Queensland Brain Institute 2014 Annual Report

Queensland Brain Institute 2014 Annual Report Queensland Brain Institute 2014 Annual Report Cover Image: Garden of Neurons by Gonzalo Almarza We are studying diﬀerent populations of neurons in the cortex. In this image, subplate neurons (green) extend their processes towards the pial surface during early cortical development. These neurons project through the emerging cortical plate (in red), arborising in the marginal zone (in blue). Queensland Brain Institute Annual Report 2014

UQ Vice-Chancellor and President’s Report ...... 1 QBI Director’s Report ...... 2

Discovery 4 Genome analysis reveals schizophrenia’s secrets ...... 6 Halting the damaging eﬀects of stroke ...... 8 Revealing the complexity of wiring the brain...... 10 Redeﬁning how we plan movement in the brain ...... 12 Controlling fear may be possible by controlling DNA ...... 14

Research 16 Anggono Laboratory ...... 17 Goodhill Laboratory ...... 27 Mowry Laboratory ...... 37 Srinivasan Laboratory ...... 43 Bartlett Laboratory ...... 18 Götz Laboratory ...... 28 Osborne Laboratory ...... 38 van Swinderen Laboratory ...44 Bredy Laboratory ...... 19 Hilliard Laboratory ...... 29 Piper Laboratory ...... 39 Visscher Laboratory ...... 45 Burne Laboratory ...... 20 Jiang Laboratory ...... 30 Reinhard Laboratory ...... 40 Williams Laboratory ...... 46 Cheung Laboratory ...... 21 Lynch Laboratory ...... 31 Richards Laboratory ...... 41 Wray Laboratory ...... 47 Claudianos Laboratory...... 22 Mangelsdorf Laboratory .....32 Sah Laboratory ...... 42 Yang Laboratory ...... 48 Cooper Laboratory ...... 23 Marshall Laboratory ...... 33 Clem Jones Centre for Ageing Dementia Research ...... 49 Coulson Laboratory ...... 24 Mattingley Laboratory ...... 34 Centre for Neurogenetics and Statistical Genomics ...... 50 Cunnington Laboratory ...... 25 McGrath Laboratory ...... 35 Science of Learning Research Centre ...... 51 Eyles Laboratory ...... 26 Meunier Laboratory ...... 36 Joint Research Laboratories ...... 52

Students 54 Postgraduate Students ...... 55 Master of Neuroscience ...... 58 Student Proﬁles ...... 56

Community 60 Lectures ...... 61 Community Outreach ...... 65 Events ...... 63 Australian Brain Bee Challenge ...... 66

Recognition 68 Fellowships and Awards ...... 69 Editorial Boards...... 89 Commercial Development ...... 70 UQ Appointments ...... 90 Publications ...... 71 International Collaborations ...... 91 Grants ...... 83 Staﬀ ...... 93 Neuroscience Seminars ...... 85 Philanthropy ...... 97 Professional Services ...... 87 Acknowledgements ...... 99 UQ Vice-Chancellor and President’s Report

I am delighted to share with you a selection of the QBI also hosted 24 Chinese students from Fudan many successes achieved at the Queensland Brain University and Wenzhou Medical College as part Institute (QBI) in 2014. of a six-week engagement at UQ to tighten ties between the institutions. Their positive experiences Under the strong leadership of founding Direc- will produce benefits well into the future for people tor, Professor Perry Bartlett, QBI has progressively of both countries and for the global community. augmented an exemplary record built on collaborations, beginning with robust research partnerships Meanwhile, QBI continued to invest in coming at UQ, and extending to global research consorti- generations of Australian knowledge leaders, and ums, philanthropists and companies. welcomed teenagers from more than 60 high schools for the 2014 Queensland Final of the Austral- The continued growth of the Clem Jones Centre for ian Brain Bee Challenge. Queensland has produced Ageing and Dementia Research (CJCADR), led by two of the last three champions of the International Professor Jürgen Götz, is testament to the power Brain Bee—and the Australian component owes its of collaboration. In 2014, CJCADR joined with the existence to QBI’s Professor Linda Richards, who Chinese Academy of Sciences’ Institute of Biophys- founded the competition here in 2006. ics to create an Australia-China centre focussed on dementia research. Before finishing, I wish to congratulate Professor Perry Bartlett for being awarded the prestigious Further enhancing this work, the Stafford Fox Med- Distinguished Achievement Award by the Aus- ical Research Foundation gifted $2.5 million for an tralian Neuroscience Society. Perry is a lion of international fellowship to study stroke-induced neuroscience, who during a 40-year career has dementia—the cause of around 40 per cent of been responsible for a series of ground-breaking dementias. Also thanks to philanthropic support, discoveries that will have perpetual positive impact. German postdoctoral researcher and recipient of His global reputation and unflagging commitment the prestigious Peter Hilton Research Fellowship to excellence and outcomes have helped attract in Ageing Dementia Dr Liviu-Gabriel Bodea joined outstanding staff, students and partners to the CJCADR. Dr Bodea’s expertise in neuroimmunology QBI. You will see overviews of some of their work adds significant traction to QBI’s dementia program. in the pages that follow. I congratulate and thank QBI has continued its strong commitment to young each and every one. The best news, perhaps, is scientists, and in 2014 two early career research- that the best is yet to come! ers, Dr Ramesh Narayanan and Dr Roger Marek, Professor Peter Høj received The University of Queensland’s Dean’s Vice-Chancellor and President Award for Research Higher Degree Excellence, for The University of Queensland theses submitted in 2013. Dr Narayanan’s winning work advanced knowledge of the mechanisms behind motor neuron disease; Dr Marek’s thesis focussed on the neuronal circuit that is involved in the acquisition and extinction of fear memory. Both researchers reflect the extreme dedication to research outcomes exhibited across QBI’s faculty.

1 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

QBI Director’s Report

In the world’s largest molecular genetic study into honour, the Harold Spencer-Jones Gold Medal, to and success of QBI. In particular, I wish to acknowl- a psychiatric disorder, using DNA samples from Professor Mandyam Srinivasan. Professor Srin- edge the support delivered by Professor Pankaj 36,989 schizophrenia patients, researchers used ivasan studies insects and birds to understand Sah and his team of Ms Rowan Tweedale and Dr a genome-wide association study to find genetic how animals with small brains navigate complex Sylvie Pichelin, along with the administrative sup- variations between the patients and 113,075 con- environments. He applies that research in the field port provided by Deputy Director (Operations), Mr trol samples. The study uncovered 108 sites, 83 of of robotics to help unmanned aerial vehicles avoid John Kelly, and Institute Manager, Mrs Helen Weir. which were previously unidentified, that form the collisions and safely navigate their environments. I also wish to recognise the role of the QBI Advisory genetic underpinnings of schizophrenia, which is In 2014, Professor Srinivasan was also named an Board, chaired by Dr Sallyanne Atkinson AO ,in an incredible result. inaugural Queensland Government Science Cham- guiding the Institute, and the QBI Development pion and elected into the Australian Academy of Following this, I was delighted to announce the Board, chaired by Mr Jeff Maclean. Your support and Science Council. appointment of Professor Peter Visscher and Profes- generosity has enabled QBI to maintain its leading sor Naomi Wray as Co-Directors of the new Centre QBI laboratory head Professor Peter Visscher position as a hub for neuroscience discovery and for Neurogenetics and Statistical Genomics (CNSG), was identified on the prestigious 2014 Thomson translation, and I look forward to your continued here at QBI. The Centre aims to understand the Reuters Highly Cited Researchers list. The list iden- support and friendship in 2015. genetic basis of a range of brain diseases and to tifies researchers ranked in the top one per cent I extend my personal gratitude to our many donors develop new statistical methodologies and compu- by citation rate during 2002–2012, with Professor and supporters, as this support is paramount to tational tools to aid analysis of the human genome. Visscher appearing in the category of Molecular the success of the Institute. Biology & Genetics. In this year’s Annual Report you will also find fea- Finally, my warmest thanks to Vice-Chancellor and tured the work of QBI Deputy Director (Research) Professor Justin Marshall was awarded the ARC’s President Professor Peter Høj, and Provost and Professor Pankaj Sah on how the brain plans move- most prestigious fellowship, the Laureate Fellow- Senior Vice-President Max Lu for their guidance ment. In collaboration with neurologist Professor ship, one of only 16 awarded across Australia. This and support. At a time when research funding is becoming Peter Silburn and neurosurgeon Associate Profes- was in recognition of his pioneering work in discov- increasingly more competitive, I am delighted with sor Terry Coyne from the UQ Centre for Clinical ering the neuroscientific basis of vision in marine Thank you again for your support, the success of our scientists in obtaining fellowships Research, Professor Sah examined the brains of 10 animals, which is deepening on our understand- and grants totalling more than $26.5 million in patients with Parkinson’s disease while the patients ing of human vision and being used to develop 2014. In addition, we have received commitment were awake during deep brain stimulation surgery. innovative devices to record visual information. for three new research multi-year fellowships to They found more than one part of the brain is I was deeply honoured to receive the Australasian commence at QBI in 2015, supported entirely by responsible for planning movement. This improved Neuroscience Society (ANS) Distinguished Achieve- the philanthropy of our wonderful supporters. understanding of how the brain plans movement ment Award, granted “in honour of an outstanding could lead to more targeted treatments for people In our eleventh year, I reflect with satisfaction on the contribution by an individual to neuroscience in with Parkinson’s. Professor Perry Bartlett FAA growth of QBI’s publications in high impact scien- Australia”. This was especially pleasing because Director, Queensland Brain Institute tific journals, from the very first paper published in Professor Sah should also be commended for his it recognises the achievements of the many stu- Nature Neuroscience in 2002, to this year’s output appointment as Director of the Science of Learning dents and postdoctoral fellows who I have been of seven in Nature, one in Science, two in Neuron Research Centre (SLRC), a Special Research Initiative fortunate to have worked with over the past 40 and 15 in other named Nature journals among the of the Australian Research Council. Professor Sah years. In addition, I was greatly honoured to join 277 papers published in frontline journals. is internationally renowned for his work in under- the small group of distinguished scientists who standing the role of the amygdala—the area of the have previously received this award: David Curtis We have featured a selection of these discoveries brain involved in emotional processing—in learning. (2009), Elspeth McLachlan (2006), John Furness in this year’s Annual Report, including Professors (2003), Max Bennett (2001), Stephen Redman (2000) Bryan Mowry, Naomi Wray and Peter Visscher’s In addition to this recognition of high achievement, and Lawrie Austin (1993). work in revealing dozens of sites across the human our scientists received many awards during 2014. genome that are strongly associated with genetic I wish to thank my many colleagues and friends HRH Prince Philip, The Duke of Edinburgh pre- predisposition to schizophrenia. who directly contributed to the Award and who sented the Royal Institute of Navigation’s highest have continued to be indispensable to the growth

REPORTS 2

Queensland Brain Institute Annual Report 2014

Discovery

The Queensland Brain Institute has rapidly positioned itself as one of the world’s leading neuroscience research facilities.

QBI fosters an environment of discovery that will ultimately lead to the development of much-needed therapeutic treatments to combat diseases in which brain function has failed or is compromised.

Here, we celebrate some of QBI’s fundamental breakthroughs in 2014.

Nadia Cummins, Götz Laboratory.

DISCOVERY 4 “These are very exciting ﬁndings that will no doubt bring hope to the quarter of a million Australians who have schizophrenia and to their families and carers.” Queensland Brain Institute Annual Report 2014

Genome analysis reveals schizophrenia’s secrets

“This provides the potential for understanding “Interestingly, by far the strongest genetic finding the causes of the illness and for discovering new links schizophrenia to a region previously identified treatments,” he said. in autoimmune diseases, implying the possibility of an autoimmune pathology in the disease, and These locations were not randomly distributed is one that warrants further investigation.” across the genome but converged upon genes that were expressed in certain tissues, particularly Using DNA samples from 36,989 schizophrenia the brain and in tissues with important immune patients, researchers used a genome-wide asso- functions. ciation study to find genetic variations between the patients and 113,075 control samples. “These are very exciting findings that will no doubt bring hope to the quarter of a million Australians “By screening the DNA of people with schizophrenia who have schizophrenia and to their families and and those without it at millions of DNA markers carers,” Professor Mowry said. across the human genome, we were able to determine which markers were statistically significantly “This study constitutes a rapid advance in our associated with this disorder,” Professor Mowry said. understanding of the genetic architecture of Effective treatments for schizophrenia are closer after schizophrenia, opening the door to expanding “The next steps will involve determining the func- dozens of new sites across the human genome strongly our understanding of its underlying biology.” tional basis of these genetic signals and how they interact together to cause illness, and then develop Schizophrenia is a highly inheritable, debilitating associated with genetic predisposition to schizophrenia new therapeutic interventions.” psychiatric disorder that affects about one in every were uncovered. 100 people worldwide, and is characterised by hal- UQ partnered with more than 200 organisations in The study, published in Nature, involved Professor lucinations, disturbed beliefs and a breakdown of the Schizophrenia Working Group of the Psychiatric Bryan Mowry, who said it was the world’s largest thought processes. Genomics Consortium, including researchers from molecular genetic study into a psychiatric disorder. QBI, QCMHR and the Royal Brisbane and Women’s It is ranked ninth in the global burden of illness Hospital Department of Psychiatry. Professor Mowry said the study found 108 sites, 83 and is estimated to cost Australian society $5 bil- of which were previously unidentified, that formed lion a year. QBI’s Professor Naomi Wray, Professor Peter Viss- the genetic underpinnings of schizophrenia. cher, and Dr Sang Hong Lee also contributed to Despite the huge cost to individuals and to society, the analyses of the dataset. only in the past five years has substantial progress been made.

Above left: A ‘Manhattan plot’ showing the sites across the human genome that are associated with a genetic predisposition to schizophrenia. Far left: Professor Bryan Mowry.

DISCOVERY 6 “We’ve found that a molecule called CAL-101 could selectively prevent excess neuroinﬂammation.” Queensland Brain Institute Annual Report 2014

Halting the damaging eﬀects of stroke

CAL-101 CAL-101 WT p110D910A DMSO pre post

result in extra trauma as blood rushes back into The estimated economic burden in Australia is highly delicate areas already damaged in the brain. $49.3 billion. “Whenever you have a clot, you have inflammation, CAL-101 was named molecule of the year by the and when this happens in the brain it is very bad FDA in America for the treatment of Hodgkin news,” Professor Meunier said. lymphoma, leaving the researchers hopeful that use of the molecule as a stroke treatment could “Therefore it’s critical to stop inflammation follow- be fast-tracked. ing clotting in the brain, and we’ve found that a molecule called CAL-101 would selectively prevent Though stroke is known to be a major cause of excess neuroinflammation.” disability, with one Australian suffering a stroke every 10 minutes, fewer people understand the The team found that mice treated with CAL-101, a longer-term consequences. selective phosphoinositide-3 kinase delta (PI3Kδ) inhibitor, received up to three hours of protection Additionally, stroke is the cause for around 40 per against the excessive secretion of tumour necrosis cent of dementias, highlighting the impact that the factor (TNF) that causes inflammation. condition can have ‘down-stream’ for longer-term Professor Fred Meunier led an international team to dis- consequences beyond the initial event. Results showed that there is a window of oppor- cover a new avenue for the treatment of the debilitating tunity for treatment before further damage is QBI worked together with UQ’s School of Biomed- effects of ischaemic stroke on patients. caused, and this method would be an ideal first ical Sciences and Institute for Molecular Bioscience, response treatment administered in conjunction as well with researchers from the University Medical with current treatments. Center Hamburg-Eppendorf, Germany; University The team discovered that the molecule CAL-101 College London, UK; and Monash University. can be used to stop inflammation of the brain. The findings of this highly promising therapeutic strategy coincide with current public health mes- The study was published in Nature Communications. Professor Meunier said that current stroke treat- sages to identify the signs of stroke, and seek ments—primarily aspirin or tissue plasminogen immediate medical treatment for a stroke victim. activator—clear clots caused by stroke, but often

Above left: Decrease in infarct volume in p110δD910A mice (left) and mice treated with the p110δ inhibitor CAL-101 (right) and subjected to experimental ischaemic stroke. Far left: Professor Frederic Meunier.

DISCOVERY 8 “These results help us to understand how brain wiring occurs, which is fundamental for brain function.” Queensland Brain Institute Annual Report 2014

Revealing the complexity of wiring the brain

Work in the Richards Laboratory showed that the “These results expand our understanding of how developing corpus callosum requires balanced sen- functional brain circuits form during development,” sory input from both sides of the body in order Dr Suárez said. to form the right connections between the two “For example, not only sensory-evoked but also brain hemispheres. spontaneous activity is employed by these axons “These results help us to understand how brain to accurately find their contralateral targets.” wiring occurs, and correct brain wiring is funda- The research paper also showed that malformations mental for brain function,” Professor Richards said. of the corpus callosum can occur in subtle ways, Malformations of the corpus callosum have an as connections were disrupted only in their final incidence of at least one in 3,000 people and result stages of being established. in a wide range of symptoms such as poor coordi- Small alterations of circuit connectivity during nation, delayed childhood development milestones postnatal stages may have an impact on the such as walking, and even lower perception of pain. development of psychiatric illnesses. Corpus callosum malformations are also some- “The work advances our knowledge about how A study discovered that early experience affects how times associated with psychiatric illnesses such as corpus callosum axons find their correct targets schizophrenia and autism. the two sides of the brain are wired together after birth. in the opposite hemisphere, which could have The study was conducted in developing mice and wide-reaching implications for numerous brain The study led by Professor Linda Richards found found that when corpus callosum neurons were disorders involving altered brain connectivity,” Ms that balanced sensory input from both sides of deprived of sensory or endogenous activity in one Fenlon said. the body is required for correct wiring to occur. brain hemisphere they wired incorrectly. The researchers now want to learn how the bal- The connections that were highlighted in this study This process could be rescued by manipulating anced activity influences the corpus callosum comprise a large fibre tract called the corpus callo- activity in both hemispheres in a symmetric neurons to change their growth, and they are sum, which acts as a bridge between the two halves manner, demonstrating that not just overall acti- also looking for genes that might be involved in of the brain and plays a role in the development vation, but balanced levels of neuronal activity this process. of social skills, language, touch, vision, hearing, between brain hemispheres are critical for pre- The study was published in the prestigious journal and motor control. cise wiring. Neuron. These connections form during brain development Dr Rodrigo Suárez and PhD candidate Ms Laura and are shaped by both genes and experience. Fenlon were co-lead authors on the study.

Above left: A green ﬂuorescent protein was used to label neurons that project their axons across the mouse brain, from the left to the right side, via the corpus callosum. Far left (L-R): PhD candidate Laura Fenlon, Professor Linda Richards and Dr Rodrigo Suárez.

DISCOVERY 10 “Improved understanding of how the brain plans movement could lead to more targeted treatments for people with Parkinson’s.” Queensland Brain Institute Annual Report 2014

Redeﬁning how we plan movement in the brain

Professor Pankaj Sah from QBI collaborated with “This is a complete surprise, because the general neurologist Professor Peter Silburn and neurosur- thinking has been that movement planning takes geon Associate Professor Terry Coyne from the UQ place in the cortex, but this study indicates it might Centre for Clinical Research. be happening in the brain stem as well,” Professor Sah said. “This study aimed to improve understanding of how different parts of the brain are involved in planning Parkinson’s disease is the second most common movement and controlling gait,” Professor Sah said. neurodegenerative disorder after Alzheimer’s disease, affecting more than six million people globally, The team was particularly interested in a part of and about one in 350 Australians. the brain stem known as the pedunculopontine nucleus (PPN), which lies in the brainstem, one of Professor Sah said improved understanding of the deepest parts of the brain. how the brain plans movement could lead to more targeted treatments for people with Parkinson’s. The PPN has previously been targeted as a treatment point for people with advanced Parkinson’s “The cells involved in these networks seem to be disease who have difficulty in initiating movement one type of cell, so when thinking about drug A surprise discovery about how the brain plans movement or have ‘freezing of gait’. treatments for Parkinson’s, maybe we should be targeting these cells,” he said. that may lead to more targeted treatments for patients “To date, we have known that walking is generally with Parkinson’s disease. controlled by the outer part of the brain known All the patients treated with deep brain stimulation A part of the brain that was thought to be only as the cortex,” Professor Sah said. during the study also recorded positive outcomes involved in controlling movement also plays a key with improvements in gait, highlighting the impor- “When you decide to walk, the cortex sends signals role in planning movement. tance of neuroscientists working with clinicians. to your brain stem which in turn signals the spinal The finding was made while recording the brain cord to initiate movement.” Findings of the research are published in the journal activity in patients with Parkinson’s disease, during Nature Neuroscience. It had been known that neurons in the PPN are acti- surgery to implant electrodes for deep brain stim- vated during limb movement; however, the study ulation to treat problems with gait. showed they were also activated when patients were simply thinking about walking.

Above left: The trajectory of a deep brain stimulation electrode (blue) aimed at its target the pedunculopontine nucleus (red), are overlaid on a magnetic resonance image. Far left: Professor Pankaj Sah.

DISCOVERY 12 “Rather than being static, the way genes function is incredibly dynamic and can be altered by our daily life experiences, with emotionally relevant events having a pronounced impact.” Queensland Brain Institute Annual Report 2014

Controlling fear may be possible by controlling DNA

Context only

Fear-conditioned

Senior research fellow Dr Timothy Bredy and his of rapid behavioural adaptation, and that impair- team have found a novel mechanism of gene ments in this process were critically involved in Fear-conditioned regulation associated with fear extinction, an the development of fear-related anxiety disorders. without extinction inhibitory learning process thought to be critical “What is most exciting is that we have revealed an for controlling fear when the response was no epigenetic state that appears to be quite specific longer required. for fear extinction,” Mr Li said. Extinction “Rather than being static, the way genes function Dr Bredy said this was the first comprehensive is incredibly dynamic and can be altered by our analysis of how fear extinction was influenced by daily life experiences, with emotionally relevant modifying DNA. events having a pronounced impact,” Dr Bredy said. “It highlights the adaptive significance of expe- By understanding the fundamental relationship 02468 rience-dependent changes in the chromatin Relative enrichment level between the way in which DNA functions without a landscape in the adult brain,” he said. change in the underlying sequence, future targets for therapeutic intervention in fear-related anxiety Collaborative research into the field is continuing Loosening the grip of fear-related memories, particu- disorders could be developed. by a team from QBI, the University of California, Irvine, and Harvard University. larly those implicated in conditions such as phobia and “This may be achieved through the selective enhancement of memory for fear extinction by The study was published in Proceedings of the post-traumatic stress disorder, may now be possible due targeting genes that are subject to this novel mode National Academy of Sciences of the USA. to a new discovery. of epigenetic regulation,” he said. QBI neuroscientists shed new light on the processes Mr Xiang Li, a PhD candidate and the study’s lead behind the mechanism, and may have found a way author, said fear extinction was a clear example to silence the gene that feeds fear.

Above left: Diﬀerences in experience-dependent 5-hydroxymethylcytosine enrichment in fear-conditioned mice, and those that had been trained to remove the fear-conditioning. Far left: Dr Wei Wei from the Bredy Laboratory.

DISCOVERY 14

Queensland Brain Institute Annual Report 2014

Research

QBI is a world-leading research facility whose staﬀ are committed to discovering the fundamental mechanisms regulating brain function.

QBI’s research provides the opportunity to address the overwhelming tide of neurological disease and mental ill health in the community.

Dr Jens Bunt, Richards Laboratory.

RESEARCH 16 Laboratory Head Dr Victor Anggono

2014 Laboratory Members L–R/T–B: Victor Anggono, Ye Jin Chai, Yu Qian Chau, Se Eun (Joanne) Jang, Daniel Lim, Tong (Tina) Lin. Not pictured: Dirga Rachmad Aprianto, Kithmini Weerasinghe. Image: Dynamic regulation of AMPA receptor traﬃcking into and out of the postsynaptic membrane by various intracellular interacting proteins.

Molecular mechanisms of AMPA receptor trafficking The AMPA-type neurotransmitter receptors mediate In collaboration with Professor Richard Huganir at In addition, the Anggono group uncovered the roles most of the fast synaptic transmissions in the brain. The Johns Hopkins University School of Medicine, of post-translational ubiquitination in regulating The ability of neurons to modulate the strength USA, the Anggono group identified an interaction activity-dependent AMPA receptor intracellular of their connections, termed synaptic plasticity, is between the AMPA receptor subunit and sorting trafficking, sorting and degradation. Part of this determined in part by the number of these recep- nexin 27 (SNX27), a protein previously implicated work was presented at the 44th Society for Neuro- tors at synapses. Dysregulation in AMPA receptor in Down syndrome. The loss of SNX27 function science annual meeting in Washington, D.C., USA trafficking results in the imbalance in neuronal impairs AMPA receptor trafficking towards the and the 7th Garvan Institute Signalling Sympo- excitation and inhibition, which often results in plasma membrane, resulting in impairment of sium in Sydney. The laboratory also received the memory impairment and cognitive deficit associ- long-term potentiation, a form of cellular memory. Alzheimer’s Australia Dementia Research Founda- ated with various neurological disorders, such as This study was published in the Proceedings of the tion Project Grant to continue this research in 2015. Alzheimer’s disease, schizophrenia, bipolar disor- National Academy of Sciences of the United States ders and autism. The major aim of the Anggono of America (2014). Together with Dr Brett Collins group is to understand the detailed molecular at the Institute for Molecular Bioscience, UQ, the mechanisms regulating AMPA receptor trafficking, group is currently extending the study to provide synaptic plasticity, learning and memory. in-depth structure-function analysis of SNX27 in The distribution of internalised AMPA receptors (red) regulating AMPA receptor functions. and early endosomes (yellow) in a hippocampal neuron.

17 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Dr Victor Anggono Laboratory Head Professor Perry Bartlett

2014 Laboratory Members L–R/T–B: Perry Bartlett, Daniel Blackmore, Lavinia Codd, Dhanisha Jhaveri, Imogen O’Keeﬀe, Gregory Robinson, Chanel Taylor, Jana Vukovic, Jing Zhao. Not pictured: James Cleland, Odette Leiter, Weichuan Mo (based in China), Xiaoqing (Alice) Zhou. Image: Two diﬀerentiated neurospheres grow beside each other, however upon contact one will begin to unravel as astrocytes (turquoise) pour out of the disintegrating sphere, and the neurons (red) struggle to stay in place. Image by Chanel Taylor.

Understanding the mechanisms driving hippocampal neurogenesis Professor Perry Bartlett’s laboratory is dedicated its effects by binding to adrenergic receptors. The This finding adds to our understanding of the role to understanding the mechanisms that drive the Bartlett laboratory, with collaborators from the Tata of microglia in regulating neurogenesis, as previ- continuous production of new neurons from the Institute of Fundamental Research in India, demon- ous work has shown that KATP channel blockade resident pool of neural stem cells in a region of strated the importance of the balance between promotes neurogenesis after stroke. the adult brain known as the hippocampus. This α - and β-adrenergic receptor activity (Jhaveri et 2 The Bartlett laboratory also conducts research process, called neurogenesis, slows as we age, and al., PLOS One, 2014). The study shows that, when into the treatment of spinal cord injury. They this loss of neurons has been associated with a loss stimulated, α -adrenergic receptors inhibit whereas 2 have shown that blocking the activity of the EphA4 of cognitive function. The group is now focussed β-adrenergic receptors enhance precursor cell acti- receptor results in significantly improved recovery on identifying the factors that can trigger activa- vation and neurogenesis in the hippocampus. This of motor function after spinal cord injury. In 2014, tion of stem cells to enhance production of these study provides a potential mechanism by which Professor Bartlett, with Associate Professor Martin newborn neurons. norepinephrine-promoting drugs could enhance Lackmann and Professor Andrew Boyd, published a adult neurogenesis. The group also published work Hippocampal-dependent functions, such as learn- review (in the journal Nature Reviews Drug Discov- Hippocampal precursor cells residing in the adult showing that blockade of microglial K channels ing, memory and mood, are regulated by the ATP ery) on the rapidly evolving area that is therapeutic dentate gyrus exhibit radial-glial like processes and abrogates the suppression of precursor cell activity neurotransmitter norepinephrine, which exerts targeting of Eph receptors and their ligands. co-express glial fibrillary acidic protein (red) and GFP by inflammatory cytokines (Ortega et al., Glia, 2014). (green) in a transgenic (Hes5-GFP) mouse. Image by Dhanisha Jhaveri.

RESEARCH 18 Laboratory Head Dr Timothy Bredy

2014 Laboratory Members L–R/T–B: Timothy Bredy, Danay Baker-Andresen, Laura Leighton, Xiang Li, Vikram Ratnu, Paola Spadaro, Wei Wei, Jocelyn Widagdo. Image: Activated neurons in the cortex of a mouse following behavioural training.

Epigenetic mechanisms regulating memory The extinction of conditioned fear—the reduction Research in the Bredy laboratory is elucidating of the USA; Genes, Brain and Behavior; and the in respondse to a feared cue when the cue is how the genome is connected to the environment European Journal of Neuroscience. In other work, repeatedly presented without any adverse con- through epigenetic modifications, and how this which appeared in the journal Molecular Psychiatry, sequence—is an important model for the treatment relationship shapes behaviour across the lifespan. together with collaborators the group demon- of anxiety disorders. Like other forms of learning, The group is particularly interested in how epi- strated that the long non-coding RNA Gomafu is long-lasting memory for fear extinction depends genetic mechanisms, including DNA methylation, both activity-dependent and associated with schiz- on coordinated gene expression and the synthesis histone modifications and the activity of non-cod- ophrenia. The work received significant exposure of new synaptic proteins. This process involves a ing RNAs, regulate the formation and maintenance in 2014 with invited talks at several international tightly controlled interplay between transcriptional of memory. meetings, including those for the Molecular and machinery and enzymes that regulate chroma- Cellular Cognition Society, the Federation of Euro- 2014 was a productive year for the laboratory, tin structure, a relatively recent field of research pean Neuroscience Society in Italy, the Canadian which published new studies on the role of DNA referred to as epigenetics. Association for Neuroscience in Montreal, and the methylation and neural plasticity in the journals 5th ERTC Conference in Shanghai, China. Proceedings of the National Academy of Sciences

Activated neurons in the cortex of a mouse following behavioural training.

19 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Dr Timothy Bredy Laboratory Head Associate Professor Thomas Burne

2014 Laboratory Members L–R/T–B: Thomas Burne, Suzy Alexander, Kyna-Anne Conn, Natalie Groves, Lachlan Harris, Pauline Ko, Emilia Lefevre, Aung Aung Moe, Chris Simpson, Karly Turner, Michelle Sanchez Vega. Not pictured: James Peak. Image: Touchscreen technology allows us to investigate cognitive performance in rodents using tasks that are similar to human tasks. In this paradigm the mouse learns to touch either horizontal or vertical white stripes to receive a sweet reward.

Translation of cognitive tasks for animal models of neuropsychiatric disorders Associate Professor Thomas Burne’s group stud- In 2014, the Burne group built on previous research and depression. Ongoing National Health and Med- ies brain development and behaviour in animal on low prenatal vitamin D (the ‘sunshine hormone’) ical Research Council funding allows the group models. The group is focussed on investigating to show that adult vitamin D deficiency is also to dissect the exact neural pathways involved in the underlying biological basis for schizophrenia, associated with alterations in behaviour, brain cognitive impairments of attentional processing in with the goal of finding public health interventions neurochemistry and receptor profiles. They have vitamin D deficient animals to model the cognitive that will alleviate the burden of this disease. The discovered that low vitamin D levels during adult- symptoms of schizophrenia. group has been exploring the impact of develop- hood affect the balance of excitatory and inhibitory The team has also created and validated a unique mental vitamin D deficiency on brain development, neurotransmitters in the brain, as well as altering cognitive task for rodents that mirrors the continu- the impact of adult vitamin D deficiency on brain cognitive behaviour in rodents. These results pro- ous performance task in humans. The group’s goal function and behaviour and, more recently, has vide the first evidence in mice to show that adult is to provide a novel tool for cognitive research in been establishing novel ways to assess cognitive vitamin D deficiency impacts on neurotransmitter rodents and to uncover more about the pathophys- behaviour in rodents. systems that are affected in a number of neuropsy- iology and drug treatment of cognitive symptoms chiatric conditions, including autism, schizophrenia in schizophrenia. Microglia (green) are measured to determine whether adult vitamin D deficiency dysregulates neuronal function within the hippocampus (blue).

RESEARCH 20 Laboratory Head Dr Allen Cheung

2014 Laboratory Members T–B: Allen Cheung, Ashvin Srinivasan. Not pictured: Rebecca Chan, Vinay Chandragiri, Zoltán Kósci. Image: A simulated rat uses a population of hypotheses to determine its location by combining noisy information with a ‘mental map’.

Computational theory of space and the brain The core research of Dr Cheung’s laboratory is vector between the starting location and current These unexpected results highlight the importance aimed at understanding the fundamental brain location. This form of navigation is prone to noise, of mental maps for navigation, the need for great computations required for spatial navigation. which leads to errors in navigation. It has long care in interpreting experimental results obtained Spatial navigation is one of the oldest and most been assumed that animals must use external inside any arena, and opens up new avenues to widespread brain functions in the animal kingdom. cues to correct for such errors. Surprisingly, the study the mammalian spatial memory system. The cells, circuits and computations required for Cheung laboratory recently found that external Collaborative projects are being planned at QBI animals to search for resources, return home, and cues are not always necessary. In fact, in a wide to test novel and important theoretical predictions go back to those resources later are subjects of range of bounded environments, an animal can arising from this work, in both humans and rats. intense research worldwide. theoretically combine a ‘mental map’ with noisy Research from the Cheung laboratory was pub- self-motion cues to accurately track its location, Path integration is one strategy used by verte- lished in the Proceedings of the National Academy without sight, sound, touch, smell or any other brates and invertebrates alike, and may be the of Sciences of the USA, PLOS Computational Biol- external sensory input. This applies to any space common ‘scaﬀold’ required for spatial navigation. ogy, and Journal of Theoretical Biology in 2014. with one-fold rotational symmetry, such as a kite- It is the process whereby estimated self-motion shaped or egg-shaped arena. is integrated over time to yield an approximate A mathematical representation of the activity of three simulated grid cells, encoding a kite-shaped space (red) and surrounding areas (black).

