Carey Nat Pope

CAREY NAT POPE

College of Veterinary Medicine Oklahoma State University 264 McElroy Hall Stillwater, OK 74078

[email protected] (405)744-6257 (fax)744-4345

EDUCATION

1981-1985 University of Texas Graduate School of Biomedical Sciences, Houston, TX. Degree: Ph.D. (Pharmacology/Toxicology).

1977-1979 Stephen F. Austin State University, Nacogdoches, TX. Degree: M.S. (Biology).

1974-1976 Stephen F. Austin State University, Nacogdoches, TX. Degree: B.S. (Biology).

1971-1973 University of Houston, Houston, TX.

EXPERIENCE

12/2015-present Adjunct Professor, Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK

10/2014-present Adjunct Professor, Department of Integrative Biology, Oklahoma State University, Stillwater, OK

3/2013-present Director, Graduate Certificate Program in Interdisciplinary Toxicology, Oklahoma State University, Stillwater, OK.

6/2012-present Director, Interdisciplinary Toxicology Program, Oklahoma State University, Stillwater, OK.

7/1/2006-1/31/2012 Head, Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK.

8/1/2005-6/30/06 Interim Head, Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK.

1/2000-present Professor and Sitlington Endowed Chair in Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK.

8/95-12/99 Director, Division of Toxicology, College of Pharmacy and Health Sciences, University of Louisiana at Monroe, Monroe, LA. Division included five full-time tenured or tenure-track members and one instructor and was responsible for implementing B.S., M.S. and Ph.D. degree programs in Toxicology.

12/93-12/99 Director, B.S. Toxicology Program, College of Pharmacy and Health Sciences, University of Louisiana at Monroe, Monroe, LA. Administrative head of undergraduate degree-granting program in toxicology.

7/98-12/99 Professor of Toxicology, College of Pharmacy and Health Sciences, University of Louisiana at Monroe, Monroe, LA

8/93-6/98 Associate Professor of Toxicology, College of Pharmacy and Health Sciences, Northeast Louisiana University, Monroe, LA.

7/89-8/93 Assistant Professor, Division of Pharmacology and Toxicology, Northeast Louisiana University, Monroe, Louisiana.

7/86-6/89 National Academy of Sciences (NRC) Research Associate, Division of Neurotoxicology, US EPA, Research Triangle Park, NC. Research on the mechanism of toxicity of organophosphorus compounds, phospholipid metabolism, protein purification.

1/86-6/86 Postdoctoral Fellow, Department of Neurology, Baylor College of Medicine, Houston, TX. Isolation and characterization of protein involved in calcium-dependent potassium transport in erythrocytes.

5/83-12/85 Predoctoral Fellow, Neurochemistry Section, Texas Research Institute of Mental Sciences. Doctoral research on the neuropharmacological basis of learning and memory in mice using cholinergic drugs and neurotoxins.

1/82-10/82 Research Assistant III, Neurology Department, Baylor College of Medicine, Houston, TX. Protein purification, polyacrylamide gel electrophoresis, enzymatic assays.

1/80-8/81 Research Assistant II, Developmental Therapeutics, M.D. Anderson Hospital and Tumor Institute, Houston, TX. Enzymology, biochemical assay development, chromatography, autoradiography.

SPECIAL POSITIONS/APPOINTMENTS

11/2019-present Chair, Environmental Health Sciences Review Committee, NIEHS. 9/2018-present Member, Research Advisory Committee on Gulf War Veterans’ Illnesses, U.S. Department of Veterans Affairs, Washington, DC. 7/2016-present Fellow, Academy of Toxicological Sciences

2 7/14-present Member, External Advisory Board, University of California CounterACT Center. Davis, CA. 7/08-6/12 Member, Scientific Advisory Panel, U. S. Environmental Protection Agency, Washington, DC.

7/07-present Regents Professor, Oklahoma State University, Stillwater, OK.

3/05-present Honorary Member, Nu Chapter of Phi Zeta, Oklahoma State University Center for Veterinary Health Sciences, Stillwater, OK

1/00-present Sitlington Endowed Chair in Toxicology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK.

2000-2004 Member, External Advisory Board, Oklahoma Center for Toxicology, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

7/96-12/99 Waste Management Endowed Professor of Toxicology, College of Pharmacy and Health Sciences, University of Louisiana, Monroe, LA

3/94-12/99 Member, Louisiana Advisory Commission on Pesticides. Adviser to the Commissioner of Agriculture and Forestry on pesticide-related issues, Baton Rouge, LA.

6/97-8/97 Consultant, Office of the Special Assistant for Gulf War Illnesses, Secretary of Defense, Washington, D.C.

11/96-present Member, Food Quality Protection Act (FQPA) Board, U.S. Environmental Protection Agency, Washington, D.C.

11/01-2/05 Member, Subcommittee on Toxicologic Assessment of Low-Level Exposures to Chemical Warfare Agents, National Research Council, Washington, DC.

10/01-10/03 Visiting Professor, Sun Yat-Sen University of Medical Sciences, Guangzhou, China.

RESEARCH PROPOSALS AND FUNDING-total to date >$12.5M.

11/1/19-10/31/20 PI on internal grant 5-150060 through College of Veterinary Medicine entitled CB2 signaling and acute DFP intoxication. This project studies acute and delayed consequences of DFP and its possible modulation with cannabinoid CB2 receptor activation. 7/1/20-6/30/23 Co-PI (with A. Ray and A. Kanthasamy) on U01-10016139 application entitled “CB2 signaling and delayed sequelae of acute DFP intoxication. Submitted 9/10/2019.

3 9/1/17-8/31/22 Co-investigator (P. Laurienti, PI) on RO1 ES008739-20 entitled “CBPR on Pesticide Exposure and Neurological Outcomes for Latinos: PACE5”. This is a multi- institutional project to study neurological effects in pesticide applicators and their children. OSU direct support $132,585. Completed and non-funded applications 10/1/18-3/31/18 Co-investigator (A. Ray, PI) on Defense Threat Reduction Agency, Department of Defense, Chemical and Biological Defense Program Phase I proposal (SBIR) entitled “Extended Release of Pyridostigmine Bromide for Effectively Combating Nerve Agent Exposure”, W911QY-18-C-0200. Funded. OSU direct support $47,985. 8/12/13 - 11/11/17 Principal investigator on DOD Defense Threat Reduction Agency proposal entitled “Nanocarrier-mediated Targeting of Bioscavengers to the Red Blood Cell for Prolonged Circulation and Protection”, HDTRA1-13-1-0042. Funded, total funds $3,297,545. 9/1/17-8/31/21 Principal investigator on invited Phase II proposal to DTRA (HDTRA117- CBS-01-2-0034) entitled “Enhancing bioscavenger catalysis and efficacy”. This is a multi-institutional application with co-investigators at Oak Ridge National Laboratory (Pratul Agarwal), OSU Entomology and Plant Pathology (Haobo Jiang) and OSU Center for Veterinary Health Sciences (Jing Liu). Total requested support $3,583,897. Not funded (nor was any other funded in this cycle). 9/1/17 – 8/31/21 Principal investigator on Phase I proposal to DTRA entitled “Enhancing bioscavenger catalysis and efficacy”. DTRA requested a Phase II proposal based on the Phase I. 11/1/1/15 – 10/30/16 Principal investigator on OSU internal team-building grant entitled “Increasing the Catalytic Efficiency of Butyrylcholinesterase by Surface Loop Modification: Insights into Structure-Dynamics-Function Relationships”, AE-1-50060. Funded, total funds $34,000. 8/17/15-8/16/18 Principal investigator for EPA Cooperative Training Grant proposal entitled “Oklahoma Center for Interdisciplinary Toxicology”, GRANT11779983. Submitted November 11, 2014, not funded. Total funds requested $1,976,892. 7/19/11-11/30/15 Co-investigator (S. Katz, PI), NHLBI grant entitled “Augmentation of parasympathetic tone with pyridostigmine in heart failure”, R01 HL103988-03, funded. OSU support $134,670. 3/1/09-2/28/15 Principal investigator, NIH grant (R01 ES009119-14). This is a continuation of prior grant “Presynaptic modulation of anticholinesterase toxicity” from National Institute of Environmental Health Sciences. Renewal application resubmission August 15, 2008, priority score 117 (0.4 percentile). Funded, total support $1,586,006. This grant ran continuously from August 1, 1998 to February 28, 2015. 3/1/2012-2/28/14 Co-investigator (T. Arcury, PI) on NIEHS application entitled “CBPR on Pesticide Exposure & Neurological Outcomes for Latinos: PACE4”, 5R01ES008739-14, funded (OSU support $117,851). 8/1/14-7/31/17 Principal investigator (for Oklahoma) on two-state (Oklahoma and South Carolina) NSF EPSCoR RII Track-2 consortium proposal entitled “Emerging Materials:

4 Redesign for Risk Minimization, #1430636. Submitted January 29, 2014. Total funds requested, $6,000,000 (not funded).

1/1/11-12/31/13 Co-investigator (S. Po, PI) on NIH R21 application entitled “Magnetic nanoparticles for the treatment of atrial fibrillation”. Submitted June 16, 2010, not funded.

3/1/13-2/28/14 Principal investigator on Center for Veterinary Health Sciences application entitled “Development of RBC-targeted nanodevice for long term protection against OPs, March 18, 2013. Funded, total funds $33,770.

10/1/10-9/30/12 Principal investigator on NINDS application entitled “Counteracting acute and persistent effects of organophosphate intoxication by endocannabinoids”. Submitted February 5, 2010. Funded, 5R21NS072085, $1M direct costs.

10/1/10-9/30/2013 Co-investigator (S. Katz, PI), NHLBI application entitled “Augmentation of parasympathetic tone with pyridostigmine in heart failure”. Submitted November 2009. Received 21st percentile score.

7/1/10-6/30/11 Principal investigator, DoD application entitled “Chemical forensics for toxic chemicals and explosives”. Funded, HHM402-10-C0065, total funds $375,000.

10/1/09-9/30/11 Co-investigator (G. Chen, PI), NIH Challenge (RC1) application entitled “Neurological roles of sulfotransferases”. Submitted April 25, 2009. Not funded.

10/1/09-9/30/11 Principal investigator, NIH Challenge (RC1) application entitled “Gold core colloidal fullerene aggregates: novel modification to enhanced evaluation of mammalian toxicity. Submitted April 24, 2009. Not funded.

9/1/09-8/31/12 Co-investigator (K. Ausman, PI) on NSF application entitled “Nobel metal cored fullerene colloids for enhanced detection”. Submitted March 1, 2009. Not funded.

10/1/09-9/30/14 Co-investigator (G. Chen, PI) on 1R01OD006299-01 NIH Road Map Transformative grant application entitled “Biological Functions of Sulfotransferases”. Submitted February 4, 2009. Not funded.

4/1/09-3/31/11 Co-investigator (S. Po, PI) on NIH R21 application entitled “Magnetic nanoparticles for the treatment of atrial fibrillation”. Total OSU component, $48,736. Submitted 2/7/09. Not funded.

4/1/09-3/31/12 Co-investigator (R. Towner, PI) on OCAST application entitled “Pre-Clinical Investigation of Nitrone Anti-Glioma Agent”. Total OSU direct costs, $32,079. Not funded.

5 4/1/09-3/31/11 Co-investigator (S. Po, PI) on NIH R21 application entitled “Magnetic nanoparticles for the treatment of atrial fibrillation”. Total OSU component, $48,736. Submitted 6/13/08. Not funded.

10/1/08-9/30/11 Co-investigator (J. Steevens, PI) on project entitled “Do fullerene nanoparticles disrupt cholinergic and adrenergic neurotransmitter and receptor function in aquatic species?” U.S. Army Corps of Engineers. Total OSU component, $261,000. Submitted 3/08, not funded.

10/1/08-9/30/11 Principal investigator, NINDS grant application entitled “Endocannabinoid signaling and organophosphate toxicity”. Submitted 12/10/07, not funded.

9/1/07-8/31/09 Co-investigator (G. Zhang, PI), “Novel antimicrobial peptides as anti-sepsis drugs”, supported by Oklahoma Center for the Advancement of Science and Technology. This project evaluates efficacy of novel peptides against microbial infection and relative toxicity, funded with total support of $90,000.

7/1/08/6/30/13 Principal investigator for grant application (5R01 ES009119-09). This is a continuation of prior grant “Presynaptic modulation of anticholinesterase toxicity” from National Institute of Environmental Health Sciences. Renewal application submitted July 7, 2007. Initial score, 220. Not funded.

6/1/07-5/31/08 Co-Principal investigator (K. Ausman, co-PI), “Oxidative behavior of nanoparticles in biological systems”, supported by Oklahoma EPSCoR. This project supports two graduate students working in nanotoxicology, funded with total support of $56,642.

9/1/07-8/31/12 Co-principal investigator, NIH COBRE grant application (1 P20 RR021962- 01A1) entitled “Center for Comparative Medicine”, Oklahoma State University Center for Veterinary Health Sciences. Submitted 2/15/07, not funded (priority score, 1.86).

9/1/07-8/31/10 Co-PI (with Dr. Akhilesh Ramachandran) on project “Cellular and gene expression studies on CdTe Toxicity”, NIEHS. Submitted January 10, 2007, not funded.

10/1/06-9/30/11 Principal investigator on project (1U01 NS058106-01) entitled “Organophosphate toxicity: cannabinergic signaling as a therapeutic target” under NIH CounterACT program RFA. Submitted April 11, 2006, not funded.

10/1/05-9/30/06 Principal investigator in supplemental project (3R01 ES009119-07S1) under program “Medical Countermeasures to Chemical Terrorism”, NINDS/NIEHS. Funded, start date October 1, 2005, direct support, $50,000.

7/1/05-6/30/07 Co-investigator on project entitled “Evaluation of semiconductor nanoparticle toxicity in rats” (J. Liu, PI), U.S. Environmental Protection Agency. Submitted 1/5/05, not funded.

6/05-7/05 Principal investigator, conference grant application entitled “International Neurotoxicology Association”, U.S. Army Medical Research and Materiel Command. Submitted 12/7/04, not funded.

2/1/05-1/31/10 Co-principal investigator, NIH COBRE grant application (1 P20 RR021962-01) entitled “Center for Comparative Medicine”, Oklahoma State University Center for Veterinary Health Sciences. Submitted 10/4/2004, priority score, 2.5, not funded.

6/05-7/05 Principal investigator, NIH conference grant application (1 R13 ES013911-01) entitled “10th Meeting, International Neurotoxicology Association”. Submitted 8/1/04. Funded, total support $5,000.

7/1/05-7/31/07 Co-investigator on project entitled “Water-soluble nanoparticles for oxygen imaging in tumor” (1R43 CA112756-01, W. Chen, PI) with National Cancer Institute. Funded, total costs $100,000

1/1/05-8/28/08 Co-investigator on project entitled “Nanoparticle self-lighting photodynamic therapy for ovarian cancer treatment” (A043-187-0258, S. Wang, Chen, PI) with U.S. Army. Funded, total costs $300,000.

