Queensland Brain Institute 2015 Annual Report Cover Image: Synaptic junctions by Anita Goldinger A representation of neuronal connectivity within the brain. From the 2015 QBI Art in Neuroscience collection. 113 5 93 79 71 63 55 17 People Recognition Publications Community Mentorship B eerhr ...... QBI researchers Science ofLearningResearch Centre Centre forNeurogenetics andStatisticalGenomics Clem JonesCentre forAgeingResearch Dementia ...... Cunnington ...... Coulson ...... Cooper Chuang Cheung ...... Burne Bredy ...... Bartlett Anggono Learning aboutthebirds aidflight andthebeeshelps The Asia-Pacific Centre forNeuromodulation 7 ...... Alzheimer’s breakthrough ultrasound uses technology QBIDirector's report 2 UQ Vice-ChancellorandPresident's ...... report QBI executive, andaffiliates faculty Fellowships npj ScienceofLearning..... Events QBI alumni Centres andfacilities Research groups Major developments Grants Awards ...... 116 QBI students ...... QBIstudents 116 25 24 20 27 26 23 22 21 81 QBI publications QBIpublications ...... Philanthropy 81 Australian ..75 Brain Bee Challenge 73 28 98 99 95 ..... Postgraduate students 65 ...... 115 ...... 59 Marshall ...... Lynch Jiang ...... Hu ...... Hilliard ...... Götz ...... Goodhill Eyles ...... iko ...... Dickson Neuroscience seminars Conferences Commercial development 9 ...... 57 ...... 58 ...... 11 ...... 117 102 105 103 35 37 36 34 33 32 31 30 29 67 Graduating students ...... Graduating students 67 2Junleioilbad .... editorial Journal boards 82 Acknowledgements QBI professional staff Richards ...... Piper ...... Osborne Nasrallah Mowry ...... Meunier McGrath ...... Mattingley Animal hous Advanced microscopy facility ...... Sah Diving withthestars regenerationNerve mechanism unlocked Professional service UQ appointments .107 International collaborations ...... 41 ...... e andbehavioural suite ...... 110 ...... 119 4 ...... 15 ...... 111 ...... 118 44 43 42 40 39 38 45 46 68 92 ...61 ...... 62 Table of contents van Swinderen Srinivasan Zuryn Zuryn ...... Yang Wright Wray Williams ...... Visscher ...... 13 ...... Queensland Brain Institute ...... Annual Report 2015 Annual Report ...... 47 51 48 54 53 50 49 52 77
Table of contents QBI ANNUAL REPORT 2015 u an t o t ult ea e an or er brain, to strengthening address efforts someof to adding of thehuman of knowledge global Institute (QBI) continueditsexceptional tradition THROUGHOUT2015 THE Queensland Brain all all contribute in their own ways to creating bene carried out by some 500 staff and students, who Institute’sthe is of work tremendousbulk The per cent, almost doublethenationalaverage.per cent, Project Grants, the QBI strike rate was nearly 24 Council Research Medical and Health National For cent. per 17.7 of average national a to Discovery Projects applications. This compared Australian(ARC)for Council Research cent per funding, QBI staff achieved a success rate of 50 In the tough competition for major government in allthree ofERA. editions A flawless record. third consecutive top-rating for our neuroscience, rating highest . possible standard”—the worldabove “well UQ’sratedas neuroscience In 2015 Excellence in Research for Australia (ERA) andgrantsuccess inpublications applications byreaffirmed repeatedly are strengths These gain from strengths theunique ofQBIstaff. will students more that so UQ, at learning and keen to QBI’s deepen to contributions teaching the new Nature Partner Journal Partner Nature new the Learning Research Centre, and Editor-in-Chief of of Science (ARC) Council ResearchAustralian emotional processing. He is also Director of the in the amygdala, an area of the brain involved in is well known for his research into neural circuits Pankaj, who was an inaugural QBI group leader, Professor Perry Bartlett to Professor Pankaj Sah. after a global search, the directorship passed from a hallmark of QBI since its inception, and in 2015, ficial change. As well, sound leadership has been Learning . Under his leadership the Universityis the leadership his Under . npj Science of This is the the is This - . ing budding scientists. In 2015 they welcomed they 2015 In scientists. budding ing inspir of task rewarding the of sight lost never havestudents and staff InstituteImportantly, nese researchers. for Neurosciences, and deepened ties with Chi- Center Munich the with symposium joint third national collaborations. The Institutealsocontinuedto strengthen inter ical device. one involving a therapeutic and the other a med projects, commercialisation prospective two in progress made QBI 2015 in and research, of products beneficial of dissemination the for canalsobecriticalCommercial partnerships keen to join the QBI and conduct priority research. are who researchersearly-career talented port is named after the foundation Director. It will sup being used to seed the Fellowship,Bartlett which is QBI, of and University the of friend long-term and graduate UQ a Gilmartin, Maureen late the possible. It is indeed fitting that a bequest from people to reach higher than might otherwise be and vision of donors continues to empower QBI to QBI since its earliest days, and the generosity integral been have Philanthropies, Atlantic The of Feeney Chuck notably most Philanthropists, philanthropy. and inindustry partners and—increasingly—by collaboratorsof networks by boosted are ers research- our benefits, widespread deliver to However they are not the full story. In the quest impact. positive for prerequisitesare funding, Excellent underpinning research, and significant UQ Vice-Chancellor and President's report and President's Vice-Chancellor UQ For instance it hosted its For instance ithosted its - - - -
Professor Peter Høj endeavours. future your in power all supporters, and ners part collaborators, as well as QBI, the at study ranks,its in people and work who all wish I and such with university a lead to honoured feel I of science’s mostexciting fields. one in frontier the pushing of thrill the by haps They are driven by a hunger to do good, and per ahead. forge encouragementto little need QBI of people the experience my in scientists—but younger motivate helps surely neuroscience ofveterans distinguished alongside Working Achievement Award. Florey Medal and a Research Australia Lifetime including who Perry gained Bartlett, both a CSL many QBI people who received accolades in 2015, thecongratulate to opportunity this take will I Australia—inducted thisyear. in anywhere fellows—from new 21 only of one was Linda Science. of AustralianAcademy the offellow a become Richards, LindaProfessor it was a delight to see the Challenge’s originator, and Challenge, Australian Brain Bee the of final Queensland the for students high-school 140 The University ofQueensland Vice-Chancellor andPresident Queensland Brain Institute Annual Report 2015 Annual Report R EPORT - - S
Reports Professor Pankaj Sah in front of the Queensland Brain Institute building.
QBI ANNUAL REPORT 2015 n t tute e ate to tu n t e n re t e or ear out tan n anot er on re e tto Medicine Journal ofNeuroscience tal Neurobiology on the covers of covers the on appearing in appearing latter the of 21 with papers, peer-reviewed 273 and papers conference 11 chapters, book nine in the past year. In 2015, QBI authors published published work of calibre the by evidenced as QBI’s neuroscientific research is second to none, t e ene t o n e t n n a re ear el ere n ant o er e t at atte t to ible machinethat isthe brain, andin2015has IN MY FIRST , Trends inNeurosciences Nature report asDirector,report I ampleased and twice on the cover of the of cover the on twice and Nature journals. QBI papers featured , . Science Translational , Developmen- - cially in the field of cortical development. cially inthefieldofcortical contribution she is making to neuroscience, espe Both of these positions recognise the significant of the Australasian Neuroscience Society (ANS). Academy of Sciences, and she is President-Elect Richards was elected as a Fellow of the Australian Professor 2015, In (Research).Director Deputy announce Professor Linda Richards as QBI’s new After commencing as Director, I was pleased to received throughout donations theyear. go to more than 440 supporters from whom we must thanks Many grateful.extremely are we which for commitments, in more significantly donations from individuals and businesses, and We received an additional $2.4 million in generous grant funding. competitive in million $28 of total a securing year,successful very a had again QBI porters. to treat Alzheimer’s restore and disease memory non-invasive ultrasound technology can be used Götz’sJürgenProfessor thatlaboratory by ing find breakthrough the including report, annual Several of these discoveries are featured in this business partnerships andour philanthropic sup partnerships business the funding we receive from government grants, None of our research would be possible without are affected by Alzheimer’s disease. to the hundreds of thousands of Australians who hope gives Research,and Dementia Ageing for work being conducted at the Clem Jones Centre worldwide in 2015, is a testament to the fantastic papers research most-discussed the of one as Altmetric by named discovery,was The which - - - . the first batch of content of the of content of batch first the excitedto publish arevery we 2016, makers.In educators,byresearchers attended policy- and Learning Symposium held in April, which was well and a 2015 highlight was the Nature–Science of nationwide, members 100 than more to grown the centremoney to support raiseto is 2016 for goal major a and research, education into inroads significant made has The Science of Learning Research Centre (SLRC) ResearchNHMRC SeniorPrincipal Fellowship. rector Professor Peter Visscher was awarded an Principal Research Fellow in 2015, and her co-di NHMRC topromoted Professor Wrayalso was disease. neuron motorsporadic of causes the understand better to consortium a fund will which Grant, Challenge Bucket Ice Australia Wray successfully secured a $1.05 million MND Naomi Professorco-director Genomics tistical A team led by Centre for Neurogenetics and Sta non-genetic riskfactors forschizophrenia. on focusses research whose psychiatrist a is Health and Medical Sciences. Professor McGrath elected as a Fellow of the Australian Academy of wasMcGrath year. John this Professor nition Many other QBI staff members received recog that 2016 will bring. that 2016 disorders. I look forward to the exciting research ing Parkinson’s disease, epilepsy and post-stroke deep brain stimulation to treat conditions includ of use the spearheaded has APCN the Coyne, fessor Peter Silburn and neurosurgeon Dr Terry to join QBI were finalised. Led by neurologist Pro Asia-Pacific Centre for Neuromodulation (APCN) the enable would that negotiations 2015, In ration between UQ and Nature Publishing Group. Learning journal, which is produced in collabo in produced is which journal, . The SLRC has npj Scienceofnpj ------Many thanks again for your support, Many thanksagainforyour support, asQBI’sappointment secondDirector. my of support their for Lu MaxProfessor dent Vice-Presi Senior and Provost and Høj, Peter Professor President and Vice-Chancellor to In closing, I would also like to extend my thanks neuroscience research. in achievements lifetime significant his ognise Lifetime Achievement Award, both of which rec CSL Florey Medal and the Research Australia Professor Bartlett received both the prestigious 2015 in order,as in also are Congratulations research group. active an of leaderDirector, the as remains he down stepped has Bartlett Professor While 2003. in inception its since QBI in investment and leadership his for Bartlett, Perry Professor Director,QBI’sfounding thank to like would I Director, QueenslandBrain Institute Professor Pankaj Sah QBI Director's report Queensland Brain Institute
Annual Report 2015 Annual Report R EPORT - - S
Reports Major developments QBI ANNUAL REPORT 2015 announcement regarding Alzheimer’s disease. Palaszczuk MP, ahead of a major research research amajor of MP, ahead Palaszczuk Queensland Premier, The Hon Annastacia Annastacia Hon The Premier, Queensland Professor Jürgen Götz welcomes the the welcomes Götz Jürgen Professor
Major developmentsMajor for improving human health, innovation and from bench to bedside, and have implications Here, we celebrate some of the major QBI developments range across the spectrum, QBI continues to conduct world-leading research. understanding of the brain. developments attained by QBI scientists in 2015. Queensland Brain Institute J A M OR Annual Report 2015 Annual Report D V E ELOPMENT S
6 Major developments Study co-author Gerhard Leinenga demonstrates (with a mouse replica), how a hand-held device could be used to Alzheimer’s breakthrough uses ultrasound technology deliver ultrasound waves into the brain.
“We’re extremely excited by this innovation of treating Alzheimer’s disease without using drug therapeutics.”
QBI ANNUAL REPORT 2015 Clem Jones Centre for JonesClem Centre Ageing Dementia Research (CJCADR) found that non-invasive that found used be can technology ultrasound In an international breakthrough, QBI scientists at the atthe scientists QBI international an breakthrough, In to Alzheimer’s treat disease restore memory. and o n t e e l ne He said the new treatment method could revolution- ise Alzheimer’s treatment by restoring memory Götz in the brain that resulted lossand inmemory broke the neurotoxic apart amyloidplaques CJCADR DIRECTOR PROFESSOR said theinnovative,said drug-free approach Alzheimer’s breakthrough uses ultrasound technology uses ultrasound Alzheimer’s breakthrough Jürgen .
“With an ageing population placing an increasing increasing an placing population ageing an “With “In contrast, this method uses relatively inexpen “I think this really does fundamentally change our “The ultrasound waves oscillate tremendously oscillate wavesultrasound “The “We’re extremely excited by this innovation of innovation this by excited“We’re extremely The total number of dementia cases in Australia The approach isable to temporarily open the Alzheimer’s affects more than two-thirds of two-thirds than more affects Alzheimer’s dementia patients, and approximately a quarter quickly, activating microglial cells that digest that cells microglial quickly,activating antibodies will be expensive,” Professor Götz said. and remove the amyloid plaques that destroy that plaques amyloid the remove and sive ultrasound and microbubble technology microbubble and ultrasound sive foresee agreat future forthisapproach.” of amillionAustralians. which is non-invasive and appears highly effective. functions. clear toxic protein and restore clumps memory understanding of how to treat this disease, and I peutics,” Professor Götzsaid. is cost, and other potential drug treatments using is expectedto risetoby 900,000 2050. treating Alzheimer’s without using drug thera - drug using Alzheimer’streatingwithout burden on the health system, an factor important brain synapses. blood-brain barrier, activating mechanisms that - “This “This treatment restored memory function to the “We’re also working on seeing whether this whether seeing on working also “We’re “With ourapproach the blood-brain barrier’s The research findings were published in the jour Amyloid plaques present in the brains of of brains the in present plaques Amyloid Above left: Götz said. degenerative diseases other than Alzheimer’s and same level of normal healthy mice,” healthy normal Professorof level same ahead ofhumanclinicaltrials. being step next the Alzheimer’swith an model, whether this also restores executive functions,restores executive also this whether an Alzheimer's disease mouse model (left panel) are panel) (left model mouse Alzheimer'sdisease an opening opening is only temporary—for a few hours—so nal Research has been conducted using mice with including decision-makingandmotorincluding control.” it quicklyrestores itsprotective role.” method clears toxic protein aggregates inneuro to scale the research inhigher animal models reduced by ultrasound treatment (rightpanel). Science TranslationalMedicine Queensland Brain Institute J A M OR Annual Report 2015 Annual Report D V E . ELOPMENT - - S
8 Major developments Professor Peter Silburn using live-feed imaging during deep brain stimulation implantation surgery. e A a a entre or euro o ulat on
“Integrating research into the clinical setting helps us learn more about the brain, leading to improved delivery of healthcare and better health outcomes.”
QBI ANNUAL REPORT 2015 Centre for Neuromodulation (APCN) to boost the the to (APCN) boost for Neuromodulation Centre translation of research findings intothe clinic. of translation findings research QBI has joined forces Asia-Pacific with the QBI conditions,” Professor Sah said. Parkinson’s,treat other to among stimulation braindeep of use the intoresearch clinical ing “APCNground-breakof decades two on builds tion treatment. neuromodula in leader research Pacific Asia an was APCN said Sah Pankaj Director QBI greatest humanbenefit. the for care clinical and education research, of sign of their joint commitment to the integration In January 2016 APCN officially joined QBI, in a ran e o neurolo al or er better and more cost-effective therapies for a St Andrew’s War to Hospital, Memorial develop tiative of The University and Queensland of APCN WAS FOUNDED in 2012, asajointini - - -
Current APCN research programs include: working alongsidethem,” hesaid. to forward look and QBI, to students and tists scien 12 of “Weteam their and them welcome treatments. new to discovery scientific building-block from “They’re committed to following through research deep brain800 (DBS)procedures. stimulation than more performed APCN’shaving success, Associate Professor Terry Coyne, are central to “The lead clinicians, Professor Peter Silburn and single goal:to improve qualityoflife. ferent backgrounds to work together towards a “APCN brings together researchers from very dif- • • • functionality ofnewDBSdevices.functionality recording devices to improve the design and Testing next-generation stimulation and trial is one of the first of its kind in the world. ant obsessive compulsive disorder (OCD). This DBS devices in patients with treatment-resist Inserting first in-human “sense and respond” and personalisationoftreatments. disease using GPS to measure quality of life, Remote monitoring of people with Parkinson’s e A a a entre or A a a entre e euro o ulat on - - National ScienceWeek public lecture. by researchers to study movement at an APCN-hosted Above left: Dr Peter Poortvliet demonstrates tools used and thepublic,” hesaid. seminar series, sharing their work with scientists “We encourage APCN to play a role in our vibrant trained by Peter and Terry. wereAustralia in clinicians DBS the of “Most andclinicians. of scientists educating the community and the next generation Professor Sah also noted APCN’s commitment to Queensland Brain Institute J A M OR Annual Report 2015 Annual Report D V E ELOPMENT S
Major developments Dr Ingo Schiffner studies how birds navigate through patterned environments to understand how they regulate flight speed. earn n a out t e r an t e ee elp a t
“By mimicking birds, we can look at developing systems that can more easily adapt to different speeds and conditions such as landing, cruise and take-off.”
QBI ANNUAL REPORT 2015 vision in flight is guiding thevision design guiding flight in is of future autopilots and unmanned aerial vehicles. aerial unmanned and autopilots Research into how use bees and birds A QBI STUDY Researcher Dr Ingo Schiffner said understanding to thedesign ofmore flexibleaircraft systems. how speed control worked in birds could lead could birds in worked control speed how u e ual ue to u e an a u t t a r pee thehumblebudge that shows earn n t e r a out an t e ee elp a t rigar rigar
“By mimicking birds, which have similar flight con “In the most extreme case, the birds increasedbirds the case, extreme most the “In “When we moved the pattern in the same direction “We wanted to see if birds, like honeybees, control The team conducted more than 500 flights under flow,” DrSchiffnersaid. speed of the environment, and thus cause them cruise landing, as such conditions and speeds systems that can more easily adapt to different developingat look can we planes, as straints as their flight, this would reduce the apparent the reduce would this flight, their as various conditions to see how well birds adjusted and take-off,” DrSchiffnersaid. Optic flow is the apparent speed of an image in ence intheireyes. Budgies flew down a long tunnel lined with projec pattern was moved in their flight direction at a at direction flight their in moved was pattern their air speed by about 50 per cent when the when cent per 50 about by speed air their to faster fly to compensate. optic the regulating by flight their of speed the than they actuallywere. tors displaying moving patterns to make the birds experi birds that environment surrounding the their speedto imposedchangesinopticflow. high speed. believe they were flying either faster or slower or faster either flying were they believe - - - “The current generation of biologically inspired biologically of generationcurrent “The “We think this asymmetry is due to due is “We aero the asymmetry this think “However,occur.not did the opposite When the “However, the bird research may be more readily The The research was published in the Nature journal Chequered tunnels are used to observe to used are tunnels Chequered Above left: flight is more like theflight of a fixed-wing aircraft Scientific Reports dynamic andenergy constraints thatbirds vision, and is most applicable to helicopter-liketo applicable most is and vision, applicable to fixed-wing aircraft, because bird aircraft, because fixed-wing to applicable aircraft,” hesaid. QBI’s Professor Mandyam Srinivasan said com experience inflight.” planes orunmannedaerialvehicles. could birds and honeybees of parativestudies patterns movedpatterns thedirection against the flight, unmanned aerial vehicles is derived from insect than ahelicopter,” hesaid. be applied to future autopilots for commercial for autopilots future to applied be birds barely reduced speed. theirflight honeybee flight. . Queensland Brain Institute J A M OR Annual Report 2015 Annual Report D V E ELOPMENT - - S
Major developments L–R: Dr Rosina Giordano-Santini, Dr Sean Coakley and Casey Linton contributed to the discovery published in the prestigeous journal Nature. er e re enerat on e an unlo e
“The moment there is a cut to the nerve, there is a change in the membrane composition, which acts as a signal to the other part of the nerve, saying ‘I am in danger, come save me.’ ”
QBI ANNUAL REPORT 2015 remarkable ability to self-healremarkable ability may hold the secret tosecret treating injuries nerve in humans. A small transparent roundworm with the A small transparent “This “This will now open new avenues to try to exploit solving nerve injuries,”solving nerve hesaid. Project leader Associate Professor MassimoProfessor Associate leader Project physiology, and hopefully move towardsfurther Hilliard said the findings provided hope for treat- ing nerve injuries. ing nerve this knowledge in other systems closer to human roun or to u e a to et er ular IN 2015, QBI scientists discovered the molec QBI 2015, IN mechanisms that allow severed nerves in -
“We study the roundworm species species roundworm the study “We “But a combined approach“But acombined biol molecular using “Neurosurgery alone to fix nerve injuries by effec “We’ll to now try understand if a similar process such as spinal cord injury or vascular damage vascular or injury cord spinal as such an ideal model for studying the nervous system. and known genetics allow us to easily understand also from QBI, said the control. motor or sensory as such abilities for function where healthyneurons were injured. clinical outcomes, and perhaps treat conditions deliverto future the in biology molecular with to worms from learned have we what use can ogy might create an environment that is much is that environment an create might ogy we doesn’t,how it if and, vertebrates in occurs Nerve injuries can take on many forms, from tem porary to permanent, and can involve impairedinvolve can and permanent, toporary Dr Hilliard said neurosurgery could be combined HilliardDr neurosurgery said combined be could Research paper lead author Dr Brent Neumann, Neumann, Brent Dr author lead paper Research may we and regeneration, for conducive more towardsup it scale then and happen it make to enable healing.” the processes that occur inside its body,” he said. tively trying to stitch together broken nerves has humans.” because its transparency,its structure,because simplistic be able to deliver molecules that act as a glue a as act that molecules deliver to able be had limitedsuccess,” hesaid. er e re enerat on e an er e unlo e C. elegans roundworm was C. elegans - - -
“This is really interesting, because it resembles it because interesting, really is “This “The moment there is a cut to the nerve, there is “This “This meant we were able to progress rapidly, and The research was funded by the National Health Associate Professor Massimo Hilliard (right) is senior senior is ProfessorHilliard(right) Associate Massimo Xue said. Above left: Dr Brent Neumann (left) is lead author, and go from a description of what happens, to under saying ‘I am in danger, come save me,’ ” Professor and Medical Research Council, the Australianthe Council, Research Medical and changes it and dying is cell a when apoptosis, another biological process inhumans called acts as a signal to the other part of the nerve, the of part other the to signal a as acts a change in the membrane composition, which said knowledge of them helped the researchers standing the very process of how it happens on a geneticandmolecularlevel.” for quickremoval.” covered some of the molecules used in the study, author ontheNature publication. Health, and was published in the journal Research Council and the National Institutes of Professor Ding Xue, from collaborating partner collaboratingpartner fromXue, ProfessorDing understand theregenerative mechanism. the membrane compositionandmarksthecell the University of Colorado, Boulder, who first dis Queensland Brain Institute J A M OR Annual Report 2015 Annual Report D V E ELOPMENT Nature . - - S
Major developments Professor Justin Marshall (right) and Sir David Attenborough (left) explored the Great Barrier Reef in a yellow submarine. Diving with the stars Photo courtesy of Atlantic Productions.
“To sit side by side with Sir David Attenborough in a submersible at 300m and help interpret the natural history of the Great Barrier Reef was a biologist’s dream come true.”
QBI ANNUAL REPORT 2015 with Sir David Attenborough on a documentary Davidwith Sir a documentary on Attenborough laboratory, Professor worked Marshall, Justin In 2015In head of the QBI’s ecology sensory series about the Great Barrier Reef. Great series the about This included a 10-day exploration and filming and exploration10-day a included This ago. Professor Marshall said that working with with working that said Marshall Professor ago. ough's expedition aboard the MV ago, Professor Marshall’s new role wasaschief co-ordinating scientist onSir David Attenbor o u entar e t r a a out e ear er e er e to e reene on t e A n Apr l 201 research vessel and its submersibles were used to take Attenborough back to an environment an to back Attenborough take to he first visited as a scuba diver almost 60 years HAVING PROVIDED INPUT
Great Reef, Barrier Alucia a three-part television television athree-part . on theFirst Life The cutting-edge cutting-edge The -
“He is totally committed to getting the facts right “Mantis shrimps have different adaptations different have shrimps “Mantis Attenborough acknowledged Professor Mar Professor acknowledged Attenborough Along with other researchers at UQ, several new Attenborough, the greatest interpreter of the nat during theshootwastoduring factcheckthescience discoveries from Professor Marshall’s neurosci dream cometrue,” hesaid. great expert on mantis shrimps—was our chief our shrimps—was mantis on greatexpert and where my knowledge failed, I could point could I failed, knowledge my where and advisor,”scientific hesaid. which shrimps, mantis on expertise shall’s side with Sir David Attenborough in a submersible and engineeringtechnologies. at 300m and help interpret the natural history of visual system which we are only just beginning would would have the answers,” Professor Marshall said. for this series. These included the complex vision featured inthe series. TV of polarised light, has applications for medical for applications has light, polarised of of mantis shrimps and colour communication in ence research were picked up by Attenborough reef systems. This research, including the use the including research, This systems. reef David and the team to other scientists I knew I scientists other to team the and David David presented. jobs his of one that said Marshall Professor ural world, was a great privilege. “To sit side by side“To privilege.sit great a was world, ural the Great Barrier Reef (GBR) was a biologist’sa was (GBR) Reef Barrier Great the to understand and fortunately Justin—who's fortunately and a understand to but they also have an extraordinarilycomplex an have also they but - - - “Let’s hope that we can ensure the wonders of our “It was fantastic to use this science platform for its Above left: film andshare this informationthrough Sir David submersibles, submersibles, however, comprised a high-end sci Council Linkage project. Headed by Professorby Headed project. Linkage Council started started CoralWatch 12 years ago, a citizen-science and Atlantic Productions,” Professor Marshall said. at www.attenboroughsreef.com. was filmed in virtual reality(VR). This finishedVR experience has been playing to sell-out crowds at contributor to research at UQ we are seeing on the reef and exploring ways to that dive a completed David when Submarine ence support ence vesselsupport for an Australian Research original purpose, to go places deeper than anyone on film.” As part of this effort, Professor Marshall London’s Natural History Museum and will open Professor Marshall also provided scientific con nership nership with Australian explorer Mike McDowell. Professor Marshall was also present in the Triton Marshall, The Deep-Australia Project is a part a is Deep-AustraliaProject The Marshall, reef will be here for future generations, not just just not generations, future for here be will reef Productions, is owned by Ray Dalio, a generous program also aimed at interpreting the changes in April 2016inthe Australian Museum inSydney MV this project which launched in December 2015 December in launched which project this accompany to website interactive the for tent Photo by Roy Caldwell. mantis shrimp that Professor Justin Marshall studies. has been before off the Great Barrier Reef and to keep thereef forfuture generations. Alucia Diving with the stars , the research vessel used by Atlantic , a species of species a Odontodactylus, scyllarus Queensland Brain Institute J A M OR Annual Report 2015 Annual Report D . The shipand V E ELOPMENT . - - - S
Major developments Research groups QBI ANNUAL REPORT 2015 was appointed as the Stafford Stafford the as appointed was Fox Senior Research Fellow. In 2015, Dr Steven Zuryn Zuryn Steven Dr 2015, In
Research groups Research 2015 was another outstanding year for QBI, world-class research. world-class with our scientists in 35 laboratories producing QBI scientists study brain processes, disorders development through to later life. and diseases that have relevance from early
Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR S ROUP
Research groups Research groups QBI ANNUAL REPORT 2015 connections in a dish. Winner, 2015 2015 Winner, adish. in connections cortical neurons making synaptic NHMRC Art in Science Award. Award. Science in Art NHMRC “In Search of Memory”:
Jocelyn Widagdo,DesmondWoo. Image:Proposed modelfortherole ofprotein ubiquitinationinmediatingAMPA receptor intracellular endosomalsorting. AMPA-type glutamate receptors are essential for Mechanisms glutamate underlying receptor turnover various neurological disorders, such as Alzheim autism. autism. The major aim of the Anggono group is to and inhibition, which often results in the memory apses. Dysregulation of AMPA receptor trafficking er’s disease, schizophrenia, bipolar disorders and excitatory synaptictransmission inthemam 2015 laboratory2015 membersL–R/T–B: Victor Anggono, Yu Qian Chau, Sumasri Guntupalli, Se Eun (Joanne) Jang, Simran Kaur, Daniel Lim, Men Chee Tan, Chenxi (Tracy) Wang, neurons to modulate the strength of their connec results inan imbalance inneuronal excitation understand thedetailed molecular mechanisms malian central nervous system. The ability of ability The system. nervous central malian impairment and cognitive deficits associated with in by part the number of these receptors at syn tions, termed synaptic plasticity, is determined determined plasticity, is synaptic termed tions, - - - -
AMPA receptor ubiquitination, subsequently lead dependent manner. They mapped the sites of sites the mappedmanner. Theydependent four AMPA receptor subunits (GluA1-4) undergo undergo AMPA(GluA1-4) four subunits receptor all discoveredthat group Anggono the 2015, In carboxyl-terminal tails of GluA1 and GluA2 sub GluA2 and GluA1 of tails carboxyl-terminal recycling-endosomes. As a consequence, these these consequence, a As recycling-endosomes. post-translational ubiquitination in an activity- an in ubiquitination post-translational regulating AMPAregulating synaptictrafficking, receptor pathway and are more stable in neurons. This study, plasticity, learningandmemory. units. Mutation of these lysine residues inhibits inhibits residues lysine these of Mutation units. the in residues lysine specific to ubiquitination mutant AMPA receptors escapethe degradation ing to of mis-sorting AMPA receptors from late- to Laboratory head - -
1000 This paper was recommended by the by recommended was paper This such asAlzheimer’s diseaseandschizophrenia . at at the 25th Meeting of the International Society for which was published in the journal the in published was which Work in the Anggono laboratory was by supported er’s Australia DementiaResearch Foundation. project grants from the NHMRC and the Alzheim Molecular Biologists Congress (Hyderabad, India). Federation of Asian and Oceanian Biochemists and 14th the Australia)and (Cairns, Neurochemistry understanding of several neurological disorders disorders severalneurological of understanding has wide-ranging ramifications, including for our wide-ranging our has ramifications, for including by which AMPA receptors are aberrantly degraded, and formed the subject of invited seminars Dr Victor Dr Anggono Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR Cell Reports Cell Faculty of S ROUP - ,
Research groups Research groups Laboratory head Understanding the regulationUnderstanding and function of hippocampal neurogenesis QBI ANNUAL REPORT 2015 generated from the resident population of stem/ as mood. The group has discovered that the that discovered has group The mood. as with impairments in cognitive function as well as function cognitive in impairments with and age, with declines neurogenesis, called on understanding the mechanisms thatregu themechanisms on understanding Perry Bartlett, Daniel Blackmore, Lavinia Codd, Samuel Harley, Dhanisha Jhaveri, Imogen O’Keeffe, Jana Vukovic, Jing Zhao, Jing Vukovic, Jana O’Keeffe, Imogen Jhaveri,Harley, Dhanisha Samuel Codd, Lavinia 2015 laboratoryBlackmore, members L–R/T–B: Daniel Bartlett, Perry physical exercise, antidepressants, and learning. precursor cells in a region of the adult brain adult the of region a in cells precursor Professor Perry Bartlett’s laboratory is focussed majority of these stem cells are quiescent, but quiescent, are cells stem these of majority that they can be activated by stimuli as diverse as this loss of new neurons has been associated been has neurons new of loss this mice juxtaposedto showthe decrease inDCX+ve cells (newneurons) duringthecourseofageing. Zhou. (Alice) Xiaoqing Zhou, Mei known as the hippocampus. This process, This hippocampus. the as known late late the production and function of new neurons, Richard Wang, Weichuan Mo (based in China). in (based Mo WeichuanWang, Richard Not pictured: Professor Perry Bartlett Professor Perry -
The Bartlett group is now focussed on identifying geneity. The study examined the responsiveness deficits in mouse models of ageing dementia, ageing of models mouse in deficits stroke, anddepression. anxiety In a study that was featured on the front cover of cell activation, and on using this knowledge to knowledge this using on and activation, cell cell-sorting method to purify, for the first time, first purify,the to for method cell-sorting of individual precursors to various stimuli and stimuli various to precursors individual of enhance enhance neurogenesis and ameliorate functional Bartlett Bartlett laboratory reported development of a new the the the molecular mechanisms that regulate that mechanisms molecular the stem hippocampal stem precursorhippocampal stem to cells homo near Journal of Neuroscience of Journal (Jhaveri Photomicrographs from 10-week-, 12-month- and 24-month-old 24-month-old and 12-month- 10-week-,Photomicrographs from Image: et al. et ), ), the - different ofthehippocampus. functions different. Since it has been shown that neurons generate neuronal progeny that are molecularly showed showed that these distinct precursors are located anxiety and mood are located in different areas cursors in the hippocampus. The study further further study The hippocampus. the in cursors of the hippocampus, it suggests that it is the is it that suggests it hippocampus, the of regulating spatial learning and those regulating precursor populations that may underpin the preferential activation of one of the two distinct provided the first evidence for the presence of presence the for evidence first the provided in different regions of the hippocampus and hippocampus the of regions different in two distinct subpopulations of quiescent pre quiescent of subpopulations distinct two -
“Real” stem cells in the hippocampus of an an of hippocampus the in cells stem “Real” adult mouse; identified by the presence of of presence the by identified mouse; adult Image by Dhanisha Jhaveri. Dhanisha by Image EGF receptor on their cell surface (black dots). dots). (black surface cell their on receptor EGF
RNA demethylase FTO in the the in FTO demethylase RNA Protein expression of the medial prefrontal cortex.
