DOCSLIB.ORG

Stanford University

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Stanford University Stanford University Stanford, California Reports on Federal Awards in Accordance with the Uniform Guidance August 31, 2019 EIN: 94-1156365 Stanford University Stanford, California Reports on Federal Awards in Accordance with the Uniform Guidance August 31, 2019 Page(s) I. Financial Report of Independent Auditors .................................................................................................. 1–2 Consolidated Financial Statements............................................................................................. 3–6 Notes to Consolidated Financial Statements ............................................................................. 7–77 Schedule of Expenditures of Federal Awards Part A, Award Expenditure Detail ................................................................................. 78–132 Part B, Summary of Program Clusters ........................................................................ 133–191 Part C, Federal Loan Program Year End Balances ............................................................. 192 Notes to Schedule of Expenditures of Federal Awards ............................................................... 193 II. Internal Control and Compliance Report of Independent Auditors on Internal Control Over Financial Reporting and on Compliance and Other Matters Based on an Audit of Financial Statements Performed in Accordance with Government Auditing Standards ...................................... 194-195 Report of Independent Auditors on Compliance with Requirements That Could Have a Direct and Material Effect on Each Major Program and on Internal Control Over Compliance in Accordance with the Uniform Guidance ................. 196-197 III. Findings Schedule of Findings and Questioned Costs ........................................................................ 198-200 Summary Schedule of Status of Prior Audit Findings and Questioned Costs .................... 201-206 I. Financial Report of Independent Auditors To the Board of Trustees of the Leland Stanford Junior University Report on the Consolidated Financial Statements We have audited the accompanying consolidated financial statements of the Leland Stanford Junior University and its subsidiaries (“Stanford”), which comprise the consolidated statements of financial position as of August 31, 2019 and 2018, and the related consolidated statements of activities and cash flows for the years then ended, and the related notes to the financial statements. Management’s Responsibility for the Consolidated Financial Statements Management is responsible for the preparation and fair presentation of the consolidated financial statements in accordance with accounting principles generally accepted in the United States of America; this includes the design, implementation, and maintenance of internal control relevant to the preparation and fair presentation of consolidated financial statements that are free from material misstatement, whether due to fraud or error. Auditors’ Responsibility Our responsibility is to express an opinion on the consolidated financial statements based on our audits. We conducted our audits in accordance with auditing standards generally accepted in the United States of America and the standards applicable to financial audits contained in Government Auditing Standards, issued by the Comptroller General of the United States. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the consolidated financial statements are free from material misstatement. An audit involves performing procedures to obtain audit evidence about the amounts and disclosures in the consolidated financial statements. The procedures selected depend on our judgment, including the assessment of the risks of material misstatement of the consolidated financial statements, whether due to fraud or error. In making those risk assessments, we consider internal control relevant to Stanford's preparation and fair presentation of the consolidated financial statements in order to design audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of Stanford's internal control. Accordingly, we express no such opinion. An audit also includes evaluating the appropriateness of accounting policies used and the reasonableness of significant accounting estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our audit opinion. PricewaterhouseCoopers LLP, Three Embarcadero Center, San Francisco, CA 94111-4004 T: (415) 498 5000, F: (415) 498 7100, www.pwc.com/us Opinion In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the consolidated financial position of the Leland Stanford Junior University and its subsidiaries as of August 31, 2019 and 2018, and the changes in their net assets and their cash flows for the years then ended in accordance with accounting principles generally accepted in the United States of America. Emphasis of Matter As discussed in Note 1 to the consolidated financial statements, Stanford changed the manner in which it presents net assets and reports certain aspects of its financial statements as a not-for-profit entity in 2019. Our opinion is not modified with respect to this matter. Other Matters Other Information Our audit was conducted for the purpose of forming an opinion on the consolidated financial statements as a whole. The schedule of expenditures of federal awards for the year ended August 31, 2019 is presented for purposes of additional analysis as required by Title 2 U.S. Code of Federal Regulations