Thèse Coccidiose Du Poulet

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Thèse Coccidiose Du Poulet اجلمهورية اجلزائرية الدميقراطية الشعبية République Algérienne Démocratique et Populaire وزارة التعليم العايل والبحث العلمي Ministère de l’Enseignement Supérieur et de la Recherche Scientifique Université Constantine 1 جامعة قسنطينة Institut des Sciences Vétérinaires 1 معهد العلوم البيطرية Thèse Présentée en vue de l’obtention du Doctorat en Sciences Vétérinaires Option : Pathologie aviaire Coccidiose du poulet : Etude pharmacologique et immunologique Présentée Par : DJEMAI Samir Membres du jury : Gamma 횪 휸 Omicron 횶 흄 Président BENCHEIKH ELFEGOUN Professeur Université de Constantine Mohammed Chérif Examinateur BENAKHLA Ahmed Professeur Université d’El-Tarf Examinateur AISSI Meriem Professeur École Nationale Supérieure Vétérinaire- Alger Examinateur ALLOUI Nadir Professeur Université de Batna Directeur de thèse MEKROUD Abdeslam Professeur Université de Constantine Année universitaire : 2016 / 2017 قَا َل َر ُسو َل ا ه َِّلل َص هَّل ا ه َُّلل عَلَْي ِه َو َس هَّل :« اللههُ هم انْ َف ْعِِن ِب َما عَله ْمتَِِن، َوعَِل ْمِِن َما يَْن َف ُعِِن، َوا ْرُز ْقِِن ِعلْ ًما تَ ْن َف ُعِِن ِب ِه » . ]السلسةل الصحيحة-حديث رمق 3151- ا أللباين[. Le Prophète- Que la prière d'Allah et Son salut soient sur lui- disait : « Ô Allah ! Fais- moi profiter de ce que Tu m’as appris, Apprends-moi ce qui m’apporte bénéfice et Accorde-moi une science par laquelle Tu Vas me faire profiter ». [Silsila Sahiha n°3151-Cheikh Al-Albani]. Prophet Muhammad-Peace be upon him- said : « Oh Allah ! Make useful for me what you have taught me, (and) teach me knowledge that will be useful to me and grant me such knowledge that will benefit me ». [Silsila Sahiha n°3151-Cheikh Al-Albani]. I Remerciements A Monsieur le Professeur Mohamed Chérif BENCHEIKH ELFEGOUN, de l’Institut des Sciences Vétérinaires-Université Mentouri de Constantine, Qui nous a fait le grand honneur d’accepter la présidence de notre jury de thèse. Hommages respectueux. A Monsieur le Professeur Abdeslam MEKROUD, de l’Institut des Sciences Vétérinaires- Université Mentouri de Constantine, Pour avoir accepté d’être le directeur de thèse, pour l’attention qu’il a portée à la réalisation de ce travail, pour ses grandes idées et ses si précieux conseils, pour le temps qu’il a consacré à la correction et l’orientation de ce travail. Qu’il trouve ici l’expression de notre gratitude. A Monsieur le Professeur Ahmed BENAKHLA, de l’Université d’El-Tarf, Qui a accepté de participer à notre jury de thèse. Sincères remerciements. A Madame le Professeur Meriem AISSI, de l’Ecole Nationale Supérieure Vétérinaire d’Alger, Qui a accepté d’être membre de notre jury de thèse. Veuillez trouver ici l’hommage de notre profond respect et nos sincères remerciements. A Monsieur le Professeur Nadir ALLOUI, de l’Université de Batna, Pour avoir accepté de prendre part à ce jury de thèse. Nos respects les plus sincères. A Monsieur le Professeur El Hacene BERERHI , Directeur de l’Institut des Sciences Vétérinaires-Université Mentouri de Constantine, Pour m’avoir toujours soutenu dans ma tâche pédagogique, pour son aide si précieuse et sans faille, ce qui m’a permis d’effectuer des stages au Royaume-Uni. Témoignage de ma sincère reconnaissance et de mon profond respect. A Monsieur le Professeur Geoff HIDE, de l’Université de Salford-Manchester UK, Pour sa patience, sa disponibilité et tout le temps accordé pour la réalisation de l’identification moléculaire des coccidies de poulet présentes dans nos prélèvements et ce, dans le but de performer ce travail. Très sincère reconnaissance. A Monsieur le Professeur Mark JENKINS, de l’Animal Parasitic Diseases Laboratory of Agricultural Research Service-USDA, Pour sa collaboration dans la réalisation du premier volet de ce travail, pour ses idées si précieuses dans la compréhension de l’atténuation des Eimeria spp par les agents physiques. Très sincères remerciements. II A Mesdames les Docteurs FAFA et BELGHIAT, du Laboratoire d’Hygiène-Jijel, Pour leur assistance dans la réalisation et la lecture des coupes histologiques effectuées dans le premier volet de l’étude. Hommage de mon profond respect. A Messieurs Brahim DJEMAI et Mohammed DJEMAI, Pour leur assistance inestimable dans la rédaction de cette thèse et des articles y afférents. Qu’ils trouvent ici l’expression de toute ma gratitude. A Madame le Docteur Manal MEHIBEL et Monsieur le Docteur Samih MEHIBEL, Pour leur aide inappréciable et le soutien qu’ils m’ont toujours donné. Je remercie chaleureusement tous les membres du laboratoire « P.A.D.E.S.C.A » : Dr Amir Agabou, Dr Aimer Fayçal, Dr Mohammed Chérif Abdeldjalil, Dr Baghoul Saber, Dr Chebira Bacem, Dr Beroual Katiba et bien d’autres. III Acknowledgment I would like to thank my committee chair, Professor. Mohamed Chérif BENCHEIKH ELFEGOUN, from the Institute of Veterinary Sciences- Constantine University, who has given us the great honor for accepting our