DOCSLIB.ORG

Advances in the Knowledge of Olive Oil Phenolic Compounds. from Biotransformations After Their Intake to Their Metabolic Fate for Exerting Biological Activities

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Advances in the Knowledge of Olive Oil Phenolic Compounds. from Biotransformations After Their Intake to Their Metabolic Fate for Exerting Biological Activities Nom/Logotip de la Universitat on s’ha llegit la tesi Advances in the knowledge of olive oil phenolic compounds. From biotransformations after their intake to their metabolic fate for exerting biological activities Maria del Carmen López de las Hazas Mingo http://hdl.handle.net/10803/402402 ADVERTIMENT. L'accés als continguts d'aquesta tesi doctoral i la seva utilització ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, així com en activitats o materials d'investigació i docència en els termes establerts a l'art. 32 del Text Refós de la Llei de Propietat Intel·lectual (RDL 1/1996). Per altres utilitzacions es requereix l'autorització prèvia i expressa de la persona autora. En qualsevol cas, en la utilització dels seus continguts caldrà indicar de forma clara el nom i cognoms de la persona autora i el títol de la tesi doctoral. No s'autoritza la seva reproducció o altres formes d'explotació efectuades amb finalitats de lucre ni la seva comunicació pública des d'un lloc aliè al servei TDX. Tampoc s'autoritza la presentació del seu contingut en una finestra o marc aliè a TDX (framing). Aquesta reserva de drets afecta tant als continguts de la tesi com als seus resums i índexs. ADVERTENCIA. El acceso a los contenidos de esta tesis doctoral y su utilización debe respetar los derechos de la persona autora. Puede ser utilizada para consulta o estudio personal, así como en actividades o materiales de investigación y docencia en los términos establecidos en el art. 32 del Texto Refundido de la Ley de Propiedad Intelectual (RDL 1/1996). Para otros usos se requiere la autorización previa y expresa de la persona autora. En cualquier caso, en la utilización de sus contenidos se deberá indicar de forma clara el nombre y apellidos de la persona autora y el título de la tesis doctoral. No se autoriza su reproducción u otras formas de explotación efectuadas con fines lucrativos ni su comunicación pública desde un sitio ajeno al servicio TDR. Tampoco se autoriza la presentación de su contenido en una ventana o marco ajeno a TDR (framing). Esta reserva de derechos afecta tanto al contenido de la tesis como a sus resúmenes e índices. WARNING. Access to the contents of this doctoral thesis and its use must respect the rights of the author. It can be used for reference or private study, as well as research and learning activities or materials in the terms established by the 32nd article of the Spanish Consolidated Copyright Act (RDL 1/1996). Express and previous authorization of the author is required for any other uses. In any case, when using its content, full name of the author and title of the thesis must be clearly indicated. Reproduction or other forms of for profit use or public communication from outside TDX service is not allowed. Presentation of its content in a window or frame external to TDX (framing) is not authorized either. These rights affect both the content of the thesis and its abstracts and indexes. TESI DOCTORAL Advances in the knowledge of olive oil phenolic compounds. From biotransformations after their intake to their metabolic fate for exerting biological activities Maria del Carmen López de las Hazas Mingo Memòria presentada per optar al grau de Doctor per la Universitat de Lleida Programa de Doctorat en Ciencia i tecnologia agrària i Agroalimentària Director/a Maria José Motilva Casado Tutor/a Carme Piñol Felis 2017 Doctoral Thesis presented by Maria del Carmen López de las Hazas Mingo to obtain a PhD degree from the University