Part 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards (Uniform Guidance) and is not a required part of the consolidated financial statements. The information is the responsibility of management and was derived from and relates directly to the underlying accounting and other records used to prepare the consolidated financial statements. The information has been subjected to the auditing procedures applied in the audit of the consolidated financial statements and certain additional procedures, including comparing and reconciling such information directly to the underlying accounting and other records used to prepare the consolidated financial statements or to the consolidated financial statements themselves, and other additional procedures in accordance with auditing standards generally accepted in the United States of America. In our opinion, the schedule of expenditures of federal awards is fairly stated, in all material respects, in relation to the consolidated financial statements as a whole. Other Reporting Required by Government Auditing Standards In accordance with Government Auditing Standards, we have also issued our report dated December 3, 2019 on our consideration of Stanford’s internal control over financial reporting and on our tests of its compliance with certain provisions of laws, regulations, contracts and grant agreements and other matters for the year ended August 31, 2019. The purpose of that report is to describe the scope of our testing of internal control over financial reporting and compliance and the results of that testing and not to provide an opinion on internal control over financial reporting or on compliance. That report is an integral part of an audit performed in accordance with Government Auditing Standards in considering Stanford’s internal control over financial reporting and compliance. December 3, 2019 2 CONSOLIDATED STATEMENTS OF FINANCIAL POSITION At August 31, 2019 and 2018 (in thousands of dollars) 2019 2018 ASSETS Cash and cash equivalents $ 1,631,568 $ 1,199,367 Assets limited as to use 291,690 165,429 Accounts receivable, net 1,429,451 1,298,945 Prepaid expenses and other assets 448,772 329,700 Pledges receivable, net 1,469,686 1,518,486 Student loans receivable, net 51,998 60,336 Faculty and staff mortgages and other loans receivable, net 797,088 712,161 Investments at fair value, including securities pledged or on loan of $19,251 and $75,499 for 2019 and 2018, respectively 38,819,204 37,783,592 Plant facilities, net of accumulated depreciation 12,863,487 11,678,286 Works of art and special collections — — TOTAL ASSETS $ 57,802,944 $ 54,746,302 LIABILITIES AND NET ASSETS LIABILITIES: Accounts payable and accrued expenses $ 2,518,600 $ 2,291,677 Accrued pension and postretirement benefit obligations 799,313 604,592 Liabilities associated with investments 758,161 708,629 Deferred income and other obligations 1,423,315 1,212,519 Notes and bonds payable 7,074,844 6,661,644 U.S. government refundable loan funds 39,745 39,678 TOTAL LIABILITIES 12,613,978 11,518,739 NET ASSETS: Without donor restrictions 27,065,691 25,591,149 With donor restrictions 18,123,275 17,636,414 TOTAL NET ASSETS 45,188,966 43,227,563 TOTAL LIABILITIES AND NET ASSETS $ 57,802,944 $ 54,746,302 The accompanying notes are an integral part of these consolidated financial statements. 3 CONSOLIDATED STATEMENTS OF ACTIVITIES For the years ended August 31, 2019 and 2018 (in thousands of dollars) 2019 2018 NET ASSETS WITHOUT DONOR RESTRICTIONS OPERATING REVENUES: TOTAL STUDENT INCOME, NET $ 652,853 $ 635,020 Sponsored support: Direct costs - University 850,779 801,534 Direct costs - SLAC National Accelerator Laboratory 545,359
Load more

Recommended publications
  • Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity Received: 11 November 2016 Audrey E
    www.nature.com/scientificreports OPEN Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity Received: 11 November 2016 Audrey E. Hendricks1,2, Elena G. Bochukova3,4, Gaëlle Marenne1, Julia M. Keogh3, Neli Accepted: 10 April 2017 Atanassova3, Rebecca Bounds3, Eleanor Wheeler1, Vanisha Mistry3, Elana Henning3, Published: xx xx xxxx Understanding Society Scientific Group*, Antje Körner5,6, Dawn Muddyman1, Shane McCarthy1, Anke Hinney7, Johannes Hebebrand7, Robert A. Scott8, Claudia Langenberg8, Nick J. Wareham8, Praveen Surendran9, Joanna M. Howson9, Adam S. Butterworth9,10, John Danesh1,9,10, EPIC-CVD Consortium*, Børge G Nordestgaard11,12, Sune F Nielsen11,12, Shoaib Afzal11,12, SofiaPa padia3, SofieAshford 3, Sumedha Garg3, Glenn L. Millhauser13, Rafael I. Palomino13, Alexandra Kwasniewska3, Ioanna Tachmazidou1, Stephen O’Rahilly3, Eleftheria Zeggini1, UK10K Consortium*, Inês Barroso1,3 & I. Sadaf Farooqi3 Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants contributing to obesity in 2% of cases including multiple novel variants in GNAS, which were sometimes found with accelerated growth rather than short stature as described previously. Nominally significant associations were found for rare functional variants inBBS1 , BBS9, GNAS, MKKS, CLOCK and ANGPTL6. The p.S284X variant in ANGPTL6 drives the association signal (rs201622589, MAF~0.1%, odds ratio = 10.13, p-value = 0.042) and results in complete loss of secretion in cells. Further analysis including additional case-control studies and population controls (N = 260,642) did not support association of this variant with obesity (odds ratio = 2.34, p-value = 2.59 × 10−3), highlighting the challenges of testing rare variant associations and the need for very large sample sizes.
