anticholinesterase toxicity” from National Institute of Environmental Health Sciences. Renewal application resubmission August 15, 2008, priority score 117 (0.4 percentile). Funded, total support $1,586,006. This grant ran continuously from August 1, 1998 to February 28, 2015. 3/1/2012-2/28/14 Co-investigator (T. Arcury, PI) on NIEHS application entitled “CBPR on Pesticide Exposure & Neurological Outcomes for Latinos: PACE4”, 5R01ES008739-14, funded (OSU support $117,851). 8/1/14-7/31/17 Principal investigator (for Oklahoma) on two-state (Oklahoma and South Carolina) NSF EPSCoR RII Track-2 consortium proposal entitled “Emerging Materials: 4 Redesign for Risk Minimization, #1430636. Submitted January 29, 2014. Total funds requested, $6,000,000 (not funded). 1/1/11-12/31/13 Co-investigator (S. Po, PI) on NIH R21 application entitled “Magnetic nanoparticles for the treatment of atrial fibrillation”. Submitted June 16, 2010, not funded. 3/1/13-2/28/14 Principal investigator on Center for Veterinary Health Sciences application entitled “Development of RBC-targeted nanodevice for long term protection against OPs, March 18, 2013. Funded, total funds $33,770. 10/1/10-9/30/12 Principal investigator on NINDS application entitled “Counteracting acute and persistent effects of organophosphate intoxication by endocannabinoids”. Submitted February 5, 2010. Funded, 5R21NS072085, $1M direct costs. 10/1/10-9/30/2013 Co-investigator (S. Katz, PI), NHLBI application entitled “Augmentation of parasympathetic tone
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