of Lleida. This Doctoral Thesis was supervised by María José Motilva Casado and Carme Piñol Felis. The present work was carried out in the Department of Food Technology’s Antioxidants Research Group and comes under the “Agricultural and Food Science and Technology” doctoral programme. This Doctoral Thesis is framed within the context of two different projects: The MEFOPC project: Metabolic fate of olive oil phenolic compounds in humans: Study of metabolic pathways and tissue distribution (Ref. AGL2012- 40144-C03-03). The INCOMES project: Guide for the substantiation of health claims in foods: Immune, cognitive functions and metabolic syndrome (Collaborative project between Food Companies & Research Centres). The PhD candidate received a doctoral grant from the University of Lleida (November 2013 – October 2016) and an internship grant from the University of Lleida. The Language Institute at the University of Lleida awarded a grant (2017 call) for the language revision of this Doctoral Thesis. PhD Candidate Maria del Carmen López de las Hazas Mingo Supervisor María José Motilva Casado, PhD Signature of approval Co-supervisor Carme Piñol Felis, PhD Signature of approval I want to try everything I want to try even though I could fail I won't give up, no I won't give in Till I reach the end and then I'll start again Sia Furler ACKNOWLEDGMENTS "Que tu medicina sea tu alimento, y el alimento tu medicina." La frase que despertó mi motivación por la ciencia, y con el paso del tiempo ha ido forjando mi camino. Ahora que se acaba esta etapa, puedo decir que he sido muy afortunada porque he contado con el mejor apoyo, tanto que resulta difícil resumir en pocas líneas la gratitud que siento. En primer lugar, me gustaría agradecer a la Dra. María José Motilva el haberme brindado la oportunidad de haber realizado la tesis en el grupo de Antioxidants. Gracias por todo tu esfuerzo y trabajo dedicado, agradezco muchísimo todos los consejos, tu guía y disponibilidad bañada de tanta cercanía, ha sido una suerte tenerte. Gracias por contagiarme de tu pasión por la ciencia. Gracias a la Dra. Carme Piñol tu atención, confianza y todas las facilidades que me has dado para que las tareas del estabulario fuesen más sencillas. Gracias a todo Antioxidant’s lab team! Alba… No tinc palaures per descriure la teva aportació a la tesi. Merci per tota la teva ajuda! Has sido la pieza clave para el desarrollo de la tesis, compartir momentos tan buenos y ser la mejor maestra de Catalán del mundo!. Laura, ¡la mamá de esta tesis! no solo porque ésta continúa el camino que abriste con la tuya, sino porque no has faltado de estar ahí ni un minuto como guía y ayuda ¡¡¡GRACIAS!!!; Iziar, ¡ha sido un gustazo compartir laboratorio y experimentos contigo! Muchas gracias por tu cercanía, compartir tu sabiduría y tus millones de consejos; David, gracias ¡por tantos momentos de estabulario y laboratorio! Ha sido fantástico ¡Animo con la tesis!; MªPaz, muchísimas gracias por toda tu ayuda y soporte en el laboratorio, por dejarlo todo para ayudarme con las ASE averías! Además has sido la maestra que nos permitió crear nuestra propia cerveza artesana! (Mospez & Tremoló)… mi Juana, mi socia cervecera… porque hemos compartido miles de horas y recorrido juntas un largo camino y siempre has estado ahí para ayudarme, escucharme y aconsejarme, por todo lo que he crecido a tu lado, por tantos momentos dentro y fuera del laboratorio ¡¡¡Cuánto te echo de menos!!!. Gracias a la tropa Chimichurris, por ser mis lab mates y mi familia lleidatá, ¡Cuántos momentos imborrables regados con cervecitas y alimentados con pizzas, nachos y queso! Gracias en especial a Laila, que bueno haber compartido otros 3 años de camino juntas, ahora el destino ¿nos llevará de la mano? O esta vez nos llevará por otro lado? Lo bueno, es que todos estos años han sido una fuente magnifica de buenos momentos ¡¡Que sigan siendo!!; Joana, me siento orgullosa de conocer a una persona tan generosa y admirable, ¡¡gracias por tantos consejos!! ;) Y Sandra, mi dedo gatillo, por enseñarme a vivir de otra manera, ser tan buena compañera de aventuras y mejor amiga. Gracias a todas personas que forman y formaron parte del departamento de TECAL, gracias por el día a día, por inmunerables risas a la hora de la comida, en especial a Manel… ¡¡¡San Manel!!!