    [Show full text]
  • NOVAVERSES ISSUE 5D
    NOT ALL UNIVERSES ARE THE SAME NO: 5 NOT ALL UNIVERSES ARE THE SAME RISE OF THE CORPS Arc 1: Whatever Happened to Richard Rider? Part 1 WRITER - GORDON FERNANDEZ ILLUSTRATION - JASON HEICHEL and DAZ RED DRAGON PART 3 WRITER - BRYAN DYKE ILLUSTRATION - FERNANDO ARGÜELLO STARSCREAM PART 5 WRITER - DAZ BLACKBURN ILLUSTRATION - EMILIANO CORREA, JOE SINGLETON and DAZ DREAM OF LIVING JUSTICE PART 2 WRITER - BYRON BREWER ILLUSTRATION - JASON HEICHEL Edited by Daz Blackburn, Doug Smith & Byron Brewer Front Cover by JASON HEICHEL and DAZ BLACKBURN Next Cover by JOHN GARRETSON Novaverses logo designed by CHRIS ANDERSON NOVA AND RELATED MARVEL CHARACTERS ARE DULY RECOGNIZED AS PROPERTY AND COPYRIGHT OF MARVEL COMICS AND MARVEL CHARACTERS INC. FANS PRODUCING NOVAVERSES DULY RECOGNIZE THE ABOVE AND DENOTE THAT NOVAVERSES IS A FAN-FICTION ANTHOLOGY PRODUCED BY FANS OF NOVA AND MARVEL COSMIC VIA NOVA PRIME PAGE AND TEAM619 FACEBOOK GROUP. NOVAVERSES IS A NON-PROFIT MAKING VENTURE AND IS INTENDED PURELY FOR THE ENJOYMENT OF FANS WITH ALL RESPECT DUE TO MARVEL. NOVAVERSES IS KINDLY HOSTED BY NOVA PRIME PAGE! ORIGINAL CHARACTERS CREATED FOR NOVAVERSES ARE THE PSYCHOLOGICAL COSMIC CONSTANT OF INDIVIDUAL CREATORS AND THEIR CENTURION IMAGINATIONS. DOWNLOAD A PDF VERSION AT www.novaprimepage.com/619.asp READ ONLINE AT novaprime.deviantart.com Rise of the Nova Corps obert Rider walked somberly through the city. It was a dark, bleak, night, and there weren't many people left on the streets. His parents and friends all warned him about the dangers of 1 Rwalking in this neighborhood, especially at this hour, but Robert didn't care.
    [Show full text]
  • Elucidating Biological Roles of Novel Murine Genes in Hearing Impairment in Africa
    Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 19 September 2019 doi:10.20944/preprints201909.0222.v1 Review Elucidating Biological Roles of Novel Murine Genes in Hearing Impairment in Africa Oluwafemi Gabriel Oluwole,1* Abdoulaye Yal 1,2, Edmond Wonkam1, Noluthando Manyisa1, Jack Morrice1, Gaston K. Mazanda1 and Ambroise Wonkam1* 1Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa. 2Department of Neurology, Point G Teaching Hospital, University of Sciences, Techniques and Technology, Bamako, Mali. *Correspondence to: [email protected]; [email protected] Abstract: The prevalence of congenital hearing impairment (HI) is highest in Africa. Estimates evaluated genetic causes to account for 31% of HI cases in Africa, but the identification of associated causative genes mutations have been challenging. In this study, we reviewed the potential roles, in humans, of 38 novel genes identified in a murine study. We gathered information from various genomic annotation databases and performed functional enrichment analysis using online resources i.e. genemania and g.proflier. Results revealed that 27/38 genes are express mostly in the brain, suggesting additional cognitive roles. Indeed, HERC1- R3250X had been associated with intellectual disability in a Moroccan family. A homozygous 216-bp deletion in KLC2 was found in two siblings of Egyptian descent with spastic paraplegia. Up to 27/38 murine genes have link to at least a disease, and the commonest mode of inheritance is autosomal recessive (n=8). Network analysis indicates that 20 other genes have intermediate and biological links to the novel genes, suggesting their possible roles in HI.