7/23/04-6/30/07 Co-investigator on project entitled “Scintillation luminescence system for in- vivo dosimetry” (1 R43 CA110091-01, W. Chen, PI) with National Cancer Institute. Funded, total costs $400,000.

7/1/04-6/30/08 Mentor on project entitled “Native Americans in Biologic Science” (R. Miller and G. John, co-PI), National Institutes of Health. Funded, multi-year training program.

4/1/04-3/30/07 Consultant on project entitled “Mechanisms of Alveolar Epithelial Cell Differentiation” (R01 HL071628, L. Liu, PI).

6/22/03-6/27/03 Principal investigator on conference grant entitled “Cholinesterase inhibitors: From Therapeutics to Terrorism” (DAMD17-03-1-0462) with U.S. Department of the Army. Funded, total costs $4,500.

7/1/04-6/30/07 Co-investigator on project entitled “Dietary sugar-induced modulation of organophosphate pesticides” (J. Liu, PI). Submitted to National Institute of Environmental Health Sciences, September 30, 2003. Requested funding, $585,977 (not funded).

9/22/03-6/30/08 Principal investigator for grant application (2R01 ES009119-05). This is a continuation of prior grant “Presynaptic modulation of anticholinesterase toxicity” from National Institute of Environmental Health Sciences. Resubmitted February 27, 2003. Initial scores, 240, 178, final score 160. Funded: start date September 22, 2003. Total funding $1,653,997.

7/1/-03-6/30/06 Co-investigator on project entitled “Effects of subclinical intoxication with anticholinesterases on pulmonary mechanical properties and susceptibility to acute asthma” (M. Davis, PI) supported by Oklahoma State University Presidential Grant program (total budget $75,000). One of five selected for funding but program was cancelled.

12/1/03-11/31/07 Principal investigator for grant application to U.S. Army entitled “Neurochemical and neurobehavioral effects of acute and repeated sarin or VX exposures in rats”. Submitted April 4, 2003. Requested funding, $1,398,429. Not funded.

4/1/03-3/31/05 Principal investigator for U.S. Army grant application entitled “Paraquat, organophosphates and Parkinson’s disease”. This project would evaluate possible mechanisms whereby some organophosphates may differentially modulate expression/progression of paraquat-induced dopaminergic neurotoxicity. Submitted 10/2/02, requested support, $975, 277. Not funded.

4/1/03-3/31/08 Principal investigator for grant application (2R01 ES09119-05). This is a continuation of prior grant “Presynaptic modulation of anticholinesterase toxicity” from National Institute of Environmental Health Sciences. Submitted November 1, 2001. Initial score, 240. Resubmitted June 25, 2002, requested support $1,699, 980. Priority score, 178.

3/1/01-2/28/03 Co-investigator on project entitled “Networked Terrorist Detection System” supported by U.S. National Institute of Justice (Memorial Institute for the Prevention of Terrorism). This project is for development of a networked microdetection system for chemical and biological agents. Proposal was approved and funded (co-investigator total budget, $302,175).

7/1/00-6/30/00 Principal investigator for Oklahoma State Department of Agriculture grant entitled “Potentiation of chemical-induced neuropathies”. This project evaluates the comparative sensitivity of neuropathies induced by organophosphates and ionophores to potentiation by the protease inhibitor phenylmethylsulfonyl fluoride. Proposal was approved and funded, ($5,000).

1/17/00-1/16/04 Principal investigator for grant (DAMD17-00-1-0070) “Stress, organophosphates and blood brain barrier integrity”, United States Army, Department of Defense. This project investigates the effects of prior physical stress or organophosphate exposure on blood brain barrier permeability and carbamate anticholinesterase toxicity. Proposal was approved and funded, start date 1/17/2000 ($886,491).

8/1/98 to 7/31/02 Principal investigator for grant (R01 ES09119) entitled “Presynaptic modulation of anticholinesterase toxicity”. National Institute of Environmental Health Sciences. This project expands the study of age-related differences in sensitivity to organophosphates from early development to aging and examines the roles of

8 acetylcholine synthesis and release in differential susceptibility. Proposal was approved and funded: start date August 1, 1998 ($596,080).

1/98 to 12/00 Principal investigator for grant (R825811) entitled “Age and interactive toxicity of organophosphorus insecticides”, United States Environmental Protection Agency. This three-year project examines mechanisms of interactive toxicity among organophosphorus anticholinesterases. Proposal was approved and funded: start date January 1, 1998 ($438,210).

10/92 to 9/96 Principal investigator for cooperative agreement with United States Environmental Protection Agency entitled "Neurotoxicity of organophosphate insecticides in developing and adult rats". This project is a continuation of the previous cooperative agreement and further examines long-term neurochemical/neurobehavioral changes induced by acute insecticide treatments both in adult and prenatal rats. Proposal was approved and funded ($260,000).

9/91 to 12/91 Principal investigator for contract with United States Environmental Protection Agency to study long-term neurochemical changes following organophosphate exposures. Proposal was approved and funded ($9,900).

10/89 to 10/91 Principal investigator for cooperative agreement with United States Environmental Protection Agency to study "age-related differences in sensitivity to cholinesterase inhibitors". Proposal was approved and funded ($160,000).

4/86-6/89 National Research Council Postdoctoral Fellowship. An independent proposal was accepted to characterize mechanisms of neurotoxicity. The work was conducted as an NRC postdoctoral associate at the United States Environmental Protection Agency Heath Effects Research Laboratory, Research Triangle Park, NC (1986-1989).

8/83 to 5/84 Toxicology Consultant, Exxon Chemical Americas, Houston, TX. Toxicological study which included experimental rationale and design, cost estimates for necessary equipment and supplies, and methods for interpretation of results. Proposal was approved and funded ($10,000).

TEACHING EXPERIENCE

1/02 to 6/15 Developed and currently instructor-of-record (IOR) for Advanced Toxicology (VBSC 6213, OSU (now Toxicology: From Molecules to Ecosystems, ITOX 6213, 2002-present). IOR for Physiology I in the veterinary curriculum (VMED 7114, 2010- 2011). Developed graduate course, Biochemical Toxicology (VBSC 5102, OSU), currently co-instructor. Lecturer in Veterinary (Pharmacodynamics, Autonomic Drugs) Pharmacology (VMED 7333, OSU; 2007-present) and Cell and Molecular Biology (VBSC 5013; 2010-present). IOR for Experimental Principles and Approaches (ITOX 5802) and Toxicology of Chemical Warfare (ITOX 5902).

9 7/89 to 12/99. Lecturer in undergraduate and graduate Pharmacology and Toxicology courses. Instructor-in-charge for Toxicology and the Environment (Toxi 101, ULM), General Laboratory Techniques (Toxi 401, ULM), Pesticide Toxicology (Phar 467, ULM), Biochemical Toxicology (Phar 550, ULM), Advanced Toxicology Laboratory (Phar 582, ULM), Principles and Methods of Toxicology (Phar 590, ULM), Neuropharmacology (Phar 583, ULM).

7/86-6/89 Participated in the training of students and technicians at the Health Effects Research Laboratory (U.S. EPA) in methods of biochemical toxicology. Included animal dosing, enzyme assays, extraction and separation of lipids, HPLC, protein purification, liquid chromatography, brain and peripheral dissections and polyacrylamide gel electrophoresis.

Spring, 1983 Lecturer, University of Houston-Clear Lake, TX. Instructor for graduate pharmacology class.

ASSOCIATIONS MEMBER, Society of Toxicology, International Neurotoxicology Association, International Society for Neurochemistry, Society for Toxicology and Environmental Chemistry. PAST-PRESIDENT, International Neurotoxicology Association (2005-2007). PAST-PRESIDENT (1998-1999) South Central Chapter/Society of Toxicology. PAST-PRESIDENT, Neurotoxicology Section, Society of Toxicology (2005-2006). FACULTY ADVISOR, (1992-1996), NLU Pharmacy Graduate Students Association, (1989- 1993), Tau Omicron Chi Toxicology Students Organization

PEER-REVIEWED PUBLICATIONS (Google Scholar 5,311 citations, H index=36 [May, 2019])

1. Hester K, Bhattari K, Jiang H, Agarwal P, Pope, C. (2019). Engineering dynamic surface peptide networks on butyrylcholinesteraseG117H for enhanced organophosphate catalysis. Chem Res Toxicol. 10.1021/acs.chemrestox.9b00146.

2. Anderson T, Liu J, McMurry S, Pope C. (2018). Comparative in vitro and in vivo effects of chlorpyrifos oxon in the outbred mouse (Mus musculus) and Great Plains toad (Anaxyrus cognatus). Environ Toxicol Chem. 37: 1898-1906.

3. Pope CN, Brimijoin S. (2018). Cholinesterases and the fine line between poison and remedy. Biochem Pharmacol. 153:205-216. (Invited review in 60th Jubilee edition)

4. Hester K, Liu J, Flynn N, Sultatos LG, Geng L, Brimijoin S, Ramsey JD, Hartson S, Ranjan A, Pope C. (2017). Polyionic complexes of butyrylcholinesterase and poly-l- lysine-g-poly(ethylene glycol): Comparative kinetics of catalysis and inhibition and in vitro inactivation by proteases and heat. Chem Biol Interact. 275: 86-94.

5. Bahrami M, Laurienti PJ, Quandt SA, Talton J, Pope CN, Summers P, Burdette JH, Chen H, Liu J, Howard TD, Arcury TA, Simpson SL. (2017). The Impacts of Pesticide and Nicotine Exposures on Latino Farmworkers’ Functional Brain Networks. NeuroToxicology 62: 138-150.

6. Sahoo K, Karumuri S, Hikkaduwa Koralege R, Flynn N, Hartson S, Liu J, Ramsey J, Kalkan K, Pope C, Ranjan A. (2017). Molecular and biocompatibility characterization of red blood cell membrane targeted and cell penetrating peptide-modified polymeric nanoparticles. Mol. Pharmaceut. 14: 2224-2235.

7. Bhawadraj M, Katz SD, Pope CN and Maxwell LK. (2017). Subacute pyridostigmine exposure increases heart rate recovery and cardiac parasympathetic tone in rats. Clin Exper Pharmacol Physiol 44: 872-879.

8. Laurienti, PJ, Burdette, JH, Talton, J, Pope, CN, Summers, P, Walker, F, Quandt, SA, Lyday, RG, Chen, H., Howard, TD, Arcury, TA. (2016). Brain anatomy in Latino farmworkers exposed to pesticides and nicotine. J Occup. Environ. Med. 58: 436-443.

9. Flynn NH, Topal ÇÖ, Hikkaduwa Koralege RS, Hartson S, Ranjan A, Liu J, Pope C, Ramsey JD (2016). Effect of Cationic Grafted Copolymer Structure on the Encapsulation of Bovine Serum Albumin. Materials Science and Engineering C 62: 524-531.

10. K. Sahoo, R.S. Hikkaduwa Koralage, N. Flynn, S. Koteeswara, P. Clark, S. Hartson, J. Liu, J.D. Ramsey, C. Pope, A. Ranjan (2016). Nanoparticle targeting to erythrocyte via the glycophorin A affinity ligand, ERY1 enhances binding without impacting cellular function. Pharm. Res. 33: 1191-1203.

11. Pope C, Uchea C, Flynn N, Poindexter K, Geng L, Brimijoin WS, Hartson S, Ranjan A, Ramsey JD, Liu J (2015). In vitro Characterization of Cationic Copolymer-Complexed Recombinant Human Butyrylcholinesterase. Biochem Pharmacol 98: 531-539.

12. Liu J, Parsons LH, Pope CN. (2015). Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum. NeuroToxicology 50:20-27.

13. Quandt, S.A., Pope, C.N., Chen, H., Summers, P. and Arcury, T.A. (2015). Longitudinal assessment of blood cholinesterase activities over two consecutive years among Latino non-farmworkers and pesticide-exposed farmworkers in North Carolina. J Occup Environ Med. 57:851-7.

14. Liu, J., Pope, C. (2015). The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. NeuroToxicology 46: 12-18.

11 15. Liu, J., Parsons, L., Pope, C.N. (2013). Comparative effects of parathion and chlorpyrifos on hippocampal extracellular endocannabinoid levels: influence on cholinergic toxicity. Toxicol. Appl. Pharmacol. 272: 608-615.

16. Qualls, H., Holbrook, T., Gilliam, L., Njaa, B., Panciera, R., Pope, C., Payton, M. (2013). Evaluation of three gastrointestinal protectants in an animal model of equine cantharidin toxicosis. J. Vet. Intern. Med. 27: 1179-1184.

17. Baireddy, P., Liu, J., Pope, CN. (2011). Comparative effects of chlorpyrifos on cholinergic toxicity and acetylcholine release in wild type and CB1 receptor knockout mice. Toxicol. Appl. Pharmacol. 256: 324-329.

18. Yu, L., Scherlag, B.J., Dormer, K., Nguyen, K.T., Pope, C., Fung, K-M., Po, S.S. (2010). Autonomic denervation using magnetic nanoparticles. Circulation 122: 2653-2659.

19. Ray, A., Liu, J., Ayoubi, P. and Pope, C. (2010). Dose-related changes in gene expression in forebrain following acute low-level chlorpyrifos exposure in neonatal rats. Toxicol. Appl. Pharmacol. 248: 144-155.

20. Wright, L.K.M., Liu, J., Nallapaneni, A. and Pope, C. (2010). Persistent behavioral sequelae following acute diisopropylfluorophosphate intoxication in rats: comparative effects of atropine and the fatty acid amide hydrolase inhibitor URB597. Neurotoxicol. Teratol. 32: 329-335.

21. Pope, C.N., Mechoulam, R. and Parsons, L. (2010). Endocannabinoid signaling in neurotoxicity and neuroprotection. NeuroToxicology 31: 562-571.

22. Duarte, T., Houze, P., Risede, P., Pope, C., Scherrmann, J.-M., and Baud, F. (2010). Dose-dependent effects on ventilation at rest induced by high doses of cannabinoids in rats. Acta Clinica Belgica 65 (S1): 90-99.

23. Jiang, H., Liu, S., Zhao, P., and Pope, C. (2009). Recombinant expression and biochemical characterization of the catalytic domain of acetylcholinesteraes-1 from the African malaria mosquito, Anopheles gambiae. Insect Biochem. Mol. Biol. 39: 646-653.

24. Ray, A., Liu, J., Karanth, S. Gao, Y., Brimijoin, W and Pope, C. (2009). Cholinesterase inhibition and acetylcholine accumulation following intracerebral administration of paraoxon in rats. Toxicol. Appl. Pharmacol. 236: 341-347.

25. Nallapaneni, A., Liu, J., Karanth, S. and Pope, C. (2008). Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorphosphate. NeuroToxicology 29: 1037-1043.