The extinction of conditioned fear (the reduc (the fear conditioned of extinction The Jenny Wang, Wei Wei. Notpictured: SrjanaKishore. infusedinto Image:PiwilshRNA thedorsalhippocampus. quence) is an important model for the treatment Epigenetic mechanisms regulating memory regulating mechanisms Epigenetic of research referred to asepigenetics. on co-ordinated geneexpression andthesyn of anxiety disorders. Like other forms of learning, Timothy Bredy, Danay Baker-Andresen, Chuan Yang (Michael) Dai, Laura Leighton, Xiang Li, Krista Mitchnick Vikram Ratnu, Vikram Mitchnick Krista Li, Xiang Leighton, Laura2015 laboratory members L–R/T–B:Dai, Yang(Michael) Chuan Baker-Andresen,Bredy, Danay Timothy repeatedly presented without any adverse conse ulate chromatin structure, a relatively recent field involves a tightly controlled interplay between interplay controlled tightly a involves transcriptional machinery and enzymes that reg that enzymes and transcriptional machinery processproteins. This synaptic new of thesis tion in response to a feared cue when the cue is long-lasting memory for fear extinction depends - - - - ation, histone modifications and the activity of activity the and modifications histone ation, It was a productive year for the laboratory, which epigenetic mechanisms, including DNA methyl- epigenetic mechanisms, including DNA non-coding RNAs, regulate the formation and formation the regulate RNAs, non-coding published a ground-breaking new study on the on study new ground-breaking a published maintenance ofmemory.maintenance ment through epigenetic modifications, and how Research intheBredy laboratory iselucidating this relationship shapes behaviour throughout behaviour shapes relationship this how the genome is connected to the environ the to connected is genome the how life. The group is particularly interested in how in interested particularly is group life. The Laboratory head - Janelia Research Campus. sure, with invited talks at severalinternational at talks invited with sure, addiction. The work received significant expo significant received work The addiction. work, which appeared in the journal journal the in appeared which work, collaborators that neuron-specific changes in changes neuron-specific collaboratorsthat genetics role of long non-coding RNAs and neural plas neural and RNAs non-coding long of role DNA methylation are associated with cocaine with associated are methylation DNA Neuroepigenetics and Behavioral Epigenetics at meetings, including the Keystone conference on ticity in the journal , the group demonstrated together with Dr Timothy Dr Bredy Queensland Brain Institute Biological Psychiatry S E R Annual Report 2015 Annual Report CH G CH EAR Neuroepi- . In other Inother S ROUP - -
Research groups Research groups Translation of cognitive tasks for animal models of neuropsychiatric disorders The group has been exploring the impact of impact the exploring been has group The Associate Professor Thomas Burne’sProfessor Thomas group Associate Aung Aung Moe, Chris Simpson, Karly Turner,Karly Simpson, Vega.Chris Sanchez Moe, Michelle Aung Aung Laboratory head QBI ANNUAL REPORT 2015 development, the impact of adult vitamin D defi brain on deficiency D vitamin developmental studies brain development and behaviour in behaviour and developmentbrain studies animal models. The group is focussed on focussed is group The models. animal ways to assess cognitive behaviour in rodents. ciency on brain function and behaviour and, behaviour and function brain on ciency finding of goal the with schizophrenia, for attentional performance ismeasured.attentional performance Thomas Burne, Suzy Alexander, Md Mamun Al-Amin, Kyna-Anne Conn, Natalie Groves, Lachlan Harris, Pauline Ko, Emilia Lefevre, Emilia Ko, Pauline Harris,2015 laboratory Groves,Lachlan members L–R/T–B:Natalie Conn, Kyna-AnneAl-Amin, Alexander,Mamun Suzy Md Burne, Thomas public health interventions that will alleviate will that interventions health public more recently, has been establishing novel establishing been recently, has more investigating the underlying biological basis biological underlying the investigating the burden ofthisdisease. Associate Professor Burne Thomas - autism, schizophreniaautism, anddepression. associated with alterations in behaviour, brain neuro In 2015, the Burne group built on previous research chemistry chemistry and receptor profiles. They have discovered on neurotransmitter systems that are affected in a in affectedare that neurotransmittersystems on on low prenatal vitamin D (the “sunshine hormone”) number of neuropsychiatric conditions, including conditions, neuropsychiatric of number mice mice to show that adult vitamin D deficiency impacts in rodents. These results provide the first evidence in ters in the brain, and also alter cognitive behaviour cognitive alter also and brain, the in ters that low vitamin D levels during adulthood affect the to show that adult vitamin D deficiency is also is deficiency D vitamin adult that show to balance of excitatory and inhibitory neurotransmitinhibitory and excitatory of balance A novel signal detection task where rodents are trained to obtain food rewards whilerewards food obtain totrained are rodentswhere task detection signal novel A Image: - - The Burne group has also created and vali and created also has group Burne The dissect the exact neuralexact the dissect pathways involved in dated dated a unique cognitive task for rodents that and drug treatment of cognitive symptomscognitive of treatment drug and Ongoing NHMRC funding allows the group to cognitive symptoms ofschizophrenia. cognitive impairments of attentional processing uncover more about the pathophysiology the about more uncover mirrors the continuous performance task in task performance continuous the mirrors the model to animals D–deficient vitamin in in schizophrenia. tool for cognitive research in rodents and to and rodents in researchcognitive for tool humans. humans. The group’s goal is to provide a novel - Doublecortin and GFAP expression in the hippocampus of an adult mouse. adult an of hippocampus the in
suggests thesuggests mammalian brain may for learning spatial information. use a probabilistic mechanism use a mechanism probabilistic Playing dice: recent evidence
The core research of the Cheung laboratoryCheung the of researchcore The The 2014 Nobel Prize in Physiology or Medicine Understanding spatialUnderstanding computations in the mammalian brain sensory uncertainty sensory seminal contributions to the identification and identification the to contributions seminal characterisation of cells in the rat brain that brain rat the in cells of characterisation made who scientists three to awarded was toback go and home, returnresources, for computations required for animals to search oldest and most widespread brain functions a new computational model can probabilistically combine information encoded by two known cell types (grid and boundary cells), able to learn under realistic levels of of levelsrealistic under learn to able cells), boundary and (grid types cell known two by encoded information combine probabilistically can model computational new a 2015 laboratory members T–B:Nolan. Chris Cheung, Allen research worldwide. theof one is navigation Spatial navigation. is aimed at understanding the fundamen the understanding at aimed is in in the animal kingdom. The cells, circuits and those resources later are subjects of intense spatial for required computations brain tal . - abilistic learning and recall. This provides theprovides recall.This and learning abilistic consistent with a single mechanism of prob of mechanism single a with consistent encode space (e.g., grid cells and place cells). place and cells grid (e.g., space encode oratory recently found that diverse response diverse that found recently oratory remains unknown about the computations that recordings in navigating rats, the Cheung lab Cheung the rats, navigating in recordings Despite this significant milestone, a great deal great a milestone, significant this Despite By developing a new spatial information fusion underlie mammalian spatial representations spatial mammalian underlie predictions gridcellfunction. about are “grid cells”, called cells, spatial of patterns model and comparing it to it comparing model and neuronal published most complete explanation of grid cell function to date, and makes a number of new and testable Not pictured:VinayChandragiri, ZoltánLuff.Kósci, Adam Laboratory head . - - The Cheung laboratory is involved in ongoing in involved is laboratory Cheung The dence of a mental map; (4) the development of evi for look to studiesbehavioural human (3) spatial systems. system and its apparent independence from other a model of place cells, which may be used for used be may which cells, place of model a fMRI studies to investigate how the human the how investigate to studies fMRI cell recordings in rats navigating in darkness to and local with collaborativeprojectsresearch path planning; (5) understanding the computa the understanding (5) planning; path investigate the nature of spatial memory; (2) memory; spatial of nature the investigate international neuroscientists, including: (1) place tional mechanisms underlying the head direction tional mechanisms underlying the head direction brain encodes space during virtual navigation; virtual during space encodes brain Bridging cells, systems and computations: computations: and systems cells, Bridging Image: Dr Allen Cheung Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR S ROUP - -
Research groups
Research groups
The brain connectome describes how neurons The Chuang laboratory is developing functional A major focus of the laboratorythe of focus major toA is and map Laboratory head Imaging biomarkers of diseases old. The networkpattern provides abiomarker fordiagnosisandtreatment efficacy. QBI ANNUAL REPORT 2015 develop drugtherapeutics. specific diagnosis, optimise treatment and treatment optimise diagnosis, specific are wired and interact. It is a critical compo critical a is It interact. and wired are and molecular imaging to understand the neural characterisation of diseases and their progress; connectivity as biomarkers could improve the ease-specific patterns of brain activity and activity brain of patterns ease-specific dis Identifying diseases. of endophenotypes white matter deficits in a mouse model of Huntington's disease. Atrophy can beseen in thestriatum and the corpus callosum in the pre-symptomaticstage at 1½ months 2015 laboratory members T–B: Kai-Hsiang Chuang, Hussein Srour. Image: Structural MRI(left)and diffusion tensorimaging(right)detectprogressive gray matterand nent for linking behaviour with cellular and cellular with behaviour linking for nent understand understand the functional connectome in vivo. molecular changes. Many neurodegenerativeMany changes. molecular the Chuang group aims to facilitate early and early facilitate to aims group Chuang the diseas progression (months) progression diseas 1½ 9 6 3 Associate Professor Chuang Kai-Hsiang - - To image large-scale memory-related networks, (MRI) for in vivo staining of the hippocampus, a ganese-enhanced magneticresonance imaging with associated connectivity brain determine and psychiatric disorders show deficits in brain functional connectivity in the rodent brain.rodent the in connectivity functional rodent brain ( connec disease that suggesting networks, nique measuring brain synchrony, to infer to synchrony,brain measuring nique in in the mossy fibres after a memory task in the magnetic resonance imaging (fMRI), a tech a (fMRI), imaging resonance magnetic tomes may progression underliedisease . the group established resting-state functional key region for memory, and detected plasticity behaviour, the Chuang group developed man- developedgroup behaviour, Chuang the Neuroimage 2015). To To - - They identified ongoing synchronous activity synchronous ongoing identified They Aricept®, a drug for treating dementia. Thedementia. treating for drug a Aricept®, assess responsesassess to treatments experimental connectivity imaging in mouse models of neu con- that found and task memory a following over time, in line with current understanding of relationship between the functional connec functional the between relationship rodegeneration to track diseaseprogress and nectivity patterns reorganised toward the cortex potential of fMRI for tracking cognitive func cognitivetracking for fMRI of potential memory consolidation. The connectivity and connectivity The consolidation. memory the group is applying structural and functional toand diseases in effects.tion drug test Now, tome and performance indicates memory the behaviour performance can be enhanced byenhanced be can performance behaviour
Medial pallium
Frontal regions
Somatosensory cortex Hypothalamus
Parietal regions Amygdala
Thalamus Hippocampus Ventral pallium Ventral
Temporal region
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CingulateVisual region cortex
Visual cortex Visual Visual cortex cortex Visual Visual Somatosensory cortex cortex cortex Somatosensory Somatosensory Somatosensory Temporal region region Temporal Temporal
Insular region region Temporal Ventral pallium
Hippocampus
Parietal regions Parietal
Parietal regions Parietal of Huntington's disease. changes in aconnectivity mouse model Resting-state fMRI detects functional
Frontal regions Frontal Hypothalamus regions Frontal
Thalamus Medial pallium Medial
Amygdala CPu pallium Medial Medial pallium
Frontal regions
Hypothalamus Hypothalamus Hypothalamus
Somatosensory cortex Hypothalamus
Parietal regions Amygdala Amygdala Amygdala
Thalamus Thalamus Hippocampus Hippocampus Ventral pallium Ventral
Temporal region pallium Ventral
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Insular region Insular Insular region Insular Cingulate region Cingulate
CingulateVisual region cortex region Cingulate
Visual cortex Visual Visual cortex Visual Somatosensory cortex cortex Somatosensory Somatosensory Somatosensory cortex Somatosensory
Temporal region Temporal Insular region region Temporal Ventral pallium
Hippocampus
Parietal regions Parietal Parietal regions Parietal
Hypothalamus Frontal regions Frontal Frontal regions Frontal
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Medial pallium Medial Amygdala CPu pallium Medial 5-day-old hippocampal neurons. PSD95 clusters (purple) on
Amanda White,NicoleWilson.Image:Human pluripotent stemcellstransform into neural stemcells(orange/pink). Understanding the molecular pathwaysUnderstanding building the brain and synaptogenesis. receptor)Wnt Ryk (a and neuralin cell stem ance receptors Neogenin (a netrin receptor) Current research inthe Cooper laboratory which are equivalent to those seen in humans. of the neocortex. The group has identified has group The neocortex. the of explores the fundamental cellular and molec Helen Cooper, Lily Fogg, Ka Wai Fok, Michael Langford, Vanessa Lanoue, Natalie Lee, Conor O’Leary, Loc-Duyen Pham, Loc-DuyenO’Leary, Conor Lee, Natalie Lanoue, Vanessa Langford, Michael Fok, Wai Ka laboratory2015 Fogg, membersL–R/T–B:Cooper,Lily Helen unexpected, novel roles for the axon guid axon the for roles novel unexpected, ular mechanisms governing the development the mouse leads to cortical malformations cortical to leads mouse the has shown that loss of these receptors inreceptors these of loss that shown has biology, neurogenesis, dendrite outgrowthbiology, dendrite neurogenesis, The Cooper group Laboratory head - - The group’s latest studies are providing a providing are studies group’slatest The signalling pathways ensure the fidelity of fidelity the ensure pathways signalling schizophrenia. andautism The Cooperlabo also uncovered intriguing links between links intriguing uncovered also cortical development. The laboratory has laboratory The development. cortical fundamental insights into the pathophysiol the into insights fundamental of neuropsychiatric disorders. perhaps and malformations cortical of ogy ratory believes that these studies will produce provide some clues to the molecular basis molecular the to clues some provide mechanistic understanding of how these how of understanding mechanistic these receptors and genes associated with with associated genes and receptors these Associate Professor Cooper Helen - - atric disorders. Importantly, to ensure that discoveries are relevantdiscoveriesareto Importantly, that ensureto contribute contribute to malformations and cortical neuropsychi oration with Professor Ernst Wolvetang (AIBN, UQ) to UQ) (AIBN, Wolvetang Ernst Professor with oration neuronal connectivity. The Cooper group will also explore found subtypes neuronal many and cells stem neural pluripotent pluripotent stem cells, which can generate embryonic . in theneocortex investigate these signalling pathways in human induced the human brain, the group has also initiated a collab a initiated also has group brain,the human the the functions of genes known to carry mutations that mutations carry to known genes of functions the hopes to identify new modulators of neurogenesis and Inthecomingyears the laboratory Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR S ROUP - -
Research groups Research groups The Coulson laboratory is investigating how and Laboratory head Understanding the aetiologyUnderstanding of neurodegenerative disease QBI ANNUAL REPORT 2015 (p75 diseases including Alzheimer’s disease (AD) and motor neuron disease (MND). Their work Their (MND). disease neuron motor and Cholinergic neurons in the basal forebrainare basal the in neurons Cholinergic focusses on the p75 neurotrophin receptor neurotrophin p75 the on focusses neurodegenerativein die neurons certain why cholinergic neurons inthe brain andspinalcord. Elizabeth Coulson, Lacey Atkins, Zoran Boskovic, Marie Lou Camara, Michael Milne, Lei Qian, Bree Rumballe, ToniRumballe, Turnbull.Bree Qian, Lei Milne, Michael Camara, Lou Marie 2015 laboratoryBoskovic,Zoran members L–R/T–B:Atkins, Lacey Coulson, Elizabeth Not pictured: NathanHearn.Image: Tree-like neuronal cells(darkblue)are typicalofneurons locatedinthehippocampus(yellow). However, significant loss of these neurons has has neurons these of However, loss significant mortem mortem studies show that they can be selectively important for learning and memory, and post- memory,and and learning for important targets the function of these cholinergic neurons. lost in AD. The current treatment for AD patients in occurs that degeneration cell nerve the larly NTR ) and its role in neuronal loss, particu loss, neuronal in role its and ) Professor Elizabeth Coulson Professor Elizabeth -
The Coulson group has developed a candidate a developed has group Coulson The death signalling pathway and promote cholin promote and pathway signalling death already occurred in the majority of AD patients patients AD of majority the in occurred already cell lossinthisdebilitatingcondition . No paralysis. and tone muscle of loss causing ergic neuron survival. They have had success had have They survival. neuron ergic only efficacious while the neurons are alive, these neurons in the spinal cord selectively die in MND, prior to treatment, and because these drugs are Better drugs are needed. Similarly,needed. cholinergicare drugs Better in a mouse model of MND, showing that a that showing MND, of model mouse a in treatments are of limited value to most patients. therapy (called c29) to to try stop the p75 treatments are effective in treating the underlying NTR -
delayed disease onset. They further demonstrated versity of Adelaide found that a by-product of p75 and the cell death signalling pathway used by used pathway signalling death cell the and a cell signalling survival pathway was activated, could be measured inurineandblood. was found in high levels in people with MND, and not beingactivated to thesame extent. indicating that motorneurondegenerationthat indicating was motor neurons alive for longer, and that treatment treated mice also showed less of this by-product, three-month c29 infusion could keep dying keep could infusion c29 three-month the p75 proteinp75 the to motordying kill neurons was that when mice were given the early-version drug, blocked. In addition, collaborators from the Uni collaboratorsthe fromaddition, In blocked. The c29 c29 The -
A golden hippocampus controls the function of other brain regions. remotely also that one but memory, for vital only — a brain structure not not structure a brain
Sensory-driven and attention-related responses and Sensory-driven attention-related in somatotopic cortex measured at the level of of level the at measured cortex somatotopic in fingertips using ultra-high field (7 Tesla) MRI. (7Tesla) field ultra-high using fingertips
To investigate these brain processes, the Cunning The Cunnington laboratory studies how the brain Brain processes for perception and action settings suchastheclinicand classroom. sensory information, how we make decisionsmake we how information, sensory and predictions influence our perception of this out out these actions. The group not only strives to 2015 laboratory members L–R/T–B: Ross Cunnington, Jeff Bednark, Megan Campbell, Yuan Cao, Georg Kerbler, Kelsey Palghat, Jake Palmer, Alex Puckett, Natalie Rens, processes sensory information, how attention how information, sensory processes make contributions to basic science research, but magnetic resonance imaging (MRI). Recently, the to also translate these findings into real-world into findings these translate also to including electroencephalography (EEG)and to prepare for our own actions, and how we carry ton group employs a wide variety of techniques techniques of variety wide a employs group ton Streamlines are coloured (A) by directionality and(B-D)to illustrate functionalcircuitry. Eva Reuter, Chase Sherwell, Grace Scott, Nathalia Souza. based on this information and our previous states - field (7 Tesla) MRI scanner at UQ to perform high- group has been making use of a new ultra-high new a of use making been has group group is also using diffusion MRI to map structural Otherresearch thein group examines“mirroring” . connections among the basal ganglia and cortex the ganglia, basal the within activity functional Complement movements. voluntary of control and planning higher-order for crucial are which ganglia, basal the of circuitry fine the of function resolution imaging. Specifically, the group is using processes that are important for our ability to ability our for important are that processes underlying touchunderlying to and sensation the examine ing the use of ultra-high field MRI to study the study to MRI field ultra-high of use the ing this scanner to examine the cortical processes this scannerto examinethecortical Mildred TaupinNot pictured: . Laboratory head Image: Connections between basal ganglia assessed and bycortex tractography. Professor Ross Cunnington Cunnington Professor Ross -
for empathy, how these processes are disrupted contribute to learning in group co-operative activ children inschool classrooms and applying com Australianthe with Research Council’s Science of their mirrored neurological or brain states, may engagement between children, down to the level of Learning Research Centre, the group is meas neural mirroring brain and processes important putational modeling to examine how shared how examine to modeling putational perceive and understand others. In association uring biological markers of brain states between in people suffering from depression, and potential ities. In addition, the research group is examining therapies to target theseprocesses. Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR S ROUP - - -
Research groups Research groups The Dickson laboratory investigates the investigates laboratory Dickson The Laboratory head QBI ANNUAL REPORT 2015 direction, speedandgait. Locomotor Drosophila in circuits across each leg joint and all six legs, and legs, six all and joint leg each across fruit fly, 2015 laboratory2015 members T–B:Feng. Kai Dickson, Barry neural circuits that control walking in the in walking control that circuitsneural nerve cord produce rhythmic motor pat motor rhythmic produce cord nerve modulate modulate these operations to alter the fly's is to understand how local circuits in the in circuits local how understand to is terns, how these patterns are co-ordinated perturbation experiments. perturbation how descending signals from the brain the from signals descending how Drosophila melanogaster . Professor Barry Dickson Professor Barry The goal goal The -
The lab started operation August QBIin at . 2015 The labstarted should be possible to bepossible should explore systematically operating the output of one specific cell type. With this approach, it approach, this With type. cell specific one of output nervous system. nervous and reporters activity encoded Genetically cord. nerve principles of the locomotor circuits in the fly's centralthe in circuits locomotor the of principles populations of neurons while acutely manipulating the modulators, together with fast volumetric imaging, make it possible to simultaneously monitor the activity of large needed equipment the up set to was task immediate to measure and manipulate neuronal activity in the live The Thorlabs microscope for fast volumetric activity imaging, modified for cell-type-specific activity activity cell-type-specific for modified imaging, activity volumetric fast for microscope Thorlabs The Image: The This system was almost fully functional by functional fully almost was system This (2) investigating how activity patterns in the in patterns activity how investigating (2) year's end, so that the group can now focus now can group the that so year's end, expanding the collection of genetic tools genetic of collection the expanding further (1) goals: complementary three on nerve cord respond to a descending signal descending a to respond cord nerve ing for a complementary descending pathway that triggers backward walking, and (3) search that can be used to target activity modu activity target to used be can that that initiatesforward walking. lators and reporters to specific cell types, cell specific to reporters and lators - -
The central nervous system of Drosophila of system nervous central The (blue), stained to reveal a single descending neuron that reverses walking direction (yellow).
Top: Dopamine synthesis is increased in the substantia nigra nigra substantia the in increased is synthesis Top: Dopamine developing dopaminergic neurons in embryonic rat midbrain. and its projection target, the caudate nucleus, via the use of of use the via nucleus, caudate the target, projection its and a virally delivered Bottom: genetic A construct. snapshot of 1 n 2010 t e e ta l e t at lo aternal le el Schizophrenia prodrome, autism, development, dopamine, vitamin and D deficiency is also a risk factor for impaired social impaired for factor risk a also is deficiency group has now initiated studies into the relationship and one NHMRC grant. Initial results indicate DVD indicate results Initial grant.NHMRC one and In 2015 the group2015 In majordiscoveries:made four change theway the brain develops andfunctions. the systems, dopamine on focus particular a With ophrenia and autism, such as developmental vitamin o ta n a a r a tor or op ren a Darryl Eyles, Suzy Alexander, Asad Ali, Xiaoying Cui, Lachlan Ferguson, James Kesby, Pauline Ko, David Kvaskoff, Emilia Lefevre, Emilia Kvaskoff,Kesby,David Ko, James Ferguson,Pauline Lachlan 2015 laboratory Cui, members L–R/T–B:Xiaoying Alexander, Ali, Suzy Asad Eyles, Darryl national collaborations funded by two NIH grantsNIH two by funded collaborations national D (DVD) deficiency and maternal immune activation, Eyles laboratory focusses on how risk factors for schiz Leon Luan, Greg Medely, Aung Aung Alice Petty, Moe,KathieOvereem, Renata Pertile, Simila,StephenieVuillermot.Tim Reeks,Henry behaviour inchildren, inparticular. andautism between DVD deficiency and autism, with five inter The The - - science (currently under review) has tremendous trans vitamin D exerts direct control over dopamine and turnover. In 2015, using human cell sys cell human turnover.using and 2015, In early abnormalities in dopamine development abnormalities indopaminetransmission . a t at on o el o op ren a This work 2 op ren a lo el a o ate t a o ate lo el op ren a 2 e roup olla orat on n ur a no symptom phenotypes inamaternalimmune shown vitamin Discapable ofblockingall production via the vitamin D receptor ( receptor D vitamin the via production tems, tems, the group described for the firsttime how lab’s work in DVD-deficient animals confirms animals lab’sDVD-deficient in work lational potential. , 2015). Laboratory head Neuro- The The - - Professor Eyles Darryl u ort al opa ne te are pre are te opa ne u ort al dopamine abnormalities were pre-symptomatic developed a model of this important aspect of all current agents directed against preventing with the clinical group who first showed that showed first who group clinical the with pto at all pera t e n op ren a Using a novela Using toused construct genetic treat nomenon inananimalmodel. Parkinson’s disease (Lund University), the group in patients at Imperial College London, the Eyles the schizophrenia prodrome. the clinicaltransition to schizophrenia. that, using this model, they will be able to trial lab were able to completely replicate this phe Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR The group hopes Incollaboration S ROUP -
Research groups Research groups Laboratory head Computational, systems and developmental neuroscience QBI ANNUAL REPORT 2015 during development. This includes how grow how includes development.This during and computational techniques. and computational mathematical experimental, of combination a One area of focus is how nerve fibres are guided code sensory information. sensory laboratorycode The uses 2015 laboratory members L–R/T–B: Geoffrey Goodhill, Lilach Avitan, Brendan Bicknell, Kelsey Chalmers, Nicholas Hughes, Elizabeth Kita, Margaret Maallo, Huyen Nguyen, resentations of visual inputs form in the optic the in form inputs visual of resentations Professor Goodhill’s laboratory is interested in interestedGoodhill’sProfessor is laboratory make guidance decisions, how map-like rep map-like how decisions, guidance make in in the developing nervous system. The laboratory ing nerve fibres (axons) use molecular cues to cues molecular use (axons) fibres nerve ing tectum and visual cortex, tectum and and how visual these cortex, maps Pranesh Padmanabhan, ZacPujic,BiaoSun.Image: The tipofarat axon stainedfordifferent cellularcomponents. how brains process information, particularly information, process brains how by molecular gradients to find appropriate targets Professor Geoffrey Goodhill Professor Geoffrey - - surprisingly weak. In 2015 the laboratory waslaboratory the 2015 In weak. surprisingly Council ProjectCouncil grant to thiswork. continue awarded a National Health and Medical Research which sensory experience modifies the struc the modifies experience sensory which Once nerve fibres have reached their targets, their reached have fibres nerve Once connections are refined by neural activity. neural by refined The are connections of nerve fibres in response to gradients is often revealing anewformofbrain plasticity. recently found that the trajectories nerve fibres matical model. This model explains why turning ture of these connections in the visual system, visual the in connections these of ture take gradients in by described be can amathe laboratory recently discovered a novel way in way novel a discovered recently laboratory - - The group is also using fluorescent labelling tech simple visual stimuli. By using mathematical tech ally present, and determine how these patterns change over development. A better understanding of neural decoding is important for optimising for important is decoding neural of order to determine what visual stimulus was actu in activity of patterns these decode optimally niques from statistics and information theory, it is niques to visualise the simultaneous activity of of activity simultaneous the visualiseto niques many many neurons in the developing zebrafish brain, the designofbrain-computer interfaces. then possible to predict how the zebrafish could both spontaneously active and in response toresponse in and active spontaneously both - - - of ligand on axon guidance. different concentration gradients Mathematical modellingMathematical of distance (microns) distance (microns) distance (microns) 200 200 200 100 100 100 0 0 0
1 4% 1%
0% the synaptic protein PSD95 (purple/pink) Mouse hippocampal neurons expressing and cytoskeleton protein actin (yellow). actin protein cytoskeleton and
Alzheimer’s disease: basic mechanisms and therapeutic interventions Zala Skrbis. Australians suffering from Alzheimer’sfrom disease sufferingAustralians Australian Research Council and the National the and Council AustralianResearch 2015 has seen significant ongoing funding from dementia, is projectedtodramaticallyis dementia, increase stand disease initiation and progression at a animal models,andto develop novel therapies. and related dementias, including frontotemporal forms part forms of part the Clem Jones Centre for Ageing oneapproximately to currently 320,000 from With With an increasing life expectancy, the number of Jürgen Götz, Siân Baker, J Bertran-Gonzales, Liviu Bodea, Nadia Cummins, Linda Cumner, Xia Di, Harrison Evans, Jasmin Galper,Jasmin Evans, Harrison Cumner,Di, Linda Xia 2015 laboratoryCummins, members L–R/T–B:Nadia Bodea, Liviu Baker, SiânBertran-Gonzales, Götz, J Jürgen Health and Medical Research Council (including Medical ResearchHealth and (including Council under to aims (CJCADR), Research Dementia molecular and cellular level using cellular and cellular using level cellular and molecular million by 2050. The Götz laboratory,which Götz The 2050. by million Robert Robert Hatch, Gerhard Leinenga, Chuanzhou (Joe) Li, Miriam Matamales, Rebecca Nisbet, Maryam Odabaee, Tishila Palliyaguru, Matthew Pelekanos, Juan-Carlos Polanco, both the State and Federal Government, the Government,Federal and State the both Not pictured: Annvan derJeugd. - A scientific highlight was the publication of a of publication the was highlight scientific A an Alzheimer's amyloid plaque pathology and pathology plaque Alzheimer'samyloid an through as well as disease), neuron motor and frontotemporaldementiaProgramon Grant a ery resulted in significant media attention and attention media significant in resulted ery pilot pilot study in sheep, which will address the prob public interest. Importantly, the novel approach restoring memory functions in mice. This discov reducing of method ultrasound-based novel Foundation). philanthropy(including the Clem Jones Founda tion, the John T Reid Foundation, and Yulgilbarand Foundation, John TReid the tion, having a tau tangle pathology,tangle tau havinga a resultedin but has notonlybeen extended to rodent models lem of ultrasound attenuation that is associated Laboratory head - - - Professor Götz Jürgen Additional projects aim to understand ageing- understand to aim projects Additional amyloid, tau, and Fyn interact in a pathocascade. with the thicker skulls of humans in comparison of thediscovery. excitotoxicity pharmacologically. oratory is in developing tau vaccines and blocking related dysfunction of striatal cholinergic striatal of dysfunction related pathology, how tau impairs the electrophysio the impairs tau pathology,how Regarding therapeutics, a major focus of the lab microvesicles have in the propagation of tau of propagation the in havemicrovesicles interneurons, the role exosomes and larger and exosomes role the interneurons, to mice kinase Fyn are transported in neurons, and how logical properties of neurons, how tau and the and tau how neurons, of properties logical . The ultimategoalisclinicaltranslation Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR S ROUP - -
Research groups Research groups The The Hilliard laboratory is focused on understand Laboratory head QBI ANNUAL REPORT 2015 Molecular mechanisms of axonal development, regeneration, and degeneration different compartments, (2) how the axon main which is the longest of the neuronalprocesses,the of longest the is which axon, the how (1) are: goals research current alongside ahealthyneuron (blue)inalive C.elegans. of the organism, and (3) how the axon can be can axon the how (3) and organism, the of Casey Linton, Ellen Meelkop, Brent Neumann, Fiona Ritchie, Michael Van Der Mark. VanDer Michael Ritchie, Fiona Neumann, Brent Meelkop, Ellen Linton, Casey Massimo A. Hilliard, Justin Chaplin, Sean Coakley, Alessandra Donato, Sam Geraghty, Rosina Giordano-Santini, Eva Kaulich, EvaGeraghty, Giordano-Santini, Sam Rosina Coakley,Donato, Alessandra Sean 2015 laboratory Chaplin, members L–R/T–B: Justin Hilliard, A. Massimo neuronal development, maintenance and repair, repaired when severing damageoccurs. using ing the molecular mechanisms that regulate that mechanisms themolecular ing is subdivided into structurally and functionally and structurallyinto subdivided is tains its structure and function over the lifetime C. elegans asamodel system . A o ate ro e or ll ar a o A The group’s The - - degeneration; and the identification of the of identification the and degeneration; genetics, laser manipulations, and imaging and manipulations, laser genetics, areas. They include: the axonal protective axonal the include: They areas. a made has group Hilliard the approaches, fusion, an axonal repair event in which the two yltransferase ( yltransferase acet tubulin alpha conserved a of function of conserved apoptotic molecules in axonal in molecules apoptotic conserved of Using a combination of molecular biology,molecular of combination a Using number of key discoveries in these researchthese in discoverieskey of number molecular mechanismsthat regulate axonal Cell Reports Cell Apurva Kumar. Apurva Not pictured: , 2014); the role the 2014); , - A degenerating neuron (yellow) can be studied studied be can (yellow) neurondegenerating A Image: This latest discovery on how axonal fusion is fusion axonal how on discovery latest This The Hilliard group has been successful in successful been has group Hilliard The separated fragments of an injured axon rejoinaxoninjuredseparated an fragments of and reconstitute the original tract ( achieved has important implications for medi for implications important has achieved an ARC Discovery Project, an NHMRC Senior NHMRC an Project, Discovery ARC an includes that funding competitive attracting facilitate nerve repair.facilitate nerve cal practice: asimilarstrategy may beusedto Dementia Fellowship. Research Fellowship, and a NHMRC-ARC a and Fellowship, Research Nature , 2015). -
can be visualised in the head (green/blue) (green/blue) head the in visualised be can and tail (yellow/pink) of C. of elegans (yellow/pink) tail and Individual touch-sensitive neurons .