¡el Mago que arregla desde un roto hasta un descosido! Y Montse y Jordi, porque sobran las palabras ¡¡Mil gracias por todo vuestro apoyo!! Gracias a toda la gente simpática con la que he coincidido en el IRB en especial a Ana por toda su ayuda con la histología. Gracias a todo el Reus Team! Ursula, Sara, Laura y Rosa, ha sido un placer trabajar con vosotras, gracias por vuestra ayuda, cercanía e introducirme en el mundo mecanismos. I would especially like to thank Claudia Nunes do Santos and all the members of the Molecular Nutrition and Health Laboratory at the Instituto de Biologia Experimental e Tecnológica and Instituto de Tecnologia Química e Biológica (ITQB/UNL) for their warm welcome during my 3-month intership. Thanks so much! I’m so gratefull and I’ll never forget these months with you! Thanks for all the good moments both inside and outside the lab! I miss you so much!!! Gracias a Miri, Amparo y la familia gatuna Sheera, Pepper y… Manolo! Han sido 3 años mágicos de convivencia! Gracias por todos esos momentos hogareños tan fabulosos. A mis amigas, las de siempre, con las que “se me cayeron los dientes” y he compartido tantos momentos. Espero seguir aprendiendo a vivir año tras año con vosotras ¡total… son 25 años compartidos ya! Vamos de cabeza a por los 50!;) A su vez, gracias a todos los que se incorporaron en el camino, “albucheños por el mundo”¡¡gracias familia!! por vuestra comprensión y apoyo, pese a que la distancia nos separe, mi corazón siempre recibe la energía positiva que irradiáis. Gracias a todos los compañeros que tuve en el CIAL, en especial a Juanan, quien me enseñó a caminar científicamente hablando, gracias por despertar una de mis grandes pasiones, y por tantos momentos imborrables.
Load more

Recommended publications
  • Polyphenols in Cancer Prevention: New Insights (Review)
    INTERNATIONAL JOURNAL OF FUNCTIONAL NUTRITION 1: 9, 2020 Polyphenols in cancer prevention: New insights (Review) GIUSI BRIGUGLIO1, CHIARA COSTA2, MANUELA POLLICINO1, FEDERICA GIAMBÒ1, STEFANIA CATANIA1 and CONCETTINA FENGA1 1Department of Biomedical and Dental Sciences and Morpho‑functional Imaging, Occupational Medicine Section, and 2Department of Clinical and Experimental Medicine, University of Messina, I‑98125 Messina, Italy Received July 30, 2020; Accepted September 21, 2020 DOI:10.3892/ijfn.2020.9 Abstract. A huge volume of literature data suggests that a diet Contents rich in fruits and vegetables, mostly due to the contribution of natural polyphenols, could reduce the incidence of specific 1. Introduction cancers. Resveratrol, epigallocatechin gallate and curcumin 2. Literature search are among the most extensively studied polyphenols: The 3. Classification of polyphenols majority of the effects attributed to these compounds are 4. Prostate cancer linked to their antioxidant and anti‑inflammatory properties. 5. Colon cancer The multiple mechanisms involved include the modulation 6. Breast cancer of molecular events and signaling pathways associated with 7. Lung cancer cell survival, proliferation, differentiation, migration, angio‑ 8. Bladder cancer genesis, hormonal activities, detoxification enzymes and 9. Skin cancer immune responses. Notwithstanding their promising role in 10. Pancreatic cancer cancer prevention and treatment, polyphenols often have a 11. Leukemia poor bioavailability when administered as pure active prin‑
    [Show full text]