21 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Dr Allen Cheung Laboratory Head Professor Charles Claudianos

2014 Laboratory Members L–R/T–B: Charles Claudianos, Joon-Yong An, Stephanie Biergans, Ming-Yu Chen, Alexandre Cristino, Nivetha Gunasekaran, Aoife Larkin, Ramesh Narayanan, Michelle Watts, Sarah Williams. Image: Immunostaining of neuroligin 2 (orange/yellow) and overlapping RNA expression of embedded miR-932, associated with learning and memory integration regions (mushroom bodies) of the bee brain. DNA staining of cell bodies is shown in blue/purple. Senses and synapses

The development of the nervous system Current work involves genome sequencing of Key research findings: occurs in two ways: that which is deter- families affected by autism spectrum disor- • First to show that the sense of smell (olfactory receptor mined by our genetic program, helping der (ASD) to identify risk genes that are often expression) is regulated by long-term memory formation to direct cells to replicate and differenti- involved with nerve cell interaction. These mol- (Claudianos et al. 2014, European Journal of Neuroscience; ate, producing neurons that can project ecules are being characterised using human Faculty 1000 publication). to and connect with other neurons and neuronal cells, and aberrant cellular functions • Whole genome (exome) sequencing of Australian families innervate muscle and tissues typical of a including changes in nerve cell connections with ASD confirms the AXASTM model (Cristino et al. 2014, developing fetus; and that which requires (affecting neuronal projections and synapses) Molecular Psychiatry) can be used to predict genetic risk the same genetic program to respond to are helping to measure the impact of human of autism. environmental stimuli, learn, acquire and DNA variations. The laboratory also examines • First to show that DNA variants inherited from parents with recall memory and is subject to constant the biological relevance of genes and gene reg- a broader autism phenotype (BAP) have a significant asso- cellular/neuronal remodeling throughout ulation, including epigenetic mechanisms such ciation with ASD (An et al. 2014, Translational Psychiatry). life. Within this framework the Claudianos as methylation and microRNA, on brain plasticity. group works to understand the biological Due to its range of sophisticated behaviours • First to show that non-coding RNAs (neuroligin-associated A hypothetical network of 4,000 genes associated with basis of neurodevelopmental disorders and documented brain plasticity, the honey- miR-932) target the key development molecule actin and mental health disorders including autism spectrum dis- such as autism. bee is used by the Claudianos laboratory as a affect learning and memory (Cristino et al. 2014, Nature order, X-linked intellectual disability, attention deficit neurobiological model. Communications). hyperactivity disorder, and schizophrenia.

RESEARCH 22 Laboratory Head Associate Professor Helen Cooper

2014 Laboratory Members L–R/T–B: Helen Cooper, Ka Wai Foc, Michael Langford, Vanessa Lanoue, Natalie Lee, Conor O’Leary, Loc duyen Pham, Amanda White, Nicole Wilson. Image: Representative image of the actin cytoskeleton at the site of junctions in polarised epithelial cells, acquired using super-resolution structured illumination microscopy (SIM). Image by Natalie Lee.

Molecular mechanisms that regulate new neurons in the brain The goal of the Cooper laboratory is to understand The Cooper group has discovered that the stem The six layers of the adult cortex are comprised the fundamental molecular and cellular biological cell receptor neogenin is essential for maintaining of distinct pyramidal neuron subtypes that work processes within the neural stem cell niche that the integrity of the cortical stem cell niche. They together in complex neural networks to shape govern the development of the neocortex. In found that neogenin is a key regulator of neural cognitive and behavioural outcomes. This raises the embryonic cortex, neural stem cells undergo stem cell division as it closes down the cell cycle the intriguing question of how different subpop- self-renewing divisions or switch to asymmetric and encourages neuronal differentiation. Shutting ulations adopt their unique identities. Members divisions to generate new neurons. Understanding down neogenin signalling in the embryonic mouse of the Cooper laboratory have identified a new this critical decision-making process is of major leads to disruption of cortical development. Strik- signalling pathway activated by the Ryk receptor, importance as an imbalance between stem cell ingly, these phenotypes closely parallel those seen which promotes the acquisition of certain layer-spe- and neuron production is causative for cortical in humans, thereby implicating neogenin in the cific identities while suppressing other subtype malformations and has also been linked to autism, aetiology of cortical malformations. identities. Ryk mutations lead to an imbalance in intellectual disability and schizophrenia. neuronal subtypes, suggesting a link to intellectual disability.

The birth of new neurons (green) in the hippocampus.

23 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Associate Professor Helen Cooper Laboratory Head Associate Professor Elizabeth Coulson

2014 Laboratory Members L–R/T–B: Elizabeth Coulson, Zoran Boskovic, Marie Camara, Georg Kerbler, Dusan Matusica, Lei Qian, Bree Rumballe, Aanchal Sharma, Toni Turnbull. Not pictured: Mirela Wagner. Image: The hippocampus of a mouse model of Alzheimer’s disease showing accumulations of the amyloid-β protein, known as amyloid plaques (green puncta).

Understanding the aetiology of Alzheimer’s disease The Coulson laboratory is investigating why certain The Coulson group, in collaboration with scien- using positron emission tomography; PET imaging). neurons die in Alzheimer’s disease (AD) and how tists from the CSIRO, has developed a method This correlation occurred even in a group of people that affects cognition. Their work focusses on the to measure basal forebrain loss in humans using without cognitive impairment but who are consid- p75 neurotrophin receptor and its role in neuronal magnetic resonance imaging (MRI). In a population ered susceptible to developing dementia. Indeed, loss, particularly nerve cell degeneration that occurs of more than 200 elderly subjects, they found that by assessing the entire group longitudinally they in the basal forebrain. basal forebrain atrophy occurs early in AD and is found subjects with basal forebrain atrophy were correlated with cognitive impairment. They are more likely to undergo cognitive decline over the Basal forebrain neurons are important for learning now testing whether the MRI method can be used subsequent 18 months. Importantly parallel, studies and memory, and post-mortem studies show they to predict which AD patients are most likely to ongoing in the Coulson laboratory using mouse can be selectively lost in AD. The current treatment get benefit from the currently available AD drugs. models of AD indicate that basal forebrain loss for AD patients targets the function of basal fore- might induce increased amyloid-β production, and brain neurons. However, significant loss of these In addition, they found that basal forebrain loss therefore degeneration of these neurons may be a neurons has already occurred in the majority of AD is correlated with the development of another AD very early aetiological factor in the development patients prior to treatment. Because these drugs hallmark—amyloid-β plaque deposition (measured of the disease. Cholinergic neurons in a mouse basal forebrain labelled are only efficacious while the neurons are alive, it with a histological stain (top) and immunofluorescence is not surprising the treatment is of limited value (bottom). to most patients.

RESEARCH 24 Laboratory Head Associate Professor Ross Cunnington

2014 Laboratory Members L–R/T–B: Ross Cunnington, Jeﬀ Bednark, Megan Campbell, Yuan Cao, Veronika Halász, Jessica McFadyen, Vinh Nguyen, Kelsey Palghat, Simmy Poonian, Natalie Rens, Thomas Shaw, Chase Sherwell. Image: Mirroring activity in the visual and motor areas of the brain as people observe and imitate hand actions.

Brain processes for action, mirroring, and empathy The Cunnington laboratory focusses on the brain and control of voluntary movement. The group is same actions or states in others. Through the new processes involved in planning and preparing also combining MRI brain imaging with concurrent Australian Research Council Science of Learning for our own voluntary actions, as well as neural measurement of brain activity using electroen- Research Centre, the group is examining the ‘mirroring’ processes that are important for our cephalography (EEG). This work has revealed the mirroring or synchrony of biological markers of ability to perceive and understand others’ actions, crucial role of brain areas known as the supple- brain states between children in school classrooms, intentions, and emotional states. mentary motor area (SMA) and cingulate cortex examining how shared engagement between in movement planning processes occurring over children, down to the level of their mirrored neu- Research from the group is examining brain 1–2 seconds prior to movement initiation. rological or brain states, may contribute to learning processes important for the planning and co-ordi- in group co-operative activities. Other research nation of voluntary movement before its initiation. Other research in the group examines mirroring of the group is examining neural mirroring and Using the new 7 Tesla MRI scanner at UQ, the group processes in the brain, whereby brain activity brain processes important for empathy and the is examining the function of the ﬁne circuitry of normally associated with ﬁrst-hand experience neural factors that might lead us to empathise deep regions of the brain, known as the basal gan- of actions, sensations, and emotions appears to more strongly with some people over others. glia, which are crucial for higher-order planning be mirrored in our brain when we observe the

Brain areas important for timing and anticipation in the prefrontal cortex and basal ganglia.

25 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Associate Professor Ross Cunnington Laboratory Head Associate Professor Darryl Eyles

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2014 Laboratory Members L–R/T–B: Darryl Eyles, Suzy Alexander, Asad Ali, Xiaoying Cui, Lachlan Ferguson, Pauline Ko, David Kvaskoﬀ, Emilia Lefevre, Leon Luan, Aung Aung Moe, Kathie Overeem, Renata Pertile, Alice Petty, Henry Simila. Not pictured: Stephenie Vuillermot. Image: Vitamin D reverses social interaction deﬁcits and blocks hyperlocomotion in response to amphetamine in a Maternal Immune Activation animal model of schizophrenia.

Vitamin D deficiency, autism and schizophrenia The Eyles laboratory focusses on how risk factors Schizophrenia is closely associated with abnor- in adult offspring. With continual National Health for schizophrenia, such as developmental vitamin malities in dopamine transmission. The group’s and Medical Research Council and now National D (DVD) deficiency and maternal immune acti- work in DVD deficient animals confirms there are Institutes of Health funding success in 2014, the vation, change the way the brain develops. The early abnormalities in dopamine development group intends to expand the scope of its existing group has developed an extremely sensitive LC/ and turnover, and its work in 2014 using human animal model in two critical ways. Firstly, the group MS/MS assay for vitamin D species in blood spot cell systems describes for the first time the direct will examine the effect of varying the duration and cards. This assay allowed the 2010 landmark study control vitamin D exerts over dopamine produc- level of DVD deficiency on brain development implicating low maternal levels of vitamin D as a tion via the vitamin D receptor. The group’s work and function. Secondly, the group will examine risk factor for schizophrenia to be conducted. The represents a synthesis of the two major theories whether abnormalities in the ontogeny of dopa- group is now examining the relationship between of schizophrenia, the ‘dopamine hypothesis’ and mine systems observed in DVD deficient animals DVD deficiency and autism with five international the ‘neurodevelopmental hypothesis’, into the are shared by other prominent animal models of Based on the intensity of tyrosine hydroxylase (TH) collaborations, aiming to develop new ways to ‘dopamine ontogeny hypothesis of schizophrenia’. this disease. Promising initial data indicates that expression we have isolated dopamine neurons from measure other important vitamin D metabolites the active vitamin D hormone can suppress many For 15 years the Eyles group has explored the role the developing Substantia Nigra (SN) and Ventral in blood and brain. schizophrenia-relevant phenotypes in other animal of vitamin D in the developing brain and how DVD Tegmental Area (VTA). This will now allow us to examine models. the ontogeny of gene–expression in animal models of deficiency may affect brain function and behaviour abnormal dopamine neuron development.

RESEARCH 26 Laboratory Head Professor Geoﬀrey Goodhill

2014 Laboratory Members L–R/T–B: Geoffrey Goodhill, Lilach Avitan, Brendan Bicknell, Kelsey Chalmers, Richard Faville, Nicholas Hughes, Elizabeth Kita, Margaret Maallo, Huyen Nguyen, Zac Pujic, Biao Sun, Daniel Sutherland. Not pictured: Philip Dyer. Image: Cells in the zebrafish brain labelled with a fluorescent calcium indicator.

Computational, systems and developmental neuroscience Professor Goodhill’s laboratory is interested in how the significance of these changes for either the The group is also using fluorescent labelling tech- brains process information, particularly during sensory or motor roles of growth cones is mostly niques to visualise the simultaneous activity of development. This includes how growing nerve unknown. Sophisticated mathematical techniques many neurons in the developing zebrafish brain fibres (axons) use molecular cues to make guidance for characterising shape in general have been in response to simple visual stimuli. By using decisions, how map-like representations of visual adapted to develop a more quantitative under- mathematical techniques from statistics and infor- inputs form in the optic tectum and visual cortex, standing of the role growth cone shape plays in mation theory, it is then possible to predict how the and how these maps code sensory information. The effective axon guidance. In 2014 the laboratory was zebrafish could optimally decode these patterns of laboratory is using a combination of experimental, awarded a National Health and Medical Research activity in order to determine what visual stimulus mathematical and computational techniques. Council Project grant to continue this work. was actually present. A better understanding of neural decoding is important for optimising the One area of focus is how nerve fibres are guided Once nerve fibres have reached their targets, design of brain–computer interfaces. In 2014 the by molecular gradients to find appropriate targets connections are refined by neural activity. The laboratory was awarded an Australian Research in the developing nervous system. The laboratory laboratory recently developed new statistical Council Discovery grant to continue this work. recently investigated the shape of growth cones, methods based on Gaussian process regression the structures at the tip of developing axons. This to discover new ways in which the pattern of visual morphology is complex and highly dynamic but stimulation early in life influences brain structure. Cultured neurons growing in a novel micro- fluidics chamber.

27 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Professor Geoﬀrey Goodhill Laboratory Head Professor Jürgen Götz

2014 Laboratory Members L–R/T–B: Jürgen Götz, Siân Baker, J Bertran-Gonzales, Liviu Bodea, Nadia Cummins, Linda Cumner, Xia Di, Harrison Evans, Jasmin Galper, Robert Hatch, Gerhard Leinenga, Jing Lu, Miriam Matamales, Rebecca Nisbet, Tishila Palliyaguru, Zala Skrbis. Not pictured: Chuanzhou (Joe) Li, Chang (Sydney) Liu, Juan-Carlos Polanco. Image: Newly synthesised proteins ﬂuorescently labelled with click chemistry in transgenic mouse ﬁbroblasts (Ullrich et al., Nature Protocols, 2014).

Alzheimer’s disease—from basic mechanisms to a therapy With an increasing life expectancy, the number 2014 has seen significant funding from the State revealed as a therapy for AD and FTD, with ongoing of Australians suffering from Alzheimer’s disease and Federal Government and ongoing funding efforts focusing on so-called single-chain antibod- (AD) and related dementias including frontotem- from the Australian Research Council and the ies. Collaborative work with Hannah Nicholas (The poral dementia (FTD) is dramatically increasing, National Health and Medical Research Council University of Sydney) in the roundworm C. elegans from 320,000 currently to almost one million by (including a Program Grant on FTD and motor addressed the role of a tau homologue in neuronal 2050. In the Götz laboratory, which forms part neuron disease). Strategic decisions were the integrity and life-span, and established a novel of the Clem Jones Centre for Ageing Dementia recruitment of the electrophysiologist Robert click chemistry method to visualise and identify Research (CJCADR), there are three major streams Hatch from a leading epilepsy laboratory, and newly synthesised proteins in ageing and under of research: (i) understanding disease initiation and Liviu Bodea (Peter Hilton Research Fellow) from an conditions of stress. progression at a molecular and cellular level using overseas laboratory working on the role glial cells We have further established QBI’s first TALEN-based cellular and animal models, (ii) understanding the have in neurodegeneration. Research highlights edited mouse genome in order to understand the role that proteins implicated in dementia have in include the discovery of what dictates the local- trafficking of tau into dendritic spines. Also, excit- physiological processes, and (iii) the development isation of tau (which forms clumps in AD brains) ingly, we have established a novel ultrasound-based The top image shows a neuron in culture. The boxed of novel therapies. in dendritic spines, and the role the kinase Fyn therapy that in the coming year will be combined area represents a dendritic branch with the enlarged has in this process. Tau-based immunisation was images revealing staining for cytoskeletal and cyoskel- with the delivery of antibodies. eton-associated proteins.

RESEARCH 28 Laboratory Head Associate Professor Massimo A. Hilliard

2014 Laboratory Members L–R/T–B: Massimo Hilliard, Justin Chaplin, Sean Coakley, Alessandra Donato, Sam Geraghty, Rosina Giordano-Santini, Casey Linton, Ellen Meelkop, Brent Neumann, Fiona Ritchie. Image: Injured axons of the nematode Caenorhabditis elegans and other invertebrate species are able to rejoin with their separated segments (shown here as fused electrical wires), preventing degeneration and restoring the original axonal tract.

Axonal development, regeneration, and degeneration: molecules & mechanism The Hilliard laboratory is interested in understand- or cargo-tracks of the cytoskeleton, these in vivo mechanisms responsible for the ROS-mediated ing how axons (nerve fibres conducting impulses results are consistent with emerging evidence in degeneration. The team has also uncovered an from the neuron) develop and are guided to their vitro that microtubules can provide critical signals axonal protective function for MEC-17, an α-tubulin targets. The group also investigates how the axonal for axon formation. acetyltransferase, which stabilises the cytoskeleton structure is maintained over time and how it can to allow proper transport of molecules and orga- The axon is the neuron’s longest process, but the be reconstituted after injury. Neurons are highly nelles throughout the axon (Cell Reports, 2014). mechanisms that allow it to maintain its structural polarised cells, with neurites, dendrites and an axon integrity, or facilitate repair following injury, remain Using laser-based technology to axotomise single forming distinct morphological and functional poorly understood. Reactive oxygen species (ROS) neurons in C. elegans, the Hilliard group has domains. How a neuron decides on the number are major neuronal damaging components gener- characterised neuronal regeneration in different of neurites to extend is not well understood. ated in a number of neurodegenerative conditions. classes of sensory neurons. In earlier work they Using C. elegans mechanosensory neurons as a In a collaborative project, the Hilliard group has demonstrated that axonal regeneration can occur model system, the Hilliard group has discovered developed an approach to generate ROS in selec- as a result of axonal fusion, when two separated MEC-7/β-tubulin, a component of microtubules, to After injury to the nervous system in the nematode tive classes of neurons, which makes it possible to axonal fragments re-attach and restore the original have a critical role in this process. In contrast to the Caenorhabditis elegans, an axon sprouts new growth determine, with a genetic approach, the molecular axonal tract. idea that microtubules are simple building blocks towards its detached segment; a membrane-tethered fluorophore is shown in red, and the cytoplasm green. Image by Casey Linton.

29 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Associate Professor Massimo A. Hilliard Laboratory Head Professor Tianzi Jiang

2014 Laboratory Members L–R/T–B: Tianzi Jiang, Yonghui Li, Cirong Liu, Tong Wu, Xianfeng Yang. Image: Abnormal mean diffusivity within the fimbria found by tractography based on diffusion magnetic resonance (dMRI) and correlated with behavioural performance of mice.

Mapping human and animal brain networks with neuroimaging Convergent evidence has shown that brain func- (DISC1) gene. Despite the fact that DISC1 is a In addition to findings in animal models, the lab- tions can manifest at different scales within brain promising risk gene for many mental illnesses oratory also made significant progress in human networks, and that the malfunctions associated associated with white matter abnormities and studies, particularly in the identification of Alzheim- with most psychiatric disorders are the result of disconnection syndromes, the roles of DISC1 er’s disease (AD) risk genes using neuroimaging faulty brain networks. The Brainnetome (www. in white matter development, oligodendrocyte markers. Using a novel hippocampal shape pheno- brainnetome.org) provides a foundation for inte- differentiation and myelination are unclear. By type derived from a computational neuroanatomy grating the multi-level network features obtained performing behavioural, high resolution ex vivo approach, the Jiang laboratory identified 18 PAK3 with various functional and anatomical brain imag- diffusion magnetic resonance (dMRI) and histolog- low frequency variants that have significant effects ing technologies. The Jiang laboratory is studying ical examinations on the same animal, the Jiang on β-amyloid production and the severity of AD basic theory, methodologies and algorithms laboratory identified significant dMRI-based abnor- symptoms via haplotypes, and have large effects underpinning the Brainnetome platform, and malities in the hippocampus and fimbria of DISC1 on late onset AD risk, particularly for males or the their applications in neurological and psychiatric mice that underwent adolescent isolation, an effect non-APOE ε4 population. This finding provides new Top: The elongated hippocampal shape phenotype diseases. that correlated significantly with specific behavioural insight into the mechanism of AD development, associated with Alzheimer’s disease (AD) risk. Bottom: and histological phenotypes. This suggests a gene– and has clinical significance due to the enrichment In 2014, one study on the mouse Brainnetome The effects of the AD risk genotype PAK3-RT on memory environment interaction may underlie a variety of of these variants in AD patients. (using the mini mental state examination) and amyloid-β focussed on the Disrupted-In-Schizophrenia-1 (Aβ) levels. neuropsychiatric disorders such as schizophrenia.

RESEARCH 30 Laboratory Head Professor Joe Lynch

2014 Laboratory Members L–R/T–B: Joe Lynch, Christine Dixon, Argel Estrada, Justine Haddrill, Sharifun Islam, Robi Islam, Angelo Keramidas, Suzanne Scott, Ming Shiuan Soh, Sahil Talwar, Yan Zhang. Not pictured: Kristin Sung. Image: Docked pose of 2,4,5-trimehtoxyamphetamine (TMA-2) binding to the GlyR. TMA-2 is a novel high aﬃnity modulator of GlyRs. Image by Talwar Sahil.

Discovering new drugs for inhibitory neurotransmitter receptors

The Lynch laboratory’s major research interest Chronic inflammatory pain is caused by prostaglan- As synaptic GABAARs and GlyRs are formed from concerns the molecular structure and function of dins modulating α3 GlyRs that are specifically found a wide variety of subunits, many isoforms are the glycine and GABAA receptor (GABAAR) chloride in pain sensory neurons in the spinal cord. These possible in vivo. Each isoform exhibits unique channels that mediate inhibitory neurotransmission ‘pain-modulated’ receptors represent a promis- pharmacological and physiological properties, and in the brain. The GABAAR is an important therapeu- ing therapeutic target for chronic pain, but the has a unique role in brain function. Until now, it tic target for sedative and anxiolytic drugs and the problem has always been to prevent the drugs has not been possible to investigate a particular glycine receptor (GlyR) has recently emerged as a from affecting other GlyRs elsewhere in the brain. isoform in isolation in neurons due to the huge therapeutic target for pain, spasticity, epilepsy and Following years of collaboration with a natural range of isoforms that are expressed simultane- tinnitus. The Lynch laboratory is discovering new product chemist (Rob Capon, from the Institute ously. The group has now developed techniques drugs active at these receptors and the molec- for Molecular Bioscience, UQ) to develop new α3 for reliably generating ‘artificial’ inhibitory synapses ular mechanisms by which their structures and GlyR-specific drugs, the group has succeeded in that incorporate the defined GlyR or GABAAR sub- functions are disrupted in hereditary neurological developing a drug with exquisite sensitivity and units of interest. This enables investigation of the disorders. specificity for α3 GlyRs, which exerts potent anal- effects of drugs on synaptic currents mediated by gesia in animal pain models. defined GABAAR or GlyR isoforms, and the effect Neuronal presynaptic terminals (green) forming ‘arti- that disease mutations have on the formation and ficial’ GABAergic synapses onto HEK293 cells (purple). function of both types of synapses. Green and purple labelling are for GAD65 and neuroligin-2, respectively. Image by Christine Dixon.

31 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Professor Joe Lynch Laboratory Head Dr Marie Mangelsdorf

2014 Laboratory Members L–R/T–B: Marie Mangelsdorf, John Baisden, Tim Butler, Sarah Furlong, Jing Zhao. Not pictured: He Ji, Damien Rank. Image: The TARDBP gene encodes the protein TDP-43, which displays abnormal pathology in most patients with motor neuron disease (MND). A mutation in TARRDBP is revealed using whole exome sequencing, comparing an unaﬀect person (top) to a patient with MND who carriers a mutated green ‘A’ nucleotide in their DNA (bottom).

Understanding the mechanisms of motor neuron disease using molecular genetics Dr Mangelsdorf is head of the Peter Goodenough The Mangelsdorf group has been using next gen- The group is also investigating the role of the RNA and Wantoks Research Laboratory, dedicated to eration sequencing to generate data from MND binding protein TDP-43 in MND. Most patients understanding the causes of motor neuron disease patients and controls. In collaboration with others with MND have abnormal TDP-43 in their neurons. (MND). MND is a neurodegenerative disease that from QBI (Professors Bartlett, Visscher and Wray), as The Mangelsdorf group is testing a new mouse occurs when motor neurons that control muscles well as Professors Matt Brown (TRI), Huji Xu (Shang- model of TDP-43 with the aim of revealing the degenerate. There is no cure and a person diag- hai) and Dongsheng Fan (Beijing), sequencing data effect of TDP-43 mutation on the RNAs it regulates. nosed with MND has a life expectancy of only from more than 600 cases from China has been Based on information previously generated by the three years. completed. In addition, the Mangelsdorf laboratory group from mouse models, the Hilliard group at is sequencing DNA from more than 100 patients QBI is studying TDP-43 mediated RNA transport A genetic basis for MND is suggested by families who have donated samples at the MND clinic at in C. elegans neurons to determine the role of this in which multiple people are affected, and several the Royal Brisbane and Women’s Hospital (funded cellular process in MND pathology. In collabora- genes that play a significant role in MND have been by the Motor Neurone Disease Research Institute tion with Associate Professor Peter Noakes (QBI identified. However the cause of ALS in ~35 per of Australia). Analysis of this data is underway and affiliate), who has collected muscle samples from cent of familial cases, and ~80 per cent of cases Illumina HiSeq™ Flowcells. Through massively parallel will help to uncover novel genetic contributions MND patients, the Mangelsdorf laboratory will also with no family history, remains unclear. sequencing, a single flow cell enables individual exomes to the disease. be investigating the RNAs regulated by TDP-43 in to be sequenced rapidly to uncover the genetic basis human samples using next generation sequencing. of motor neuron disease.

RESEARCH 32 Laboratory Head Professor Justin Marshall

2014 Laboratory Members L–R/T–B: Justin Marshall, Karen Cheney, Wen-Sung Chung, Fabio Cortesi, Yakir Gagnon, Alan Goldizen, Kyra Hay, Diana Kleine, Yi-Hsin Lee, Martin Luehrmann, Genevieve Phillips, Qamar Schuyler, Sara Stieb, Rachel Templin, Hanne Thoen. Not pictured: Santi Krisantini, Melody Puckridge, Anne Winters. Image: Golgi stain of a newly discovered amacrine cell in the visual pathway of stomatopod crustaceans.

Visual ecology—neuroscience in the real world A systems approach to sensory neuroscience is the interpreting the new language of polarisation com- the Springer Series in Vision Research, a new cor- aim of the Marshall laboratory. Working from the munication, use of colours and unconventional nerstone reference in visual neuroscience with outside in, visual ecology examines the biology colour vision systems and molecular mechanisms Professor Marshall as senior editor and co-series and physics of an organism’s habitat, how light behind colour vision in marine organisms. With founder with colleague Professor Shaun Collin of is guided through the eye’s optics to the retina, colleagues in the USA and UK, these areas are now The University of Western Australia. Communicat- the retinal molecules and design components that delivering bio-inspired solutions for imaging neural ing science to the public is important to the group absorb light, neural conduction of this information activity and the detection of cancer. and collaborations with local TV and radio, the BBC, to the brain, processing and behavioural outcomes Sir David Attenborough and Atlantic Productions Our comparative systems approach saw more driven by the brain and finally the different types gathered momentum, seeing the group central than 20 articles and five books published in 2014, of behaviour such as sexual, territorial or defensive. to several documentary series due out in 2016. including work appearing in Science, Current CoralWatch (the group’s environmental section) The laboratory’s mostly marine model animals are Biology, Proceedings of the National Academy of continues to grow as one of Australia’s leading extracted from the field and include crustaceans, Sciences of the USA and Proceedings of the Insti- citizen science groups, exploring new methods of fish and cephalopods. In 2014 this comparative tute of Electrical and Electronics Engineers. Visual science outreach and participation in more than drive delivered many discoveries in colour and Ecology, a much needed field update book, was a 80 countries. Colourblind reef squids enhance their eyesight using polarisation vision. Some core questions include highlight along with four edited volumes through polarisation vision to increase image contrast, and a range-finding mechanism to enable their fast strike.

33 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Professor Justin Marshall Laboratory Head Professor Jason Mattingley

— Increased integration Fronto-parietal network (trial-by-trial control) Cingulo-opercular network (task sets) Visual network Striatum Thalamus

2014 Laboratory Members L–R/T–B: Jason Mattingley, Oliver Baumann, Nicholas Bland, Luca Cocchi, Daina Dickins, Eve Dupierrix, Hannah Filmer, Marta Garrido, Michelle Hall, Luke Hearne, Oscar Jacoby, Marc Kamke, David Lloyd, Natasha Matthews, Claire Naughtin, Abbey Nydam, David Painter, Amanda Robinson, Martin Sale, Cooper Smout, Susan Travis, Lisa Wittenhagen. Not pictured: Amy Taylor, James Teng. Image: Large-scale brain network involved in cognitive problem-solving. Coloured disks represent diﬀerent brain regions and arrows show the functional links between them.

Understanding human brain function in health and disease Researchers in the Mattingley laboratory investigate In 2014, researchers in the Mattingley laboratory 2014 also saw a number of important milestones how the human brain gives rise to perception, cog- made several important discoveries. Graduate in the Mattingley laboratory. David Painter and nition and the control of movement, in health and student Amanda Robinson published a paper in Amanda Robinson were awarded their PhDs and disease. They are inspired by a desire to understand the Journal of Cognitive Neuroscience showing took up prestigious postdoctoral fellowships in how people use attention to prioritise information, that inhaled odours can modify how visual areas overseas laboratories. Postdoctoral fellow Martin whether from the sensory world or from internal of the human brain respond to familiar objects. Sale was awarded a National Health and Medical thought processes. They also investigate learning, This work has improved our understanding of how Research Council Project grant to examine whether with the aim of harnessing new discoveries from the various sensory areas of the brain integrate slow-wave neural oscillations can enhance brain the ﬁeld of neuroscience to enhance learning out- their activity. In other work, postdoctoral fellow plasticity, and Jason Mattingley and Marta Gar- comes across the lifespan. A particularly important Luca Cocchi published a paper in Cerebral Cortex rido were part of a successful bid to the Australian part of the research involves understanding how showing how frontal regions of the brain establish Research Council to establish a new $20 million perceptual and cognitive processes can be impaired functional connections with other areas during Centre for Integrative Brain Function. in brain disorders such as stroke. They employ a complex problem-solving tasks. And postdoctoral range of approaches to investigate these ques- fellow Hannah Filmer published a review in Trends Transcranial electrical stimulation of the brain. Current tions, including behavioural tests, imaging and in Neurosciences on a new method for non-invasive travelling between electrode pads (blue) changes the brain stimulation methods. brain stimulation. likelihood of neurons ﬁring (gold).

RESEARCH 34 Laboratory Head Professor John McGrath

2014 Laboratory Members L–R/T–B: John McGrath, Helen Gooch, Amy Heﬀernan, Henry Simila, Anna Vinkhuyzen. Not pictured: Peter Josh. Image: ‘Faces’ by Francesca Roberts. Crayon and pencil on paper, from the Queensland Centre for Mental Health Research Art Collection.

The prevention and treatment of schizophrenia The aim of the McGrath laboratory is to explore risk Previously in 2013, Professor McGrath was awarded extending studies related to vitamin D in inter- factors that are linked to schizophrenia and other a prestigious National Health and Medical Research national datasets by exploring gene–environment mental disorders. They focus on non-genetic fac- Council John Cade Fellowship in Mental Health interactions. tors that are potentially modiﬁable. In recent years Research. These funds have allowed the group to In collaboration with Associate Professor James the team has been examining the impact of low explore a wider range of modiﬁable risk factors Scott (UQ Centre for Clinical Research), the McGrath vitamin D (the ‘sunshine hormone’) during early (e.g. infectious agents, stress, cannabis, vitamin D), laboratory commenced a clinical trials program brain development and on adult brain function. a more diverse range of brain-related outcomes related to improving outcomes in people with Early In collaboration with Associate Professors Darryl (e.g. prenatal and neonatal brain growth, child- Psychosis. In collaboration with hospitals and clinics Eyles and Thomas Burne at QBI, they have devel- hood neurocognition, autism, schizophrenia, other in South-East Queensland, the team will examine oped animal models to examine the impact of low mental disorders), and a wider range of epidemi- new treatments using randomised controlled trials. vitamin D during gestation on brain development. ological samples (in collaboration with national The group has established a new research program and international groups). New projects include an with Professor Pankaj Sah and Dr Helen Gooch to international study related to psychotic experiences explore links between vitamin D and voltage-gated in the general community (Harvard University and calcium channels. 19 other universities). The group has also been Primary cortical neuronal cultures, to demonstrate the expression of L-type voltage gated calcium channels (red) within inhibitory GABAergic neurons (green).

35 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Professor John McGrath Laboratory Head Professor Frederic Meunier

2014 Laboratory Members L–R/T–B: Frederic Meunier, Adekunle Bademosi, Rachel Gormal, Callista Harper, Ravikiran Kasula, David Kvaskov, Regine Low, Sally Martin, Nika Mohannak, Vinod Narayana, Tam Hong Nguyen, Andreas Papadopulos, Vanesa Tomatis, Tong (Iris) Wang. Image: Secretory vesicles are entangled in a dense mesh of actin ﬁlaments underneath the cell membrane, ready to release their hormone or neurotransmitter content in response to stimulation.

Unravelling neuronal communication and survival 2014 was a great year for the Meunier laboratory, lead to worsened outcomes. In a study published The team has continued to pursue its work into the including the award of an Australian Research Coun- in Nature Communications, the laboratory, in col- mechanism of neuroexocytosis, discovering that a cil Discovery Project grant and the publication of laboration with several others from London and human mutation of the protein MUNC18-1, linked five peer-reviewed publications. Hamburg, showed that the PI3-kinase δ inhibitor to early infantile epileptic encephalopathy, potently CAL-101 provided a clear neuroprotective effect by increased its ubiquitination and proteasomal deg- As part of the Clem Jones Centre for Ageing Demen- controlling the release of the pro-inflammatory radation leading to a temperature-sensitive defect tia Research (CJCADR), the Meunier laboratory cytokine Tumor Necrosis Factor-α from microglia. in exocytosis (Cell Reports). This paper was high- made a breakthrough in the fight against stroke. CAL-101 was effective in improving post-stroke lighted in Prime F1000. The group also unravelled a Claiming five million lives each year, it is the second recovery in mice, and it was still effective up to novel mechanism allowing neurosecretory vesicles biggest killer after ischaemic heart disease. The three hours after the clot was removed and blood to be directed towards the plasma membrane in socio-economic burden is enormous, as those who started flowing. This suggests that CAL-101 or similar an activity-dependent manner (PLOS ONE). survive stroke have to live with profound neurologi- drugs could be given in conjunction with currently cal deficits. Current treatments for ischaemic stroke used drugs such as tPA. The study had wide media are inefficient and solely rely on removing blood The basal cortical actin network of a bovine chromaf- and social media coverage including an article in clots in the brain, which activate inflammation and fin cell undergoes remodeling in preparation for bulk The Conversation. endocytosis. Act0-myosin II rings form around the neck of budding endosomes.

RESEARCH 36 Laboratory Head Professor Bryan Mowry

2014 Laboratory Members L–R/T–B: Bryan Mowry, Emma Byers, Ilvana Dzaﬁc, Cheryl Filippich, Javed Fowdar, Bill Mantzioris, Andrew Martin, Samuel Nayler, Kalpana Patel, Sathish Periyasamy Chikako Ragan, Heather Smith. Image: Glial cells (red) are being studied to determine whether there are diﬀerences in schizophrenia (neurons are green).