Laboratory head r tao r u Laboratory head A o ate ro e or ll ar a o A organism in which to study the the study to which in organism genetics ofgenetics synaptic function. C.elegans is an ideal model model ideal an is
Understanding the molecularUnderstanding mechanisms of synaptic transmission C. elegans strategy for genetic testing. The Hu group Hu The testing. genetic for strategy Over the last few decades, one of most impor communication in the nervous system. Many cellularmechanisms that regulate neuro focusses on candidate genes to understand 2015 laboratory membersL–R/T–B: ZhitaoHu, Lei Li,Haowen Liu,RameshNarayanan. ofsynapticvesicle exocytosis. Image:Molecularmachinery neurotransmission, provides a cost-effective model organisms have been used to address model to study synaptic function. ish, and octopus. Among these organisms, these Among octopus. and ish, this question, including the mouse, fly, zebraf transmitter release, which drives neuronal drives which release, transmitter neuroscience of field the in objectives tant their functional importance insynapses. importance their functional in role functional its of study the through has been to and been has molecular the understand has emerged as a powerful genetic C. elegans - - - , 1 net re ulat on o napt e le relea e e le napt o re ulat on net 1 studies synaptic proteins that affect release kinetics release affect that proteins synaptic studies and spontaneous fusion. The Hu group focusses on focusses group Hu The fusion. spontaneous and Combining electrophysiological recording, cellular imag are released has broad implications. The speed of the on on circuit development and cognition. The Hu laboratory 2 e ole ular ellular e an o erento e an ole ular ellular 2 e Understanding the kinetics of how neurotransmitters nication rate between neurons and strongly influences neurotransmission limits the efficiency and the commu in two forms: evoked fusion after an action potential, potential, action an after evoked fusion forms: two in ing, molecular biology, and biochemistry approaches, to determinetheunderlyingmolecularmechanisms. the Hu group on: focusses Neurotransmitters can be released be releasecan forms: Neurotransmitters local circuit dynamics. It has also had profound effects Laboratory head - - disease. The Hu lab seeks to understandthe disorders andmotor suchasautism neuron determining thecellularmechanismsunder static synapticplasticitymodulation. spontaneous releasehas beenproposed to functional rolesfunctional ofthese candidate genes. evidence indicates that different fusion different that indicates evidence cal diseases: Recent advances in genomic and napt tran on e e t n neurolo DNA variants associated with neurological with associated variants DNA Increasing forms. release two these pinning machinery machinery is used for the two forms. Although its physiological function is still uncertain, still is function physiological its be important in multiple processes, including bioinformatics technologies have identified have technologies bioinformatics long-term facilitation induction and homeo and induction facilitation long-term Queensland Brain Institute r tao r u S E R Annual Report 2015 Annual Report CH G CH EAR S ROUP - - -
Research groups Research groups Laboratory head QBI ANNUAL REPORT 2015 (www.brainnetome.org)foundation a provides Mapping abnormal brain networks in humans and animals with MRI Convergent evidence has shown that brain that shown has evidence Convergent and psychiatric diseases. and algorithms underpinning the Brainnetome focussed on the “abnormalneurodevelopment” the on focussed laboratory Jiang the from study one 2015, In for integrating the multi-level network features network multi-level the integrating for the are disorders psychiatric most with ciated functions can manifest at different scales within abnormal inter-modularandinter-hemisphericconnectivitiesinsociallyisolatedmice. obtained with various functional and anatomical 2015 laboratory membersL–R/T–B:Liu, TongZhou. CirongYonghui Yang,(Alice) XianfengLi, Jiang, Wu, Xiaoqing Tianzi result of faulty brain networks. The Brainnetome platform, and their applications in neurological in applications their and platform, theory of schizophrenia. Inspired by previous by Inspired schizophrenia. of theory tory is studying basic theory, methodologiestheory, basic studying is tory brain technologies imaging brain networks, and that the malfunctions asso . labora Jiang The Professor Tianzi Jiang - - Translational Psychiatry findings from neonatal brains, the group proposed sponding sponding to lower tissue complexity and potentially Chinese Han population comprising patients from maturation. failurea to reach cortical group The observed observed in the cerebral of cortex schizophrenia four different hospital sites. Significantly increased four sites, despite differences in psychopathology, exposure to antipsychotic medicationandscan patients compared with healthy controls, corre controls, healthy with compared patients ners used for image acquisition (Li and Xie imaging (dMRI) mean diffusivity (MD) should be MD measurements were consistently observed observed consistently weremeasurements MD that an increase in diffusion magnetic resonance in the of cortex schizophrenia patients across all tested this hypothesis using dMRI data from a from data dMRI using hypothesis this tested , 2015). et al. - - , social social isolation. Considering the key role of the socially isolatedmice. studies, in particularly the study of adolescent and hyper-locomotion activities induced by induced activities hyper-locomotion and and was associated with fear memory deficits In addition to findings in humans, the labora the humans, in findings to addition In evident in the dorsolateral orbitofrontal cortex organised brain connectome, which was most orbitofrontal cortex in social behaviours, ado behaviours, social in cortex orbitofrontal revealed that the isolated mice displayed a dis ised connectome. thereby contributingtostructurally a disorgan the orbitofrontal cortex and its neural pathways, tory also made significant progress in animal in progress significant made also tory behavioural examinations, the Jiang laboratory lescent social isolation may primarily disrupt Connection-wise comparison reveals comparison Connection-wise Image: BycombiningdMRIand - - - - Abnormal brain regions are shown in red. grey matter of schizophrenia patients. patients. schizophrenia of matter grey Significantly increased mean diffusivity diffusivity mean increased Significantly found by voxel-based analysis in brain brain in analysis voxel-based by found
Laboratory head Professor Joe Lynch Laboratory head Professor Tianzi Jiang trajectories are shown in colours. different GABA when expressed in HEK 293 cells. Their Their cells. 293 HEK in expressed when A receptors diffuse within clusters
The Lynch laboratory’s major research - inter Structure and function of GABAergicStructure and glycinergic synapses GABA (GABA disrupted in hereditary neurological inhereditary disrupted disorders as a therapeutic target for pain, spasticity, pain, for target therapeutic a as (orange dots) of cortical neuron expressing GABA function of the glycine and GABA and glycine the of function cine receptor (GlyR) has recently emerged for sedative and anxiolytic drugs and the gly est concerns the molecular structure and epilepsy and tinnitus. 2015 laboratory members L–R/T–B: Joe Lynch, Xiumin Chen, Christine Dixon, Nela Durisic, Argel Estrada, Justine Haddrill, Robi Islam, Sharifun Islam, Angelo Keramidas, receptors mechanisms themolecular and inhibitory neurotransmission inthebrain. is discovering new drugs active at these at active drugs new discovering is Kooi Yeong Khaw, Atif Mohammed, Suzanne Scott, Ming Shiuan Soh, Sahil Talwar, Yan Zhang. by which their structures and functions arestructures functions their byand which A A R is an important therapeutic targetR isanimportant R) chloride channels that mediate that channels R) chloride The Lynch laboratory A receptor The The A . - receptors. The receptors at the synapse form tight clusters (bright puncta) while the extrasynaptic ones are more mobile. The ability to remotely control neuronal activity neuronal control remotely to ability The disorders caused by aberrant activity levels, includ- addiction, anxiety and epilepsy. Previous research approach and offers a new tool for defining how receptor” for activating defined neuron popula neuron defined activating for receptor” the recently More animals. behaving in neurons iting electrical activity in defined populations of of populations defined in activity electrical iting inhib for receptor” improvedsilencing “neuronal an of development the to led laboratory the in Parkinson’s disease, neuron motordisease, ing tions in the brain the in tions the brain worksinhealthanddisease. holds promise for treating human neurological human treating for promise holds laboratory has developed a “neuronalactivating a developed laboratory has . This complements the silencing silencing the complements This Laboratory head Image: Superposition of conventional (green punkta) and super-resolution image - - As synaptic GABA synaptic As GABA synaptic GABA vivo. Each isoform exhibits unique pharmacological in possible are isoforms many subunits, of variety and physiological properties, and has a unique role oped techniques for reliably generating “artificial”generating reliably for techniques oped exhibit very different functional properties. Using properties. functional different very exhibit may contribute to their differing functional properties. inhibitory synapses that incorporate the defined the incorporate that synapses inhibitory in brain function. The Lynchdevel recentlyThe function. braingroup in they move at different rates on the cell surface. This that found group the time, real in receptors these high-resolution imaging to track the movement of movement the trackto imaging high-resolution A Professor Joe Lynch R subunits of interest. The group found that A Rs incorporating γ1 and γ2 subunits A Rs are formed from a wide a from formed are Rs Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR S ROUP -
Research groups Research groups Visual mechanisms and visual communication the on Great Barrier Reef The Marshall group’s work is based around ceph Laboratory head fish neuronal structure and function. Using these QBI ANNUAL REPORT 2015 colourful? vision and take a systems approach to neurosci alopod (e.g., squid), crustacean (e.g., shrimp) and With questions such as, such questions With environment. Neuroethology is both lab and field- Australia’s in neuroethology on marine vibrant ence including anatomical, electrophysiological, 2015 laboratory membersL–R/T–B: Justin Marshall, Fanny de Busserolles, Karen Cheney, Wen-Sung Chung, Fabio YakirCortesi, Gagnon, Alejandra Galan, Alan Goldizen, research in the Marshall laboratory is focussed ronment andneeds. model systems, the group uses sensory biology in the real world have been shaped by their envi to both compare vertebrate and invertebrate and vertebrate compare both to Naomi Green, Kyra Hay, Luehrmann, Genevieve DianaKleine,Yi-Hsin Lee,Martin Phillips,GabriellaScata,QamarSchuyler, Sara Stieb,Rachel Templin, Hanne Thoen. how the brains and sensory systems of animals based neuroscience. and Why are octopus colourblind? It aims atunderstanding Itaims Why are reef fish Professor Marshall Justin - - - , The The mechanisms behind colour vision and polar A new gene duplication event discovered by Fabio Academy ofSciences seroles, and in a study led by Genevieve Phillips, and and the cephalopods have been a focus in 2015 vertebrates was discovered by Fanny de Bus de Fanny by discovered was vertebrates unravelthe helping is co-workers and Cortesi with important with discoveriesimportant published in top-tier first example of sexually dimorphic vision in vision dimorphic sexually of example first The vision. colour fish marine of complexity natural environment. methods, along with quantifying light in the in light quantifying with along methods, behaviouraland (transcriptomics) molecular ion inNeurobiology,ion Proceedings National the of isation vision in fish, stomatopod crustaceans stomatopod fish, in vision isation journals such as such journals Current Biology, Current Opin and American Naturalist . - - - 2015 saw lab head Justin Marshall’s Australian Series in Vision Research attainment of a PhD by Genevieve Phillips and PhillipsGenevieve by PhD a of attainment were won by Hanne Thoen, Wen-Sung Chung and postdoctoralawards or fellowship competitive cephalopods and fish respectively. The Shaun Collin, now contains five volumes with volumes five contains now Collin, Shaun Research Council Laureate Fellowship used to used FellowshipLaureate Council Research Fabio Cortesi to continue work on stomatopods, milestones for laboratory members included members laboratory for milestones two more inpress for2016. collaboratorclose with along lab, Marshall the transcriptomics revealed the colour vision capa the commencement of three new PhDs. Highly build a hub for neuroethology in Australia. Other bilities of wrasse, the ocean’s most colourful fish. book series based from Springer Springer - The iridescent eye and body colouration of a pufferfish. Reef fish colours and how how and colours fish Reef apufferfish. of of research in the Marshall laboratory. they are perceived are one of the areas
oscillations (coloured lines) to coordinate information (shapes), relying on neural activity across distant brain areas. Attention filters incoming visual visual incoming filters Attention
The group employs a range of approaches toapproaches of range a employs group The Jessica McFadyen, Valdas Noreika, Abbey Nydam, David Painter, Martin Sale, Cooper Smout, Matthew Tang, Susan Travis, Ashika Verghese, Lisa Wittenhagen. Lisa Verghese,Travis,Tang, Susan Ashika Matthew Smout, Cooper Sale, Painter, Martin David Nydam, Abbey Noreika, ValdasMcFadyen, Jessica
Understanding human attention networksUnderstanding field of neuroscience to enhance learning out learning enhance to neuroscience of field comes throughout life. A particularly important from the sensory world or from internal thought Jason Mattingley, Corinne Bareham, Oliver Baumann, Nicholas Bland, Luca Cocchi, Daina Dickins, Hannah Filmer, Marta Garrido, Garrido, Filmer, Hannah Marta Dickins, Daina 2015 laboratoryCocchi, Luca membersL–R/T–B: Bland, Nicholas Baumann, OliverMattingley, Bareham, Jason Corinne part of the research involves understandinginvolves research the of part processes. They also investigate learning, with Researchers inthe Mattingley laboratory use attention to prioritise information, whether movement, in health and disease. The group is rise gives brain human the how investigate the aim of harnessing new discoveries from the inspired by a desire to understand how people to perception, cognition and the control of control the and cognition perception, to Michelle Hall, Anthony Harris, Luke Hearne, Barbara Jachs, Oscar Jacoby, Roxanne Jemison, Marc Kamke, Delphine Levy-Bencheton, David Lloyd, Natasha Matthews, Matthews, Natasha Lloyd, DavidLevy-Bencheton, Delphine Kamke, MarcJacoby, Jemison,Oscar RoxanneJachs, Barbara LukeHearne, Harris, Anthony Hall, Michelle how perceptual and cognitive processes can processes cognitive and perceptual how be impaired inbrain disorders such as stroke Not pictured: EloiseCrawshaw. . - showing how reversible inhibition or excitation or inhibition reversiblehow showing student Luke Hearne published apaper in are reconfigured dynamically in response to response in dynamically reconfigured are In 2015, researchers in the Mattingley laboratory widespread changes in activity patterns through out the adult human brain. Finally, in a paper a Finally, in brain. human adult the out of a small region of the cerebral induces cortex other work, postdoctoral fellow Luca Cocchi pub Brain Mapping made several important discoveries. Graduatediscoveries. severalimportant made methods. ioural tests, imaging and brain stimulation brain and imaging tests, ioural behav including questions, these investigate increases in the complexity of a cognitive task. In lishedapaper in the Laboratory head showing how brain networks brain how showing Journal of Neurophysiology Professor Jason Mattingley Human Human - - -
Jacoby and Claire Naughtin were all awarded all were Naughtin Claire and Jacoby Associate Director of the ARC Centre of Excel of Centre ARC the of Director Associate 2015 also saw a number of milestones important visual attention. within the human temporal lobe is critical for critical is lobe temporal human the within cil’s “College of and Experts”, was also appointed was invited to join the Australian Research Coun published in Baumann and Luca Cocchi were awarded Pro awarded were Cocchi Luca and Baumann Oliver fellowspostdoctoral addition, In PhDs. region small a that discovered Painter David Research Council. in the Mattingley laboratory. Daina Dickins, Oscar ject Grants by the National Health and Medical and Health National Grantsthe ject by lence forIntegrative Brain Function. NeuroImage Queensland Brain Institute Lab head Jason Mattingley S E R Annual Report 2015 Annual Report , postdoctoralfellow, CH G CH EAR S ROUP - - -
Research groups Research groups The prevention and treatment of schizophrenia prevention treatment The and The McGrath laboratory aims to explore risk fac Laboratory head QBI ANNUAL REPORT 2015 disorders. They focus on non-genetic factors non-genetic on focus Theydisorders. (www.cadencetrials.com). In 2015 the McGrath group commenced a major for psychotic disorders. Funded by the John Cade candidate treatments for those with psychosis with those for treatments candidate Queensland. Queensland Centre for Mental Health Research John McGrath, Helen Gooch, Carmen Lim, Greg Medley, Tim Reeks, Henry Simila, Anna Vinkhuyzen. Anna Simila, Medley,Henry Greg Reeks, laboratory2015 Lim, L–R/T–B: members Tim Carmen Gooch, Helen McGrath, John new research program to find better treatments Professor James Scott (UQ Centre for Clinical for Centre (UQ Scott JamesProfessor Fellowship, and in collaboration with Associate Research), the McGrath group and staff from the tors linked to schizophrenia and other mental international studiesto unravel theinfluence ofgenetic andenvironmental factors ontheriskofmentaldisorders. and local from data using is group McGrath factors. The environmental to exposure of chance the increasing via directly, indirectly disease or a of risk the influence have linked up with clinicians around south-east has has commenced randomized control trials of new The Cadence clinical trials program Professor McGrath John - development. The group has established a new vitamin D (the “sunshine hormone”) during early awarded a prestigious National Health and Health National prestigious a awarded they Burne, ProfessorThomas Associate and In collaboration with Professors Darryl Eyles Darryl Professors with collaboration In research program with Professor Pankaj Sah and Medical Research Council John Cade Fellowship was McGrath Professor 2013, in Previously D andvoltage-gatedchannels. calcium Dr Helen Gooch to explore links between vitamin impact of low vitamin D during gestation on brain the team has been examining the impact of low years recent In modifiable. potentially are that have developed animal models to examine the examine to models havedevelopedanimal brain development and on adult brain function. brain adult on and developmentbrain GWAS fordisease (in collaboration with national and international groups). New projects include an international an include projects New groups). sets sets by exploring gene–environment interactions. studies related to vitamin D in international data study related to psychotic experiences inthe gen stress, cannabis, vitamin D), a more diverse range and a wider range of epidemiological samples epidemiological of range wider a and disorders), mental other schizophrenia, autism, ofrange wider a explore to group the allowed eral community (Harvard University and 19 other of brain-related outcomes (e.g. prenatal and neo natal brain growth, childhood neurocognition, childhood growth, brain natal universities). The group has also been extending modifiable risk factors (e.g. infectious agents, infectious (e.g. factors risk modifiable in Mental Health Research. These funds havefunds Research.These Health Mental in Image: Genetic factors can can factors Genetic - - - The first Cadence clinical trial involves adding sodium benzoate benzoate sodium adding involves trial clinical Cadence first The (BZ) to antipsychotic standard medicines. A commonly used food pathways thought to be implicated in schizophrenia. in implicated be to thought pathways preservative, benzoate can also influence neurotransmitter Laboratory head Professor McGrath John Single molecules trajectories of trajectories Single molecules GluA1 subunits of glutamate glutamate of subunits GluA1 receptors in dendrites.
Vinod Narayana,Vinod Papadopulos,Andreas Tong Wang.(Iris) e an neuronal un erl n e ular tra n vesicles’ approach to the plasma membrane. The allows bound secretory vesicles to access the access to vesicles secretory bound allows casting net effect effectively synchronises the synchroniseseffectively effect net casting In 2015, the Meunier laboratory explored the explored laboratory Meunier the 2015, In on what cause secretory vesicles (containing vesicles secretory cause what on Nature Communications 2015 laboratory members L–R/T–B: Chai, YeHarper,Kvaskov,Jin David Callista RavikiranKasula,Martin, Gormal, Sally Rachel Meunier,Frederic Bademosi, Adekunle neurotransmission. neurotransmitter) to be trafficked, dock at the at trafficked, dock be neurotransmitter)to neurons and neurosecretory cells. They focussed plasma membrane in a concerted manner plasma membrane inaconcerted plasma membrane, and undergo exocytosis,undergo and membrane, plasma F1000, the group provided the first demonstra first the providedgroup the F1000, mechanisms underpinning vesicular trafficking in thereby releasing their content and mediating tion that relaxation of the cortical actin network retrograde BoNT/A-Hc singlemoleculesare shown asoverlying coloured traces. Ina paper published in and highlighted by the . This This - As part of the Clem Jones Centre for Ageing for Centre Jones Clem the of part As acto-myosin II network regulates the reuptakethe regulates network II acto-myosin super-resolution microscopes to uncover how neu capitalised on the recent acquisition of severalof acquisition recent the on capitalised of membrane by bulk endocytosis ( endocytosis bulk bymembrane of Neuroscience Psychiatry Meunier group also discovered that the cortical rotrophic factors are packaged in nanodomains of ration with Professors Damien Keating and Phil presynaptic terminals and then channelled back to presynaptic terminals andthen channelledback to small with cell neurosecretory the from pore Dementia Research, the Meunier laboratory has Robinson andco-publishedastudy in Robinson molecular inhibitorsmolecular oftheprotein dynamin. Phase-contrast image showing nerve bundles extending from a microfluidic channels.microfluidic a from extending Trajectories bundles of nerve showing Phase-contrastimage Image: Laboratory head looking at manipulating the fusion the manipulating at looking , 2015). We pursued our collabo our pursued We 2015). , Journal of Molecular Molecular Professor Frederic Meunier Meunier Professor Frederic - - Chemistry and Biology Chemistry flux of autophagosomes undergoing retrograde demonstrated that synaptic activity controls the diseases that are caused by defects in vesicular such as Alzheimer’s disease, as well as epilepsy. accurately measure free fatty acids and started started accuratelyand acids measurefreefatty established Finally,group transport. the axonal Neuroscience rated free fatty acids in brain cells (Narayana neuroexocytosis involving the production of satu implications for the understanding of a number of to unravel a new pathway in the mechanism of of mechanism the in pathway new unravela to to assay spectrometry mass multiplex first the trafficking, including neurodegenerative conditions the cellbody the . In a study published in the in published astudy In and highlighted in the F1000, they Queensland Brain Institute , 2015). These works have S E R Annual Report 2015 Annual Report CH G CH EAR Journal of Journal of S ROUP et al. - ,
Research groups Research groups The Mowry laboratory aims to identify and identify to aims laboratory Mowry The Laboratory head QBI ANNUAL REPORT 2015 group hopes to characterisefurther the function genome- utilising by achievetothis aims group From loci to susceptibility pathophysiology sequencing, and gene expression studies. The studies. expression gene and sequencing, and unrelated casesandcontrols incollaboration Current studies include: (1) continuing recruit from patients. wide association studies (GWAS), DNA and RNA Thedisorders. related and schizophrenia for genes susceptibility characterise functionally of discovered genetic variants by studying these 2015 laboratory members L–R/T–B:Mowry, Bryan Sathish Periyasamy, Giacomotto, Mantzioris, Jean Bill Filippich, Cheryl IlvanaDzafic, Smith. Heather Suetani, Rachel ment of southern Indian schizophrenia families induced pluripotent stem cells (iPSC) sourced from derived cells neuronal in zebrafish and in Image: Mixed forebrain neurons differentiated from inducedpluripotent stemcells(iPSCs),stainedfortheneuronal marker beta-IIItubulin(green). Professor Mowry Bryan - fied chromosomal region in an Indian sample; Indian an in region chromosomal fied (5) establishing iPSC from selected schizophrenia schizophrenia patientsandamatchedsample with Dr Thara, Director, Schizophrenia Research for European-ancestry schizophrenia from the fromschizophrenia European-ancestry for results latest the with results the comparing of healthy individuals; (3) GWAS analyses in analyses GWAS (3) individuals; healthy of patients and controls inorder to test disease selected of phenotyping neuropsychological resequencing analyses of a previously identi previously a of analyses resequencing and neuroimaging (2) Chennai; Foundation, Psychiatric Genomics Consortium; (4) targeted hypotheses; (6) studying the function of the of function the studying (6) hypotheses; homogeneous homogeneous Indian and Sarawak populations, -
A successful NHMRC grant (2016–2018), “Investi Greer and Associate Professor James Scott James Professor Associate and Greer gating the aetiopathogenic role of autoantibodies group’s top Indian GWAS locus in zebrafish and and particular and disease particular symptoms. The group will receptor acetylcholine muscarinic M1 the against worsen specific symptoms. may antibodies these how investigate further the study tolaboratory Mowry the enable will Judith Professor Associate colleagues, with cellular models. relationship between higher levels of antibodies in patients with first episode of schizophrenia” of episode first with patients in - Motor neurons of a zebrafish azebrafish of neurons Motor larvae, 3larvae, days post-fertilisation.
Laboratory head Professor Mowry Bryan RSC CA3 Mm Am Ent M1 DG PC Hb Pir V1 Cg S2 S1 Th LS IC
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Cg plot (bottom)connectivity of regions in the rat brain following learning spatial tasks. memory DG Ent
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Traumatic and dementia brain injury Traumatic brain injury (TBI) occurs when an exter an when occurs Traumatic(TBI) braininjury The effects of TBI can range from a concussion to spatial learning on a Morris water maze. Correlations are based on reference seeds from the left primary somatosensory area (S1), left primary visual cortex (V1), (V1), cortex visual primary left (S1), area somatosensory primary left the from referenceseeds on based are Correlations maze. water Morris a on learning spatial dementia, have been reported in patients who have sustained a TBI. sustained severe brain damage and even death. Signatured death. even and damageseverebrain a role in Alzheimer’s disease and frontotemporaland Alzheimer’s disease in role a anatomical structure with a cascade of deleterious with anincreased riskofearly-onsetdementia, as changes to molecular, cellular, functional, and gross with a complex pathophysiology, TBI encompasses Fatima Nasrallah.2015 laboratoryFatima members: result of traffic accidents, injuries, sports or violence. nal force traumatically injures the brain, often as a physiological changes following the initial impact. impact. initial the following changes physiological Recent studies have shown TBI to be associated associated be to TBI shown have studies Recent key protein aggregates, which incidentally also play left hippocampalCA3, andrighthippocampalCA3. Resting-state functional correlation maps in the rat brain show extensive connectivity enhancement following following enhancement connectivity extensive show brainrat the in maps correlation functional Resting-state Image: - state functional connectivity networks in networks connectivity functional state state networks following a cognitive task in cially resting state functional MRI (rsfMRI), MRI functional state resting cially was also the first to detect such resting such detect to first the also was extensive experience in the application of application the in experience extensive She was able to demonstrate, for the first the for demonstrate,to able was She rodents andhumans. positron emission tomography and electro physiology, to understand brain function in function brainphysiology, understand to Previously, Dr Nasrallah has demonstratedPreviously, has Nasrallah Dr magnetic resonance imaging (MRI), espe (MRI), imaging resonance magnetic multimodality imaging methods suchas the mouse brain.the mouse She rodentbrainrsfMRI. sedated the using time, the potential to detect changing resting Laboratory head - - The scope of the research will include: (1) devel (1) include: will research the of scope The (3) translation of novel imaging tools and biomark (2) development of specific imaging tools and diag and protein biomarkers, giving insight into the into insight giving biomarkers, protein and mechanisms fundamental the comprehend and aims to harness multimodality methods to identify changesthebrainin attemptin anto cross-link opment and validation of animal models of TBI, of models animal of validation and opment ers to clinicalinvestigations. of structural, functional, metabolic and molecular molecular structural,and of metabolic functional, nostic molecular biomarkers of TBI and dementia, and pathophysiology of TBI and its link to dementia. to link its and TBI of pathophysiology laboratory her 2015, late in QBI to moved Having imaging metrics with behavioural measures behavioural with metrics imaging triggered following TBI. This will allow mapping allow will This TBI. following triggered r at a r a ralla Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR S ROUP - - -
Research groups Research groups As Director of Flow Cytometry for both QBI and Laboratory head studied to identifythosethat may holdprognostic ordiagnosticsignificance. QBI ANNUAL REPORT 2015 Flow cytometry as akeyFlow tool cytometry research in brain cancer addition, the laboratory is involved in brain cancer ated solid tissue, blood and cultured cell lines. In across the University. The laboratory specialises ysis services to researchers both within QBI and One area in which flow cytometry can be applied from mixed populations. Increasingly, this is being 2015 laboratory2015 members T–B:Nink. Virginia Osborne, Geoffrey research development. andinstrumentation Nanotechnology, Mr Geoffrey Osborne leads a leads Nanotechnology,Osborne Geoffrey Mr in analysing and separating cells from dissoci from cells separatingand analysing in is selecting and isolating single cells of interest team that provides crucial cell and sorting anal and Bioengineering for AustralianInstitute the Mr Geoffrey Mr Osborne - - Cytometry Part A Cytometry flow cytometers use as the basis of single-cell of basis the as use cytometers flow sorting, and sorting, invented a novel solution to address within a population for characteristics of inter of characteristics for population a within In 2008 group leader Osborne identified a flawin otherwise otherwise be missed are selected and enriched. would that cells that and possible, now is est PCR and other molecular biology applications. biology applications. PCR andothermolecular utilised utilised in single-cell transcriptomics, single-cell that sampling the complete diversity present diversity complete the sampling that the available single-cell sorting algorithms that algorithms sorting availablesingle-cell the testing process this method was published in published was method this process testing this problem. Following a long development and Flow cytometric screening of relative microRNA expression levels from tumour sample are sample tumour from levels expression microRNA relative of screening cytometric Flow Image: in 2015. The paper showed paper The 2015. in - “fingerprint” predictive ofpatientsurvival. This has implications for stem cell studies and studies cell stem for implications has This The quantification of microRNAs particular using software implementation of this method was also areas in which cells of interest are infrequent. A a novel flow cytometry assay is another area that assessment of microRNA levels from brain tumour commercialised by UniQuestin2015. ratoryrapidthe allows that method a optimised patient samples that may have prognostic value in this area with the hope developing a microRNA in a clinical relevant time frame. Work continues the laboratory actively pursued in 2015. The labo - sizing to allow the visualisation of up to seven seven to up of visualisation the allow to sizing are using colour coding and differential dot measured parameters in bivariate displays. bivariate in parameters measured Studies of perturbation of the cell cycle cycle cell the of perturbation of Studies
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30k Laboratory head Mr Geoffrey Mr Osborne Expression ofExpression the immature neuronal marker DCX in the the in DCX marker neuronal postnatal hippocampus.
