United States Patent (19) (11) 4,354,029 Kaiser Et Al
United States Patent (19) (11) 4,354,029 Kaiser et al. 45) Oct. 12, 1982 54) PREPARATION OF (56) References Cited 2-SUBSTITUTED-2-OXAZOLINES WITH ORGANIC ZINC SALT CATALYSTs U.S. PATENT DOCUMENTS 3,813,378, 5/1974 Whitte et al........................ 548/239 (75) Inventors: Mark E. Kaiser, Midland, Mich.; 3,917,631 11/1975 Arlt..................................... 548/239 David L. Larson, Cookeville, Tenn. 4,014,880, 3/1977, Dowd et al. ........................ 548/239 (73) Assignee: The Dow Chemical Company, 4,035,309 7/1977 Brois ................................... 548/239 Midland, Mich. FOREIGN PATENT DOCUMENTS (21) Appl. No.: 325,948 1483682 8/1977 United Kingdom . 22) Filed: Nov.30, 1981 Primary Examiner-Anton H. Sutto Related U.S. Application Data Attorney, Agent, or Firm-Charles J. Enright (6) Continuation of Ser. No. 966,696, Dec. 5, 1978, aban 57 ABSTRACT doned, which is a continuation-in-part of Ser. No. 2-Substituted-2-oxazolines are prepared by contacting 758,279, Jan. 10, 1977, abandoned, and Ser. No. N-(2-hydroxyalkyl)carboxamides with a small but cata 875,280, Feb. 6, 1978, abandoned. lytic amount of an organic zinc salt at an elevated tem (51) Int. Cl... CO7D 263/12 perature. (52) U.S.C. ........... (58). Field of Search......................................... 548/239. 8 Claims, No Drawings 4,354,029 1 2 . PREPARATION OF. SUMMARY OF THE INVENTION 2-SUBSTITUTED-2-OXAZOLNES WITH A new process for making 2-substituted-2-oxazolines ORGANICZNC SALT CATALYSTS has now been discovered. The new process comprises reacting by contacting in a liquid phase an N-(2-hydrox CROSS-REFERENCE TO RELATED yalkyl)carboxamide with a small but catalytic amount APPLICATIONS of an organic zinc salt.
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