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Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity Received: 11 November 2016 Audrey E
www.nature.com/scientificreports OPEN Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity Received: 11 November 2016 Audrey E. Hendricks1,2, Elena G. Bochukova3,4, Gaëlle Marenne1, Julia M. Keogh3, Neli Accepted: 10 April 2017 Atanassova3, Rebecca Bounds3, Eleanor Wheeler1, Vanisha Mistry3, Elana Henning3, Published: xx xx xxxx Understanding Society Scientific Group*, Antje Körner5,6, Dawn Muddyman1, Shane McCarthy1, Anke Hinney7, Johannes Hebebrand7, Robert A. Scott8, Claudia Langenberg8, Nick J. Wareham8, Praveen Surendran9, Joanna M. Howson9, Adam S. Butterworth9,10, John Danesh1,9,10, EPIC-CVD Consortium*, Børge G Nordestgaard11,12, Sune F Nielsen11,12, Shoaib Afzal11,12, SofiaPa padia3, SofieAshford 3, Sumedha Garg3, Glenn L. Millhauser13, Rafael I. Palomino13, Alexandra Kwasniewska3, Ioanna Tachmazidou1, Stephen O’Rahilly3, Eleftheria Zeggini1, UK10K Consortium*, Inês Barroso1,3 & I. Sadaf Farooqi3 Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants contributing to obesity in 2% of cases including multiple novel variants in GNAS, which were sometimes found with accelerated growth rather than short stature as described previously. Nominally significant associations were found for rare functional variants inBBS1 , BBS9, GNAS, MKKS, CLOCK and ANGPTL6. The p.S284X variant in ANGPTL6 drives the association signal (rs201622589, MAF~0.1%, odds ratio = 10.13, p-value = 0.042) and results in complete loss of secretion in cells. Further analysis including additional case-control studies and population controls (N = 260,642) did not support association of this variant with obesity (odds ratio = 2.34, p-value = 2.59 × 10−3), highlighting the challenges of testing rare variant associations and the need for very large sample sizes. -
NOVAVERSES ISSUE 5D
NOT ALL UNIVERSES ARE THE SAME NO: 5 NOT ALL UNIVERSES ARE THE SAME RISE OF THE CORPS Arc 1: Whatever Happened to Richard Rider? Part 1 WRITER - GORDON FERNANDEZ ILLUSTRATION - JASON HEICHEL and DAZ RED DRAGON PART 3 WRITER - BRYAN DYKE ILLUSTRATION - FERNANDO ARGÜELLO STARSCREAM PART 5 WRITER - DAZ BLACKBURN ILLUSTRATION - EMILIANO CORREA, JOE SINGLETON and DAZ DREAM OF LIVING JUSTICE PART 2 WRITER - BYRON BREWER ILLUSTRATION - JASON HEICHEL Edited by Daz Blackburn, Doug Smith & Byron Brewer Front Cover by JASON HEICHEL and DAZ BLACKBURN Next Cover by JOHN GARRETSON Novaverses logo designed by CHRIS ANDERSON NOVA AND RELATED MARVEL CHARACTERS ARE DULY RECOGNIZED AS PROPERTY AND COPYRIGHT OF MARVEL COMICS AND MARVEL CHARACTERS INC. FANS PRODUCING NOVAVERSES DULY RECOGNIZE THE ABOVE AND DENOTE THAT NOVAVERSES IS A FAN-FICTION ANTHOLOGY PRODUCED BY FANS OF NOVA AND MARVEL COSMIC VIA NOVA PRIME PAGE AND TEAM619 FACEBOOK GROUP. NOVAVERSES IS A NON-PROFIT MAKING VENTURE AND IS INTENDED PURELY FOR THE ENJOYMENT OF FANS WITH ALL RESPECT DUE TO MARVEL. NOVAVERSES IS KINDLY HOSTED BY NOVA PRIME PAGE! ORIGINAL CHARACTERS CREATED FOR NOVAVERSES ARE THE PSYCHOLOGICAL COSMIC CONSTANT OF INDIVIDUAL CREATORS AND THEIR CENTURION IMAGINATIONS. DOWNLOAD A PDF VERSION AT www.novaprimepage.com/619.asp READ ONLINE AT novaprime.deviantart.com Rise of the Nova Corps obert Rider walked somberly through the city. It was a dark, bleak, night, and there weren't many people left on the streets. His parents and friends all warned him about the dangers of 1 Rwalking in this neighborhood, especially at this hour, but Robert didn't care. -
Elucidating Biological Roles of Novel Murine Genes in Hearing Impairment in Africa
Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 19 September 2019 doi:10.20944/preprints201909.0222.v1 Review Elucidating Biological Roles of Novel Murine Genes in Hearing Impairment in Africa Oluwafemi Gabriel Oluwole,1* Abdoulaye Yal 1,2, Edmond Wonkam1, Noluthando Manyisa1, Jack Morrice1, Gaston K. Mazanda1 and Ambroise Wonkam1* 1Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa. 2Department of Neurology, Point G Teaching Hospital, University of Sciences, Techniques and Technology, Bamako, Mali. *Correspondence to: [email protected]; [email protected] Abstract: The prevalence of congenital hearing impairment (HI) is highest in Africa. Estimates evaluated genetic causes to account for 31% of HI cases in Africa, but the identification of associated causative genes mutations have been challenging. In this study, we reviewed the potential roles, in humans, of 38 novel genes identified in a murine study. We gathered information from various genomic annotation databases and performed functional enrichment analysis using online resources i.e. genemania and g.proflier. Results revealed that 27/38 genes are express mostly in the brain, suggesting additional cognitive roles. Indeed, HERC1- R3250X had been associated with intellectual disability in a Moroccan family. A homozygous 216-bp deletion in KLC2 was found in two siblings of Egyptian descent with spastic paraplegia. Up to 27/38 murine genes have link to at least a disease, and the commonest mode of inheritance is autosomal recessive (n=8). Network analysis indicates that 20 other genes have intermediate and biological links to the novel genes, suggesting their possible roles in HI. -
Be and Bn Stars: Balmer Discontinuity and Stellar-Class Relationship? Y
Astronomy & Astrophysics manuscript no. 36444corr c ESO 2020 January 1, 2020 Be and Bn stars: Balmer discontinuity and stellar-class relationship? Y. R. Cochetti1, J. Zorec2, L. S. Cidale1; 3, M. L. Arias1; 3, Y. Aidelman1, A. F. Torres1; 3, Y. Frémat2; 4, and A. Granada3; 5 1 Departamento de Espectroscopía Estelar, Facultad de Ciencias Astronómicas y Geofísicas, Universidad Nacional de La Plata, La Plata, Argentina e-mail: [email protected] 2 Sorbonne Université, CNRS, UPMC, UMR 7095, Institut d’Astrophysique de Paris, 98 bis bd. Arago, 75014 Paris, France e-mail: [email protected] 3 Instituto de Astrofísica de La Plata, CCT-La Plata, CONICET-UNLP, Paseo del Bosque s/n, CP 1900, La Plata, Buenos Aires, Argentina 4 Royal Observatory of Belgium, 3 Av. Circulaire, B-1180 Bruxelles, Belgium 5 Laboratorio de Procesamiento de Señales Aplicadas y Computación de Alto Rendimiento, Sede Andina, Universidad Nacional de Rıo Negro, Mitre 630, San Carlos de Bariloche, R8400AHN Río Negro, Argentina Received , 2019; accepted , 2019 ABSTRACT Context. A significant number of Be stars show a second Balmer discontinuity (sBD) attributed to an extended circumstellar envelope (CE). The fast rotational velocity of Be stars undoubtedly plays a significant role in the formation of the CE. However, Bn stars, which are also B-type rapidly rotating stars, do not all present clear evidence of being surrounded by circumstellar material. Aims. We aim to characterize the populations of Be and Bn stars, and discuss the appearance of the sBD as a function of the stellar parameters. We expect to find new indices characterizing the properties of CEs in Be stars and properties relating Be and Bn stars. -
Download This Article in PDF Format
A&A 634, A18 (2020) Astronomy https://doi.org/10.1051/0004-6361/201936444 & © ESO 2020 Astrophysics Be and Bn stars: Balmer discontinuity and stellar-class relationship? Y. R. Cochetti1, J. Zorec2, L. S. Cidale1,3, M. L. Arias1,3, Y. Aidelman1, A. F. Torres1,3, Y. Frémat2,4, and A. Granada3,5 1 Departamento de Espectroscopía Estelar, Facultad de Ciencias Astronómicas y Geofísicas, Universidad Nacional de La Plata, La Plata, Argentina e-mail: [email protected] 2 Sorbonne Université, CNRS, UPMC, UMR 7095, Institut d’Astrophysique de Paris, 98 bis bd. Arago, 75014 Paris, France e-mail: [email protected] 3 Instituto de Astrofísica de La Plata, CCT-La Plata, CONICET-UNLP, Paseo del Bosque s/n, CP 1900, La Plata, Buenos Aires, Argentina 4 Royal Observatory of Belgium, 3 Av. Circulaire, 1180 Bruxelles, Belgium 5 Laboratorio de Procesamiento de Señales Aplicadas y Computación de Alto Rendimiento, Sede Andina, Universidad Nacional de RIo Negro, Mitre 630, San Carlos de Bariloche, R8400AHN Río Negro, Argentina Received 2 August 2019 / Accepted 10 December 2019 ABSTRACT Context. A significant number of Be stars show a second Balmer discontinuity (sBD) attributed to an extended circumstellar envelope (CE). The fast rotational velocity of Be stars undoubtedly plays a significant role in the formation of the CE. However, Bn stars, which are also B-type rapidly rotating stars, do not all present clear evidence of being surrounded by circumstellar material. Aims. We aim to characterize the populations of Be and Bn stars, and discuss the appearance of the sBD as a function of the stellar parameters. -