Themature neuronal and glialcells that populate Molecular control of stem neural cell differentiation stem cells. These stemcellsare predominantly and temporally appropriate fashion to produceto fashion temporallyappropriate and and memory. Understanding how neural stem neural how memory. Understanding and found within the embryonic brain, and they must cell differentiation is controlled is critical if we if critical is controlled is differentiation cell our brains are all ultimately derived from neural of new neurons in the adult brain has been has brain adult the in neurons new of Oressia Zalucki. 2015 laboratory membersL–R/T–B:Vidovic, Diana Piper,Fraser,Reid, Michael James Chantelle TraceyIyer,Harris, Oishi, Swati Lachlan Harvey,Sabrina Horne, Elise neurogenesis throughout life. The productionlife. The throughout neurogenesis proliferate, and then differentiate, in a spatially a in differentiate, then proliferate,and the adult brain, where they provide ongoing provide they where brain, adult the in found also are cells stem Neuralbrain. the the right number, as well as type, of cells within linked to crucial processes suchas learning Image: Expression of neural stemcellmarkers GFAP (green), SOX2 (blue)andKi67 (red) inthepostnatalhippocampus. The Piper laboratory studies the genes that development. Moreover, this research will proMoreover,development.will research this group uses mouse model systems and in vitro in and systems model mouse uses group thebrain. Tothis, adult do the and developing diseases suchasbrain cancer. vide insights into developmental disorders and developmentaldisordersinto insights vide are to understand the normal trajectory of brain controls neural progenitor cell differentiation. cell progenitor neural controls thathierarchy genetic the reveal to and cells, progenitorneural of biology the behind cesses cell culture paradigms to investigate the key pro the in differentiation cell stem neural control Moreover, the Piper laboratory is also applying also is Moreover,laboratory Piper the these findings to investigate disorders such as such disorders investigate to findings these Laboratory head - - The group’s recent work has revealed some of revealedsome group’shas The work recent Cerebral Cortex (Vidovic (Vidovic glioma and medulloblastoma, which are char are which medulloblastoma, and glioma differentiationdevelopingthe in brain, how and velopmental disorder known as hydrocephalusas velopmentaldisorderknown acterised by unrestrained stem cell proliferation. work in the Piper laboratory is aimed at further further at aimed is laboratory Piper the in work elucidating thegenesmediatingneural stemcell misregulation of such genes can culminate in culminate can genes such of misregulation in the postnatal brain isco-ordinated (Heng this process can culminate ina serious neurode the key processes underlying how neurogenesis brain cancer. et al Dr Michael Dr Piper ., , 2015), and how abnormalities in Brain ResearchBrain Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR , 2015). Current 2015). , S ROUP et al ., ., - -
Research groups Research groups Wiring up the developing up Wiring brain The Richards laboratory began a new era of era new a began laboratory Richards The Jonathan Lim, Laura Morcom, Annalisa Paolino, Thomas Pollak, Rodrigo Suárez. Laboratory head QBI ANNUAL REPORT 2015 data data to try to understand the relationship between specific patterns of brain wiring and brain function. and internationally to help identify genes causing generated tractography In this same area, the laboratory was awarded a a awardedlaboratory was the area, same this In collect braincollect neuropsychological and MRIdata data bring will consortium The established. was conference Connections, where called a Cortical examining brain wiring in human subjects. Tosubjects. human in wiring brain examining 2015 laboratory membersL–R/T–B:Kok-SiongKozulin,Eyre,Chen, Edwards,PeterBunt, Sinead Tim LauraGobius, Jens Fenlon, Ilan Almarza, Gonzalo Richards, Linda nicians working on developmental brain disorders for protocols establishing by 2015 in research new international of consortium scientists and cli Elliott Elliott Sherr (University of California, San Francisco) National Institutes of Health grant with Professor together from different laboratories in Australia laboratoriesdifferentin from together human brain disorders. will The also consortium launch this, the laboratory hosted an international . ro e or n a R ar - Cairns, and a trainee professional developmentprofessional trainee a and Cairns, in Meeting Satellite 2015 ISN-APSN-ANS the at and investigate theirfunction. and Medical Research Council grant with Professor and and Professor Bill Dobyns (Seattle University, Wash callosum agenesis”. Sherr and QBI researcher Associate Professor Tom received first prize for the best oral presentation neurologists and geneticists, and a National Health Developmental Biology Meeting: “Utilising mouse Best StudentPoster Celland atthe2015Brisbane awards of number a won members Laboratory Burne. Burne. These grants will specifically identify genes models to study altered brain wiring in corpus in wiring brainaltered study to models in 2015. MD/PhD student Timothy Edwards won ington) who are internationally leading paediatric that cause human developmental brain disorders, PhD student Laura Fenlon Image: Human brain tracts identified using magnetic resonance imaging and computer- - Australian Postgraduate Research Award. ($592,700), as well as the Rebecca Cooper Rebecca the as well as ($592,700), de Cure Foundation. grant for his work on brain cancer from the Tour award ($3000) from the American Society for Neu awarded an International Postgraduate Research cil Discovery Early Career Researcher AwardResearcher Career Early Discovery cil Scholarship and UQ Centennial Scholarship, and Senior postdoctoral fellow Dr Rodrigo Suárez was new four-year Australian Research Council grant roscience (SfN). PhD student Jonathan Lim was Dr Suárez and Professor Richards also received a Medical Research Foundation Award ($22,000). postdoctoral fellow Dr Jens Bunt was awarded a Laurastudent PhD Morcom awardedwas full a to study brain development in marsupials. Senior the recipient of an Australian Research Coun ResearchAustralian an of recipient the - -
targets intargets the opposite hemisphere. their reach to brain the of midline the Neurons send projections across
Laboratory head ro e or n a R ar very fine details of their morphology morphology their of details fine very Golgi staining of neurons reveals and allows connections between individual cells to be resolved.
The Sahlaboratory electrophysiology uses and Yajie Sun,Fabrice Turpin, François Windels,Alan Woodruff, LiXu, ShanzhiYan. Notpictured: SamuelHunt, Alex Vourvoukelis. eural r u tr an e an un erp nn n learn n r u tr an eural e or group is mapping the circuits that providecircuitsthat audi the mapping groupis and the properties of these connections. Theconnections. these of properties the and fearcalledparadigm Pavlovianlearning a and conditioning. The group uses viruses to deliver to viruses uses group The conditioning. optogenetic constructs to neurons in defined in neurons to constructs optogenetic amygdala, the called brain the of part the on 2015 laboratory members L–R/T–B: Pankaj Sah, Eleanora Autuori, Suzanne Campbell, Christine Dixon, Arezoo Fallah, Amu Faiz, Andrea Giorni , Helen Gooch, Rebecca Harvey, Using animal models, the laboratory focusseslaboratory the models, animal Using regions, and then records the electrical activity electrical the records then and regions, ioural studies, to understand the neural circuitry molecular techniques, in conjunction with behav in acute brainin acute slicesto studytheneural circuits tory and noxious information to the amygdala, the to information noxious and tory that underpins learning and memory formation. Sarah Hunt, Roger Marek, John Morris, Chris Nolan, Madhusoothanan Bhagavathi Perumal, Margreet Ridder, Petra Sedlak, Peter Stratton, Cornelia Strobel, Robert Sullivan, - - (GABA) receptors that contain γ1 subunits. These dala. In the last year this work has concentrated amygdala and could be targets for the developthe targetsfor be could amygdalaand and isin interested inthe circuits that connect In collaboration with Professor Joe Lynch at QBI, on the properties of synaptic γ-aminobutyric synaptic of properties the on receptors are enriched in specific circuits in the receptors at inhibitory connections inthe amyg ment of new anxiolytic drugs. ofnewanxiolytic ment understand the role of these circuits in behaviour. the group is exploring the molecular identity of identity molecular the exploring is group the and cortex prefrontal the with amygdala the hippocampus. hippocampus. This information is then used to Laboratory head - - Tourette syndrome. In 2016, the group will be will group the 2016, TouretteIn syndrome. The animalstudiesareby complemented elec as Parkinson’s disease, essential tremor and tremorParkinson’s essential as disease, obsessive compulsive disorder. recordings are revealing the activity in the human neurosurgery for deep brain stimulation. These Neuromodulation (APCN), to study neural activ Professor Peter Silburn and Dr Terry Coyne who involved in a clinical trial for the treatment of treatment the for trial clinical a in involved ity in the human brain human the in ity undergoing patients in trophysiological recordings humans in together of arethe Asia–Pacificpart Centre for with collaborates Sah Professor studies, these brain in a range of movement disorders, such disorders, movement of range a in brain Professor Pankaj Sah Sah Professor Pankaj Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR S ROUP . For For - -
Research groups Research groups uall u e t n an al a r ra t an un anne Laboratory head flying organisms continually face the challenge QBI ANNUAL REPORT 2015 display random choices, while other individuals guidance ofaircraft. the for systems inspired biologically design to and navigation, enables and flight guides animals as models to understand how vision how understand to models as animals capacities, despite their diminutive brains.The diminutive their despite capacities, which they can fly to reach a food source. When offering by routes alternative between choose When navigating through cluttered environments, of selecting safe, collision-free routes. Studies routes. collision-free safe, selecting of Srinivasan Biorobotics laboratory is using these Mandyam Srinivasan, Julia Groening, Debajyoti Karmaker, Michael Knight, Kiaran Lawson, Ingo Schiffner, Dean Soccol, Schiffner,Dean Ingo Lawson, Kiaran Knight, Karmaker,Michael Debajyoti Groening, 2015 laboratoryJulia members L–R/T–B:Srinivasan, Mandyam Birds and bees display remarkable navigational the apertures are equally wide, some individuals through apertures two between choice a them to ametal rod environment. so that itcannavigate through avirtual Reuben Strydom, Hong Vo, Mahadeesh Yadav, Michael Wilson. have been conducted to investigate how bees how investigate to conducted been have Professor Mandyam Srinivasan display a clear left- or right-bias, depending upon avert mid-air collisions inaircraft. mid-air collisions avert avoidance of mid-air collisions. High-speed video efficiently move to use might bees of swarm a footage of budgerigars flying past each other is In another study, conducted in collaboration with University of Technology (QUT), the lab is inves providing information about the guidance laws guidance the providing about information thatstrategies the into insights novelprovide Boeing Defence Australia and the Queensland the Australiaand Defence Boeing individually varying “handedness”. They also They “handedness”. varying individually that could potentially be applied to applied be potentially could that automatically tigating biologically inspired strategies for the for strategiesinspired biologically tigating through foliage. dense the first time, that even insects can demonstrate for demonstrate, findings These individual. the Not pictured: Peter Anderson, Aymeric Denuelle. Image: A Queensland fruit fly (Bactrocera ) istethered tryoni - This research is funded by three ongoing research developed has laboratory Biorobotics The grants: (1) an ARC Discovery grant, in collabo in grant, Discovery ARC an (1) grants: objects, moving of interception and pursuit (3) and objects; airborne moving of detection (2) algorithms for (1) visually guided long-rangeguided visually (1) for algorithms navigation, based on honeybee navigation; honeybee on based navigation, ration with QUT,oftracking with rationthe investigate to Boeing, to investigate mid-air collision avoidance andQUT with collaboration in grant, Linkage Researcher Award to study the perception of pain movingtargetsARC byaggressive an (2) bees; in invertebrates. in birds; and (3) an ARC Discovery Outstanding based on the group’s studies of aggressive bees. -
A honeybee feeds from a sucrose feeder feeder asucrose from feeds A honeybee located in a chequered flight tunnel. flight achequered in located
Staining of synapses in “ring neurons” of the fly brain, which are thought to to thought are which brain, fly the of regulate selective attention and and regulate selective attention other cognitive processes.
The van Swinderen laboratory uses the uses laboratory Swinderen van The Aoife Larkin,JamesSteeves, Michael Troup, MatthewVan DePoll, MelvynYap. Image:A tethered flywalksonatrackball controlling anobjectonadigitaldisplay. fly brain. To pay attention, learn, and sleep, and learn, brain. attention, fly pay To such as selective attention, memory,gen attention, selective as such a brain must be able to suppress parts of parts suppress to able be must brain a a central question of the laboratory,a the with of question central a fruit fly model fly fruit with high-throughput behavioural assays and combining powerful molecular genetic tools focus onvisualsystems. focus eral anaesthesia, and sleep in the simpler the in sleep and anaesthesia, eral electrophysiology, the group is able to study 2015 laboratory members L–R/T–B: Bruno van Swinderen, Kathy Asmussen, Adekunle Bademosi, Lachlan Ferguson, Grabowska,Martyna Rhiannon Jeans, Leonie Kirszenblat, investigate perception and cognition. By cognition. and perception investigate the outside world effectively. Understanding phenomena complex of underpinnings the Drosophila how this suppression mechanism works is works mechanism suppression this how Drosophila melanogaster behaviour and cognition Laboratory head to to - Although sleepandattention mightseem done in collaboration with colleagues from colleagues with collaboration in done guides several projects in the lab, was lab, the in projects several guides very different to us, it is possible that both that possible is it us, to different very anisms in the brain. This hypothesis, which hypothesis, brain. This the in anisms found that artificially induced sleep is able is sleep induced artificially that found Biology Neurosciences published as an opinionpiece in phenomena involve similar plasticity mech plasticity similar involve phenomena ila in theflybrain. to restore behavioural plasticity to plasticity restorebehaviouralto Louis) University,St (Washington USA the how sleep and attention regulate each other each regulate attention and sleep how learning mutants (published in in (published mutants learning ). The lab is currently investigating currently is lab The ). Associate Professor Bruno van Swinderen Associate Professor van Swinderen Bruno . In relation to this, recent work Trends in Drosoph- Current -
To the in attention-like understand mechanisms better adigms, published in published adigms, several novel paradigms that allow brainrecordingsallow severalparadigmsthat novel compared to when flies are not in control. This has control. This in not are flies when to compared brain, fly the across coherence increases control Neuroscience Biology reality. The group is now also able to record fromrecord to able also now is reality.group The pay attention, and how sleep may be necessary to necessary be may sleep how and attention, pay multiple multiple channels across the flybrain inthese behav maintain optimal attention mechanisms. optimal attention maintain important important implications for understanding how brains ioural paradigms. In work published in in walking flies as they make decisions. These par These decisions. make they as flies walking in brain, the van Swinderen laboratory has developedhaslaboratory Swinderen van the brain, , allow tracking of visual choices in virtual virtual in choices visual of tracking allow , this year, the group found that active that found year,group this the The Journal ofExperimental Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR The Journal of The Journal of S ROUP - -
Research groups Research groups The Visscher laboratory, within the Centre for Neu Applications are diverse but include the study of Statistics ofStatistics genomes applied to traits and common diseases Laboratory head QBI ANNUAL REPORT 2015 genomics, genomics, a key first challenge is understanding aimed aimed at understanding the genetic basis of dif Gerhard Moser, Joseph Powell, Matthew Robinson, Philip Robinson, Sonia Shah, Konstantin Shakhbazov, Peter Smartt, Costanza Vallerga.Costanza Shakhbazov, Konstantin Shah,Smartt, PeterSonia Robinson, Philip Robinson, MatthewMoser, GerhardPowell, Joseph and advanced statistical analysis. Key outputs Key analysis. statistical advanced and cognition, cognitive change, and psychiatric and ferences in risk for disease, and other phenotypes and epigeneticdataforprediction. 2015 laboratory2015 membersL–R/T–B: Peter Visscher, Marie-Jo Brion, Guo-Bo Chen, Anita Goldinger, Alexander Holloway, Irfahan Kassam, Luke Lloyd-Jones, Allan McRae, neurological disorders. In the era of big data in data big eraof the In disorders.neurological rogenetics and Statistical Genomics, specialises uses theoretical derivations, simulation studies ics, population genetics and human genetics. human and genetics population ics, in developing methodology that enables analyses the questions that the data can deliver. The group boundaries of quantitative and statistical genet between individuals. This research crosses the Professor Peter Visscher - - - 2015), a unified framework for understanding for framework unified a 2015), Goddard, 2015) and a suite of papers on epige on papers of suite a and 2015) Goddard, sampling variances of genetic data (Visscher & & variancessampling (Visscher data genetic of associated withcognitive andphysicalageing. and software tools. from the Visscher lab are new methodologies new are lab Visscher the from odologies for disease risk prediction (Moser neticassociations measurable bloodthatarein netic epidemiology, led by postdoctoral researcher Lothian Birth Cohorts anddemonstrating epige Cohorts Lothian Birth (UniversityEdinburgh), of the Deary on working Dr Riccardo Marioni, who splits his time between Research highlights of 2015 include new meth new include 2015 of highlights Research the Visscher lab and the lab of Professor Ian Professor of lab the and lab Visscher the et al. - - - , The Visscher group’s research often uses model data (Shah genetic effects can together lead to differences sizes to demonstrate proof of principle. For principle. of proof demonstrate to sizes study of Parkinson’scollab of in study initiated disease, and selection (Robinson complex traits, such as height and body mass body and height as such traits, complex example, the group published predictors of a of predictors published group the example, oration with Professor George Mellick (Griffith Mellick GeorgeProfessor with oration extensive experience in epigenetics led to a new University) and Dr Toni Pitcher (New Zealand (New ToniDr Pitcher and University) phenotype from both genetic and epigenetic and genetic both from phenotype Brain Research Institute). index, that are available on the largest sample largest the on available are that index, between between populations, differentiating between drift
Adjusted - R² Adjusted - R² 0.00 0.00 0.20 0.20 0.05 0.05 0.10 0.10 0.15 0.15 et al. , 2015) and demonstrated how LBCs Prediction cohort Prediction Combining genetic Image: Combining genetic et al. Height BMI , 2015). The group’s × methylation score score + genetic methylation score genetic score methylation score Model genetic score LifeLines - A new statistical tool for deciphering deciphering for tool statistical A new the genetic architecture of diseases. of architecture genetic the
Variance explained (%) 100 Variance explained (%) 100 50 50 25 25 75 75 0 0 diabetes diabetes type II type type I type 10 10 10 mixture component –2 –3 – 4 × × × hypertension rheumatoid g g g arthritis ² ² ²
disorder disease bipolar heart Laboratory head Professor Peter Visscher Dendro-dendritic contacts (purple) contacts Dendro-dendritic (blue) and an interneuron (red). between a retinal ganglion cell cell ganglion aretinal between 100 µm
The algorithmsunderlyingbrain computations The grey area showsthesynapticoutputzone. eural r u t o putat on r u t eural are embedded in the connectivity of neuronal of connectivity the in embedded are operations of component synapses and neu and synapses component of operations 2015 laboratory2015 membersL–R/T–B: Stephen Williams, Arne Brombas, Florence Cotel, Lee Fletcher, Simon Kalita-de Croft. networks, and implemented by the functional the by implemented and networks, rons. The Williams laboratory is investigating is laboratory Williams rons.The use advanced electrophysiological and optical and electrophysiological advanced use implemented in the central nervous system. They ically engaged computations in theretinal in computations ically engaged and techniques to mechanistically dissect physiolog how neuronal circuit-based computations are computations circuit-based neuronal how - - fine-scale interplay between network connectivity and sub-cellular information processing lies at lies processing information sub-cellular and Ongoing work in the laboratory is aimed at discov ering the circuit elements that drive and control neurons, a finding that demonstrates that the that demonstrates that finding a neurons, revealed that neuronal circuit computations occur neocortical micro-circuitry. Pioneering work has physiologically engaged dendritic information dendritic engaged physiologically in the fine tree-like dendritic arbours of central of arbours dendritic tree-like fine the in the heart ofbrain computations. the heart Laboratory head Professor Stephen Williams Williams Stephen Professor - strongly modulated by the cholinergic system, cholinergic the by modulated strongly attentional attentional processing. Furthermore, in the retina co-release of neurotransmitters from interneu neurotransmittersfrom of co-release rons on the control of network computations, network of control the on rons processing. For example, the group’s recent work providing a plausible candidate mechanism for in order to better understand visual processing. tion in the output neurons of the neocortex is neocortex the of neurons output the in tion they are dissecting the functional impact of the has demonstrated that active dendritic integra dendritic active that demonstrated has Image: Confocal image of a retinal interneuron. Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR S ROUP - -
Research groups Research groups The Wray lab co-authored over 20 publications in The Wray laboratory, within the Centre for Neuro Laboratory head Genetics and epigenetics of psychiatric and neurological disorders 2015, leading work on diverse topics from stroke QBI ANNUAL REPORT 2015 (Marioni (Marioni genetics (Holliday direction of the lab is systems genomics epide genomics systems is lab the directionof diagnosis, prognosis and treatments. A key new genomic data to provide insights into these com- genetics and Statistical Genomics, focusses on variants inlarge samples. specialises in applying new analytical methods of chiatric and neurological and chiatric disorders 2015 laboratory membersL–R/T–B: Naomi Wray, Earlene Ashton, Beben Benyamin, Enda Byrne, Jake Gratten, Anjali Henders, Zhijun Liu, Maier,Robert Divya Mehta, Natalie plex plex disorders, with an ultimate goal to improve understanding the genetic contribution to contribution genetic the psy understanding miology, the study code of and DNA epigenetic tion of epigenetic ageing with all-cause mortality Mills, Jennifer Pavlides, Wouter Peyrot, Restuadi Restuadi, Maciej Trzaskowski, Anna Vinkhuyzen, Hasti Ziaimatin. et al. , , 2015). In Lee et al. , 2015) to the associa the to 2015) , et al. , , 2015, the group ro e or ao ra . The group The - - - - They reported evidence that coding and regula- and coding that evidence reported They American Journal of Human Genetics” papers Genetics” Human of Journal American for theyear. work was listed as one of the seven “Best of the smoking high the despite schizophrenia, with examined the epidemiological conundrum that examined theepidemiologicalconundrum researcher Dr Hong Lee and PhD student Robert researcher Robert HongLee andPhDstudent Dr rates, a major risk factor for rheumatoid arthritis. Maier explored how genetic information shared Major grant success includes an NMHRC Pro NMHRC an includes success grant Major ject Grant and Brain & Behaviour FoundationBehaviour & Brain and Grant ject improve genetic risk prediction of a disorder. The the two disorders. A study led by postdoctoralby led study A disorders. two the tory variants are negatively correlated for risk of the risk of rheumatoid is arthritis lower in those between psychiatric disorders can be used to used be can disorders psychiatric between - QBI Bioinformatics Core: Zong-Hong Zhang, Qiongyi Zhao. Autism Spectrum Disorders; and The Ice Bucket (MND), (MND), awarded by MND Research Institute Aus with Living for Centre) (Co-operativeResearch grant funding means that the group is now estab Challenge Grant for ALS motor neurone disease and genomicanalysis ofhumansamples. ciate ciate Professor Henderson Robert from the Royal clinicians Professor Pamela McCombe and Asso Dr Dr Jake Gratten; a research agreement to estab to awarded both Award, Investigator New Brisbane and Women’s Hospital. tralia. This funding for ALS has resulted in the in resulted has ALS for funding tralia.This human studies manager Ms Anjali Henders, the lish a systems genomics project with the CRC the with project genomics systems a lish lishing a wet laboratory to undertake biobanking lab working very closely with the ALS research ALS the with closely very working lab Facilitated by - - - -
The prediction of The prediction bipolar disorder (red) is enhanced by including data data including by enhanced is (red) from schizophrenia patients (blue). decile compared to lowest 10 1 2 3 4 5 6 7 8 9 0 12 3 45 6 7 odds ratio odds
and caudate nucleus, and replication of findings findings of replication and nucleus, caudate and Novel genetic variants influencing the putamen putamen the influencing variants genetic Novel for hippocampal and intracranial volume.
The Wright laboratory, within the Centre for Neu Understanding brain function and diseaseUnderstanding using imaging and genetics and size of brain structures, brain wiring and wiring brain structures, brain of size and and and genetic information has been collected from are used, and a vast dataset of imaging, clinical, connectivity.differ understand toare Key aims on the neurobiological causes and modifiers of ences in the healthy brain, to provide insightsprovide to brain, healthy the in ences 2015 laboratory members L–R/T–B:Strike. Lachlan Hwang, Daniel Hansell, Narelle Couvy-Duchesne, Baptiste Wright,Margie rogenetics and Statistical Genomics, focusses Genomics, Statistical and rogenetics people at different ages. The group investigates and tests, neuropsychological imaging, Brain into deviations from normal development anddevelopment normal from deviations into to differences between individuals in the shape the genetic and environmental factors that lead the whitemattermicrostructure ofthebrain. behavioural and molecular genetic approaches disorders.brain especially and function, brain Laboratory head - - A highlight in 2015 was the collaborativework the was 2015 in highlight A findings for variants influencing hippocampal influencing variants for findings differences in the volumes of the putamen and subcortical brain volumes, including genome- including volumes,brain subcortical and intracranial volume were confirmed. In confirmed. were volume intracranial and ageing, ageing, and to increase the understanding of the with the ENIGMA consortium, in which the which in consortium, ENIGMA the with for psychiatric andage-related brain disorders. caudate nucleus were identified, and earlier and identified, were nucleus caudate was performed (Hibar (Hibar performed was wide scans and MRI scans from 30,717 people, other collaborative work including data fromdata including workcollaborative other Five novel genetic variants associated with associated variants genetic novel Five biological processes at the core of illness risk illness of core the at processes biological largest genome-wide association study of study association genome-wide largest Associate Professor Margie Wright et al. , , Nature , 2015). , differences inwhitematter. trackto used is and imaging, tensor diffusion and and environmental factors alter the developmen genetic when periods sensitive particularly are cence. A key aim is to determine whether therekeytowhether A is determine cence. aim cal Research Council will enable the group to track of white matter microstructure, derived fromderived microstructure, matter white of (FA).anisotropyfractional on FAmeasure a is New funding from the National Health and Medi made in understanding the genetic influence genetic the understanding in made mental illness. Adolescence is a risk period for period risk a is Adolescence illness. mental the Human Connectome Project, progress was the emergence ofpsychiatric disorders. tal trajectory in adolescence, and mediate risk for the dynamic changes inthe brain through adoles Genetic influence (heritability) on on (heritability) influence Genetic Image: Queensland Brain Institute S E R Annual Report 2015 Annual Report CH G CH EAR S ROUP - - -
Research groups Research groups The Yang laboratory, within the Centre for Neu Yangfor laboratory,CentreThe the within Laboratory head Genetics and genomics of human complex traits can becaptured by imputationregardless ofthetypesSNParrays used. QBI ANNUAL REPORT 2015 genetic genetic architecture of complex traits in humans, genetic and genomic data to understand the and schizophreniaand . with specific interests in model traits such as such traits model in interests specific with forming large-scale analyses of high-throughput computer science. The group’s research focusses complex traits anddiseases. on developing new statistical methods and per 2015 laboratory2015 membersL–R/T–B: Jian Yang, Andrew Bakshi, Yang Wu, Futao Zhang, Zhihong Zhu. rogenetics and Statistical Genomics, works on works Genomics, Statistical and rogenetics number of citations, the methods and software used in the research community for a range of range a for community research the in used the interplay of genetics, genomics, statistics and toolsgroupdevelopedhavewidely the by been height, and common diseases such as obesity as such diseases common and height, As demonstrated As by the Associate Professor Jian Yang Imputation accuracy (IMPUTE-INFO) threshold (IMPUTE-INFO) accuracy Imputation - - Proportion of variation captured 0.0 0.2 0.4 0.6 0.8 1.0 The importance of dominance variation to com Genetics dominance dominance variance is only one fifth of additive et al. et variance, which is too small to be important to could be an important source of missing herita nucleotide polymorphisms (SNPs) data (Zhu data (SNPs) polymorphisms nucleotide plex trait variation is a long-standing question long-standing a traitis variationplex unrelated individuals using genome-wide single in the field of human genetics. Recently, it has the missingheritability that is able to estimate dominance variation in bility. The Yang group proposed a novel method variationdominance that hypothesized been large data sets that, on average across all traits, 0 , 2015, The The 2015, , 0.1 ). They demonstrated by analyses of analyses bydemonstrated They).