    [Show full text]
  • Be and Bn Stars: Balmer Discontinuity and Stellar-Class Relationship? Y
    Astronomy & Astrophysics manuscript no. 36444corr c ESO 2020 January 1, 2020 Be and Bn stars: Balmer discontinuity and stellar-class relationship? Y. R. Cochetti1, J. Zorec2, L. S. Cidale1; 3, M. L. Arias1; 3, Y. Aidelman1, A. F. Torres1; 3, Y. Frémat2; 4, and A. Granada3; 5 1 Departamento de Espectroscopía Estelar, Facultad de Ciencias Astronómicas y Geofísicas, Universidad Nacional de La Plata, La Plata, Argentina e-mail: [email protected] 2 Sorbonne Université, CNRS, UPMC, UMR 7095, Institut d’Astrophysique de Paris, 98 bis bd. Arago, 75014 Paris, France e-mail: [email protected] 3 Instituto de Astrofísica de La Plata, CCT-La Plata, CONICET-UNLP, Paseo del Bosque s/n, CP 1900, La Plata, Buenos Aires, Argentina 4 Royal Observatory of Belgium, 3 Av. Circulaire, B-1180 Bruxelles, Belgium 5 Laboratorio de Procesamiento de Señales Aplicadas y Computación de Alto Rendimiento, Sede Andina, Universidad Nacional de Rıo Negro, Mitre 630, San Carlos de Bariloche, R8400AHN Río Negro, Argentina Received , 2019; accepted , 2019 ABSTRACT Context. A significant number of Be stars show a second Balmer discontinuity (sBD) attributed to an extended circumstellar envelope (CE). The fast rotational velocity of Be stars undoubtedly plays a significant role in the formation of the CE. However, Bn stars, which are also B-type rapidly rotating stars, do not all present clear evidence of being surrounded by circumstellar material. Aims. We aim to characterize the populations of Be and Bn stars, and discuss the appearance of the sBD as a function of the stellar parameters. We expect to find new indices characterizing the properties of CEs in Be stars and properties relating Be and Bn stars.
    [Show full text]
  • Download This Article in PDF Format
    A&A 634, A18 (2020) Astronomy https://doi.org/10.1051/0004-6361/201936444 & © ESO 2020 Astrophysics Be and Bn stars: Balmer discontinuity and stellar-class relationship? Y. R. Cochetti1, J. Zorec2, L. S. Cidale1,3, M. L. Arias1,3, Y. Aidelman1, A. F. Torres1,3, Y. Frémat2,4, and A. Granada3,5 1 Departamento de Espectroscopía Estelar, Facultad de Ciencias Astronómicas y Geofísicas, Universidad Nacional de La Plata, La Plata, Argentina e-mail: [email protected] 2 Sorbonne Université, CNRS, UPMC, UMR 7095, Institut d’Astrophysique de Paris, 98 bis bd. Arago, 75014 Paris, France e-mail: [email protected] 3 Instituto de Astrofísica de La Plata, CCT-La Plata, CONICET-UNLP, Paseo del Bosque s/n, CP 1900, La Plata, Buenos Aires, Argentina 4 Royal Observatory of Belgium, 3 Av. Circulaire, 1180 Bruxelles, Belgium 5 Laboratorio de Procesamiento de Señales Aplicadas y Computación de Alto Rendimiento, Sede Andina, Universidad Nacional de RIo Negro, Mitre 630, San Carlos de Bariloche, R8400AHN Río Negro, Argentina Received 2 August 2019 / Accepted 10 December 2019 ABSTRACT Context. A significant number of Be stars show a second Balmer discontinuity (sBD) attributed to an extended circumstellar envelope (CE). The fast rotational velocity of Be stars undoubtedly plays a significant role in the formation of the CE. However, Bn stars, which are also B-type rapidly rotating stars, do not all present clear evidence of being surrounded by circumstellar material. Aims. We aim to characterize the populations of Be and Bn stars, and discuss the appearance of the sBD as a function of the stellar parameters.