Exploring latest genetic findings The Mowry laboratory aims to identify and phenotyping of schizophrenia patients with major schizophrenia patients and controls, in order to functionally characterise susceptibility genes for copy number variations, and comparing patients establish an in vitro model of disease. schizophrenia and related disorders. The group with a matched sample of healthy individuals; Highlights during the year included (i) National aims to achieve this by combining genome-wide (iii) GWAS in homogeneous Indian and Sarawak Health and Medical Research Council funding association studies (GWAS), DNA sequencing populations, and relating the results to the latest (2014–16) to conduct a whole exome sequencing and transcriptome profiling with neuropsycho- European study results; (iv) transcriptome-wide study of families to identify de novo and inherited logical testing and neuroimaging in people with analysis of small non-coding RNAs in post-mortem mutations contributing to disease; (ii) contributions schizophrenia. brain samples from schizophrenia patients and to the latest Psychiatric Genomics Consortium unaffected individuals; (v) targeted resequencing of Current studies include: (i) the recruitment of schizophrenia GWAS, which has identified more a previously identified schizophrenia linkage region a large Indian case-control and family cohort than 100 genetic susceptibility loci (Nature, 2014). on chromosome 1 in an Indian case-control sample, in collaboration with Dr Rangaswamy Thara The group also published a review in Schizophre- using QBI’s next-generation sequencing facility; (vi) (Schizophrenia Research Foundation, Chen- nia Bulletin on the role for iPSCs in schizophrenia derivation of neuronal cells using induced pluri- nai); (ii) neuroimaging and neuropsychological research. potent stem cell (iPSC) technology in a subset of Functional magnetic resonance imaging (fMRI) activation differences across random (warm colours) and theory of mind (cool colours) animations in patients with schizophrenia and healthy controls.

37 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Professor Bryan Mowry Laboratory Head Mr Geoﬀrey Osborne

1216 DAPI CHO #2.fcs:R0 104

103

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100 100 101 102 103 104 Green Fluorescence 0 0 10k 20k 30k 40k 50k 60k Relative fuorescemce intensity

2014 Laboratory Members T–B: Geoffrey Osborne, Virginia Nink. Image: The analysis of DNA and specific RNA’s from sub-populations of cells is becoming increasingly important. The laboratory has been developing combined methods based on accurate sorting of cells from different phases of the cell cycle (main image: resting cell phase coloured blue for example) and then analysing expression levels of specific microRNA’s using a fluorescent barcoded particle approach (inset: green and yellow fluorescence barcode population binding microRNA’s) from different phases of the cell cycle.

Implementing novel approaches to solve fundamental problems As Director of Flow Cytometry for both QBI and accurate determination of the number of cells with the laboratory actively pursued in 2014. MicroRNAs the Australian Institute for Bioengineering and characteristics of interest by flow cytometry has have been shown to be critical regulators of cell Nanotechnology, Mr Geoffrey Osborne leads a not had widespread uptake in the research set- growth and differentiation in glioblastoma, the team that provides crucial cell sorting and analysis ting. The group published a paper showing that a aggressive form of brain tumour that has been a services to researchers both within QBI and across simply volumetric method provides results that are research focus of this laboratory for a number of the broader university. The laboratory specialises comparable to those obtained using commercial years. Using a novel approach based on multiplexed in the analysis and separation of cells derived from counting beads, or those obtained using a ‘gold nanorod probes, the laboratory has shown that it a variety of sources such as solid tissue, blood and standard’ haematology analyser. The implication of is possible to detect varying microRNA levels in cultured cell lines. this work is that now absolute counts of numbers human tumour samples. of particular cells present in blood or tissue can be The wide diversity of scientific areas in which flow Mr Geoffrey Osborne holds a joint appointment quantified and loss or gain related to disease, or in cytometry can be applied has resulted in a number with the Australian Institute for Bioengineering and response to stimuli, can now be readily quantified. of collaborative projects. One critical area that has Nanotechnology. The gonometric nozzle assembly in a cell sorting flow been addressed in the past year is the defining of The quantification of particular microRNAs using cytometer. This feature allows to the use of low operat- absolute cell counts by flow cytometry. To date, a novel flow cytometry assay is another area that ing pressures that improves assay sensitivity and allows the generation of results such as those on the right.

RESEARCH 38 Laboratory Head Dr Michael Piper

2014 Laboratory Members L–R/T–B: Michael Piper, Lachlan Harris, Tracey Harvey, Evelyn Heng, Chantelle Reid, Diana Vidovic. Not pictured: Elise Horne. Image: Study of the biology of proliferating neural stem cells within the cortex by determining where dividing neural progenitor cells are found (diﬀerent progenitor cells are labelled here with purple and green ﬂuorescent markers), and the genes that control their division.

Regulation of stem cell differentiation Neural stem cells provide the building blocks from The Piper laboratory studies the genes that control the embryonic and adult brain are regulated by a which the neurons and glia of the mature brain neural stem cell differentiation in both the devel- family of transcription factors known as the nuclear are generated. During development, the control oping and adult brain. To do this it uses mouse factor one family (NFI). They have shown that NFIB of how these stem cells either self-renew or dif- model systems and in vitro cell culture paradigms is critical for the formation of the hippocampus, a ferentiate is crucial to the correct formation of the to investigate the key processes behind the biol- key site for learning and memory within the brain brain. Moreover, neural stem cells are also found ogy of neural progenitor cells, and to reveal the (Piper et al., Journal of Neuroscience, 2014). Fur- in the adult brain, where they provide ongoing genetic hierarchy that controls neural progenitor thermore, the group has shown that another NFI neurogenesis throughout life. Understanding how cell differentiation. Moreover, the Piper laboratory family member, NFIX, is also required for the for- these neural stem cells are regulated is critical if we is also applying these findings to investigate dis- mation of the hippocampus (Heng et al., Cerebral are to understand the normal trajectory of brain orders such as glioma, which are characterised by Cortex, 2014). Current work in the Piper laboratory development, and can also provide insights into unrestrained stem cell proliferation. is aimed at further elucidating the targets of NFI developmental disorders and disease. transcription factors, and how misregulation of The group’s recent findings reveal how neural this transcription factor family can culminate in stem cell development and differentiation within brain cancer.

Expression of the neural progenitor cell markers PAX6 (red) and TBR2 (green) in the developing mouse cortex.

39 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Dr Michael Piper Laboratory Head Dr Judith Reinhard

2014 Laboratory Members L–R/T–B: Judith Reinhard, Stephanie Biergans, Ming-Yu Chen, Alexandre Cristino, Shao-chang Huang, Homayoun Kheyri, Aoife Larkin, Morgane Nouvian, Amanda Robinson. Image: Cross-section of a honeybee antenna showing expression of olfactory receptor Or151 in neurons (red/orange/yellow).

Olfactory plasticity: how the brain makes sense of scents Researchers in the Reinhard laboratory investigate However, how we perceive different scents, aromas This research demonstrates for the first time that how the brain processes sensory information and and flavours changes throughout our lives, which the ability to smell different things is experience-de- translates it into behavioural activity, thus linking can affect our preferences for different foods or pendent and modulated by scent conditioning. The brain function to behaviour. In particular, the group beverages. The Reinhard laboratory has led an inter- findings may help explain the wide variability of studies the mechanisms underlying learning of national study that has boosted understanding of smell perception in humans and the neurological odours, and how olfactory experiences and mem- this process, by showing that olfactory memory mechanism underlying the common phenomenon ories modulate brain function. The laboratory uses formation plastically regulates olfactory receptor of ‘acquired taste’, where repeated sensory expe- insect model systems in combination with human expression in the sensory periphery. Using an insect rience with a flavour or aroma leads to perceptual studies and integrates behavioural approaches with model with a superb capacity for learning odours, changes. This knowledge will provide an enormous physiological and molecular approaches. the honeybee, they showed that formation of a insight for understanding flavour and aroma per- particular odour memory in the brain modulates ception, and how our sensory experiences shape Smell memories are some of the most salient that expression of the respective receptor molecules in our preferences. The study, which was published humans form in their lives, and a mere whiff of an the sensory periphery, the bee’s antennae. in the European Journal of Neuroscience, was rec- odour can trigger recall of long-forgotten events. ommended by the Faculty of 1000 and highlighted by Global Medical Discovery. Segment of a honeybee antenna showing expression of olfactory receptor Or151 in neurons.

RESEARCH 40 Laboratory Head Professor Linda Richards

2014 Laboratory Members L–R/T–B: Linda Richards, Gonzalo Almarza, Jens Bunt, Kok-Siong Chen, Tim Edwards, Sinead Eyre, Laura Fenlon, Ilan Gobius, Zelan Hu, Peter Kozulin, Jonathan Lim, Laura Morcom, Annalisa Paolino, Thomas Pollak, Rodrigo Suárez. Not pictured: Julie Webster. Image: Diﬀusion MRI of a platypus brain showing bilateral cortical connections crossing through the anterior commissure. Image by Rodrigo Suárez.

Mechanisms of brain development required for brain function The laboratory is focussed on understanding early of the corpus callosum. A number of collaborative Awards to laboratory members included the UQ brain development and the mechanisms that lead projects also came to fruition with groups in the Academic Medal to BSc(Hons) student Jonathan to correct brain wiring. They are interested in how USA, China and Europe, which resulted in high Lim. PhD student Laura Fenlon was awarded a such mechanisms may be disrupted during devel- impact publications on mechanisms underlying competitive student presentation prize (second opment and how this aﬀects the cognitive outcome brain wiring in mouse models of human congenital place in the QBI graduate student symposium) of individuals. malformations. A clinical review on the genetics and the QBI prize for best student paper (co-ﬁrst and developmental mechanisms related to human place), and two competitive travel scholarships. Dr 2014 was a very productive year for the labora- malformations of the corpus callosum with special- Rodrigo Suarez was awarded two travel scholar- tory. One highlight was a paper showing that ist-physician colleagues in San Francisco was also ships to attend a conference on brain evolution in a balance of activity between the two hemi- published (Edwards et al., Brain, 2014). Toledo, Spain from the International Brain Research spheres of the brain is important for its wiring Organisation (IBRO) and Contributing to Australian (Suárez, Fenlon et al., Neuron, 2014). The group The laboratory has employed a wide variety of Science and Scholarship (CASS). Finally, Dr Jens is now investigating what aspects of activity are sophisticated techniques, from genetics and gene Bunt received independent project funding from important for brain wiring as this may provide manipulation in animal models to high resolution the Brain Foundation for his work on brain cancer. In naturally acallosal animals, such as marsupials, insight into the causes of developmental dis- microscopy and multimodal magnetic resonance cortical neurons (green) send axons to the opposite orders of brain wiring such as malformations imaging. hemisphere via the anterior commissure. Image by Rodrigo Suárez.

41 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Professor Pankaj Sah

2014 Laboratory Members L–R/T–B: Pankaj Sah, Eleanora Autuori, Suzanne Campbell, Christine Dixon, Amu Faiz, Arezoo Fallah, Andrea Giorni , Helen Gooch, Sarah Hunt, Roger Marek, John Morris, Chris Nolan, Madhusoothanan Bhagavathi Perumal, Margreet Ridder, Petra Sedlak, Peter Stratton, Cornelia Strobel, Robert Sullivan, Yajie Sun, Fabrice Turpin, François Windels, Li Xu, Shanzhi Yan. Image: Neurons of the auditory cortex (AC, green) were genetically manipulated to express a light sensitive protein. This allows to control their activity using laser light with a very precise temporal and spatial resolution.

Neural circuits and mechanisms underpinning learning and memory The Sah laboratory studies the physiological and circuits. The group has mapped the circuits that For the human studies, Professor Sah collaborates molecular mechanisms that underlie behaviour, provide auditory and noxious information to the with Professor Peter Silburn and Dr Terry Coyne learning and memory formation. Using a combina- amygdala, and studied the circuits that connect (UQ Centre for Clinical Research) to study neural tion of electrophysiology and molecular techniques, the amygdala with the prefrontal cortex and activity in the human brain in patients undergoing in conjunction with behavioural studies, the lab- hippocampus. neurosurgery for deep brain stimulation. These oratory seeks to understand the neural circuitry recordings are revealing the activity in the human In collaboration with Professor Joe Lynch at QBI, that underpins learning and memory formation in brain in a range of movement disorders, such as the group is exploring the molecular identity of animal models. These studies are complemented Parkinson’s disease, essential tremor and Tourette’s receptors that are present at inhibitory connections by electrophysiological recordings and behavioural syndrome. In 2015, the group will be involved in in the amygdala. In the last year they have concen- analysis in humans. The laboratory focuses on the a clinical trial for the treatment of obsessive com- trated on the properties of synaptic γ-aminobutyric part of the brain called the amygdala. The group pulsive disorder. (GABA) receptors that contain γ1 subunits. These uses viruses to deliver optogenetic constructs to receptors are enriched in speciﬁc circuits in the neurons in deﬁned regions, and then records the amygdala and could be targets for the development electrical activity in acute brain slices to study of new anxiolytic drugs. The surgical implantation of a recording electrode is the properties of the connections in these neural part of the procedure used for the the treatment of Parkinson’s disease by deep brain stimulation.

RESEARCH 42 Laboratory Head Professor Mandyam Srinivasan

2014 Laboratory Members L–R/T–B: Mandyam Srinivasan, Julia Groening, Michael Knight, Nikolai Liebsch, Ingo Schiﬀner, Dean Soccol, Reuben Strydom, Gavin Taylor, Saul Thurrowgood, Hong Vo, Michael Wilson. Not pictured: Peter Anderson, Aymeric Denuelle. Image: Quadrotor aircraft, designed and developed in the biorobotics laboratory, for implementing and testing biologically inspired strategies for aircraft navigation.

Visual guidance in bees, birds and flying machines Birds and bees display remarkable navigational The bird laboratory is investigating the behaviour of comprising takeoff, cruise and return—without the capacities, despite their diminutive brains. The budgerigars as they move through varying environ- use of conventional navigational aids such as GPS. Srinivasan laboratory is using honeybees and ments. Examination of their flight through tapered This year has seen the commencement of research budgerigars as models to understand how animal tunnels is revealing two distinct flight modes: pertaining to three grants that were awarded to vision guides flight and enables navigation, and (i) A high-speed, energy-efficient ‘cruise’ mode, the laboratory: (i) An Australian Research Council to design biologically inspired systems for the when flying in open areas, and (ii) A low-speed (ARC) Discovery grant, in collaboration with QUT, guidance of aircraft. ‘manoeuvring’ mode, when negotiating cluttered to investigate the tracking of moving targets by environments. The advantage of such a strategy The bee laboratory is examining how aggressive aggressive bees, and design aircraft vision systems is that, for each speed, the distances to obstacles honeybees pursue and intercept moving targets. for automated target tracking; (ii) An ARC Linkage can be directly calibrated in terms of the optic flow High-speed video cinematography is revealing a grant, in collaboration with QUT and Boeing, to that they elicit. suite of behavioural strategies that comprise an investigate mid-air collision avoidance in birds, initial ‘orientation’ phase, a subsequent tracking The biorobotics laboratory has successfully tested and to develop aircraft vision systems for collision phase, and a final interception phase, which in com- a novel, biologically inspired vision system that avoidance; and (iii) An ARC Discovery Outstanding bination orchestrate a stealthy and rapid arrival guides an aircraft on a fully autonomous circuit— Researcher Award to study the perception of pain at the target. in invertebrates. Illustration of a budgerigar (yellow) closing its wings momentarily as it flies through a narrow gap (purple).

43 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Associate Professor Bruno van Swinderen

2014 Laboratory Members L–R/T–B: Bruno van Swinderen, Kathy Asmussen, Leonie Kirszenblat, Ben Kottler, Michael Troup, Melvyn Yap, Oressia Zalucki, Lachlan Ferguson, Matthew Van De Poll, Adekunle Bademosi, Aoife Larkin, Richard Faville. Not pictured: Kelly Munro, Esmi Zajaczkowski. Image: A fruit ﬂy’s attention is measured by how it responds to visual cues, in this case circularly moving stripes. Image by Leonie Kirszenblat.

Drosophila behaviour and cognition The van Swinderen laboratory uses the fruit fly In collaboration with the Srinivasan group at QBI, Pharmacological work in the laboratory is centred model Drosophila melanogaster to investigate the laboratory has created novel paradigms for on testing a hypothesis for general anaesthesia, perception and cognition. By combining power- tracking insect behaviour in virtual reality envi- and suggests that this common procedure actually ful molecular genetic tools with high-throughput ronments (Journal of Neuroscience Methods). involves two distinct steps: first a sleep process is behavioural assays and electrophysiology, they Closed-loop walking paradigms for honeybees and activated in the brain, and this is followed by a are able to study the underpinnings of complex fruit flies allow these insects to report their atten- synaptic defect (BioEssays). The Drosophila model phenomena such as selective attention, memory, tion-like states in different experimental scenarios. is ideally suited to testing this hypothesis, because general anaesthesia, and sleep in the more simple Combined with multichannel electrophysiology both sleep pathways and synaptic mechanisms can fly brain. To pay attention, learn, and sleep, a brain techniques developed in the laboratory, these par- be manipulated. In order to better measure sleep must be able to suppress parts of the outside world adigms provide insight into how small brains pay and general anaesthesia in flies, the laboratory effectively. Understanding how this suppression attention to the world. For example, research in the has invented a sophisticated platform called DART, mechanism works is a central question of the lab- laboratory found that attention-like signals in the Drosophila ARousal Tracking (Scientific Reports). oratory, with a focus on visual systems. honeybee optic lobes precede behavioural action selection (Proceedings of the National Academy This ring-like structure in the centre of the fly brain of Sciences of the USA). is thought to control spatial memory and attention. Image by Leonie Kirszenblat.

RESEARCH 44 Laboratory Head Professor Peter Visscher

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0-0.1 0.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Heritability in 12-16 year olds

2014 Laboratory Members L–R/T–B: Peter Visscher, Beben Benyamin, Marie-Jo Brion, Guo-Bo Chen, Anita Goldinger, Alexander Holloway, Luke Lloyd-Jones, Allan McRae, Gerhard Moser, Joseph Powell, Matthew Robinson, Philip Robinson, Sonia Shah, Konstantin Shakhbazov, Peter Smartt. Image: Stability of epigenetic DNA modiﬁcations in old people (y-axis) is correlated with heritability in young people (x-axis).

Genomes, genes and common diseases The Visscher laboratory specialises in quantita- In 2014, using human height as a model trait, the In collaboration with researchers from the QIMR tive and statistical genetics, population genetics, group demonstrated, in collaboration with a large Berghofer Medical Research Institute, Professor human genetics and bioinformatics, with the international research consortium, that individ- Visscher has established the Brisbane Systems ultimate aim of trying to understand the genetic ual differences in this complex trait are caused by Genetics Study, with the aim of understanding basis of differences in risk for disease and other the cumulative effect of thousands of genes, and genetic variation in the expression of genes and phenotypes between individuals. Applications of new analytical methods were developed to find its correlation with individual differences in com- the research include dissection of genetic varia- the responsible genes. The exact same analysis plex traits. In addition to the Brisbane study, a tion underlying cognition and cognitive change, methodology can be used to detect genes under- long-standing collaboration with Professor Ian and quantification and deciphering of the genetic lying cognitive ageing and dementia. The group Deary (University of Edinburgh, UK) has been architecture of psychiatric disorders. The group uses has also contributed analysis expertise to a large expanded through joint projects on the genom- theoretical derivations, simulation studies, devel- number of international research consortia that ics underlying cognitive ageing. By combining opment of new analytical methods and software have found genes affecting schizophrenia, obesity these studies, the group has shown that epige- tools, and the application of advanced statistical and auto-immune diseases. netic DNA changes—modifications that are not due analysis methods to genetic and phenotypic data. to sequence differences between people—can be Evidence for genetic heritability for epigenetic differences stable over the entire human life course. between people. All across the genomes there are DNA modifications that are shared between relatives because of their DNA sequence.

45 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Professor Stephen Williams ? ?88.μ4 <

2014 Laboratory Members L–R/T–B: Stephen Williams, Arne Brombas, Florence Cotel, Lee Fletcher. Not pictured: Simon de Croft. Image: 2-photon image of the dendritic tuft of a <8.42 neocortical output neuron. ?

Single neuron and neural circuit computation < 89:.4; The brain is fundamentally a computational device synaptic integration, and highlights how the brain dendritic integration. For example, their recent work in which nerve cells are arranged in intricate net- can operate in a fast and energy eﬃcient manner. has demonstrated that active dendritic integration works. Within these neuronal circuits computations The laboratory seeks to understand the rules and in the output neurons of the neocortex is strongly are performed that underlie all aspects of behaviour. mechanisms that form and control this rich neu- modulated by the cholinergic system, providing The Williams laboratory is investigating how nerve ronal integrative process and explore the relevance a plausible candidate mechanism for attentional @ cells and neural circuits implement computations. to the operation of neuronal networks in health processing. Furthermore, in the retina they are dis- They use advanced electrophysiological and optical and disease. secting the functional impact of the co-release techniques to investigate how neurons integrate of neurotransmitters from amacrine cells on the Over the last few years they have discovered that input signals termed synaptic potentials, received control of active dendritic integration in classes of 5'%=>13' active dendritic integration is recruited by natural throughout their dendritic tree, to produce an ganglion cells, in order to better understand visual stimuli, implementing circuit-based computations 0)4$ output signal. This work has shown that single processing. This work will lead to a better under- in the neuronal networks of the neocortex and A neurons can operate as complex computational standing of how networks of neurons function, retina to underlie key aspects of perception and devices, acting to produce ﬁnely tuned output sig- and ultimately how these processes are disturbed behaviour. Ongoing work is aimed at discovering nals through the engagement of active dendritic in disease. the circuit elements that drive and control active Active dendritic integration engaged by light stimuli in the retina.

RESEARCH 46 Laboratory Head Professor Naomi Wray

2014 Laboratory Members L–R/T–B: Naomi Wray, Earlene Ashton, Enda Byrne, Guo-Bo Chen, Jake Gratten, Anjali Henders, Hong Lee, Robert Maier, Divya Mehta, Natalie Mills, Wouter Peyrot, Matthew Robinson, Restuadi Swatanto, Anna Vinkhuyzen. QBI Bioinformatics Core: Zong-Hong Zhang, Qiongyi Zhao. Not pictured: Cara Nolan. Image: Genetic relationship between disorders estimated from genomic data, published in the review Gratten, Wray, Keller & Visscher, Nature Reviews Neuroscience, and summarises results from four studies published by the Wray laboratory.

Probing of the genomic complexity between & within psychiatric disorders Research in the Wray laboratory focusses on under- Women’s Mental Health), cannabis use (Molecular In 2014 the group worked with two genome-wide standing the genetic contribution to psychiatric Psychiatry) and major depression (Biological Psy- methylation data sets (the Lothian Birth Cohorts and neurological disorders. The group specialises chiatry). They played a role, both directly and over of 1921 and 1936, and the Sino-Australian MND in the development of new analytical methods and the past years, in the landmark paper published Cohort) and these new data are providing novel the application of advanced statistical methods in Nature that identified >100 loci associated with insights into environmental and genetic risks. A to the analysis of neuro-disorders. Group mem- schizophrenia. The group’s international standing National Health and Medical Research Council bers play leading roles in international consortia is recognised through invited reviews published (NHMRC) Early Career Fellowship has taken Dr Enda including the International Psychiatric Genomics in Nature Reviews Genetics, Nature Reviews Neu- Byrne to work at the sleep clinic at the University Consortium. In 2014 the group has expanded its roscience and Journal of Childhood Psychology of Pennsylvania. Grants awarded in 2014 include an research to include motor neuron disease (MND) & Psychiatry. Current research focusses on the NHMRC Principal Research Fellowship, an NHMRC and is a founding laboratory within the new Centre genetic relationship between schizophrenia and Career Development Fellowship to work on MND, for Neurogenetics and Statistical Genomics. rheumatoid arthritis (using new genomic data three NMHRC project grants, a National Alliance for Genetic effects on disease, from Witte, Visscher and Wray, to address an old epidemiological puzzle), the Research on Schizophrenia and Depression grant (Nature Reviews Genetics, 2014) in which methods from The breadth of research undertaken in the Wray genetic heterogeneity of schizophrenia and the from the US Brain and Behaviour Foundation and genetics and epidemiology are brought together under laboratory is illustrated by the publication portfolio gene–environment interactions in the context of an Arthritis Australia Fellowship. a unified framework. with studies of postnatal depression (Archives of psychiatric disorders.

47 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Laboratory Head Dr Jian Yang

2014 Laboratory Members T–B: Jian Yang, Andrew Bakshi, Zhihong Zhu. Image: Seven independent height-associated single nucleotide polymorphisms (SNPs) clustered in a 2.5Mb region.

Genetics and genomics of complex traits The Yang laboratory, within the Centre for Neuro- used in the research community for a range of In collaboration with the GIANT consortium, the genetics and Statistical Genomics (CNSG), works complex traits and diseases. group performed a large-scale genetic study for on the interplay of genetics, genomics, statistics human height using a data set of ~250,000 indi- The mixed linear model (MLM) approach has and computer science. Research in the Yang lab- viduals, with each individual having ~2.5 million become popular in genome-wide association oratory focusses on developing new statistical single nucleotide polymorphism (SNP) markers, studies (GWAS) since it controls for population methods and performing large-scale analyses of and identified 697 SNPs that are associated with stratification and relatedness in the GWAS cohort. high-throughput genetic and genomic data to height. These 697 SNPs clustered in 423 genomic The group used theoretical derivations, simulations understand the genetic architecture of complex loci are enriched for genes and pathways known to and analyses of real data to demonstrate why traits in humans, with specific interests in model be involved in growth and also implicated genes the MLM-based association analysis approach is traits such as height, and common diseases such and pathways not highlighted earlier. The paper under-powered, and proposed a solution that con- as obesity and schizophrenia. As demonstrated by was published in Nature Genetics, with Dr Yang trols for population structure without sacrificing the Mixed linear model-based association analysis excluding the number of citations, the methods and software as the joint first author. statistical power (Yang et al., Nature Genetics, 2014). the target single nucleotide polymorphism (SNP) controls tools developed by the group have been widely (red circles) for population structure and at the same time gains power, as compared to that including the target SNP, benchmarked by the traditional linear regression approach.

RESEARCH 48 Clem Jones Centre for Ageing Dementia Research

The Clem Jones Centre for Ageing Dementia Research program of recruitment to attract additional inter- even cure dementia in patients, using novel drugs (CJCADR) was opened in February 2013 as a major national researchers. and better methods to deliver them to the brain. research centre within QBI. The Centre, headed by Another outcome is the development of biomarkers “A number of outstanding researchers have been Professor Jürgen Götz, is focussed on research into to diagnose dementia earlier, more cheaply and appointed to the Centre: Dr Liviu Bodea from a the prevention and treatment of dementia. with higher sensitivity and specificity and to mon- leading neuroinflammation laboratory in Germany itor therapeutic interventions. Lifestyle strategies During 2013 both Queensland State Government and Dr Robert Hatch from a leading epilepsy labo- will also be formulated for maintaining a healthy and the Federal Government awarded a total of ratory in Melbourne,” Professor Götz said. brain”, Professor Götz said. $18 million over five years as a commitment to “We are very fortunate that in 2015 Dr Zhitao Hu accelerate the research towards a cure for dementia. The Honourable Ian Walker MP, then Minister for from Harvard University will join the Centre as a The research undertaken by CJCADR elucidates, at a Science, Information Technology, Innovation and Group Leader, as will Dr Patricio Opazo from the biochemical, molecular, behavioural, electrophysio- the Arts, toured the Centre on 19 November as Bonhoeffer laboratory at the Max Planck Institute logical, histological and systems level, how ageing part of the announcement of the $2.5 million of Neurobiology in Munich later in the year. These dementia causes neurodegeneration, the decline philanthropically funded international fellowship recruitments will and will have synergistic effects of memory and motor functions. to tackle stroke-induced dementia. on our research output.” Researchers from the following QBI laboratories “It is of vital importance to understand this particu- The Centre will further pursue novel strategies to undertake dementia-related research within lar type of dementia, as it is the cause for around reduce the burden of dementia. CJCADR: Bartlett, Coulson, Hilliard, Mangelsdorf, 40 per cent of dementias. This is another wonder- Meunier, Anggono and Götz. To expand on this “A major outcome is the discovery of therapeu- ful addition to our dementia initiative,” said QBI research, during 2014 the Centre commenced a Director Professor Perry Bartlett. tic interventions to delay the onset, prevent and 3D-Structured illumination microscopy (SIM) imaging of subtle structural elements in axons of mature hip- Above (L–R): Professor Warwick Anderson AM (National Health and Medical Research Council), CJCADR Director Professor Jürgen Götz, then Federal Health Minister The Hon Peter Dutton pocampal rat neuron, color coded for different z-axis MP, and QBI Director Professor Perry Bartlett. information. Image by Iris Wang.

49 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Centre for Neurogenetics and Statistical Genomics .

CENTRE FOR NEUROGENETICS !"#$ AND STATISTICAL GENOMICS 2014 members of the Centre for Neurogenetics and Statistical Genomics Statistical and Neurogenetics for Centre the of members 2014

In 2014 QBI launched the Centre for Neurogenet- which includes all the common diseases such as cross-fertilisation of ideas. CNSG also hosts the ics and Statistical Genomics (CNS Genomics or cancers, immune disorders, as well as some central QBI Bioinformatics core led by Dr Qiong-Yi Zhao. CNSG) to bring together a team of researchers nervous system disorders. Research in the core Completed in October, Level 7 of QBI was refur- with expertise in neurogenetics, neuropsychiat- theme focusses on development of new meth- bished to house the Centre. ric genetics, statistical genomics, bioinformatics odologies that are disseminated to the research In celebration of the new centre, the first Australian and computational biology. QBI Faculty Profes- community as publically available software for the Neurogenetics Conference was organised, bring- sors Peter Visscher and Naomi Wray co-direct the analysis of genomic data, which can comprise a ing close collaborator Professor Patrick Sullivan Centre, while Dr Jian Yang heads the core theme of million data points on hundreds of thousands of to Australia as the keynote speaker. In Novem- the Centre. CNSG also includes the laboratory of individuals. Around this core theme are themes ber Professors Visscher, Wray and Dr Yang spent Dr Marie Mangelsdorf, linking QBI’s analysis and that focus on applications to disorders or traits. three weeks touring research institutes in China to wet-laboratory based research on motor neuron Three of these themes are phenotype based and promote further collaborations there. CNSG expe- disease (MND). The Centre comprises about 30 staff, represent some major national and international rienced outstanding grant success in 2014 gaining all funded by competitive grant funding. collaborations. The fourth theme focusses on the two National Health and Medical Research Council genetics of genetic expression and DNA methyl- The core theme of the Centre is the genomics of (NHMRC) Fellowships, two NHMRC Career Devel- ation to further understand the mechanisms of complex traits. Complex traits are quantitative opment Fellowships, five NHMRC Project Grants, genomic control of phenotypes. CNSG members measures, diseases or disorders that are under- an Arthritis Australia Fellowship, a NARSAD grant work across multiple themes allowing important pinned by multiple genetic and non-genetic factors, and a UQ Early Career research grant.

RESEARCH 50 Science of Learning Research Centre

The Centre has several exciting new initiatives Finally, in partnership with Nature Publishing for 2015. A teacher intern, seconded from the Group, we will launch a new journal npj Science Queensland Department of Education, Training of Learning in 2015, of which Professor Sah will be and Employment, has been appointed to work Editor-in-Chief. This international journal will cover with researchers in the Centre. The Centre is cutting-edge research in all aspects of learning, and extremely grateful to the Queensland Depart- will provide a forum for discussion about learning. ment of Education, Training and Employment for The SLRC would like to acknowledge the support supporting this 12-month seconded position. To of the Australian Research Council and our Collab- support the Indigenous education program, Pro- orating and Partner Organisations: fessor Cindy Shannon (Deputy Vice-Chancellor, Indigenous at UQ), has joined the SLRC Advi- Collaborating Organisations: sory Board, and a senior Indigenous Research • The University of Melbourne Fellow, Tony Driese, has been appointed to the • Australian Council for Educational Research Centre and will take up an adjunct position at QBI in 2015. • Charles Darwin University • Curtin University A research translation group has also been established, headed by Professor John Hattie from the • Deakin University University of Melbourne and Associate Professor • Flinders University Annemaree Carroll from the UQ School of Edu- • Macquarie University cation. Among other activities, this group will • University of New England coordinate the development of course material for pre-service teacher training, Masters programs Partner Organisations: The year started with QBI’s Professor Pankaj Sah taking up the position of Director of the Science of and on-going teacher professional development. • University College London Learning Research Centre (SLRC) following the departure of Professor Ottmar Lipp from UQ to take up • University of London a position at Curtin University in Perth. Professor Lipp did a fantastic job establishing the Centre and In order to ensure SLRC research remains relevant he continues to be involved with it as a research theme leader. and its ﬁndings have an impact on learning, it will • Carnegie Mellon University continue to engage with schools and the teaching Under the leadership of Professor Sah the Centre undertook a review of its research, mapping out seven • North Carolina State University community. During the year Centre researchers programs of research running across three themes: Understanding Learning, Measuring Learning and • Questacon based at the UQ node delivered more than 20 pres- Promoting Learning. The programs are: entations, including seminars hosted at QBI and at • Benevolent Society schools and professional development workshops • Department for Education and Child THE INCORPORATING for teachers. Throughout the year more than 80 Development, South Australia LEARNING THE LEARNING Indigenous school students, ranging in age from PROCESS PROCESS INTO • Department of Education and Early STATE OF INDIGENOUS PRACTICE nine to 15 years old, visited the Centre at QBI as part Childhood Development, Victoria THE LEARNER EDUCATION of the UQ Solid Pathways Program. The Centre is • Department of Education, Training extremely grateful for all the support the schools and Employment, Queensland have given us throughout the year and looks for- ROLE OF ATTENTION LEARNING ward to our ongoing collaboration. FEEDBACK AND AND SELF- IN DIGITAL REINFORCEMENT REGULATION ENVIRONMENTS

STAGES OF INSTRUCTIONAL LEARNING PRACTICE Image top left: Early-career researchers from the SLRC shared knowledge of learning and the brain with school children as part of UQ’s Solid Pathways Program.

51 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Joint Research Laboratories

2014 was a productive year within QBI’s joint In August the State of Queensland and the Chi- Vice Minister for Science and Technology, Profes- research laboratories in China, with numerous nese Ministry of Science and Technology (MOST) sor CAO Jianlin, with Minister Walker commenting visits occurring to progress current research pro- extended their partnership through the re-signing that he was pleased to see that Australia’s valuable jects and initiate new ones, and several papers of a Memorandum of Understanding (MOU). This relationship with China was continuing to grow. being published. A highlight was the special issue presented an ideal opportunity for the Institute The Joint Sino-Australian Neurogenetics Laboratory, of Science China Life Sciences, “From Brain Func- to strengthen their relationship with China, with with colleagues at The University of Queensland tion to Therapy” published in April. The journal ran the signing of a Memorandum of Understanding Diamantina Institute and the Second Military several reviews, research papers and commentaries, for a new Joint Australia-China Research Centre Medical University in Shanghai, is exploring how which showcased the collaborative work that is focussed on understanding the circuitry and genes inﬂuence brain development and function, being undertaken within the Joint Laboratory of genetics in ageing dementia. The team, which and focusses on discovering the genes that cause Neuroscience and Cognition, with colleagues at the includes researchers from QBI, IBP and CASIA, or make individuals susceptible to certain neu- Chinese Academy of Sciences’ Institute of Biophys- will focus on understanding the mechanisms rological and mental illnesses. The collaboration ics (IBP) and the Joint Sino-Australian Laboratory of that regulate cognitive decline and dementia in has been extended to include researchers from Brainnetome with the CAS Institute of Automation the ageing population and provide insights for QBI’s preeminent Centre for Neurogenetics and (CASIA) in Beijing. diagnosis and therapy. Given the ever-increasing Statistical Genomics (CNSG). The joint program ageing population of both countries, this is an has already exome sequenced a large number of important endeavour. patients with neurodegenerative disease, with The signing was witnessed by the Queensland new samples continually being sourced through Minister for Science, Information Technology, Inno- the CNSG. This exciting and promising work will vation and the Arts, Ian Walker, and the Chinese continue in 2015.