26. Zhang, Y., Chen, W. Wang, S., Liu, Y. and Pope, C. (2008). Phototoxicity of zinc oxide nanoparticle conjugates in human ovarian cancer NIH: OVCAR-3 cells. J. Biomed. Nanotechnol. 4: 432–438.

27. Mirajkar, N. and Pope, C. (2008). In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding to organophosphorus anticholinesterases in heart and brain of adult and aging rats. Biochem. Pharmacol. 76: 1047-1058.

28. Zamora, E.M.U., Liu, J. And Pope, C. (2008). Effects of chlorpyrifos oxon on muscarinic M2 receptor internalization in different cell types. J. Toxicol. Environ. Health A 71: 1440-1447.

29. Karanth, S., Holbrook, T., MacAllister, C. and Pope, C. (2008). Selective inhibition of butyrylcholinesterase in vivo in horses by the feed through larvacide Equitrol®. Reg. Toxicol. Pharmacol. 50: 200-205.

30. Karanth, S., Liu, J., Ray, A. and Pope, C. (2007). Comparative in vivo effects of parathion on striatal acetylcholine accumulation in adult and aged rats. Toxicology 239: 167-179.

31. Howard, M., Mirajkar, N., Karanth, S. and Pope, C. (2007). Comparative effects of oral chlorpyrifos exposure on cholinesterase activity and muscarinic receptor binding in neonatal and adult heart. Toxicology 238: 157-165.

32. Liu, J., Gupta, R., Goad, J.T., Karanth, S. and Pope, C. (2007). Modulation of parathion toxicity by glucose feeding: is nitric oxide involved? Toxicol. Appl. Pharmacol. 219: 106- 113.

33. Baireddy, P., Mirajkar, N., Nallapaneni, A., Singleton, N. and Pope, C. (2007). Effects of combined, multiple stressors on acute pyridostigmine toxicity in rats. Arch. Toxicol. 81: 283-289.

34. Zhang, Y., Chen, W., Zhang, J., Liu, J., Chen, G., and Pope, C. (2007). In vitro and in vivo toxicity of CdTe nanoparticles. J. Nanosci. Nanotechnol. 7: 497-503.

35. Nallapaneni, A., Liu, J., Karanth, S., and Pope, C. (2006). Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2. Toxicology 227: 173-183.

36. Liu, Y., Chen, W., Joly, A.G., Wang, Y., Pope, C., Zhang, Y., Bovin, J-O, and Sherwood, P. (2006). Comparison of CdTe nanoparticles synthesized in air and in nitrogen. J. Phys. Chem. B 110: 16992-17000.

37. Karanth, S., Liu, J., Mirajkar, N. and Pope, C. (2006). Effects of acute chlorpyrifos exposure on in vivo striatal acetylcholine accumulation in rats. Toxicol. Appl. Pharmacol. 216: 150-156.

13 38. Kacham, R., Karanth, S., and Pope, C. (2006). Interactive toxicity of chlorpyrifos and parathion in neonatal rats: role of esterases in exposure sequence-dependent toxicity. Toxicol. Appl. Pharmacol. 210:142-149.

39. Zou, L. and Pope, C. (2005). Effects of organophosphorus insecticides on G-protein coupled receptor kinase 2-mediated phosphorylation of m2 muscarinic receptors. Chin. J. Pub. Health 21: 1326-1328.

40. Pope, C., Karanth, S. and Liu, J. (2005). Comparative carboxylesterase activities in infant and adult liver and their in vitro sensitivity to chlorpyrifos oxon. Regul. Toxicol. Pharmacol. 42: 64-69.

41. Pope, C., Karanth, S., Liu, J. and Yan, B. (2005). Comparative carboxylesterase activities in infant and adult liver and their in vitro sensitivity to chlorpyrifos oxon. Regul Toxicol Pharmacol. 42: 64-69.

42. Liu, J., Karanth, S. and Pope, C. (2005). Effects of excess sugar consumption on parathion toxicity in juvenile and adult rats. Toxicology 210: 135-145.

43. Pope, C., Karanth, J. and Liu, J. (2005). Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action. Environ. Toxicol. Pharmacol. 19: 433-446.

44. Maiti, S., Grant, S., Baker, S.M., Karanth, S., Pope, C.N. and Chen, G. (2004). Stress regulation of sulfotransferases in male rat liver. Biochem. Biophys. Res. Comm. 323: 235- 241.

45. Song, X., Pope, C., Murthy, R., Shaikh, J., Lal, B. and Bressler, J.P. (2004). Interactive effects of paraoxon and pyridostigmine on blood-brain barrier integrity and cholinergic toxicity. Toxicol. Sci. 78: 241-247.

46. Karanth, S. and Pope, C.N. (2004). Interactive toxicity of the organophosphorus insecticides chlorpyrifos and methyl parathion in adult rats. Toxicol. Appl. Pharmacol. 196: 183-190.

47. Karanth, S. and Pope, C.N. (2003). In vitro inhibition of blood cholinesterase activities from horse, cow and rat by tetrachlorvinphos. Int. J. Toxicol. 22: 429-433.

48. Shaikh, J. Karanth, S., Chakraborti, D., Pruett, S. and Pope, C.N. (2003). Effects of daily stress or repeated paraoxon exposures on subacute pyridstigmine toxicity in rats. Arch. Toxicol. 77: 576-583.

49. Shaikh, J. and Pope, C.N. (2003). Combined forced running stress and subclinical paraoxon exposure have little influence on pyridostigmine-induced acute toxicity in rats. Toxicology 190: 221-230.

50. Karanth, S. and Pope, C.N. (2003). Age-related effects of chlorpyrifos and parathion on acetylcholine release in rat striatum. Neurotox. Teratol. 25: 599-606.

51. Wu, Y.-J., Harp, P., Yan, X-R and Pope, C.N. (2003). Nicotinic autoreceptor function in rat brain during maturation and aging: possible differential sensitivity to organophosphorus anticholinesterases. Chem.-Biol. Interactions 142: 255-268.

52. Song, X., Tian, H., Bressler, J., Pruett, S. and Pope, C.N. (2002). Acute and repeated restraint stress have little effect on pyridostigmine toxicity or brain regional cholinesterase inhibition in rats. Toxicological Sci. 69: 157-164.

53. Baer, K.N., Olivier, K. and C.N. Pope. (2002). Influence of temperature and dissolved oxygen on the acute toxicity of profenofos to fathead minnows (Pimephales promelas). Drug Chem. Toxicol. 25: 231-245.

54. Tian, H., Song, X., Bressler, J., Pruett, S. and Pope, C. (2002). Neither forced running nor forced swimming affect acute pyridostigmine toxicity or brain-regional cholinesterase inhibition in rats. Toxicology 176 (1-2): 39-50.

55. Zhang, H.S., Liu, J. and Pope, C.N. (2002). Age-related effects of chlorpyrifos on muscarinic receptor-mediated signaling in rat cortex. Arch. Toxicol. 75:676-684.

56. Liu, J., Chakraborti, T.K. and Pope, C.N. (2002). In vitro effects of organophosphorus anticholinesterases on muscarinic receptor-mediated inhibition of acetylcholine release in rat striatum. Toxicol. Appl. Pharmacol. 178:102-108.

57. Howard, M.D. and Pope, C.N. (2002). In vitro effects of chlorpyrifos, parathion, methyl parathion and their oxons on cardiac muscarinic receptor binding in neonatal and adult rats. Toxicology 170:1-10.

58. Karanth, S., Olivier, K., Jr., Liu, J. and Pope, C. (2001). In vivo interaction between chlorpyrifos and parathion in adult rats: sequence of administration can markedly influence toxic outcome. Toxicol. Appl. Pharmacol. 177: 247-255.

59. Olivier, K., Liu, J. and Pope, C.N. (2001). Inhibition of forskolin-stimulated cAMP formation in vitro by paraoxon and chlorpyrifos oxon in cortical slices from neonatal, juvenile and adult rats. J. Biochem. Mol. Toxicol. 15:263-269.

60. Olivier, K., J. Liu, S. Karanth, H. Zhang, D.S. Roane and C. Pope. (2001). Glucose feeding exacerbates parathion-induced neurotoxicity. J. Toxicol. Environ. Health 63:253- 271.

61. Won, Y.K., Zheng, Q., Olivier, K. Jr., Liu, J. and Pope, C.N. (2001). Age-related effects of chlorpyrifos on acetylcholine release in rat brain. NeuroToxicology 22:37-46.

15 62. Karanth, S. and Pope, C. (2000). Carboxylesterase and A-esterase activities during maturation and aging: relationship to the toxicity of chlorpyrifos and parathion in rats. Toxicological Sci. 58:282-289.

63. Zheng, Q., Won, Y., Olivier, K. and Pope, C. (2000). Comparative cholinergic neurotoxicity of oral chlorpyrifos exposures in preweanling and adult rats. Toxicological Sci. 55:124-132.

64. Liu, J., Olivier, K. and Pope, C.N. (1999). Comparative neurochemical effects of repeated methyl parathion or chlorpyrifos exposures in neonatal and adult rats. Toxicol. Appl. Pharmacol. 158:186-196.

65. Pope, C.N. (1999). Organophosphorus pesticides: do they all have the same mechanism of toxicity. J. Toxicol. Environ. Health Part B 2:101-121.

66. Mileson, B.M., Chambers, J., Chen, B., Dettbarn, W., Ehrich, M., Eldefrawi, A., Gaylor, D., Hamernik, K., Hodgson, E., Karczmar, A., Padilla, S., Pope, C., Richardson, R., Saunders, D., Sheets, L., Sultatos, L. and Wallace, K. (1998). Common mechanism of toxicity: A case study of organophosphorus pesticides. Toxicological Sci. 41:8-20.

67. Liu, J. and Pope, C.N. (1998). Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathion. J. Toxicol. Environ. Health 53:101-114.

68. Pope, C.N. and Liu, J. (1997). Age-related differences in sensitivity to organophosphorus pesticides. Environ. Toxicol. Pharmacol. 4:309-314.

69. Harp, P., Jr., Tanaka, D. Jr. and Pope, C.N. (1997). Potentiation of organophosphorus- induced delayed neurotoxicity following phenyl saligenin phosphate exposures in 2-, 5-, and 8-week-old chickens. Fund. Appl. Toxicol. 37:64-70.

70. Liu, J. and Pope, C.N. (1996). Effects of chlorpyrifos on high-affinity choline uptake and [3H]hemicholinium-3 binding in rat brain. Fund. Appl. Toxicol. 34:84-90.

71. Chanda, S.M. and Pope, C.N. (1996). Neurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats. Pharmacol. Biochem. Behav. 53:771-776.

72. Chanda, S.M., P. Harp, J. Liu, and C.N. Pope. (1995). Comparative developmental and maternal neurotoxicity following acute gestational chlorpyrifos exposure in rats. J. Toxicol. Environ. Health 44:189-202.

73. Pope, C., K. diLorenzo, and M. Ehrich. (1995). Possible involvement of a neurotrophic factor during the early stages of organophosphate-induced delayed neurotoxicity. Toxicol. Lett. 75:111-117.

74. Tandon, P., S. Padilla, S. Barone, Jr., C.N. Pope and H.A. Tilson. (1994). Fenthion produces persistent decreases in muscarinic receptor function in the adult rat retina. Toxicol. Appl. Pharmacol. 125:271-280.

75. Rao, P.S., G.H. Roberts, C.N. Pope and P.W. Ferguson. (1994). Comparative inhibition of rodent and human erythrocyte acetylcholinesterase by carbofuran and carbaryl. Pest. Biochem. Physiol. 48:79-84.

76. Chaudhuri, J., S. Chanda, T.K. Chakraborti and C.N. Pope. (1993). Differential modulation of organophosphate-sensitive muscarinic receptors in rat brain by parathion and chlorpyrifos. J. Biochem. Toxicol. 8:207-216.

77. Chakraborti, T.K., J.D. Farrar and C.N. Pope. (1993). Comparative neurochemical and neurobehavioral effects of repeated chlorpyrifos exposures in young and adult rats. Pharmacol. Biochem. Behav. 46:219-224.

78. Pope, C.N., D. Tanaka, Jr. and S. Padilla. (1993). The role of neurotoxic esterase in the prevention and potentiation of organophosphorus-induced delayed neurotoxicity. Chemico-Biol. Interact. 87:395-406.

79. Bushnell, P.J., C.N. Pope and S. Padilla. (1993). Behavioral and neurochemical effects of acute chlorpyrifos in rats: tolerance to prolonged inhibition of cholinesterase. J. Pharmacol. Exp. Ther. 266:1007-1017.

80. Tandon, P., C. Pope, S. Padilla, H.A. Tilson, and G.J. Harry. (1993). Developmental changes in carbachol-stimulated inositol phosphate release in pigmented rat retina. Curr. Eye Res. 12:439-449.

81. Padilla, S., D.L. Lyerly and C.N. Pope. (1992). Subacute ethanol consumption reverses p- xylene-induced decreases in axonal transport. Toxicology 75:159-167.

82. Padilla, S., V.C. Moser, C.N. Pope and W.S. Brimijoin. (1992). Paraoxon toxicity is not potentiated by prior reduction in blood acetylcholinesterase. Toxicol. Appl. Pharmacol. 117:110-115.

83. Pope, C.N. and T.K. Chakraborti. (1992). Dose-related inhibition of brain and plasma cholinesterase in neonatal and adult rats following sublethal organophosphate exposures. Toxicology 73:35-43.

84. Pope, C.N., T.K. Chakraborti, M.L. Chapman and J.D. Farrar. (1992). Longterm neurochemical and behavioral effects induced by acute chlorpyrifos treatment. Pharmacol. Biochem. Behav. 42:251-256.

17 85. Pope, C.N., M.L. Chapman, D. Tanaka, Jr., and S. Padilla. (1992). Phenylmethylsulfonyl fluoride alters sensitivity to organophosphorus-induced delayed neurotoxicity in developing animals. Neurotoxicology 13:355-364.

86. Pope, C.N., T.K. Chakraborti, M.L. Chapman, J.D. Farrar and D. Arthun. (1991). Comparison of in vivo cholinesterase inhibition in neonatal and adult rats by three organophosphorothioate insecticides. Toxicology 68:51-61.

87. Padilla, S. and C.N. Pope. (1991). Retrograde axonal transport of locally synthesized phosphoinositides in the rat sciatic nerve. J. Neurochem. 57:415-422.

88. Bushnell, P.J., S.S. Padilla, T. Ward, C.N. Pope and V.B. Olszyk. (1991). Behavioral and neurochemical changes in rats dosed repeatedly with diisopropylfluorophosphate (DFP). J. Pharmacol. Exp. Ther. 256:741-750.

89. Veronesi, B., S. Padilla, K. Blackmon and C. Pope. (1991). Murine susceptibility to organophosphorus-induced delayed neuropathy (OPIDN). Toxicol. Appl. Pharmacol. 107:311-324.

90. Veronesi, B. and C. Pope. (1990). The neurotoxicity of parathion-induced acetylcholinesterase depression in neonatal rats. Neurotoxicology 11:465-482.