    [Show full text]
  • Marvel Universe Thor Comic Reader 1 110 Marvel Universe Thor Comic Reader 2 110 Marvel Universe Thor Digest 110 Marvel Universe Ultimate Spider-Man Vol
    AT A GLANCE Since it S inception, Marvel coMicS ha S been defined by hard-hitting action, co Mplex character S, engroSSing Story line S and — above all — heroi SM at itS fine St. get the Scoop on Marvel S’S MoSt popular characterS with thi S ea Sy-to-follow road Map to their greate St adventure S. available fall 2013! THE AVENGERS Iron Man! Thor! Captain America! Hulk! Black Widow! Hawkeye! They are Earth’s Mightiest Heroes, pledged to protect the planet from its most powerful threats! AVENGERS: ENDLESS WARTIME OGN-HC 40 AVENGERS VOL. 3: PRELUDE TO INFINITY PREMIERE HC 52 NEW AVENGERS: BREAKOUT PROSE NOVEL MASS MARKET PAPERBACK 67 NEW AVENGERS BY BRIAN MICHAEL BENDIS VOL. 5 TPB 13 SECRET AVENGERS VOL. 1: REVERIE TPB 10 UNCANNY AVENGERS VOL. 2: RAGNAROK NOW PREMIERE HC 73 YOUNG AVENGERS VOL. 1: STYLE > SUBSTANCE TPB 11 IRON MAN A tech genius, a billionaire, a debonair playboy — Tony Stark is many things. But more than any other, he is the Armored Avenger — Iron Man! With his ever-evolving armor, Iron Man is a leader among the Avengers while valiantly opposing his own formidable gallery of rogues! IRON MAN VOL. 3: THE SECRET ORIGIN OF TONY STARK BOOK 2 PREMIERE HC 90 THOR He is the son of Odin, the scion of Asgard, the brother of Loki and the God of Thunder! He is Thor, the mightiest hero of the Nine Realms and protector of mortals on Earth — from threats born across the universe or deep within the hellish pits of Surtur the Fire Demon.
    [Show full text]
  • Secondary School/ Community College Code List 2014–15
    Secondary School/ Community College Code List 2014–15 The numbers in this code list are used by both the College Board® and ACT® connect to college successTM www.collegeboard.com Alabama - United States Code School Name & Address Alabama 010000 ABBEVILLE HIGH SCHOOL, 411 GRABALL CUTOFF, ABBEVILLE AL 36310-2073 010001 ABBEVILLE CHRISTIAN ACADEMY, PO BOX 9, ABBEVILLE AL 36310-0009 010040 WOODLAND WEST CHRISTIAN SCHOOL, 3717 OLD JASPER HWY, PO BOX 190, ADAMSVILLE AL 35005 010375 MINOR HIGH SCHOOL, 2285 MINOR PKWY, ADAMSVILLE AL 35005-2532 010010 ADDISON HIGH SCHOOL, 151 SCHOOL DRIVE, PO BOX 240, ADDISON AL 35540 010017 AKRON COMMUNITY SCHOOL EAST, PO BOX 38, AKRON AL 35441-0038 010022 KINGWOOD CHRISTIAN SCHOOL, 1351 ROYALTY DR, ALABASTER AL 35007-3035 010026 EVANGEL CHRISTIAN SCHOOL, PO BOX 1670, ALABASTER AL 35007-2066 010028 EVANGEL CLASSICAL CHRISTIAN, 423 THOMPSON RD, ALABASTER AL 35007-2066 012485 THOMPSON HIGH SCHOOL, 100 WARRIOR DR, ALABASTER AL 35007-8700 010025 ALBERTVILLE HIGH SCHOOL, 402 EAST MCCORD AVE, ALBERTVILLE AL 35950 010027 ASBURY HIGH SCHOOL, 1990 ASBURY RD, ALBERTVILLE AL 35951-6040 010030 MARSHALL CHRISTIAN ACADEMY, 1631 BRASHERS CHAPEL RD, ALBERTVILLE AL 35951-3511 010035 BENJAMIN RUSSELL HIGH SCHOOL, 225 HEARD BLVD, ALEXANDER CITY AL 35011-2702 010047 LAUREL HIGH SCHOOL, LAUREL STREET, ALEXANDER CITY AL 35010 010051 VICTORY BAPTIST ACADEMY, 210 SOUTH ROAD, ALEXANDER CITY AL 35010 010055 ALEXANDRIA HIGH SCHOOL, PO BOX 180, ALEXANDRIA AL 36250-0180 010060 ALICEVILLE HIGH SCHOOL, 417 3RD STREET SE, ALICEVILLE AL 35442
    [Show full text]
  • Read Book She-Hulk by Dan Slott: the Complete Collection
