Mice Deficient in the Respiratory Chain Gene Cox6a2 Are Protected Against High-Fat Diet-Induced Obesity and Insulin Resistance
Mice Deficient in the Respiratory Chain Gene Cox6a2 Are Protected against High-Fat Diet-Induced Obesity and Insulin Resistance Roel Quintens1¤a, Sarvjeet Singh2, Katleen Lemaire1, Katrien De Bock3,4, Mikaela Granvik1, Anica Schraenen1, Irene Olga Cornelia Maria Vroegrijk5, Veronica Costa6, Pieter Van Noten7, Dennis Lambrechts8, Stefan Lehnert1, Leentje Van Lommel1, Lieven Thorrez1¤b, Geoffroy De Faudeur1, Johannes Anthonius Romijn5, John Michael Shelton2, Luca Scorrano6, Henri Roger Lijnen9, Peter Jacobus Voshol5, Peter Carmeliet3,4, Pradeep Puthenveetil Abraham Mammen2, Frans Schuit1* 1 Gene Expression Unit, Department of Molecular and Cellular Medicine, Katholieke Universiteit Leuven, Leuven, Belgium, 2 Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, 3 Vesalius Research Center, Katholieke Universiteit Leuven, Leuven, Belgium, 4 Vesalius Research Center, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium, 5 Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands, 6 Department of Cell Physiology and Metabolism, University of Geneva, Geneve, Switzerland, 7 Physical Activity and Health Laboratory, Biomedical Kinesiology Department, Katholieke Universiteit Leuven, Leuven, Belgium, 8 Department of Metallurgy and Materials Engineering, KU Leuven, Leuven, Belgium, 9 Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium Abstract Oxidative phosphorylation in mitochondria is responsible for 90% of ATP synthesis in most cells. This essential housekeeping function is mediated by nuclear and mitochondrial genes encoding subunits of complex I to V of the respiratory chain. Although complex IV is the best studied of these complexes, the exact function of the striated muscle- specific subunit COX6A2 is still poorly understood. In this study, we show that Cox6a2-deficient mice are protected against high-fat diet-induced obesity, insulin resistance and glucose intolerance.
[Show full text]