91. Pope, C.N. and S. Padilla. (1990). Potentiation of organophosphorus-induced delayed neurotoxicity by phenylmethylsulfonyl fluoride. J. Toxicol. Environ. Health 31:261-273.

92. Veronesi, B., K. Jones, and C. Pope. (1990). The neurotoxicity of subchronic acetylcholinesterase (AChE) inhibition in rat hippocampus. Toxicol. Appl. Pharmacol. 104:440-456.

93. Pope, C.N. and S. Padilla. (1989). Modulation of neurotoxic esterase activity in vitro by phospholipids. Toxicol. Appl. Pharmacol. 97, 272-278.

94. Pope, C.N. and S. Padilla. (1989). Chromatographic characterization of neurotoxic esterase. Biochem. Pharmacol. 38:181-188.

95. Pope, C.N., B.T. Ho and A.A. Wright. (1987). Neurochemical and behavioral effects of N-ethyl acetylcholine aziridinium chloride in mice. Pharmacol. Biochem. Behav. 26:365- 371.

96. Pope, C.N., L.F. Englert and B.T. Ho. (1985). Passive avoidance deficits in mice following ethylcholine aziridinium chloride treatment. Pharmacol. Biochem. Behav. 22:297-299.

18 97. Pope, C.N. (1985). Studies on cholinergic function and memory in mice. Doctoral dissertation, University of Texas Graduate School of Biochemical Sciences, Houston, TX.

19 BOOKS

C.N. Pope, J. Liu, eds, (projected 2019). An Introduction to Interdisciplinary Toxicology: From Molecules to Man, Elsevier, Oxford, UK. This is an ongoing book project based on framework of our ITOX 6213 course (expected publication date, 2019).

Carlson, G.P., Bailer, A.J., Borak, J., Chambers, J.E., Ehrich, M., Haber, L., Leffingwell, S.S., Moore, D.H., Pope, C., Spencer, P.S. and Tran, N.L. (2005). Review of the Department of Defense Research Program on Low-level Exposures to Chemical Warfare Agents. National Academies Press, Washington, DC, 103 pp.

BOOK CHAPTERS

1. Pope Carey N, Edrophonium, Reference Module in Biomedical Sciences. Elsevier. 28- Oct-2017 doi:10.1016/B978-0-12-801238-3.97625-6

2. Anderson T., Pope C. Pyridostigmine, Reference Module in Biomedical Sciences. Elsevier. 28-Oct-2017 doi:10.1016/B978-0-12-801238-3.97627-X

3. Poindexter K, Pope C. Tabun. Reference Module in Biomedical Sciences. Elsevier. 15- Jul-2017 doi:10.1016/B978-0-12-801238-3.97320-3

4. Liu, J., Uchea, C., Wright, L., and Pope, C. (2015). Chemical warfare agents and the nervous system. Handbook of Toxicology and Chemical Warfare Agents, 2nd edition (R. Gupta, ed), pp. 463-475.

5. Pope, C., (2014). Malonitrile. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 3. Elsevier Inc., Academic Press, pp. 142–143.

6. Pope, C. (2014). Butyronitrile. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 1. Elsevier Inc., Academic Press, pp. 602–603.

7. Pope, C. (2014). Parathion. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 3. Elsevier Inc., Academic Press, pp. 759–761.

8. Pope, C. (2014). Pesticides. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 3. Elsevier Inc., Academic Press, pp. 826–827.

9. Pope, C. (2014). Mirex. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 3. Elsevier Inc., Academic Press, pp. 345–346.

10. Pope, C. (2014). Methyl Parathion. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 3. Elsevier Inc., Academic Press, pp. 324–326.

20 11. Pope, C. (2014). Chemical Interactions. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 1. Elsevier Inc., Academic Press, pp. 793–794.

12. Pope, C. (2009). General texts. Pages 59-65 in Information Resources in Toxicology, 4th edition (P. Wexler, S.G. Gilbert, P.J. Hakkinen, and A. Mohapatra, eds), Academic Press, San Diego, CA, USA.

13. Wright, L., Pope, C. and Liu, J. (2008). The nervous system as a target for chemical warfare agents. Pages 463-480 in Handbook of Toxicology of Chemical Warfare Agents (R.C. Gupta, ed), Academic Press, San Diego, CA, USA.

14. Pope, C.N. (2006). CNS effects and neurotoxicity. Pages 271-291 in Toxicology of Organophosphate and Carbamate Compounds (R.C. Gupta, ed), Elsevier, Oxford, UK.

15. Pope, C.N. (2005). Chemical interactions. Pages 515-516 in Encyclopedia of Toxicology, vol.1, 2nd edition (P. Wexler, ed), Elsevier, Oxford, UK.

16. Pope, C.N. (2005). Butyronitrile. Pages 370-371 in Encyclopedia of Toxicology, vol. 1, 2nd edition (P. Wexler, ed), Elsevier, Oxford, UK.

17. Pope, C.N. (2005). Methomyl. Pages 57-58 in Encyclopedia of Toxicology, vol. 3, 2nd edition (P. Wexler, ed), Elsevier, Oxford, UK.

18. Pope, C.N. (2005). Pesticides. Pages 371-372 in Encyclopedia of Toxicology, 2nd edition (P. Wexler, ed), Elsevier, Oxford, UK.

19. Mirajkar, N. and Pope, C.N. (2005). Dimethoate. Pages 47-49 in Encyclopedia of Toxicology, vol. 2, 2nd edition (P. Wexler, ed), Elsevier, Oxford, UK.

20. Mirajkar, N. and Pope, C.N. (2005). Dichlorvos. Pages 13-15 in Encyclopedia of Toxicology, vol. 2, 2nd edition (P. Wexler, ed), Elsevier, Oxford, UK.

21. Nallapaneni, A. and Pope, C.N. (2005). Chlorpyrifos. Pages 583-585 in Encyclopedia of Toxicology, vol. 1, 2nd edition, Elsevier, Oxford, UK (in press).

22. Pope, C.N. and Liu, J. (2004). Non-cholinesterase actions of anticholinesterases. Pages 215-239 in Pharmacological Perspectives of Toxic Chemicals and Their Antidotes, (S.J.S. Flora, J.A. Romano, S.I. Baskin, K. Sekhar, eds), Narosa Publishing Co, New Delhi, India.

23. Pope, C.N. and Liu, J. (2002). Non-esterase actions of anticholinesterase insecticides. Pages 29-43 in Neurotoxicology Handbook, Volume 1, Humana Press, Totawa, NJ.

21 24. Pope, C.N. (2001). Influence of age on pesticide toxicity. Pages 873-885 in Handbook of Pesticide Toxicology, 2nd Edition (R. Krieger, J. Doull, D. Ecobichon, E. Hodgson, L. Reiter, J. Ross, J. Seiber and D. Gammon, eds). Academic Press, San Diego, CA.

25. Pope, C.N. (1998). Chlorpyrifos. Pages 322-324 in Encyclopedia of Toxicology Volume 1 (P. Wexler, ed), Academic Press, San Diego, CA.

26. Pope, C.N. (1998). Dichlorvos. Pages 468-469 in Encyclopedia of Toxicology Volume 1 (P. Wexler, ed), Academic Press, San Diego, CA.

27. Pope, C.N. (1998). Dimethoate. Pages 482-483 in Encyclopedia of Toxicology Volume 1 (P. Wexler, ed), Academic Press, San Diego, CA.

28. Pope, C.N. and Reeves, J. (1998). Fenvalerate. Pages 5-6 in Encyclopedia of Toxicology Volume 2 (P. Wexler, ed), Academic Press, San Diego, CA.

29. Reeves, J. and Pope, C.N. (1998). Methomyl. Pages 298-299 in Encyclopedia of Toxicology Volume 2 (P. Wexler, ed), Academic Press, San Diego, CA.

30. Pope, C.N. (1998). Methyl Parathion. Pages 318-319 in Encyclopedia of Toxicology Volume 2 (P. Wexler, ed), Academic Press, San Diego, CA.

31. Pope, C.N. (1998). Pesticides. Pages 494-495 in Encyclopedia of Toxicology Volume 2 (P. Wexler, ed), Academic Press, San Diego, CA.

32. Reeves, J. and Pope, C.N. (1998). Rotenone. Pages 114-115 in Encyclopedia of Toxicology Volume 3 (P. Wexler, ed), Academic Press, San Diego, CA.

33. Reeves, J. and Pope, C.N. (1998). Thiram. Pages 234-235 in Encyclopedia of Toxicology Volume 3 (P. Wexler, ed), Academic Press, San Diego, CA.

34. Feldhaus, J.M., Feldhaus, A.J., Ace, L.N. and Pope, C.N. (1998). Interactive effects of pesticide mixtures on the neurobehavioral responses and AChE levels of planaria. Pages 140-150 in Environmental Toxicology and Risk Assessment: Seventh Volume (E.E. Little, B.M. Greenberg and A.J. DeLonay, eds), ASTM, West Conshohocken, PA.

35. Pope, C.N., J. Chaudhuri and T.K. Chakraborti. (1995). Organophosphate-sensitive cholinergic receptors: possible role in modulation of anticholinesterase-induced toxicity. Pages 305-312 in Enzymes of the Cholinesterase Family (A.S. Balasubramanian, B.P. Doctor, P. Taylor and D.M. Quinn, eds), Plenum, New York.

PROFESSIONAL/EDUCATIONAL PUBLICATIONS

1. Griswold, P., Pope, C.N. and Ferguson, P.W. (1991). Laboratory Manual for General Toxicology. Northeast Louisiana University.

2. Ferguson, P.W., Bourn, W.M., Pope, C.N. and Roberts, B.L. (1991). A bachelor of science toxicology program: description, resources, student profiles and graduate placement. Am. J. Pharmaceut. Educ. 55:243-247.

3. Ferguson, P.W. and Pope, C.N. (1992). Poison prevention. Louisiana Pharmacist March/April: 17-19.

4. Pope, C.N. (1995). Since Alar: Age-related differences in sensitivity to pesticides. Res Scholaris 1:22-25. PUBLISHED ABSTRACTS

1. Poindexter K, Liu J, Flynn N, Ramsey, Hartson S, Ranjan A, Brimijoin S, Pope C. Comparative kinetics of inhibition, proteolytic sensitivity and heat inactivation of free and nanocomplexed butyrylcholinesterase. The Toxicologist, Annual Meeting of Society of Toxicology, 2017.

2. Hester K, Pope, Agarwal P, Pope CN. ButyrylcholinesteraseG117H as a catalytic bioscavenger: structure:dynamics:activity relationships. The Toxicologist, Annual Meeting of the Society of Toxicology, 2018.

3. Hester K, McClay K, Pope CN. Butyrylcholinesterase inhibition and ghrelin-induced mediated food intake in rats. The Toxicologist, Annual meeting of Society of Toxicology, 2019.

4. Anderson, T., Liu, J., McMurry, S. and Pope, C. Comparative in vitro Sensitivity of Amphibian and Mammalian Acetylcholinesterase to Inhibition by Organophosphorus Inhibitors. Society for Environmental Chemistry and Toxicology World Congress, November 9, 2016, Orlando, FL.

5. Poindexter K., Liu J., Sultatos L., Flynn N, Ramsey J, Hartson S, Ranjan A, and Pope C. Substrate and Inhibitor Kinetics of Free and Copolymer-Complexed Recombinant Human Butyrylcholinesterase. 55th Society of Toxicology annual meeting, March 15, 2016, New Orleans, LA.

6. Anderson T., Liu J., McMurry S., Pope C. Comparative Sensitivity of Amphibian and Mammalian Acetylcholinesterase to Inhibition by Paraoxon. Ozark Prairie Regional SETAC Chapter Conference, May 17, 2016, Decatur, IL.

7. Pope, C., Brimijoin, W.S., Flynn, N., Hartson, S., Li, Y., Hidukka Koralege, R., Poindexter, K., Ramsey, J., Ranjan, A., Sahoo, K., Uchea, C., Liu, J. Erythrocytes as targeted carriers for nanoencapsulated butyrylcholinesterase. 12th Cholinesterase Meeting, Elche, Spain. September 27, 2015.

23 8. Liu, J. and Pope, C. Dose- and time-related effects of diisopropylfluorophosphate (DFP) on depressive-like behaviors in rats. J. Liu and C. Pope. 14th International Neurotoxicology Association Meeting, Egmond aan Zee, The Netherlands. June 9-14, 2013.

9. Pope, C., Parsons L., and Liu J. Comparative effects of parathion and chlorpyrifos on extraceullar endocannabinoids. 14th International Neurotoxicology Association Meeting, Egmond aan Zee, The Netherlands. June 9-14, 2013.

10. Liu, J. and Pope, C. Pharmacological modulation of endocannabinoid signaling differentially affects acute toxicity of paraoxon and chlorpyrifos oxon in rats. Society of Toxicology annual meeting, San Antonio, TX, March 12, 2013.

11. Pope, C., Liu, J. and Parsons, L. Comparative effects of parathion and chlorpyrifos on extracellular endocannabinoid levels: influence on cholinergic toxicity. Society of Toxicology annual meeting, San Antonio, TX, March 13, 2013.

12. Pope, C., Baireddy, P. and Liu, J. Effects of chlorpyrifos on cholinergic signs, cholinesterase and hippocampal acetylcholine release in wildtype and cannabinoid cb1 knockout mice. 13th International Neurotoxicology Association Meeting, Xi-An, PR China, June 5-10, 2011.

13. Liu, J., Wright, LKM, Pope, C. Acrylamide (ACR) and n-isopropylacrylamide (NIPA) increase acetylcholine release in rat striatal slices. 13th International Neurotoxicology Association Meeting, Xi-An, PR China, June 5-10, 2011.

14. Pope, C., Liu, J., Nallapaneni, A., Wright, L., and Parsons, L. (2009). Modulation of anticholinesterase toxicity by endocannabinoids. Proceedings, 12th Meeting of the International Neurotoxicology Association, Jerusalem, Israel.

15. Pope, C. (2008). The modulation of neurotoxicity by endocannabinoid signaling. Proceedings, 25th Annual International Neurotoxicology Conference, Rochester, NY.

16. Likins, A.M., Nallapaneni, A. and Pope, C.N. (2008). Comparative in vitro inhibition of rat hippocampal monoacylglycerol lipase by chlorpyrifos oxon, paraoxon and diisopropylfluorophosphate. Toxicologist 102: 283. Annual Meeting, Society of Toxicology, March 16-20, Seattle, WA.

17. Martin, C., Houze, P., Duarte, T., Pope, C., and Baud, F. (2008). Tissue cholinesterase activities do not explain rebound of paraoxon-induced respiratory toxicity after pralidoxime in rats. Toxicologist 102: 201. Annual Meeting, Society of Toxicology, March 16-20, Seattle, WA.