Above: Professor Perry Bartlett and Professor Li Liu (foreground), witnessed by then Queensland Minister for Science, Information Technology, Innovation and the Arts, The Hon Ian Walker MP and the Vice Minister of the Chinese Ministry of Science and Technology, Cao Jianlin (background).

RESEARCH 52

Queensland Brain Institute Annual Report 2014

Students

Students play an integral role in the cutting-edge research undertaken at QBI.

Students travel from as far aﬁeld as China, Latin America and Europe to study, bringing fresh, innovative and international approaches to neuroscience research at the Institute.

Leonie Kirszenblat, van Swinderen Laboratory.

STUDENTS 54 Postgraduate Students

Postgraduate Award (APA), and the UQ Advantage showcased students’ work and provided a forum for Top-Up Scholarship. Xiaoqing Zhou (China) was four graduating students to give plenary lectures awarded the China Scholarship Council (CSC) Schol- on their research findings. Another seven QBI stu- arship and the UQI Tuition Fee Scholarship. Lisa dents were selected to present short talks on their Wittenhagen (Germany) was selected to receive research during the event. Students were judged the Australian Research Council (ARC) Australian on their presentations with prizes being awarded to Laureate Fellowship living allowance scholarship, Sean Coakley (best plenary talk), Karly Turner (best and was awarded the UQI Tuition Fee Scholarship. short talk), and Laura Fenlon (runner-up award, Six domestic PhD students who commenced their short talks). QBI congratulates these students on studies in 2014 each secured the APA living allow- their accomplishment. Professor Miguel Nicolelis, ance scholarship. Also, one domestic student was a world-renowned neuroscience researcher from awarded a living allowance scholarship from Boeing Duke University, USA was invited to present the Defence Australia Ltd. PhD student Toni Turnbull keynote address at the Symposium and his superb was the recipient of a Top-Up Scholarship awarded talk was enthusiastically received by the audience. by the Alzheimer’s Australia Dementia Research The Institute sincerely thanks its Student Associa- Foundation. tion for organisation of the inaugural event, which was an enormous success. A number of QBI students were also successful in receiving competitive awards and prizes during the QBI welcomed two UQ MBBS students, Casey year. Some of the most successful recipients were: Linton and Timothy Edwards, who were accepted into the School of Medicine’s intercalated MBBS- • Dr Ramesh Narayanan and Dr Roger Marek MPhil program. Casey and Tim are based at the received the 2013 Dean’s Award for Research Institute to undertake their research higher degree 2014 was a successful year for QBI in attracting Following the completion of their research higher Higher Degree Excellence (awarded in 2014). research higher degree students, with student degree, these graduates obtained employment in studies under the supervision of QBI researchers. numbers increasing to 102 enrolled candidates. postdoctoral positions or in other research admin- • Stephanie Biergans, Ming Soh and Morgane As Tim and Casey have made excellent strides in Of these enrolments, 42 were from international istration roles within Australia or internationally. Nouvian were each awarded a UQ Graduate their MPhil studies, they have progressed up to the students across 20 countries. The total enrolment School International Travel Award (GSITA) to PhD program to continue their research, working Competitive scholarships were awarded to QBI figure also includes 20 new domestic and interna- spend some time working on their research towards this award. Both students received the students throughout 2014. It was also a historic tional students who were all warmly welcomed at projects in laboratories in Germany, Denmark UQ Research Scholarship (UQRS) to support them time for QBI as the Institute offered its very first the Institute as they commenced their candidature and France, respectively. during their research higher degree. PhD Scholarship to international candidate Annal- • Karly Turner won the 2014 Chapter Travel Award during the year. QBI was also pleased to receive undergraduate and isa Paolino (Italy). She was also awarded the UQ to attend the Society for Neuroscience meeting postgraduate coursework students through the QBI was delighted to see the conferral of 14 PhDs International (UQI) Tuition Fee Scholarship. In held in Washington in November. and one MPhil* upon the following students, future years, QBI aims to utilise our scholar- annual UQ Winter and Summer Research Programs. and we congratulate each scholar on their signif- ships to attract the best students to undertake • Xiang Li was selected as the winner of the QBI The Winter Research Program involved a total of icant academic achievement: Anna Bode (Lynch); their research higher degrees in neuroscience. Student Publication Prize for the best published four students who participated in various labora- Wen-Sung Chung (Marshall); Sean Coakley (Hill- Anne Maallo (Philippines) was awarded the top paper in 2014 sponsored by Sigma-Aldrich, and tory-based projects across four different laboratory iard); Christine Dixon (Lynch); Helen Gooch (Sah); international scholarship offered at UQ, the Inter- Laura Fenlon won the QBI Student Publication groups over a six-week period. For the Summer Veronika Halasz (Cunnington); Callista Harper national Postgraduate Research Scholarship (IPRS), Prize for the best published paper in 2014 spon- Research Program 2014/2015, QBI accepted 19 (Meunier); Shao-Chang Huang (Reinhard); Thai Vinh in conjunction with the UQ Centennial Living sored by QBI. domestic and international students to undertake Nguyen (Cunnington); David Painter (Mattingley); Allowance Scholarship. She also received the QBI The QBI Student Association organised a number a range of projects across 13 different laboratory Simandeep Poonian (Cunnington); Vikram Ratnu Top-Up Scholarship. Loc Duyen Pham (USA) was of events and seminars for students during the groups within QBI over a 10-week period. (Bredy); Amanda Robinson (Reinhard); Aanchal awarded the IPRS in conjunction with the top year, including the inaugural QBI Graduate Student Sharma* (Coulson); and Vanesa Tomatis (Meunier). Australian Government scholarship of Australian Symposium held in December. The Symposium Above: Casey Linton is studying a Bachelor of Medicine & Bachelor of Surgery, as well as undertaking a PhD at QBI. 55 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Student Proﬁles

Students chart course to success Students at QBI are provided with opportunities to pursue their research interests, while working closely with dedicated neuroscientists. This research experience provides the students with a solid foundation for career success.

Dr Sean Coakley In 2009 I joined the laboratory of Associate Professor Massimo Hilliard to begin my PhD at QBI. The goal of my PhD was to discover novel genes involved in axonal regeneration and degeneration. The Hilliard laboratory studies these processes in the genetic model organism Caenorhabditis elegans (C. elegans), a free-living non-parasitic nematode. The transparency, small size and powerful genetic tools of C. elegans make it an attractive system in which to study the fundamental mechanisms of neurobiology. I was particularly excited about the prospect of being able to see nerves regenerating in living animals, in real time, and manipulating these events with genetic tools. This is something that still takes my breath away every time I see it. As part of my PhD I developed a method of causing damage to the nematode’s neurons using a light stimulated protein called KillerRed, which generates reactive oxygen species (ROS) upon irradiation. We hope this tool will allow a greater understanding of how neurons respond to damage caused by ROS, which are also generated in several neurodegenerative diseases. In addition, a second major focus of my research is how the axon of a neuron, which is the component responsible for sending electrical signals, can be repaired following damage. To study this regenerative process I developed an experimental paradigm utilising mutant animals that lack a component critical for the axon’s stability. In these animals the axons are fragile and spon- taneously break, allowing the study axonal repair to be achieved without the need to surgically damage the animals. A major advantage of this approach is that it facilitates large-scale genetic screens for molecules involved in axonal regeneration. Using this model, I made a major contribution to the discovery of a novel molecular mechanism that enables severed axons in C. elegans to rapidly fuse and repair the original connection. Since the completion of my PhD in 2014 I have continued my exciting research in the Hilliard laboratory. I hope my research will lead to a better understanding of nerve repair caused by injury, which remains largely untreatable.

STUDENTS 56 Student Proﬁles Master of Neuroscience

Dr Vanesa Tomatis After performing my research training in key molecules that I found to participate Argentina, I joined Professor Frederic Meu- in this process is myosin VI. During my nier’s laboratory in 2010 to undertake my PhD, I showed that myosin VI regulates doctoral studies. I was sure that studying the availability of secretory vesicles that at QBI was going to be a challenge, but release their content to the extracellular also a very exciting time. QBI offers great space. This is a key event behind neuronal tools that students need to overcome communication. My findings have not only difficult times and promote success, excel- contributed to the better understanding lent facilities equipped with world-class of neurotransmission, but also and more technologies, very good management, importantly have opened new avenues for as well as the possibility to discuss sci- research that could help us to develop new ence with well-known researchers (QBI molecular therapies for diseases character- and UQ-based, and invited visitors). This ised by altered levels of neurotransmitter combination makes studying at QBI an or hormone release. The results of my enjoyable experience. research during my PhD were published in the Journal of Cell Biology in 2013 and I My research focussed on deepening the was joint winner of the QBI Student Pub- understanding of neurotransmitter release lication Prize of the Year 2013 sponsored and their regulatory mechanisms. By gain- by Sigma-Aldrich. ing experience in different techniques such as mass spectrometry, biochemistry and After obtaining my PhD in 2014, I started microscopy, I obtained evidence of how as a Postdoctoral Researcher in Profes- secretory vesicles are tethered to the sor Meunier’s laboratory working on plasma membrane of cells before their the mechanism underpinning myosin VI fusion, allowing sustained neurotransmit- function during neuroexocytosis. ter release upon stimulation. One of the

57 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Master of Neuroscience Dr Wen-Sung Chung

The Master of Neuroscience program was intro- Compulsory core lecture-based courses duced in 2010 as an initiative of QBI Director in the Master of Neuroscience program: Professor Perry Bartlett and former UQ Senior • Systems Neuroscience: Sensory and Motor Deputy Vice-Chancellor Professor Deborah Terry, (NEUR7004), which uses a systems approach to as a pathway for students who wish to shift their explore the brain with respect to circuits that career focus to neuroscience and pursue independ- integrate and process information. ent research and teaching careers. • Cognitive and Behavioural Neuroscience The program is coordinated by QBI and the Faculty (NEUR7005), which focusses on the elucidation of Social and Behavioural Sciences (now Faculty of of the neural basis of cognitive and behavioural Health and Behavioural Sciences) but also spans phenomena. other centres for neuroscience research at UQ. To • Molecular and Cellular Neuroscience (NEUR7006), ensure quality of student experience and teach- which is concerned with cellular and molecular ing, a quota of 12 students per semester has been biology of the neuron. imposed upon the course. Together with the three Master of Neuroscience Providing research training and core professional laboratory rotations, which offer 300 hours of A passion for finding unseen marine creatures and my curiosity about their sensory skills, the program is a pathway to specialist supervised practical experience, these courses world drove me to do research. I commenced my PhD in the laboratory of Professor streams including molecular and cellular neu- provide a cohesive introduction to the theoretical Justin Marshall in 2009, investigating visual ecology of cephalopods. As a student roscience, neural imaging and computational and practical aspects of neuroscience. Rotations can within the Deep-Australia project, I have been able to sample surface waters around neuroscience, developmental neurobiology, cog- be undertaken in a wide number of participating Moreton Bay (an area rich with cephalopod species), as well as investigate deep-sea nitive and behavioural neuroscience, visual and schools, including QBI, UQ’s Schools of Psychology, habitats down to below 2,000 metres, both with cameras and nets. Aside from the sensory neuroscience, and epigenetics. The Master Pharmacy, Medicine, Biomedical Sciences, Microbial of Neuroscience runs for three semesters (24 units), and Molecular Biosciences, Information Technology excitement of working at sea, investigating the squid visual system through labora- and Electrical Engineering, the Perinatal Research tory work has uncovered new adaptation mechanisms of this soft-bodied creature although students with Honours or equivalent can complete the program in two semesters (16 units). Centre, Centre for Clinical Research, the Institute that were unexpected prior to my PhD. Firstly, a new range-finding mechanism in for Molecular Bioscience, the Centre for Advanced the coastal squid proposed that the retinal deformation and the resulting image In 2014, a total of four students graduated with Imaging (CAI) and the QIMR Berghofer Medical blur, combined with a unique head-bobbing behaviour, are vital for searching for the Master of Neuroscience degree: Adekunle Research Institute. food and avoiding threats in the featureless open ocean. Also, my project uncovered Bademosi, Samuel Fynes-Clinton, Muthmainah, and Ozlem Yetim. A new initiative has been taken to convert the that the simple squid eye has developed complex visual adaptations associated current coursework Master of Neuroscience pro- with a variety of light regimes and different modes of life. Furthermore, I operated In 2014 the program also welcomed three interna- gram to a research Master of Philosophy (MPhil) a UQ-designed underwater camera platform, Medusa, which filmed the first giant tional and five domestic students: Aprianto Dirga, in Neuroscience. The UQ Graduate School and QBI squid behaviour in their natural habitat (770 metre depth) in 2012. The feeding Arezoo Fallah, Sheridan Harvey, Meera Jacobs, are currently developing the MPhil in Neuroscience behaviour of the giant squid, particularly striking the light lure, demonstrated that Apurva Kumar, Kelly Munro, Joseph Peard, and program for commencement in 2016. Although they are aggressive and active visual predators. Given their fast movement ability, Matthew Trewella. the Master of Neuroscience program has been successful, given recent changes in the research enormous eyes and corresponding visual capability, these new observations help Students completing their Master of Neuroscience higher degree environment, and the need to align paint a picture of a top predator. program say that the experience has encouraged program offerings with university systems world them to pursue further study opportunities, such wide, it was decided to modify the coursework Following the completion of my PhD thesis, I am continuing my research to describe as PhDs. and explain the new retinal design elements, undertake more behavioural obser- program to a research-based study program. The vations on both shallow and deep-living species large and small, as a Postdoctoral Master of Neuroscience has been withdrawn as from 2015, and Semester 2, 2014 saw the final intake

Above left: Launch of the manned submersible, Triton, on a mission to find giant squid. squid. giant find to mission a on Triton, submersible, manned the of Launch left: Above mid- the in Medusa, platform, camera the to next standing Chung Wen-Sung Dr right: Above water drifter configuration for unobtrusive observation of deepwater fauna down to 2,000m. Researcher in Professor Marshall’s laboratory. of students into the program. The coursework Mas- ters program ran for five years and 31 students have graduated from the program.

STUDENTS 58

Queensland Brain Institute Annual Report 2014

Community

QBI’s goal is to make a positive impact on the Australian community by helping to reduce the huge social and ﬁnancial cost of neurological and mental illness.

In 2014, QBI hosted a series of high profile events and conducted a range of community outreach programs. In addition to educating Australians about the latest research findings, staff also continued their efforts to encourage the next generation to consider careers in neuroscience.

QBI researchers giving donors a tour of the Clem Jones Centre for Ageing Dementia Research.

COMMUNITY 60 Lectures

Peter Goodenough Lecture Merson Lecture Progress in schizophrenia: three stories Developing better treatments for Alzheimer’s disease: the long and short of it The 2014 Peter Goodenough Lecture was delivered Professor Lennart Mucke of the Gladstone Institute on 10 September by Distinguished Professor Patrick of Neurological Disease and University of Califor- Sullivan of the University of North Carolina, USA. nia, San Francisco, USA, presented an informative 2014 Merson Lecture on understanding Alzheimer’s Professor Sullivan investigates the molecular genet- disease. ics and pharmacogenetics of schizophrenia, major depressive disorder, and anorexia nervosa. QBI was fortunate to listen to Professor Mucke, a Distinguished Professor of Neuroscience, give Based on his decades of experience, he presented insight into processes that result in memory loss a lecture on three stories that are central to the and other deficits. current efforts to identify the genetic basis of schizophrenia. Professor Mucke discussed some of the obstacles on the path of translating scientific insights into Firstly, he outlined the unprecedented international more effective treatments for Alzheimer’s disease, collaborations that made advances announced in and the potential strategies that could be employed 2014 possible—including those at QBI. to overcome them. Secondly, Professor Sullivan spoke about the find- He expressed his opinion that more effective links ings that have led to a much wider appreciation of are needed between basic scientists and clinical the complexity of schizophrenia by discovering the investigators, and between academia and the large number of genes involved in the disorder. pharmaceutical industry. Thirdly, he emphasised how researchers can begin He stressed the urgent need to expedite the dis- to go beyond finding genes to using genes, with covery and validation of potential drug targets and the objective to improve diagnosis, treatment, and the production of new therapeutics, and the roles prevention. these players have. The Peter Goodenough annual lecture is named in The Merson Lecture is named in honour of Dr David honour of the late Mr Peter Goodenough (1936– Merson, member of the QBI Advisory Board, whose 2004), a QBI benefactor, whose personal battle with philanthropic sponsorship of this lecture is indica- motor neuron disease led to a bequest to fund tive of a strong community interest in neuroscience. fundamental scientific research. Mr Goodenough’s gift is a showcase example of how members of the community can make a powerful and lasting contribution to the future health of all Australians.

Right: Professor Patrick Sullivan delivering the 2014 Peter Goodenough Lecture. Far right (L-R): Professor Perry Bartlett, Professor Lennart Mucke and Dr David Merson.

61 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014 Events

Hand Heart Pocket ASSC18 Super-Resolution Symposium Ross Maclean Fellowship Gala Evening Race Day QBI partnered with the Alzheimer’s Australia (Qld) QBI researchers played an integral role in bringing As part of UQ Microscopy Week 2014, QBI hosted More than 200 guests helped to raise $25,000 for to create a lavish event to raise funds and awareness the Association for the Scientific Study of Con- the Super-Resolution Symposium on 4 April. motor neuron disease (MND) research by attend- for Alzheimer’s disease research and care. sciousness (ASSC) conference to Australia for the ing the Ross Maclean Fellowship Caloundra Cup With speakers from across UQ, the event show- first time, with ASSC18 being held at UQ during on 28 June. Generously supported by Hand Heart Pocket, cased some of the work being conducted at the 16–19 July. The Charity of Freemasons Queensland, the gala University, including seven QBI staff who pre- Held at Corbould Park Racecourse at the Sunshine evening was attended by more than 160 enthusi- Seeking to answer what consciousness is, and how sented their work: Luke Hammond, Dr Ilan Gobius, Coast Turf Club, the day was one of the jewels astic supporters who were dazzled by a night of it can be measured, the conference covered topics Dr Callista Harper, Dr Miriam Matamales, Dr Brent of the 2014 Queensland Winter Racing Carnival. opera and classical music. as broad as studying pain, sleep, and attention. Neumann, Dr Andreas Papadopulos, and Professor MND, a fatal disease with no cure, is being actively Frederic Meunier. Brisbane’s iconic Customs House proved to be the The conference was organised by QBI group leader fought at QBI, and the vital funds directly helped perfect backdrop for the event held on 5 Septem- Associate Professor Bruno van Swinderen. Super-resolution microscopes enable single mole- to support the work. ber, with performances held indoors and a cocktail cule imaging, which allow the study of individual The conference had a number of high profile The event was made possible thanks to a number party overlooking the Brisbane River. receptors on synaptic terminals. speakers, including Professor Emery Brown from of generous supporters including Ross Maclean The night’s operatic repertoire included Madama the Massachusetts Institute of Technology, who The program featured sessions of advanced imag- Racing, Shaun Flanigan, Jeff Maclean, the Index Butterfly’s dramatic and captivating ‘Un Bel Di’, addressed the audience on the topic of what ing techniques, live imaging, tissue imaging and Group, Village Roadshow Themeparks, Naomi sung by Zara Barrett, winner of the Covent Garden happens to us when we ‘go under’ and are presentations on facilities at the University. Kito Baliey, McKinney’s Jewellers, Rumba Resort, (1995) and Metropolitan Opera Scholarships. (1993, anaesthetised. Euromarque Maserati Brisbane and Willims Motor QBI’s Advanced Microscopy Facility is home to 2000, 2001). Group, The Training Spot Albion and Ricky Gibson, Distinguished Professor Jesse Prinz from the City two of Australia’s most powerful super-resolution the Australian Wallabies and Treasury Wine Estate. Singapore Lyric Opera soprano Cherylene Liew also University of New York, USA, also spoke on whether microscopes. captivated the audience, as well as basso profundo consciousness and attention are dissociable. The Ross Maclean Fellowship was established in The equipment housed in QBI has capabilities to David Hibbard, who won the 1990 German Oper- 2004 by the late Ross Maclean to raise funds to The conference closed with a free public lecture at create 3D reconstructions of brain sections and atic Award. fight this most devastating disease. the State Library of Queensland by Professor Stanis- rapidly image neuronal outgrowth and intracellular String quartet Cerebrum, consisting of the Conserv- las Dehaene, an international leader in the field of trafficking. Since that time, his family have been instrumen- atorium and UQ’s finest string players, performed cognitive neuroscience at the Collège de France. tal in carrying on the legacy established by Mr the well-known ‘Trout Quintet’. Maclean, and have championed the cause of promoting and raising funds for MND research at QBI. Funds raised on the night supported research conducted at the Clem Jones Centre for Ageing Dementia Research (CJCADR).

Right: Guests at the Hand Heart Pocket Gala Evening at Brisbane’s Customs House.

63 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014 Community Outreach Australian Brain Bee Challenge

Breakfast Series New Fellowships

QBI’s community outreach program engages What causes brain malformation? Stafford Fox Medical Research Fellowship John Trivett Foundation Senior people with an interest in discovering more Professor Linda Richards and in stroke-induced dementia Research Fellowship in brain cancer about neurological disorders and how the brain Associate Professor Helen Cooper The Stafford Fox Medical Research Foundation’s The John Trivett Foundation, newly merged with functions. The program’s success is proof of the generous support will enable this fellowship for Cure Brain Cancer Foundation, initiated philan- public’s thirst to learn more about the latest The power of attention: how attention research into vascular dementia. Caused primarily thropic support to consolidate research in brain research. filters sensory information which by strokes, vascular dementia accounts for up to cancer at UQ. The John Trivett Fellowship will be a underpins perception, choice and action 40 per cent of dementias, and consequently is a joint appointment between QBI and the Institute The Institute conducts regular tours through its Supported by Mind Gardner vital area of research as we seek to address the for Molecular Bioscience at UQ. world-class facilities, and the researchers frequently Professor Jason Mattingley dementia epidemic. present lectures, talks and discussions that form the core of the community outreach program. This Women in business & science: why Scott Sullivan Research Fellowship interaction has continually proven beneficial for in motor neuron disease both the public and scientists. are there so few women CEOs and Professors in Australia? This fellowship, supported by the MND and Me In 2014 QBI held a number of events designed Dr Terrance Fitzsimmons, Lecturer and Postdoc- Foundation and the Royal Brisbane and Women’s to celebrate the support that both individuals toral Research Fellow, UQ Business School Hospital Foundation, will accelerate research output and community groups have provided for QBI’s Professor Linda Richards and co-ordinate preclinical trials for promising new research. therapies in motor neuron disease research. The Motor neuron disease (MND): Fellow will act as a bridge between the clinic at the what is the current state of play? Royal Brisbane and Women’s Hospital and QBI. Professor Naomi Wray, Centre for Neurogenec- tics and Statistical Genomics (CNSG) at QBI Dr Rob Henderson, Director of Neurology at the Royal Brisbane and Women’s Hospital (RBWH)

65 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Australian Brain Bee Challenge

The Australian Brain Bee Challenge (ABBC) is a Round two is an ABBC state/territory final hosted by Round three is the ABBC National Final, in which The ABBC has had more than 30,000 students public outreach program for high school students universities or research institutes across Australia. each state/territory Champion competes to become participate in round one over the nine years since that aims to provide an opportunity to engage The round two Queensland ABBC final took place the ABBC Champion. The 2014 ABBC National Final it was established in Australia by Professor Linda young Australians, as well as their families, teachers at QBI on 22 July and was attended by 200 Year will be held in April 2015 at the University of West- Richards and QBI. ABBC student alumni have gone and the wider community, to learn about neuro- 10 students and teachers, some of whom travelled ern Australia. on to undertake undergraduate degrees in a wide science and neuroscience research. The ABBC is from as far as Cairns, Weipa and Ingham to par- variety of disciplines. Some have now completed The ABBC is affiliated with the International Brain Australia’s only neuroscience competition for high ticipate. During the day the students competed research higher degrees in neuroscience and have Bee (IBB) and each year the Australian Champion school students and provides opportunities for all in the competition, toured the facilities at QBI, worked throughout their studies at QBI. Many state has the opportunity to compete in the IBB. The 2013 Australian students, including those from regional observed experiments and talked to QBI scien- and national winners have also completed work Queensland and Australian Champion Eva Wang areas, to participate and to consider a career in tists about their research, discoveries and how they experience in laboratories at QBI. As of January attended the IBB in Washington DC in August 2014 science, and, in particular, neuroscience. became involved in scientific research as a career. 2015, the national headquarters will move from and placed second against competitors from 22 The students and teachers also had the opportunity QBI to the University of Western Sydney. QBI will The ABBC has three rounds, with round one taking countries. It was an outstanding effort from Eva, to hear from Professor Melvyn Goodale, Canada continue to host round two, the Queensland ABBC place in March during the annual Brain Awareness who has a keen interest in neuroscience and com- Research Chair in Visual Neuroscience and Director Final and to engage high school students in under- Week. Round one of the ABBC is an online quiz pleted work experience placements at QBI in both of The Brain and Mind Institute, Western University, standing the importance of neuroscience research in which students demonstrate their knowledge 2013 and 2014. Ontario, Canada. After a close individual compe- and learning about neuroscience. and understanding of brain structure, function, tition, Somerville House student Sophie Watson anatomy, and their understanding of neurological was the winning student on the day, becoming disease and disorders. 6,000 students completed the 2014 Queensland ABBC Champion. round one in 2014. Above: Students competing in the Queensland Final of the ABBC, with winner Sophie Watson far left of image.

COMMUNITY 66

Queensland Brain Institute Annual Report 2014

Recognition

QBI houses more than 300 researchers, working across the span of neuroscience to understand the body’s most remarkable organ.

Our researchers are highly regarded, and represent the Institute in a number of pivotal scientiﬁc organisations and serve on prestigious editorial boards. The quality of our publications, grants and awards stands QBI in the top echelons of scientiﬁc research.

Lavinia Codd (Bartlett laboratory) discusses her research with the then Queensland Minister for Science, Information Technology, Innovation and the Arts, The Hon Ian Walker MP.

RECOGNITION 68 Fellowships and Awards Commercial Development Overview

National Health and Medical Research Council Australian Research Council Awards Research Fellowships Australian Laureate Fellowship Australasian Neuroscience Society Australasian Neuroscience Society Commencing in 2014 Professor Joe Lynch was Professor Justin Marshall received a prestigious Distinguished Achievement Award Paxinos-Watson Prize promoted to Principal Research Fellow. During Australian Laureate Fellowship to investigate the In recognition of “an outstanding contribution by The 2014 Paxinos-Watson Prize for the most the course of his fellowship Professor Lynch will specialised visual systems of marine creatures from an individual to neuroscience in Australia”, Pro- significant paper published by a member of the study inhibitory neurotransmission in the central the Great Barrier Reef. In particular, he will focus on fessor Perry Bartlett received the Distinguished Australasian Neuroscience Society in the 2012 cal- nervous system, which is mediated by GABA type A how they receive and interpret colour and polarisa- Achievement Award from the Australasian Neu- endar year was awarded to a publication from the (GABAA) and glycine receptors. GABAA receptors tion information, much of which is invisible to the roscience Society, making him only the seventh laboratory of Professor Geoffrey Goodhill. Correct have long been important clinical targets for human eye. The resultant data will then be used to recipient of award since it was inaugurated in 1993. wiring of the nervous system relies on the molec- therapies directed at muscle relaxation, epilepsy, inform the design of the next generation of polar- Professor Bartlett was honoured for his individual ular guidance of the axons of nerve cells to their anxiolysis, sedation and anaesthesia, whereas isation cameras, which may improve our ability research excellence, his advocacy for Australian appropriate targets. The Goodhill study (Forbes, glycine receptors are emerging as clinical targets to detect dysfunction in neurons and other cells. neuroscience, including as a past President of Thompson, Yaun & Goodhill, Neuron 174: 490-503, for chronic pain and spasticity. Professor Lynch the society, and his contribution to the growth 2012), which appeared in one of the world’s leading will capitalise on his expertise in the molecular Discovery Outstanding Researcher Award of national research capacity through the estab- neuroscience journals, constructed a mathematical pharmacology of these receptors to develop new As part of a major ARC Discovery project grant to lishment of QBI. model to explain the way in which calcium and treatments for neurological diseases and to under- commence in 2014, Professor Mandyam Srinivasan cyclic AMP, two key regulators of whether axons stand the molecular mechanisms of receptor and received a professorial-level Discovery Outstanding Queensland Government Science Champion are attracted or repelled in particular molecular synaptic dysfunction in neurological disease. Researcher Award, making him one of only 15 such The Queensland Government has acknowledged gradients, interact to produce correct guidance recipients Australia-wide. During the course of his the contribution of Professor Srinivasan to the responses in the nervous system. They then used Nerve terminals and neurosecretory cells contain three-year study Professor Srinivasan will explore study of insect and bird navigation and unmanned this model to generate predictions that they were synaptic vesicles and secretory vesicles, respec- whether the relatively simple nervous system of aerial vehicle design by naming him as one of two able to confirm experimentally. This work has tively, which are filled with the neurotransmitters the honeybee is capable of higher cognitive func- inaugural Science Champions. The Champions important implications for our understanding of responsible for neuronal and hormonal communi- tions that are commonly ascribed to vertebrates, program forms part of the Government’s Science how correct neural circuits form during develop- cation. A range of diseases of the nervous system including a rudimentary level of consciousness, and Innovation Action Plan, and is designed to ment and regeneration. are caused by defects in vesicular trafficking, basic emotions, and the sensation of pain. recognise excellence in research and innovation. including neurodegenerative conditions such as Royal Institute of Navigation Harold Alzheimer’s disease as well as epilepsy. As a newly Spencer-Jones Gold Medal promoted Level B Senior Research Fellow, Profes- The UK-based Royal Institute of Navigation awarded sor Frederic Meunier will explore the molecular Professor Srinivasan their highest honour, the mechanisms underpinning vesicular trafficking Sylvia and Charles Viertel Foundation Harold Spencer-Jones Gold Medal, and have elected pathways using a variety of complementary him a Fellow of the Institute, in recognition of his techniques, including super-resolution micros- Senior Medical Research Fellowship outstanding contributions to our understanding of copy. The ultimate goal of this research is to use In 2014 Dr Jian Yang commenced his Sylvia and Charles Viertel Charitable Foundation animal navigation techniques. Professor Srinivasan this knowledge to drive the development of new studies insects and birds to elucidate how animals therapeutic strategies. Senior Medical Research Fellowship, which will develop methods and large-scale genomic analyses to study the genetic basis of neuropsychiatric disorders. One of with small brains navigate complex environments. He then applies this information to improve the only two recipients of this prestigious national fellowship, Dr Yang will apply his collision avoidance strategies of unmanned aerial background in genetics and statistics together with his outstanding skills in com- vehicles. putational biology to answer fundamental questions about the genetics of common disease and to develop software tools capable of analysing millions of DNA markers. The goal of this ambitious five year program is to gain a better understanding of why some people are more susceptible to disease than others.

69 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Commercial Development Overview

QBI commercialisation activities in 2014 focussed excess neuroinflammation after stroke and the on the business development and maintenance potential use of GlyR alpha3 modulators for the of existing intellectual property, and the business treatment of chronic pain. Commercial partners development and protection of new intellec- are being explored for both projects. tual property (IP) through its relationship with The ARC linkage agreement with QBI researchers UniQuest. UniQuest is one of Australia’s leading continues with Boeing to develop collision avoid- commercialisation companies, specialising in ance systems. In addition, QBI researchers continue global technology transfer and facilitating access to participate in the Cooperative Research Centre for all business sectors to world-class university (CRC) for Living with Autism Spectrum Disorders expertise and IP. that commenced in 2013, and the Science of A new provisional patent was filed for the use of Learning Research Centre funded by the Australian ultrasound methodology to treat neurodegenera- Research Council. tive diseases. This IP originated from CJCADR and Agreements were negotiated in the last period with current activities are focussed on the potential Euclideon, whereby QBI researchers will collaborate market and development opportunities. with Euclideon to build new 3D visualisation tools New IP related to a patented therapeutic protein to support brain research. for the treatment of spinal cord injury and MND In 2014, QBI attended and exhibited at BIO2014 has been developed, which will provide additional in San Diego. BIO is one of the largest interna- protection for the project. Plans to take the protein tional conferences for biotechnology, and QBI and into clinical trials are ongoing with support from UniQuest held a number of discussions around a successful application for grant funding from research and commercial opportunities. QBI also Biopharmaceuticals Australia (BPA). Another patent exhibited as part of the Life Science Queensland for a potential treatment for spinal cord injury or delegation and looks forwards to attending the neurodegenerative disorders (c29 peptide), based 2015 event in Philadelphia. on the discovery of a mechanism for preventing apoptotic cell death, has progressed to in vivo test- UniQuest will continue to work alongside the Insti- ing. NuNerve Pty Ltd, the QBI spin-out company tute’s research teams to pursue any commercial supported this through an ARC linkage grant that opportunities arising from the researchers. To fur- finished in 2014. ther support this, UniQuest provides educational support to QBI’s postgraduate and early career Three patents licenced to NuNerve (neural stem cell researchers about how they can use technology generation, methods of isolating stem cells, and transfer to ensure their research has commercial factors that promote the generation and survival potential. One way that this can be achieved is of endogenous neural stem cells for therapeutic through attending UniQuest’s annual commer- benefit in dementia) have continued to be main- cialisation workshop which provides researchers tained and will be reviewed in 2015. with the opportunity to receive expert advice Other projects with potential commercial value and guidance from professionals working in the that were progressed in 2014 included a discov- pharmaceutical, biotechnology, investment, IP and ery around the use of kinase inhibitors to prevent research sectors.

Left: Ultrasound can be used to clear amyloid plaques in the brain.