0.2 0.2 0.3 0.3 American Journal of Human of Journal American
0.4 0.4 . 0.5 0.5 0.6 0.6 0.7 0.7 0.8 0.8 Image: A large proportion of variation at sequence polymorphisms 0.9 - - The group also proposed a novel method to method novel a proposed also group The The Yang laboratory was successful in grant in successful was laboratoryYang The They further showed that the missing heritability grant (CIA). sequencing data (Yang sequencing sequencing for gene discovery at current prices. study design with SNP arrays followed by impu as CIA and one as CIB) and one NHMRC project awarded two ARC discovery project grants (one funding in 2015, with Associate Professor Yang estimate heritability for human complex traitscomplex human for heritability estimate in unrelated individuals, using whole-genome using individuals, unrelated in ics is negligibleforheightandbodymass index. tation tation is more cost-effective than whole-genome ). They showed by intensive simulations that a Rare - Illumina CoreExome -Illumina Rare Omni2.5 -Illumina Rare Rare - OmniExpress Illumina Axoim -Affymetrix Rare 6 -Affymetrix Rare Common - Illumina CoreExome Omni2.5 -Illumina Common - OmniExpress Illumina Common Axoim -Affymetrix Common 6 -Affymetrix Common et al. , 2015, Nature Genet- - all common SNPs for 79 human complex traits. complex human 79 for SNPs common all dominance (blue) variance captured by Distribution of additiveDistribution (pink) and
estimates of hSNP² or δSNP² 0.4 0.2 0.0 0 510 h ² SNP frequency δ
15 SNP ² Laboratory head Associate Professor Jian Yang this pair of ASH chemosensory neurons, used to understand understand to used neurons, chemosensory ASH of pair this living individuals of the model organism C. elegans— organism model the of individuals living Cell-specific promoters allow neurons to be visualised in in visualised be to neurons allow promoters Cell-specific molecular mechanisms of mechanisms molecular damage. mitochondrial such as as such To sustain correct function, terminally differ terminally function, correct sustainTo Although direct links between these factors and dysfunction, and toxicity resulting from confor from resulting toxicity and dysfunction, Epigenetics and mitochondrial biology survivability in neuron are associated with practically every single age- an enormous disease burden on individuals, fam (red–yellow) inthenucleusofcellsC.elegans.Cellularplasmamembranes are labelledyellow–purple. world, neurodegenerative disorders representneurodegenerativedisorders world, With life expectancies increasing around the around increasing expectancies life With entiated post-mitotic neurons must preserve must neurons post-mitotic entiated 2015 laboratory members L–R/T–B:AndreaTweedie. Ahier,Dai, YangArnaud (Michael) Chuan Zuryn, Steven related neurodegenerative disease: mitochondrial mationally challenged, aggregate-prone proteins. individual neuron over function time. ilies, and society. Two forms of cellular stress cellular society.of and Two forms ilies, that such stressesthat such ultimatelyleadto adeclinein their subtype identity, subtype their morphology, activity, and human human disease are sometimes elusive, it is clear - - -
gate disease-related threats. The beauty of such single-cell andsingle-generesolution. a modelisthatthey are ableto accurately distil correct cell function. They have recently found recently have Theyfunction. cell correct focuses of the Zuryn group is the emerging role In 2015 Dr Zuryn was awarded the Stafford Fox complex phenotypic phenomena down into down phenomena phenotypic complex miti to use neurons mechanisms fundamental connectivity even in the presence of these chronic of epigenetic mechanisms that help preserve help that mechanisms epigenetic of Senior Research Fellowship and opened his opened and Fellowship Research Senior new lab at QBI in September. One of the main the September.of in One QBI at lab new ular genetic techniques in the highly successful model organism insults. molec cutting-edge labuses The Zuryn C. elegans to understandthe Laboratory head - -
The Zuryn group isalso interested inunder developed novel genetic tools in 2015 that will that 2015 in tools genetic noveldeveloped standing fundamental aspects of neuronal of aspects fundamental standing stresses thatmodelstroke anddementia . They aim to develop means to protect robust neuronal under responsesneuronal probe to them allow conditions, research that was published in the in published was that research conditions, criteria criteria that may influence disease progression. function fromfunction these typesofdiseases. robust neuronal function in the face of stressful prestigious journal mitochondrial biology. To do this, they have they this, biology.do Tomitochondrial is to understand how this occurs, and to be able that specific types of histone methylation ensure to predict outcomes under alternative epigenetic Expression of the epigenetic enzyme Jmjd3 enzyme epigenetic the of Expression Image: r te en r ur n Queensland Brain Institute Science S E R Annual Report 2015 Annual Report . The team’s goal next CH G CH EAR S ROUP -
Research groups Centres and facilities QBI ANNUAL REPORT 2015 Inside the Brain Queensland Institute. Centres and facilities to cutting-edge facilities, some of which are the Our research is only possible by having access QBI is home to dedicated research centres learns and ages and learns genetics of brain disorders, to the way the brain in important fields of neuroscience, from the best of their kind in the world. . CENTRES Queensland Brain Institute Annual Report 2015 Annual Report AND F C A ILITIES
Centres and facilities Centres and facilities Clem Jones forClem Centre Ageing Dementia Research QBI ANNUAL REPORT 2015 The Centre, headedby Professor Jürgen Götz, THE CLEM JONES five years as a commitment to accelerate the accelerate to commitment a as years five ease mechanisms and preventingand ease mechanisms treatingand 201 a a a or re ear entre t n t n entre re ear a or a a 201 e ent a u a Al e er ea e research towards a cure for dementia, with addi Federal Government awarded $18 million for million $18 awarded GovernmentFederal the and Government Queensland the Both Foundation, The John T.John Foundation,The and Foundation Reid the Yulgilbar Foundation. The research doneat tional funding being provided by the Clem Jones Research (CJCADR) wasopened inFebruary is focussed onresearch focussed is into discovering dis Ageing Dementia Centre for Ageing Dementia - - son, son, Götz, Hu, Hilliard and Meunier laboratories and systems level, how ageing dementia causes molecular,biochemical, a at explores, CJCADR conduct dementia-related research at CJCADR neurodegeneration, decline of memory and of and memory of neurodegeneration,decline researchers. Professor Götz said that the Centre was very for Researchers from the Anggono, Bartlett, Coul Bartlett, Anggono, the from Researchers During 2015the Centre continued a recruit motor functions. ment programment to attract international additional joined asaGroupLeader inMay 2015. tunate that Dr Zhitao Hu from Harvard University behavioural, electrophysiological, histologicalelectrophysiological, behavioural, . - - - “In addition, Dr Patricio Opazo from the Bon- the from Opazo Patricio Dr addition, “In “A major outcome is the discovery of therapeutic
There was a media storm surrounding the the surroundingstormAbove media a left: was There diagnose dementia earlier, more cheaply andearlier, cheaply dementia more diagnose visit of the Queensland Premier, Annastacia Queensland Hon the The of visit will also be formulated for maintaining a healthy cognitive decline.” with higher sensitivity and specificity and to mon for Alzheimer’s disease treatment by CJCADR Director itor therapeutic interventions. Lifestyle strategies Professor Jürgen Götz (right) and Gerhard Leinenga (left). breakthrough a announce to (centre), MP Palaszczuk brain, in particular how exercise slows down slows exercise how particular in brain, The Centre will continue to work towards reduc sound to removetoand toxicaggregates proteinsound for the University of California, Irvine will join will Irvine California, of University the for was published in early 2015 and is currently is and 2015 early in published was outcome is the developmentbiomarkerstothe of is outcome restore memory functions. This novel strategynovel This functions. restorememory research output.” recruitments will have synergistic effects on our Neurobiology in Munich and Dr Rodrigo Medeiros us at the beginning of 2016,” he said. “These2016,” said. of he beginning the at us using using novel drugs and better methods to deliver novel pursuing by dementia of burden the ing interventions interventions to delay the onset of dementia and treatment strategies, including the use of ultraof treatment strategies,use the - including them to the brain,” Professor Götz said. “Another toprevent evenand cure patients,in dementia hoeffer laboratory at the Max Planck Institute of being explored foritstranslational potential. - - Genomics Imaging Genomics Cognitive Ageing Complex Trait Genomics Genomics Systems Motor Neuron Genomics Disease Psychiatric Genomics The CNSG was established to bring together a together bring to established was CNSG The Associate ProfessorAssociate Margie Wright the became grant sixfellowships. fundingincluding genomics, bioinformatics and computational and bioinformatics genomics, statistical genetics, neuropsychiatric genetics, are quantitative measures, diseases or disorders focussed focussed labs at QBI. The Centre comprises more of the with themes, the which coreall interface Senior researchers within the CNSG lead each lead CNSG the within researchers Senior eno o re te a ult o re te eno entre or euro enet an tat t al an euro enet or entre 2015MARKED THE team of researchers with expertise in neuro in expertise with researchers of team imaging, providing an important link between link important an providing imaging, is at the interface of genetics, cognition and brain that are underpinnedby multiple geneticand theme of complex trait genomics. Complex traits than 30 staff who are all funded by competitive the genetic focus of CNSG with other imaging- other with CNSG of focus genetic the fourth QBIFaculty member,fourth joiningAssociate biology.Wright’sProfessor Associate research ro e or eter er an ao ra ao an er eter ro e or ro e or an an second year for the entre or entre euro enet an tat t al eno -
ders, as well as the CNS disorders studied in the and immune disor diseases suchascancers grants (led by Visscher, Yang and Robinson),Visscher, Yangandby (led grants ageing and imaging genomics are genomics imaging and ageing phenotype Centre. The themes of psychiatric, MND, cognitive a Brain & Behaviour Foundation New Investiga an NIH sub-award (Wray). This year Human year This (Wray). sub-award NIH an In 2015 CNSG was awarded grants totallinggrants awarded was CNSG 2015 In focusses on epigenetic and expression epidemi with Autism Spectrum Disorders (Gratten) and with the Co-operative Research Centre for Living contract(Wray),Granta Challenge Bucket Ice collaborations now underway.May,now collaborationsCNSGIn a ology. CNSG hosts the QBI Bioinformatics core, Studies Manager Anjali Henders established a established Henders Anjali Manager Studies non-genetic factors. These include common include These factors. non-genetic ples necessary forthelargeples necessary numberofclinical more than $5 million: three ARC discovery ARC three million: $5 than more to receive and process human biological sam biological human process and receive to tor Award (Gratten), the Motor Neurone Disease two NHMRC project grants (Yang and Gratten), human studies unit for QBI, allowing the Institute based, while the theme of systems genomics systems of theme the while based, led by DrQiong-YiZhao. - - - - The CNSG team, which in 2015 expanded to expanded 2015 in which team, CNSG Above:The Genetics (Visscher, Mt Sinai School of Medicine Inaugu Medicine of School Sinai (Visscher, Mt growing collaboration. delegation (Visscher, Wray, Yang and Henders) International Journal of Epidemiology of Journal International visited Wenzhou Medical University to a further authors on papers published in top journals in journals top in published papers on authors lead been have who 2015, in members CNSG cited researchers. The reputation of CNSG is CNSG of reputation researchers.The cited ods (Yang, Gordon Research Conference, Italy). meth genomic to Genetics) Human of Society Neuroscience ral Seminar series) to precision medicine (Wray, interna of number large a through recognised President’s Plenary Symposium of the American More than 70 publications were co-authored by four laboratory groups comprising more than 30 staff. topics—from “Genomics, Big Data and Medicine” ofrange wide a on invitations speaking tional the field: listed in the Thompson Reuter’s Index of highly again once was VisscherProfessor lications). Left: The five CNSG research themes. Nature Genetics (2 publications), (2 , American Journal of Human CENTRES Queensland Brain Institute (3 publications), Annual Report 2015 Annual Report AND F Genome Biology C A ILITIES (2 pub (2 Nature Nature - - - - ,
Centres and facilities Researchers from the SLRC shared knowledge of learning and the brain with school students Science of Learning Research Centre as part of UQ's Solid Pathways program.
QBI ANNUAL REPORT 2015 This was extremely well received, with demand and the brain with school students as part ofUQ'sand thebrain withschoolstudentsaspart SolidPathways program. learn”.we how of science “The seminar his for house full attracteda Melbourne) of (University Hattie ProfessorJohn leader theme AboveSLRC centre: seminars seminars across the year, including the American Institutes for Research'sfor Osher’sInstitutes Davidpres - Dr In June, more than 80 teachers from acrossfrom teachers 80 than more June, In for a second follow-up workshop, held in held workshop, follow-up second a for UQ. at held Workshop Development fessional conditions conditions for learning” and Flinders University’s Queensland attended the Centre’s first Pro Centre’sfirst the attended Queensland entation “Socialand emotional learning and the A FOCUS OF THE executive functions and NAPLAN results”.executive andNAPLAN functions engagement, includingaseminarseries,with Centre (SLRC) in2015wasoutreach and not thinking you are just being logical: creativity, Professor Martin Westwell’s“You areseminar Martin Professor sem the off kickededucators, researchersand Professor John Hattie’s seminar, “The science of inar series. This was followed by a further 10 further a by followed was This series. inar t e e u at on o un t how we learn”, which attracted more than 200 than learn”,moreattracted we which how Research Science ofLearning Research - - The Centre is extremely grateful to all the schools (UQ School of Education). The SLRC thanks the Cunnington (QBI) and Professor Robyn Gillies ProfessorRobyn and (QBI) Cunnington a teacher on secondment from Brisbane State October. These workshops were replicated at The was extremely fortunate to benefit from the from benefit to fortunate extremely was Queensland Department of Education for sup for Education of Department Queensland University of Melbourne. Planning for workshops porting thisinitiative. porting relationship the investigating is which project, uting uting to several research projects in the Centre, School. High Research Translation Team,contrib as well as includingthe Teacher-StudentSynchronicity in 2016 is already well underway.Centrewell The already is 2016 in that have supported us throughout the year and tionship in a classroom, led by Professor Ross between students and the student-teacher rela knowledge and experience of Ms Tennille Seary, look forwardto ongoingcollaboration. Ms Seary played MsSeary akey rolein the - - -
The SLRC would like to acknowledge the support of the Australian Research Council and our and Council Research Australian the of support the acknowledge to like would SLRC The C Collaborating and Partner Organisations:Collaborating andPartner • • • • • • • • ollaborating Organisations: The University ofMelbourne Australian Council for Educational Research Curtin University Curtin University Charles Darwin University ofNewEngland Macquarie University Flinders University Deakin University Science ofScience Learning Research Centre Researchers from the SLRC shared knowledge of learning learning of knowledge shared SLRC the fromResearchers Above right: Partner Organisations: Partner • • Questacon • • • • • • • Carnegie MellonUniversity and Training, Queensland and Training, Victoria and ChildDevelopment, SouthAustralia University ofLondon University CollegeLondon Department forEducation Department Benevolent Society Carolina StateUniversity North Department ofEducation Department ofEducation Department CENTRES Queensland Brain Institute Annual Report 2015 Annual Report AND F
C A ILITIES
Centres and facilities Centres and facilities The facility’s capabilities allow 3D imaging of imaging 3D facility’sallow capabilitiesThe Advanced microscopy facility microscopy Advanced to capture, recombining and analysing them is an emerging challenge for neuroscientists. Imaged by Dr Jeremy Ullmann, combined and processed by Luke Hammond. in the brain. Each brain is comprised of 5000 separate image files, with the three brains totalling approximately 100GB of data. While the images only take a few minutes Above right: Neuronal cell bodies within the brain of three separate zebrafish. Imaged using a spinning disk confocal microscope, and coloured depending on the depth microscope. super-resolution a to next Amor Rumelo Dr and (Manager) Hammond Luke Chien, Arthur staff facility microscopy Advanced Above left (L–R): QBI ANNUAL REPORT 2015 structures within neurons. Many of the instru the of Many neurons. within structures In 2014QBIwasawarded $1.2millionthrough of dynamic processes related to neuroscience 24 high-end instruments, it offers it instruments, high-end 24 researchers at ronal survival. research, such as axon regeneration and neu regeneration and axon as such research, QBI access to state-of-the-art technology,QBI access to state-of-the-art lead ments have been designed to allow imaging of the ARCLIEFschemeto establishasuper-resolu tion facility. One of the first of its kind in Australia, or tra n n upport an e per ental a e or tra n n upport QBI’S ADVANCED MICROSCOPY brain tissue all the way down to sub-cellular to down way the all tissue brain ro op a l t e n t e orl u lt aroun live neurons and organisms to facilitate the study ing visualisation software and experienced staff ing visualisation software andexperienced staff is one ofthelargest andmostdiverse light facility - - - - details details such as individual proteins in living cells. similar similar techniques to observe the dynamic rings forming at the surface of cells during neuro during cells of surface the at forming QBI researchers have already published several Molecular Psychiatry Using Using super-resolution microscopy techniques, regeneration.toable use was lab Meunier The neurons, automating the analysis of neuronal of analysis the automating neurons, populations, mapping neuronal processes inprocesses neuronal mapping populations, publications in the the in publications New work within the facility is focussed on focussed is facility the within work New microscopy to observe protein localisation at localisation protein observe to microscopy the plasma membrane of axons during axon during axons of membrane plasma the tracking individual receptors moving within live transmitter release . this facility allows QBI researchers to see minute high-ranking peer-reviewed papers, including papers, peer-reviewedhigh-ranking lab’s publication in Nature Journal ofNeuroscienceJournal and used super-resolution Nature . The Hilliard The - , This technique will allow researchers to map out The facility plans to extend its capabilities into capabilities its extend to plans facility The and and image storage and sharing. The latter allows and create 3D maps of entire neuron populations at sub-cellular resolution at extremely high-speed within thebrain. worked closely with information technology staff processing.intensive computationally without where inthe world. any from data their toresearchers access QBI will allow QBI researchers to image entire brains numbers. Advancements in imaging speed mean For this reason, the microscopy facility has facility microscopy the reason, this For to bring online new servers for image analysis image for servers new online bring to produced data the too is large to beanalysed synapse quantifying and braindeveloping the the the activity of individual neurons in living brains the area of light-sheet imaging, a method that method a imaging, light-sheet of area the . -
Animal house and behavioural suite To answer the exceptionally complex questions Morgan Leigh, Danielle Kendrick, Liesel Macdonald, Danielle Eastley, Kit Yee Leung, Michael Berg and Daniel Blackmore. Daniel and Berg Michael Eastley,YeeLeung, Danielle Kit Macdonald, Liesel Kendrick, Danielle Leigh, Morgan QBI. at researchers the for surgery of Above left: Computerised, motor driven stereotaxic equipment that can be utilised to conduct microsurgery on rodents. This equipment allows for even greater accuracy Michael Lutkins Ashrafi. andMaryam also help with proper colony management, best animal house facility has 12 full-time staff mem with researchers to ensure they get the type of type the get they ensure toresearchers with of genes to create models that mimic the brain a simple areaa simple where are animals bred kept or researchers are asking requires the manipulation understanding of the processes involved.Theprocesses the of understanding model they need for their essential research. Staff in bothadiseasedandhealthystate.Tocreate these animals requires a lot of time, energy and ro ore t an 2 0 enet all o e l ne than 11,000 animals that have animals than 11,000 beenderived bers. bers. These dedicated staff are actively engaged breeding practices and establishment of novel of establishment and practicesbreeding QBI’S ANIMAL HOUSE unt l nee e t e re ear er t ou e ore just moreis much thanjust Some of the dedicated animal house staff: Brodie Quine, Katherine Meyer,Katherine Manager), Quine, (CentreBrodie Trish Hitchcock staff: house animal dedicated the of Some Above right (L–R): - Tissue and blood collection, minor surgical prosurgical minor collection, blood and Tissue genetically modified lines. The facility conducts studies conducted within the Institute and are and Institute the within conducted studies and lightcycle. are cared for to the highest standard. These ani where needed and excellent animal husbandry husbandry animal excellent and needed where with constant monitoring of animals, special diets cedures and training new staff and students in students and staff trainingnew and cedures of experience readily on hand, this is usually the years many so With operations.day-to-day of mals mals are the corner-stone for the majority of the methodologies employedmethodologies to ensure animals all this includes temperature,qualityhumidity, air includes this the facility is designed to ensure consistency and treated with the utmost respect. Every aspect of basic animalhandlingprocedures are alsopart best practice for every aspect of animal welfare Animal house and behavioural suite - - The animalhousealsocontainstheAnimal first place most researchers contact to establish abilities. Twelvetorodentroomsarededicated allows researchers to investigate a large range of for rodent behaviour that allows for translationfor allows that behaviourrodent for outcomes. outcomes. The facility also contains behavioural Many of these are the most up-to-date behav up-to-date most the are these of Many Facility.Surgical BehaviouralFacilityand This paradigms touch-screen utilise that technology more than 40 behavioural tests and procedures. motor function to complex memory and learning in accurate and rapid analysis of behaviouralof analysis rapid and accurate in iouraltracking programs available. resultsThis their experimental modelofchoice. their experimental behaviour, allowing researchers to undertake tobehaviour, researchers allowing behavioural characteristics, ranging from simple between animalandhumanstudies. Kim Woolley,Kim Rachow,Not pictured: Robyn CENTRES Queensland Brain Institute Annual Report 2015 Annual Report AND F C A ILITIES -
Centres and facilities Mentorship QBI ANNUAL REPORT 2015 tour of QBI's Biorobotics laboratory. takes a visiting student group on a a on group student avisiting takes Professor Mandyam Srinivasan
Mentorship The InstituteThe is strongly to committed the mentorship and career development of Honours, Masters and PhD students as well stages of their careers. QBI provides world-class research training as postdoctoral and professional research staff. not only for students, but scientists at all
Queensland Brain Institute Annual Report 2015 Annual Report M ENTOR SHIP
Mentorship Mentorship QBI alumni QBI QBI ANNUAL REPORT 2015 The thing that stays with me most about QBI is QBI about most me with stays that thing The Geoffrey Goodhill’s laboratory had a postdoctoral QBI seemed to be a good match with my inter my with match good a be to seemed QBI opportunity to workatQBI. opportunity ests ests in the close interaction between experimental of Singapore andworked asasystem engineer o puter en neer n at t e at onal n er t en e A ter n e n ele tr al an research labs doing research in a range of areas,range of a research in doing research labs roscience, and a daily routine of discussions and neuroscienceresearch and computationalneu position available and thanks to this I had the had I this to thanks and available position imaging, synaptic function and cognition. QBI has neuraland computation including circuits, neuro its distinct focus on brain research: to understand interactions with neuroscientists. I found Professor Institute, Ihadastrong desire to pursue deep how the brain works through a wide spectrum of research brain science andcomputational neuro po t o toral po t on in STMicroelectronics, searching fora Istarted WHEN I FIRST came to the Queensland Brain - - - - (I²R), and tostarted set up my own research group science in the world and a wonderful organisation brainin name big a brand, solid a is QBI stands. equip and facilities scientific sophisticated very acclaims and awards: we developed an artificial artificial an developed we awards: and acclaims and lab, the Cognitive Computing Group, which was for researchers. QBI equipped me with a good scientific vision, rich exciting research directions. Of course, I also like researcher. After leaving QBI, I returned to Singa to returned I researcher.QBI, leaving After research group has received various international My computing. neuromorphic namely research, pore to join the Institute for Infocomm ResearchInfocomm for Institute the poretojoin ment, ment, and also a robust scientific atmosphere and it came to doing cutting-edge cross-disciplinary ing. My training at QBI was of great benefit when to grow as an independent and aspiring young aspiring and independent an as grow to training in Professor Goodhill’s lab, where I started the first I²R group to focus on brain-based comput the quiet and beautiful St Lucia campus where QBI how the brain works. I appreciated the postdoctoral knowledge and a strong interest in understanding Professor Huajin Tang 2006–2008 - - - 10 years. There is still a long way to go but I am I but go to way long a still is years.There 10 As Confucius says: “What a pleasure to have a have to pleasure a “What says: Confucius As Award in 2016. I have served in various positions Associate Editor of 2015), and Associate Editor of grid cells, which was reported by MITTechnol by reported was which cells, grid quality research” as my objective, and also to lead on Neural Networksand LearningSystems selected by the IEEE Computational Intelligence artificial “GPS” brain cells) as making significant making as cells) brain “GPS” artificial Chengdu, Chengdu, China. Sichuan University is among the friend comefrom afar.” panda. city andhomeofthegiant welcome QBI researchers to Chengdu, a beautiful would I alumnus, QBI a As researchers. QBI with opportunities collaborative exploring to forward University, Sichuan at professor a now am I on Cybernetics and Intelligent Systems (CIS-RAM on international conferences and journals, such as using way its finds robot (A 2015 in Review ogy on “Rapid Feedforward Computation by Temporal Society to receive the Outstanding Outstanding Papertoreceive the TNNLS Society and Developmental Systems My plan is to continue to make “deliveringhigh- make to continue to is plan My Program Chair of 7th IEEE International Conference Nobel-prize winning discoveries of place cells and Encoding Encoding and Learning with Spiking Neurons” was progress inneuromorphic research. ranging from computational neuroscience, neuro morphic computing tomorphic computing robots. intelligent Neuromorphic Computing Research Center (NCRC) moving in the right direction. I am also looking also am I direction. right the in moving in the College of Computer Science. In the centre I the NCRC to being its own “solid brand” within“solidbrand” own its being to NCRC the top 10 universities in China, and I am heading the train young research to students research conduct brain-GPS algorithm for robots based on the 2014 IEEE Transactions onCognitive . IEEE Transactions Ourresearch , and , - -
QBI alumni QBI 2003–2004 KayleneDr Young people to around 30,andmore labswere relo- there, was I grew theInstitute from 10 about t e n t tute an et t o n n t e 1 ont therepeople to atthebeginning establish help to seethatthewholeproject wasasuccess. number of people working inside, and I was happy large the by excited was I building. finished the back in Australia a few years later that I got to see was I wasn’tuntil it architecturalbut drawings, new building had just been poured. I had seen the the of foundations the 2004, in London College and when I left to my start postdoc at University renovatedlaboratory campus, UQ the on space In 2003 we were carrying out our experiments in t a a prett e t n t eto e n ol e there so cating, progress, senseof wasthis and I JOINED QBI was one of the in early 2003, andwasone ofthe collaboration makes and better experiments the helpful to leads actually It science. in argue to discussions made me realise that itcan be good ence, but different areas of neuroscience. Those neurosci all obviouslybackgrounds,research of a small number of people from very different scientific discussions. The Institute was made up But I also remember some of the more animated QBI is the people. They became my second family. The thing Iremember the mostaboutmytime at sclerosis, dementia and mental health disorders. multiple of treatment the for therapies new ing develop in repair.braininterested also areWe improve to ways identifying on focuses ily primar group my whereTasmania, Hobart, in Research Medical for Institute Menzies the TeamResearch atGlial the of head now am I - - - .
broader research agenda. to allow me to get more involved in shaping the roles senior more on takenhave to hope I and goals. Ten years goes by pretty quickly in science, lab members pursue and achieve their own career invested in my team, and hope to see my current biological findings into the clinic. I am also very have successfully translated some of my basic research goals, and in the next 10 years I hope to personal own my on focused am I now Right the Australian research environment. inhelpingmesettlebackinto played abigpart career.my returnedI When from overseas they connections that I made at QBI have really helped From the early stages of my career, the scientific Queensland Brain Institute QBI alumni QBI Annual Report 2015 Annual Report M ENTOR SHIP
66 Mentorship Mentorship QBI ANNUAL REPORT 2015 Postgraduate students national andinternational recruitment pro Student Student Symposium. L–R: Laura Morcom, Gonzalo Almarza, James Fraser, Carol Ann Mason, Alessandra Donato. Above: The QBI Student Association invited Professor Carol Ann Mason as keynote speaker for the 2015 Postgraduate neuroscience bank: Lavinia Codd (Bartlett); 2015, adding invaluable knowledge to the world’s in PhDs 16 confer to honoured also was QBI two MPhils) and 13 international PhD students. dents—nine domestic students (seven PhDs and total enrolment figure also included 22 newstu Thecountries. 18 from students international students and two MPhil students, including 43 PhD 99 with candidates, enrolled 101 had QBI ra re ear or er e ree tu ent Swinderen); (Mowry); Chikako Ragan (Goodhill); Elizabeth Kita (Marshall); Thoen Denuelle Kerbler Yang (Jiang);Paola Spadaro. (Widagdo) Talwar (Lynch); IN 2015, QBI continued itshighly successful QBI 2015, IN (Coulson); (Coulson); (Srinivasan); Danay Baker-Andresen (Bredy); Daina Dickins (Kamke); Dickins Daina (Mattingley); Oscar Jacoby Gavin Taylor John Morris (Sah); (van alu re a Andrew and Martin andAymeric Xianfeng Xianfeng Hanne Hanne Georg Georg Sahil Sahil - - (van Swinderen). Ertekin Howarth Top Up:MdMoniruzzaman (Meunier); Allowance and they were also awarded the QBI ship in conjunction with a UQ Centennial Living International Postgraduate Research Scholar- candidates were successful in being awarded an UQI Partial Tuition Fee Scholarship. The following Technology) Living Allowance Scholarship and a and Science for Council National (Mexican CONACYT a awarded was (Marshall) Galan p.a. Mandiyam (Srinivasan), who each won a $14,150 included to work and study at QBI and the 2015 highlights Scholarships enable many of our RhD students across theworld. laboratories other to knowledge their taken have others while QBI at research their tinue Some of our student alumni have stayed to con Boeing Boeing Top. Upscholarship Debajyoti Karmaker (Vukovic); Moelter Jan (Goodhill); Mahadeeswara and Mahadeeswara Alejandra Lopez- Michael Michael Deniz Deniz - Other student successes in 2015 included: successesin2015 Other student Scholarship. ment) (Coulson) was awarded a JPA (Malaysian Govern Tuition Fee Scholarship, while arship Council (CSC) Living Allowance and the UQI Cao (Meunier), who was awarded the China Schol Other notable scholarships were received by • • • • • • • • •
Graduate SchoolInternational Travel Awards awarded(Cunnington), Ren nier) and atal e Luke Hearne Medical StudentResearch Conference 2015 SOM at Poster Best for Dean'sAward icine Casey Linton (Hilliard), won the School of Med Twin Research (ACETR) Travel Grant Scheme in Excellence of AustralianCentre the awarded Baptiste Couvy-Duchesne for Outstanding Research Higher Degree Thesis Anna Bode (Lynch), awarded the 2014 Dean’s Award RHD Committee QBI the by selected 2015, in paper published best the for Prize Publication $500 ma-Aldrich Gerhard abreakthrough about story research dementia in Gerhard Leinenga (Götz), who featured in a news Brain Bee Final Challenge Queensland PhD Project Presentation at the 2015 Australian Alessandra Donato (Hilliard), awarded the Best Member ofANS ot-Smith Award for the best poster by a Student Elli Grafton Sir the received (Sah) Yajie Sun graduate SymposiuminBiomedicalSciences presentation prizePost6th International the at poster a awarded Toni (Coulson), Turnbull was also the winner of the Sig the of winner the also was (Mattingley), no ara ana (Meu ant n a a alan (Wright), who was who (Wright), Yuanzhao Yuanzhao ------
programs, with five international winterschol researchUQ annual the of part as scholars summer and winter host to continued QBI three and students students international domestic places—five offered were eight strong made candidates and 100 applications the program inFebruary 2016. starting neuroscience was well underway in 2015, with Planning for QBI’s new Master of Philosophy in talk. best short Hunt entations and prizes were awarded to research. Students were judged on their pres Toni Turnbull talkson their presented short Aung Aung Kywe Moe, research findings, while presentedHunt lectures plenary ontheir u en , u en speaker. During this event, keynote as Biology Cell and Pathology of Department University’s Columbia from December, with Professor Carol Ann Mason QBI Postgraduate StudentSymposiumin second the including seminars, and events Institute, hosting and presenting a range of the to diversity scientific and vibrancy add to continued Association The QBIStudent interest inresearch/PhD study. research experience, and had expressed an 2015. Chinese Scholars for six weeks from 13 July, QBI hosted five Fudan and Wenzhou Visiting AIBN, and IMB UQDI, with participation In scholars foreighttoweeks. 12 summer nine and weeks, 10 to four for ars for best long talk and had moderatechosen scholars The atal e ro e atal e and Sarah , Soh Ming Rachel Templin and no no ara ana, Toni Turnbull for Siân BakerSiân , Almost Almost Sarah - - .