Marvel Universe Thor Comic Reader 1 110 Marvel Universe Thor Comic Reader 2 110 Marvel Universe Thor Digest 110 Marvel Universe Ultimate Spider-Man Vol
AT A GLANCE Since it S inception, Marvel coMicS ha S been defined by hard-hitting action, co Mplex character S, engroSSing Story line S and — above all — heroi SM at itS fine St. get the Scoop on Marvel S’S MoSt popular characterS with thi S ea Sy-to-follow road Map to their greate St adventure S. available fall 2013! THE AVENGERS Iron Man! Thor! Captain America! Hulk! Black Widow! Hawkeye! They are Earth’s Mightiest Heroes, pledged to protect the planet from its most powerful threats! AVENGERS: ENDLESS WARTIME OGN-HC 40 AVENGERS VOL. 3: PRELUDE TO INFINITY PREMIERE HC 52 NEW AVENGERS: BREAKOUT PROSE NOVEL MASS MARKET PAPERBACK 67 NEW AVENGERS BY BRIAN MICHAEL BENDIS VOL. 5 TPB 13 SECRET AVENGERS VOL. 1: REVERIE TPB 10 UNCANNY AVENGERS VOL. 2: RAGNAROK NOW PREMIERE HC 73 YOUNG AVENGERS VOL. 1: STYLE > SUBSTANCE TPB 11 IRON MAN A tech genius, a billionaire, a debonair playboy — Tony Stark is many things. But more than any other, he is the Armored Avenger — Iron Man! With his ever-evolving armor, Iron Man is a leader among the Avengers while valiantly opposing his own formidable gallery of rogues! IRON MAN VOL. 3: THE SECRET ORIGIN OF TONY STARK BOOK 2 PREMIERE HC 90 THOR He is the son of Odin, the scion of Asgard, the brother of Loki and the God of Thunder! He is Thor, the mightiest hero of the Nine Realms and protector of mortals on Earth — from threats born across the universe or deep within the hellish pits of Surtur the Fire Demon. -
Secondary School/ Community College Code List 2014–15
Secondary School/ Community College Code List 2014–15 The numbers in this code list are used by both the College Board® and ACT® connect to college successTM www.collegeboard.com Alabama - United States Code School Name & Address Alabama 010000 ABBEVILLE HIGH SCHOOL, 411 GRABALL CUTOFF, ABBEVILLE AL 36310-2073 010001 ABBEVILLE CHRISTIAN ACADEMY, PO BOX 9, ABBEVILLE AL 36310-0009 010040 WOODLAND WEST CHRISTIAN SCHOOL, 3717 OLD JASPER HWY, PO BOX 190, ADAMSVILLE AL 35005 010375 MINOR HIGH SCHOOL, 2285 MINOR PKWY, ADAMSVILLE AL 35005-2532 010010 ADDISON HIGH SCHOOL, 151 SCHOOL DRIVE, PO BOX 240, ADDISON AL 35540 010017 AKRON COMMUNITY SCHOOL EAST, PO BOX 38, AKRON AL 35441-0038 010022 KINGWOOD CHRISTIAN SCHOOL, 1351 ROYALTY DR, ALABASTER AL 35007-3035 010026 EVANGEL CHRISTIAN SCHOOL, PO BOX 1670, ALABASTER AL 35007-2066 010028 EVANGEL CLASSICAL CHRISTIAN, 423 THOMPSON RD, ALABASTER AL 35007-2066 012485 THOMPSON HIGH SCHOOL, 100 WARRIOR DR, ALABASTER AL 35007-8700 010025 ALBERTVILLE HIGH SCHOOL, 402 EAST MCCORD AVE, ALBERTVILLE AL 35950 010027 ASBURY HIGH SCHOOL, 1990 ASBURY RD, ALBERTVILLE AL 35951-6040 010030 MARSHALL CHRISTIAN ACADEMY, 1631 BRASHERS CHAPEL RD, ALBERTVILLE AL 35951-3511 010035 BENJAMIN RUSSELL HIGH SCHOOL, 225 HEARD BLVD, ALEXANDER CITY AL 35011-2702 010047 LAUREL HIGH SCHOOL, LAUREL STREET, ALEXANDER CITY AL 35010 010051 VICTORY BAPTIST ACADEMY, 210 SOUTH ROAD, ALEXANDER CITY AL 35010 010055 ALEXANDRIA HIGH SCHOOL, PO BOX 180, ALEXANDRIA AL 36250-0180 010060 ALICEVILLE HIGH SCHOOL, 417 3RD STREET SE, ALICEVILLE AL 35442 -
Read Book She-Hulk by Dan Slott: the Complete Collection
