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CV Jamal Mahajna CV Jamal Mahajna Date: December 2020 A. Personal Details Full name: Jamal Mahajna Date of birth (month/year): June 1957 Country of birth: Israel Date of immigration to Israel. N/A Citizenship: Israeli ID (or passport) number: 054799531 Family status; M+2 Full home address: Street, house number, town, postal code: 9/4 Dalia street, Nof HaGalil 1709118. Home: phone, fax, cell phone numbers: Home phone: 04-6012277; Mobile: 050- 4242634 E-mail address: [email protected]; [email protected] B. Higher Education: 1977-1980 Hebrew University in Jerusalem: B.Sc. Biology. 1980-1982 Hebrew University in Jerusalem: M. Sc. Dept. Molecular Genetics, Amos Oppenheim's Laboratory. Regulation of Lambda Gene Expression 1982-1986 Hebrew University in Jerusalem: Ph.D. Dept. Molecular Genetics, Amos Oppenheim's Laboratory. Regulation of Lambda Gene Expression Additional Education, Training and Professional Certificates 1986-1987 Postdoc 1: Biolume Ltd., Haifa, Israel. Genetic analysis of the bioluminescence system of Vibrio fischeri. 1987-1991 PostDoc 2: Oncogene Science Inc. Uniondale, New York, USA: Development of cell-based transcription screens 1997- 1998 Sabbatical leave at the Biology Department, Technion- Israeli Institute of Technology, Haifa, Israel. Hosted by Prof. Gera Nufeild, Technion, Haifa , Israel. 1 C. Academic Appointments and Academic Administrative Positions in Institutions of Higher Education: Appointments at academic institutions 1998-2000 Research Investigator at the Regional R&D Center-The Galilee Society, Shefa-Amr, Israel. 2001-2002 Scientific Director of the R&D Regional Center-The Galilee Society, Shefa-Amr, Israel. 2002-present Research Investigator and Department Head of Cancer Drug Discovery program, MIGAL, Kiryat Shmona, Israel. 2005-2009 Lecturer at Tel-Hai College, the Department of Biotechnology, Kiryat Shmona, Israel. 2010-2016 Senior Lecturer at Tel-Hai College, the Department of Biotechnology, Kiryat Shmona, Israel. 2011-2016 Head of the Nutritional Sciences Department, Tel Hai College, Kiryat Shmona, Israel. 2016-present Associate Professor at Tel-Hai College, the Department of Biotechnology and Nutritional Sciences, Kiryat Shmona, Israel. October 2018 Visiting Professor at the department of Dietetics of Life Sciences University (SGGW), Warsaw, Poland Positions in Non-academic & Research Institutions 1991-1995 Oncogene Science Inc. Uniondale, New York, USA. Senior Research Scientist. Cancer Department, group leader of retinoid and angiogenesis drug discovery programs. 1995-1997 Oncogene Science Inc. Uniondale, New York, USA. Research Investigator. Cancer Department, group leader of apoptosis and tyrosine kinases drug discovery programs. 2001-2003 Chief Scientific Officer of PlasaMed, Misgav Technological Incubator. Israel 2 2005-2008 Founder and Chief Scientific Officer of MyCure, Meytav Technological Incubator, P.O.B 408, Kiryat Shmona 11013, Israel D. Teaching : Teaching at Academic Institutions 1. Biotechnology in Medical Sciences. Biotechnology Department, Tel-Hai College, Kiryat Shmona, Israel. 2. Laboratory in medical Sciences. Biotechnology Department, Tel-Hai College, Kiryat Shmona, Israel. 3. Nutrition and Cancer. Nutritional Sciences Department, Tel-Hai College, Kiryat Shmona, Israel. 4. Molecular Bases of cancer. MSC students, Biotechnology Department, Tel- Hai College, Kiryat Shmona, Israel. 5. Nutrition for Cancer Prevention. Nutritional Sciences Department, Tel-Hai College, Kiryat Shmona, Israel. 6. Molecular Nutrition. Nutritional Sciences Department, Tel-Hai College, Kiryat Shmona, Israel E. Supervision of Graduate Students: 1. Abdul Rahim Aisheh, MSC, Palestinian Medicinal Plants as Therapeutics for CML, An-Najah University, Nablus, Palestine, 1999-2001. 2. Majed Yassin, PhD, Medicinal Mushrooms As potential therapeutics for CML, Haifa University, Israel, Co-supervision with Prof. Solomon Wasser, 2002-2006. 3. Benzi Zaidman, PhD, Androgen receptor-dependent and independent mechanisms underline the anti-prostate cancer activity of Ganoderma Lucidum, Haifa University, Israel, Co-supervision with Prof. Solomon Wasser, 2003-2007. 4. Rumiana Petrovabg, PhD, Medicinal Mushroom Modulators of NF-KB activity as Potential Therapeutics for Breast Cancer, , Haifa University, Israel, Co- supervision with Prof. Solomon Wasser, 2004-2008. 5. Hila Tuvi, MSC, Medicinal Mushrooms As Inhibitors of Bcr-Abl activity as potential therapy for CML, Haifa University, Israel, Co-supervision with Prof. Solomon Wasser, 2005-2007. 6. Nili Ruimi, MSC, Mushroom Substances regulate the expression of iNOS in RAW264.7 macrophage cells, Haifa University, Israel, Co-supervision with Prof. Solomon Wasser, 2006-2008. 