RECOGNITION 70 Publications Publications

QBI researchers (indicated in bold) contributed Baumann O, Borra RJ, Bower JM, Cullen KE, Habas Bhagavatula PS, Claudianos C, Ibbotson MR & Byrne EM [for the Psychiatric Genetics Consor- to the following publications, published either C, Ivry RB, Leggio M, Mattingley JB, Molinari M, Srinivasan MV (2014) Behavioral lateralization tium Major Depressive Disorder Working Group], in print or electronically, in 2014. Moulton EA, Paulin MG, Pavlova MA, Schmah- and optimal route choice in flying budgerigars. Raheja UK, Stephens SH, Heath AC, Madden PA, Publications that were omitted from the 2013 mann JD & Sokolov AA (2014) Consensus paper: PLOS Computational Biology 10: e1003473. Vaswani D, Nijjar GV, Ryan KA, Youssufi H, Gehr- Annual Report are also included. the role of the cerebellum in perceptual pro- Bode AS & Lynch JW (2014) The impact of human man PR, Shuldiner AR, Martin NG, Montgomery cesses. Cerebellum doi: 10.1007/s12311-014-0627-7 GW, Wray NR, Nelson EC, Mitchell BD & Postol- S next to an author indicates the author is or was hyperekplexia mutations on glycine receptor [Epub ahead of print] ache TT (2014) Seasonality shows evidence for enrolled as a research higher degree student structure and function. Molecular Brain 7: 2. polygenic architecture and genetic correlation at QBI. Baumann O & Mattingley JB (2014) Dissociable S, , , S, Boskovic Z Alfonsi F Rumballe BA Fonseka S with schizophrenia and bipolar disorder. Journal roles of the hippocampus and parietal cortex in Windels F & Coulson EJ (2014) The role of p75NTR Aggarwal M, S, & Mori S (2014) of Clinical Psychiatry doi: 10.4088/JCP.14m08981 Gobius I Richards LJ processing of coordinate and categorical spatial in cholinergic basal forebrain structure and func- Diffusion MR microscopy of cortical develop- [Epub ahead of print] information. Frontiers in Human Neuroscience tion. Journal of Neuroscience 34: 13033-13038. ment in the mouse embryo. Cerebral Cortex 8: 73. Byrne EM, Carrillo-Roa T, Penninx BWJH, Sallis , , & Smith doi:10.1093/cercor/bhu006 [Epub ahead of print] Brion M-JA Benyamin B Visscher PM HM, Viktorin A, Chapman B, Henders AK, Psy- Bednark JG & Franz EA (2014) Agency attribution: GD (2014) Beyond the single SNP: emerging Al-Chalabi A & (2014) Motor neuron chiatric Genome Consortium Major Depressive Visscher PM event-related potentials and outcome monitor- developments in mendelian randomization in disease: common genetic variants and the her- Disorders Working Group, Pergadia ML, Heath ing. Experimental Brain Research 232: 1117-1126. the “omics” era. Current Epidemiology Reports itability of ALS. Nature Reviews Neurology 10: AC, Madden PAF, Sullivan PF, Boschloo L, van Bell KL, Rangan H, Fowler R, Kull CA, Pettigrew JD, 1: 228-236. 549-550. Grootheest G, McMahon G, Lawlor DA, Landén Vickers CE & Murphy DL (2014) Genetic diver- S Brombas A, Fletcher LN & Williams SR (2014) M, Lichtenstein P, Magnusson PKE, Evans DM, An JYS, Cristino AS, Zhao Q, Edson J, Williams sity and biogeography of the boab Adansonia Activity-dependent modulation of layer 1 inhibi- Montgomery GW, Boomsma DI, Martin NG, S, Ravine D, Wray J, , Hunt A, SM Marshall VM gregorii (Malvaceae: Bombacoideae). Australian tory neocortical circuits by acetylcholine. Journal Whitehouse AJ & (2014) Towards a Meltzer-Brody S & Wray NR (2014) Applying Claudianos C Journal of Botany 62: 164–174. of Neuroscience 34: 1932-1941. molecular characterization of autism spectrum polygenic risk scores to postpartum depression. Benyamin B, Esko T, Ried JS, Radhakrishnan A, disorders: an exome sequencing and systems Brooks K, Ranall M, Spoerri L, Stevenson A, Archives of Women’s Mental Health 17: 519-528. Vermeulen SH, Traglia M, Gögele M, Anderson approach. Translational Psychiatry 4: e394. Gunasingh G, Pavey S, Meunier F, Gonda TJ & Byrne EM, Heath AC, Madden PAF, Pergadia ML, D, Broer L, Podmore C, Luan J, Kutalik Z, Sanna Gabrielli B (2014) Decatenation checkpoint-de- Hickie IB, Montgomery GW, Martin NG & Wray Ball D, Kliese R, Windels F, Nolan C, Stratton P, S, van der Meer P, Tanaka T, Wang F, Westra fective melanomas are dependent on PI3K for NR (2014) Testing the role of circadian genes Sah P & Wiles J (2014) Rodent scope: a user-con- H-J, Franke L, Mihailov E, Milani L, Häldin J, survival. Pigment Cell and Melanoma Research in conferring risk for psychiatric disorders. figurable digital wireless telemetry system for Winkelmann J, Meitinger T, Thiery J, Peters A, 27: 813–821. American Journal of Medical Genetics Part B: freely behaving animals. PLOS ONE 9: e89949. Waldenberger M, Rendon A, Jolley J, Sambrook J, Brunck MEG, Andersen SB, Timmins NE, Osborne Neuropsychiatric Genetics 165: 254–260. Bartlett PF & He RQ (2014) Introduction to the Kiemeney LA, Sweep FC, Sala CF, Schwienbacher GW & Nielsen LK (2014) Absolute counting of thematic issue “From brain function to therapy”. C, Pichler I, Hui J, Demirkan A, Isaacs A, Amin N, Catalá-López F, Suárez-Pinilla M, Suárez-Pinilla P, neutrophils in whole blood using flow cytometry. Science China Life Sciences 57: 363-365. Steri M, Waeber G, Verweij N, Powell JE, Nyholt Valderas JM, Gómez-Beneyto M, Martinez S, Bal- Cytometry Part A 85A: 1057-1064. DR, Heath AC, Madden PAF, , Wright anza-Martínez V, Climent J, Valencia A, McGrath Bauer N, Pathirana P, Ekanayake S & Srinivasan Visscher PM MJ, Montgomery GW, Martin NG, Hernandez Burne THJ, Alexander S, Turner KMS, Eyles DW J, Crespo-Facorro B, Sanchez-Moreno J, Vieta E M (2014) Convergence of object focused simul- & McGrath JJ (2014) Developmentally vitamin & Tabaŕes-Seisdedos R (2014) Inverse and direct taneous estimation of optical flow and state D, Bandinelli S, van der Harst P, Uda M, Vollen- D-deficient rats show enhanced prepulse inhi- cancer comorbidity in people with central nerv- dynamics. International Journal of Advanced weider P, Scott RA, Langenberg C, Wareham bition after acute Δ9-tetrahydrocannabinol. ous system disorders: a meta-analysis of cancer Robotic Systems 11: 158. NJ, InterAct Consortium, van Duijn C, Beilby J, Pramstaller PP, Hicks AA, Ouwehand WH, Oexle Behavioural Pharmacology 25: 236-244. incidence in 577,013 participants of 50 observa- K, Gieger C, Metspalu A, Camaschella C, Toniolo tional studies. Psychotherapy Psychosomatics D, Swinkels DW & Whitfield JB (2014) Novel loci 83: 89-105. affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nature Communications 5: 4926.

71 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Publications

Chadderton P, Schaefer AT, Williams SR & Margrie Chen XJ, Xu H, Cooper HM & Liu Y (2014) Cytoplas- The Coffee and Caffeine Genetics Consortium et TW (2014) Sensory-evoked synaptic integration mic dynein: a key player in neurodegenerative al. [includes Byrne EM] (2014) Genome-wide in cerebellar and cerebral cortical neurons. and neurodevelopmental diseases. Science China meta-analysis identifies six novel loci associated Nature Reviews Neuroscience 15: 71-83. Life Sciences 57: 372–377. with habitual coffee consumption. Molecular Champ CS, Wallis G, Vorobyev M, Siebeck U & Cheney KL, Cortesi F, How MJ, Wilson NG, Blomb- Psychiatry doi:10.1038/mp.2014.107. [Epub ahead Marshall J (2014) Visual acuity in a species of erg SP, Winters AE, Umanzör S & Marshall of print] coral reef fish: Rhinecanthus aculeatus. Brain, NJ (2014) Conspicuous visual signals do not Contreras-Huerta LSS, Hielscher E, Sherwell CSS, Behavior and Evolution 83: 31-42. coevolve with increased body size in marine Rens NS & Cunnington R (2014) Intergroup rela- Chand KK, Lee KM, Schenning MP, Lavidis NA & sea slugs. Journal of Evolutionary Biology 27: tionships do not reduce racial bias in empathic Noakes PG (2015) Loss of β2-laminin alters 676-687. neural responses to pain. Neuropsychologia 64: calcium sensitivity and voltage gated calcium Cheung A (2014) Estimating location without 263-270. channel maturation of neurotransmission at the external cues. PLOS Computational Biology 10: Cooray G, Garrido MI, Hyllienmark L & Brismar neuromuscular junction. Journal of Physiology e1003927. T (2014) A mechanistic model of mismatch 593: 245-265. [Epub 2014] Cheung A, Collett M, Collett TS, Dewar A, Dyer F, negativity in the ageing brain. Clinical Neuro- Chen G-B (2014) Estimating heritability of complex Graham P, Mangan M, Narendra A, Philippides A, physiology 125: 1774–1782. traits from genome-wide association studies Stürzl W, Webb B, Wystrach A & Zeil J (2014) Still Cornes E, Quéré CAL, Giordano-Santini R & Dupuy using IBS-based Haseman-Elston regression. no convincing evidence for cognitive map use by D (2014) Applying antibiotic selection markers Frontiers in Genetics 5: 107. honeybees. Proceedings of the National Acad- for nematode genetics. Methods 68: 403–408. emy of Sciences of the USA 111: E4396-E4397. Chen G-B (2014) Where is the friend’s home? Fron- Chung W-SS & Marshall J (2014) Cortesi F, Musilova Z, Stieb SM, Hart NS, Sie- tiers in Genetics 5: 400. Chew YL, Fan X, Götz J & Nicholas HR (2014) Regula- Range-finding in squid using retinal beck UE, Malmstrom M, Torresen OK, Jentoft Chen G-B, Lee SH, Brion M-JA, Montgomery GW, tion of age-related structural integrity in neurons deformation and image blur. Current S, Cheney KL, Marshall NJ, Carleton KL & Salz- Wray NR, Radford-Smith GL, Visscher PM & The by protein with tau-like repeats (PTL-1) is cell Biology 24: R64. burger W (2014) Ancestral duplications and International IBD Genetics Consortium (2014) autonomous. Scientific Reports 4: 5185. highly dynamic opsin gene evolution in per- Estimation and partitioning of (co)heritability Chung W-SS, Marshall NJ, Watson S-A, Munday comorph fishes. Proceedings of the National Claudianos C, Lim J, Young M, Yan S, Cristino of inflammatory bowel disease from GWAS and PL & Nilsson GE (2014) Ocean acidification Academy of Sciences of the USA doi: 10.1073/ AS, Newcomb RD, Gunasekaran N & Rein- immunochip data. Human Molecular Genetics slows retinal function in a damselfish through pnas.1417803112 [Epub ahead of print] hard J (2014) Odor memories regulate olfactory 23: 4710–4720. interference with GABA receptors. Journal of Cottrell D & Campbell ME (2014) Auditory percep- A receptor expression in the sensory periphery. Experimental Biology 217: 323-326. tion of a human walker. Perception 43: 1225-1238. Chen J, Sun M, Wang X, Lu J, Wei Y, Tan Y, Liu European Journal of Neuroscience 39: 1642-1654. Y, Götz J, He RQ & Hua Q (2014) The herbal Clark CES, Liu Y & Cooper HM (2014) The Yin and Cristino AS, Barchuk AR, Freitas FCP, Narayanan Cocchi L, Harding IH, Lord A, Pantelis C, Yucel M compound geniposide rescues formaldehyde-in- Yang of Wnt/Ryk axon guidance in development RKS, Biergans SD, Zhao Z, Simoes ZLP, & Zalesky A (2014) Disruption of structure-func- duced apoptosis in N2a neuroblastoma cells. and regeneration. Science China Life Sciences Reinhard J & Claudianos C (2014) Neuroli- tion coupling in the schizophrenia connectome. Science China Life Sciences 57: 412–421. 57: 366-371. gin-associated microRNA-932 targets actin Neuro Clinical 4: 779-787. Clark CEJS, Richards LJ, Stacker SA & Cooper HM and regulates memory in the honeybee. Nature Coelho CM & Balaban CD (2015) Visuo-vestibular (2014) Wnt5a induces Ryk-dependent and -inde- Communications 5: 5529. contributions to anxiety and fear. Neuroscience pendent effects on callosal axon and dendrite and Biobehavioral Reviews 48: 148-159. [Epub growth. Growth Factors 32: 11-17. 2014]

RECOGNITION 72 Publications Publications

Cui X, Lefevre ES, Turner KMS, Coelho CM, Dean AJ, Bor W, Adam K, Bowling FG & Bellgrove Edwards SR, Hamlin AS, Marks NS, Coulson EJ Alexander S, Burne THJ & Eyles DW (2015) MA (2014) A randomized, controlled, crossover & Smith MT (2014) Comparative studies using MK-801-induced behavioural sensitisation alters trial of fish oil treatment for impulsive aggres- the Morris water maze to assess spatial memory dopamine release and turnover in rat prefron- sion in children and adolescents with disruptive deficits in two transgenic mouse models of tal cortex. Psychopharmacology 232: 509-517. behavior disorders. Journal of Child and Adoles- Alzheimer’s disease. Clinical and Experimental [Epub 2014] cent Psychopharmacology 24: 140-148. Pharmacology and Physiology 41: 798-806. Cullen CL, Burne THJ, Lavidis NA & Moritz KM Dietz MJ, Friston KJ, Mattingley JB, Roepstorff A & Evangelista C, Kraft P, Dacke M, Labhart T & (2014) Low dose prenatal alcohol exposure Garrido MI (2014) Effective connectivity reveals Srinivasan MV (2014) Honeybee navigation: does not impair spatial learning and memory right-hemisphere dominance in audiospatial critically examining the role of the polarization in two tests in adult and aged rats. PLOS ONE perception: implications for models of spatial compass. Philosophical Transactions of the Royal 9: e101482. neglect. Journal of Neuroscience 34: 5003-5011. Society B: Biological Sciences 369: 20130037. Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Dixon CS, Sah P, Lynch JW & Keramidas A (2014)

Lu H, Liu Y, Tsai PC, Collier DA, Murphy T, Demp- GABAA receptor α- and γ- subunits shape synap- ster E, Mill J, UK Brain Expression Consortium, tic currents via different mechanisms. Journal of Battle A, Mostafavi S, Zhu X, Henders A, Byrne Biological Chemistry 289: 5399-5411. E, Wray NR, Martin NG, Spector TD & Wang J Dong H, Chen M, Rahman S, Parekh HS, Cooper (2014) Hypermethylation in the ZBTB20 gene HM & Xu ZP (2014) Engineering small MgAl-lay- is associated with major depressive disorder. ered double hydroxide nanoparticles for Genome Biology 15: R56. enhanced gene delivery. Applied Clay Science Davis J, Maes M, Andreazza A, McGrath JJ, Tye 100: 66-75. Cronin TW, Johnsen S, Marshall NJ SJ & Berk M (2014) Towards a classification of Dougherty LF, Johnsen S, Caldwell RL & Marshall & Warrant EJ. (2014). Visual Ecology. Prince- biomarkers of neuropsychiatric disease: from NJ (2014) A dynamic broadband reflector built ton, NJ: Princeton University Press [Book] encompass to compass. Molecular Psychiatry from microscopic silica spheres in the ‘disco’ doi:10.1038/mp.2014.139. [Epub ahead of print] clam Ctenoides ales. Journal of the Royal Society: de Busserolles F, Fitzpatrick JL, Marshall NJ & Interface 11: 20140407. Cronin TW, Bok MJ, & Caldwell RL Marshall NJ Collin SP (2014) The influence of photoreceptor (2014) Filtering and polychromatic vision in Duan J, Shi J, Fiorentino A, Leites C, Chen X, Moy W, size and distribution on optical sensitivity in mantis shrimps: themes in visible and ultraviolet Chen J, Alexandrov BS, Usheva A, He D, Freda J, the eyes of lanternfishes (Myctophidae). PLOS vision. Philosophical Transactions of the Royal O’Brien NL, MGS Consortium [includes Mowry, ONE 9: e99957. Society B: Biological Sciences 369: 20130032. BJ], GPC, McQuillin A, Sanders AR, Gershon ES, de Busserolles F, Marshall NJ & Collin SP (2014) DeLisi LE, Bishop AR, Gurling HM, Pato MT, Lev- , S, S, , , S Cui X Gooch H Groves NJ Sah P Burne TH The eyes of lanternfishes (Myctophidae, Tele- inson DF, Kendler KS, Pato CN & Gejman PV Edwards TJ , Sherr EH, Barkovich AJ & & (2014) Vitamin D and Eyles DW McGrath JJ ostei): novel ocular specializations for vision in (2014) A rare functional noncoding variant at Richards LJ (2014) Clinical, genetic and the brain: key questions for future research. dim light. Journal of Comparative Neurology the GWAS-implicated MIR137/MIR2682 locus imaging findings identify new causes for Journal of Steroid Biochemistry and Molecular 522: 1618-1640. might confer risk to schizophrenia and bipolar corpus callosum development syndromes. Biology doi: 10.1016/j.jsbmb.2014.11.004. [Epub disorder. American Journal of Human Genetics Brain 137: 1579-1613. ahead of print] de Busserolles F, Marshall NJ & Collin SP (2014) Retinal ganglion cell distribution and spatial 95: 744-753. resolving power in deep-sea lanternfishes (Myctophidae). Brain, Behavior and Evolution 84: 262-276.

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Fenton GE, Pollard AK, Halliday DM, Mason R, Garvert MM, Friston KJ, Dolan RJ & Garrido MI Gusev A, Lee SH, Trynka G, Finucane H, Vilhjalms- Bredy TW & Stevenson CW (2014) Persistent (2014) Subcortical amygdala pathways enable son BJ, Xu H, Zang C, Ripke S, Bulik-Sullivan B, prelimbic cortex activity contributes to enhanced rapid face processing. NeuroImage 102: 309-316. Stahl E, Schizophrenia Working Group of the learned fear expression in females. Learning and Giacomantonio CES & Goodhill GJ (2014) A Psychiatric Genomics Consortium [includes Memory 21: 55-60. computational model of the effect of gene Mowry, BJ & Visscher, PM], SWE-SCZ Con- Filmer HL, Mattingley JB & Dux PE (2014) Size misexpression on the development of cortical sortium, Kahler AK, Hultman CM, Purcell SM, (mostly) doesn’t matter: the role of set size in areas. Biological Cybernetics 108: 203-221. McCarroll SA, Daly M, Pasaniuc B, Sullivan PF, Neale BM, Wray NR, Raychaudhuri S & Price object substitution masking. Attention, Percep- (2014) Open access: Practical costs of Goodhill GJ AL (2014) Partitioning heritability of regulatory tion, & Psychophysics 76: 1620–1629. data sharing. Nature 509: 33. and cell-type-specific variants across 11 common Filmer HL, & Dux PE (2015) Object Mattingley JB Gottlieb DJ, Hek K, Chen TH, Watson NF, Eiriksdottir diseases. American Journal of Human Genetics substitution masking for an attended and fove- G, Byrne EM, Cornelis M, Warby SC, Bandinelli 95: 535-552. ated target. Journal of Experimental Psychology: S, Cherkas L, Evans DS, Grabe HJ, Lahti J, Li M, Harper CB, Bademosi AT, Coulson EJ & Meunier Human Perception and Performance 41: 6-10. Lehtimaki T, Lumley T, Marciante KD, Perusse FA (2014) A role for SNAREs in neuronal survival? Foley DL, Mackinnon A, Morgan VA, Watts GF, L, Psaty BM, Robbins J, Tranah GJ, Vink JM, Wilk Journal of Neurochemistry 129: 753–755. McGrath JJ, Castle DJ, Waterreus A & Galletly JB, Stafford JM, Bellis C, Biffar R, Bouchard C, CA (2014) Predictors of type 2 diabetes in a Cade B, Curhan GC, Eriksson JG, Ewert R, Ferrucci Harris J & Kamke MR (2014) Electrophysiological nationally representative sample of adults with L, Fulop T, Gehrman PR, Goodloe R, Harris TB, evidence for altered visual, but not auditory, psychosis. World Psychiatry 13: 176-183. Heath AC, Hernandez D, Hofman A, Hottenga JJ, selective attention in adolescent cochlear Hunter DJ, Jensen MK, Johnson AD, Kahonen M, implant users. International Journal of Pediatric Filmer HL, Dux PE & Mattingley JB (2014) Frank SM, Baumann O, Mattingley JB & Green- Kao L, Kraft P, Larkin EK, Lauderdale DS, Luik AI, Otorhinolaryngology 78: 1908-1916. Applications of transcranial direct current lee MW (2014) Vestibular and visual responses Medici M, Montgomery GW, Palotie A, Patel SR, Harris L, Genovesi LA, Gronostajski RM, Wain- stimulation for understanding brain func- in human posterior insular cortex. Journal of Pistis G, Porcu E, Quaye L, Raitakari O, Redline wright BJ & Piper M (2015) Nuclear factor one tion. Trends in Neurosciences 37: 742-753. Neurophysiology 112: 2481-2491. S, Rimm EB, Rotter JI, Smith AV, Spector TD, transcription factors: divergent functions in Frost B, & Feany MB (2015) Connecting the Götz J Teumer A, Uitterlinden AG, Vohl MC, Widen E, developmental versus adult stem cell popula- dots between tau dysfunction and neurode- Evans DM, , Paternoster L, Kemp JP, McMa- Willemsen G, Young T, Zhang X, Liu Y, Blangero tions. Developmental Dynamics 244: 227-238. Brion MJ generation. Trends in Cell Biology 25: 46-53. hon G, Munafo M, Whitfield JB, Medland SE, J, Boomsma DI, Gudnason V, Hu F, Mangino M, [Epub 2014] Harrison WJ, Remington RW & Mattingley JB (2014) Montgomery GW, Timpson NJ, St Pourcain B, Martin NG, O’Connor GT, Stone KL, Tanaka T, Visual crowding is anisotropic along the hori- Futema M, , Cooper JA, Li K, Whittall RA, Lawlor DA, Martin NG, Dehghan A, Hirschhorn Shah S Viikari J, Gharib SA, Punjabi NM, Raikkonen K, zontal meridian during smooth pursuit. Journal Sharifi M, Goldberg O, Drogari E, Mollaki V, Wieg- J & Davey Smith G (2013) Mining the human Volzke H, Mignot E & Tiemeier H (2014) Novel of Vision 14: 21. phenome using allelic scores that index biolog- man A, Defesche J, D’Agostino MN, D’Angelo A, loci associated with usual sleep duration: the He J, Mangelsdorf M, Fan D, Bartlett P & Brown ical intermediates. PLOS Genetics 9: e1003919. Rubba P, Fortunato G, Walus-Miarka M, Hegele CHARGE Consortium Genome-Wide Associa- MA (2014) Amyotrophic lateral sclerosis genetic RA, Aderayo Bamimore M, Durst R, Leitersdorf tion Study. Molecular Psychiatry doi: 10.1038/ Eyles DW, Liu P-Y, Josh P & Cui X (2014) Intracellu- studies: from genome-wide association map- E, Mulder MT, Roeters van Lennep JE, Sijbrands mp.2014.133. [Epub ahead of print] lar distribution of the vitamin D receptor in the EJ, Whittaker JC, Talmud PJ & Humphries SE ping to genome sequencing. Neuroscientist brain: comparison with classic target tissues and Gratten J, Wray NR, Keller MC & Visscher PM (2015) Refinement of variant selection for the doi:10.1177/1073858414555404 [Epub ahead of redistribution with development. Neuroscience (2014) Large-scale genomics unveils the genetic LDL cholesterol genetic risk score in the diag- print] 268: 1–9. architecture of psychiatric disorders. Nature Neu- nosis of the polygenic form of clinical familial roscience 17: 782-790. Faridar A, Jones-Davis D, Rider E, Li J, Gobius IS, hypercholesterolemia and replication in samples S Morcom L, Richards L, Sen S & Sherr E (2014) from 6 countries. Clinical Chemistry 61: 231-238. Groves NJ , McGrath JJ & Burne THJ (2014) Vita- Mapk/Erk activation in an animal model of social [Epub 2014] min D as a neurosteroid affecting the developing deficits shows a possible link to autism. Molec- and adult brain. Annual Review of Nutrition 34: ular Autism 5: 57. 117-141.

RECOGNITION 74 Publications Publications

Heap LA, Goh CC, Kassahn KS & Scott EK (2013) Hill WD, Davies G, van de Lagemaat LN, Christo- Hopping G, Wang C-IA, Hogg RC, Nevin ST, Lewis Cerebellar output in zebrafish: an analysis of forou A, Marioni RE, Fernandes CPD, Liewald RJ, Adams DJ & Alewood PF (2014) Hydropho- spatial patterns and topography in eurydendroid DC, Croning MDR, Payton A, Craig LCA, Whalley bic residues at position 10 of α-conotoxin PnIA cell projections. Frontiers in Neural Circuits 7: 53. LJ, Horan M, Ollier W, Hansell NK, Wright MJ, influence subtype selectivity between α7 and Heath AK, Williamson EJ, Ebeling PR, Kvaskoff D, Martin NG, Montgomery GW, Steen VM, Le α3β2 neuronal nicotinic acetylcholine receptors. Eyles DW & English DR (2014) Measurements of Hellard S, Espeseth T, Lundervold AJ, Reinvang Biochemical Pharmacology 91: 534–542. 25-hydroxyvitamin D concentrations in archived I, Starr JM, Pendleton N, Grant SGN, Bates TC Hovestadt V, Jones DT, Picelli S, Wang W, Kool M, dried blood spots are reliable and accurately & Deary IJ (2014) Human cognitive ability is Northcott PA, Sultan M, Stachurski K, Ryzhova reflect those in plasma. Journal of Clinical Endo- influenced by genetic variation in components M, Warnatz HJ, Ralser M, Brun S, Bunt J, Jager crinology and Metabolism 99: 3319-3324. of postsynaptic signalling complexes assem- N, Kleinheinz K, Erkek S, Weber UD, Bartholo- bled by NMDA receptors and MAGUK proteins. Hemani G, Shakhbazov K, Westra H-J, Esko T, mae CC, von Kalle C, Lawerenz C, Eils J, Koster J, Translational Psychiatry 4: e341. Henders AK, McRae AF, Yang J, Gibson G, Martin Versteeg R, Milde T, Witt O, Schmidt S, Wolf S, NG, Metspalu A, Franke L, Montgomery GW, Hoggart CJ, Venturini G, Mangino M, Gomez Pietsch T, Rutkowski S, Scheurlen W, Taylor MD, Visscher PM & Powell JE (2014) Hemani et al. F, Ascari G, Zhao JH, Teumer A, Winkler TW, Brors B, Felsberg J, Reifenberger G, Borkhardt A, reply. Nature 514: E5-E6. Tšernikova N, Luan J, Mihailov E, Ehret GB, Zhang Lehrach H, Wechsler-Reya RJ, Eils R, Yaspo ML, W, Lamparter D, Esko T, Macé A, Rüeger S, Landgraf P, Korshunov A, Zapatka M, Radlwim- Hemani G, Shakhbazov K, Westra H-J, Esko T, Bochud P-Y, Barcella M, Dauvilliers Y, Benyamin mer B, Pfister SM & Lichter P (2014) Decoding Henders AK, McRae AF, Yang J, Gibson G, Martin B, Evans DM, Hayward C, Lopez MF, Franke L, the regulatory landscape of medulloblastoma NG, Metspalu A, Franke L, Montgomery GW, Russo A, Heid IM, Salvi E, Vendantam S, Arking using DNA methylation sequencing. Nature 510: Visscher PM & Powell JE (2014) Detection and DE, Boerwinkle E, Chambers JC, Fiorito G, Grallert 537–541. replication of epistasis influencing transcription H, Guarrera S, Homuth G, Huffman JE, Porte- in humans. Nature 508: 249–253. How MJ, Christy J, Roberts NW & Marshall NJ ous D, Generation Scotland Consortium, The (2014) Null point of discrimination in crustacean Heng YH, Zhou B, Harris L, Harvey T, Smith A, LifeLines Cohort study, The Giant Consortium, polarisation vision. Journal of Experimental Biol- Hunt DM, Hankins MW, Collin SP & Mar- Horne E, Martynoga B, Andersen J, Achimastou Moradpour D, Iranzo A, Hebebrand J, Kemp JP, ogy 217: 2462-2467. shall NJ (Eds.). (2014) Evolution of Visual A, Cato K, Richards LJ, Gronostajski RM, Yeo GS, Lammers GJ, Aubert V, Heim MH, Martin NG, , Porter ML, Radford AN, Feller KD, Temple and Non-visual Pigments. New York: Guillemot F, Bailey TL & Piper M (2014) NFIX Montgomery GW, Peraita-Adrados R, Santamaria How MJ SE, Caldwell RL, , Cronin TW & Rob- Springer [Book] regulates proliferation and migration within the J, Negro F, Schmidt CO, Scott RA, Spector TD, Marshall NJ erts NW (2014) Out of the blue: the evolution murine SVZ neurogenic niche. Cerebral Cortex Strauch K, Völzke H, Wareham NJ, Yuan W, Bell of horizontally polarized signals in Haptosquilla doi:10.1093/cercor/bhu253 [Epub ahead of print] JT, Chakravarti A, Kooner JS, Peters A, Matullo Hughes NJS, Hunt JJ, Cloherty SL, Ibbotson MR, (Crustacea, Stomatopoda, Protosquillidae). Jour- Herder C, Nuotio ML, Shah S, Blankenberg S, Brun- G, Wallaschofski H, Whitfield JB, Paccaud F, Vol- Sengpiel F & Goodhill GJ (2014) Stripe-rearing nal of Experimental Biology 217: 3425-3431. ner EJ, Carstensen M, Gieger C, Grallert H, Jula lenweider P, Bergmann S, Beckmann JS, Tafti changes multiple aspects of the structure of S S A, Kahonen M, Kettunen J, Kivimaki M, Koenig M, Hastie ND, Cusi D, Bochud M, Frayling TM, Huang S-C , Chiou T-H , Marshall J & Reinhard primary visual cortex. NeuroImage 95: 305-319. J (2014) Spectral sensitivities and color signals in W, Kristiansson K, Langenberg C, Lehtimaki T, Metspalu A, Jarvelin M-R, Scherag A, Smith GD, Hussain NK, Diering GH, Sole J, Anggono V & a polymorphic damselfly. PLOS ONE 9: e87972. Luotola K, Marzi C, Muller C, Peters A, Prokisch Borecki IB, Rousson V, Hirschhorn JN, Rivolta C, Huganir RL (2014) Sorting Nexin 27 regulates H, Raitakari O, Rathmann W, Roden M, Salmi Loos RJF & Kutalik Z (2014) Novel approach iden- Hughes NJS & Goodhill GJ (2015) Optimizing the basal and activity-dependent trafficking of M, Schramm K, Swerdlow D, Tabak AG, Thorand tifies SNPs in SLC2A10 and KCNK9 with evidence representation of orientation preference maps AMPARs. Proceedings of the National Academy B, Wareham N, Wild PS, Zeller T, Hingorani AD, for parent-of-origin effect on body mass index. in visual cortex. Neural Computation 27: 32-41. of Sciences of the USA 111: 11840–11845. Witte DR, Kumari M, Perola M & Salomaa V PLOS Genetics 10: e1004508. [Epub 2014] (2014) Genetic determinants of circulating Hollins SL, Goldie BJ, Carroll AP, Mason EA, Walker interleukin-1 receptor antagonist levels and FR, Eyles DW & Cairns MJ (2014) Ontogeny of their association with glycemic traits. Diabetes small RNA in the regulation of mammalian brain 63: 4343-4359. development. BMC Genomics 15: 777.

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Imai R, Hayashida K, Nakano H & Morioka S (2014) Jiang T (2014) Brainnetome and related projects. Klengel T, Pape J, Binder EB & Mehta D (2014) The Brain activity associated with the illusion of Science China Life Sciences 57: 462-466. role of DNA methylation in stress-related psychi- motion evoked by different vibration stimula- Joilin G, Guévremont D, Ryan B, Claudianos C, atric disorders. Neuropharmacology 80: 115–132. tion devices: an fNIRS study. Journal of Physical Cristino AS, Abraham WC & Williams JM (2014) Köhler C, Dinekov M & Götz J (2014) Granulovacuo- Therapy Science 26: 1115-1119. Rapid regulation of microRNA following induc- lar degeneration and unfolded protein response Isaac SM, Langford MB, Simmons DG & Adam- tion of long-term potentiation in vivo. Frontiers in mouse models of tauopathy and Aβ amy- son SL. (2014). Anatomy of the mouse placenta in Molecular Neuroscience 7: 98. loidosis. Neurobiology of Disease 71: 169-179. throughout gestation. In BA Croy, AT Yamada, Jones AL, Mowry BJ, McLean DE, Mantzioris BX, Kottler B & van Swinderen B (2014) Taking a new F DeMayo & SL Adamson (Eds.), The guide to Pender MP & Greer JM (2014) Elevated levels of look at how flies learn. eLife 3: e03978. investigation of mouse pregnancy (pp. 69-73). autoantibodies targeting the M1 muscarinic ace- Laurent V, , Chieng BC & Amsterdam: Academic Press [Book chapter] Bertran-Gonzalez J tylcholine receptor and neurofilament medium Balleine BW (2014) δ-opioid and dopaminergic Ittner A, Bertz J, Suh LS, Stevens CH, Götz J & in sera from subgroups of patients with schiz- processes in accumbens shell modulate the Ittner LM (2015) Tau-targeting passive immu- ophrenia. Journal of Neuroimmunology 269: cholinergic control of predictive learning and nization modulates aspects of pathology in tau 68-75. choice. Journal of Neuroscience 34: 1358-1369. transgenic mice. Journal of Neurochemistry 132: Kamke MR & Harris J (2014) Contingent capture Lee H, Kim SA, Coakley SS, Mugno P, Hammarlund 135-145. [Epub 2014] of involuntary visual attention interferes with M, Hilliard MA & Lu H (2014) A multi-channel Jhaveri DJ, Nanavaty I, Prosper BW, Marathe S, detection of auditory stimuli. Frontiers in Psy- device for high-density target-selective stimu- Husain BFA, Kernie SG, Bartlett PF & Vaidya VA chology 5: 528. lation and long-term monitoring of cells and Keshavarzi SS, Sullivan RK, Ianno DJ (2014) Opposing effects of α2- and β-adrenergic Kamke MR, Ryan AE, Sale MV, Campbell MEJS, subcellular features in C. elegans. Lab on a Chip & Sah P (2014) Functional properties and receptor stimulation on quiescent neural pre- Riek S, Carroll TJ & Mattingley JB (2014) Visual 14: 4513-4522. projections of neurons in the medial cursor cell activity and adult hippocampal spatial attention has opposite effects on bidi- amygdala. Journal of Neuroscience 34: Levinson DF, Mostafavi S, Milaneschi Y, Rivera M, neurogenesis. PLOS ONE 9: e98736. rectional plasticity in the human motor cortex. 8699-8715. Ripke S, Wray NR & Sullivan PF (2014) Genetic Jiang L, Yin J, Ye L, Yang J, Hemani G, Liu AJ, Zou Journal of Neuroscience 34: 1475-1480. studies of major depressive disorder: why are H, He D, Sun L, Zeng X, Li Z, Zheng Y, Lin Y, Liu Kamke MR, Van Luyn J, Constantinescu G & Harris there no genome-wide association study find- Y, Fang Y, Xu J, Li Y, Dai SM, Guan J, Jiang L, Wei J (2014) Contingent capture of involuntary visual Kita EMS, Scott EK & Goodhill GJ (2014) The ings and what can we do about it? Biological Q, Wang Y, Li Y, Huang C, Zuo X, Liu Y, Wu X, spatial attention does not differ between nor- influence of activity on axon pathfinding in the Psychiatry 76: 510-512. Zhang L, Zhou L, Zhang Q, Li T, Chen L, Xu Z, mally hearing children and proficient cochlear optic tectum. Developmental Neurobiology doi: S, Wei W, Zhao Q-Y, Widagdo J, Baker-An- Yang X, Qian F, Xie W, Liu W, Guo Q, Huang S, Li X implant users. Restorative Neurology and Neu- 10.1002/dneu.22262 [Epub ahead of print] dresen DS, Flavell CR, D’Alessio A, Zhang Y Zhao J, Li M, Jin Y, Gao J, Lv Y, Wang Y, Lin L, roscience 32: 799-811. Kiuchi T, Ortiz-Zapater E, Monypenny J, Matthews & Bredy TW (2014) Neocortical Tet3-mediated Guo A, Danoy P, Willner D, Cremin C, Hadler S, Fripp J, Rowe CC, Villemagne VL, DR, Nguyen LK, Barbeau J, Coban O, Lawler K, accumulation of 5-hydroxymethylcytosine pro- J, Zhang F, Zhao Y, Li M, Yue T, Fan X, Guo J, Kerbler GM Salvado O, Rose S & Coulson EJ (2015) Basal Burford B, Rolfe DJ, de Rinaldis E, Dafou D, motes rapid behavioral adaptation. Proceedings Mu R, Li J, Wu C, Zeng M, Wang J, Li S, Jin L, forebrain atrophy correlates with amyloid β Simpson MA, Woodman N, Pinder S, Gillett of the National Academy of Sciences of the USA Wang B, Wang J, Ma X, Sun L, Zhang X, Brown burden in Alzheimer’s disease. NeuroImage: CE, Devauges V, Poland SP, Fruhwirth G, Marra 111: 7120-7125. MA, Visscher PM, Su DF & Xu H (2014) Novel Clinical 7: 105-113. [Epub 2014] P, Boersma YL, Pluckthun A, Gullick WJ, Yarden S S risk loci for rheumatoid arthritis in Han Chinese Li X , Baker-Andresen D , Zhao Q, Marshall V & Y, Santis G, Winn M, Kholodenko BN, Martin-Fer- and congruence with risk variants in Europeans. Kim I, Ferreira L, Tey LS & Wallis G (2013) Integration Bredy TW (2014) Methyl CpG Binding Domain nandez ML, Parker P, Tutt A, Ameer-Beg SM & Ng Arthritis and Rheumatism 66: 1121–1132. of driving simulator and traffic simulation to ana- Ultra-Sequencing: a novel method for identifying lyse behaviour at railway crossings. Proceedings T (2014) The ErbB4 CYT2 variant protects EGFR inter-individual and cell-type-specific variation of the Institution of Mechanical Engineers, Part from ligand-induced degradation to enhance in DNA methylation. Genes, Brain and Behavior F: Journal of Rail and Rapid Transit 227: 427-438. cancer cell motility. Science Signaling 7: ra78. 13: 721–731.