24 18. Houze, P., Pronzola, L., Kayouka, M., Pope, C. and Baud, F. (2008). Atropine but not methyl atropine corrects paraoxon-induced respiratory disturbances. Toxicologist 102: 201. Annual Meeting, Society of Toxicology, March 16-20, Seattle, WA.

19. Kayouka, M., Houze, P., Risede, P., Monier, C., Cisternino, S., Pope, C. and Baud, F. (2008). Organic cation transporters 1 and 2 mediate pralidoxime renal secretion. Toxicologist 102: 138. Annual Meeting, Society of Toxicology, March 16-20, Seattle, WA.

20. Nallapaneni, A., Liu, J. and Pope, C. (2007). Cannabinoid modulation of organophosphate toxicity. Proceedings, 17th Neuropharmacology Conference, November 1, 2007, San Diego, CA.

21. Pope, C. and Nallapaneni, A. (2007). Cannabinergic and cholinergic interactions in the expression of anticholinesterase toxicity. Proceedings, 11th International Neurotoxicology Association meeting, June 12, 2007, Monterey, CA.

22. Liu, J. and Pope, C. (2007). The nitric oxide synthase inhibitor 7-nitroindazole potentiates brain and diaphragm cholinesterase inhibition and cholinergic toxicity following parathion exposure in rats. Proceedings, 11th International Neurotoxicology Association meeting, June 12, 2007, Monterey, CA.

23. Pope, C., 2007. Aging and sensitivity to organophosphorus insecticides: toxicokinetic and toxicodynamic factors. Toxicologist 96: 442.

24. Karanth, S., Liu, J., Ray, A. and Pope, C. (2007). In vivo striatal acetylcholine accumulation in adult and aged rats following parathion exposure. Toxicologist 96: 182.

25. Liu, J., Pope, C., Karanth, S. and Gupta, RC. (2006). Parathion-induced changes in rat brain regional citrulline and high-energy phosphate levels are enhanced by sugar feeding. Toxicologist 90: 301.

26. Karanth, S., Liu, J., Mirajkar, N. Ray, A. and Pope, C. (2006). Effects of chlorpyrifos on cholinesterase activity and in vivo acetylcholine accumulation in striatum of adult rats. Toxicologist 90: 301.

27. Pope, C.N., Kacham, R., Liu, J., Karanth, S. (2005). Exposure sequence influences cholinergic toxicity in neonatal rats exposed to two organophosphorus insecticides. Page 24 in the proceedings of the 22nd International Neurotoxicology Conference, Environment and Neurodevelopmental Disorders, Research Triangle Park, NC.

28. Pope, C.N. and Liu, J. (2005). Neurotoxicants and chemical terrorism: subpopulation considerations. Proceedings of the 10th Meeting, International Neurotoxicology Association, p. 24.

25 29. Liu, J., Karanth, S. and Pope, C. (2005). Striatal acetylcholine accumulation following parathion exposure: modulation by dietary glucose. Proceedings of the 10th Meeting, International Neurotoxicology Association, p. 72.

30. Pope, C.N. (2005). Organophosphorus and carbamate cholinesterase inhibitors: Uses and misuses of a common mechanism. Toxicologist 84: 204.

31. Nallapaneni, A., Mirajkar, N., Karanth, S. and Pope, C.N. (2005). Modulation of cholinergic toxicity by cannabinoids. Toxicologist 84: 10-11.

32. Liu, J., Karanth, S. and Pope, C. (2004). Dietary sugar-induced modulation of parathion toxicity in juvenile and adult rats. Toxicologist 78: 279.

33. Pope, C., Karanth, S., Liu, J., Shaikh, J. and Yan, B. (2004). Human liver carboxylesterase during postnatal maturation and sensitivity to chlorpyrifos oxon. Toxicologist 78: 379.

34. Karanth, S., Mason, L., Holbrook, T., MacAllister, C. and Pope, C. (2004). In vivo and in vitro effects of the organophosphate insecticide tetrachlorvinphos on cholinesterase and carboxylesterase activities in horses. Toxicologist 78: 426.

35. Pope, C. (2003). Modulation of G-protein coupled receptor kinase 2-mediated phosphorylation of m2 muscarinic receptors in vitro by organophosphorus toxicants. 5th Congress of Toxicology in Developing Countries, Guilin, China, November, 2003.

36. Williamson, K.K., McKenzie, E.C., Pope, C.N. and Davis, M.S. Subclinical pyridostigmine intoxication causes airway hyperreactivity to histamine. Proc. Comp. Resp. Soc. 21:13, 2003.

37. Pope, C. (2003). Pharmacology and toxicology of cholinesterase inhibitors: from clinical practice to urban terror. 5th Congress of Toxicology in Developing Countries, Guilin, China, November, 2003.

38. Barton, H. and Pope, C. (2003). Cumulative risk assessment: getting from toxicology to quantitative analysis. Toxicologist 72: 6.

39. Song, X., Pope, C., Murthy, R., Shaikh, J. and Bressler, J. (2003). Pyridostigmine blocks paraoxon-induced blood brain barrier leakage. Toxicologist 72: 307.

40. Kacham, R., Karanth, S. and Pope, C. (2003). Interactive toxicity of chlorpyrifos and parathion in neonatal rats. Toxicologist 72: 308.

41. Karanth, S., Olivier, K. and Pope, C. (2002). Comparative toxicity of oral chlorpyrifos exposures in adult and aged rats. Toxicologist 66: 313.

26 42. Olivier, K. and Pope, C. (2002). Age and time-dependent effects of equitoxic dosages of parathion or chlorpyrifos on high affinity choline uptake in rat cortex and striatum. Toxicologist 66: 313.

43. Song, X., Tian, H., Bressler, J., Pruett, S. and Pope, C. (2002). Acute and repeated restraint stress have little influence on acute pyridostigmine toxicity. Toxicologist 66: 252.

44. Wu, Y-J., Yan, X-R and Pope, C.N. (2001). Nicotinic autoreceptor function in rat brain during maturation and aging: differential sensitivity to organophosphorus anticholinesterases. 3rd National Conference, Chinese Society of Toxicology, Nanjing, China, October, 2001.

45. Liu, J. and Pope, C. (2001). Nutritional influence on organophosphate toxicity. 3rd National Conference, Chinese Society of Toxicology, Nanjing, China, October, 2001.

46. Olivier, K. Jr., and Pope, C. (2001). Sequence of exposure to two organophosphorus insecticides markedly influences neurotoxic response in adult rats. 8th Meeting, International Neurotoxicology Association, Estoril, Portugal, June, 2001.

47. Liu, J., Yan, X. and Pope, C. (2001). Excess sugar intake and parathion toxicity. 8th Meeting, International Neurotoxicology Association, Estoril, Portugal, June, 2001.

48. Tian, H., Song, X. and Pope, C. (2001). Running and restraint stress fail to influence pyridostigmine-induced acetylcholinesterase inhibition in rat brain. Conference on Illnesses Among Gulf War Veterans: A Decade of Scientific Research, Alexandria, VA, January, 2001.

49. Karanth, S. and Pope, C. (2001). Age-related effects of chlorpyrifos and parathion on acetylcholine synthesis in rat brain. Toxicologist 60: 241.

50. Zhang, H.S. and Pope, C. (2001). Acetylcholinesterase inhibition, muscarinic receptor downregulation and phosphoinositide hydrolysis in neonatal, juvenile, and adult rat brain following chlorpyrifos or parathion exposure. Toxicologist 60: 241.

51. Olivier, K. and Pope, C. (2001). Age-related effects of chlorpyrifos on high affinity choline uptake in rat brain. Toxicologist 60: 241.

52. Liu, J., Wang, G. and Pope, C. (2001). Differential effects of organophosphates on acetylcholine release and muscarinic autoreceptors. Toxicologist 60: 242.

53. Howard, M. and Pope, C. (2001). In vitro effects of chlorpyrifos, methyl parathion, parathion and their oxons on cardiac muscarinic receptor binding. Toxicologist 60: 243.

27 54. Song, X., Tian, H. and Pope, C. (2001). Effects of restraint and treadmill running stress on pyridostigmine toxicity and acetylcholinesterase inhibition. Toxicologist 60: 246.

55. Liu, J., Olivier, K. Jr., Karanth, S., Zhang, H. and Pope, C. (2000). Glucose feeding exacerbates parathion-induced neurotoxicity. 21st Annual Meeting, American College of Toxicology, San Diego, CA, November, 2000.

56. Liu, J. and Pope, C. (2000). Age-related differences in sensitivity to the organophosphorus pesticide chlorpyrifos: influence of dosing regime. International Conference on Life Science and Clinical Medicine 2000, Beijing, China, April, 2000.

57. Olivier, K. and Pope, C. (2000). Age-related inhibition of forskolin stimulated cAMP formation by chlorpyrifos oxon in rat cortical slices. Toxicologist 54: 340.

58. Wu, Y.J. and Pope, C. (2000). Age-related expression of cortical nicotinic autoreceptor function: partial characterization and evaluation of sensitivity to organophosphorus pesticides. Toxicologist 54: 340.

59. Stiles, M.D.H. and Pope, C. (2000). In vitro and in vivo effects of chlorpyrifos on cardiac muscarinic receptors. Toxicologist 54: 341.

60. Stiles, M. and Pope, C. (1999). Acetylcholinesterase inhibition and [3H]oxotremorine binding in neonatal and adult rat heart following repeated oral chlorpyrifos exposures. Toxicologist 48: 100.

61. Olivier, K. Jr., Liu, J. and Pope, C. (1999). Comparative effects of paraoxon, chlorpyrifos oxon and muscarinic agonists on high affinity choline uptake in rat cortical and striatal synaptosomes. Toxicologist 48: 100.

62. Won, Y., Zheng, Q., Kiu, J. and Pope, C. (1999). Effects of oral chlorpyrifos on cortical and striatal muscarinic autoreceptor function in neonatal, juvenile and adult rats. Toxicologist 48: 101.

63. Harp, P. and Pope, C. (1999). Differential alterations in cortical nicotinic receptor- mediated acetylcholine release following in vivo and in vitro organophosphate exposure. Toxicologist 48: 101.

64. Zheng, Q., Olivier, K., Won, Y. and Pope, C. (1999). Comparative cholingeric neurotoxicity of oral chlorpyrifos exposures in neonatal and adult rats. Toxicologist 48: 186.

65. Liu, J., Olivier, K. Jr., and Pope, C. (1998). Comparative neurochemical changes in neonatal and adult rats following repeated chlorpyrifos or methyl parathion exposures. Toxicologist 42: 158.

28 66. Olivier, K., Jr., Liu, J., Harp, P., Bounds, J., Roane, D. and Pope, C. (1997). Modulation of parathion induced neurotoxicity by glucose feeding. Toxicologist 36: 18.

67. Liu, J. and Pope, C. (1996). Selective changes in presynaptic cholinergic processes following exposure to different organophosphate anticholinesterases. 27th Annual Meeting, American Society for Neurochemistry, Philadelphia, PA, March, 1996.

68. Chakraborti, T.K., Chaudhuri, J., Harp, P. and Pope, C. (1994). Comparative dose-related effects of parathion and chlorpyrifos on biochemical and functional endpoints. Toxicologist 14: 241.

69. Chaudhuri, J., Harp, P., Ang, C. and Pope, C. (1994). Parathion and chlorpyrifos differentially regulate muscarinic receptors in heart. Toxicologist 14: 244.

70. Tandon, P., Willig, S., Pope, C., Padilla, S. and Tilson, H.A. (1994). Dose-response study of the tissue-specific effects of fenthion on receptor function in rat CNS. Toxicologist 14: 257.

71. Harp, P., Chaudhuri, J., Chanda, S.M., Chakraborti, T. and Pope, C. (1994). Changes in sensitivity to the pesticide chlorpyrifos associated with early pregnancy. Toxicologist 14: 389.

72. Chanda, S.M., Harp, P., Liu, J. and Pope, C. (1994). Developmental neurotoxicity of acute and repeated chlorpyrifos exposures. Toxicologist 14: 392.

73. Tandon, P., Willig, S., Padilla, S., Pope, C.N., Barone, S. Jr., and Tilson, H.A. (1993). Prolonged effects of fenthion on retinal muscarinic receptor function in the adult rat. Toxicologist 13: 87.

74. Chanda, S.M., Chaudhuri, J., Chakraborti, T.K. and Pope, C. (1993). Persistent fetal brain cholinesterase inhibition induced by a single maternal dose of chlorpyrifos. Toxicologist 13: 88.

75. Pope, C., Chapman, M., diLorenzo, K. and Ehrich, M. (1993). Evidence for in situ release of a neurotrophic factor during the early stages of organophosphate-induced delayed neurotoxicity. Toxicologist 13: 212.

76. Ferguson, P.W., Bourn, W.M., Pope, C.N. and Roberts, B.L. (1993). A bachelor of science toxicology program: description, resources, student profiles and graduate placement. Toxicologist 13: 243.

77. Rao, P.S., Roberts, G.H., Pope, C.N. and Ferguson, P.W. (1993). Comparative inhibition of rodent and human erythrocyte acetylcholinesterase by carbofuran and carbaryl. Toxicologist 13: 369.

29 78. Chaudhuri, J., Chanda, S., Chakraborti, T. and Pope, C. (1993). Comparative neurotoxicity of single maximum tolerated doses of parathion and chlorpyrifos in adult rats. Toxicologist 13: 371.

79. Dalu, A., Pope, C.N. and Roberts, B.L. (1993). In vitro characterization of cholinesterase in earthworm, Eisenia fetida. Toxicologist 13: 443.

80. Chapman, M.L., Tanaka, D. Jr., and Pope, C.N. (1992). Comparison of the effects of phenylmethylsulfonyl fluoride on organophophorus induced delayed neurotoxicity in young and adult chickens. Toxicologist 12: 41.

81. Bushnell, P.J., Kelly, K.L., Pope, C.N., and Padilla, S. (1992). Persistent behavioral and neurochemical changes induced by one exposure to chlorpyrifos. Toxicologist 12: 324.

82. Pope, C.N., Arthun, D.L. Chakraborti, T.K. and Farrar, J.D. (1992). Acute chlorpyrifos treatment produces long-term neurochemical and neurobehavioral effects in adult rats. Toxicologist 12: 324.

83. Padilla, S., Moser, V.C., Brimijoin, W.S., Bennett, E. and Pope, C. (1991). Paraoxon toxicity is not potentiated by prior reduction in blood acetylcholinesterase. Toxicologist 11: 161.

84. Duncan, J.A., Bennett, E., Padilla, S. and Pope, C. (1991). The Ellman method underestimates the level of cholinesterase inhibition in tissues from carbaryl-treated rats. Toxicologist 11: 276.

85. Pope, C., Chapman, M., Arthun, D., Tanaka, D., Jr. and Padilla, S. (1991). Age and sensitivity to organophosphorus-induced delayed neurotoxicity: effects of phenylmethylsulfonyl fluoride. Toxicologist 11: 304.