  • Ginsenoside Rh1 Induces MCF-7 Cell Apoptosis and Autophagic Cell Death Through ROS-Mediated Akt Signaling
    cancers Article Ginsenoside Rh1 Induces MCF-7 Cell Apoptosis and Autophagic Cell Death through ROS-Mediated Akt Signaling Diem Thi Ngoc Huynh 1,2, Yujin Jin 1, Chang-Seon Myung 1 and Kyung-Sun Heo 1,* 1 College of Pharmacy, Chungnam National University, Daejeon 34134, Korea; [email protected] (D.T.N.H.); [email protected] (Y.J.); [email protected] (C.-S.M.) 2 Department of Pharmacy, Da Nang University of Medical Technology and Pharmacy, Da Nang 550000, Vietnam * Correspondence: [email protected]; Tel.: +82-42-821-5927 Simple Summary: Breast cancer (BC) is the most common cause of cancer-related deaths among women worldwide, and its incidence has been increasing. However, current therapeutic approaches, such as chemotherapy, radiation, and hormonal therapy, have become increasingly ineffective because of their severe adverse effects and multidrug resistance. Therefore, the discovery of new potential candidates for BC therapy is essential. Here, we investigated whether ginsenoside Rh1 exhibits anticancer effects on BC. We found that this ginsenoside effectively inhibited the growth of BC cells in both cell cultures and mice. Therefore, ginsenoside Rh1 is a promising candidate for BC treatment. Abstract: Breast cancer (BC) is the leading cause of cancer-related deaths among women worldwide. Ginsenosides exhibit anticancer activity against various cancer cells. However, the effects of gin- senoside Rh1 on BC and the underlying mechanisms remain unknown. Here, we investigated the anticancer effects of Rh1 on human BC MCF-7 and HCC1428 cells and the underlying signaling pathways. The anticancer effects of Rh1 in vitro were evaluated using sulforhodamine B (SRB), Citation: Huynh, D.T.N.; Jin, Y.; 3-(4, 5-dimethylthiazole-2-yl)-2, 5-diphenyltetrazolium bromide (MTT), clonogenic assay, propidium Myung, C.-S.; Heo, K.-S.
    [Show full text]
  • Valorisation of Olea Europaea L. Olive Leaves Through the Evaluation of Their Extracts: Antioxidant and Antimicrobial Activity
    foods Article Valorisation of Olea europaea L. Olive Leaves through the Evaluation of Their Extracts: Antioxidant and Antimicrobial Activity Mónica Sánchez-Gutiérrez 1,2,* , Isabel Bascón-Villegas 1,2 , Alejandro Rodríguez 2 , Fernando Pérez-Rodríguez 1, África Fernández-Prior 3 , Antonio Rosal 4 and Elena Carrasco 1 1 Food Science and Technology Department, Universidad de Córdoba, Darwin Building, 14014 Córdoba, Spain; [email protected] (I.B.-V.); [email protected] (F.P.-R.); [email protected] (E.C.) 2 BioPrEn Group, Chemical Engineering Department, Universidad de Córdoba, Marie-Curie Building, 14014 Córdoba, Spain; [email protected] 3 Instituto de la Grasa, Consejo Superior de Investigaciones Científicas (CSIC), Campus Universitario Pablo de Olavide, Edificio 46, Ctra. de Utrera, km. 1, 41013 Seville, Spain; [email protected] 4 Molecular Biology and Biochemical Engineering Department, Campus Universitario Pablo de Olavide, Edificio 46, Ctra. de Utrera, km. 1, 41013 Seville, Spain; [email protected] * Correspondence: [email protected] Abstract: Olea europaea L. leaves constitute a source of bioactive compounds with recognized benefits for both human health and technological purposes. In the present work, different extracts from olive leaves were obtained by the application of two extraction methods, Soxhlet and microwave-assisted extraction (MAE), and six solvents (distilled water, ethanolic and glycerol mixtures solvents). MAE Citation: Sánchez-Gutiérrez, M.; was applied under 40, 60 and 80 ◦C for 3, 6.5 and 10 min. The effect of the extraction method, solvent Bascón-Villegas, I.; Rodríguez, A.; and treatment factors (the latter in MAE) on the total phenol content (TPC), the antioxidant activity Pérez-Rodríguez, F.; Fernández-Prior, Á.; Rosal, A.; Carrasco, E.