    SHE-HULK BY DAN SLOTT: THE COMPLETE COLLECTION: VOLUME 1 PDF, EPUB, EBOOK Paul Pelletier,Juan Bobillo,Dan Slott | 416 pages | 25 Feb 2014 | Marvel Comics | 9780785154402 | English | New York, United States She-Hulk by Dan Slott: the Complete Collection: Volume 1 PDF Book I didn't like it enough to read the rest of his run though. There's a marriage, some mucking around with Thanos, ties in with different perspectives on Civil War and Planet Hulk and enough meta 4th wall commentary to please the average geek. Each issue features a case in court, mostly involving simplified legal cases with superheroes. Lists with This Book. For starters, t's boring. Refer to eBay Return policy for more details. Skrull Tony fought with her and then boned her because this comic is terrible. Seller assumes all responsibility for this listing. Not a title I read when I was a comic collector, however reading this collection made me wish I had. All this and the action-packed origin of Awesome Andy! Kind of wish they would have left it with him banished from the planet and no redemption arch, but it is what it is. And after the Illuminati shoot the Hulk into spac She-Hulk's strange adventures continue as she takes on her first superhuman sexual assualt case - against fellow Avenger Starfox! Want It. The man she went against in this case, Holden, eventually hires her for his own firm. Only with exploding cyborgs and interstellar tribunals and a Tony Stark I wanna punch in the mouth. However, I will concede that Slott is undoubtedly one of the better writers I know of who have gone for this approach; his sense of narrative pace seems pretty adept, and he succeeds in telling a reasonably complete and satisfying tale each issue.
    [Show full text]
  • SET Domain Containing Protein 5 (SETD5) Enhances Tumor Cell
    Yu et al. BMC Cancer (2019) 19:736 https://doi.org/10.1186/s12885-019-5944-2 RESEARCH ARTICLE Open Access SET domain containing protein 5 (SETD5) enhances tumor cell invasion and is associated with a poor prognosis in non- small cell lung cancer patients Hairu Yu1,2, Jiayi Sun1,2, Congxuan Zhao1,2, Haotian Wang3, Yeqiu Liu1,2, Jiajia Xiong1,2, Jing Chang1,2, Mixue Wang1,2, Wenhui Wang1,2, Dongman Ye1,2, Hongyan Zhou1,2 and Tao Yu1,2* Abstract Background: SET domain containing 5 (SETD5) is related to the aggressiveness of prostate and mammary cancers, but its association with non-small cell lung cancer (NSCLC) is unknown. Therefore, the purpose of this research was to determine the expression pattern and function of SETD5 in NSCLC. Methods: SETD5 was detected by immunohistochemical analysis in 147 patients with non-small cell lung cancer. SETD5 was overexpressed in A549 cells or suppressed with siRNA in H1299 cells. Wound healing and transwell assays were performed. The expression levels of SETD5, p-AKT/AKT, Snail, p-JNK/JNK, Slug, E-cadherin, Zo-1, p-P38/ P38, occludin, α-catenin, p-ERK/ERK, and p-P90RSK/ P90RSK were assessed by western blot. Results: Online analysis of overall survival in 1928 patients with NSCLC showed that the SETD5 gene was related to worse overall survival (OS)(P < 0.001). The positive expression rate of SETD5 in noncancerous tissues was lower than that in cancerous tissues (16.7% vs. 44.2%, P < 0.001). SETD5 was significantly correlated with advanced TNM stage (P < 0.001), lymph node metastasis (P < 0.001) and overall survival rate (P < 0.001).