86. Veronesi, B., Padilla, S., Blackmon, K. and Pope, C.N. (1990). Murine susceptibility to organophosphorus induced delayed neuropathy. Toxicologist 11: 184.

87. Pope, C.N., Chapman, M.L., Chakraborti, T.K. and Ferguson, P.W. (1990). Correlation of blood and tissue cholinesterase inhibition after parathion exposure. Toxicologist 11: 342.

88. Bushnell, P.J., Pope, C.N., Provost, V.B. and Angell, K.E. (1990). Changes in cognitive and motor function in rats dosed repeatedly with diisopropylfluorophosphate. Toxicologist 11: 343.

89. Zhang, H.X., Pope, C. and Sultatos, L.G. (1990). Biotransformation of parathion by perfused livers from male and female rats. Toxicologist 11: 345.

30 90. Padilla, S., Pope, C.N. and Lyerly, D.P. (1988). The decrease in axonal transport of proteins in the rat optic system produced by xylene inhalation is reversed by ethanol consumption. Toxicologist 8: 44.

91. Pope, C.N. and Padilla, S. (1988). Altered phosphorylation of phospholipids in hen sciatic nerve by tri-ortho-cresyl phosphate: possible role in organophosphorus-induced delayed neuropathy. Toxicologist 8: 49.

92. Wilson, V.Z., Pope, C.N. and Padilla, S. (1988). Gel exclusion chromatography of detergent solubilized neurotoxic esterase (NTE). Toxicologist 8: 172.

93. Pope, C.N. and Padilla, S. (1988). Activation of chicken brain neurotoxic esterase activity by a heat-stable factor. Programme and Abstracts, International Meeting on Esterases Hydrolyzing Organophosphorus Compounds, Dubrovnik, Croatia, April, 1988.

94. Pope, C.N. and Padilla, S. (1987). Solubilization and chromatography of neuropathy target enzyme. Toxicologist 7: 134.

95. Pope, C.N., Ho, B.T. and Wright, A.A. (1985). Neurochemical and neurobehavioral effects of acetylcholine aziridinium ion in mice. Society for Neuroscience annual meeting, Dallas, Texas.

96. Pope, C.N. and Murphy, S.D. (1984). Comparative in vitro inhibition of neurotoxic esterase and acetylcholinesterase activities in chicken, Japanese quail and bobwhite quail brain by diisopropylphosphorofluoridate. Toxicologist 4: 121.

AWARDS

Researcher of the Year, Northeast Louisiana University, 1992-1993.

Best Professor Award, 1992-1993, Pharmacy Graduate Students Association, Northeast Louisiana University.

Scientific and Technical Achievement Level III Award, U.S. Environmental Protection Agency, October 1993, for "Paraoxon Toxicity is not Potentiated by Prior Reduction in Blood Acetylcholinesterase" published in Toxicol. Appl. Pharmacol.

Excellence Award for Interdisciplinary Scholarship, Phi Kappa Phi of Michigan State University, April, 1995.

Mortar Board, Northeast Louisiana University, selected February 17, 1995 in appreciation of student mentoring.

Pfizer Award for Research Excellence, College of Veterinary Medicine, Oklahoma State University, April, 2001.

Regents Distinguished Research Award, Oklahoma State University, May 11, 2005.

Regents Professor, Oklahoma State University, July, 2007.

Regents Distinguished Research Award, Oklahoma State University, January, 2016

INVITED PRESENTATIONS

Speaker, Second International Meeting on Esterases Hydrolyzing Organophosphorus Compounds, Salsomaggiore, Italy, April 21-24, 1992.

Speaker, 5th International Meeting on Cholinesterases, Madras, India, September 24-28, 1994.

Speaker, DowElanco Workshop on Chlorpyrifos, Chapel Hill, NC, February 6-8, 1996.

Speaker, 3rd National Health and Environmental Effects Research Laboratory (NHEERL) Symposium, Susceptibility and Risk, Durham, N.C., September 26, 1996.

Invited Seminar, “Age-related differences in sensitivity to organophosphate pesticides”, Johns Hopkins School of Hygiene, Baltimore, MD, September 23, 1996.

Member, Working Group on Common Mechanisms of Toxicity, International Life Sciences Institute, Washington, D.C., March-August, 1997.

Member, Expert Panel, Diazinon: Aggregate Risk Assessment, Novartis Crop Protection, Greensboro, NC, November 21, 1997.

Invited Seminar, “Presynaptic modulation of anticholinesterase toxicity”, Duke University Interdepartmental Program in Toxicology, Durham, NC, December 1, 1997.

Invited Seminar, “Differential in vitro and in vivo actions of organophosphorus insecticides”, Dow Agrosciences, Indianapolis, Indiana, June 4, 1998.

Invited Seminar, “Are young more sensitive than adults to chlorpyrifos: animal studies”, Chlorpyrifos and Human Health: Data Considerations under FQPA, Washington, DC, October 20, 1998.

Invited Seminar, “Presynaptic modulation of organophosphate neurotoxicity, Medical College of Virginia, Richmond, VA, January 28, 1999.

Invited Seminar, “Presynaptic modulation of organophosphate neurotoxicity, University of Kentucky, Lexington, KY, February 9, 1999.

32 Member, Panel on the Need for an Additional Uncertainty Factor for Children, The FQPA: A Challenge for Science Policy and Pesticide Regulation, Fairfax, VA, March 23, 1999.

Invited Seminar, “Differential toxicity of organophosphorus insecticides: implications for FQPA”, Oklahoma State University, Stillwater, OK, May 26, 1999.

Invited Seminar, Age-related differences in sensitivity to chlorpyrifos are markedly incluenced by magnitude and frequency of exposure”, 7th Meeting of the International Neurotoxicology Association, Leicester, United Kingdom, July 8, 1999.

Session Chair, “New developments in the understanding of organophosphorus toxicology”, 7th Meeting of the International Neurotoxicology Association, Leicester, United Kingdom, July 4, 1999.

Invited Seminar, “Age-related differences in sensitivity to organophosphate insecticides”, School of Public Health, Shanghai Medical University, Shanghai, China, April 10, 2000.

Invited Seminar, “Presynaptic modulation of organophosphate neurotoxicity”, Life Sciences and Clinical Medicine 2000, Beijing, China, April 19, 2000.

Invited Seminar, “Age-related differences in sensitivity to organophosphates”, Oklahoma Center for Toxicology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, May 19, 2000.

Invited Seminar, “Toxicokinetic and toxicodynamic factors in differential sensitivity to anticholinesterases during maturation and aging”. Mayo Clinic, Rochester, MN, October 28, 2000.

Session Chair, Poster Discussion Panel, American College of Toxicology annual meeting, November 13, 2000, San Diego, CA.

Invited Seminar, Duke University Integrated Toxicology Program and Superfund Center Symposium, “Age-related differences in sensitivity to acute and repeated organophosphorus insecticide exposures”, December 4, 2000.

Invited Seminar, “Running and restraint stress fail to influence pyridostigmine-induced acetylcholinesterase inhibition in rat brain”, Conference on Illnesses Among Gulf War Veterans: A Decade of Scientific Research, Alexandria, VA, January 25, 2001.

Invited Seminar, “Toxicokinetic and toxicodynamic factors in differential sensitivity to organophosphorus insecticides during maturation and aging”, Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, February 7, 2001.

33 Invited Seminar, “Toxicokinetic and toxicodynamic factors in differential sensitivity to organophosphorus insecticides”, International Neurotoxicology Association meeting, Estoril, Portugal, June 13, 2001.

Invited Seminar, “Influence of age on pesticide toxicity”, Department of Zoology, Oklahoma State University, Stillwater, OK, September 21, 2001.

Invited Seminar, “Age and Sensitivity to Pesticides”, School of Public Health, Sun Yat-Sen University for Medical Sciences, Guangzhou, China, October 15, 2001.

Invited Seminar, “Influence of Age on Pesticide Toxicity”, 3rd Chinese Society of Toxicology meeting, Nanjing, China, October 17, 2001.

Invited Seminar, “Non-esterase actions of organophosphorus insecticides”, University of Rhode Island, Kingston, RI, January 22, 2003.

Session Chair, “Cumulative risk assessment: getting from toxicology to quantitative analysis of mixed exposures”, March 10, 2003. Annual meeting of the Society of Toxicology meeting, Salt Lake City, UT.

Invited Seminar, “Interactive toxicity of organophosphorus insecticides”, March 10, 2003, Annual meeting of the Society of Toxicology, March 10, 2003.

Symposium Chair, “Cholinesterase inhibitors: from therapeutics to terrorism”, 9th meeting of the International Neurotoxicology Association, Dresden, Germany, June 23, 2003.

Invited Seminar, “Pharmacological and toxicological actions of cholinesterase inhibitors: use and misuse of a common mechanism”. 9th meeting of the International Neurotoxicology Association, Dresden, Germany, June 23, 2003.

Invited Speaker, “Interactive toxicity of organophosphorus insecticides”, College of Health and Science, Kaohsiung Medical University, November 3, 2003.

Symposium Speaker, “Cholinesterase inhibitors: therapeutics to terrorism”, International Environmental Toxicology and Medicine, Taipei, Republic of China, November 7, 2003.

Invited Speaker, “Cholinesterase inhibitors: From Clinical Practice to Urban Terror”, Plant Pathology and Entomology, Oklahoma State University, Stillwater, OK, April 28, 2004.

Invited Speaker, “Cholinesterase inhibitors: uses and misuses of a common mechanism of action”. Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, Feburary 28, 2005.

Session Chair, Neurotoxicity: Pharmacological and Environmental Interactions, Society of Toxicology annual meeting, March 7, 2005, New Orleans, LA.

Invited Speaker, “Organophosphates and Carbamates: Uses and Misuses of a Common Mechanism”, Society of Toxicology annual meeting, March 8, 2005, New Orleans, LA.

Session Chair, Organophosphates and Carbamates: Cholinergic vs Noncholinergic Mechanisms, Society of Toxicology annual meeting, March 8, 2005, New Orleans, LA.

Session Chair, “Neurotoxicants and Chemical Terrorism: Molecular Mechanisms and Medical Responses”, 10th Meeting of the International Neurotoxicology Association, Porvoo, Finland, June 27, 2005.

Invited Speaker, “Neurotoxicants and chemical terrorism: subpopulation considerations”, 10th Meeting of the International Neurotoxicology Association, Porvoo, Finland, June 27, 2005.

Invited Speaker, “Exposure sequence influences cholinergic toxicity in neonatal rats exposed to two organophosphorus insecticides”, 22nd International Neurotoxicology Conference, Research Triangle Park, NC, September 14, 2005.

Invited Speaker, “Aging and sensitivity to organophophoshorus insecticides: toxicokinetic and toxicodynamic factors”. April 3, 2006, Experimental Biology annual meeting, San Francisco, CA.

Invited Speaker, “Aging and sensitivity to organophosphorus insecticides”, Symposium: The Aging Population as a Sensitive Subgroup, California Environmental Protection Agency, April 10, 2006, Monterrey, CA.

Invited Speaker, “Aging and sensitivity to organophosphorus insecticides”, Nutritional Sciences Department, Oklahoma State University, Stillwater, OK, April 12, 2006.

Invited Speaker, “Aging and sensitivity to organophosphorus insecticides”, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, April 18, 2006.

Visiting Fellow, Big 12 Faculty Fellowship program, Department of Biomedical Sciences, College of Veterinary Medicine, April 17-21, 2006.

Invited Seminar, “Age-related sensitivity to organophosphorus insecticides”, Interdisciplinary Faculty of Toxicology, College of Veterinary Medicine, Texas A&M University, College Station, TX, May 1, 2006.

Invited Seminar, “Endocannabinoid signaling and organophosphate toxicity”, Medical College of Georgia, Augusta, GA, February 22, 2008.

35 Invited Speaker and Session Chair, “Modulation of neurotoxicity by endocannabinoid signaling”. International Neurotoxicology Conference, Rochester, NY, October 13, 2008.

Invited Speaker and Symposium Chair, “Modulation of anticholinesterase toxicity by endocannabinoid signaling” 12th meeting of the International Neurotoxicology Association, Jerusalem, June 8, 2009.

Invited Speaker, “Comparative toxicity of organophosphorus insecticides in adult and aging rats”, Annual meeting of the Society of Toxicology, Salt Lake City, UT, March 10, 2010.

Invited Seminar, “Endocannabinoids and organophosphate toxicity”. Vanderbilt University, Nashville, TN, October 24, 2012.

Invited Speaker, “Effects of parathion and chlorpyrifos on extracellular endocannabinoid levels: influence on cholinergic toxicity”, Society of Toxicology annual meeting, San Antonio, TX, March 12, 2013.

Invited Seminar, “Endocannabinoids and organophosphate toxicity”, Clemson University, Clemson, SC, April 23, 2013.

Invited Seminar, “Endocannabinoids and organophosphate toxicity”, Mayo Clinic, Rochester, MN, April 26, 2013.

Invited Presentation, “Nanocarrier-mediated Targeting of Bioscavengers to the Red Blood Cell for Prolonged Circulation and Protection”, Defense Threat Reduction Agency, Washington DC, November 11, 2013.

Invited Seminar, “Endocannabinoids, nano-scavengers and organophosphate toxicity”, OSU Center for Health Sciences, Tulsa, OK, February 7, 2014.

Invited Presentation, “Organophosphate toxicity, endocannabinoids and nanoscavengers”, April 24, 2015, East Tennessee State University, Johnson City, TN.

Invited Presentation, “Erythrocytes as targeted carriers for nanoencapsulated butyrylcholinesterase”. 12th Cholinesterase Meeting, Elche, Spain. September 27, 2015.

Invited Seminar, “Organophosphates, endocannabinoids and nanoscavengers”. Biochemistry and Molecular Biology Department, Oklahoma State University, Stillwater, November 6, 2015.

36 Invited Seminar, “The biology and toxicology of cholinesterases”. Environmental Sciences, University of California Riverside, Riverside, CA, May 27, 2017.

Invited Seminar, “Cholinesterases: intersection of physiology, pharmacology and toxicology”. Baylor University, Waco, TX, October 4, 2017.

Invited Seminar, The biochemistry and toxicology of cholinesterases”, Natural Resources and Environmental Science, University of Nevada, Reno, NV, January 30, 2018

FEDERAL/STATE GOVERNMENT ADVISORY SERVICE

Scientific Advisory Panel, Colloquium on Risk Assessment for Cholinesterase Inhibitors, Office of Research and Development, U.S. Environmental Protection Agency, Washington, D.C., June 30, 1988.

Scientific Advisory Panel, Policy Statement for Cholinesterase Inhibitors, Office of Research and Development, U.S. EPA, Washington, D.C., November 5-6, 1992.

Scientific Advisory Panel, Meeting on Guideline Issues, U.S. Environmental Protection Agency, Washington, D.C., December 13-14, 1993.

Grant Review Panel, Department of Defense Animal Models Panel for Gulf War Veterans’ Illnesses, Washington, DC, April 16-19, 1997.