    [Show full text]
  • Thyroid-Modulating Activities of Olive and Its Polyphenols: a Systematic Review
    nutrients Review Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review Kok-Lun Pang 1,† , Johanna Nathania Lumintang 2,† and Kok-Yong Chin 1,* 1 Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Kuala Lumpur, Malaysia; [email protected] 2 Faculty of Applied Sciences, UCSI University Kuala Lumpur Campus, Jalan Menara Gading, Taman Connaught, Cheras 56000, Kuala Lumpur, Malaysia; [email protected] * Correspondence: [email protected]; Tel.: +60-3-91459573 † These authors contributed equally to this work. Abstract: Olive oil, which is commonly used in the Mediterranean diet, is known for its health benefits related to the reduction of the risks of cancer, coronary heart disease, hypertension, and neurodegenerative disease. These unique properties are attributed to the phytochemicals with potent antioxidant activities in olive oil. Olive leaf also harbours similar bioactive compounds. Several studies have reported the effects of olive phenolics, olive oil, and leaf extract in the modulation of thyroid activities. A systematic review of the literature was conducted to identify relevant studies on the effects of olive derivatives on thyroid function. A comprehensive search was conducted in October 2020 using the PubMed, Scopus, and Web of Science databases. Cellular, animal, and human studies reporting the effects of olive derivatives, including olive phenolics, olive oil, and leaf extracts on thyroid function were considered. The literature search found 445 articles on this topic, but only nine articles were included based on the inclusion and exclusion criteria. All included articles were animal studies involving the administration of olive oil, olive leaf extract, or olive pomace residues orally.
    [Show full text]
  • Targeted and Untargeted Metabolomics to Explore the Bioavailability of the Secoiridoids from a Seed/Fruit Extract (Fraxinus Angu
    Article Targeted and Untargeted Metabolomics to Explore the Bioavailability of the Secoiridoids from a Seed/Fruit Extract (Fraxinus angustifolia Vahl) in Human Healthy Volunteers: A Preliminary Study Rocío García-Villalba 1, Francisco A. Tomás-Barberán 1, Pascale Fança-Berthon 2, Marc Roller 2, Pilar Zafrilla 3, Nicolas Issaly 4 and María-Teresa García-Conesa 1,* Received: 9 November 2015 ; Accepted: 4 December 2015 ; Published: 11 December 2015 Academic Editor: Emilie Combet 1 Research Group on Quality, Safety and Bioactivity of Plant Foods, Department Food Science and Technology, Centro de Edafología y Biología Aplicada del Segura (CEBAS)–Consejo Superior de Investigaciones Científicas (CSIC), P. O. Box 164, Campus de Espinardo, Murcia 30100, Spain; [email protected] (R.G.-V.); [email protected] (F.A.T.-B.) 2 Naturex SA, Site d’AgroParc, BP 1218, 84911 Avignon Cedex 9, France; [email protected] (P.F.-B.); [email protected] (M.R.) 3 Department of Food Technology and Nutrition, Catholic University of San Antonio, Campus de los Jerónimos, N˝ 135, Guadalupe, Murcia 30107, Spain; [email protected] 4 Naturex Spain SL, Autovia A3, Salida343, Camino de Torrent s/n, Quart de Poblet, Valencia 46930, Spain; [email protected] * Correspondence: [email protected]; Tel.: +34-968-396-276; Fax: +34-968-396-102 Abstract: The bark, seeds, fruits and leaves of the genus Fraxinus (Oleaceae) which contain a wide range of phytochemicals, mostly secoiridoid glucosides, have been widely used in folk medicine against a number of ailments, yet little is known about the metabolism and uptake of the major Fraxinus components.