    [Show full text]
  • A Sleeping Beauty Transposon-Mediated Screen Identifies Murine Susceptibility Genes for Adenomatous Polyposis Coli (Apc)-Dependent Intestinal Tumorigenesis
    A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis Timothy K. Starra,1, Patricia M. Scottb, Benjamin M. Marshb, Lei Zhaob, Bich L. N. Thanb, M. Gerard O’Sullivana,c, Aaron L. Sarverd, Adam J. Dupuye, David A. Largaespadaa, and Robert T. Cormierb,1 aDepartment of Genetics, Cell Biology and Development, Center for Genome Engineering, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455; bDepartment of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, MN 55812; cDepartment of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108; dDepartment of Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455; and eDepartment of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242 Edited* by William F. Dove, University of Wisconsin, Madison, WI, and approved March 2, 2011 (received for review December 1, 2010) Min Min It is proposed that a progressive series of mutations and epigenetic conducted the screen in mice carrying the Apc allele. Apc events leads to human colorectal cancer (CRC) and metastasis. mice harbor a T→A nonsense mutation in the Apc gene (4, 5) Furthermore, data from resequencing of the coding regions of that results in a truncated protein product that is unable to bind human CRC suggests that a relatively large number of mutations β-catenin and promote its degradation, thus leading to abnormal occur in individual human CRC, most at low frequency. The levels of β-catenin protein and up-regulation of β-catenin target functional role of these low-frequency mutations in CRC, and genes such as cyclin D1 (Ccnd1) and myelocytomatosis oncogene specifically how they may cooperate with high-frequency muta- (C-Myc).
    [Show full text]
  • Marvel-Phile
    by Steven E. Schend and Dale A. Donovan Lesser Lights II: Long-lost heroes This past summer has seen the reemer- 3-D MAN gence of some Marvel characters who Gestalt being havent been seen in action since the early 1980s. Of course, Im speaking of Adam POWERS: Warlock and Thanos, the major players in Alter ego: Hal Chandler owns a pair of the cosmic epic Infinity Gauntlet mini- special glasses that have identical red and series. Its great to see these old characters green images of a human figure on each back in their four-color glory, and Im sure lens. When Hal dons the glasses and focus- there are some great plans with these es on merging the two figures, he triggers characters forthcoming. a dimensional transfer that places him in a Nostalgia, the lowly terror of nigh- trancelike state. His mind and the two forgotten days, is alive still in The images from his glasses of his elder broth- MARVEL®-Phile in this, the second half of er, Chuck, merge into a gestalt being our quest to bring you characters from known as 3-D Man. the dusty pages of Marvel Comics past. As 3-D Man can remain active for only the aforementioned miniseries is showing three hours at a time, after which he must readers new and old, just because a char- split into his composite images and return acter hasnt been seen in a while certainly Hals mind to his body. While active, 3-D doesnt mean he lacks potential. This is the Mans brain is a composite of the minds of case with our two intrepid heroes for this both Hal and Chuck Chandler, with Chuck month, 3-D Man and the Blue Shield.
    [Show full text]
  • April 9Th, 2021 Dear President Biden, I Am Wr
    The White House 1600 Pennsylvania Avenue NW Washington, D.C., DC 20500 [VIA EMAIL] April 9th, 2021 Dear President Biden, I am writing to deliver a petition, attached to this letter, signed by 29,318 people urging you to put an end to the racial profiling of Asian Americans and Asian immigrants and end the Justice Department’s “China Initiative.” Asian Americans Advancing Justice | AAJC worked with directly impacted persons, who were inspired to take action but chose to remain anonymous due to fear, to launch this petition urging you to immediately end the “China Initiative” and the federal government’s racial profiling and targeting of Asian American and Asian immigrant scientists, researchers, and scholars, particularly by the Department of Justice (DOJ), the National Institutes of Health (NIH), and the National Science Foundation (NSF). We thank you for your public condemnation of racism, xenophobia, and intolerance against Asian Americans and Pacific Islanders in the United States and look forward to the administration's efforts to combat profiling within our federal institutions. Along with almost 30,000 impacted persons, concerned citizens, and community members, we seek to draw your attention to the increasing targeting and racial profiling of Asian Americans and Asian immigrants, particularly those of Chinese descent, who are working in science and technology. Asian Americans and immigrants across the country face not only the deathly impacts of the COVID-19 pandemic and devastating attacks of hate on their most vulnerable, but are also being scapegoated and targeted by law enforcement and the federal government. This fear is only heightened by racist policies and xenophobic rhetoric from public officials fueling this resurgent xenophobia.
    [Show full text]