RECOGNITION 76 Publications Publications

Liang V, Ullrich M, Lam H, Chew YL, Banister S, Liu CS & Tian X (2014) A data-driven method to Marioni RE, Batty GD, Hayward C, Kerr SM, Camp- Martin S, Papadopulos A, Tomatis VMS, Sierecki Song X, Zaw T, Kassiou M, Götz J & Nicholas reduce the impact of region size on degree bell A, Hocking LJ, Porteous DJ, Visscher PM & E, Malintan NTS, Gormal RS, Giles N, John- HR (2014) Altered proteostasis in aging and metrics in voxel-wise functional brain networks. Deary IJ (2014) Common genetic variants explain ston WA, Alexandrov K, Gambin Y, Collins BM & heat shock response in C. elegans revealed by Frontiers in Neurology 5: 199. the majority of the correlation between height Meunier FA (2014) Increased polyubiquitination analysis of the global and de novo synthesized Liu T, Im W, Lee S-T, Ban J-J, Chai YJS, Lee M, Mook- and intelligence: the generation Scotland study. and proteasomal degradation of a munc18-1 dis- proteome. Cellular and Molecular Life Sciences Jung I, Chu K & Kim M (2014) Modulation of Behavior Genetics 44: 91-96. ease-linked mutant causes temperature-sensitive 71: 3339-3361. mitochondrial function by stem cell-derived cel- Marioni RE, Davies G, Hayward C, Liewald D, Kerr defect in exocytosis. Cell Reports 9: 206–218. Lieder F, Stephan KE, Daunizeau J, Garrido MI & lular components. Biochemical and Biophysical SM, Campbell A, Luciano M, Smith BH, Pad- Matusica D & Coulson EJ (2014) Local versus Friston KJ (2013) A neurocomputational model of Research Communications 448: 403–408. manabhan S, Hocking LJ, Hastie ND, Wright long-range neurotrophin receptor signalling: the mismatch negativity. PLOS Computational Long H, Liu B, Hou B, Wang C, Kendrick K, Yu C & AF, Porteous DJ, Visscher PM & Deary IJ (2014) endosomes are not just carriers for axonal Biology 9: e1003288. Jiang T (2014) A potential ethnic difference in the Molecular genetic contributions to socioeco- transport. Seminars in Cell & Developmental Ligthart L, Hottenga JJ, Lewis CM, Farmer AE, Craig association between 5-HTTLPR polymorphisms nomic status and intelligence. Intelligence 44: Biology 31: 57–63. IW, Breen G, Willemsen G, Vink JM, Middeldorp and the brain default mode network. Chinese 26-32. Maucort G, Kasula R, Papadopulos A, Nieminen CM, Byrne EM, Heath AC, Madden PA, Pergadia Science Bulletin 59: 1355-1361. Marshall J & Arikawa K (2014) Unconventional TA, Rubinsztein-Dunlop H & Meunier FA (2014) ML, Montgomery GW, Martin NG, Penninx BW, Long H, Liu B, Hou B, Wang C, Li J & Jiang T colour vision. Current Biology 24: R1150-R1154. Mapping organelle motion reveals a vesicular McGuffin P, Boomsma DI & Nyholt DR (2014) (2014) Authors’ response to “Maternal age as a Marshall J & Cheney KL. (2013). Vision and body conveyor belt spatially replenishing secretory Genetic risk score analysis indicates migraine potential explanation of the role of the L allele colouration in marine invertebrates In JS Werner vesicles in stimulated chromaffin cells. PLOS with and without comorbid depression are of the serotonin transporter gene in anxiety and & LM Chalupa (Eds.), The New Visual Neuro- ONE 9: e87242. genetically different disorders. Human Genet- depression in Asians”. Neuroscience Bulletin 30: sciences (pp. 1165-1178). Cambridge, MA: MIT McGrath JJ (2014) The John Cade Fellowship: ics 133: 173-186. 536-537. Press [Book chapter] modifiable risk factors for serious mental illness. Lin MH, Sivakumaran H, Jones A, Li D, Harper C, Low PC, Manzanero S, Mohannak N, Narayana Marshall NJ, Land MF & Cronin TW (2014) Shrimps Australian and New Zealand Journal of Psychiatry Wei T, Jin H, Rustanti L, Meunier FA, Spann K VK, Nguyen TH, Kvaskoff D, Brennan FH, that pay attention: saccadic eye movements in 48: 13-16. & Harrich D (2014) A HIV-1 Tat mutant protein Ruitenberg MJ, Gelderblom M, Magnus T, Kim stomatopod crustaceans. Philosophical Transac- McGrath JJ (2014) A Rosetta stone for epide- disrupts HIV-1 Rev function by targeting the HA, Broughton BR, Sobey CG, Vanhaesebroeck tions of the Royal Society B: Biological Sciences miology: genomic risk profile scores contain DEAD-box RNA helicase DDX1. Retrovirology B, Stow JL, Arumugam TV & Meunier FA (2014) 369: 20130042. clues related to modifiable risk factors. Epide- 11: 121. PI3Kδ inhibition reduces TNF secretion and Martin AKS, Robinson G, Reutens D & Mowry B miology and Psychiatric Sciences doi:10.1017/ Liu B, Zhang X, Hou B, Li J, Qiu C, Qin W, Yu C & neuroinflammation in a mouse cerebral stroke (2014) Cannabis abuse and age at onset in schiz- s2045796014000651 [Epub ahead of print] Jiang T (2014) The impact of MIR137 on dor- model. Nature Communications 5: 3450. ophrenia patients with large, rare copy number McGrath JJ, Miettunen J, Jaaskelainen E & Dark F solateral prefrontal-hippocampal functional Lu J, Li T, He RQ, Bartlett PF & Götz J (2014) Visu- variants. Schizophrenia Research 155: 21–25. (2014) The onset and offset of psychosis—and connectivity in healthy subjects. Neuropsy- alizing the microtubule-associated protein tau Martin AKS, Robinson G, Reutens D & Mowry B what happens in between. Psychological Med- chopharmacology 39: 2153–2160. in the nucleus. Science China Life Sciences 57: (2014) Cognitive and structural neuroimaging icine 44: 2705-2711. S Liu C , Tian X, Liu H, Mo Y, Bai F, Zhao X, Ma Y 422-431. characteristics of schizophrenia patients with McGrath JJ, Petersen L, Agerbo E, Mors O, & Wang J (2015) Rhesus monkey brain devel- Mantovani S, Gordon R, Macmaw JK, Plfluger CMM, large, rare copy number deletions. Psychiatry Mortensen PB & Pedersen CB (2014) A com- opment during late infancy and the effect of Henderson RD, Noakes PG, McCombe PA & Research: Neuroimaging 224: 311-318. prehensive assessment of parental age and phencyclidine: a longitudinal MRI and DTI study. Woodruff TM (2014) Elevation of the terminal S, Robinson G, Reutens D & psychiatric disorders. JAMA Psychiatry 71: NeuroImage 107: 65-75. [Epub 2014] Martin AK Mowry B complement activation products C5a and C5b-9 (2014) Copy number deletion burden is associ- 301-309. in ALS patient blood. Journal of Neuroimmunol- ated with cognitive, structural, and resting-state McGrath JJ, Wray NR, Pedersen CB, Mortensen ogy 276: 213-218. network differences in patients with schizophre- PB, Greve AN & Petersen L (2014) The association nia. Behavioural Brain Research 272: 324–334. between family history of mental disorders and general cognitive ability. Translational Psychiatry 4: e412.

77 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Publications

McKenzie M, Henders AK, Caracella A, Wray NR & Mohammad MG, Tsai VWW, Ruitenberg MJ, Has- Newman DP, Cummins TDR, Tong JH, Johnson BP, O’Leary CJ, Bradford D, Chen M, White A, Black- Powell JE (2014) Overlap of expression Quan- sanpour M, Li H, Hart PH, Breit SN, Sawchenko Pickering H, Fanning P, Wagner J, Goodrich JTT, more DG & Cooper HM (2014) The netrin/RGM titative Trait Loci (eQTL) in human brain and PE & Brown DA (2014) Immune cell traﬃcking Hawi Z, Chambers CD & Bellgrove MA (2014) receptor, neogenin, controls adult neurogenesis blood. BMC Medical Genomics 7: 31. from the brain maintains CNS immune tolerance. Dopamine transporter genotype is associated by promoting neuroblast migration and cell cycle McLean D, Thara R, John S, Barrett R, Loa P, Journal of Clinical Investigation 124: 1228-1241. with a lateralized resistance to distraction during exit. Stem Cells doi:10.1002/stem.1861. [Epub McGrath J & Mowry B (2014) DSM-IV “criterion Moore RJDS, Taylor GJS, Paulk AC, Pearson T, van attention selection. Journal of Neuroscience 34: ahead of print] A” schizophrenia symptoms across ethnically Swinderen B & Srinivasan MV (2014) FicTrac: 15743-15750. Ortega FJ, Vukovic J, Rodríguez MJ & Bartlett

different populations: evidence for differing a visual method for tracking spherical motion Newport C, Wallis G & Siebeck UE (2014) Concept PF (2014) Blockade of microglial KAPT-channel psychotic symptom content or structural organ- and generating fictive animal paths. Journal of learning and the use of three common psycho- abrogates suppression of inflammatory-me- ization? Culture, Medicine, and Psychiatry 38: Neuroscience Methods 225: 106–119. physical paradigms in the archerfish (Toxotes diated inhibition of neural precursor cells. Glia 408–426. Munday PL, Watson S-A, Chung W-SS, Marshall chatareus). Frontiers in Neural Circuits 8: 39. 62: 247–258. McRae AF, Powell JE, Henders AK, Bowdler L, NJ & Nilsson GE (2014) Response to ‘The impor- Nguyen HS, Dayan P & Goodhill GJ (2014) The Painter DRS, Dux PE, Travis SL & Mattingley

Hemani G, Shah S, Painter JN, Martin NG, Viss- tance of accurate CO2 dosing and measurement influence of receptor positioning on chemotac- JB (2014) Neural responses to target features cher PM & Montgomery GW (2014) Contribution in ocean acidification studies’. Journal of Exper- tic information. Journal of Theoretical Biology outside a search array are enhanced during con- of genetic variation to transgenerational inher- imental Biology 217: 1828-1829. 360: 95–101. junction but not unique-feature search. Journal itance of DNA methylation. Genome Biology Najman JM, Alati R, Bor W, Clavarino A, Mamun A, Nguyen HS, Dayan P & Goodhill GJ (2015) How of Neuroscience 34: 3390-3401. 15: R73. McGrath JJ, McIntyre D, O’Callaghan M, Scott J, receptor diffusion influences gradient sens- Partridge JC, Douglas RH, Marshall NJ, Chung Meurk C, Hall W, Carter A & Chenery H (2014) Shuttlewood G, Williams GM & Wray N (2014) ing. Journal of the Royal Society: Interface 12: W-SS, Jordan TM & Wagner H-J (2014) Reflecting Collecting real-time data from substance users Cohort profile update: the Mater-University of 20141097. [Epub 2014] optics in the diverticular eye of a deep-sea barrel- raises unique legal and ethical issues: reply to Queensland Study of Pregnancy (MUSP). Inter- Nguyen TH, Qiu X, Sun JY & Meunier FA (2014) eye fish (Rhynchohyalus natalensis). Proceedings Kuntsche & Labhart. Addiction 109: 1760. national Journal of Epidemiology doi: 10.1093/ Bulk endocytosis at neuronal synapses. Science of the Royal Society B: Biological Sciences 281: Miao J, Lu J, Zhang Z, Tong Z & He RQ (2013) The ije/dyu234 [Epub ahead of print] China Life Sciences 57: 378-383. 20133223. S effects of formaldehyde on cell cycle is in a Nandam LS, Hester R & Bellgrove MA (2014) Disso- Nguyen VTS, Breakspear M & Cunnington R Paulk AC, Stacey JA, Pearson TWJ, Taylor GJ , S concentration-dependent manner. Progress in ciable and common effects of methylphenidate, (2014) Reciprocal interactions of the SMA and Moore RJD , Srinivasan MV & van Swinderen Biochemistry and Biophysics 40: 641-651. atomoxetine and citalopram on response inhi- cingulate cortex sustain premovement activity B (2014) Selective attention in the honeybee Mills NTS, Wright MJ, Henders AK, Eyles DW, bition neural networks. Neuropsychologia 56: for voluntary actions. Journal of Neuroscience optic lobes precedes behavioral choices. Pro- Baune BT, McGrath JJ, Byrne EM, Hansell NK, 263-270. 34: 16397-16407. ceedings of the National Academy of Sciences of the USA 111: 5006–5011. Birosova E, Scott JG, Martin NG, Montgomery Naughtin CK, Mattingley JB & Dux PE (2014) Dis- Nisbet RM, Polanco JC, Ittner LM & Götz J S GW, Wray NR & Vinkhuyzen AA (2014) Her- tributed and overlapping neural substrates for (2014) Tau aggregation and its interplay with Peak JN, Turner KM & Burne THJ (2015) The itability of transforming growth factor-β1 and object individuation and identification in visual amyloid-β. Acta Neuropathologica doi: 10.1007/ effect of developmental vitamin D deficiency tumor necrosis factor-receptor type 1 expression short-term memory. Cerebral Cortex doi:10.1093/ s00401-014-1371-2 [Epub ahead of print] in male and female Sprague-Dawley rats on and vitamin D levels in healthy adolescent twins. cercor/bhu212 [Epub ahead of print] decision-making using a rodent gambling task. Oh G, Wang S-C, Pal M, Chen ZF, Khare T, Tochigi Twin Research and Human Genetics doi: 10.1017/ Physiology & Behavior 138: 319-324. [Epub 2014] Nedbal J, Visitkul V, Ortiz-Zapater E, Weitsman G, M, Ng C, Yang YA, Kwan A, Kaminsky ZA, Mill thg.2014.70 [Epub ahead of print] Chana P, Matthews DR, Ng T & Ameer-Beg SM J, Gunasinghe C, Tackett JL, Gottesman, II, Wil- Pedersen CB, Mors O, Bertelsen A, Waltoft BL, Mo W, Ying Y, Bartlett PF & He RQ (2014) Tran- (2014) Time-domain microfluidic fluorescence lemsen G, de Geus EJC, Vink JM, Slagboom PE, Agerbo E, McGrath JJ, Mortensen PB & Eaton scriptome profile of human neuroblastoma cells lifetime flow cytometry for high-throughput Wray NR, Heath AC, Montgomery GW, Turecki WW (2014) A comprehensive nationwide study in the hypomagnetic field. Science China Life Förster resonance energy transfer screening. G, Martin NG, Boomsma DI, McGuffin P, Kustra of the incidence rate and lifetime risk for treated Sciences 57: 448-461. Cytometry Part A doi: 10.1002/cyto.a.22616 R & Petronis A (2015) DNA modification study mental disorders. JAMA Psychiatry 71: 573-581. [Epub ahead of print] of major depressive disorder: beyond locus- by-locus comparisons. Biological Psychiatry 77: 246-255. [Epub 2014]

RECOGNITION 78 Publications Publications

Perrier J & Cotel F (2015) Serotonergic modula- Rietveld CA, Conley D, Eriksson N, Esko T, Med- Robinson EB, Kirby A, Ruparel K, Yang J, McGrath Saha S, McGrath J & Scott J (2013) Service use for tion of spinal motor control. Current Opinion land SE, Vinkhuyzen AA, Yang J, Boardman JD, L, Anttila V, Neale BM, Merikangas K, Lehner T, mental health problems in people with delu- in Neurobiology 33: 1-7. [Epub 2014] Chabris CF, Dawes CT, Domingue BW, Hinds DA, Sleiman PMA, Daly MJ, Gur R, Gur R & Hako- sional-like experiences: a nationwide population Perry JR et al. [includes Byrne EM] (2014) Par- Johannesson M, Kiefer AK, Laibson D, Magnus- narson H (2014) The genetic architecture of based survey. PLOS ONE 8: e71951. ent-of-origin-specific allelic associations among son PK, Mountain JL, Oskarsson S, Rostapshova pediatric cognitive abilities in the Philadelphia Saha S, Morgan VA, Castle D, Silove D & McGrath JJ 106 genomic loci for age at menarche. Nature O, Teumer A, Tung JY, Visscher PM, Benjamin DJ, Neurodevelopmental Cohort. Molecular Psychia- (2014) Sociodemographic and clinical correlates 514: 92-97. Cesarini D, Koellinger PD & Social Science Genet- try doi:10.1038/mp.2014.65. [Epub ahead of print] of migrant status in adults with psychotic dis- ics Association Consortium (2014) Replicability , , , McLeay R, Smith Robinson MR & Qvarnström A. (2014). Influence orders: data from the Australian Survey of High Piper M Barry G Harvey TJ and robustness of genome-wide-association AG, Harris L, S, Stringer BW, Day BW, of the environment on the genetic architecture Impact Psychosis. Epidemiology and Psychiatric Mason S studies for behavioral traits. Psychological Sci- , Gronostajski RM, Bailey TL, Boyd AW of traits involved in sexual selection within wild Sciences doi:10.1017/S2045796014000535 [Epub Wray NR ence 25: 1975-1986. & Richards LJ (2014) NFIB-mediated repression populations. In J Hunt & DJ Hosken (Eds.), Gen- ahead of print] of the epigenetic factor Ezh2 regulates corti- Rietveld CA, Esko T, Davies G, Pers TH, Turley P, otype-by-Environment Interactions and Sexual Saha S, Whiteford H & McGrath J (2014) Modelling cal development. Journal of Neuroscience 34: Benyamin B, Chabris CF, Emilsson V, Johnson Selection (pp. 137-168). Chichester, UK: Wiley the incidence and mortality of psychotic disor- 2921-2930. AD, Lee JJ, de Leeuw C, Marioni RE, Medland Blackwell [Book chapter] ders: data from the second Australian national SE, Miller MB, Rostapshova O, van der Lee SJ, Power JM & Sah P (2014) Dendritic spine heter- Robinson MR, Wray NR & Visscher PM (2014) survey of psychosis. Australian and New Zealand Vinkhuyzen AAE, Amin N, Conley D, Der- ogeneity and calcium dynamics in basolateral Explaining additional genetic variation in com- Journal of Psychiatry 48: 352-359. ringer J, van Duijn CM, Fehrmann R, Franke amygdala principal neurons. Journal of Neuro- plex traits. Trends in Genetics 30: 124-132. , Siegmund B & Wiltschko R (2014) Fol- L, Glaeser EL, Hansell NK, Hayward C, Iacono Schiffner I physiology 112: 1616-1627. Robinson PC, Claushuis TA, Cortes A, Martin TM, lowing the sun: a mathematical analysis of the WG, Ibrahim-Verbaas C, Jaddoe V, Karjalainen Evans DM, Leo P, Mukhopadhyay P, Bradbury tracks of clock-shifted homing pigeons. Journal Power RA, Keller MC, Ripke S, Abdellaoui A, Wray J, Laibson D, Lichtenstein P, Liewald DC, Mag- LA, Cremin K, Harris J, Maksymowych WP, Inman of Experimental Biology 217: 2643-2649. NR, Sullivan PF & Breen G (2014) A recessive nusson PKE, Martin NG, McGue M, McMahon G, RD, Rahman P, Haroon N, Gensler L, , genetic model and runs of homozygosity in Pedersen NL, Pinker S, Porteous DJ, Posthuma Powell JE Schiffner I, Vo HD, Bhagavatula PS & Srinivasan van der Horst-Bruinsma IE, Hewitt AW, Craig major depressive disorder. American Journal D, Rivadeneira F, Smith BH, Starr JM, Tiemeier MV (2014) Minding the gap: in-flight body aware- JE, Lim LL, Wakefield D, McCluskey P, Voigt V, of Medical Genetics Part B: Neuropsychiatric H, Timpson NJ, Trzaskowski M, Uitterlinden AG, ness in birds. Frontiers in Zoology 11: 64. Fleming P, Spondyloarthritis Research Con- Genetics 165: 157-166. Verhulst FC, Ward ME, Wright MJ, Davey Smith & Wiltschko R (2014) Pigeon navigation: sortium of Canada, Australio-Anglo-American Schiffner I , Verweij KJH, Zuhair M, Montgomery G, Deary IJ, Johannesson M, Plomin R, Visscher different routes lead to Frankfurt. PLOS ONE 9: Power RA Spondylitis Consortium, International Genetics GW, Henders AK, Heath AC, Madden PAF, Med- PM, Benjamin DJ, Cesarini D & Koellinger PD e112439. of Ankylosing Spondylitis Consortium, Wellcome land SE, & Martin NG (2014) Genetic (2014) Common genetic variants associated Wray NR Trust Case Control Study, Degli-Esposti M, Poin- Schizophrenia Working Group of the Psychiatric predisposition to schizophrenia associated with with cognitive performance identified using ton JJ, Weisman MH, Wordsworth BP, Reveille Genomic Consortium et al. [includes Gratten increased use of cannabis. Molecular Psychiatry the proxy-phenotype method. Proceedings of JD, Rosenbaum JT & Brown MA (2015) Genetic J, Lee SH, Wray NR, Visscher PM, Mowry BJ] 19: 1201-1204. the National Academy of Sciences of the USA dissection of acute anterior uveitis reveals simi- (2014) Biological insights from 108 schizophre- 111: 13790–13794. Ratnu VSS, Wei W & Bredy TW (2014) Activa- larities and differences in associations observed nia-associated genetic loci. Nature 511: 421-427. tion-induced cytidine deaminase regulates Roberts NW, How MJ, Porter ML, Temple SE, with ankylosing spondylitis. Arthritis & Rheu- Schmidt ERE, Brignani S, Adolfs Y, Lemstra S, Dem- Caldwell RL, Powell SB, Gruev V, activity-dependent BDNF expression in post-mi- Marshall NJ matology 67: 140-151. [Epub 2014] mers J, Vidaki M, Donahoo A-LSS, Lilleväli K, totic cortical neurons. European Journal of & Cronin TW (2014) Animal polarization imaging Robinson PC & Dalbeth N (2014) Advances in phar- Vasar E, Richards LJ, Karagogeos D, Kolk SM Neuroscience 40: 3032-3039. and implications for optical processing. Proceed- macotherapy for the treatment of gout. Expert & Pasterkamp RJ (2014) Subdomain-mediated ings of the IEEE 102: 1427-1434. Opinion on Pharmacotherapy 16: 4. axon-axon signaling and chemoattraction Robinson AKS, Reinhard J & Mattingley JB (2014) cooperate to regulate afferent innervation of Rosa MJ, Portugal L, Hahn T, Fallgatter AJ, Garrido Olfaction modulates early neural responses to the lateral habenula. Neuron 83: 372-387. , Shawe-Taylor J & Mourao-Miranda J (2015) matching visual objects. Journal of Cognitive MI Sparse network-based models for patient classi- Neuroscience doi:10.1162/jocn_a_00732 [Epub fication using fMRI. NeuroImage 105: 493–506. ahead of print] [Epub 2014]

79 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Publications

Schuyler QA, Wilcox C, Townsend K, Hardesty BD Srinivasan MV, Moore RJDS, Thurrowgood S, Sun F, Wang Y, Zhou Y, van Swinderen B, Gong Z Taylor AE, Fluharty ME, Bjørngaard JH, Gabri- & Marshall NJ (2014) Mistaken identity? Visual Soccol D, Bland D & Knight M. (2013). Vision & Liu L (2014) Identification of neurons responsi- elsen ME, Skorpen F, Marioni RE, Campbell A, similarities of marine debris to natural prey items and navigation in insects, and applications to ble for feeding behavior in the Drosophila brain. Engmann J, Mirza SS, Loukola A, Laatikainen of sea turtles. BMC Ecology 14: 14. aircraft guidance. In JS Werner & LM Chalupa Science China Life Sciences 57: 391-402. T, Partonen T, Kaakinen M, Ducci F, Cavadino Sester DP, Thygesen SJ, Sagulenko V, Vajjhala (Eds.), The New Visual Neurosciences (pp. 1219- Tada H, Won HH, Melander O, Yang J, Peloso GM & A, Husemoen LL, Ahluwalia TS, Jacobsen RK, PR, Cridland JA, Vitak N, Chen KW, Osborne 1227). Cambridge, MA: MIT Press [Book chapter] Kathiresan S (2014) Multiple associated variants Skaaby T, Ebstrup JF, Mortensen EL, Minica CC, GW, Schroder K & Stacey KJ (2015) A novel flow Srivatsa S, Parthasarathy S, Britanova O, Bormuth increase the heritability explained for plasma Vink JM, Willemsen G, Marques-Vidal P, Dale cytometric method to assess inflammasome I, Donahoo A-LS, Ackerman SL, Richards LJ & lipids and coronary artery disease. Circulation: CE, Amuzu A, Lennon LT, Lahti J, Palotie A, Rai- formation. Journal of Immunology 194: 455-462. Tarabykin V (2014) Unc5C and DCC act down- Cardiovascular Genetics 7: 583-587. kkonen K, Wong A, Paternoster L, Wong AP-Y, Horwood LJ, Murphy M, Johnstone EC, Kennedy [Epub 2014] stream of Ctip2 and Satb2 and contribute to S & (2014) Phosphorylation Talwar S Lynch JW MA, Pausova Z, Paus T, Ben-Shlomo Y, Nohr EA, Shah S, Mackinnon A, Galletly C, Carr V, corpus callosum formation. Nature Communi- mediated structural and functional changes in McGrath Kuh D, Kivimaki M, Eriksson JG, Morris RW, Casas , Stain HJ, Castle D, Harvey C, Sweeney S & cations 5: 3708. pentameric ligand-gated ion channels: implica- JJ JP, Preisig M, Boomsma DI, Linneberg A, Power Morgan VA (2014) Prevalence and impact of tions for drug discovery. International Journal Strobel C, Hunt S, Sullivan R, Sun J & Sah P C, Hyppönen E, Veijola J, Jarvelin M-R, Korhonen childhood abuse in people with a psychotic of Biochemistry and Cell Biology 53: 218–223. (2014) Emotional regulation of pain: the role of T, Tiemeier H, Kumari M, Porteous DJ, Hayward illness. Data from the second Australian national noradrenaline in the amygdala. Science China Tattersall TLS, Stratton PG, Coyne TJ, Cook R, C, Romundstad PR, Smith GD & Munafo MR survey of psychosis. Schizophrenia Research 159: Life Sciences 57: 384–390. Silberstein P, Silburn PA, Windels F & Sah P (2014) Investigating the possible causal associ- 20-26. Strydom R, Thurrowgood S & Srinivasan MV (2014) Imagined gait modulates neuronal net- ation of smoking with depression and anxiety Shah S, McRae AF, Marioni RE, Harris SE, Gibson (2014) Visual odometry: autonomous UAV work dynamics in the human pedunculopontine using Mendelian randomisation meta-analysis: J, Henders AK, Redmond P, Cox SR, Pattie A, navigation using optic flow and stereo. Paper nucleus. Nature Neuroscience 17: 449-454. the CARTA consortium. BMJ Open 4: e006141. Corley J, Murphy L, Martin NG, Montgomery presented at the Australasian Conference on Taylor AE, Morris RW, Fluharty ME, Bjorngaard JH, GW, Starr JM, Wray NR, Deary IJ & Visscher Robotics and Automation 2–4 December, Uni- Asvold BO, Gabrielsen ME, Campbell A, Marioni PM (2014) Genetic and environmental exposures versity of Melbourne, Australia. R, Kumari M, Hallfors J, Mannisto S, Marques- constrain epigenetic drift over the human life Suárez R, Fenlon LRS, Marek RS, Avitan L, Sah Vidal P, Kaakinen M, Cavadino A, Postmus I, course. Genome Research 24: 1725-1733. P, Goodhill GJ & Richards LJ (2014) Balanced Husemoen LL, Skaaby T, Ahluwalia TS, Treur JL, Soltész F, Suckling J, Lawrence P, Tait R, Ooi C, Bent- interhemispheric cortical activity is required for Willemsen G, Dale C, Wannamethee SG, Lahti ley G, Dodds CM, Miller SR, Wille DR, Byrne correct targeting of the corpus callosum. Neuron J, Palotie A, Raikkonen K, Kisialiou A, McCon- M, McHugh SM, Bellgrove MA, Croft RJ, Lu B, 82: 1289-1298. nachie A, Padmanabhan S, Wong A, Dalgard C, Bullmore ET & Nathan PJ (2014) Identification of Suárez R, Gobius IS & Richards LJ (2014) Evolution Paternoster L, Ben-Shlomo Y, Tyrrell J, Horwood BDNF sensitive electrophysiological markers of and development of interhemispheric connec- J, Fergusson DM, Kennedy MA, Frayling T, Nohr synaptic activity and their structural correlates tions in the vertebrate forebrain. Frontiers in EA, Christiansen L, Ohm Kyvik K, Kuh D, Watt G, in healthy subjects using a genetic approach Human Neuroscience 8: 497. Eriksson J, Whincup PH, Vink JM, Boomsma DI, utilizing the functional BDNF Val66Met poly- Davey Smith G, Lawlor D, Linneberg A, Ford I, Sullivan S, Wills A, Lawlor D, McGrath J & Zammit morphism. PLOS ONE 9: e95558. Jukema JW, Power C, Hypponen E, Jarvelin MR, S (2013) Prenatal vitamin D status and risk of psy- Preisig M, Borodulin K, Kaprio J, Kivimaki M, Srinivasan MV (2014) Going with the flow: a brief chotic experiences at age 18 years-a longitudinal Smith BH, Hayward C, Romundstad PR, Sorensen history of the study of the honeybee’s navi- birth cohort. Schizophrenia Research 148: 87-92. gational ‘odometer’. Journal of Comparative TI, Munafo MR & Sattar N (2014) Stratification by Physiology A 200: 563-573. smoking status reveals an association of CHR- NA5-A3-B4 genotype with body mass index in never smokers. PLOS Genetics 10: e1004799. Sutherland DJ, Pujic Z & Goodhill GJ (2014) Calcium signaling in axon guidance. Trends in Neurosciences 37: 424–432.