Grant Review Panel, Department of Defense Physical Environment Panel for Gulf War Veterans’ Illnesses, Washington, DC, May 11-13, 1997.

Scientific Advisory Panel, Science Policy on the Use of Cholinesterase Inhibition for Risk Assessments of Organophosphate and Carbamate Pesticides, Office of Pesticide Programs, U.S. Environmental Protection Agency, Washington, DC, June 3-4, 1997.

Scientific Advisory Panel, External Peer Review for Carbofuran. Office of Pesticide Programs, U.S. Environmental Protection Agency, Washington, DC, August 26, 1997.

Study Section, NIEHS, Special Emphasis Panel, Centers for Children’s Environmental Health and Disease Prevention Research, March 23-25, 1998, Research Triangle Park, NC.

Program Review Panel, U.S. Army Medical Research and Materiel Command Chemical Defense Science and Technology Objectives: Chemical Agent Prophylaxes, Hunt Valley, Maryland, June 1-2, 1998.

Grant Review Panel, Sensitive Subpopulations, U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, June 25, 1998.

Scientific Advisory Panel, Time Sensitive Reversibility of Aldicarb induced Cholinesterase Inhibition as a Factor in Acute Dietary Risk Assessment, U.S. Environmental Protection Agency, Washington, DC, February 23, 1999.

Study Section, NIEHS, Special Emphasis Panel, Environmental Agents and Neurodevelopmental Abnormalities, April 22-23, 1999, Research Triangle Park, NC.

Study Section, NIEHS, ad hoc member of ALTOX3, June 24-25, 1999, Santa Barbara, CA.

Scientific Advisory Panel, A Consultation on Protocol Design to Assess Acute Neurotoxicity Studies following Oral Administration of Pesticides, U.S. Environmental Protection Agency, Washington, DC, July 21, 1999.

Proposal Reviewer, “Development of a biosensor method for the analysis of organophosphorus compound-induced acute and delayed neurotoxicity”, United States Department of State, Civilian Research and Development Foundation, August, 1999.

Proposal Reviewer, “Cholinergic drug delivery to the nervous system”, United States Army, August, 1999.

Scientific Advisory Panel, Identifying Carbamate Pesticides that have a Common Mechanism of Toxicity. U.S. Environmental Protection Agency, Washington, DC, September 22, 1999.

Program Review Panel, U.S. Army Medical Research and Materiel Command Chemical Defense Science and Technology Objectives: Chemical Agent Prophylaxes, Hunt Valley, Maryland, June 4-6, 2000.

Program Review Panel, U.S. Army Medical Research and Materiel Command Chemical Defense Science and Technology Objectives: Low Dose/Chronic Exposure to Toxicants, Hunt Valley, Maryland, June 6-7, 2000.

Grant Review Panel, Department of Defense Gulf War Illnesses Research 2000, Washington, DC, September 11-12, 2000.

Scientific Advisory Panel, End Point Selection and Determination of Relative Potency in Cumulative Hazard Assessment: A Pilot Study of Organophosphorus Pesticide Chemicals. U.S. Environmental Protection Agency, Washington, DC, 9/27/2000.

Grant Review Panel, Department of Defense, Defense Health Research Program, Washington, DC, October 19-20, 2000.

Scientific Advisory Panel, Preliminary cumulative hazard and dose-response assessment for organophosphorus pesticide: determination of relative potency and points of departure for

38 cholinesterase inhibition. U.S. Environmental Protection Agency, Washington, DC, September 5-6, 2001.

Scientific Advisory Panel, Determination of the appropriate FQPA safety factor(s) in the organophosphorus pesticide cumulative risk assessment: susceptibility and sensitivity to the common mechanism, acetylcholinesterase inhibition. U.S. Environmental Protection Agency, Washington, DC, June 26-27, 2002.

Grant Review Panel, Environmental Protection Agency, Biomarkers for the assessment of exposure and toxicity in children. Washington, DC, August 23, 2002.

Program Review Panel, Toxicologic Assessment of Low-Level Exposures to Chemical Warfare Agents, National Academy of Sciences, Washington, DC, March 6-7, 2003.

Proposal Reviewer, “Engineering of a highly efficient recombinant arylesterase and evaluation of its activity against nerve poisons in animal models”, United States Army, May, 2003.

Study Section, NIEHS, Special Emphasis Panel, Centers for Children’s Environmental Health and Disease Prevention Research, Research Triangle Park, NC, August 4-6, 2003.

Peer Reviewer, Toxicological Review of Aldicarb, Aldicarb Sulfoxide and Aldicarb Sulfone for the Integrated Risk Information System (IRIS), United States Environmental Protection Agency, August, 2003.

Peer Reviewer, Uniformed Services University for Health Sciences, Exploratory Research Program, February, 2004.

Study Section, NIEHS, ad hoc reviewer, Neurotoxicology and Alcohol, June 14-15, 2004.

External Reviewer, Cholinesterase Inhibition and its application in risk assessment, Department of Pesticide Regulation, Sacramento, CA, September, 2004.

Study Section, NIEHS, ad hoc reviewer, Neurotoxicology and Alcohol, October 21-22, 2004.

Scientific Advisory Panel, Dimethoate: Issues related to the hazard and dose-response assessment. U.S. Environmental Protection Agency, Washington, DC, November 30- December 1, 2004.

Study Section, NIEHS, ad hoc reviewer, Neurotoxicology and Alcohol, February 17-18, 2004.

Study Section, NIEHS, ad hoc reviewer, Neurotoxicology and Alcohol, June 9-10, 2005.

Study Section, NIEHS, ad hoc reviewer, Neurotoxicology and Alcohol, October 17-18, 2005.

Study Section, NIEHS, ad hoc reviewer, Neurotoxicology and Alcohol, February 16-17, 2006.

Study Section, Neurotoxicology and Alcohol, Appointed “standing” member, April, 2006.

Study Section, Neurotoxicology and Alcohol, June 13-14, 2006.

Chair, Special Emphasis Panel, National Institute of Environmental Health Sciences, April 12, 2006.

Special Emphasis Panel, CounterACT Program, National Institute of Neurological Disorders and Stroke, July 13, 2006.

Study Section, Neurotoxicology and Alcohol, February 7, 2007.

Peer Reviewer, Defense Threat Reduction Agency Basic Research Program, U.S. Army, September, 2007.

Study Section, Neurotoxicology and Alcohol, October 11-12, 2007.

Special Emphasis Panel ZES1 LKB-C, National Institute of Environmental Health Sciences, Research Triangle Park, NC, March 5, 2008 (phone reviewer).

Special Emphasis Panel ZRG1 IFCN-A (03) M, National Institute of Environmental Health Sciences, July 14-15, 2008 (online review).

Scientific Advisory Panel, Agency’s Evaluation of the Toxicity Profile of Chlorpyrifos, U.S. Environmental Protection Agency, Washington, DC, Sept 15-19, 2008.

Special Emphasis Panel ZRG1 IFCN-A (02) M, National Institute of Environmental Health Sciences, October 6, 2008 (online review).

Study Section, Superfund Basic Research and Training Program (P42), National Institute of Environmental Health Sciences, November 5-7, 2008, Durham, NC.

Special Emphasis Panel ZRG1 IFCN-A (58) R, Ethanol and Neurotoxicology, Challenge Grant Review (online), June 6, 2009.

Special Emphasis Panel ZRG1 BDCN-T (58) R, Brain Disorders and Clinical Neuroscience, Challenge Grant Program, June 25, 2009.

Special Emphasis Panel ZRG1 IFCN-A (03) M, Member Conflict: Ethanol and Neurotoxicology, July 14-15, 2009.

Scientific Advisory Panel, Evaluation of Updated Standard Operating Procedures for Residential Exposure Assessment, October 6-9, 2009, Washington, DC.

40 Scientific Advisory Panel, Issues Associated with Field Volatilization of Conventional Pesticides, December 1-4, 2009, Washington, DC.

Scientific Advisory Panel, Draft Framework and Case Studies on Atrazine, Human Incidents and the Agricultural Health Study, February 2-4, 2010, Washington, DC.

Special Emphasis Panel ZRG1 IFCN-E 02 M, Member Conflict: Neuroadaptations. April 19-21, 2010.

Scientific Advisory Panel, Comparative Adult and Juvenile Sensitivity Toxicity Protocols for Pyrethroids, July 20-23, 2010, Washington, DC.

Scientific Advisory Panel, Re-evaluation of the Human Health Effects of Atrazine: Review of Non-Cancer Effects and Drinking Water Monitoring Frequency, September 14-17, 2010, Washington, DC.

Special Emphasis Panel 2011/01 ZRG1 MDCN-A (03), Molecular, Cellular and Developmental Neurosciences Integrated Review Group. October 28, 2010.

Reviewer, Medical Research Council (UK) proposal entitled “The identification of stress responses to neuronal dysfunction as indicators of risks from exposure to pesticides”. November 2, 2012.

Special Emphasis Panel, ZRG1 MDCN-J (50), CounterACT program grant review panel, NIH, Washington DC, March 19, 2013.

Special Emphasis Panel, ZRG1 MDCN-J (54), CounterACT program grant review panel, NIH, Washington DC, March 19, 2013.

Panel Member, Neurological Effects after Chemical Nerve Agent Exposures workshop, National Institutes of Health, Bethesda, MD, February 26-27, 2014.

EDITORIAL ROLES

Member, Editorial Board: Journal of Toxicology and Environmental Health (1995-2018) International Journal of Toxicology (2000-2013) Toxicological Sciences (2001-present) Toxicology (2003-present) Toxicology Letters (2003-2012). Toxicology and Applied Pharmacology (2003-present) Journal of Environmental Science and Health Part C (2006-present) NeuroToxicology (2007-present) Archives of Toxicology (2009-2015) EXCLI Journal (2011-present)

Associate Editor: Journal of Pharmacology and Therapeutics (2004-present); NeuroToxicology (2017-present) Encyclopedia of Toxicology, Academic Press (1994-1997), Second edition (2002-2005), Third edition (2010-2011).

ROLE AS MENTOR

Faculty

Jill Ackerman, Associate Professor of Anatomy, Center for Veterinary Health Sciences, Oklahoma State University. Member, faculty mentoring committee. Madhan Subramanian, Assistant Professor of Anatomy, Center for Veterinary Health Sciences, Oklahoma State University. Member, faculty mentoring committee.

Visiting Professor

Andrea Holgado, Summer 2014. Project: Silver nanoparticle toxicity in C. elegans. Supported by NSF EPSCoR Research Opportunity Award. Current position, Associate Professor and Head, Department of Biology, Southwestern Oklahoma State University, Weatherford, OK. Liming Zou, January 2002-December 2002. Project: Effects of OP toxicants on G-protein receptor kinase-mediated phosphorylation of M2 receptors. Current position, Professor and Chair, Department of Biochemistry, Shenyang Medical College, Shenyang, China.

Research Associate Professor

Jing Liu, 2014-2017. Project: OP toxicity, modulation of neurotoxicity, non-cholinergic signaling in OP toxicity.

Research Assistant Professor

Subramanya Karanth, 2001-2009. Project: Effects of OP toxicants on acetylcholine release in vivo; interactive toxicity.

Postdoctoral Associate

Dave Arthun, 1990-1991. Project: Age-related differences in sensitivity to organophosphorus pesticides.

Tamal Chakraborti, 1993-1995. Project: Role of acetylcholine release in modulation of anticholinesterase-induced neurotoxicity. Current position, Senior Staff Fellow, Food and Drug Administration, Washington, DC.

42 Quan Zheng, 1998-2000. Project: Cellular mechanisms of age-related differences in sensitivity to organophosphorus insecticides.

Jing Liu, 1998-2000. Project: Mechanisms of interactive neurotoxicity of organophosphorus insecticides. Current position, Research Associate Professor, Oklahoma State University.

Yi-Jun Wu, 1999-2000. Project: Nicotinic autoreceptor function and sensitivity to organophosphate insecticides. Current position, Professor, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Hengshan Zhang, 1998-2001. Project: Age-related differences in effects of organophosphorus pesticides on receptor-mediated signaling. Current position, Research Associate, University of Rochester, Rochester, NY.

Subramanya Karanth, 1998-2001. Project: Age-related differences in biotransformation, interactive toxicity of organophosphorus pesticides. Current position, Assistant Research Professor, Oklahoma State University.

Hailin Tian, 2000-2001. Project: Stress and sensitivity to anticholinesterases.

Gangduo Wang, 2000-2001. Project: Muscarinic autoreceptor function and anticholinesterase toxicity.

Dibyendu Chakraborty, 2002-2003. Project: Effects of OP toxicants on m2 muscarinic receptor-syntaxin interactions. Current position, Postdoctoral associate, University of Oklahoma, Oklahoma City.

Jamaluddin Shaikh, 2002-2004. Project: Stress-induced blood brain barrier alterations and sensitivity to anticholinesterases. Current position, Research Associate, University of Mississippi, Oxford, MI.

Anamika Ray, 2005-2008. Project: Genomic changes following chlorpyrifos exposure in neonatal rat brain.

Linnzi Wright, 2006-2009. Project: Persistent neurobehavioral effects of organophosphate intoxication.

Genny Fent, 2010-2012. Project: Serotonergic signaling in persistent behavioral effects of DFP.

Pallavi Shrivastava, 2011-2012. Project: Cannabinoid and 5HT Receptor changes following anticholinesterase exposure.

Randall Maples, 2012-2013. Project: Monoamine and endocannabinoid levels following acute OP intoxication.

43 Sindhura Ramasahayam, 2012-2013. Project: Non-cholinergic neurotransmitter release following organophosphate exposure.

Ravindra Satpute, 2014-2015. Project: Non-cholinergic transmitters in organophosphate toxicity.

44 Doctoral

Tamal Chakraborti, Ph.D. Graduated 1993. Dissertation title: Comparative neurochemical effects of organophosphate insecticides in neonatal and adult rats, University of Louisiana. Current position, Senior Staff Fellow, U.S. FDA.

Sushmita Chanda, Ph.D. Graduated 1995. Dissertation title: Comparative maternal and developmental neurotoxicity following gestational exposure to chlorpyrifos in rats, University of Louisiana. Current position, Scientist, Roche Bioscience, Alto, CA.

Jing Liu, Ph.D. Graduated 1998 (co-major advisor, Paul Ferguson). Dissertation title: Mechanisms of presynaptic and postsynaptic modulation of anticholinesterase toxicity, University of Louisiana. Current position, Research Scientist, Oklahoma State University.

Paul Harp, Ph.D. Graduated 1998. Dissertation title: Nicotinic autoreceptor function and anticholinesterase toxicity, University of Louisiana. Current position, Senior Toxicologist, R.J. Reynolds, Winston-Salem, N.C.

Marcia Howard, Ph.D. Graduated 2002. Dissertation title: Direct and indirect modulation of cardiac muscarinic receptors by organophosphorus insecticides, University of Louisiana. Current position, Director, Regulatory and Scientific Affair, Consumer Healthproducts Safety Association, Washington, DC.

