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Wo 2011/015417 A2 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 10 February 2011 (10.02.2011) WO 2011/015417 A2 (51) International Patent Classification: Road East, Bebington, Wirral Merseyside CH63 3JW A61K 8/11 (2006.01) A61Q 15/00 (2006.01) (GB). A61Q 13/00 (2006.01) (74) Agent: WHALEY, Christopher; Unilever PLC, Unilever (21) International Application Number: Patent Group, Colworth House, Sharnbrook, Bedford PCT/EP2010/059736 Bedfordshire MK44 ILQ (GB). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 7 July 2010 (07.07.2010) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, English (25) Filing Language: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (26) Publication Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (30) Priority Data: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 09167370.7 6 August 2009 (06.08.2009) EP ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (71) Applicant (for AE, AG, AU, BB, BH, BW, BZ, CA, CY, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, EG, GB, GD, GH, GM, IE, IL, KE, KN, LC, LK, LS, MT, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, MW, MY, NA, NG, NZ, OM, PG, SC, SD, SG, SL, SZ, TT, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. TZ, UG, VC, ZA, ZM, Z W only): UNILEVER PLC [GB/ (84) Designated States (unless otherwise indicated, for every GB]; Unilever House, 100 Victoria Embankment, London kind of regional protection available): ARIPO (BW, GH, Greater London EC4Y ODY (GB). GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, (71) Applicant (for all designated States except AE, AG, AU, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, BB, BH, BW, BZ, CA, CY, EG, GB, GD, GH, GM, IE, IL, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, IN, KE, KN, LC, LK, LS, MT, MW, MY, NA, NG, NZ, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, OM, PG, SC, SD, SG, SL, SZ, TT, TZ, UG, US, VC, ZA, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, ZM, ZW): UNILEVER N.V. [NL/NL]; Weena 455, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, NL-3013 AL Rotterdam (NL). GW, ML, MR, NE, SN, TD, TG). (71) Applicant (for IN only): HINDUSTAN UNILEVER Published: LIMITED [IN/IN]; Hindustan Lever House, 165/166 — without international search report and to be republished Backbay Reclamation, Maharashtra, Mumbai 400 020 upon receipt of that report (Rule 48.2(g)) (IN). (72) Inventor; and (75) Inventor/Applicant (for US only): FRANKLIN, Kevin, Ronald [GB/GB]; Unilever R&D Port Sunlight, Quarry (54) Title: FRAGRANCE-CONTAINING COMPOSITIONS (57) Abstract: An antiperspirant or deodorant composition comprising i) an antiperspirant or deodorant active, ii) a liquid carrier for the antiperspirant or deodorant active, and iii) fragrance in which the fragrance comprises a mixture of first and second fra grances, respectively (iiia) and (iiib), the first fragrance (iiia) being free from encapsulation and comprising fragrance components having a boiling point of higher than 250 0C at 1 bar pressure in a weight proportion of greater than 65% and the second fragrance (iiib) being encapsulated in a water-insoluble shear- sensitive encapsulating material and comprising fragrance components having a boiling point of greater than 250 0C at 1 bar pressure in a weight proportion of less than 65%. Fragrance-containing compositions The present invention relates to antiperspirant or deodorant compositions comprising a fragrance and in particular to such compositions containing an encapsulated fragrance as well as a fragrance that is not encapsulated, to a process for the manufacture of fragrance-containing compositions and to the non- therapeutic topical application of fragrance-containing compositions to human skin. Typical antiperspirant or deodorant compositions comprise both a deodorant active and a fragrance. Herein, the term "deodorant active" excludes a material that acts solely by masking a malodour, but includes any material that actively reduces the formation of malodour. Herein, the term "fragrance" may be used interchangeably with the word "perfume". Antiperspirant or deodorant compositions comprising both an encapsulated fragrance and a deodorant active are known. US 5,1 35,747 (Cheesebrough Ponds) discloses deodorant/antiperspirant compositions comprising both an encapsulated and non-encapsulated fragrance. US 6,1 10,449 (P&G) discloses antiperspirant compositions that include perfume/cyclodexthn complexes comprising highly volatile perfume materials having a boiling point of less than or equal to 250 C. US 5,861 ,144 (P&G) discloses antiperspirant compositions comprising both an encapsulated and non-encapsulated fragrance, both fragrances containing more than 65% by weight of volatile perfume materials having a boiling point of less than 250 C. WO 97/30689 (P&G) discloses antiperspirant compositions comprising both an encapsulated and non-encapsulated fragrance. EP 1,71 9,554 (IFF) discloses personal cleansing and/or cosmetic compositions containing enduring fragrances. According to a first aspect of the present invention, there is provided an antiperspirant or deodorant composition comprising i) an antiperspirant or deodorant active, ii) a liquid carrier for the antiperspirant or deodorant active, and iii) fragrance in which the fragrance comprises a mixture of first and second fragrances, respectively (iiia) and (iiib), the first fragrance (iiia) being free from encapsulation and being rich in fragrance components