Postgraduate students and neuroimaging study schizophrenia: aclinical,neuropsychological, Characterizing copy numbervariants in Dr Andrew PhD Martin, Top-down andbottom-up processes in vision Dr OscarJacoby, PhD In vivo imagingofthe Dr ElizabethKita,PhD in Alzheimer’s disease Imaging basalforebrain dysfunction Dr Georg Kerbler, PhD altered in healthy older adults? cortices Is plasticityinthe human motor Dr DainaDickins,PhD for autonomous aerialnavigation Bio-inspired visualhomingstrategies Dr Aymeric Denuelle,PhD model of hippocampalstroke recovery inanEndothelin-1-induced The role of neurogenesis infunctional Dr Lavinia Codd,PhD of formercocaine self-administration methylation:anepigeneticwatermark DNA Dr Danay Baker-Andresen, PhD PRINC PRINC PRINC PRINC PRINC PRINC PRINC PRINC PROFE PROFE IPAL ADV IPAL ADVIS IPAL ADV IPAL ADVIS IPAL ADVIS IPAL ADVIS IPAL ADVIS IPAL ADVIS SSORH C ELIZABET MAN SSOR IS IS OR: PRO OR: PRO OR: PROFE OR: OR: OR: OR: PROFE OR: D YAM YAM
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LEY anaesthesia in Drosophila melanogaster anaesthesia inDrosophila melanogaster Presynaptic mechanismsofgeneral Dr Oressia Zalucki, PhD mapping and application inimaginggenetics Brain shapeanalysisby diffeomorphic metric Dr Xianfeng Yang, PhD of the most complex visual systems in the world Colour vision in mantis shrimps: understanding one Dr Hanne Thoen, PhD reality paradigmsin honeybees usingvirtual Unravelling control the sensory of behaviour Dr Gavin Taylor, PhD as therapeutic leads for pain treatment Dr Sahil Talwar, PhD inadaptive behaviour RNAs The role of regulatory longnon-coding Dr Paola Spadaro PhD expression in schizophrenia brain Analysis ofnon-coding RNA Dr ChikakoRagan,PhD reinforcement extinctioneffect The neural basisofthepartial Dr JohnMorris,PhD A PRINC PRINC PRINC PROFE PRINC PRINC PRINC PRINC PRINC SSOC IPAL ADV IPAL ADV IPAL ADV IPAL ADV IPAL ADV IPAL ADV IPAL ADV IPAL ADV OR MAN SSOR IATE PROFE Graduating students IS IS IS IS IS IS IS IS OR: OR: OR: PRO FE OR: PRO FE OR: OR: PROFE OR: OR: PROFE OR: PROFE D SSOR BRUNO V YAM YAM
D R S JOC RINIVAS Queensland Brain Institute SSOR TIANZI SSOR SSOR SSOR BRYAN MOWRY SSOR PANKAJ SAH ELYN WIDA
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Annual Report 2015 Annual Report S TINSHALL MAR EPH WIND GDO J LYN G IAN M
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68 Mentorship Mentorship QBI alumni QBI QBI ANNUAL REPORT 2015 2011–2013 Ann a ol in the scientific journal journal in thescientific laboratories, we were able to publish this story in Massimo’s lab, as well as from collaborating Through the and support work of many others broken. or cut is it when degenerates cell) how an axon (the longest structure of a nerve understand to tried I research my In worm. the in similar very are us in processes these underlying pathways and proteins genes, the ing, eating and sleeping. Additionally, many of from a fertilised egg to an adult, moving, breed the basic functions that we do, such as growing humans have, they are still able to perform all of we that cells the of billionth a than fewer far and amenability. While these tiny creatures have simplicity their by taken was I and beforelife never seen the small, elegant creatures in real had regenerate.I and degenerate nerves how facilities, research and people are world class. Theunknown. the intovoyage a on ship a of reminiscent physically is itself building The work. and study to place fantastic a was QBI worm, Massimo’s lab uses the 1mm-long, nematode re ear a tant unt lt e leo 201 Ienjoyedbecause Istayed itsomuch, asa with MassimoHilliard’s laboratory and then, QBI. I SPENT TWO-AND-A-HALF TWO-AND-A-HALF SPENT I I started as an Honours student in2011 asanHonours I started C. elegans , as a model organism to study Cell Reports at exciting years at . - end up back atQBI. end up wonderful country. Who knows, maybe I’ll even a is it Australiaas to back come to like would I future the in sometime overseas, studying and living of adventure the loving am I While in Massimo’s lab. the luck to be surrounded by during mytime had I people wonderful valuethe truly I again. back to QBI and see old friends and colleagues nervous to present, it was a pleasure to come group leaders do before. While I was somewhat I had onlyseen more senior PhD students and Wednesday Neuroscience Seminars, something I was kindly invited to give one of the regular QBI 2014, in Brisbane in holiday on was I When than before. behaviouralfocus more a with but worm, the of mind the into delve to continue can I Here, (IMP), of which the is Vienna a Biocenter.part the Research Institute of Molecular Pathology at Zimmer Manuel with PhD my commence to Austria, Vienna, to moved I mid-2013 In and adventure. instilled a drive to search for quality, opportunity ment as ascientist and person. develop my for essential were UQ, at degree undergraduatemy as well as QBI, at time My discovery are beautiful. the yearly art competition. Science, nature and of the beautiful within artworks the building and QBI also values creativity, as shown by the many between scientists, and departments the public. I enjoyed the connections that QBI encouraged Myyears there -
QBI alumni QBI QBI alumni QBI During an internship at CSIRO as part of my under A n an erra Srinivasan, moved just had there lab his from my future PhDsupervisor, Professor Mandyam me as a student was essential for me to growto me for essential was student a as me toprovided QBI that support of level the think I really enjoyable. and the social atmosphere in also general—were student BBQs onthe QBI balcony— Fortnightly lab. the visiting and seminars giving engineers and researchers, scientists, world-leading of stream constant a was there so and institute renowned internationally an is it because work and study to place exciting an was QBI traditionalusing guidancetechniques. unmanned aircraft much more efficiently than by a moving object could be performed by a small autonomously landing as such tasks tracking or ple bioinspired vision-based algorithms, difficult PhD,multi Formy combining by that showed I applied to the guidance of autonomous aircraft. ticularly interested in how those findings could be own motion through it. As an engineer, I was par interpret their surrounding environment and their how honeybees visionto use andotherinsects At QBI I worked with Professor Srinivasan to study tact and eventually made the move to Brisbane. being fascinated with his research so I got in con though it wasn’t my field at the time, I remember guidance systems for autonomous aircraft. Even those same principles could inspire the design of use vision to achieve feats of navigation and how Professor Srinivasan on honeybees and how they graduate studies, I attended a lecture presented by I FIRST DISCOVERED Dr Richard Moore Richard Dr that QBI whenI learned that 2008–2012 - - - - mously to and from the “hive” using a miniature autono navigate to RoboBee the for means a contributed I insects. of size the robots aerial control, by producing a swarm of flapping-wing the boundaries of manufacturing, efficiency, and Bee project was a cross-disciplinary effort to push with bees—but this time robotic ones. The Robo fellowship at Harvard where I continued my work After receiving my PhD I took up a postdoctoral your thesis. to think about applications of your work beyond mercialisation workshops that encouraged you also really benefited from courses like the com future collaborations and launching my career. I internationally,researchnetwork up my setting - - - of robotic bees. dayone to have bycleaned house my swarm a perhaps and ways, exciting and new in society autonomous systems, I hope to see them benefit ers. By helping to invent safer and more efficient self-driving cars and autonomous vacuum clean everydayof in form the life—mostin noticeably recently that robots have started becoming visible jobs we don’t want to do, but it is only relatively the of care take will that sizes and shapes all of robots promised been have we decades For and autonomy oftomorrow’s cars. safety the enhancing for systems vision smart developto world the around teams with work I vision system. In my current position with Valeo, Queensland Brain Institute QBI alumni QBI Annual Report 2015 Annual Report M ENTOR SHIP -
Mentorship Community QBI ANNUAL REPORT 2015 The 2015 Hand Heart Pocket Gala Evening, Evening, Gala Pocket Heart 2015 Hand The run by QBI and Alzheimer's Australia (Qld), (Qld), Australia Alzheimer's and QBI by run raised money for Alzheimer's disease disease Alzheimer's for money raised research and support services.
Community Through world-class research, QBI is To research accessible make neuroscience in the Australian and international communities international and Australian the in in community events. and understandable, in 2015 QBI researchers presented talks, guided tours and participated committed to improving the lives of individuals
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Queensland Brain Institute Annual Report 2015 Annual Report COMMUNITY
Community Community Au tral a uture e ono ro t Peter THE 2015 PETER GOODENOUGH QBI ANNUAL REPORT 2015 determine our futuredetermine our standard ofliving. Events continues to shrink and employment in the mining tocontinues employment and shrink mining the in Properly funding and commercialising Australian He said that the proper funding and commercial Mr Beattie said Australia should be looking to chal important most single the was it said He isation of Australia’s world-class research would decreasesindustry . that 50 per cent of future jobs would be in the in be would jobs future of cent per 50 that Germany,recognised and which China US, the research willdetermineourfuture standard ofliving knowledge sector. t e A n epte er 2 r eatt e are boom, as the traditional manufacturing industry lenge facing Australia'sfacing post-mining lenge economy Lecture wasdelivered by The HonPeter Beat isation of our world-class research world-class our isation of drivewill insights intoinsights howinnovation commercial and G oodenough Memorial Lecture Memorial - - - - The Peter Goodenough Memorial Lecture is Award forLeadershipExcellence in2008. Australia (AC) in 2012, and won the Biotechnology (1936–2004), (1936–2004), a QBI benefactor, whose personal Industry Organisation’sIndustry inaugural International Nanotechnology,Insti & and Bioengineering for cialisation Fund; ambassador for Life Sciences Life for ambassador Fund; cialisation Queensland; a joint Adjunct Professor at The at Professor Adjunct joint a Queensland; of The University of Queensland's Industry Queensland's of University The of University of Queensland’sInstituteof Australian University named in honour of Mr Peter Goodenough Peter Mr of honour in named He was awarded a Companion of the Order of Order the of Companion a awarded was He Council. Engagement He is Director of the Medical Research Commer Queensland of Premier was AC Beattie Peter to fundfundamentalscientific research. member a and Bioscience; Molecular for tute time wasalsotheMinisterfor Trade. battle battle with motor neuron disease led to a bequest between 1998 and 2007, and for most of that of most for and 2007, and 1998 between - -
orporate an o un t roup n2015 donors, our engagementwith meaningful QBI QBI Breakfast (pictured above) Daniel Gschwind Professor Justin Marshall CoralWatch and Ms SusanPearse Professor Jason Mattingley Professor Pankaj Sah The Power ofAttention Nancy Frates Dr ShyuanNgo Professor Naomi Wray MND: IceBucket Challenge Libby Dunstan Dr Lavinia Codd treatment andsupport Stroke: thelatestinresearch, Professor Elliott Sherr Professor Linda Richards Research inAutism SpectrumDisorder Breakfasts in 2015: F S WIT S SINCE BEING INTRODUCED C INAN UPPORTED UPPORTED H S Breakfast Series has continued to enable TROKE S QUEEN G IAL PLANNIN BY MIND G BY A
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in 2013,the tralia port services ofAlzheimer’s services port Australia (Qld). disease research at QBI, and the care and sup All funds raised went directly into Alzheimer’s and QBI. of the work conducted by Alzheimer’s Australia er’s Australia her role as National Ambassador for Alzheim in performers Buttrosethe Ita joined AOOBE director NormaMarschke. and the Aditaya String Quartet, led by musical profundo David Hibbard, baritone Shaun Brown soprano Mia Yaniw, tenor Jaewoo Kim, basso night included soprano Natalie Peluso, mezzo the on featured artists class world The ica. halls inEuropethroughout and Amer concert performing careers spectacular had have The line-up was filled with opera singers who and classicalmusic. operaof night werebya who dazzled guests gala evening was attended by more than 200 of Freemasons Queensland, and Morgans, the supported by Hand Heart Pocket, The Charity River.GenerouslyBrisbane the overlooking party cocktail a and House, Customs iconic Brisbane’sof Room Long the in formances per unforgettable saw 31 July on Evening Pocket Gala Heart Hand annual second The re ear an are awareness and funds Alzheimer’s for disease G H QBI PARTNERED WITH ala Evening and (Qld) to H eart Pocket eart . She spoke about the importance She spoke about the importance create a lavish event to raise Alzheimer’s Aus
- - - - - Queensland Brain Institute Annual Report 2015
Performers at the Hand Heart Pocket Gala Evening (L–R): Jaewoo Kim, Natalie Peluso, and Shaun Brown.
COMMUNITY Community Australian Brain Bee Challenge Bee Brain Australian QBI ANNUAL REPORT 2015 The Australian Brain Bee Challenge (ABBC) Bee Challenge Brain The Australian is QBI’s public outreach program for high school students. for high students. school program public outreach The ABBC hasthree rounds: THE ABBC PROVIDES en e re ear engage families, teachers andthe wider community, in learning about neuroscience about learning in neurosci and • • •
Territory representative competes to become students are invited to attend a full day at a at day full a attend to invited are students and disorders neuroscience research instituteandbecome round two, a State/Territory ABBC final where round one, an online quiz, held in March during round three, a national final where each State/ Brain Awareness Week, which tests students’ ture, function, anatomy,function, ture, disease neurological their State/Territory champion the Australian Champion. knowledge and understanding of brain struc brain of understanding and knowledge young Australians, as as well their to to an opportunity - - The programThe todayexciteaimed the young for The QueenslandABBC iscoordinated by QBI’s Zhao (Bartlett laboratory) and Ilvana Dzafic Ilvana and laboratory) (Bartlett Zhao Associate Associate Professor Bruno Van Swinderen. Each 21 and was attended by 200 Year 10 students Year10 200 by attended was and 21 (Mowry laboratory).(Mowry ance activity, heart rate, movement, and body and movement,rate, activity, ance heart and Associate Professor Paul Shaw (Washington Ingham, Townsville, Rockhampton andWoree. from 47 schools, as well as their teachers and teachers their as well as schools, 47 from QBI’s research laboratories to andtheopportunity year, round one attracts more than 1000 Year 10 fantastic presentations from Associate Professor Queensland students. Round two, the Queens- the two, Round students. Queensland on the day University), as well as QBI PhD Student Project Student PhD QBI as well as University), regional areas to attend, including Biloela, Cairns, Empatica wristbands to monitor skin conduct skin monitor to wristbands Empatica people about neuroscience and included tours of parents. Many of the students travelled fromtravelled students the of Many parents. use use QBI’s Science of Learning Research Centre Megan Campbell (Cunnington laboratory), Jing presentations by Alessandra Donato (Hilliard David Caldicott (Australian National University) temperature response to the different activities land ABBC state final, took place at QBI on July laboratory), Natalie Groves (Burne laboratory), (Burne Groves Natalie laboratory), . Students and teachers also heard - ABBC on July 19, 2016. ABBC on July19, ABBC Champion. Associate Professor van Swin Australia’s State and Territory ABBC finalists gath After a close individual competition which fin which competition individual close a After ABBC Queensland Champion Abigail Green Above AbigailGreen Champion Queensland left:ABBC deren praised all of the students who participated always loved science, which was why I did the did I why was which science, loved always well, placingthird. challenge, and I found being involved in the ABBC laboratory.Hilliard the “I’vein experience work champions we have produced,” he said. After the QBI looks forward to hosting round two of the of two round hosting to forward looks QBI Queensland ABBC Champion and did extremely and Associate Professor Brunovan Swinderen. on the day, becoming the 2015 Queensland 2015 the day,becoming the on ered at Sydney University and Western SydneyWestern and University Sydney at ered University on December 7 and 8 for the ABBC the for 8 and 7 December on University neuroscience knowledge. “Abigail can be really “Abigailbe knowledge. can neuroscience really interesting,” shesaid. round two final, Abigail spent a week at QBI doing proud of her achievement in representing Queens House student Abigail Green was the winner the was Green Abigail student House National Final. Abigail attended as the 2015 the as attended Abigail Final. National in the 2015 ABBC for their competitive spirit and ished with a sudden-death final, Somerville final, sudden-death a with ished land and joins the long line of tremendous state - - - -
Queensland Brain Institute Annual Report 2015
ABBC Queensland team winners from Kirwan State High School.
COMMUNITY Community QBI ANNUAL REPORT 2015 Philanthropy est: www.qbi.uq.edu.au [email protected] Website: Email: 6301 +6173346 Facsimile: 6413 +6173346 Telephone: Brisbane QLD4072 The University ofQueensland Building 79, StLuciaBuilding 79, Campus Queensland Brain Institute To at: please contactus theInstitute, howyou discuss cansupport can help support QBI’scan helpsupport research effort: There are manyways inwhichyou D QBI: How to support Under current giftsto legislation, QBIare taxdeductible. All members of QBI sincerely thank our valued donors for their support in2015. All membersofQBI sincerely thank ourvalued fortheir donors support andgenerosityis grateful ofitsbenefactors. forthesupport QBI relies on both public and private donations to continue its research programs and and neurotrauma. ments for conditions such as dementia, stroke, motor neuron disease, multiple sclerosis function, QBI researchers are working to develop new, more effective therapeutic treat brainregulate that mechanisms fundamental the of understanding the improving By 5 per ento t e ur en o ea e nAu tral a ative diseases andmental health disorders, whichcurrently account for astaggering RESEARCHERS AT QBI Fundraise thecommunity using • • laboratory Undertake dedications • • • • • • onations fundraising platformEveryday Hero Provide giftsinmemoriam ProfessorialSponsor Chairs career researchers Provide fellowships forearly/mid- Fund scholarships for talented students Purchase equipment scientific research area Make adonationforspecific are dedicated to unlockingthe mysteries of neurodegener
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- - - Principal Morgans Limited Financial FamilyMolomby Testamentary Trust Maclean Distributors Ltd Pty HopgoodGanim Lawyers Hillstone StLucia F. RocheLtd Hoffmann-La Equity Trustees Limited Attorney-General(Prisoner Trust) and ofJustice Department Corporation Limited Brisbane Airport Ltd Barpete Investments Pty ausDoCC Financial Planning A Clear Direction D NetApp Australia Mater Foundation Index Groupof Companies Pocket Hand Heart Frank Youngleson David MersonFoundation Crommelin Family Foundation Major The Stafford Fox Medical Research Foundation Estate ofMaureen Gilmartin onor Organisations G ifts G ifts
TravelSIM Australia Ltd Pty The Yulgilbar Foundation Wilgarning TrustThe The ClemJonesFoundation Children'sThe Trust Stage Five P/LATF StageFive Trust Inc South Soroptimist Brisbane International Ltd Siemon Investments Pty ShowChoir Queensland Service Ambulance Queensland AustraliaPwC Ozprop Ltd Holdings Pty Nicol Foundation FundEndowment Ltd Pty The University ofQueensland Foundation Limited The MNDandMe The Helpful Foundation Temron Ltd Pty Robyn Hilton Pogliane Ltd Investments Pty
Philanthropic donors Julieann ConwayJulieann Clement Jenny Valma Clarkson Baiq Citra Brad Church Vanessa Christensen Kay Christensen Siu Chow Jeiran Choupan Guobo Chen Joanne Case Alexandra Carter Elene Carides Carides Constantine Tracy Campbell Peter Cairns Zoe Cahill Timothy Butler BurkeMary Helen Brosnan Robin Bright Elizabeth Brennan Mark Breen BrandCheryl Brand Robert Renae Bourke Stephane Bouchu Kylie Border Christine Bopp Jennifer Bloomfield Amy Bibby Beben Benyamin Alan Bennett Pauline Beames Geoffrey Bayliss AM Jane Bartlett Bartlett Perry Gregory Bartlett Andrew Bakshi Kristine Baillie Anne Bachelard Kristine Ash Beverley Angus Ming Anderson John Alexander MP J Alexander AhrensHarry Individual D onors Michelle Glancy Diane Givler Dorothy Gilliam Sascha Gibson Sophie Gibbs Colleen Gibbons Trevor Garby Euphemia Gannon Warren Gamack Anita Freeman James Fraser FrancisKathryn Harold Foxton Kim Forsythe Debbie Fogg Jess Fogg Paul Figallo Robyn Farrell Dale Fandrich Harrison Evans Shelley Ellen Van ChungDuong Ruth Duncan Chloe Dubini Samuel Drew Michele Dougherty Aurelie Dolch Kellie Doherty Karl Dodd Ross Dickson John DiMauro Denver Mary Jade Dempsey David DeJong John Dashwood Ngoc Dang Emma D'Ahremberg- Margaret Curnow Candice Cummings Bob Craig Dominic Cradick Christine Cowell Ivan Cotchin Mikaeli Costello Fabio Cortesi Lindsay Cornell Manno Jennifer Kennedy John Kelly Rachael Kelly Julia Keith Anima kapadia Neville Kajewski Gayle Jones Kim Jones Effie Jones Robyn Johnston Phillippa Johnson Dinah Johnson Allison Johansen Roxanne Jemison Sandi Jeffrey Penny Jeaffreson Peter James Melissa Jackson Desmond Jack Firman Idris Alexandra Hutchinson Noyce Hurst Chin-Chuan Huang Faith Howell Tracey Hopkins Michelle Homes Adrian Holt Lindsay Hollingworth HeynenAnthony AMJohn Heussler Lynelle Hertslet Nick Hermes Richard Hermes Gregory Henricks Janice Hegarty Barbara Hayes Stefanie Hardacre Oriel Handley Donald Grimley Kate Grenville Libby Gregoric Fran Gray Jacob Gratten Noella Grant Greg Gough Marie Gouanvic Juergen Goetz Daphne Maclean Hilda Maclean Helena Macey Pam MacDonnell LyonsMary Richard Lynch Therese Lucas Max Lu Fran Loughrey Ian Loughnan Keith Locke Liu Lianxiang Anne Little Linthorne Robert James Linfoot Lindenmayer Stuart Maija Liiv li Chuanzhou Nerida Lewis Gabriel Levy- Linda Levett Christa Levania Maxwell Lennox Gerhard Leinenga Winnifred Lee Ming Lee Joan Lawrence AM John Lavery Shirley Larsen Bruce Large Sandy Lannantuono Nikki Langton Louise Lang Peter Landy Mbaye Lamine Sandra Lacey Nyoman Kurniawan William Koppe Helen Komoff Yvonne Kirkegard Lorraine Kinnest Tanna Kincade Glen Kilpatrick Shaistah Khan Elham Keyvani Sarah Kent Bencheton
Elizabeth Nason Rebecca Nankervis Nanda Murti Munson Curtis Adam Mullins Stella Muller Vivien Mullan Bevan Muldoon Jake Moss Lyn Moorfoot Georgia Moore Siobhan Molloy Dawn Mirapuri Kate Mills Natalie Mills Michael Mills Shelby Mills Tanya Merrill Allan Merlehan Deepak Mehta Divya Mehta Brendan Meagher Debbie McQuaid Christopher Mcnee Cath McMurchy Nicole McMillan Michael McMahon Marnie McLaren Moya McKenzie Marcia McInnes James McGaw Terry McGarrigle Rebecca McCue Joscelyn McBain Barrie Mawby Jason Mattingley Cody Matthews Donald Mason Stacey Martin Kymberly Martin Janice Marshall Gavin Marsh Joyce Markwell Riza Margaresa Maier Robert Bill Maddock Erin Madden Isabelle Rickards Shirley Riches Ruth Richardson Kristy Reynoldson Anne Reynolds Nicola Reeves Rachael Puddephatt Glenda Powell AM Paul Potter Jelena Popov Kerry Pinkstone Janette Philp Nicky Phillips Phillips Suzie Tom Petty Bruce Petty Judith Perrott Angelo Pennisi Elizabeth Pearl Jaikisan Patel ParkerSuzanne Manuel Paraskevos Marlene Paradine Tishila Palliyaguru Wayne Osburn Michael Oakes Denise O'Malley Julianne O'Leary Janet O'Dwyer Patricia O'Connor Simon O'Brien John Nolan Christopher Nolan Helen Noad Rose Nisbet Rebecca Nisbet Loc Tuong Nguyen Duyen Nguyen Catherine Nguyen Shyuan Ngo Newman Anthony Audrey Neill Josh Neil Marjorie Neil Desley Neil Judith Nedderman Denis Nave Rosemary TennentRosemary Trish Taylor Lina Tata Siham Taruc Elisabeth Tarigan Sarah Sullivan Shuichi Suetani Peter Stratton Kevin Stewart StevensonBarry Maureen Stevenson Margaret Steinberg AM James Steeves Janice Steel Mark Staunton Staunton Mary Liam Staunton Barbara Stace Joseph Spelta Sortaria Putri Michael Snelling Danina Smith Angela Skinner Nicola Simpson Catherine Simons John Siemon Lindsay Sheedy Lewis Shaw Taish Shaw Akshat Sharma Sophie Sharkie Peter Shannon Dayton Senchuk Graham Schrodter Andreas Schnieders Geoffrey Sattler Bambang Samodra Danyal Saleh Liam Ryan Bayront Rumondor Paule Ruggeri Jess Ross Oleksiy Romashko Lisa Rolle Brian Robinson Katherine Robbins Olga Ristic Philanthropic donors Queensland Brain Institute Adriana Zukiwskyj Pingping Zhao Zong Zhang Nicole Zanyat Elizabeth Yates Leigh Yates Maria-Magdalena Sarah Wyche Catherine Wroten Peter Woodward Alan Woodruff Lucile Wolf Lisa Wittenhagen Matthew Wissemann Daniel Winkle Coral Wilson Franca Wilson Margaret Williams Dorothea Wilkinson Margaret Wilkins Jason Wilkins Adishta Wijayanto Harold Westaway Jean West Stephen West Michael West Wendy West Melina West Genevieve Wells Helen Weir Catherine Webster Ralph Watson WareMary Matthew Ward Alimin Adi Waloyo Richard Wallace- Janice Walker Naomi Visscher Alison Van Niekerk Maciej Trzaskowski Beverley Trivett TooheyAnthony John Thong David Thompson Georgia Thomas Isabelle Tessier Xantopol Barnett Annual Report 2015 Annual Report COMMUNITY
Community QBI ANNUAL REPORT 2015 QBI researchers in 2015. in researchers QBI Journal covers by by covers Journal
Publications The quality and number of scientific publications world-class calibre of our researchers. top echelons of neuroscience research. In 2015, QBI authors published 273 peer-reviewed QBI representation on prestigious editorial editorial prestigious on representation QBI produced in 2015 stands QBI researchers in the papers, 21 of which were in Nature boards, including the QBI-initiated journal npj Science ofnpj Learning Science , attests to the journals.
Queensland Brain Institute Annual Report 2015 Annual Report P C UBLI ATIONS
Publications Publications QBI ANNUAL REPORT 2015 npj Science of Learning Science npj launched an open-access Nature Partner Journal dedicated dedicated Journal Partner Nature open-access an launched In 2015,In Publishing with Nature collaboration in Group, QBI to science the of learning— THE PARTNERSHIP WAS Group, QBI will work with a respected and presrespectedand a with work will Group,QBI an n ol e e eral ta and builds onthe success ofthe Science of currentand Director Professor Pankaj Sah, Mattingley will serve as Associate Editors for the Professor Stephen Williams and Professor Jason QBI’saddition, In journal. the of Editor-in-Chief be will SLRC, the directs who Sah, Professor journal. By partnering with Nature Publishing Nature with partnering By journal. tigious brandtigious inacademicpublishing. Learning Research Centre (SLRC), whichis founding headquartered at headquartered The University Queensland of npj Science of Learning Science npj Director Professor Bartlett Perry initiated by QBI . - The official launch of the journal took place at place took journal the of launch official The An outstanding international editorial international board outstanding An has Group, QBI is positioning itself at the forefront the at itself positioning is QBI Group, speakers and panel members from across Aus Customs House in April 2015, with a Science of approach here iskey: understanding the science at conferences in Australia and beyond, promot Council. The symposium was attended by more Chief of Chief In creating this journal with Nature Publishing Nature with journal this creating In event. The symposium featured more than 20 than morefeatured symposium event.The of learning needs to be complemented bypracto complemented needs be learning of of educational neuroscience. This is a relatively ers from neuroscience, psychology and education new research field that aims to integrate the find nal’s success. In collaboration with Learning symposium held to coincide with the with coincide to held symposium Learning Economic Sciences of the Australianthe of EconomicResearchSciences andBehavioural Social, for DirectorExecutive Dr Soo-Siang Lim; Dr Philip Campbell, Editor-in- Campbell, Philip Dr Lim; Soo-Siang Dr Director of the US Science of Learning Centers Centers Learning of Science US the of Director ings ings of neuroscience, psychology and education ing thejournal’s missionandscope. makers. the expertise of educationalists and engaging and educationalists of expertise the tical implementation in classrooms, drawing on to improve how we learn. The interdisciplinary The learn. we how improveto than 100 researchers, educators and policy and educators researchers, 100 than tralia and internationally, including the Program both teachersandpolicymakers. board members have engaged leading research been assembled and will help to ensure the jour- Nature ; and Professor Marian Simms, Marian Professor and ; Nature staff, - - - - -
To reach this broad cross-section of the commu AboveEditor-in-Chief, left (L–R): dence-based improvements to education. venture for QBI, but ultimately it is the generalthe is it ultimately but QBI, for venture sible—either physically or intellectually—to these these physically orintellectually—to sible—either In short, In short, yet until now the research findings that drive that findings research the now until yet for non-expert for readers.non-expert Debate and information content within the journal will be accompanied by on learning and education are of huge interest to easy-to-understand summaries that are written Campbell, Professor Perry Bartlett, Professor Pankaj Professor Bartlett, Perry Professor Campbell, nary nary and accessible journal that allows anybody nity, two steps have been taken. First, the journal public who has the most to gain through evi through gain to most the has who public parents, teachers, politicians and policy makers, parties. parties. implications for education. This is an exciting an is This education. for implications is online and open-access, freely accessible to accessible freely open-access, and online is improvement and reform have not been acces been not have reform and improvement the science of learning, and to appreciate the appreciate to and learning, of science the to follow the latest research and discussion into the public. Second, the highly technical research Sah andProfessor Peter Høj. npj ScienceofLearning npj Science of Learning is an interdiscipli Nature Philip: Dr changesthat. - - - - QBI publicationsQBI Agerbo E, Sullivan PF,Sullivan E, Peder Agerbo BJ, Vilhjalmsson Adams MJ, Adams are alsoincluded. Report Annual Publications which were omitted from the 2014 eitheronlineorinprint. the firsttimein2015, following publications, which were published for students (indicatedinbold)contributedto the researchersQBI and research higherdegree Baker S Arnedo J, Svrakic DM, del Val C, Romero-Zaliz C, Val del DM, Svrakic J, Arnedo Arden R, Luciano M, Deary IJ, Reynolds CA, Peder de AC, Conibear NL, Daly RJ, Clark M, Akcan al. Hollegaard MV, Meier S, Mattheisen M, Mattheisen MV,S, Hollegaard Meier O,Mors CB, AD,Borglumsen DM, Hougaard study and meta-analysis and study for schizophrenia: a Danish population-based risk the and disorders, psychiatric of history score, parental socioeconomic status, family Alzheimer’s Research and Therapy Sciences Proceedings of the Royal Society B: Biological helper care in a cooperatively breeding bird.cooperatively breeding a in care helper and parental on effectsenvironment social and genetic Social (2015) BJ Hatchwell animal models about cerebral multi-morbidity wide association studies. association wide genome- independent three in Confirmation hidden risk architecture of the schizophrenias: of Psychiatry de Erausquin GA, BJ Mowry [includes Consortium Schizophrenia of ics Genet- Molecular H, Hernández-Cuervo R, doi: 10.1093/ije/dyv112 [Epub ahead of print]. genetic. mostly is lifespan and intelligence between & K sen NL, Plassman BL, McGue M, Christensen . 104: 682-692 conotoxins. P-superfamily of toxins into cyclotides: backbonecyclization Mari F & Craik DJ (2015) Transforming cono MD,Heghinian A, Faoite 72: 635-641. [includes Wray NR ] (2015) Polygenic risk Visscher PM & Götz J & International Journal ofEpidemiology 282: 20150689. 20150689. 282: , Mannarelli ME & ME Mannarelli Robinson MR, ], Fanous AH, Pato MT,Pato AH, FanousCN, Pato ], 172: 139-153. 139-153. 172: (2015) What we can learn from et al. (2015) Theassociation (2015) Uncovering the , Adams DJ, Adams Sahil T, . . American Journal JAMA Psychiatry Biopolymers 7:11. et et - - - .