RECOGNITION 80 Taylor CJ, He RQ & Bartlett PF (2014) The role Tovey ER, Stelzer-Braid S, Toelle BG, Oliver BG, Vaidya B, Wright A, Shuttleworth J, Donohoe M, Vinkhuyzen AA & Wray NR (2014) Novel of the N-methyl-D-aspartate receptor in the Reddel HK, Willenborg CM, Belessis Y, Garden Warren R, Brooke A, Gericke CA & Ukoumunne directions for G x E analysis in psychiatry. Epi- proliferation of adult hippocampal neural stem FL, Jaffe A, Strachan R, Eyles D, Rawlinson WD & OC (2014) Block & replace regime versus titration demiology and Psychiatric Sciences doi:10.1017/ and precursor cells. Science China Life Sciences Marks GB (2014) Rhinoviruses significantly affect regime of antithyroid drugs for the treatment s2045796014000584 [Epub ahead of print] 57: 403-411. day-to-day respiratory symptoms of children of Graves’ disease: a retrospective observational Visscher PM & Goddard ME (2015) A general unified Tey LS, Zhu S, Ferreira L & Wallis G (2014) Microsim- with asthma. Journal of Allergy and Clinical study. Clinical Endocrinology 81: 610–613. framework to assess the sampling variance of ulation modelling of driver behaviour towards Immunology doi: 10.1016/j.jaci.2014.10.020. [Epub van der Burg NMD, Lavidis N, Claudianos C & heritability estimates using pedigree or mark- alternative warning devices at railway level ahead of print] Reinhard J (2014) A novel assay to evaluate er-based relationships. Genetics 199: 223-232. crossings. Accident Analysis and Prevention Turner KMS & Burne THJ (2014) Comprehen- olfactory modulation of honeybee aggression. [Epub 2014] 71: 177-182. sive behavioural analysis of Long Evans and Apidologie 45: 478-490. Visscher PM, Hemani G, Vinkhuyzen AAE, Chen Thoen HHS, How MJ, Chiou T-HS & Marshall J Sprague-Dawley rats reveals differential effects Van Lange PAM, Vinkhuyzen AAE & Posthuma G-B, Lee SH, Wray NR, Goddard ME & Yang (2014) A different form of color vision in mantis of housing conditions on tests relevant to neu- D (2014) Genetic influences are virtually absent J (2014) Statistical power to detect genetic (co) shrimp. Science 343: 411. ropsychiatric disorders. PLOS ONE 9: e93411. for trust. PLOS ONE 9: e93880. variance of complex traits using SNP data in Thurrowgood S, Moore RJDS, Soccol D, Knight M Ueda P, Rafatnia F, Baarnhielm M, Frobom R, Korzu- van Swinderen B & Kottler B (2014) Explaining unrelated samples. PLOS Genetics 10: e1004269. & Srinivasan MV (2014) A biologically inspired, nowicz G, Lonnerbro R, Hedstrom AK, Eyles D, general anesthesia: a two-step hypothesis linking Waghorn G, Saha S & McGrath JJ (2014) Correlates vision-based guidance system for automatic Olsson T & Alfredsson L (2014) Neonatal vitamin sleep circuits and the synaptic release machinery. of competitive versus noncompetitive employ- landing of a fixed-wing aircraft. Journal of Field D status and risk of multiple sclerosis. Annals of Bioessays 36: 372-381. ment among adults with psychotic disorders. Neurology 76: 338-346. Robotics 31: 699-727. Vanhatalo S, Alnajjar A, Nguyen VTS, Colditz P & Psychiatric Services 65: 476-482. Timpson NJ, Walter K, Min JL, Tachmazidou I, Ulens C, Spurny R, Thompson AJ, Alqazzaz M, Fransson P (2014) Safety of EEG-fMRI record- Walker AK, Soo KY, Sundaramoorthy V, Parakh S, S Malerba G, Shin SY, Chen L, Futema M, Southam Debaveye S, Han L , Price K, Villalgordo JM, ings in newborn infants at 3T: a study using a Ma Y, Farg MA, Wallace RH, Crouch PJ, Turner L, Iotchkova V, Cocca M, Huang J, Memari Y, Tresadern G, Lynch JW & Lummis SC (2014) baby-size phantom. Clinical Neurophysiology BJ, Horne MK & Atkin JD (2013) ALS-associated McCarthy S, Danecek P, Muddyman D, Man- The prokaryote ligand-gated ion channel ELIC 125: 941-946. TDP-43 induces endoplasmic reticulum stress, captured in a pore blocker-bound conformation gino M, Menni C, Perry JRB, Ring SM, Gaye A, Venkataramani S, Van Wyk M, Buldyrev I, which drives cytoplasmic TDP-43 accumula- by the Alzheimer’s disease drug memantine. Sivyer Dedoussis G, Farmaki AE, Burton P, Talmud PJ, S, & Taylor WR (2014) Distinct roles tion and stress granule formation. PLOS ONE Structure 22: 1399-1407. B Vaney DI Gambaro G, Spector TD, Smith GD, Durbin R, for inhibition in spatial and temporal tuning of 8: e81170. Richards JB, Humphries SE, Zeggini E, Soranzo Ullmann JF, Watson C, Janke AL, Kurniawan ND & local edge detectors in the rabbit retina. PLOS Wang C, Zhang Y, Liu B, Long H, Yu C & Jiang N & UK10K Consortium [includes Visscher, PM Reutens DC (2013) A segmentation protocol ONE 9: e88560. T (2014) Dosage effects of BDNF Val66Met & Yang, J] (2014) A rare variant in APOC3 is asso- and MRI atlas of the C57BL/6J mouse neocortex. Vilgis V, Chen J, Silk TJ, & Vance A polymorphism on cortical surface area and ciated with plasma triglyceride and VLDL levels NeuroImage 78: 196-203. Cunnington R (2014) Frontoparietal function in young people functional connectivity. Journal of Neuroscience in Europeans. 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Wang HL, Yang J, Boykin LM, Zhao QY, Li Q, Woodruff TM, Lee JD & Noakes PG (2014) Role for Zhang Y, Fan L, Zhang Y, Wang J, Zhu M, Zhang Y, Wang XW & Liu SS (2013) The characteristics terminal complement activation in amyotrophic Yu C & Jiang T (2014) Connectivity-based par- and expression profiles of the mitochondrial lateral sclerosis disease progression. Proceedings cellation of the human posteromedial cortex. genome for the Mediterranean species of the of the National Academy of Sciences of the USA Cerebral Cortex 24: 719-727. Bemisia tabaci complex. BMC Genomics 14: 401. 111: E3-E4. Zhang YS, Dixon CLS, Keramidas A & Lynch JW Wang H-L, Yang J, Boykin LM, Zhao Q-Y, Wang Wray NR, Lee SH, Mehta D, Vinkhuyzen AA, (2015) Functional reconstitution of glycinergic Y-J, Liu S-S & Wang X-W (2014) Developing Dudbridge F & Middeldorp CM (2014) Research synapses incorporating defined glycine receptor conversed microsatellite markers and their impli- review: polygenic methods and their application subunit combinations. Neuropharmacology 89: cations in evolutionary analysis of the Bemisia to psychiatric traits. Journal of Child Psychology 391-397. [Epub 2014] tabaci complex. Scientific Reports 4: 6351. and Psychiatry 55: 1068–1087. 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Yang J, Zaitlen NA, Goddard ME, Visscher PM & Control Consortium 2, Spencer CC, Groop L, Marshall J, Achilefu S, Lake SP, Raman B Wang X-C, Zhao Q-Y, Ma C-L, Zhang Z-H, Cao Price AL (2014) Advantages and pitfalls in the Morris AD, Colhoun HM, Sham PC, McCarthy & Gruev V (2014) Bioinspired polarization H-L, Kong Y-M, Yue C, Hao X-Y, Chen L, Ma J-Q, application of mixed-model association meth- MI, Palmer CN & Pearson ER (2014) Heritability imaging sensors: from circuits and optics Jin J-Q, Li X & Yang Y-J (2013) Global transcrip- ods. Nature Genetics 46: 100-106. of variation in glycaemic response to metformin: to signal processing algorithms and bio- tome profiles of Camellia sinensis during cold a genome-wide complex trait analysis. Lancet Yang Z, Choupan J, Sepehrand F, Reutens D & medical applications. Proceedings of the acclimation. BMC Genomics 14: 415. Diabetes & Endocrinology 2: 481-487. Crozier S (2013) Tissue classification for PET/MRI IEEE 102: 1450-1469. Wei W-H, Hemani G & Haley CS (2014) Detect- attenuation correction using conditional random Zhou Y, Li S, Dunn J, Li H, Qin W, Zhu M, Rao L-L, ing epistasis in human complex traits. Nature field and image fusion. International Journal of Song M, Yu C & Jiang T (2014) The neural cor- Reviews Genetics 15: 722-733. Machine Learning and Computing 3: 87-92. Zalesky A, Fornito A, Cocchi L, Gollo LL & Break- relates of risk propensity in males and females Witte JS, Visscher PM & Wray NR (2014) The contri- Ye X-D, Su Y-L, Zhao Q-Y, Xia W-Q, Liu S-S & Wang spear M (2014) Time-resolved resting-state brain using resting-state fMRI. Frontiers in Behavioral bution of genetic variants to disease depends on X-W (2014) Transcriptomic analyses reveal the networks. Proceedings of the National Academy Neuroscience 8: 2. the ruler. Nature Reviews Genetics 15: 765-776. adaptive features and biological differences of of Sciences of the USA 111: 10341–10346. Wood AR et al. 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RECOGNITION 82 Grants Grants

We are grateful for the following national and Australian Research Council Belgian Medical Genomics Motor Neurone Disease international competitive grants and fellowships Initiative Research Institute of Australia starting in 2014; GST and yearly increments are Australian Laureate Fellowship not included in the amounts shown. Grants and Marshall J, Revealing the ‘invisible’: new princi- Visscher P, Belgian Medical Genomics Initiative Grant-in-Aid fellowships awarded by The University of Queens- ples of vision in Australian animals, $2,970,898, [awarded to UQ’s Diamantina Institute in 2011; Benyamin B, Visscher P, Wray N, Trans-ethnic land have also been included. QBI researchers 5 years. transferred to QBI in 2014]. and trans-omic statistical analyses to identify are denoted in bold. Centre of Excellence new ALS risk variants, $100,000, 1 year. Egan G (CI), Rosa M (CI), Mattingley J (CI), Rob- Mangelsdorf M, Bartlett P, McCombe P, Hen- Alzheimer’s Australia inson P (CI), Sah P (CI), Stuart G (CI), Ibbotson Brain Foundation derson R, Targeting EphA4 as a treatment for Dementia Research Foundation M (CI), Lowery A (CI), Arabzadeh E (CI), Paxinos Research Gift MND, $100,000, 1 year. G (CI), Martin P (CI), Petrou S (CI), Grunert U Nisbet R, Generation of phosphorylated tau-spe- Postdoctoral Fellowship Wray N, McCombe P, Henderson R, Mangelsdorf (CI), Skafidas E (CI), Garrido M (CI), Breakspear cific intrabodies for the treatment of tauopathies, Nisbet R, Targeting pathogenic tau with phos- M, Zhao Q, Whole exome sequencing of spo- M, (PI), Mitra P (PI), Victor J (PI), Margrie T (PI), $28,050, 1 year. phorylated-tau specific intrabodies, $220,000, Diamond M (PI), Johnson A (PI), Leopold D radic MND, $100,000, 1 year. 2 years. (PI), Movshon J (PI), Markram H (PI), Hill S (PI), Top-Up Scholarship Jirsa V (PI), Tanaka K (PI), ARC Centre of Excel- European Commission 7th National Health and Turnbull M, Neurotrophin regulation of Alzheim- lence for Integrative Brain Function (awarded Framework Programme Medical Research Council er’s disease pathology, $15,000, 2 years. to and administered by Monash University), International Research Staff Exchange NHMRC Project Grant $20,000,000, 7 years. Scheme Bartlett P, Blackmore D, Stimulation of neu- Discovery Early Career Researcher Award Mattingley J, Bellgrove M, O’Connell R, Robert- Australasian Society rogenesis by growth hormone to improve Powell J, Novel approaches for understanding how son I, Four world nodes for brain networks of for Autism Research cognition in an aged animal model of dementia, genetic variation regulates the transcriptome attention and awareness, [collaboration funds], PhD research grant $532,697, 3 years. [awarded to UQ’s Diamantina Institute in 2013; 3 years. Yong An J, PhD research grant, $1,125, 1 year. transferred to QBI in 2014], $364,525, 3 years. Bredy T, Early development, microRNAs, dendrito- Discovery Projects genesis and cognition, $303,447, 3 years. Australian Government Richards L, Early formation of the preplate estab- Fondation Leducq Burne T, Adult vitamin D deficiency and cognitive Department of Education lishes the cerebral cortex, $785,000, 3 years. Career Development Fellowship dysfunction in a mouse model, $405,669, 3 years. Endeavour Research Fellowship Srinivasan M, Perez T, Biologically-inspired Brion, M-J, Determining novel causal risk factors Collins B, Teasdale R, Coulson E, King G, Hong W, Leiter O, 2014 Endeavour fellowship, $26,500, 0.5 year. detection, pursuit and interception of moving for CVD from early life to adulthood: An orig- Endosomal sorting of amyloid precursor protein objects by unmanned aircraft systems, $430,000, inal genome-wide Mendelian randomization in Alzheimer’s disease [awarded to and adminis- Stieb S, 2014 Endeavour fellowship, $26,500, 0.5 year. 3 years. approach [awarded in 2012; transferred to QBI tered by UQ Institute for Molecular Bioscience], Srinivasan M, Perception of pain in simple nerv- in 2014]. $659,354, 4 years. Australian Government ous systems [with Distinguished Outstanding Cooper H, Mowry B, Dissecting the role of RYK in Cooperative Research Centres Research Award], $1,042,837, 3 years. cortical neuron specification and schizophrenia, French Embassy $1,004,152, 3 years. Project Grants van Swinderen B, Dopaminergic mechanisms of visual selective attention in the fly, $365,000, Scientific Mobility Program Cooper H, Understanding the embryonic origins Voingeagu I, Feng J, Claudianos C, Eapen V, Project , Scientific Mobility Program 3 years. Bertran-Gonzalez J of cortical malformations, $800,574, 3 years. 1.019RI Transcriptome analyses of human ASD 2013, $2,500, 1 year. brain tissue as a complementary method to aid Linkage Infrastructure, Equipment and Eyles D, Meyer U, Do the developmental vitamin the identification of ASD susceptibility genes, Facilities D-deficiency and maternal immune activation $50,000, 1 year. Gaus K, Gooding J, Boecking T, Lee L, Whisstock National Computational animal models of schizophrenia have convergent J, Rossjohn J, Hertzog P, Heath W, Godfrey D, Merit Allocation Scheme early pathways? $646,894, 3 years. Hatters D, Quiney H, Abbey B, Braet F, King N, Eyles D, Burne T, The developmental vitamin , National Computational Merit Alloca- Grau G, van Oijen A, Goldys E, Mak J, Meunier Visscher P D-deficiency animal model of schizophrenia: tion Scheme, [value in computing time], 1 year. F, Yap A, Eyre N, Russell S [project administered critical window for intervention and optimal by UNSW], $560,000, 1 year. dose, $353,447, 3 years.

83 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Grants

Hilliard M, Xue D, Axonal fusion to promote nerve NHMRC Research Fellowships NSW Environmental Trust The University of Queensland repair: molecules and mechanisms, $441,174, Lynch J, NHMRC Principal Research Fellowship: 3 years. Inhibitory neurotransmitter receptors as ther- Environmental Education Program Early Career Researcher Grants (on behalf of CoralWatch), Corals at your , Transcriptional profiling of long apeutic targets for chronic pain and anxiety Dean A Anggono V Hilliard M, Noakes P, Understanding the role of doorstep - marine conservation through active non-coding RNAs in synaptic plasticity, $20,000, disorders, $727,610, 5 years. TDP-43 in motor neuron disease, $632,562, 3 learning, 3 years. 1 year. years. Meunier F, NHMRC Senior Research Fellowship: , Human electroencephalographic mark- Vesicular trafficking pathways underpinning Garrido M Lynch J, Capon R, A novel mechanism for therapeu- ers of schizophrenia: towards a neurobiologically neuronal secretion and survival Fellowship B, The Royal Australasian tically modulating neurotransmitter-activated informed diagnosis, $21,000, 1 year. ion channels, $645,558, 3 years. $664,515, 5 years. College of Physicians Foundation Research Excellence Award Visscher P, NHMRC Senior Principal Research Fel- McGrath J, Eyles D, Is developmental vitamin D ARA & Starr Open Fellowship Yang J, Quantifying the overall contribution of lowship [awarded to QIMR in 2010; transferred deficiency associated with autism-related phe- Robinson P, Investigating the relationship between all the DNA variants to motor neuron disease, to QBI in 2014], $816,250, 5 years. notypes: a birth cohort study, $334,596, 4 years. genetic changes in ankylosing spondylitis and $70,000, 1 year. changes in immune cell subsets, $40,000, 2 McRae A, Painter J, Inheritance of DNA methyl- years. Major Equipment and Infrastructure ation state in humans, [awarded to the QIMR National Institutes Goodhill G, Meunier F, Richards L, Cooper H, Berghofer Medical Research Institute in 2012; of Health (USA) Coulson E, van Swinderen B, Two-photon transferred to QBI in 2014], $579,766, 3 years. Exploratory/Developmental Research Stanley Medical microscopy for live and fixed imaging in model Meunier F, Collins B, Uncover how Myosin-6 Grant Award [R21 subcontract] Research Institute organisms and thick tissue, $174,941, 1 year. underpins the Ca2+-dependent recruitment of NHMRC Equipment Grant Visscher P, (Isaac Kohane, Harvard Medical School, Gaughran F, McGrath J, Vitamin D in first episode secretory vesicles to the cortical actin network, , , , Piper, M, , US lead investigator), Analysis of Genome-Wide psychosis - Neuroprotective design (D-FEND), Burne T Bredy T Coulson E Götz J $541,855, 3 years. , Touchscreen-automated cognitive Gene-Environment (G x E) Interactions, $156,125, [administered by King’s College London] US$ Bartlett P testing for mice, $49,150, 1 year. Mowry B, Visscher P, Thara R, Gratten J, Genetic 3 years. 1,443,293, 4 years. analysis of de novo and inherited exome varia- Research Program Project Postdoctoral Research Fellowship tion in schizophrenia, $1,319,165, 3 years. Grant [P01 subcontract] Estrada-Mondragon A, Molecular basis of iver- Richards L, Targeting of callosal axons to duplicate Visscher P, Wray N, (Bruce Weir, University of Stockholm School mectin binding to pentameric ligand-gated ion cortical areas in the contralateral hemisphere, Washington, US lead investigator), Statistical of Economics channels, $318,587, 3 years. and Quantitative Genetics (awarded to UQ’s $580,171, 4 years. Visscher P, Statistical genetic analyses of social UQ-Indonesian Partnership Award Diamantina Institute in 2012; transferred to Benyamin B, UQ Indonesian Partnership Award, Sah P, Lynch J, Function and physiological role and economic outcomes [awarded to UQ’s Dia- QBI in 2014). $4,900, 1 year. of inhibitory circuits in the amygdala, $711,868, mantina Institute; transferred to QBI in 2014], 4 years. Research Project Grant [funding ongoing]. UQ-Queensland Institute of Program [R01 subcontract] Medical Research AID seed grant Sah P, Bartlett P, Neurogenesis in the amygdala Eyles D, McGrath J, (Brian Lee, Drexel University, Meunier F, Harrich D, Use of single particle tracking and hippocampus: a role in learnt fear? $749,192, US lead investigator), Early life vitamin D levels Sylvia and Charles Viertel and super resolution microscopy to uncover key 4 years. and risk of autism spectrum disorders, $110,565 Charitable Foundation molecular steps underpinning viral infection, van Swinderen B, Zhao Q, Byrne E, Discovering 2 years. Senior Medial Research Fellowship $50,000, 1 year. deep sleep genes and determining their roles for Visscher P (Bruce Weir, University of Washington, Yang J, Methods and large-scale genomic analyses preserving cognitive functions, $469,169, 3 years. US lead investigator), Theoretical population to study the genetic basis of neuropsychiatric Visscher P, Montgomery G, CAGE: Consortium for genetics (awarded to UQ’s Diamantina Institute disorders and obesity, $1,225,000, 5 years. the Architecture of Gene Expression [awarded in 2011; transferred to QBI in 2014). to UQ’s Diamantina Institute; transferred to QBI in 2014], $484,191, 3 years.

RECOGNITION 84 Neuroscience Seminars Neuroscience Seminars

Through a weekly seminar program, QBI gives neu- Dr Allen Cheung Dr Anne Eckert Professor Andrew Hill roscientists an opportunity to learn more about the Queensland Brain Institute, Molecular & Cognitive Neuroscience, University of Department of Biochemistry and Molecular latest scientific developments. The series challenges The University of Queensland Basel, Psychiatric University Clinics Basel, Switzerland Biology, The University of Melbourne researchers in their thinking, promotes excellence Tuning the release kinetics New insights into Alzheimer’s Exosomes and their role in through the exchange of ideas and leads to future of neurotransmission disease: mitochondrial dynamics neurodegenerative diseases collaborations. and circadian rhythms Lavina Codd Dr Kate Hoy Professor Vicki Anderson Queensland Brain Institute, Associate Professor Erica Fletcher Monash Alfred Psychiatry Research Centre Critical Care & Neurosciences, The University of Queensland Department of Anatomy and Neuroscience, The emerging field of cognitive Murdoch Children’s Research Institute Neurogenesis and functional recovery in the The University of Melbourne neurotechology: using brain Neurobehavioral plasticity adult mouse brain after hippocampal stroke The role of microglia in regulating stimulation to enhance cognition after early brain insult photoreceptor integrity Dr Brett Collins Dr Zhitao Hu Associate Professor Markus Barth Institute for Molecular Bioscience, Dr Helen Gooch Harvard Medical School, Centre for Advance Imaging, The University of Queensland Queensland Brain Institute, Massachusetts General Hospital, USA The University of Queensland Structural biology of membrane The University of Queensland Tuning the release kinetics MR neuroimaging at 7 Tesla: trafficking in neurodegeneration Using optogenetics to unravel the amygdala of neurotransmission structure and function Dr Wen-Sung Chung Professor Jürgen Götz Shao-Chang Huang Dr J. Bertran-Gonzalez Queensland Brain Institute, Queensland Brain Institute, Queensland Brain Institute, Queensland Brain Institute, The University of Queensland The University of Queensland The University of Queensland The University of Queensland Complex visual adaptions in squid for Tau and amyloid-β in Alzheimer’s Colour vision of Ischnura heterosticta Ageing and the (dis)organisation different environments—comparison disease: from basic mechanisms (Insecta: Odonata): role in sexual selection, of goal-directed behaviour between common reef squid and rare to therapeutic strategies communication and visual plasticity deep-sea squid (the giant squid) Professor Emery Brown Dr Christine Cong Guo Professor Richard Huganir Department of Brain and Cognitive Sciences, Professor Luciano D’Adamio Queensland Institute of Medical Research Howard Hughes Medical Institute, The Johns Massachusetts Institute of Technology, USA Department of Microbiology & Immunology, Functional network breakdown in Hopkins University School of Medicine, USA Deciphering neural information Albert Einstein College of Medicine, USA neuropsychiatric disorders—from Receptors, synapses and memories representations using state- Is the function of APP relevant to rest to naturalistic stimuli space point process models the pathogenesis of dementia? Georg Kerbler Callista Harper Queensland Brain Institute, Associate Professor Dr Mario de Bono Queensland Brain Institute, The University of Queensland Thomas Burne MRC Laboratory of Molecular Biology, The University of Queensland The basal forebrain plays a central Queensland Brain Institute, University of Cambridge, England The regulation of membrane trafficking role during the development The University of Queensland Encoding a global animal state pathways at the presynaptic nerve terminal of Alzheimer’s disease Translational neuroscience; from epidemiology to animal models Dr Anthony Don Associate Professor Neil Harris Dr Vikram Khurana Prince of Wales Clinical School, UCLA Brain Injury Center, Department Massachusetts Institute of Technology, USA Associate Professor University of New South Wales of Neurosurgery, UCLA, USA Capturing Parkinsonism in a dish: from Charles Claudianos Loss of brain lipid homeostasis as Cortical reorganization after experimental genes to yeast to patient iPS cells Queensland Brain Institute, a driving influence in Alzheimer’s TBI: how much can we achieve? The University of Queensland disease pathogenesis Genome to phenome: characterising Professor Joe Lynch Professor Allan Herbison Queensland Brain Institute, autism spectrum disorder Professor John Duncan Centre for Neuroendocrinology, The University of Queensland The University of Cambridge, England University of Otago, New Zealand Glycinergic synapses in the spinal cord: their A core brain system in assembly Regulating neuronal networks with a kiss relevance to chronic pain and its treatment of cognitive episodes

85 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Neuroscience Seminars

Professor Jason Mattingley Associate Professor Jose Polo Associate Professor Dr Danielle Wilde Queensland Brain Institute, Faculty of Medicine, Monash University Jennifer Rodger Sidney Myer Creative Fellow, RMIT University The University of Queensland Dissecting the molecular events during School of Animal Biology, Coupling movement and creative discovery Eye movements and visual stability reprogramming of somatic cells into The University of Western Australia to transform health and learning landscapes induced pluripotent stem cells Low intensity magnetic stimulation of the Dr Linda Miller brain: evidence for reorganisation of neural Rebecca Williams Children’s Medical Research Institute (CMRI) Dr Simmy Poonian circuits and frequency specific effects Queensland Brain Institute, Isolating the bulk endosome Queensland Brain Institute, The University of Queensland from nerve terminals The University of Queensland Professor Bert Sakmann The assessment of diffusion-weighted MRI as The causal inference between goal-directed Nobel Prize Winner (1991), Max Plank a novel method for functional brain imaging Dr John Morris actions and their sensory consequences Institute of Neurobiology, Germany Queensland Brain Institute, 3D reconstruction of cortical networks and Professor Daniel Wolpert The University of Queensland Professor Caroline (Lindy) Rae circuits for decision making in rodents The University of Cambridge, England The neural basis of the partial The University of New South Wales Probabilistic models of sensorimotor reinforcement extinction effect Two orthogonal topics of interest: Dr Vanesa Tomatis control and decision making brain acetate metabolism and new Queensland Brain Institute, Annika Nichols insights from T2* imaging The University of Queensland Professor Naomi Wray IMP - Research Institute of Molecular Role of myosin VI in neuroexocytosis Queensland Brain Institute, Pathology, Vienna, Austria Dr Tobias Rasse The University of Queensland Lethargus-quiescence in C. elegans Hertie-Institute for Clinical Brain Research, Center Professor Li-Huei Tsai Research strategies that embrace is a systemic brain state under for Neurology, University Hospital, Tübingen The Picower Center for Learning and Memory, the complex genetic etiology tight control of arousal circuits Use of Drosophila to address the Massachusetts Institute of Technology, USA of psychiatric disorders pathomechanisms underlying The role of epigenetic-regulated gene Professor Miguel Nicolelis neurodegenerative diseases that are expression in cognitive function and Professor Zhi-Ying Wu Duke University Medical Center, USA associated with defects in synaptic structure neurodegenerative disorders Fujian Medical University, China Beyond brain-machine interfaces and function: increased mitophagy in From genetics to therapy in PKD Parkinson’s disease: curse or cure? Associate Professor Dr Patricio Opazo Bruno van Swinderen Dr Kaylene Young Max Planck Institute for Neurobiology, Germany Dr Judith Reinhard Queensland Brain Institute, Menzies Research Institute Tasmania The synaptic capture of membrane Queensland Brain Institute, The University of Queensland Myelin plasticity in the adult CNS diffusing AMPA Receptors as a substrate The University of Queensland Sleep and wakefulness in Drosophila for memory formation and disease From memories to molecules: how sensory experience shapes the brain Assistant Professor Helen Zhou Professor Peter Visscher Center for Cognititve Neuroscience, Duke- Dr Michael Piper Queensland Brain Institute, NUS Graduate Medical School, Singapore School of Biomedical Sciences and Queensland Dr Amanda Robinson The University of Queensland Multimodal brain connectome: applications Brain Institute, The University of Queensland Queensland Brain Institute, Genome-wide methylation from human in neurodegenerative diseases Nuclear factor one transcription The University of Queensland blood samples: genetics, environmental factors and cortical development Multisensory interactions between exposures and a role in ageing and disease olfaction and vision: the influence of Associate Professor odours on visual perception and attention Dr Irina Voineagu School of Biotechnology and Biomolecular Roger Pocock Sciences, The University of New South Wales Biotech Research and Innovation Centre, The University of Copenhagen, Denmark Transcriptional networks in MicroRNAs, sugars and the nervous system autism spectrum disorders

RECOGNITION 86 Professional Services Professional Services

Victor Anggono Thomas Burne Ross Cunnington John Kelly • NHMRC Grant Review Panel, Assistant Chair • Biological Psychiatry Australia, Secretary • Australasian Cognitive Neuroscience • National Imaging Facility, Board Member • Medical Research Council Project Grant and Committee Member Society, Past-President • NuNerve Pty Ltd, Board Member (United Kingdom), Reviewer • NHMRC Grant Review Panel Member • International Conference on • Wellcome Trust DBT Fellowship (India), Reviewer • Society for Mental Health Research, Cognitive Neuroscience, Chair Joe Lynch Queensland Representative • Australian Course in Advanced Neuroscience Perry Bartlett Darryl Eyles Scientific Program, Advisory Group Member • Brainnetome Center, Institute of Automation, Charles Claudianos • Biological Psychiatry Australia, Vice President • Australian Neuroscience Society, Secretary The Chinese Academy of Sciences, Beijing, • Autism Cooperative Research • NSW Brain Bank Network, Scientific • Glycine Receptor Nomenclature Committee International Advisory Committee Member Centre, Project Theme Leader Review Committee Member of the International Union of Basic • Centre for Brain Research, University of • BioAutism Ltd, Scientific Advisory Board and Clinical Pharmacology, Chair Geofrey Goodhill Auckland, Scientific Advisory Board Member • NHMRC Early Career Fellowship, Panel Member • International Society for • NHMRC Grant Review Panel Member • Garvan Institute of Medical Research, University Neurochemistry Congress, Cairns Helen Cooper of New South Wales, Scientific Appointments Jürgen Götz (2015), Programming Committee • Australian Huntington’s Disease Association, and Promotions Committee Member • Alzheimer Research Forum Member • NHMRC Research Fellowship, Queensland Branch, QBI Representative • Mater Medical Research Institute • NHMRC Grant Review Panel Member Peer Review Panel Member Limited, Board of Directors, Member • Brisbane Chapter of the American Society • Motor Neurone Disease Research Institute of for Neuroscience, Committee Member Massimo Hilliard Justin Marshall Australia, Research Committee Member • NHMRC Assigners Academy • NHMRC Grant Review Panel Member • Australian Coral Reef Society, Past President and Council Member • NHMRC Research Translation Faculty Member Elizabeth Coulson Tianzi Jiang • Great Barrier Reef Research Expeditions • NHMRC Program Grant Review Panel Member • Alzheimer’s Australia Dementia Research • Brainnetome Branch of Chinese Society Advisory Board Member • Science of Learning Research Centre, Foundation Scientific and Medical Panel Member for Anatomical Sciences, President Advisory Board Member • International Society for • Chinese Society for Anatomical Sciences, Jason Mattingley • SpinalCure Australia Director and Neurochemistry Summer School, Standing Member of Board of Directors • Academy of Social Sciences in Australia, Scientific Board Chairman Organising Committee Member • Chinese Society for Cognitive Science, Member Panel D (Psychology, Social Medicine, • NHMRC Assigner’s Academy Member of Board of Directors- Hunan Key Laboratory Education) Committee Member Timothy Bredy of Diagnosis and Therapy of Psychiatry, • Association for Attention and Performance, • Agence Nationale de la Recherche • NHMRC Dementia Research and Translation Scientific Committee Deputy Chair Advisory Council Member (France), Grant Reviewer Priority Setting Project Focus Group Member • Institute of Automation of the Chinese Academy • ARC Centre of Excellence for • European Commission Horizon of Sciences, Scientific Committee Member Cognition and its Disorders, Scientific 2020, Grant Reviewer • Key Laboratory for NeuroInformation Advisory Committee Member • Fonds Nationale de la Recherche of the Ministry of Education of China, • Australian Academy of Science National (Luxembourg), Grant Reviewer Scientific Committee Member Committee for Brain and Mind Member • KAUST competitive research • Tianjing Key Laboratory of Brain Functional • NHMRC Assigners Academy grant program, Reviewer Imaging, Scientific Committee Chair • Sylvia & Charles Viertel Charitable Foundation, Grant Reviewer

87 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Professional Services

John McGrath Linda Richards Peter Visscher • Australian Schizophrenia Research • Agence Nationale de la Recherche • Centre for Cognitive Ageing and Bank, Access Committee Member (France), Grant Reviewer Australian Brain Cognitive Epidemiology (University • ANZ Trustees Queensland Medical Bee Challenge, National Coordinator of Edinburgh), Member Program Review Committee • Australian Disorders of the Corpus • New Zealand Statistical Genetics Network • NHMRC Australian Health Ethics Callosum (AusDOCC), Scientific Advisor Scientific Advisory Board, Member Committee Member • Medical Research Council, UK, Grant Reviewer • Social Science Genetics Association • NHMRC Research Committee Member • Royal Society of New Zealand, Centres Consortium, Advisory Board of Research Excellence (CoRE) panel • NHMRC Grant Review Panel Member Jana Vukovic • Vice-President, International Brain Bee • Orygen Youth Health Research Centre, • Australian Academy of Science Theo Research Committee Member Pankaj Sah Murphy High Flyers Think Tank • Research Australia Board Member • Australian Course in Advanced Neuroscience, Stephen Williams • Schizophrenia International Research Course Management Committee Member Society, Board Member • NHMRC Grant Review Panel Member • Multiple Sclerosis Australia Grant • Schizophrenia Research Forum, Review Panel Member Naomi Wray Advisory Board Member • NHMRC Assigners Academy Member • Anorexia Nervosa Genetics Initiative, Frederic Meunier • NHMRC Career Development Scientific Advisory Board • National Association of Research Fellows Fellowship Panel Member • Australian Neurogenetics Meeting, Convener Queensland Representative • Science of Learning Research Centre, • Consortium for Lithium Genetics, Advisor Executive Committee Member • World Congress Psychiatric Genetics, Bryan Mowry Copenhagen, Scientific Committee Member • Australian Schizophrenia Research Bank: Science Mandyam Srinivasan Committee Member, Genetics Committee • Australasian Conference on Robotics and Huji Xu Member and Access Committee Member Automation (ACRA), Program Committee • Chinese Rheumatology Association, • Royal Australian and New Zealand College of • Australian Academy of Science Shanghai Branch, President Psychiatrists, Member, Committee for Research CMSE Fellowship Committee • Chinese Rheumatology • Cold Spring Harbor Asia Conferences, Association, Vice President Michael Piper Scientific Advisory Board • Chinese Clinical Immunology, • Australasian Neuroscience Society, • National ICT Australia Ltd, Research Association Standing Member Queensland Representative Evaluation Committee • National Natural Science Foundation of China, • NHMRC Assigners Academy, Member • Prime Minister’s Science Prize Committee Program Review Committee Member Judith Reinhard Jian Yang • Australian Association of von Humboldt • NHMRC Grant Review Panel Member Fellows, Queensland Representative • Australasian Association for Chemosensory Science Council Member