Kenneth Olivier, Jr., Ph.D. Graduated 2002. Dissertation title: High affinity choline uptake and its influence on age-related differences in sensitivity to organophosphorus insecticides, Oklahoma State University. Current position, Senior Scientist, Glaxo, Research Triangle Park, NC.

Xun Song, M.D., Ph.D. Graduated 2003. Dissertation title: Stress, pyridostigmine and blood brain barrier. Oklahoma State University. Current position, Senior Scientist, Merck, Princeton, NJ.

Anuradha Nallapaneni, BVScAH, PhD. Graduated 2008. Disseration title: Modulation of cholinergic toxicity by cannabinergic compounds.

Nikita Mirajkar, BVScAH, PhD. Graduated 2008. Disseration title: Cholinergic modulation of cardiac function: selective disruption by organophosphorus anticholinesterases.

Yongbin Zhang, DVM, PhD. Graduated 2008. Dissertation title: Pharmacologic and Toxicologic Effects of Nanomaterials.

Praveena Baireddy, BVSc, PhD. Graduated 2009. Dissertation title: Presynaptic cholinergic and cannabinergic signaling in the expression of organophosphate toxicity.

Kirstin Poindexter Hester, BS., PhD. candidate. Dissertation project: Butyrylcholinesterase as an organophosphate bioscavenger.

Master’s

Mark Chapman, M.S. (Ph.D., University of North Carolina, Chapel Hill, NC). Graduated 1992. Thesis title: The effect of phenylmethylsulfonyl fluoride on the clinical markers of organophosphorus-induced delayed neurotoxicity in immature and adult chickens, University of Louisiana. Current position, Scientist, Research Triangle Institute, Research Triangle Park, NC.

John Farrar, M.S. Graduated 1992. Thesis title: Neurobehavioral effects of single and multiple exposures to the organophosphate insecticide chlorpyrifos in adult and neonatal rats, University of Louisiana. Current position, Scientist, US Army Engineer Waterways Experiment Station, Vicksburg, MS.

Yen-Kim Won, M.S. Graduated 2000. Thesis title: Muscarinic autoreceptor function and age- related differences in sensitivity to chlorpyrifos, University of Louisiana, Monroe. Current position, Principal scientist, Johnson and Johnson, New Brunswick, NJ.

Raju Kacham, DVM, MS. Graduated 2003. Thesis title: Mechanisms of interactive toxicity of organophosphorus insecticides in neonatal rats. Private practice.

Elmar Udarbe, DVM, MS (Fulbright Scholar), Graduated 2004. Thesis title: Effect of chlorpyrifos oxon on regulation of muscarinic M2 receptors. Private practice.

Tim Anderson, BS, MS. Graduated 2017. Thesis title: Comparative effects of organophosphates in mice and the Great Plains toad. Current position, PhD student, University of Rochester.

Stacey Herriage, BS, MS candidate. Thesis topic: PPAR signaling and organophosphate toxicity.

Gradute Student Advisory Committee Member

Prathibha Rao, M.S., 1992, Comparative Inhibition of Rodent and Human Erythrocyte Anticholinesterase by Selected Carbamate Insecticides, University of Louisiana.

Danny Ray Hoston, M.S., 1992, Synthesis of N-alkyl sulfonyl fluorides and study of their effects on hen brain neurotoxic esterase, University of Louisiana.

Usha Arvindan Pilai, Ph.D., 1993, Effect Of Bleomycin-Induced Fibrosis On Pulmonary Metabolism Of Selected Xenobiotics In Sprague Dawley Rats, University of Louisiana

Micheal Edward Honeycutt, Ph.D., 1993, Assessment Of The Earthworm, Eisenia Fetida As A Biomarker Species Using Selected Dispositional Processes And Biological Endpoints, University of Louisiana

46 Ajita Rao, M.S., 1993, Synthesis Of Quinoxaldinediones As Possible Endogenous Flavin Metabolites With Potential For Activity In Excitatory Amino Acid Neurotransmitter System, University of Louisiana

Jianbo Zhang, M.S., 1993, Synthesis of thiophosphate derivatives and study of their neurotoxicological effects in mice, University of Louisiana

Ahmed A. Adloo, Ph.D., 1996, Evaluation Of Piperidinecarboxylic Acid Derivatives As Potential Anticonvulsants, University of Louisiana

Jane Marie Heslop Feldhaus, Ph.D., 1996, A Toxicokinetic Model For Determination And Prediction of Biota-Sediment Accumulation Factor for PCB-52, University of Louisiana

Prathibha Sunder Rao, Ph.D., 1996, Tissue Repair Dynamics And Impact Of Nutrition On Cell Proliferation, University of Louisiana

Shengquan Liu, Ph.D., 1997, Synthesis Of Nonpeptide Somatostatin Receptor Agonists, University of Louisiana

Shou Zhao, M.S., 1998, The Effects Of A Selenium Enriched Diet On T2 Toxin Induced Immunotoxicity In Balb/C Mice, University of Louisiana

Jeffrey Kyle Bounds, Ph.D., 1998, Evaluation of Central ATP-Sensitive K+ Channels In The Control Of Feeding Behavior, University of Louisiana

Shashikumar Ramaiah, Ph.D., 1999, Mechanisms Of Liver Injury And Tissue Repair In Thioacetamide Hepatotoxicity Following Diet Restriction, University of Louisiana

Kimberly D. Owens, M.S., 1999, Evaluation Of The Japanese Medaka (Oryzias Latipes) Embryo Larval Assay To Assess The Extractable Organic Phase Toxicity Of Contaminated Sediments, University of Louisiana

Tao Wang, Ph.D., 2000, Enhanced Hepatotoxicity And Toxic Outcome Of Thioacetamide In Streptozotocin-Induced Diabetic Rats, University of Louisiana

Asim Kart, Ph.D. 2003. Modulation of lasalocid toxicity in rats and chickens by phenyl methyl sulfonyl fluoride, Oklahoma State University.

Eva Garringer, Ph.D. 2005, Major advisor Doris Patneau, Assistant Professor of Anatomy and Cell Biology, OSU-College of Osteopathic Medicine, Tulsa, OK.

Zhongming Chen, Ph.D. 2005, Major advisor Lin Liu, Associate Professor of Physiological Sciences, OSU.

47 Nili Jin, Ph.D., 2005, Major Advisor Lin Liu, Associate Professor of Physiological Sciences, OSU.

Xinrong Chen, Ph.D., 2005. Major Advisor Guangping Chen, Associate Professor of Toxicology, OSU.

Latha Devareddy, Ph.D. 2005, Major Advisor Bahram Arjmandi, Professor of Nutritional Sciences, OSU.

Yugendar Bommineni, Ph.D. 2008, Major advisor Guolong Zhang, Associate Professor of Animal Science, OSU.

Siwei Liu, Ph.D. 2008. Major advisor Haobo Jiang, Associate Professor of Entomology, OSU.

Kimberly Hays, Ph.D. 2009. Major advisor Karen McBee, Professor of Zoology, OSU.

Melissa Valentine-Cordero, DVM, PhD 2011. Major advisor Dianne McFarlane, Associate Professor of Physiological Sciences, OSU.

Amarjit Mishra, PhD, 2011. Major advisor Lin Liu, Lundberg-Kienlen Professor of Biomedical Research, OSU. Graduated, 2011.

Randall Maples, PhD, 2012. Major advisor Kevin Ausman, Assistant Professor of Chemistry, OSU.

Manushree Bharadwaj, Ph.D. candidate, Major advisor Lara Maxwell, Associate Professor of Pharmacology, CVHS, OSU.

Beth Hillburn, PhD, 2013. Major advisor Kevin Ausman, Assistant Professor of Chemistry, OSU.

Rangika S. Hikkaduwa Koralege, PhD, 2014. Major advisor, Kevin Ausman, Assistant Professor of Chemistry, OSU.

Patrick Cusaac, PhD, 2016. Major Advisor Dr. Scott McMurry, Regents Professor, Department of Integrative Biology, OSU.

Carrie German, PhD, 2017. Major advisor Dr. Sundararajan Madihally, Department of Chemical Engineering, OSU.

Nicholas Flynn, PhD, 2017. Major advisor Dr. Josh Ramsey, Department of Chemical Engineering, OSU.

Jimmy Lovett, PhD candidate. Major advisor Dr. Karen McBee, Department of Integrative Biology, OSU.

Josh VanOsdol, PhD. Candidate. Major advisor Dr. Ashish Ranjan, Physiological Sciences, OSU.

VETERINARY STUDENT RESEARCH TRAINING

Elaine Salmon, Summer, 2001. Project: Effects of physical stress on pyridostigmine toxicity in rats.

Larae Mason, Summer, 2003. Project: In vivo cholinesterase inhibition in horses treated with the feed-through larvacide Equitrol.

Angie Abbey, Summer, 2004. Project: Effects of sugar feeding on parathion-induced changes in acetylcholine release in vivo.

Amber Hodges, Summer 2013. Project: Characterization and in vitro sensitivity of acetylcholinestearase from canine heartworm to selected organophosphorus inhibitors.

John Evans, Summer 2014. Project: Effects of cannabinoid receptor antagonist AM251 on toxicity of chlorpyrifos in mice.

Kristen Clark, 2014-2015. Project: Pharmacological modulation of nitric oxide signaling and parathion toxicity. OTHER STUDENT RESEARCH TRAINING

Nicole Sutter, NIH-supported project entitled Native Americans in Biological Science, Summer- Fall, 2004. Project: Effects of sugar feeding on malathion toxicity.

Cherie Ognibene, INBRE-supported project for undergraduate students, Summer 2007. Project: Evaluation of carbon nanotube toxicity.

Amanda Likins, Howard Hughes Medical Institute-supported project for undergraduate students, Summer 2007-Spring 2008. Project: Cannabinoids and OP toxicity.

Kirstin Poindexter, B.S. Microbiology student, July, 2014-August 2015. Project: Sequestration of paraoxon by nano-encapsulated butyrylcholinesterase.

Gil Repa, BS Biochemistry student, HHMI Freshman Research Scholar Program, August 2015- May 2016. Project: Paraoxon degradation by mutant butyrylcholinesterase.

Dominique Davis, BS Biochemistry student, HHMI Freshman Research Scholar Program, August 2015-May 2016. Project: amphibian brain esterase sensitivity to organophosphates.

Kori McClay, BS Biochemistry student, HHMI Freshman Research Scholar Program, August 2017-present. Project: effects of butyrylcholinesterase inhibition on ghrelin-induced food intake.

EXPERT WITNESS TESTIMONY

Henslee vs. Farnam. Harris County, Houston, Texas, November 2002. This case involved the possible toxicity of a common feed-through larvacide containing the organophosphorus insecticide tetrachlorvinphos.

Wrather vs. Farnam. Santa Ana, California. March, 2004. This case also involved the possible toxicity of a common feed-through larvacide containing the organophosphorus insecticide tetrachlorvinphos. PROFESSIONAL TRAINING

Excelling as a First-Time Manager or Supervisor, Oklahoma City, OK, March, 2004.

Using Observations of Teaching to Promote Reflection and Improvement, Oklahoma State University, November, 2006.

How to Supervise People, Oklahoma City, OK, March, 2007

RECENT UNIVERSITY COMMITTEE SERVICE

Chair, Research Advisory Committee, Oklahoma State University College of Veterinary Medicine, 2001-2003.

Member, ad hoc Committee on Tenure and Promotion, Department of Physiological Sciences, Oklahoma State University College of Veterinary Medicine, 2002.

Member, Pharmacologist search committee, Department of Physiological Sciences, Oklahoma State University College of Veterinary Medicine, 2003.

Member, Tenure and Promotion Committee for Dr. Mike Davis, Department of Physiological Sciences, Oklahoma State University College of Veterinary Medicine, 2003.

Member, Strategic Planning Committee, Department of Physiological Sciences, Oklahoma State University College of Veterinary Medicine, 2004.

Member, Departmental Strategic Planning Committee, Department of Physiological Sciences, Oklahoma State University College of Veterinary Medicine, 2004.

Member, Veterinary Faculty Council, Oklahoma State University College of Veterinary Medicine, 2004-2005.

50 Chair, Veterinary Faculty Council, Oklahoma State University College of Veterinary Medicine, 2004-2005.

Member, Biosafety Officer Search Committee, Oklahoma State University, 2004.

Member, Advancement Leadership Team, Center for Veterinary Health Sciences, Oklahoma State University, 2005.

Member, Reappointment, Tenure and Promotion Committee, College of Veterinary Medicine, Oklahoma State University, 2005-2007.

Member, Veterinary Administrative Council, College of Veterinary Medicine, Oklahoma State University, 2005-2012.

Interim Member, Council of Associate Deans for Research, OSU. 9/06-5/07.

Ex Officio Member, Research Advisory Committee, OSU-CVHS. 9/06-5/07.

Member, Search Committee for Dean, OSU Center for Veterinary Health Sciences, October 2010-2011.

Member, Regents Professor Selection Committee, OSU, April, 2011.

Member, Research Advisory Committee, 2012-present.

Chair, Departmental Personnel Committee, 2013-2014.

Member, Task Force to review OSU Procedures to Govern Overload Assignments, Outside Professional Activities, and Other Outside Activities of Faculty Members, 2013.

Member, Search committee, Director of Continuing Education, CVHS, OSU (2013).

Member, Regents Professor Selection Committee, OSU, March-April, 2013.

Member, Search Committee, Physiological Sciences Department Head, CVHS (2013-2014).

Head, Search Committee, Physiological Sciences Department Head, CVHS (2014).

Member, Search Committee, Pathobiology Department Head, CVHS (2014-2015).

Chair, CVHS Tenure and Promotion Committee (2014-2017).

Member, Search Committee for OSU Vice President for Research (2014-2015).

Member, Research Purchasing, Oklahoma State University (2015-2016).

Member, Search Committee for Associate Dean for Graduate Studies, Oklahoma State University (2017).

52 OTHER ACTIVITIES

Instituted the Endowed Lecture Program at Oklahoma State University, the Sitlington Lecture in Toxicology. This program brings renowned scientists to our campus to highlight toxicology research. Sitlington lecturers include Toshio Narahashi (2000), Dave Eaton (2001), Ernest Hodgson (2002), Peter Spencer (2003), Kenneth Olden (2004), Dave Dorman (2005), Ken Wallace (2006), David Warheit (2007), Michael Aschner (2008), Bill Slikker (2009), Stephanie Padilla (2010), Donald Fox (2011), Steve Klaine (2012), Pam Lein (2014), Robert Tanguay (2015), Peter Goering (2016), Kevin Crofton (2017), Marion Ehrich (2018), James Klaunig (2019).

Patent

Dormer, K., Po, S., Scherlag, B. and Pope, C. Magnetically-targeted treatment for cardiac disorders. Patent # 8740872.

Private Pilot, Certificate #3074390, June, 2005.