Bednark JG, Bednark Bicknell BA, Dayan P & Baker-Andresen D, Bender D,Bender Benson MJ, Thomas NK, Berenos C, Ellis PA, Pilkington JG, H, Benham Bareham CA Bednark JG, Bednark movements. complex of rhythm and ordering sequential (2015) Basal ganglia and networks cortical for ence acentrus wardi sions. sions. limits of chemosensation vary across dimen- 1810-1830. and protracted abstinenceinmice. ylation following cocaine self-administration meth DNA neuronal in variationsPersistent & AJ Lawrence R, worth Research Clinical Rheumatology Research, andPractice Psychology of Consciousness: Theory, “business-as-usual” CO “business-as-usual” and “reduced” of Effects (2015) S Dove & epilepsy models epilepsy tion of complement receptor C5ar1 in murine A novel anticonvulsant mechanism via inhibi Lynch JW free-living population. a in traitssize body of architecture genetic of Heterogeneity (2015) JM Pemberton & 76: 87-97. infection-associated arthritis. in genetics of Role (2015) R Thomas & LM 10: e0131442. on on the algal territories of the damselfish genetics to spatialbias? (2015) Does left-handedness confer resistance dictions and implicit measures of agency.of measures implicit and dictions & Cunnington R (2015) preIdentity-specific . 9:421. Nature Communications , Kline D, Diaz-Pulido G D,Diaz-Pulido Kline , CM Champ 4:1-11. , Baillet AC, Rehaume AC, Baillet Robinson PC, , , Bekinschtein TA, Scott SK & Manly T Poonian SK, , Woodruff TM & Borges K (2015) K Borges & WoodruffTM , & MEJ Campbell Frontiers in Human Neurosci- (Pomacentridae). Scientific Reports Zhao Q, . . Neurobiology ofDisease (2015) The GJ Goodhill Palghat K, Molecular Ecology Talwar S, Hodson MP, 2: 253-268. 2:253-268. 2 emission scenarios emission Li X, Jupp B, Ches Bredy T(2015) Lee SH, Best Practice & Cunnington R 6: 7468. 6:7468. 29:213-225. McFadyen J . 5:9162. PLoS ONE Neuroepi- Gratten J Pom 24: 24: - - - - -
Bjørge MD, Hildrestrand GA, Scheffler K, Sugan , Giovanni Galizia C, Galizia GiovanniBiergans SD, Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Bodea GO Bodea & Blaess S (2015) Establishing diver Bigdeli TB, Ripke S, Bacanu SA, Boyd RN, Baque E, Piovesana A, Ross S, Ziviani Bosch DS, Brennan F & F Brennan cord repair spinal complement to inflammation acute Neuroscience Claudianos C Claudianos Fadok JP, Lu T, Poe MM, 2671-2678. 2671-2678. Reports chiatric Genetics B:Neuropsy - Journal ofMedicalGenetics Part Dscam2 Corvin A, Corvin Gejman PV, Rietschel M, Cichon S, St Clair D, olfactory training in honey bees. honey in training olfactory appetitive after genes memory-associated (ABI). and adolescents with an Acquired Brain Injury children for program training multi-modal web-based a of trial controlled domised iety-like behavior in mice. in behavior iety-like and Mutyh DNA glycosylases modulate anx Bredy] TW (2015) Synergistic actions of Ogg1 ila melanogaster 10: 1596-1598. Whittingham K, J, Sakzewski L, Barber L, Lloyd O, McKinlay L, 18: 1493-1500. extrasynaptic inhibition. [includes . 589: 3773-3785 cases with a family history of illness. greater polygenic loading for schizophrenia in reveals study association Genome-wide Visscher PM, VågbøVetlesenCB, L, Eide S, V,Rolseth AD,R, Rowe than A, Kuśnierczyk (2015) Mitii sity in thedopaminergicsity in . system BMC Neurology Van Swinderen B & Millard SS (2015) 5: 16223. 5:16223. affects visual perception in Sah P] (2015) Regulating anxiety with et al. et (2015) TargetingRuitenberg M . . TM Neural Regeneration Research RegenerationNeural 9:149. (2015) ABI: study protocol of a ran a of protocol study ABI: Wray& NR [includes Gratten J et al. . 171:276-289[Epub2015]. . . Frontiers inBehavioral [includes Cunnington [includes R] 15:140. Dnmts Nature Neuroscience Xu L Xu Mowry BJ Mowry Lee SH Cell Reports Cell , Cook JM, and et al. Reinhard J FEBS Letters FEBS Tet , , Scientific [includes American American , Drosoph- Wray NR, Lee SH ] (2016) target et al. 13: & - - - - ,
Calvey T, Alagaili AN, Bertelsen MF, Bhagwandin A, , Bunt J, Burrell JR, Halliday G, Kril JJ, Ittner L, Ittner JJ, Kril G, Halliday JR, Burrell Burianova H, Marstaller L, Marstaller H, Burianova Brennan FH, Gordon R, Lao HW, Biggins PJ, Taylor Bui M, Bui Bulik-Sullivan BK, Loh PR, Finucane HK, Ripke S, the Euarchontoglires: a Lagomorph, Euarchontoglires:a the identifiable neural systems in two species of organisation of some immunohistochemically Nuclear (2015) PR Manger & Pettigrew JD March 2015]. capensis . continuum. totemporal dementia-motor neuron disease fron The (2015) JR Hodges & MC Kiernan roscience functional connectivity in the aging brain. relation of structural integrity and task-related The (2015) D Reutens & M Ziaei F, band Genetics Journal of Chemical Neuroanatomy ofChemical Journal Scientific Reports robiology ofAging SM, Franklin RJ, Woodruff TM & following spinal cord injury.cord spinal following astrogliosis and inflammation acute trols (2015) receptor The complement C5aR con age 14. onic versus dichorionic twin pairs in blood at in genome-wide association studies. distinguishes confounding from polygenicity regressionScore LD (2015) BM Neale & AL & expression during neocortical development. neocortical during expression Gratten J, [includes Psychiatric Genomics Consortium Yang J, Schizophrenia Working Group of the 18: 680-685. (2015) PAX6 does not regulate similarity similarity Sharing a placenta is associated with a greater & GW Montgomery NG, ], Patterson N, Daly MJ, Price MJ, Daly N, Patterson BJ], Mowry Benyamin B , Lim JW, Twin Research and Human Genetics , and a Scandentia, 47: 291-295. 47:291-295. in DNA methylation in monochori in methylation DNA in 35: 6517-6531. 35:6517-6531. Lee SH Lancet QBI publicationsQBI , L, Zhao , Shah S, Shah 5: 10668. 5:10668. Queensland Brain Institute 36: 2830-2837. 36:2830-2837. , [Inpress: accepted31 Wray NR, & Richards LJ S& Mason Choupan J , Martin AK, Henders Martin McRae AF(2015)McRae Annual Report 2015 Annual Report Tupaia belangeri Journal ofNeu P Ruitenberg MJ Visscher PM Visscher Nfia C UBLI , and 70:1-19. Sepehr Götz J, Götz Nature Lepus ATIONS Neu Nfib ------.
Publications Publications QBI publicationsQBI QBI ANNUAL REPORT 2015 Capurro A, Chew YL, YL, Chew Calvey T, Patzke N, Kaswera-Kyamakya C, Gilis- & Vickerstaff R (2015) Sensory and Sensory (2015) R Vickerstaff & Cheung A Carter A & A Carter Child S, Goodwin VA, Perry MG, VA, Perry Goodwin S, Child Carmona-Mora P, Cao Y, Chen Chen F, Lv X, Fang J, Yu S, Sui J, Fan L, Li T, Hong & Perreau VM (2015) Computational deconvo disorder: Aresting-state FMRIstudy depressivemajor on induction meditation relaxation body-mind of effect The (2015) of Affective Disorders er-race contact. response to others’ pain is reduced with oth Cunnington R(2015) Racial bias inneural ponse to oxidative stress. res- in accumulation nuclear SKN-1 intestinal regulates (PTL-1) repeats tau-like with protein Handbook ofNeuroethics Journal of Theoretical Biology Journal ofChemical Neuroanatomy nuclei inthree strepsirrhine primates: echolaminergic, serotonergic and orexinergic cat cholinergic, of Organization (2015) PR sen E, MF,Bertelsen regulation. of GTF2IRD1 demonstrate a role in chromatin localization patternand interaction partners demidoff update errors which can affect path integration. Research qualitative evaluation.qualitative ated review system in rheumatoid arthritis: a Byng R(2015)Implementing apatient-initi Whan R, Hardeman E, Y,M, Cha Dottori C, W,A, ales Lee Alshawaf analysis. tissues using population-specific expression Parkinson’s andHuntington’s disease brain lution of genome wide expression data from Y,W,Wang X, Wang drecht: Springer. neuroethics? In J Clausen & N Levy (Eds.), Levy N & Clausen J In neuroethics? Contreras-Huerta LS Götz J Bodea L-G, Schaefer P, Luthi-Carter R Hall WD , , Frontiers inNeuroscience 15:157. Perodicticus potto Human Genetics Human & Nicholas HR (2015) Neuronal Neuronal (2015) HR Nicholas & Widagdo J Cortex . (2015). Pettigrew JD & Manger et al. et et al. 183: 75-82. 183: BMC Health Services BMC Health Services 70:68-78. Aging Cell (pp What is addictionis What , Tomasetig F, Can [includes JiangT] [includes (2015) The nuclear and and , . 134:1099-1115. & McFadyen J . . 995-998) . 372:217-221. & Gericke CA Lemur catta 14: 148-151. . 70:42-57. 8:441. . Journal Journal Galago Galago Dor ------. Chu C, Fan L, Eickhoff CR, Liu Y, Yang Y, Eickhoff Colvin RJ & Andersen OM (2015) The A-B-C The (2015) OM Andersen & Coulson EJ Cortesi F Cortesi Cristofori-Armstrong B, Costello M-E, Cocchi L Cooray GK, , Cui X, human disease and how it relates to arthri to relates it how and disease human (2015) MA The intestinal microbiome in Neurophysiology alis on neuroimagingon coordinates basedarchitecture co-activation functional Estimation (CoPE): An approach for modeling SB & Journal of Neurophysiology of Journal networks using a hybrid process algebra. for SORting APP. neuronal ionchannels. of studies pharmacological and biophysical oretical Science Computer Research Clinical Rheumatology ness benefits to a mimic. a to benefits ness fit multiple confers plasticity Phenotypic W,burger Salz HN, Skold EC, McClure Phillips GA, . 304: 90-100 & Rash LD (2015) LD LynchRash & JW GF,King JL, Stow Z, Dekan JD, Griffin DL, 135: 1-3. 25: 949-954. stimulation onlarge-scale brain dynamics. theta-burst excitatory and inhibitory local of M & . 117: 397-407 tis and spondyloarthritis and tis ity networks in normal adolescence. normal in networks ity L (2016) The maturation of mismatch negativ [Accepted manuscript]. tcs.2015.08.019 N-cadherin N-cadherin a possible mediator. d regulates tyrosine hydroxylase expression: 14763. , R, Pertile as an alternative source of oocytes for oocytes of source alternative an as Mattingley JB (2015) Dissociable effects Jiang T (2015) Co-activation Probability , , , Sale MV, Lord A, Zalesky A, Breakspear (2015) Modeling and analysing neural , Feeney WE, Ferrari MC, Waldie PA,Waldie MC, Ferrari WE, Feeney , , MI, Garrido Brismar T & Hyllienmark & Cheney KL (2015) KL Cheney & Marshall NJ , PC, Robinson Benham H & Brown (2015) Vitamin Eyles Vitamin DW(2015) Liu P& Journal ofNeurochemistry 127: 520-529 [Epub 2015] [Epub2015] 127: 520-529 , Soh MS, Scientific Reports Scientific . . . . 113:3375-3385 Best Practice & Current Biology doi: 10.1016/j. doi: Talwar S, Brown Xenopus bore - . . Neuroscience NeuroImage 29:202-212. Clinical The- 5: 5: - - - -
, Steneck RS, Tager D & Pandolfi JM Pandolfi & TagerRS, D Steneck Dean AJ, Davies G, Armstrong N, Bis JC, Bressler J, Bressler JC, Bis N, Armstrong G, Davies & Denuelle A & N Cummins & Denuelle A Cui Y, Liu B, Zhou Y, Fan L, Li J, Zhang Y,Zhang WuJ, Li Y,L, Zhou FanY, B, Cui Liu de Busserollesde F, NS, Hart Hunt DM, Davies WI, de Vries PS, Chasman DI, Sabater-Lleal M, Chen Reef. of crustose coralline algae on the Great Barrier (2015) Distribution, abundance and diversity 2015. to UAS navigation. spired visual guidance:From insect homing baas CA, Kirin M, Lahti J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Ver UAS. navigationshot-based guidanceof forthe December 6-9, Zuhai,December 6-9, China. Biomimetics, and Robotics on Conference Human Molecular Genetics Australian Biochemist December 2015, Canberra,December 2015, Australia. Conference on Robotics and Automation 2-4 and oxidative stress in Alzheimer'sdisease. in stress oxidative and mitochondria of neurodegeneration—role ahead ofprint]. H, Hou B, Wang C, Zheng F, Zheng C, Wang B, Hou H, Psychiatry CHARGE consortium ( consortium CHARGE the in studies association genome-wide of in general cognitive function: a meta-analysis Marioni RE human cortical regionalization cortical human Jiang T dimorphic intra-ocular filter.intra-ocular dimorphic lanternfishes (Myctophidae): anovel sexually (2015) Spectral tuning in the eyes of deep-sea Marshall NJ, Clarke MW, Hahne D & Collin SP fies 18 new loci for fibrinogen concentration. identi individuals 120,246 of meta-analysis Cortex and Evolution A, Tang M, W, Steri TeumerJE, Huffman MH, Marioni RE Paper presented atthe Australasian Coral Reefs doi: 10.1093/cercor/bhv176 [Epub 10.1093/cercor/bhv176 doi: ] (2015) Genetic effects on fine-grained 20: 183-192. 20:183-192. ] Genetic contributions to variation Srinivasan MV. Srinivasan MV. Götz J(2015)Götz Dementia and 85:77-93. , Grossmann V,Grossmann , Paper presented at the IEEE Paper presented atthe IEEE 34: 581-594. 34:581-594. 46:4-7. N et al. =53 949). 25: 358-370 [Epub [Epub 25:358-370 (2015) [includes (2015) [includes . (2015). Brain, Behavior (2015) et al. et et al. . . Molecular Molecular [includes (2016) A Cerebral . . Bio-in- - Snap - - Dixon C , DSE, Dickins Denuelle A, Denuelle A, Dissel Dissel S, Angadi V, Dickins DSE, Dickins Dixon CL Denuelle A altered adults. inolder bilateral not in is stimulation motor cortices Plasticity induced by intermittent theta burst J, Klose M, Koch Z, English D,Winsky-Som English Z, Koch M, Klose J, F & F Srinivasan MV. ics, December 6-9, Zuhai,ics, December6-9, China. IEEE Conference on Robotics and Biomimet merer R, 323409. training with simple and complex tasks. is maintained in older adults after skilled motor manual transfer and bilateral plasticity cortical June, Denver, Colorado. on Unmanned Aircraft Systems (ICUAS), 9-12 ConferenceInternational the at presented door Environments. Snapshot-Based Control of UAS Hover in Out- for local homing of unmanned rotorcraft. unmanned of homing for local receptor subunits. defined combinations of GABA(A) or glycine of functional inhibitory synapses incorporating 3522-3536. 3522-3536. activity. on on presented at the 6th International Conference 17-19 Feb, Queenstown, NewZealand. roscience mutants. mutants. restores behavioral plasticity to restoresbehavioralplasticity tiers inAgingNeuroscience in unknown outdoor environments. outdoor in unknown spired visual stabilization ofarotorcraft UAV α1β2γ2 GABA (2015) Zolpidem andEszopiclone prime Automation, Robotics and Applications, and Robotics Automation, Srinivasan MV. , , Harrison NL, , & LynchZhang Y& (2015)Generation J , British Journal of Pharmacology Thurrowgood S van Swinderen B, & Srinivasan MV. R& Strydom Current Biology 8:80. & Kamke MR (2015) Inter Sale MV& , Kendoul F & F Kendoul Thurrowgood S, & Sale MV A Kirszenblat L receptors for longer duration (2015). Frontiers inMolecularNeu- Lynch Keramidas JW& A Paper presented atthe (2015) Neural Plasticity A view-based method method A view-based , Kamke MR(2015) Strydom R, Kendoul 25: 1270-1281. 25:1270-1281. et al. , , Suzuki Y, Donlea . . 7:73. Biologically-in (2015) Sleep (2015) Sleep Drosophila (2015). Paper Paper Paper 2015: 2015: Fron 172: 172: - - - - -
QBI publicationsQBI Fernell E, Bejerot S, Westerlund J, Miniscalco C, Faville R, FallDraK, T,Fischer R, Magi A, Ploner S, Hagg Fenlon LR, Duhig M, Patterson S, Connell M, Foley S, Capra C, Favre-Bulle IA, Preece D, Nieminen TA, Heap LA, Durschmid S, Zaehle T,Zaehle HJ, Heinze S, H, Durschmid Hinrichs Favre-Bulle I, Nieminen TA,NieminenD, LA, Favre-BullePreeceI, Heap Estrada-Mondragon & A vitamin D at birth: a sibling control study.control sibling a birth: at D vitamin low and disorder spectrum Autism (2015) Simila H risk factors. causal effects of adiposity on cardiovascular Reports entific Reports Molecular Autism focused beam in zebrafish brain tissue. Computational modeling of scattering of a Cerebral Cortex et al. disrupted disrupted in a mouse model of autism spec is cerebralcortex the in areas functional of RX Moldrich Dark F, Gordon A, Singh S, Hides L, trum disorder in MolecularNeuroscience Scott EK Scott & Rubinsztein-Dunlop H (2015) Scat Conference,April, Vancouver. 12-15 Sciences Life the in Optics the at presented with implications for optogenetics. tissue, brain intact in light sculpted of tering directly within the human nucleus accumbens. (2016) Sensory deviancy detection measured J, Voges childhood trauma in patients with early psy early with patients in trauma childhood chosis. of Psychiatry & Rubinsztein-Dunlop H. (2015). H. Rubinsztein-Dunlop & EK Scott sites in α1β2γ2L GABA(A) receptors. tional characterization of ivermectin binding understand sleep defects in your mutant sleep? Probing arousal to better does deeply How (2015) van Swinderen B Akerlund M, isma HH, Sarin AP, (2015) The prevalence and correlates of Liu S, Australian and New Zealand Journal Kottler B, 5: 11501. 5:11501. , , Dolan RJ & Knight RTKnight & RJ Dolan MI, Garrido , Gillberg C & Humble MB Humble & C GillbergEyles D, et al. et & Richards LJ(2015) Formation & Gobius I, Kurniawan ND, Diabetes 49:651-659. . Neural Development 5: 8454. 5:8454. 26: 1168-1175 [Epub 2015]. 2015]. [Epub 26:1168-1175 (2015) Age- and sex-specific 6:3. , Shaw PJ& Shaw Goodhill GJ, Benyamin B, Ladenvall C, 64: 1841-1852. 64:1841-1852. Lynch Func J(2015) 8:55. Drosophila McGrath JJ Murphy S, Scientific Scientific 10:10. Frontiers Paper Paper . Sci------,
Fogarty Fogarty MJ, Filmer HL, Dux PE & PE Dux HL, Filmer Foley DL, Mackinnon A, Morgan VA,GF,WattsMorgan A, Mackinnon DL, Foley hSOD1 synaptic excitation inthe presymptomatic dendritic regression, spine loss, and increased layerMotor V pyramidal cortex neurons exhibit eral sclerosis . Trends inNeurosciences and pathological brainnormal function. eral targeting in callosum of the corpus Fenlon LR ing stimuli. ing stimuli. cortex in the detection of single and compet reveal distinct functional roles for right parietal sociable effects of anodal and cathodal tDCS sample. psychosis andadultsinanationalcomparator with adults in associations factor risk cular Waterreus A & Galletly CA (2015) Cardiovas- Shaw JE, Magliano DJ, Castle DJ, 643-647. of Psychiatry G93A Australian andNewZealand Journal Noakes PG & Bellingham MC (2015) & mouse model of amyotrophic lat amyotrophic of model mouse Neuropsychologia Richards LJ 49: 714-723. 49:714-723. Journal of Neuroscience of Journal Mattingley JB (2015) Dis (2015) 38: 264-272. 74: 120-126. 74:120-126. C McGrath JJ, ontralat 35: - - - -
Galesloot TE, Janss LL, Burgess S, Kiemeney LA, Gazibara T, NJ, Elbert den Dekker HT, de Jongste Gazibara T, den Dekker HT, de Jongste JC, Jongste HT,de Dekker T, den Gazibara Gagnon YL Gibson G, Gibson Gehrman PR, Keenan BT,Keenan PR, Gehrman Gericke CA (2015) Ebola and ethics: autopsy of Garrison JR, Fernyhough C, McCarthy-Jones McCarthy-Jones C, Fernyhough JR, Garrison Garrido MI for translational medicine. translational for analysis locus trait quantitative Expression what do the genes say? and hepcidin as risk factors in atherosclerosis: Clinics of North America Clinics ofNorth Biology den Heijer M, de Graaf J, Holewijn S, Image Tiemeier Tiemeier H, Jaddoe VW, JC, Reiss I, [Epub2015]. 337-346 cine McGrath JJ, . . signal inmantisshrimps nication (2015)Circularly polarized lightasacommu (2015) Genetics of sleep disorders. doi: 10.1111/pai.12530 [Epub ahead of print]. a failure. tion RStudy tion D levels with childhood eczema. The Genera tions of maternal and fetal 25-hydroxyvitamin Study R Generation the asthma: and function lung childhood with levels D 25-hydroxyvitamin fetal and maternal of Associations (2016) brain. associated with hallucinations in the human (2015)ParacingulateJS is morphology sulcus B] Research Mowry [includes Bank & Simons AustralianM, HaggardThe SchizophreniaS, Whitfield JB, Swinkels DW, Swinkels JB, Whitfield induced by mismatchcomputations cortex drives hippocampal theta oscillations Ventromedialprefrontal (2015) RJ Dolan & Franco OH, Tiemeier H, Jaddoe VW,Jaddoe H, Tiemeier OH, Franco . 7:60. . . Nature Communications 120: 362-370. 362-370. 120: Clinical and Experimental Allergy 25: 3074-3078. 25:3074-3078. , , Barnes GR, Kumaran D, Maguire EA Powell JE Templin RM British Medical Journal Medical British McGrath JJ, . Pediatric Allergy and Immunology Pediatric Allergy and Immunology Eyles DW & Marigorta UM (2015) UM Marigorta & , How MJ & BMC Genetics & Pack AI Pack & Byrne EM et al. et Eyles DW, , 38: 667-681. 38:667-681. Burne TH et al. (2015)Associa Genome Medi Genome 6: 8956. 6:8956. . 350:h2105. Marshall NJ (2015)Iron Benyamin B, Psychiatric Psychiatric Burne TH, , Reiss I, Reiss , . Current 16:79. Neuro- et al. et 46: - - - -
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Jouir T, Jackson J, Huang Huang J, Howie B, S, McCarthy Memari Y, Walter K, Huffman JE, de Vries PS, Morrison AC, Sabat AC, Morrison PS, Vries de JE, Huffman Johnson BP, Pinar A, Fornito A, A, FornitoBP, A, Johnson Pinar Jensen CB, Gamborg M, Raymond K, Howrigan DP, Simonson MA, Davies G, HarrisDP, G, Howrigan Davies MA, Simonson Ittner L, Halliday G, Kril J, J, Kril G, Halliday L, Ittner UAV attitude. sky compassto achieve robust estimationof 2-4 December2015, Canberra, Australia. sian Conference on Robotics and Automation, sis fusion pore and vesicle release. exocyto the of regulatorbi-directional a as dynamin of role the demonstrate molecules key A, Robinson PJ & Keating DJ (2015) Small levels of fibrinogen, FVII, FVIII, and vWF. plasma with association their and variants Marioni RE Early HumanDevelopment H-F, Min JL, Danecek P, Malerba G, Trabetti E, Zheng ahead ofprint]. [Epub mp.2015.120 Chasman DI, Chen M-H, Guo X, KacprowskiT, M, JA,er-Lleal Brody PL, Auer ropsychologia ability sity is associated with lower general cognitive Visscher PM] (2015) Genome-wide autozygo reaction time variability in healthy adults. rior cingulate activity predicts intra-individual ante Left (2015) MA Bellgrove & R Hester Reviews Neurology trends in seasonal variation in birth weight. birth in variation seasonal in trends Secular (2015) BL Heitmann & SorensenTI IJ, Deary DC, Liewald JM, Starr TenesaA, SE, mouse studies into studies mouse trials clinical translating - ALS and FTD (2015) M Kiernan 126: e19-e29. Psychiatry erence panel. and rare variants using the UK10K haplotype ref (2015) Improved imputation of low-frequency , Wright MJ, et MJ, Wright McRae A, et al. & Srinivasan MV. R& Strydom . . Molecular Psychiatry Papadopulos A, & [includes PM Visscher 20: 810-819. 20:810-819. ] (2015) Rare and low-frequency and Rare (2015) ] Paper presented Australa the at Nature Communications 72:22-26. 11: 360-366. 11:360-366. Götz J Meunier FA, McClus 91: 361-365. 91:361-365. doi: 10.1038/ doi: et al. , Hodges J & J Hodges , al. Nandam LS, . (2015) McGrath J, [includes Molecular Molecular [includes [includes . . 6: 8111. Yang J] Nature Blood - Neu A 3D A 3D ------
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QBI publicationsQBI Lee BK & BK Lee Lee SH Kenna TJ,Kenna Lee JY,Lee JD,S, Lee Phipps Klenowski PM, Fogarty MJ, Belmer A, , Nedelska Z, Fripp J, Laczo J, Laczo J, Fripp Z, Nedelska Kerbler GM, Keshavarzi S, Kozulin P, Larkin A, (2016). Investigating early formation of the cere of Neuroscience equilibrium SNP simulation. simulation. SNP equilibrium in rexin-1 regulates sleepandsynapticplasticity in AgingNeuroscience Journal ofNeuroinflammation Trends inMolecularMedicine Journal ofNeuroscience Rheumatology the pathogenesis of ankylosing spondylitis. ankylosing of pathogenesis the reticulumEndoplasmic in aminopeptidases Postnatal Development of Determinants 4 (TLR4) extends survival in the hSOD1 the in survival extends (TLR4) 4 receptortoll-like of Absence (2015) TM ruff interneurons and principal cells inthe rat baso GABAergic and arbors on inputs synaptic dendritic characterizationof functional and Bellingham MC & SE Bartlett (2015) Structural lateral amygdala contributes to allocentric navigation impair navigation allocentric to contributes J & Hort S, Rose AS, Hamlin J, Lisy M, Vyhnalek ment inAlzheimer’s diseasepatients. . 112: E5449-E5451 mouse model of amyotrophic lateral sclerosis. and protocols. In DW Walker (Ed.), bybral inutero electroporation: cortex Methods . 114: 942-957 tal age and autism: multifactorial pathways.multifactorial autism: and age tal the National Academy of Sciences of the USA 3-20). NewYork: Humana Press [Epub2015]. olfactory inputs to medial amygdala neurons. & RK Claudianos C Claudianos van Swinderen (2015) B& Neu Drosophila melanogaster Coulson EJ Coulson (2015) Basal forebrain atrophy (2015) Implications of simplified linkage (2015) Dendritic organizationof Dendritic (2015) Sah P McGrathAdvancingparen(2015) JJ Chen MY, Almarza G, & Haroon N (2015) N Haroon & Robinson PC Power JM, 54: 1549-1556. 54:1549-1556. . 42: 2455-2466. 42:2455-2466. Journal ofNeurophysiology Kirszenblat L Gobius I 7:185. & Wood & Noakes PG Albers EH, 35: 13020-13028. 35:13020-13028. . European Journal European Journal & Proceedings of 21: 118-125. 21:118-125. 12:90. Richards LJ. , Prenatal and Prenatal and Reinhard J, Noakes PG, Frontiers Frontiers Sullivan . (pp. G93A ------
Lefevre EM, Lee SH, Leung LC,Leung WA,Harris & CE Holt dose-dependent and independent of environ is MK-801 to sensitisation Behavioural Journal ofEpidemiology . context mental Trends inNeurosciences The yin and yang of sleep and attention. Kirszenblat L T, Gusev A, Hu X, Vinkhuyzen AA, Ripke S, Andreassen OA, Frisell system. visual developing the in behaviour axon cell ganglion retinal regulates Nf-protocadherin . 298: 241-245 . . nia and rheumatoid arthritis the negative association between schizophre & McGrath JJ, Wray NR] (2015) New data and an old puzzle: , Hultman CM, Kahler A, Kahler CM, Hultman Byrne EM , PLoS ONE Eyles DW & Mehta D, et al. BehaviouralBrainResearch van Swinderen B 10:e0141290. [includes MantziorisVX, [includes & Zhao Q Zhao . 44:1706-1721. 38: 776-786. Burne TH Piper M(2015) International , Mowry BJ Mowry (2015) (2015) - -
Litvak V, Li J, Liu B, Chen C, Cui Y, Shang L, Zhang Y, Wang Linneberg A, Jacobsen RK, Skaaby T, Taylor AE, Lim JW, Li J, Cui Y, Wu K, Liu B, Zhang Y, Wang C & Locke AE, Kahali B, Berndt SI, Justice AE, Pers AE, Justice SI, Berndt B, Kahali AE, Locke Li QJ, Song M, Fan LZ, Liu Y & Y Liu FanLZ, M, Song QJ, Li Lin MH, Apolloni A, Cutillas V, Cutillas A, Apolloni H,Sivakumaran MH, Lin in Neuroanatomy transcription complex reverse transcription by targeting the reverse ogy. mass index yield new insights for obesity biol Visscher PM] (2015) Genetic studies of body vascular Genetics C, Zhang X, He Q, Zhang W,Zhang Q, He X, Zhang C, et al. and working memory. prefrontal morphology, functional connectivity, of the mouse anterior cingulate cortex. (2015) EMX1 regulates NRP1-mediated wiring Asvold BO, Gabrielsen ME, Campbell A, JH, Bjorngaard JL, Jeppesen ME, Fluharty 4827-4836. Gobius I Fenlon LR , Jiang T](2015) novelty seeking. of effect the mediates (2015) The cortical surface area of the insula ML, ML, TH, Day FR, Powell C, Vedantam S, Buchkovich roscience based based on local connectivity profiles. cerebral cortices primary the Parcellationof 36: 4372-4382. 36: 4372-4382. the CARTA . consortium Mendelian randomisation meta-analysis in rate: pressure blood on A resting and heart [includes Marioni RE opment Martin S Martin reproducibility study a studies: (DCM) group for Bayes Empirical Yang J, (2015) A mutant tat protein inhibitsHIV-1 Nature Garrido M Donahoo AL, , 142: 3746-3757. 142: et al. , Li D, Wei T, Wang R, Jin H, Spann K, 9:670. Liu Y, Zhou J, 518: 197-206. 197-206. 518: et al. et [includes Richards Wray LJ] NR& RAB2A , Zeidman P & Friston K (2015) NeuroImage & Vinkhuyzen [includes AA& 9:50. 8: 832-841. 8:832-841. . ] (2015) Effect of smoking Frontiers Neu- inHuman . Polymorphism impacts Polymorphism impacts Human Brain Mapping , Bunt J, Journal ofVirology Moldrich RX, DBH Circulation: Cardio- Jiang TZ(2015) rs7040170on et al. 117: 184-190. 117: Edwards TJ, [includes Frontiers Piper M, Jiang T Devel et al. 89: 89: - -