    [Show full text]
  • Oleuropein Or Rutin Consumption Decreases the Spontaneous Development of Osteoarthritis in the Hartley Guinea Pig
    Osteoarthritis and Cartilage 23 (2015) 94e102 Oleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig M.-N. Horcajada y a, C. Sanchez z a, F. Membrez Scalfo y, P. Drion x, F. Comblain z, * S. Taralla k, A.-F. Donneau ¶, E.A. Offord y, Y. Henrotin z # y Nestle Research Center, Nutrition and Health Research, Vers-Chez-les-Blanc, Lausanne 26 1000, Switzerland z Bone and Cartilage Research Unit, Arthropole,^ University of Liege, Institute of Pathology, CHU Sart-Tilman, 4000 Liege, Belgium x GIGA CHU Animal Facility, University of Liege, 4000 Liege, Belgium k Artialis SA, 4000 Liege Belgium ¶ Public Health Department, University of Liege, 4000 Liege, Belgium # Department of Physical Therapy and Rehabilitation, Princess Paola Hospital, Marche-en-famenne, Belgium article info summary Article history: Objective: To assess the potential protective effects of three polyphenols oleuropein, rutin and curcumin, Received 10 February 2014 on joint ageing and osteoarthritis (OA) development. Accepted 28 August 2014 Design: Sixty 4-week-old DunkineHartley guinea pigs were randomized into four groups and received daily during 31 weeks either standard guinea pig diet (control group) or a standard guinea pig diet Keywords: enriched with oleuropein (0.025%), rutin (0.5%) or rutin/curcumin (0.5%/0.25%) association. Biomarkers Osteoarthritis of OA (Coll2-1, Coll2-1NO2, Fib3-1, Fib3-2, ARGS), as well as inflammation prostaglandin E2 (PGE2) were Phytonutrients quantified in the serum. Histological assessments of knee cartilage and synovial membrane were per- Oleuropein fi Rutin formed at week 4 ( ve young reference guinea pigs) and week 35.
    [Show full text]
  • Inhibitory Effect of Selaginellins from Selaginella
    molecules Article Inhibitory Effect of Selaginellins from Selaginella tamariscina (Beauv.) Spring against Cytochrome P450 and Uridine 50-Diphosphoglucuronosyltransferase Isoforms on Human Liver Microsomes Jae-Kyung Heo 1, Phi-Hung Nguyen 2, Won Cheol Kim 1, Nguyen Minh Phuc 1 and Kwang-Hyeon Liu 1,* 1 BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea; [email protected] (J.-K.H.); [email protected] (W.C.K.); [email protected] (N.M.P.) 2 Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi 122100, Vietnam; [email protected] * Correspondence: [email protected] or [email protected]; Tel.: +82-53-950-8567; Fax: +82-53-950-8557 Received: 2 August 2017; Accepted: 13 September 2017; Published: 21 September 2017 Abstract: Selaginella tamariscina (Beauv.) has been used for traditional herbal medicine for treatment of cancer, hepatitis, and diabetes in the Orient. Numerous bioactive compounds including alkaloids, flavonoids, lignans, and selaginellins have been identified in this medicinal plant. Among them, selaginellins having a quinone methide unit and an alkylphenol moiety have been known to possess anticancer, antidiabetic, and neuroprotective activity. Although there have been studies on the biological activities of selaginellins, their modulatory potential of cytochrome P450 (P450) and uridine 50-diphosphoglucuronosyltransferase (UGT) activities have not been previously evaluated. In this study, we investigated the drug interaction potential of two selaginellins on ten P450 isoforms (CYP1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 2J2 and 3A) and six UGT isoforms (UGT1A1, 1A3, 1A4, 1A6, 1A9 and 2B7) using human liver microsomes and liquid chromatography-tandem mass spectrometry.