3 7. Einat Gochman, PhD, Modulation of tyrosine kinases activity by NF-kB induced iNOS expression, Technion-Rambam Medical School, Israel, Co-supervision with Prof. Abraham Reznick, 2007-2010. 8. Yaniv Menahim, MSC, Mushrooms that regulating NF-KB pathway in Imatinib- resistant CML, Haifa University, Israel, Co-supervision with Prof. Solomon Wasser, 2008-2010. 9. Michal Werner, MSC, Differentiation therapy to B cell lymphoma, Tel Aviv University, Israel, Co-supervision with Prof. Shai Izraeli, 2008-2010. 10. Nesli Dotan, PhD, Mushroom substances from coprinus comatus as potential therapeutics for hormone-refractory prostate cancer, Haifa University, Israel, Co-supervision with Prof. Solomon Wasser, 2007-2011 11. Mamduh Katib, MSC, MBP competitors as modulators of Abl activity, Tel Hai College, Israel, 2009-2011. 12. Ola Orgil, MSC, The levels of punicalgains, gallagic, ellagic and gallic acids in Pomegranate organs and their relation to antioxidant activity and inhibition of two cancer cells lines, Tel Hai College, Israel, Co-supervision with Prof Rachel Amir, 2010-2012. 13. Einav Ratzon, MSC, Anti-tumor activity of novel platinum (IV) complexes, Anti- tumor activity of novel platinum (IV) complexes, Tel Hai College, Israel, 2010- 2012. 14. Amir Bahat, MSC, Allosteric inhibitors for Bcr-Abl as therapeutics for CML, Tel Hai College, Israel, 2011-2013. 15. Shay Gefen Roitman, MSC, Allosteric inhibitors for Bcr-Abl as therapeutics for CML, Tel Hai College, Israel, 2012-2014. 16. Farah Reslan, MSC, Involvement of EMT process in prostate Cancer, Tel Hai College, Israel, 2013-2015. 17. Ofer Regev, MSC, Drug resistance and collateral sensitivity mediated in EMT regulators in Ph-positive leukemia, Tel Hai College, Israel, 2014-2016. 18. Meshel Nickola, MSC, Elucidation the mechanism of action of Crizotinib as an Abl allosteric inhibitor, Tel Hai College, Israel, 2014-2016. 19. Noa Kidan, MSC, Involvement of catenin in bone marrow homing and disease progression of Ph positive leukemia, Tel Hai College, Israel, 2014-2016. 20. Lena Avinery ,MSC, Tel Hai College, Israel, 2015-present. 21. Tamir lev , MSC, Tel Hai College, Israel, 2015-present. 4 22. Nimas Naser, MSC, Tel Hai College, Israel, 2016-present. 23. Rina Adawi, MSC, Tel Hai College, Israel, 2016-present. 24. Hatem Mahmud, MSC, Tel Hai College, Israel 2017-present 25. Yoni Dalali, MD, Joint supervision with Dr. Inbal Dahan, Bar-Ilan Medical School, Israel 2018-2019. 26. Yifat Carmi, PhD student, Ben-Gurion University, Israel, co-supervision with Prof. Jacob Gopas 2018-present. 27. Orr Shahar, MSC, Tel-Hai College, Israel 2019-present 28. Sabrin Nafahh, MSC, Tel hai College, Israel 2020-present 29. Katty Hana, , MSC, Tel hai College, Israel 2021-present F. Research Grants 1. The Middle East Cancer Consortium (MECC) , Medicinal plants as a source of therapeutics for the treatment of hormone-refractory prostate cancer, collaboration with Prof. M.S. Shtayeh, An-Najah University, amount of 30,000$, 1999-2000, Publication #9. 2. Israel Ministry of Science, Natural Products As inhibitors of VEGFR, amount of 60,000$, 1999-2001. 3. Israel Ministry of Science, Medicinal Mushrooms As modulators of BCR/ABL, amount of 60,000$, 2000-2002 4. The Middle East Cancer Consortium (MECC), Synthesis and activity of novel tyrosine kinase inhibitors, amount of 30,000$, 2000-2002. 5. ICRF, Natural Products to overcome Imatinib-refractory CML, amount of 30,000$, 2002-2004. 6. Israel Ministry of Science, Botanical steroids as potential prostate cancer therapeutics, , amount of 60,000$, 2004-2006. 7. Israel Ministry of Science, Mushroom Substances As anticancer Agents, amount of 60,000$, 2005-2007. 8. Israel Ministry of Science, Natural products as modulators of NFKB activity to improve HSVtk-based cancer gene therapy Mushroom Substances As anticancer Agents, amount of 60,000$, 2005-2008 9. Israeli-Palestinian Science Foundation (IPSO), Targeting the Myristoyl Binding Pocket (MBP) in Bcr-Abl: A Rational Approach for the Design of Therapeutics 5 Against Philadelphia Chromosome, collaboration with Dr. Yousef Najajreh, Al-Quds University, Prof. Amiram Goldblum, Hebrew University, amount of 30,000$, 2006-2008. Publication #33. 10. Israel Ministry of Science, Overcoming acquired resistance in molecular therapy: inhibition of alternative pathways in Gleevec-refractory CML, amount of 60,000$, 2007-2010. Publication #26, #33. 11. DFG (Trilateral Palestinian-Israel-German Project), Targeting the Myristoyl Binding Pocket (MBP) in Bcr-Abl: A Rational Approach for the Design of Therapeutics Against Philadelphia Chromosome, collaboration with Dr. Yousef Najajreh, Al-Quds University, Prof. Amiram Goldblum, Hebrew University, Prof. Martin Ruthardt, Goethe University, amount of 125,000 Euro, 2007-2013, Publications #31, #35, #37, #38, #39. 12. Israel Cancer Association, Risk assessment of herb-chemotherapy
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