SHE-HULK BY DAN SLOTT: THE COMPLETE COLLECTION: VOLUME 1 PDF, EPUB, EBOOK Paul Pelletier,Juan Bobillo,Dan Slott | 416 pages | 25 Feb 2014 | Marvel Comics | 9780785154402 | English | New York, United States She-Hulk by Dan Slott: the Complete Collection: Volume 1 PDF Book I didn't like it enough to read the rest of his run though. There's a marriage, some mucking around with Thanos, ties in with different perspectives on Civil War and Planet Hulk and enough meta 4th wall commentary to please the average geek. Each issue features a case in court, mostly involving simplified legal cases with superheroes. Lists with This Book. For starters, t's boring. Refer to eBay Return policy for more details. Skrull Tony fought with her and then boned her because this comic is terrible. Seller assumes all responsibility for this listing. Not a title I read when I was a comic collector, however reading this collection made me wish I had. All this and the action-packed origin of Awesome Andy! Kind of wish they would have left it with him banished from the planet and no redemption arch, but it is what it is. And after the Illuminati shoot the Hulk into spac She-Hulk's strange adventures continue as she takes on her first superhuman sexual assualt case - against fellow Avenger Starfox! Want It. The man she went against in this case, Holden, eventually hires her for his own firm. Only with exploding cyborgs and interstellar tribunals and a Tony Stark I wanna punch in the mouth. However, I will concede that Slott is undoubtedly one of the better writers I know of who have gone for this approach; his sense of narrative pace seems pretty adept, and he succeeds in telling a reasonably complete and satisfying tale each issue. -
SET Domain Containing Protein 5 (SETD5) Enhances Tumor Cell
Yu et al. BMC Cancer (2019) 19:736 https://doi.org/10.1186/s12885-019-5944-2 RESEARCH ARTICLE Open Access SET domain containing protein 5 (SETD5) enhances tumor cell invasion and is associated with a poor prognosis in non- small cell lung cancer patients Hairu Yu1,2, Jiayi Sun1,2, Congxuan Zhao1,2, Haotian Wang3, Yeqiu Liu1,2, Jiajia Xiong1,2, Jing Chang1,2, Mixue Wang1,2, Wenhui Wang1,2, Dongman Ye1,2, Hongyan Zhou1,2 and Tao Yu1,2* Abstract Background: SET domain containing 5 (SETD5) is related to the aggressiveness of prostate and mammary cancers, but its association with non-small cell lung cancer (NSCLC) is unknown. Therefore, the purpose of this research was to determine the expression pattern and function of SETD5 in NSCLC. Methods: SETD5 was detected by immunohistochemical analysis in 147 patients with non-small cell lung cancer. SETD5 was overexpressed in A549 cells or suppressed with siRNA in H1299 cells. Wound healing and transwell assays were performed. The expression levels of SETD5, p-AKT/AKT, Snail, p-JNK/JNK, Slug, E-cadherin, Zo-1, p-P38/ P38, occludin, α-catenin, p-ERK/ERK, and p-P90RSK/ P90RSK were assessed by western blot. Results: Online analysis of overall survival in 1928 patients with NSCLC showed that the SETD5 gene was related to worse overall survival (OS)(P < 0.001). The positive expression rate of SETD5 in noncancerous tissues was lower than that in cancerous tissues (16.7% vs. 44.2%, P < 0.001). SETD5 was significantly correlated with advanced TNM stage (P < 0.001), lymph node metastasis (P < 0.001) and overall survival rate (P < 0.001). -
A Sleeping Beauty Transposon-Mediated Screen Identifies Murine Susceptibility Genes for Adenomatous Polyposis Coli (Apc)-Dependent Intestinal Tumorigenesis
A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis Timothy K. Starra,1, Patricia M. Scottb, Benjamin M. Marshb, Lei Zhaob, Bich L. N. Thanb, M. Gerard O’Sullivana,c, Aaron L. Sarverd, Adam J. Dupuye, David A. Largaespadaa, and Robert T. Cormierb,1 aDepartment of Genetics, Cell Biology and Development, Center for Genome Engineering, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455; bDepartment of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, MN 55812; cDepartment of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108; dDepartment of Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455; and eDepartment of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242 Edited* by William F. Dove, University of Wisconsin, Madison, WI, and approved March 2, 2011 (received for review December 1, 2010) Min Min It is proposed that a progressive series of mutations and epigenetic conducted the screen in mice carrying