RECOGNITION 88 Editorial Boards UQ Appointments

Perry Bartlett Jürgen Götz John McGrath Pankaj Sah • Acta Physiologica Sinica, Editorial Board • Alzheimer’s Research and Therapy, • Acta Psychiatrica Scandinavica, Editorial Board • BioMedCentral Physiology, Editorial Board • Developmental Neurobiology, Editorial Board Editorial Board • Australian and New Zealand Journal • Channels, Editorial Board • Developmental Neuroscience, Editorial Board • Frontiers in Neuroscience, Review Editor of Psychiatry, Editorial Board • Hippocampus, Editorial Board • Frontiers in Neurogenesis, Associate Editor • Journal of Alzheimer’s Disease, Associate Editor • BioMedCentral Psychiatry, Editorial Board • Journal of Neurophysiology, Associate Editor • Clinical Schizophrenia and Related Psychoses, • International Journal of Developmental • PLOS ONE, Academic Editor • Journal of Neuroscience, Editorial Board Editorial Board Neuroscience, International Editorial Board • Neural Plasticity, Editorial Board Tianzi Jiang • Epidemiology and Psychiatric Science, • Neural Development, Editorial Board • Chinese Journal of Medical Imaging Technology, Associate Editor • The Open Neuroscience Journal, • Neurosignals, Editorial Board Deputy Editor-in-Chief • Frontiers in Molecular Psychiatry, Editorial Board Editorial Advisory Board • Stem Cell Research, Editorial Board • Cognitive Neurodynamics, Editorial Board • Revista Brasileira de Psiquiatria, Associação Mandyam Srinivasan • Yonsei Medical Journal, Editorial Board • Frontiers in Brain Imaging Methods, Brasileira de Psiquiatris, Editorial Board • Journal of Comparative Physiology A, Review Editor • Schizophrenia Bulletin, Associate Editor Timothy Bredy Editorial Advisory Board • IEEE Transactions on Medical Imaging, • Frontiers in Biology, Editorial Board • Schizophrenia Research, Editorial Board • PLOS Biology, Editorial Board Associate Editor • Stress, Brain, & Behavior, Editorial Board Thomas Burne • IEEE Transactions on Autonomous Mental • Translational Psychiatry, Editorial Board Bruno van Swinderen • PLOS ONE, Academic Editor Development, Associate Editor • PLOS ONE, Academic Editor • Neuroscience Bulletin, Associate Editor Frederic Meunier • Frontiers, Review Editor Charles Claudianos • Current Neuropharmacology, Editorial Board • PLOS ONE, Academic Editor • Frontiers in Psychiatry, Associate Editor • Journal of Neurochemistry, Handling Editor Peter Visscher • PLOS Genetics, Associate Editor • Psyche, Editorial Board Joe Lynch • PLOS ONE, Academic Editor • Frontiers in Molecular Neuroscience, Helen Cooper • Scientific Reports, Associate Editor Stephen Williams Editorial Board • Frontiers in Cellular Neuroscience, • Growth Factors, Editorial Board Bryan Mowry • International Journal of Biochemistry Associate Editor • Genes, Editorial Board Elizabeth Coulson and Molecular Biology, Editorial Board • Frontiers in Neural Circuits, Associate Editor • PLOS ONE, Academic Editor • Journal of Neurochemistry, Editorial Board • Journal of Biological Chemistry, Editorial Board • Journal of Neuroscience Methods, Editorial Board • PLOS ONE, Editorial Board • Psychiatric Genetics, Editorial Board Justin Marshall Michael Piper Naomi Wray Ross Cunnington • Marine and Freshwater Behaviour • Genetics, Associate Editor and Physiology, Editorial Board • BMC Neuroscience, Editorial Board • Neuropsychologia, Editorial Board • PLOS Genetics, Guest Editorships • PLOS ONE, Academic Editor Judith Reinhard Geofrey Goodhill • Journal of Comparative Physiology A, Huji Xu • Neural Computation, Associate Editor Jason Mattingley Editorial Advisory Board • Frontiers in Immunology, Editorial Board • Brain and Cognition, Editorial Board • Scientific Reports, Editorial Board • PLOS ONE, Academic Editor • Journal of Clinical Physician, Editorial Board • Cognitive Neuroscience, Editorial Board • Chinese Journal of Rheumatology, Linda Richards • Cortex, Associate Editor Editorial Board • Brain Navigator, Editorial Board • Neurocase, Editorial Board • Chinese Journal of Clinical Immunology • Developmental Dynamics, Editorial Board • Neuropsychologia, Editorial Advisory Board and Rheumatology, Associate Editor • Neuroscience Research, Associate Editor • Faculty of 1000, Member • Frontiers in Neuroscience, Editorial Board • International Journal of Brain Science, Editorial Board • Neurosignals, Editorial Board • Scientific Reports, Editorial Board

89 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

UQ Appointments

Perry Bartlett Massimo Hilliard • Academic Board • Library Advisory Committee • Advancement Sub-Committee John Kelly • Anthropology Museum • Biological Resources Steering Committee Management Committee • Professional Staﬀ and Academic • Centre for Advanced Imaging Advisory Board Consulting Committee • Clem Jones Centre for Ageing • Vice-Chancellors Risk and Dementia Research Advisory Board Compliance Committee • Health and Medical Research • UQ Network Steering Committee Advancement Board • University Senior Management Group Marie Mangelsdorf • Anatomical Biosciences Animal Thomas Burne Ethics Committee • Anatomical Biosciences Animal Ethics Committee, Chair Frederic Meunier • Radiation Health and Safety Committee Jake Carroll • Research Computing Centre, high performance Linda Richards computing architecture panel SME • Collaboration and Industry Engagement Fund Central Selection Committee Helen Cooper • Institutional Biosafety Committee Pankaj Sah • Master of Neuroscience Program Coordinator • Research Committee • MPhil in Neuroscience Coordinator Stephen Williams Elizabeth Coulson • University Research • Small Animal MRI Committee Member Higher Degrees Committee Darryl Eyles • Centre for Advanced Imaging Small Animal Imaging Committee, Vice-Chair Jürgen Götz • Animal Users’ Committee

RECOGNITION 90 International Collaborations International Collaborations

Victor Anggono Charles Claudianos Massimo Hilliard Jason Mattingley • Professor Richard L. Huganir, The Johns Hopkins • Professor Giovanni Galizia, University • Dr Paolo Bazzicalupo and Dr Elia • Dr Tristan Bekinschtein, University University School of Medicine, Baltimore, USA of Konstanz, Germany Di Schiavi, Institute of Biosciences of Cambridge, UK • Professor Se-Young Choi, Seoul National • Professor Martin Giurfa, University and Bioresources, Naples, Italy • Professor Mark Greenlee, University University, Seoul, South Korea of Toulouse, France • Professor Hang Lu, Georgia Institute of Regensburg, Germany • Dr Bo-Shiun Chen, Georgia Regents • Professor Charles Schwartz, of Technology, Atlanta, USA • Dr Redmond O’Connell, Trinity University, Augusta, USA Greenwood Genetic Center, USA • Professor Ding Xue, College Dublin, Ireland • Professor Zila Simoes, University University of Colorado, Boulder, USA Perry Bartlett of Sao Paulo, Brazil • Professor Yun Zhang Harvard John McGrath • Professor Rongqiao He, QBI-IBP Joint Laboratory University, Cambridge, USA • Professor Ron Kessler, World Mental Health of Neuroscience and Cognition, with the Helen Cooper Survey, Harvard Medical School, USA Institute of Biophysics, Beijing, China • Dr Cecilia Flores, Douglas Mental Health Tianzi Jiang • Professor Preben Mortensen, Aarhus • Professor Huji Xu, Joint Sino-Australian University Institute, Montreal, Canada • Juelich Research Center, Germany University (Denmark), National Centre Neurogenetics Laboratory with the Second • Dr Yaobo Liu, Institute of Neuroscience, • Stem Cell and Brain Research for Register-based Research Military Medical University, Shanghai, China Soochow University, Suzhou, China Institute, INSERM U846, France • Dr Fiona Gaughran, Institute of • Dr Vidita Vaidya, Tata Institute of Joe Lynch Psychiatry, Kings College London, UK Fundamental Research, Mumbai, India Elizabeth Coulson • Professor Chris Ulens, • Dr Henning Tiemier and Dr Vincent Jaddoe, • Professor Dongyuan Zhao, Fudan • Professor Jakob Hort, and colleagues, Charles Erasmus Medical Centre, Netherlands University, Prague, Czech Republic Catholic University, Belgium University, Shanghai, China • Professor Sarah Lummis, • Dr Christina Dalman and Dr Renee • Professor Anders Nykjaer, and colleagues, Gardiner, Karolinska Institute Sweden Timothy Bredy Aarhus University, Aarhus, Denmark Cambridge University, UK • Dr Brian Lee, Drexel Univeresity, USA • Nicolas Singewald, University • Professor Andrew Jenkins, of Innsbruck, Austria Ross Cunnington University of Alabama, USA • Dr Debbie Lawlor, Bristol University, UK • Tod Kippin, University of California • Professor Christian Windischberger, • Professor Neil Harrison, Medical University of Vienna, Austria Columbia University, USA Frederic Meunier Santa Barbara, USA • Associate Professor Thiruma Arumugam, • Professor Stefan Schweinberger, Friedrich • Professor Mark Rees, University of Swansea, UK • Yi Zhang, Harvard University, USA National University of Singapore, Singapore Schiller University of Jena, Germany • Dr Stephan Pless, Danish School • Haruhiko Bito, University of Tokyo, Japan • Professor Bazbek Davletov, of Pharmacy, Denmark • Carl Stevenson, University of Nottingham, UK Darryl Eyles The University of Sheﬃeld, UK • Arvind Kumar, CSIR-CCMB, Hyderabad, India • Karolinska, Sweden Justin Marshall • Professor Tim Magnus, University • Boyer Winters, University of Guelph, Canada • Drexel University, USA • Professor Tom Cronin, University of Maryland Medical Center Hamburg-Eppendorf, • National Institutes of Health, USA Baltimore County, USA Hamburg, Germany Thomas Burne • U Meyer, ETH Zurich, Switzerland • Associate Professor Viktor Gruev, University of • Professor JianYuan Sun, Institute of Biophysics, • Dr Jared Young, University of Washington, USA Chinese Academy of Sciences, Beijing, China California San Diego, USA • Assistant Professor Rebecca J. Schmidt, University of California Davis, USA • Professor Sonke Johnsen, Duke University, USA • Professor Bart Vanhaesebroeck, Allen Cheung • Dr Gayle C. Windham, Division of Environmental • Professor Nick Strausfeld, University of Arizona, USA University College London, UK • Professor Karen Carleton, University of Maryland • Matthew Collett, University of Exeter, UK and Occupational Disease Control, USA Bryan Mowry College Park, USA • Thomas Collett, Alex Dewar, Paul Graham, • Schizophrenia Research Geofrey Goodhill • Assistant Professor Nick Roberts, University of Andrew Phillippides, University of Sussex, UK Foundation, Chennai, India • University of Cardiﬀ, UK Bristol, UK • Michael Mangan, Barbara Webb, Antoine • Institute of Mental Health, The Sixth • University College London, UK • Professor Ron Douglas, City University London, UK Wystrach, University of Edinburgh, Scotland Hospital, Peking University, Beijing, China • Sir David Attenborough, Atlantic Productions, UK • Wolfgang Stürzl, Germany • Psychiatric Genomics Consortium Aerospace Center, Germany • Professor Eric Warrant, University of Lund, Sweden • Fred Dyer, Michigan State University, USA • Professor Walter Salzburger, University of Basel, Switzerland • Dr Tsr-Huei Chiou, National Cheng Kung University, Taiwan 91 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

International Collaborations

Michael Piper Mandyam Srinivasan Naomi Wray Jian Yang • Francois Guillemot, MRC National • Dr Thomas Labhart, Institute for Molecular and • Professor Patrick Sullivan, Psychiatric • Professor Timothy Frayling, Genetic Institute for Medical Research, UK Life Sciences, University of Zurich, Switzerland Genomics Consortium for Major Depressive Investigation of Anthropometric Traits (GIANT) • Matthew Scott, Stanford, USA • Dr Marie Dacke, Department of Biology, Disorder, University of North Carolina, Consortium, University of Exeter, UK • Richard Gronostajski, SUNY Buffalo, USA University of Lund, Sweden USA & Karolinska Institute, Sweden • Associate Professor Alkes Price, Mixed • Christine Jasoni, University of • Dr Partha Bhagavatula, Department • Professor Mick O’Donovan, Psychiatric Genomics linear model based association Otago, New Zealand of Organismic and Evolutionary Consortium for Schizophrenia, Cardiff, Wales analysis, Harvard University, USA Biology, Harvard University, USA • Dr Stephan Ripke, Psychiatric Genomics • Professor Daniel Benjamin, Social Judith Reinhard Consortium for Statistical Analysis, Sciences Genetic Association • Professor Giovanni Galizia, University Bruno van Swinderen Harvard & Berlin, USA & Germany Consortium, Cornell University, USA of Konstanz, Germany • Paul Shaw, Washington University • Professor Ken Kendler, Psychiatric Genomics • Professor Zibing Jin, Genetics of myopia and eye • Professor Martin Giurfa, University School of Medicine, USA Consortium Cross Disorder Group, Virginia diseases, Wenzhou Medical University, China of Toulouse, France • Li Liu, Institute of Biophysics, Beijing, China Commonwealth University, USA • Assistant Professor Noah Zaitlen, Genetic • Professor Thomas Schulze, difference between populations, University Linda Richards Peter Visscher International Consortium for Lithium of California San Francisco, USA • Professor Elliott Sherr, University of • Professor Mick O’Donovan, Psychiatric Genomics Genetics, Gottingen, Germany California San Francisco, USA Consortium for Schizophrenia, Cardiff, Wales • Professor Jack Hettema, International • Professor James Barkovich, University • Dr Stephan Ripke, Psychiatric Genomics Consortium for Genetics of Anxiety Disorders, of California San Francisco, USA Consortium for Statistical Analysis, Virginia Commonwealth University, USA • Professor John Rubenstein, University Harvard & Berlin, USA & Germany • Professor Nelson Elliott, Genetics of Opium of California San Francisco, USA • Professor Ian Deary, The Lothian Addiction, Washington University St Louis, USA • Professor William Dobyns, University Birth Cohort and cognitive ageing, • Dr Lea Davies, Genetics of Tourette’s Syndrome of Washington, Seattle, USA University of Edinburgh, Scotland and OCD, University of Chicago, USA • Professor Richard Gronostajaki, State • Professor John Witte, Genetic • Professor Christina Hultmann, Genetics of University of New York, Buffalo, USA Epidemiology methods, University of California San Francisco, USA schizophrenia in Sweden, Karolinska Institute • Professor Susumu Mori, Johns • Professor Soumya Raychaudhuri, Genetic Hopkins University, USA • Professor Phillip Koellinger Social Sciences Genetic Association Consortium, relationship between rheumatoid arthritis • Professor Mu-ming Poo, Institute of University of Amsterdam, Netherlands and schizophrenia, Harvard, USA Neuroscience, Shanghai, China • Professor Joel Hirschhorn - Genetic • Professor Yuki Okada, Genetic • Professor Zhiqi Xiong, Institute Investigation of Anthropometric Traits relationship between rheumatoid of Neuroscience, Shanghai, China (GIANT) Consortium, Harvard, USA arthritis and schizophrenia, Japan • Professor Alessandra Pierani, • Assistant Professor Matt Keller, • Professor Ian Deary, The epigenome INSERM, Paris, France Genetics of mental health disorders, of the Lothian Birth Cohort, University • Professor Jeroen Pasterkamp, University University of Colorado, USA of Edinburgh, Scotland Medical Center Utrecht, Netherlands • Professor Bruce Weir, Quantitative and statistical • iPSYCH consortium, Denmark • Professor Victor Tarabykin, Institute of Cell genetics, University of Washington, USA • Professor John Witte, Genetic Biology and Neurobiology, Germany • Professor Bill Hill, Quantitative genetics, Epidemiology methods, University Pankaj Sah University of Edinburgh, Scotland of California San Francisco, USA • Professor Andreas Luthi, Fredrich Meischer • Professor Michel Georges, Complex trait • Professor Elisabeth Binder, Epigenetics Research Institute, Switzerland genomics, University of Liege, Belgium of depression, Max Planck Institute of Psychiatry, Munich, Germany Stephen Williams • Dr Jeff Magee, HHMI/Janelia Farm, Ashburn, USA

RECOGNITION 92 QBI Executive & Faculty QBI Researchers

Director Faculty Professor Perry Bartlett Dr Victor Anggono Professor Geoﬀrey Goodhill Geoﬀrey Osborne Dr Timothy Bredy Dr Massimo Hilliard Dr Michael Piper Deputy Director (Research) Associate Professor Thomas Burne Professor Tianzi Jiang Dr Judith Reinhard Professor Pankaj Sah (Conjoint Appointment) Professor Joe Lynch Professor Linda Richards Deputy Director (Operations) Dr Allen Cheung Dr Marie Mangelsdorf Professor Pankaj Sah John Kelly Associate Professor Charles Claudianos Professor Justin Marshall Professor Mandyam Srinivasan Associate Professor Helen Cooper Professor Jason Mattingley Associate Professor Bruno van Swinderen Associate Professor Elizabeth Coulson Professor John McGrath Professor Peter Visscher Associate Professor Ross Cunnington (Conjoint Appointment) Professor Stephen Williams Associate Professor Darryl Eyles Professor Frederic Meunier Professor Naomi Wray (Conjoint Appointment) Professor Bryan Mowry Professor Huji Xu Professor Jürgen Götz (Conjoint Appointment) Dr Jian Yang

The University of Queensland Afliates Adjunct Appointments Conjoint Appointments Professor Andrew Boyd Professor Mark Bellgrove Stephanie Bell Professor Matthew Brown Dr Marta Bortoletto Dr Bill Mantzioris Dr Brett Collins Dr Tarrant Cummins Dr Lawrence Sanjay Nandam Dr Hannah Filmer Associate Professor Geoffrey Faulkner Dr Sathish Periyasamy Professor Wayne Hall Dr Daniel Gilbert Dr Sukanta Saha Dr David Kvaskoff Dr Adam Hamlin Emeritus Professors Dr Sean Millard Dr Ziarih Hawi Professor Jack Pettigrew Associate Professor Peter Noakes Dr Robert Hester Professor David Vaney Dr Melody Puckridge Dr Martin How Dr Jeremy Ullmann Dr Sujit John Honorary Professors Associate Professor Paul Dux Dr Jonathan Mann Professor David Adams Professor David Reutens Professor Geoffrey Masters Professor Shaun Collin Dr Marc Ruitenberg Dr Duncan McLean Professor David Gearing Dr Ethan Scott Dr Thomas Moore Professor Christian Gericke Professor Peter Silburn Dr Grant Montgomery Professor Gisela Kaplan Dr Surya Singh Associate Professor Dale Nyholt Professor Ottmar Lipp Dr Hari Subramanian Dr Weichuan Mo Professor Nicholas Martin Professor Walter Thomas Dr Riccardo Marioni Professor Hideyuki Okana Dr Lata Vadlamudi Dr Yajing Sun Professor Tristan Perez Associate Professor Guy Wallis Dr Rangaswamy Thara Professor Brent Reynolds Dr Zhengyi Yang Professor Lesley Rogers Professor Seong-Seng Tan Professor Charles Watson Honorary Researchers Associate Professor Christine Guo Associate Professor Michael Wilson

93 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

QBI Researchers

Postdoctoral Fellows Dr Eleonora Autuori Dr Alexandre Cristino Dr Marc Kamke Dr Ellen Meelkop Dr Amanda Robinson Dr Anna Vinkhuyzen Dr Lilach Avitan Dr Xiaoying Cui Dr Angelo Keramidas Dr Divya Mehta Dr Matthew Robinson Dr Jana Vukovic Dr Corinne Bareham Dr Simon De Croft Dr Benjamin Kottler Gerhard Moser Dr Phillip Robinson Dr Qian Wang Dr Oliver Baumann Dr Argel Estrada Dr Peter Kozulin Dr Ramesh Narayanan Dr Martin Sale Dr Tong (Iris) Wang Dr Jeﬀ Bednark Dr Richard Faville Dr Vanessa Lanoue Dr Brent Neumann Dr Miriam Sanchez Matamales Dr Wei Wei Dr Beben Benyamin Dr Javed Fowdar Dr Aoife Larkin Dr Tam Nguyen Dr Ingo Schiﬀner Dr Jocelyn Widagdo Dr Daniel Blackmore Dr Yakir Gagnon Dr Hong Lee Dr Christopher Nolan Dr Sonia Shah Dr Nicole Wilson Dr Liviu Bodea Dr Marta Garrido Dr Yi-Hsin Lee Dr Conor O’Leary Dr Konstantin Shakhbazov Dr Francois Windels Dr Marie-Jo Brion Dr Rosina Giordano-Santini Dr Chuanzhou Li Dr Kathie Overeem Dr Benjamin Sivyer Dr Qiongyi Zhao Dr Jens Bunt Dr Ilan Gobius Dr Yonghui Li Dr Rebecca Nisbet Dr Peter Stratton Dr Yanqiong Zhou Dr Enda Byrne Dr J Bertran Gonzalez Dr Jing Lu Dr Andreas Papadopulos Dr Cornelia Strobel Dr Zhihong Zhu Dr Guo-Bo Chen Dr Jake Gratten Dr Wei Luan Dr Juan Polanco Dr Rodrigo Suarez Dr Wen-Sung Chung Dr Callista Harper Dr Allen McRae Dr Joseph Powell Dr Robert Sullivan Dr Sean Coakley Dr Robert Hatch Dr Roger Marek Dr Zlatko Pujic Dr Chanel Taylor Dr Luca Cocchi Dr Robbie Islam Dr Sally Martin Dr Lei Qian Dr Vanessa Tomatis Dr Florence Cotel Dr Dhanisha Jhaveri Dr Dusan Matusica Dr Margaretha Ridder Dr Fabrice Turpin

Research Ofcers Research Assistants Christine Dixon Suzanne Alexander Cheryl Filippich Michael Knight Kalpana Patel Dean Soccol Helen Gooch Kathy Asmussen Javed Fowdar Pauline Ko Thomas Pollak Biao Sun Dr Yu Chau Andrea Baker Alan Goldizen Benjamin Lewis Vikram Ratnu Saul Thurrowgood Luke Lloyd-Jones Andrew Bakshi Rachel Gormal Chang Liu Fiona Ritchie Thuy Truong John Morris Dr Arne Brombas Julia Groening David Lloyd Gregory Robinson Hong Diem Vo Samuel Nayler Tim Butler Nivetha Gunasekaran Andrew Martin Elise Rowe Mirela Wagner Marie Camara Justine Haddrill Jessica McFadyen Bree Rumballe Amanda White Yu Chau Amy Heﬀernan Zoie Nolt Petra Sedlak Li Xu Ming-Yu Chen Anjali Henders Abbey Nydam Henry Simila Zong Zhang Nadia Cummins Alexander Holloway Imogen O’Keefe Zala Skrbis Linda Cumner Peter Josh Kelsey Palghat Peter Smart Dr Angela Dean Diana Kleine Tishila Palliyaguru Heather Smith

RECOGNITION 94 QBI Students QBI Professional Staﬀ

Research Higher Degree Students Master of Neuroscience Students Asad Ali Jayani Hewage Natalie Rens Aprianto Dirga Gonzalo Almarza Shao-chang Huang Amanda Robinson Arezoo Fallah Joon Yong An Nicholas Hughes Michelle Sanchez Vega Sheridan Harvey Adekunle Bademosi Sarah Hunt Suzanne Scott Meera Jacobs Samuel Baker Sharifun Islam Aanchal Sharma Apurva Kumar Siân Baker Oscar Jacoby Chase Sherwell Kelly Munro Danay Baker-Andresen Se Eun Jang Ming Soh Joseph Peard Madhusoothanan Bhagavathi Perumal Ravi Kiran Kasula Paola Spadaro Matthew Trewella Brendan Bicknell Georg Kerbler Ashvin Srinivasan Awarded PhD or MPhil Stephanie Biergans Leonie Kirszenblat Reuben Strydom Anna Bode Anna Bode Elizabeth Kita Yajie Sun Wen-Sung Chung Zoran Boskovic Michael Langford Chia-Hsuan Sung Sean Coakley Megan Campbell Natalie Lee Sahil Talwar Christine Dixon Ye Jin Chai Emilia Lefevre Gavin Taylor Helen Gooch Justin Chaplin Gerhard Leinenga Rachel Templin Veronika Halasz Kok Siong Chen Xiang Li Hanne Thoen Callista Harper Wen-Sung Chung Tong Lin Vanesa Tomatis Shao-Chang Huang Sean Coakley Cirong Liu Susan Travis Thai Vinh Nguyen Lavinia Codd Martin Luhrmann Michael Troup David Painter Nadia Cummins Anne Maallo Marion Turnbull Simandeep Poonian Aymeric Denuelle Robert Maier Karly Turner Vikram Ratnu Daina Dickins Andrew Martin Michelle Watts Amanda Robinson Alessandra Donato Aung Aung Kywe Moe Sarah Williams Aanchal Sharma (MPhil) Christine Dixon John Morris Lisa Wittenhagen Vanesa Tomatis Philip Dyer Vinod Narayana Tong Wu Ilvana Dzaﬁc Thai Vinh Nguyen Di Xia Awarded Master of Neuroscience Laura Fenlon Huyen Thanh Nguyen Shanzhi Yan Adekunle Bademosi Lee Fletcher Morgane Nouvian Yuanhao Yang Samuel Fynes-Clinton Helen Gooch David Painter Xianfeng Yang Muthmainah Natalie Groves Loc Duyen Pham Hon Wai Yap Ozlem Yetim Veronika Halasz Genevieve Phillips Oressia Zalucki Anthony Harris Simandeep Poonian Yan Zhang Callista Harper Chikako Ragan Jing Zhao Luke Hearn Vikram Ratnu Xiaoqing Zhou

95 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

QBI Professional Staﬀ

Institute Manager Scientifc Services Manager Information Technology Occupational Health Science of Learning Research Helen Weir Clare Seaman Manager and Safety Centre Chief Operating Ofcer Jake Carroll Ross Dixon Annita Nugent Grants, Ethics and Laboratory Support Publications Manager John Baisden Information Technology Postgraduate Student Clem Jones Centre for Dr Sylvie Pichelin Dr Sophie Billa Chris Fletcher Administration Manager Ageing Dementia Research Dr Dan Blackmore Perry Kollmorgen Grants, Ethics and Publications Janet Voight Centre Manager Judy Bracefield Alex Kowalczyk Debra McMurtrie Postgraduate Student Jo Sutton Irek Porebski Susan Day Tania Brooks Administration Maria Caldeira Michael Simpson Anne Macaulay Senior Research Manager Jane Ellis Geoff Sullivan Rowan Tweedale Human Resources Manager Luke Hammond Samantha Dyson Jill Wardropper Research Legal and Donna Martin Daniel Matthews Human Resources Technical Services Manager Commercialisation Brooke Ellem David Wheeldon Nicholas Nacsa Dr Latha Kancherla Jackie Perren Virginia Nink Technical Services Stephanie Surm Emma Read Janette Zlamal Adam Barry Advancement, Taryn Reseigh Brandon Horne Communications and Executive Ofce Manager Finance Manager John Steptoe Graphics Director Alison van Niekerk Katherine Parsonage Administrative Support Mikaeli Costello Executive Office Earlene Ashton Advancement, Communications Ashley Cooper Finance Analysis and Ilse Buttiens and Graphics Deirdre Wilson Planning Manager Suzanne Campbell Katie Francis Dr Alan Woodruff Anthony McRae Susan Earnshaw Dee McGrath Finance and Store Dr Nick Valmas Anna Brancatini Sinead Eyre Darius Koreis Wade Ebeling Natasha Gagliano Katherine Robbins Chad Lake Rachael Kelly Michael Perren Charmaine Paiva Esmeli Quevedo Baquero Reeza Palamoodu Nazer

RECOGNITION 96 Philanthropy Philanthropy

Researchers at QBI are dedicated to unlocking the mysteries of neurodegenerative diseases and mental health disorders, which currently account for a staggering 45 per cent of the burden of disease in Australia. By improving the understanding of the fundamental mechanisms that regulate brain function, QBI Major Donors Donor Organisations researchers are working to develop new, more effective therapeutic treatments for conditions such The Stafford Fox Medical Research Foundation HopgoodGanim Lawyers as dementia, stroke, motor neuron disease, multiple sclerosis and neurotrauma. Southern Districts Rugby Union Football Club Inc Estate of Dr Clem Jones AO Nicol Foundation QBI relies on both public and private donations to continue its research programs and is therefore The University of Queensland Endowment Fund Pty Ltd Maclean Distributors Pty Ltd grateful for the support and generosity of its benefactors. Robert Brice, Graeme Wood and John Wylie Stage Five P/L ATF Stage Five Trust Siemon Investments Pty Ltd All members of QBI sincerely thank our valued donors for their support in 2014. Hand Heart Pocket Sunshine Coast Turf Club Inc. Board of Benevolence Frazer Family Foundation Pty Ltd John T Reid Charitable Trusts Cooper Reeves Pty Ltd How to support QBI: The Wilgarning Trust Donations Bequests Rohil Pty Ltd Maclean Sales Pty Ltd Robyn Hilton There are many ways in which you can help By leaving a bequest to QBI in your will, you are ANZ Trustees Limited support QBI’s research effort: leaving a lasting legacy that accelerates current Dalio Foundation Alan Tran Medical Pty Ltd research and preserves future projects. Bequests Ozprop Holdings Pty Ltd • Make a donation for a specific research area can include: Index Group of Companies Aero Products Pty Ltd • Purchase scientific equipment The Maclean Family Hunter Hall International Limited • A percentage of an estate Coolphase Pty Ltd • Fund scholarships for talented students G James Australia Pty Ltd • The residuary of an estate (what remains UBS • Provide fellowships for Lewis Saragossi and Pearle Saragossi after all other gifts and costs have been Priority Building early/mid-career researchers deducted) The MND and Me Foundation Limited Alexandra Hills State High School • Sponsor Professorial Chairs Great South East Developments Pty Ltd • A gift of a specific sum of money Frank & Patsy Youngleson • Undertake laboratory dedications Moggill State School • A particular asset, such as property, works • Provide gifts in memoriam of art, shares, or an insurance policy The Helpful Foundation Goodman Foundation Mercedes-Benz Club of the ACT Inc • Fundraise using the community fundraising Jeff & Fran Maclean University of Queensland Union platform Everyday Hero Crommelin Family Foundation Child’s Play Consultancy Services Tim & Elaine Crommelin Colourcraft Ink Under current legislation, gifts to the Queensland Brain Institute are tax deductible. RD Williams Machinery Pty Ltd To discuss how you can support the Institute, please contact us at: Pogliane Investments Pty Ltd Jandet Pty Ltd The Siganto Family AECOM Australia Pty Ltd Queensland Brain Institute Estate First Lawyers Building 79, St Lucia Campus LIB (187) Pty Limited ITF Clarke Family Trust The University of Queensland Shantbell Pty Ltd Brisbane QLD 4072 Liam J Tansey Pty Ltd Telephone: +61 7 3346 6413 The Clem Jones Foundation Facsimile: +61 7 3346 6301 Email: [email protected] Website: www.qbi.uq.edu.au

97 QBI ANNUAL REPORT 2014 Queensland Brain Institute Annual Report 2014

Philanthropy

Individual Donors David Allan Gillian Colasimone Elizabeth Frith Janice Kefford Michelle May Marie O’Neill Craig Stanley Christopher Allan Garry Collins Malcolm Garrett Steve Kempe John McEvoy Michael Palmer Diana Steenberg Susan Andersen Anthony Cooper Elizabeth Garrett Alistair Kennedy Juliann McEvoy Suzanne Parker The Late Henrik Steenberg Ming Anderson Michael Cooper Colleen Gibbons Jennifer Kennedy Marcia McInnes Jaikisan Patel Barry Stevenson Beverley Angus Blake Cornish Barbara Gilmore Gil Kerr Penny McKelvie Graham Paul Maureen Stevenson Timothy Armstrong Tim Cottee Gayle Ginnane Paul King Moya McKenzie Deborah Peard Kevin Stewart Socrates Aronis John Coulson Elizabeth Gordon Wayne King Ian McMahon Stuart Pegg AM Beverley Stewart Anne Bachelard Marion Coulson Daniel Graham Yvonne Kirkegard Mick McManus* Mario Pennisi Charles Sutton Naomi Bailey Jeanette Covacevich AM PSM Noella Grant Stephen Klein Brendan Meagher Chris Perez-Compton Janet Tansey J Bannister Christine Cowell Fran Gray Steve Knight Brendan Meagher Leah Perry David Thompson Dick Barnett Tim Crommelin Bevan Gray-Moffatt Peter Kowaltzke David Merson Robert Phillips Debra Thompson The Late David Barnett G Crosier Lynette Gray-Moffatt Sandra Lacey Larissa Meyer Suzie Phillips Tony Toohey Sam Bassett Mary Cross Kath Grealy B Lanagan J Mickan David Pook Jenny Tsang Pauline Beames Anne Cullinan T Green Peter Landy Cabrina Milne Eva Popper Thelma Turnbull Doreen Bengtson Margaret Curnow Ronald Grice Nikki Langton John Moller Glenda Powell Douglas Turner Alan Bennett William Curnow AM Don Grimley Samantha Langton Johannes Monaghan David Pradella Susan Vail Stuart Blacket Tammy Dahler Ross Grimley Tracey Larkin William Morgan Clemens Pratt Jorgen van Seters Bruce Blaikie Lynette Davis Jean Gustafson Shirley Larsen W Morgan Tina Previtera Hannah Van Niekerk William Boyce Mary Denver Patricia Haggard Joan Lawrence AM Fiorella Morlin Guy Quarterman B Vorbach Paul Boylan John Di Mauro Norman Hall Max Lennox Karl Morris Robyn Rachow Brendan Ward Charles Brabazon QC Maria Di Mauro Eileen Hall L Liiv David Muir John Redman Mary Ware Jennifer Brennan Ross Dickson Robert Hammond Maija Liiv Veronica Muir John Reid AO M Watt Andrew Brice AM Karl Dodd Gerowyn Hanson Anne Little Bevan Muldoon Colin Richardson Catherine Webster Kim Broadfoot Fiona Draney Troy Harry Keith Locke M Muller Ruth Richardson Cameron Wenck Attracta Brownlee Ruth Duncan Alan Hastie Chris Lonergan Stella Muller Shirley Richter Martine Whitton Iain Bruce Janette Edson* Margaret Henderson Michael Lutkins Denis Murphy Charles Riley Dorothea Wilkinson Joan Bryan AO Jon Edwards* Gregory Henricks Richard Lynch Shaughn Murphy Jamse Riley Irene Willett Timothy Butler Julie Elliott Robyn Hilton Mary Lyons* Joan Murphy David Ritchie Clive Williams Tim Butler Mike Elmer Anne Hilton Bob MacDonnell Denis Nave Brent Roberton Dayna Williams Peter Cairns Dale Fandrich Mary Hilton Jim MacDonnell Judith Nedderman Sue Roberton Margaret Williams Ian Cameron Robyn Fandrich Mark Holmes Terriann MacDonnell Audrey Neill Jason Rose Natalie Willson Tracy Campbell Robyn Farrell Adrian Holt Thomas Mackay Judith Nicol Rosie Russell Matthew Wissemann* Daniel Capper Paul Figallo Tracey Hopkins Craig Maclean Judy Nicol Dina Saragossi Graeme Wood AM Con Carides Robert Fitchew Beth Howard Pam Maclean John Nolan Pearle Saragossi Peter Woodward Gary Carter Shaun Flanigan Glenn Howell Jeffrey Maclean Robin Nolan Geoffrey Sattler Janet Wright Esme Charlson Ian Florence Stewart Howson Fran Maclean Caroline O’Brien Graham Schrodter Ewan Wu Vanessa Charlston Sue Foote Lyle Humphreys Hilda Maclean Simon O’Brien Kelly Schweida Louie Wyatt Kay Christensen Roscoe Foreman Leonard Humphreys Hamish Maclean Emma O’Brien Melinda Seccombe John Wylie AM Bob Christiansen David Forgan-Smith Tony Humphrys Marcus Maclean Patricia O’Connor Stuart Sharry Elizabeth Yates Margaret Clarke Alex Foxton Noyce Hurst Daphne Maclean Janet O’Dwyer Glenda Sharry Patsy Youngleson Ron Clarkson Sean Frampton Bill Johnston Ken Madsen The Late Patrick O’Dwyer John Siemon Qiongyi Zhao Valma Clarkson Bruce Frank Neville Kajewski Jo Marjason Ruth O’Hanlon* Ann Skimaines Barbara Cochrane Robert Franklin Rosemary Kajewski Janice Marshall Gaven O’Neill Raymond Soderholm * QBI staff members

Sincere thanks also to our donors who prefer to remain anonymous.

RECOGNITION 98 Editors Photography Design Ashley Cooper Yan Chan Dr Nick Valmas Mikaeli Costello Tim Butler Darius Koreis Dee McGrath Donna Lu Dr Nick Valmas Dr Nick Valmas Alison van Niekerk Dr Alan Woodruﬀ

99 QBI ANNUAL REPORT 2014

Queensland Brain Institute 2014 Annual Report

Queensland Brain Institute Phone: +61 7 3346 6300 Building 79, St Lucia Campus Fax: +61 7 3346 6301 The University of Queensland Email: [email protected] Brisbane QLD Australia 4072 Web: www.qbi.uq.edu.au