    [Show full text]
  • Flavonol Glycosides and Their Distribution in the Perianths of Gladiolus×Grandiflora Cultivars
    Bull. Natl. Mus. Nat. Sci., Ser. B, 45(1), pp. 29–40, February 22, 2019 Flavonol Glycosides and their Distribution in the Perianths of Gladiolus×grandiflora Cultivars Tomoko Takemura1 and Tsukasa Iwashina2,* 1 United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Saiwai-cho, Fuchu 183–8509, Japan 2 Department of Botany, National Museum of Nature and Science, Amakubo 4–1–1, Tsukuba, Ibaraki 305–0005, Japan * E-mail: [email protected] (Received 16 October 2018; accepted 26 December 2018) Abstract Fifteen flavonol glycosides were isolated from the perianths of two Gladiolus×grandiflora cultivars “Ariake” and “Christmas” by various chromatography. Of their flavonols, eight glycosides were identified as kaempferol 3-O-sophoroside, 3-O-glucoside, 3-O-rutinoside and 3-O-glucosyl-(1→2)-rhamnoside, quercetin 3-O-rutinoside and myricetin 3-O-rutinoside, 3-O-glucoside and 3-O-rhamnoside by UV spectra, LC-MS, acid hydrolysis, 1H and 13C NMR, and TLC and HPLC comparisons with authentic samples. Other seven flavonols were characterized as kaempferol 3-O-pentosylglucoside, 3-O-rhamnosylrhamnosylglucoside and 3-O-glucosylrhamnoside, laricitrin 3-O-diglucoside, 3-O-rhamnosylglucoside and 3-O-rhamnosyl- hexoside, and syringetin 3-O-rhamnosylglucoside. Flavonol composition of the perianths of 89 Gladiolus×grandiflora cultivars including 12 purple, 13 reddish purple, 13 pink, 19 red, 2 orange, 16 white, 11 yellow and 3 green flower cultivars was surveyed by HPLC. Moreover, correlation between flower colors and flavonol
    [Show full text]
  • Bioconversion Using Lactic Acid Bacteria: Ginsenosides, GABA, and Phenolic Compounds Na-Kyoung Lee1 and Hyun-Dong Paik1,2*
    J. Microbiol. Biotechnol. (2017), 27(5), 869–877 https://doi.org/10.4014/jmb.1612.12005 Research Article Review jmb Bioconversion Using Lactic Acid Bacteria: Ginsenosides, GABA, and Phenolic Compounds Na-Kyoung Lee1 and Hyun-Dong Paik1,2* 1Department of Food Science and Biotechnology of Animal Resources, 2Bio/Molecular Informatics Center, Konkuk University, Seoul 05029, Republic of Korea Received: December 14, 2016 Revised: February 24, 2017 Lactic acid bacteria (LAB) are used as fermentation starters in vegetable and dairy products Accepted: March 15, 2017 and influence the pH and flavors of foods. For many centuries, LAB have been used to manufacture fermented foods; therefore, they are generally regarded as safe. LAB produce various substances, such as lactic acid, β-glucosidase, and β-galactosidase, making them First published online useful as fermentation starters. Existing functional substances have been assessed as March 15, 2017 fermentation substrates for better component bioavailability or other functions. Representative *Corresponding author materials that were bioconverted using LAB have been reported and include minor Phone: +82-2-2049-6011; ginsenosides, γ-aminobutyric acid, equol, aglycones, bioactive isoflavones, genistein, and Fax: +82-2-455-3082; daidzein, among others. Fermentation mainly involves polyphenol and polysaccharide E-mail: [email protected] substrates and is conducted using bacterial strains such as Streptococcus thermophilus, Lactobacillus plantarum, and Bifidobacterium sp. In this review, we summarize recent studies of pISSN 1017-7825, eISSN 1738-8872 bioconversion using LAB and discuss future directions for this field. Copyright© 2017 by The Korean Society for Microbiology Keywords: Lactic acid bacteria, fermentation, bioconversion, phenolic compound, β-glucosidase and Biotechnology Introduction be selected for their potential nutritional benefits.