the Apc allele. Apc events leads to human colorectal cancer (CRC) and metastasis. mice harbor a T→A nonsense mutation in the Apc gene (4, 5) Furthermore, data from resequencing of the coding regions of that results in a truncated protein product that is unable to bind human CRC suggests that a relatively large number of mutations β-catenin and promote its degradation, thus leading to abnormal occur in individual human CRC, most at low frequency. The levels of β-catenin protein and up-regulation of β-catenin target functional role of these low-frequency mutations in CRC, and genes such as cyclin D1 (Ccnd1) and myelocytomatosis oncogene specifically how they may cooperate with high-frequency muta- (C-Myc). -
Marvel-Phile
by Steven E. Schend and Dale A. Donovan Lesser Lights II: Long-lost heroes This past summer has seen the reemer- 3-D MAN gence of some Marvel characters who Gestalt being havent been seen in action since the early 1980s. Of course, Im speaking of Adam POWERS: Warlock and Thanos, the major players in Alter ego: Hal Chandler owns a pair of the cosmic epic Infinity Gauntlet mini- special glasses that have identical red and series. Its great to see these old characters green images of a human figure on each back in their four-color glory, and Im sure lens. When Hal dons the glasses and focus- there are some great plans with these es on merging the two figures, he triggers characters forthcoming. a dimensional transfer that places him in a Nostalgia, the lowly terror of nigh- trancelike state. His mind and the two forgotten days, is alive still in The images from his glasses of his elder broth- MARVEL®-Phile in this, the second half of er, Chuck, merge into a gestalt being our quest to bring you characters from known as 3-D Man. the dusty pages of Marvel Comics past. As 3-D Man can remain active for only the aforementioned miniseries is showing three hours at a time, after which he must readers new and old, just because a char- split into his composite images and return acter hasnt been seen in a while certainly Hals mind to his body. While active, 3-D doesnt mean he lacks potential. This is the Mans brain is a composite of the minds of case with our two intrepid heroes for this both Hal and Chuck Chandler, with Chuck month, 3-D Man and the Blue Shield. -
April 9Th, 2021 Dear President Biden, I Am Wr
The White House 1600 Pennsylvania Avenue NW Washington, D.C., DC 20500 [VIA EMAIL] April 9th, 2021 Dear President Biden, I am writing to deliver a petition, attached to this letter, signed by 29,318 people urging you to put an end to the racial profiling of Asian Americans and Asian immigrants and end the Justice Department’s “China Initiative.” Asian Americans Advancing Justice | AAJC worked with directly impacted persons, who were inspired to take action but chose to remain anonymous due to fear, to launch this petition urging you to immediately end the “China Initiative” and the federal government’s racial profiling and targeting of Asian American and Asian immigrant scientists, researchers, and scholars, particularly by the Department of Justice (DOJ), the National Institutes of Health (NIH), and the National Science Foundation (NSF). We thank you for your public condemnation of racism, xenophobia, and intolerance against Asian Americans and Pacific Islanders in the United States and look forward to the administration's efforts to combat profiling within our federal institutions. Along with almost 30,000 impacted persons, concerned citizens, and community members, we seek to draw your attention to the increasing targeting and racial profiling of Asian Americans and Asian immigrants, particularly those of Chinese descent, who are working in science and technology. Asian Americans and immigrants across the country face not only the deathly impacts of the COVID-19 pandemic and devastating attacks of hate on their most vulnerable, but are also being scapegoated and targeted by law enforcement and the federal government. This fear is only heightened by racist policies and xenophobic rhetoric from public officials fueling this resurgent xenophobia.