High-resolution PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Miconia albicans Lima, Rita de Cassia Lemos; Kongstad, Kenneth Thermann; Kato, Lucília; José das Silva, Marcos; Franzyk, Henrik; Stærk, Dan Published in: Molecules DOI: 10.3390/molecules23071755 Publication date: 2018 Document license: CC BY Citation for published version (APA): Lima, R. D. C. L., Kongstad, K. T., Kato, L., José das Silva, M., Franzyk, H., & Stærk, D. (2018). High-resolution PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Miconia albicans. Molecules, 23(7), [1755]. https://doi.org/10.3390/molecules23071755 Download date: 24. Sep. 2021 molecules Article High-Resolution PTP1B Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of PTP1B Inhibitors from Miconia albicans Rita de Cássia Lemos Lima 1 ID , Kenneth T. Kongstad 1 ID , Lucília Kato 2, Marcos José das Silva 3, Henrik Franzyk 1 ID and Dan Staerk 1,* ID 1 Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark;
[email protected] (R.d.C.L.L.);
[email protected] (K.T.K.);
[email protected] (H.F.) 2 Instituto de Química, Universidade Federal de Goiás, Goiânia 70040-010, Brazil;
[email protected] 3 Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia 70040-010, Brazil;
[email protected] * Correspondence:
[email protected]; Tel.: +45-3533-6177 Received: 14 June 2018; Accepted: 12 July 2018; Published: 17 July 2018 Abstract: Protein tyrosine phosphatase 1B (PTP1B) is an intracellular enzyme responsible for deactivation of the insulin receptor, and consequently acts as a negative regulator of insulin signal transduction.