having a boiling point of higher than 25O0C at 1 bar pressure and the residue of fragrance components having a boiling point of up to 25O0C at 1 bar pressure and the second fragrance (iiib) being encapsulated in a water-insoluble shear-sensitive encapsulating material and being lean in fragrance components having a boiling point of above 25O0C at 1 bar pressure and the residue of fragrance components having a boiling point of up to 25O0C at 1 bar pressure. Such compositions according to the first aspect of the invention are intended for non-therapeutic topical application to human skin and to be left in place for an extended period of time. By so selecting the choices of fragrance components in the first (non-encapsulated) and second (encapsulated) fragrances, it is possible to achieve a comparatively level perception of fragrance over an extended period of time. In particular, by selecting a non-encapsulated (free) fragrance that is rich in components having a boiling point of above 25O0C, the release of fragrance still is a burst, but a burst over an extended period of time compared with a fragrance blend that is rich in components having a boiling point of at or below 25O0C. In addition, by selecting a blend that is lean in components having a boiling point of above 25O0C for encapsulation, it is possible for the fragrance that is released from the encapsulated fragrance to be perceived more quickly than if the encapsulated blend were rich in components having a boiling point of above 25O0C. A further benefit of compositions according to the first aspect of the invention is their excellent performance when applied to the underarms or axillae. In this environment, the water-resistance of the encapsulates and their ability to be broken by shear enables the desired fragrance profile to be delivered over an extended period of time. Further, subsequent to the composition being applied to underarms, fragrance release can be triggered by body movement, giving a fragrance boost during exercise, for example, when it most needed. In a second aspect of the invention, there is provided a process for the preparation of composition according to the first aspect in which a composition comprising the antiperspirant or deodorant active (i), the liquid carrier (ii) and the fragrances (iiia) and (iiib) are mixed together. In a third aspect, there is provided a method for inhibiting sweating or/and body odour by topical application to human skin of a composition according to the first aspect of the invention. Said method particularly involves leaving the composition on the skin for an extended period of time, such as at least 1 hour and especially at least 4 hours. In a fourth aspect, there is provided an antiperspirant or deodorant product in which a composition according to the first aspect is accommodated within a dispensing container. - A- The present invention relates to antiperspirant or deodorant compositions which contain both a free and an encapsulated fragrance, the free (non-encapsulated) fragrance being rich in perfume components having a boiling point of over 25O0C, which are sometimes called higher boiling point perfume components. The encapsulated fragrance herein is rich in lower boiling point perfume components and hence lean in higher boiling point perfume components. The term "rich" herein indicates that the proportion of the higher boiling point perfume components in the fragrance is greater than 65% by weight of the total weight of the perfume components. Herein, correspondingly, lean or poor indicates that the fragrance contains less than 65% by weight of the higher boiling point perfume components. Herein, high boiling point or high BP when used in relation to perfume components indicates a boiling point of higher than 25O0C and low boiling point or low BP, correspondingly means components having a boiling point of up to 25O0C. For many components, the boiling point can be measured at 1 bar pressure, but for some, a calculated boiling point is needed.
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  • Supplemental Material
    Haddad Supp pp 1 Supplementary materials for: Global features of neural activity in the olfactory system form a parallel code that predicts olfactory behavior and perception Rafi Haddad1,2#, Tali Weiss1, Rehan Khan1σ, Boaz Nadler2, Nathalie Mandairon3, 3 1* 1*# Moustafa Bensafi , Elad Schneidman and Noam Sobel . Section 1: PCA analysis We provide a step by step example of how we conducted the PCA analysis. Assume we have 8 odors, each located on the vertexes of a 3 dimensional unit cube. Each odor can thus be represented by the exact binary code of the numbers 0 to 7. We can represent these odors in the following binary code matrix: Odor ID Pattern code: 1 0 0 0 2 0 0 1 3 0 1 0 4 0 1 1 5 1 0 0 6 1 0 1 7 1 1 0 8 1 1 1 1 Haddad Supp pp 2 Using any available mathematical tool (we used Matlab 'princomp' method) we can calculate the principle components scores of this matrix. In this case the values of the PC1 scores are: [1 0 0]. The PC1 projection value of each row is the projection of each row by the PC1 weight vector. For example the PC1 value of the first row is [0,0,0]X[1,0,0] = 0X1 + 0X0 + 0X0 = 0. (this is a vector multiplication). Thus the PC1 value of each row of this matrix is: 0,0,0,0,1,1,1,1. Note that usually the PC1 is calculated on a centered matrix (the columns of the matrix have zero mean) and thus the PC1 value might be shifted by some value.
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