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The Inverse Agonist DG172 Triggers a Pparβ/Δ-Independent Myeloid Lineage Shift and Promotes GM-CSF/IL-4-Induced Dendritic Cell Differentiation

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The Inverse Agonist DG172 Triggers a Pparβ/Δ-Independent Myeloid Lineage Shift and Promotes GM-CSF/IL-4-Induced Dendritic Cell Differentiation Downloaded from molpharm.aspetjournals.org at ASPET Journals on September 26, 2021 1 MOL #94672 #94672 MOL -independent myeloid lineage shift and -independent myeloid lineage δ / β nagel, Wolfgang Meissner, Gavin Giehl, Cornelia Giehl, Cornelia Gavin Wolfgang Meissner, nagel, This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. 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The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 promotes GM-CSF/IL-4-induced dendritic cell differentiation Florian Finker Lieber, Frithjof Scheer, Sonja Müller Rolf and Müller-Brüsselbach Wibke Sabine Diederich, E. Brendel, and Biology for Tumor Center Tumor and (IMT), Research Molecular Biology Institute of W.M., F.F., Marburg, (S.L., R.M.); Germany (ZTI), S.M.-B., Philipps Immunology University, (ZTI), Tumor and Immunology Biology for Center Pharmaceutical Chemistry, Institute of Oncology Hematology, W.E.D.); for and Clinic (F.S., Germany Marburg, University, Philipps University, (ZTI), and Philipps Immunology for Center Biology Tumor and Immunology, Marburg, Germany C.B.). (G.G., The inversetriggers agonist DG172 a PPAR Molecular Pharmacology Fast Forward. Published on November 14, 2014 as DOI: 10.1124/mol.114.094672 This article has not been copyedited and formatted. The final version may differ from this version. MOL #94672 RUNNING TITLE: DG172 promotes the differentiation of dendritic cells CORRESPONDING AUTHOR: Dr. Rolf Müller, Institute of Molecular Biology and Tumor Research (IMT), Center for Tumor and Immunobiology (ZTI), Philipps University, Hans- Meerwein-Straße 3, 35043 Marburg, Germany. Email: [email protected] No. of text pages: 23 (incl. title pages and legends) No. of tables: 0 No. of figures: 10 Downloaded from No. of references: 53 No. of words in the Abstract: 227 No. of words in the Introduction: 610 No. of words in the Discussion: 1254 molpharm.aspetjournals.org ABBREVIATIONS: Angptl4, angiopoietin-like 4; BMC, bone marrow cell; DC, dendritic cell; DG172,
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