thesis jury presidency. A special thanks goes to my supervisor, Professor. Abdeslam MEKROUD, from the Institute of Veterinary Sciences- University of Constantine, for his big support and advice throughout these five years. I would also like to thank the other members of the jury : • Professor. Ahmed BENAKHLA, from the University of ElTarf-Algeria. • Professor Meriem AISSI, from « Ecole Nationale Supérieure Vétérinaire » of Algiers- Algeria. • Professor Nadir ALLOUI, from the University of Batna- Algeria. All my sincere feeling of gratitude to Professor. El Hacene BERERHI, Director of the Institute of Veterinary Sciences- University of Constantine, for having always supported me in my teaching task, for his precious and flawless help that enables to carried out the training course in the University of Salford-UK. My special gratitude goes to Professor. Geoff HIDE, from the University of Salford-UK, for his patience, his availability and all his time granted to realize the molecular identification of the coccidia of chicken present in our samples , in order to perform this work. I would like to thank Professor. Mark JENKINS, from the Animal Parasitic Diseases Laboratory of Agricultural Research Service-USDA, for his collaboration in the realization of the first part of this work. Thanks also to Dr. FAFA and Dr. BELGHIAT, from the « Laboratoire d’Hygiène-Jijel- Algeria », for their help in carrying out the histological sections made in the first study. I warmly thank Mr. Brahim DJEMAI and Mr. Mohammed DJEMAI, for their invaluable assistance in writing this thesis and corresponding scientific paper. I want to also express my warmest thanks to Dr Manal MEHIBEL, from the University of Manchester-UK, and the Veterinary Doctor Samih MEHIBEL, for their invaluable help and support they have always given me. I thank all the members of the laboratory « P.A.D.E.S.C.A »: Dr Amir Agabou, Dr Aimer Fayçal, Dr Mohammed Chérif Abdeldjalil, Dr Baghoul Saber, Dr Chebira Bacem, Dr Beroual Katiba. IV Je dédie ce travail A mes très chères parents … Maman, femme vigoureuse des plus puissantes, symbole d’abnégation et de dévouement, … Papa, homme de sagesse des plus nobles, emblème de raison et de clairvoyance… pour leur soutien et leur assistance, pour l’exigence qu’ils ont eu envers moi, pour m’avoir toujours incité à donner le meilleur de moi-même, … que ce travail soit la preuve de l’éducation juste qu’ils m’ont offerte … espérant qu’ils soient fiers de moi, je leur adresse tous mes sentiments d’amour et de reconnaissance… Puisse Allah, le Tout- Puissant, vous préserver et vous accorder santé, longue vie et bonheur. A mon épouse Sihem, symbole de douceur et d’affection … pour ses sacrifices, son soutien moral, sa gentillesse, son profond attachement et sa patience sans égal … qu’elle trouve ici mon témoignage d’amour sincère et de respect … Qu’Allah unisse nos chemins jusqu’à terme de nos vies. A ma puce Yamina (Fatima) et mon brave Ibrahim qui ont agrémenté, agrémentent et agrémenteront, inchallah, toujours ma vie... pour être là, tout simplement ; sans vous, louange à Allah, la vie n’aurait aucune saveur. A mon frère ainé Mohammed, mon ange gardien et mon compagnon dans les moments les plus durs de la vie… A son épouse Zohra et à leurs petites filles ; la charmante Maram et l’adorable Chahla (Chichi) … Qu’ils trouvent ici mes meilleurs vœux de bonheur, de santé et de réussite. A Naouel, ma sœur unique, bijou et perle de notre famille … et à son fils le vaillant Mouatez (Zizou)… Qu’Allah vous accorde une longue vie pleine de succès et de quiétude. A mon frère cadet Daoud, personne généreuse des meilleures, serviable des plus complaisants… A son épouse Soumia… Qu’ils daignent accepter mes sentiments d’affection et de considération. A mes amis intimes et mes fidèles compagnons Sami et Toufik… pour leur soutien et leur aide sans faille pendant toute ces longues années … Tous mes sentiments de gratitude et de reconnaissance. A mes oncles et tantes … Hamou, Moussa, Nacer, Mohammed, Mokhtar, Seddik, Rachid (Abbad), Rachid (Hammada), Mahfoud, Zoubida, Rachida, Saliha, Khadidja, Wahiba, Souad… et à tous les membres de leurs familles… je vous aime tous. A mon beau-père Ammar et mon beau-frère Boualem, ainsi que toute leur famille… Qu’ils trouvent ici l’expression de mes sentiments respectueux. A tous mes cousins et cousines… Nabil, Adel, Amine, Mouloud, Aissa, Taher, Yahya, Bilel, Abdou, Houcine, Nadjwa, Zoulikha, Feriel, Fadia, Habiba, Katima, Widad, Lydia, Warda, et bien d’autres … Je souhaite à tous une très bonne continuité dans la vie. A ma défunte cousine Laila… Qu’Allah Lui Accorde Sa Miséricorde et l’Accueille en Son vaste paradis. V A mes amis d’enfance Samih, Mounir, Lyes, Khaled, Laid, Karim, Latif, Riad, Rabeh, Omar, Antar, Ahmed, Atman, Fares, Raouf, Samir, Bader, Boualem, Bachir et bien d’autres… pour leur amitié si précieuse et tous les bons moments passés et à venir.
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