    [Show full text]
  • The Biological Activities of Oleocanthal from a Molecular Perspective
    nutrients Review The Biological Activities of Oleocanthal from a Molecular Perspective Kok-Lun Pang 1 and Kok-Yong Chin 2,* 1 Biomedical Science Programme, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia; [email protected] 2 Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Malaysia * Correspondence: [email protected]; Tel.: +60-16-708-2900 Received: 10 April 2018; Accepted: 3 May 2018; Published: 6 May 2018 Abstract: Oleocanthal is a minor constituent of olive oil with strong anti-inflammatory activities. Since the pathogenesis of many chronic diseases involves inflammatory and oxidative components, oleocanthal is a promising agent to prevent these conditions. This review aimed to summarise the current beneficial health effects of oleocanthal and the molecular basis of its biological actions. The anti-inflammatory, antioxidative, antimicrobial, anticancer and neuroprotective activities of oleocanthal have been examined by previous studies. Of these, studies on the anticancer effects have been the most extensive. Oleocanthal was reported to suppress melanoma, breast, liver, and colon cancer cells. Neurological studies focused on the effects of oleocanthal against Alzheimer’s disease. Oleocanthal improved clearance of the amyloid beta protein from neurons and reduced the inflammation of astrocytes. Despite the positive results, validation of the biological effects of oleocanthal in animal disease models is limited and should be emphasized in the future. As a conclusion, oleocanthal may act together with other bioactive compounds in olive oil to achieve its therapeutic potential. The use of oleocanthal alone as a single therapeutic measure awaits validation from future studies.
    [Show full text]
  • Cholestatic Liver Injury Induced by Food Additives, Dietary Supplements
    Vrije Universiteit Brussel Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition Vilas-Boas, Vânia; Gijbels, Eva; Jonckheer, Joop; De Waele, Elisabeth; Vinken, Mathieu Published in: Environment International DOI: 10.1016/j.envint.2019.105422 10.1016/j.envint.2019.105422 Publication date: 2020 License: CC BY-NC-ND Document Version: Final published version Link to publication Citation for published version (APA): Vilas-Boas, V., Gijbels, E., Jonckheer, J., De Waele, E., & Vinken, M. (2020). Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition. Environment International, 136, [105422]. https://doi.org/10.1016/j.envint.2019.105422, https://doi.org/10.1016/j.envint.2019.105422 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
    [Show full text]
  • Redalyc.Reactivity Indexes and O-H Bond Dissociation Energies of A
    Journal of the Mexican Chemical Society ISSN: 1870-249X [email protected] Sociedad Química de México México Pérez-González, Adriana; Rebollar-Zepeda, Aida Mariana; León-Carmona, Jorge Rafael; Galano, Annia Reactivity Indexes and O-H Bond Dissociation Energies of a Large Series of Polyphenols: Implications for their Free Radical Scavenging Activity Journal of the Mexican Chemical Society, vol. 56, núm. 3, julio-septiembre, 2012, pp. 241-249 Sociedad Química de México Distrito Federal, México Available in: http://www.redalyc.org/articulo.oa?id=47524533003 How to cite Complete issue Scientific Information System More information about this article Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Journal's homepage in redalyc.org Non-profit academic project, developed under the open access initiative J. Mex. Chem. Soc. 2012, 56(3), 241-249 ArticleReactivity Indexes and O-H Bond Dissociation Energies of a Large Series of Polyphenols: Implications ©for 2012, their SociedadFree Radical Química de México241 ISSN 1870-249X Reactivity Indexes and O-H Bond Dissociation Energies of a Large Series of Polyphenols: Implications for their Free Radical Scavenging Activity Adriana Pérez-González, Aida Mariana Rebollar-Zepeda, Jorge Rafael León-Carmona, and Annia Galano∗ Departamento de Química. Universidad Autónoma Metropolitana-Iztapalapa. San Rafael Atlixco 186, Col. Vicentina. Iztapalapa. C. P. 09340. México D. F. México. [email protected] To Professor José Luis Gázquez Mateos for being a great example and a constant motivation. We sincerely thank him for sharing his kindness and knowledge with all of us. Received September 19, 2011; accepted February 20, 2012 Abstract. Several chemical descriptors have been evaluated for thirty Resumen.
    [Show full text]