Luciano M, Svinti V, A, Svinti Campbell M, Luciano Loh PR, Bhatia G, Gusev A, Finucane HK, Bulik-Sul Luciano M, Pujals AMF,Pujals M, Luciano Maier R, M, Luciano al. diction of cognitive abilities. cognitive of diction Structural brain MRI trait polygenic score pre in younger andolderadults. and their interaction on cognitive performance DJ, Thomson P, Prendergast JGD, AF,Wright C, Hayward Taylor Porteous MS, Lee SH Visscher PM tium [includes Gratten J Consor Genomic Psychiatric the of Group WorkingSchizophrenia SJ, Pollack BK, livan ance-components analysis. vari fast using diseases complex other and schizophrenia of architectures genetic and HumanGenetics versus lifetime depression, lifetime versus Current (2015) IJ Deary & AM McIntosh DJ, Porteous DJ, MacIntyre C, Hayward A, JB, Scheftner WA, Shi J, Weissman MM, Weissman J, Shi WA, Scheftner JB, Visscher PM& BJ, [includes Mowry Genomics Consortium Psychiatric the of Group Working order 96: 283-294. 18: 117-125. 47: 1385-1392. G, Bis JC, Debette S, DeCarli C, DeCarli S, Debette JC, Bis G, Maniega SM, Hamilton IF, Royle NA, Chauhan order. dis depressivedisorder, major bipolar and accuracy of risk prediction for schizophrenia, increasesdisorders psychiatric of analysis Medicine study associated with general cognitive ability: a pilot variantsrare detect to sequencing Exome [includes Wray [includes NR . . Moser G, Moser American Journal of Human Genetics Twin Research and Human Genetics Human and TwinResearch , , Wray NR, Marioni RE 77: 480-492. 77:480-492. QBI publicationsQBI , & , ], Coryell W, Wray Coryell Potash NR], Chen GB, Ripke S, Cross-Dis Mowry BJ Mowry Queensland Brain Institute et al. et , Valdés Hernández M, HernándezValdés , & Lee SH & 18: 738-745. 18:738-745. Marioni RE (2015) Contrasting (2015) , Annual Report 2015 Annual Report Lee SH ], de Candia TR,Candia de ], Nature Genetics APOE Psychosomatic TwinResearch P ] (2015) Joint Joint ] (2015) C UBLI Marioni RE et al. et al. , Campbell , , variation, Wray NR, (2015) (2015) (2015) ATIONS et et ------,
86 Publications Publications QBI publicationsQBI QBI ANNUAL REPORT 2015 , Campbell A, Scotland G, Hayward C, C, Hayward G, Scotland A, Campbell RE, Marioni Marioni RE, Marioni Marioni RE, Marioni cognitive ability across the life-course. the across ability cognitive & Visscher PM zebrafish.in connection Topographic wiring of the retinotectal Kita EM 1936. 1936. Cohort Birth Lothian the in fitness cognitive and physical with correlated is clock netic of the of Porteous DJ & Deary IJ (2015) Differential effects Muniz-Terrera G, Harris SE, Gibson J, Red J, Gibson SE, Muniz-TerreraHarris G, mond P, Cox SR, Pattie A, Pattie P,SR, mond Cox ogy 44: 1388-1396. 44: 1388-1396. ejhg.2015.210 [Epubaheadofprint]. Neurobiology pean Journal of Human Genetics all-cause mortality in all-cause later mortality life. (2015) DNA methylation age of blood predicts Cox SR, E, Harris SE, Gibson J, Henders AK, Redmond P, 16:25. International JournalInternational ofEpidemiology APOE et al. , Shah S, S Shah S, cott EK & & Wray [includes Visscher NR ] PM & e4 allele on different domains of of domains different on allele e4 75: 542-556. Wray NR] (2015) The epige McRae AF, McRae Chen BH, Colicino , Ritchie SJ, Ritchie AF , McRae Goodhill GJ Developmental et al. et Genome Biol doi: 10.1038/ (2015) [includes Euro - - - -
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QBI publicationsQBI Nelson EC, Agrawal A, Heath AC, Bogdan R, Bogdan AC, Heath A, Agrawal EC, Nelson Network Pathway Analysis Subgroup of the of Subgroup Analysis Pathway Network Narayana VK Chou Chou YL, Demers CH, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Lee SH, [includes Psychiatric Genomics Consortium 10.1038/mp.2015.102 [Epub ahead of print]. 219-222. Chemistry andBiology Chemistry of the apoptotic pathway. erative axonal requires fusion components Hilliard MA Linton C Neumann B (2015) Evidence of Evidence (2015) roscience opioid dependence immune immune and histone pathways. association study analyses implicate neuronal, & for saturated fatty acids in neuroexocytosis. using stable isotope tagging uncovers a role Meunier FA (2015) Profiling of free fatty acids Wray NR] (2015) Psychiatric genome-wide , Lee E Mowry BJ, Mowry , , 18: 199-209. 18:199-209. Tomatis VM, (2015) E , Coakley S S , Nakagawa A, Xue . Molecular Psychiatry FF CNIH3 Byrne E, et al. et , Giordano-Santini R -1-mediated regen-1-mediated 22: 1552-1561. 22:1552-1561. Wang T [includes Wray [includes NR] involvement in involvement Nature Visscher PM , , & Kvaskoff D& Nature Neu- 517: D & doi: doi: - ,
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88 Publications Publications QBI publicationsQBI QBI ANNUAL REPORT 2015 Robinson PC Robinson Robinson PC Robinson Robinson PC, Costello M-E, Leo P, Bradbury LA, Robinson MR, Reuter E-M , Robinson Robinson GA, Spooner D & Robinson PC Robinson Robinson PC & Merriman TR (2015) Does midlife Cremin K, Bradbury LA, Stebbings S, Harri S, Stebbings LA, Bradbury K, Cremin of theRheumaticDiseases and assessment inAnkylosing Spondylitis . Weisman M, S-C, Shim KB, Joo S, Lee A, Cortes K, Hollis Brain Research and body mass index across Europe height of differentiation genetic Population Vinkhuyzen A T,Esko M, zavilla lum stress markers. inflammatory cytokines or endoplasmic reticu HLA-B27, or chains heavy surface alter not Diseases Genetics ERAP2 Sciences oftheUSA Proceedings oftheNational Academy of tor adaptation: an SSVEP study Reliance on visual attention during visuomo thoughts. novel of sequencing fluent and generation between Distinguishing palsy: supranuclear progressive in aphasia dynamic Frontal betes &Endocrinology al. ankylosing spondylitis. uveitis and their overlap with the genetics of anterior acute of associations genetic The with ankylosing spondylitis in spondylitis ankylosing with GP, Bradbury LA, Brown MA & Kenna TJ (2015) obesity really lower dementia risk? 2015]. [Epub 17: 46-51 son AA, Evans DM, Duncan EL, Duncan DM, Evans AA, son itive and itive [includes Yang& J functional knockout in humans does 47:1357-1361. HLA-B27 74: 2092-2095. 74:2092-2095. & Bednark J & Brown MA (2015) ERAP1 biology Neuropsychologia , Lau E, Keith P,Keith E, Lau , Thomas MC, Lau Hemani G, Medina-Gomez C, Mez , Leo PJ, Pointon JJ, Harris J, Harris JJ, PJ,Pointon Leo , et al. , Berndt SI, Gustafsson S, Gustafsson SI, Berndt , 233: 2041-2051. 2041-2051. 233: (2015) Shakhbazov K -negative patients. patients. -negative Annals of the Rheumatic 112: E1816. 112: 3:501. Visscher PM] (2015) Cunnington R(2015) Genes and Immunity Harrison WJ (2015) ERAP2 74:1627-1629. 77:62-75. HLA-B27 . is associated isassociated Experimental Experimental et al. , Lancet Dia- Powell JE . (2016) Annals Nature -pos- et et - - - - ,
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Tsuyama J, TsuyamaJ, Thompson PM, Andreassen OA, Arias-Vasquez A, TeplitskyC, Upton KR, Gerhardt DJ, Jesuadian JS, Richardson UK10K UK10K Consortium [includes Tropf FC, Stulp G, Barban N, Tong J, Mckinley L-A, Cummins TDR, Johnson TDR, Cummins L-A, MckinleyTong J, J, Chang-Claude U, AP,Peters Thrift J, Gong brain in 35 countries worldwide. the individual: Predicting factors that affect the stem cells. acquisition of gliogenic competence by neural Okano H (2015) MicroRNA-153 regulates the &Y,T, T Hamakubo Mochizuki Shimazaki DM, Cannon KB, Bulaeva JK, Buitelaar RL, Bearden CE, Boedhoe PS, Brouwer RM, Buckner University Press. the Wild the ity disorder hyperactiv- deficit attention with associated novel dopamine beta hydroxylase gene variant a of characterisation functional and cation LEB Kruuk (Eds.), Kruuk LEB Charmantier,&GarantA D In populations. Evolutionary potential and constraints in wild al. Brennan PM, Brennan MS, Knaap der van C, Salvador-Palomeque SR, Sanchez-Luque FJ, Bodea GO, Ewing AD, . disease and health in ants (2015) The UK10K project identifies rare vari pal neurons. (2015) Ubiquitous L1 mosaicism in hippocam Psychiatry modern societies. in selection natural and genetics, molecular Snieder H & Mills MC (2015) Human fertility, Kent L, Bellgrove MA, MA, Bellgrove L, Kent B, 44: 662-672. AR, Rudolph A, Slattery ML, Chan AT, Esko T, Wood ahead ofprint]. doi: 10.1016/j.neuroimage.2015.11.057 [Epub cancer colorectal of risk and height of study ization ] (2015) ENIGMA and and ENIGMA (2015) [includesWright MJ] , Vance A, Heussler H, Gill M, Gill H, Heussler A, Vance Matthews N, Yang J, . International Journal ofEpidemiology (pp. 190-208). New York: OxfordYork: New 190-208). (pp. & Merila J. (2014). J. Merila & MR Robinson , Bunt J, 16: 610-618. 16:610-618. . Stem CellReports et al. The World Journal of Biological Cell et al. 161: 228-239. 228-239. 161: (2015) Mendelian random (2015)Mendelian - PLoS ONE Quantitative Genetics in , Iwanari H, Iwanari Richards LJ, [includes et al. & Yang J] PM& Visscher Visscher PM , Nature (2015) Identifi (2015) 10: e0126821. 10:e0126821. 5: 365-377. 5:365-377. Faulkner GJ] NeuroImage . 526:82-89. Yang J et et - - - ,
Vidovic D, Harris L, Harvey T,Harvey L, D,VidovicYH, Harris Heng Evelyn van der Linden S, Akkoc N, Brown MA, Vieth HE, McMahon KL, McMahon HE, Vieth Vilhjalmsson BJ, Vilhjalmsson Van De Poll MN, Vinkhuyzen AAE Wang C, Liu B, Long H, Fan L, Li J, Zhang X, Qiu C, Behavioural and fMRI evidence. fMRI Behaviouraland production: word spoken in relations part Zubicaray GI (2015) Interference from object Smith Smith A, Osinski J, Hughes J, Thomas P, Gron NFIX. NFIX. evident in mice lacking the transcription factor ependymal deficits underlie the hydrocephalus (2015) Expansion of the lateral ventricles and Bhatia G, Do R, Do G, Bhatia A, Lindstrom S, Ripke S, Genovese G, Loh PR, Neuroscience American JournalofHumanGenetics erences inhoneybees . to explore choice behaviour: visual flicker pref reality virtual in geometry abstract an Using & Srinivasan MV Neurolinguistics bloods: the Generationbloods: the R Study on maternalmid-gestationandneonatalcord and predictors of vitamin D deficiency based Tiemeier H & F,VW,Verhulst Jaddoe CJ, Kruithof LME, 576-592. BDNF and COMT on the frontostriatal system. Yu C & doi: 10.1016/j.jsbmb.2015.09.018 [In press]. Biology Steroid Biochemistry and Molecular Biology Steroid andMolecular Biochemistry ostajski ostajski RM, Bailey TL, matology Reports proposals for a way forward. way a for proposals spondyloarthritis: Strengths, weaknesses, and & Khan MA (2015) The ASAS criteria for axial increases accuracy of polygenic risk scores. disequilibrium linkage Modeling (2015) Brain Research Jiang T (2015) Epistatic interaction of 218: 3448-3460. 3448-3460. 218: McGrath JJ 298: 380-388. 380-388. 298: , Zajaczkowski EL, , Finucane HK, Gusev HK, YangFinucane J, Eyles DW et al. 36:56-71. 17:62. van Swinderen B(2015) [includes Visscher PM] [includes 1616: 71-87. 1616: Journal of Experimental Journal ofExperimental et al. Cunnington R , (2015) Prevalence Burne TH [includes PiperM] Current Rheu Current Robinson PC Robinson . . Journal of Journal of Taylor GJ, , Blanken & de & 97: - - -
Wang J, Fan L, Wang Y,Wang L, Fan W, J, WangXu T, Jiang PT,Fox Wang J, Tian Y, Wang M, Cao L, Wu H, Zhang Y,Zhang H, Y,Wu Tian L, J, Wang Cao M, Wang Whelan Whelan CD, Hibar DP, van Velzen LS, Zannas AS, Wang T, Wang J & Westcott C, Waghorn G, McLean D, Statham D & Wang H, Kurniawati H, Westcott C, Waghorn G, McLean D,D McLean Statham G, Waghorn C, Westcott Psychiatric Rehabilitation Eickhoff SB, Yu C & YuC SB, Eickhoff Israel.Scheduling, 7-11June,Jerusalem, and Planning Automated on Conference Twenty-FifthInternationalthe at presented Occupational Therapy network for visuospatial attention and neglect. Wang K & Press.China: CRC formation subregions. automatically hippocampal human segmented Wright MJ] (2016) Heritability and reliability of and Bioengineering Faskowitz J, deZubiracayG, J, Faskowitz Carrillo-Roa T, McMahon K, Prasad G, Kelly S, er-White JJ, Sibarita JB, Choquet D, Choquet JB, Sibarita JJ, er-White Coop NR, MavlyutovD,TA,Niranjan Glass s11682-015-9460-y [Epubaheadofprint]. Brain Imaging and Behavior an application of planning inethology. ofplanning application an 137 [Epub 2015] 137 [Epub2015] closed. In M Wang (Ed.),Wang M In closed. connectivity patterns of V1 with eyes open and people with schizophrenia. Interest B(2015) employment in among Mowry 35: 6179-6194. [includes (2015) adults with schizophrenia. & files. pro connectivity multimodal on based area nation of the posterior boundary of Wernicke’s neurotoxin A. type presynaptic activity unveiled using botulinum by retrogradeflux axonal autophagosome Mowry B Mowry Human Brain Mapping Martin S, Martin . . Jiang T. (2015). Changes of functional In-silico behavior discovery system: Jiang T (2015) A lateralized top-down Meunier FA (2015) Role functioning among functioning Role (2015) QBI publicationsQBI Papadopulos A, Queensland Brain Institute Journal ofNeuroscience (pp. 697-700). Kunming, & Srinivasan. M Singh S& Jiang T(2015)Determi- 78: 158-165. 78:158-165. NeuroImage ] (2015) Control of Control (2015) ] . 18:187-207. American Journal of American Journalof Medicine Sciences Annual Report 2015 Annual Report British Journal of British 36:1908-1924. et al. doi: 10.1007/ doi: P C UBLI Harper CB, [includes 128:125- Paper ATIONS et al. - -
Publications Publications QBI publicationsQBI QBI ANNUAL REPORT 2015 Wong SY, Ulrich TA, Deleyrolle LP, MacKay JL, Lin , Widagdo J, Xia D Winkler TW, Justice AE, Graff M, Barata L, Fei L, Barata M, Graff AE, TW, Winkler Justice & Anggono V J& Widagdo (2015) Ubiquitin signals , Reutens DC & Hocking J (2015) J Hocking & DC Reutens Williams RJ, & Wray NR Xie S, Zuo N, Shang L, Song M, FanM, Song ZuoL, S, Shang Xie N, & L Windels F JM, Martuscello RT,JM, Martuscello Jundi MA, Reports 15718-15719. 15718-15719. The influence of age and sex on genetic asso large-scale genome-wide interaction study.interaction genome-wide large-scale A shape: and size body adult with ciations dritic spines. microtubule-associated protein Tau to den the targets mutation P301L the of presence the or epitopes distinct Tauat of rylation Kilpelainen TO, T,Esko MF,tosaJ, Czajkowski S, FallT,Chu PLoS ONE Breeding andGenetics PLoS Genetics the demise of AMPA receptors. diffusion-weighted diffusion-weighted fMRI. center by decreased water displacement using color human the of localization Functional genetics of disease traits. Research inputs and reduces tissue invasion. tissue reduces and inputs glioma tumor-initiating cells to mechanical myosin-dependent contractility sensitizes of activation Constitutive (2015) S Kumar & (2015) How does B-value affect HARDI recon . 1852: 913-924 its role inlocomotion? (2015) Where and what is the PPN and what is 5: e00408. struction using clinical diffusion MRI data? MRI diffusion clinical using struction intracellular sorting andintracellular degradation sorting . GluA1 and GluA2 regulates AMPA receptor of ubiquitination Activity-dependent (2015) RC, son , & Li C , Thevathasan W,Thevathasan , 10:783-795. Chai YJ , , Huganir RL & RL Huganir Sah P, (2015) Quantitative (2015) Visscher PM 75: 1113-1122. 75:1113-1122. 10: e0120773. 10:e0120773. Götz J Biochimica et Biophysica Acta et Biophysica Biochimica 11: e1005378. 11:e1005378. et al. , Ridder MC, (2015)Pseudophospho [includes Yang J Brain 132: 198-203. 198-203. 132: Brain andBehavior & P Silburn Journal of Animal 138:1133-1134. Chau YQ , John Oncotarget Reynolds BA Anggono V Jiang T ] (2015) ] (2015) Cancer Sah P Cell 6: 6: ------
Xie TY, Xu J, Wang J, Fan L, Li H, Zhang W, Hu Q & Yang J, Yang J, Xu J, Rosoff WJ, Urbach JS & Yang X, Yang Z, Yang Yang Y, Fan L, Chu C, Zhuo J, Wang J, Fox PT, Eick J, Chen C, Chen J, LK, Tschop M, Waters MJ, Tolle V, Epelbaum height andbodymassindex. human for populations and sexes between homogeneity genetic Genome-wide (2015) of Neuroendocrinology Esko T, Milani L, Nolte IM, van Vliet-Ostaptchouk JV, Snieder H, release of growth hormone in mice. in hormone growth of release pulsatile the on ghrelin-o-acyltransferase Frontiers inNeurology NeuroImage Vliet-Ostaptchouk Vliet-Ostaptchouk JV, Lee SH [Correction]. term response of axons to molecular gradients Adaptation is not required to explain the long- national JournalofComputerVision stationary stationary velocity field parameterization. using mapping landmark metric feomorphic ular Genetics Reports resonance imaging and machine learning magnetic functional resting-state on based (2015) Lateralization of temporal lobe epilepsy mass index. missing heritability for human height and body mation with imputed variants finds negligible & alytic activation modeling-based parcellation. subdivisions in the human brain using meta-an hoff SB & the human middle temporal middle human the gyrus Tractography-based(2015) of parcellation Visscher PM] Visscher (2015) Genetic variance esti , Bakshi A, , Bakshi A, Ngo ST, Veldhuis JD, Jeffery PL, Chopin , Reutens D & D Reutens Li Y, Choupan J , Robinson MR, Robinson Perry JR, Nolte IM, van 5:18883. Jiang T et al. 124:300-309[Epub2015]. Nature Genetics Development , Zhu Z, , Zhu Z, 24:7445-7449. (2015) Effect of deletion of deletion of Effect (2015) et al. (2016) Identifying functional , Reutens D & Hocking J Hocking & D Reutens , , Hemani G, , Hemani G, [includesVisscher PM] et al. et 6:184. 27: 872-886. 27:872-886. Jiang T (2015) Goodhill GJ(2015) [includes Wray [includes NR 142: 2385. 142: 47:1114-1120. Human Molec Vinkhuyzen AA, Vinkhuyzen AA, (2015) Dif (2015) 115:69-86. . Scientific Scientific Journal Jiang T Inter------.
Zhang CR, Ho MF, , OH Zalucki Menon H, Zannas Zannas AS, Arloth J, Carrillo-Roa T, Iurato S, Roh Zalesky A, Pantelis C, Cropley V, Fornito A,V, Fornito Cropley C, Pantelis A, Zalesky Yu H, Wang L, Lv L, Ma C, Du B, Lu T, Jin C, Yan H, Zhang X, Li J, Qin W, Yu C, Liu B & Zalucki O, functional network centrality of the parahip the of centrality network functional polymorphism modulatesthe intrinsic relevance of glucocorticoid signaling. cohort: American African urban, an in aging (2015) Lifetime stress accelerates epigenetic Biology chotic medications. antipsy atypical of effects gain weight with B, Heim C, S, Ressler KJ, Nemeroff CB, Smith AK, Bradley nogaster siblings. cents with schizophrenia and their unaffected development of brain connectivity in adoles- Delayed(2015) N Gogtay & JL D,Rapoport L, McAdams Cocchi H, L, Clasen Greenstein 10.1093/schbul/sbv179 [Epub ahead of print]. Yang Y, Li W, Reports in 3 backgroundstrainsof 3 in trophysiological analysis of general anesthesia van Swinderen B (2015) Behavioral and elec The catechol-o-methyltransferaseThe Val 8: 40. . 122: 1060-1074 the the suggested study association Genome-wide pocampal cortex pocampal in cortex healthy subjects. 467b-5p levels. 467b-5p miR- and trimethylation H3K4 methylation, with concomitant changes in promoter DNA alters adult hippocampal VGLUT2 expression & Chong S (2015) Prenatal ethanol exposure in in resistance and hypersensitivity to isoflurane van Swinderen B(2015)Syntaxin1A-mediated & S Karunanithi N, Lavidis ATBademosi , Drosophila melanogaster PTPRD 16:266. 5: 10105. 5:10105. Day R, JAMA Psychiatry . Fly et al. polymorphisms were associated et al. 9:7-15. [includes Wray D ] Mehta NR& Sanchez Vega MC, Epigenetics and Chromatin , Karunanithi S & S Karunanithi Kottler B, ] (2015) B](2015) [includesMowry Kottler B, Schizophrenia Bulletin 72:900-908. Drosophila mela- . Faville R, Anesthesiology Jiang T Burne TH Scientific Scientific Genome Genome (2015) (2015) 158 Day R, Met doi: doi: - - -
Zhou Zhou B, Osinski JM, Mateo JL, B, Martynoga Sim Zhang X, Yu J, Zhao R, Xu W, Niu H, Zhang Y,Zhang H, W,XuNiu R, Zhao J, Yu X, Zhang Zhou Y, Fan L, Qiu C & Zhang Zhang X, Yu JT, Li J, Wang C, Tan L, Liu B & Zhu Z, Zuo N, Song M, Fan L, Eickhoff SB & SB Eickhoff L, Fan M, Song N, Zuo Zhang Y-q, Yong L, Chun-shui Y & u H G Z, Gu H, Zuo Snieder H, LifeLines Cohort Study, LifeLinesH, Snieder Cohort Esko T, JV, Vliet-Ostaptchouk van IM, Nolte Lee SH , ogy healthy individuals. volume and functional connectivity in young hippocampalmemory, working on effects Science Optics cells cells towards oligodendrogenesis. factor biases postnatal neural stem/progenitor ostajski RM (2015) Loss of NFIX transcription FJ, Campbell CE, Guillemot F, wavelet coherence. wavelet bynear-infraredspectroscopy functional in Zuo N & of schizophrenia. of hypothesis dysconnectivity the and cortex and Development (2015) Bridging integrator Bridging (2015) ( 1 state functional MRI. functional state resting by revealed network mode default the for modes interactionDifferent (2016) 207-219. Neuroscience Wang(Ed.), nal in cortex mild cognitive impairment. In M al. . nanoparticles and redispersity of layered double hydroxide Crosslinking to enhance colloidal stability 96: 377-385. neering traits. to the missing heritability for human complex Dominance genetic variation contributes little Altered functional connectivity of the entorhi- & [includes Visscher PM 40:1794-1803. Bakshi A, American Journal of Human Genetics 20: 016004. 20:016004. (pp. 143-147). London: CRC Press. London:CRC (pp.143-147). 459: 10-16. 459: Jiang T (2015) Activation detection - Medicine SciencesandBioengi X Z (2015) ZP Xu & Cooper H 43: 78-88 [Epub 2015]. [Epub 43:78-88 Journal of Colloid and Interface Interface ofColloidand Journal Vinkhuyzen AA, 24: 2114-2126. 24:2114-2126. Neuroscience Bulletin Jiang T Neuropsychopharmacol- Journal ofBiomedical European Journal of (2015) Prefrontal & Gron Piper M& BIN1 Yang J] (2015) Jiang T Hemani G, ) genotype ) genotype Stem Cells Cells Stem Jiang T . (2015). Jiang T 31: et -
Journal editorial boards editorial Journal Professsor RossC Professsor ElizabethC H Associate Professsor Thomas Burne Associate Professsor D Professsor Bartlett Perry D • • • • • • • • • • • • • • • • •
r Timothy Bredy r Timothy r elen Neuropsychologia PLOS ONE Journal ofNeurochemistry Growth Factors PLOS ONE Frontiers inBiology Yonsei MedicalJournal Stem CellResearch Neurosignals Neural Development Journal ofNeuroscience Research Neuroscience International Journal ofDevelopmental IBRO Reports Associate Editor Frontiers inNeurogenesis Developmental Neurobiology Acta PhysiologicaSinica Insights inCellScience Editorial Board Editorial Board Editorial Board V ictor Anggono C ooper , Editorial Board , Academic Editor , Editorial Board , International Editorial Board , Editorial Board , Editorial Board , Editorial Board , Editorial Board , Editorial Board , Editorial Board , Editorial Board , Editorial Board , Editorial Board unnington ,
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, , , Professsor D Professsor • • • • • • • • • • • • • • • • • • • r Michael Piper Associate Editor BMC Neuroscience Translational Psychiatry Stress, Brain, &Behavior Schizophrenia Research Schizophrenia Bulletin Editorial Board Revista Brasileira dePsiquiatria Frontiers inMolecularPsychiatry Epidemiology andPsychiatric Science Related Psychoses Clinical Schizophrenia and BioMedCentral Psychiatry of Psychiatry Australian andNewZealand Journal Acta Psychiatrica Scandinavica Science ofLearning Journal(npj) Nature Partner Neuroscience Research Neuropsychologia Neurocase Cortex Cognitive Neuroscience Brain andCognition Editorial Board Advisory Editorial Board Editorial Board , Associate Editor , Editorial Board , Editorial Board J J ason Mattingley ohn McG , , Editorial Board
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, , Journal editorial boards editorial Journal Professsor NaomiWray Professsor Mandyam Professsor Professsor Pankaj S Professsor Linda Richards • • • • • • • • • • • • • • • • • • •
Associate Editor Editorial Board Editorial Board Advisory Faculty Editorial of1000, Board JAMA Psychiatry Genetics of Learning Journal(npj)Science Nature Partner Frontiers inNeural Circuits Frontiers inCellularNeuroscience PLOS Biology Journal ofComparative PhysiologyA The OpenNeuroscience Journal Neural Plasticity Hippocampus Channels BioMedCentral Physiology of Learning Journal(npj)Science Nature Partner Scientific Reports Neurosignals International JournalofBrain Science Frontiers inNeuroscience Associate Editor Faculty Member of1000, Editorial Board Editorial Board Advisory , Associate Editor , Editorial Board , Editorial Board , Editor-in-Chief S , Editorial Board , Editorial Board , Editorial Board
S rinivasan Queensland Brain Institute , Editorial Board tephen Williams , Associate Editor , Handling Editor Annual Report 2015 Annual Report , Editorial Board , ,
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Publications Recognition QBI ANNUAL REPORT 2015 Australia with a Lifetime Achievement award. award. Achievement aLifetime with Australia Perry Bartlett was honoured by Research Research by honoured was Bartlett Perry Photo courtesy of Research Australia. Research of courtesy Photo QBI Founding Director Professor
Recognition Our staff also serve on professional committees scientific organisations. scientific QBI researchers are among the best in the world, grants, and awards received in 2015. and represent the Institute in anumber of key as attested to by the quality of the fellowships, Queensland Brain Institute Annual Report 2015 Annual Report G O C E R NITION
Recognition Recognition QBI ANNUAL REPORT 2015 Fellowships National fications with respect to drug treatment. drug to respect with fications develop novel data analysis methods to methods analysis data noveldevelop genetic risk factors for psychiatric disorders, diseasesusceptibility determine diseaseauto-immune diabetes, disease, disorders, ultimately leading to prevention strategies, improved diagnosis and more and improveddiagnosisstrategies, 2015, in Commencing and motor neuron disease. and and will assess the value of using genomic and psychiatric disorders is a consequence across diagnostic boundaries, thereby boundaries, diagnostic across methods genomics in herexpertise apply In particular, he will focus on brain-related complex complex traits, which have been implicated course of his Senior Principal Research Principal Senior his of course Individual risk for conditions such as heart of the interplay between non-genetic and non-genetic between interplay the of environmental risk factors, which together of the accumulation of multiple genetic and our knowledge of genetic heterogeneity genetic of knowledge our She will also deliver a better understanding Wray predict disease risk and improve diagnosis. Fellowship, predictors intheseconditions. paving the way to explore genetic classi genetic explore to way the paving Research Fellow. This will allow her to her allow will Fellow.This Research in psychiatric disorders, cognitive ageing cognitive disorders, psychiatric in to and mutations gene causative identify Research Fellowships targeted treatments. to drive discovery in the area of psychiatric hasbeenpromoted to Principal Professor Peter Visscher will H ealth and Medical Research C Her goal isto increase ro e or ao . During the the During - Pankaj Sah Professor disorders, including post-traumatic stress. circuits leads to a range of anxiety-related these in Dysfunction amygdala. the as circuits within a region of the brain known increased our understanding of the neural Principal Research Fellowship, has greatly a of recipient Professor the Pankaj Sah , ouncil
developing targeted therapeutics. of goal the with humans, fromrecordings with Brisbane neurologists he will also make collaborationretrieved.In and formed are the amygdala and how emotional memories investigate how information is encoded in will Sah ProfessorFellowship, his During The fovea, the central part of the retina, is essential for for essential is retina, the of part central the fovea, The The aim of Amyotrophic lateral sclerosis (ALS) is a progressive and ALS ALS and the current approved treatment only prolongs Career Development Fellowships diagnosis, treatment andcure forthedisease. expertise bioinformatics and computational genetic, degeneration (AMD). survival survival by three months, with most patients dying within seven Australians over the age of 50 suffers from some strategies, such as the use of oculomotor training and and trainingoculomotor of use the as such strategies, and to determine their biological function. This knowl function. This biological their determine to and and breathing. At present there is no diagnostic test for vision of AMD patients and to investigate the neural the investigate to and patients AMD of vision adaptive displays. a major role in the development of disease. The goal of plays epigenetics increasingthat evidencethereis and for DNA methylation and gene expression levels, and levels, expression gene and methylation DNA for form of foveal blindness due to age-related macular age-related to due blindness foveal of form correlates of visual perception in peripheral vision. Ulti vision. peripheral in perception visual of correlates everyday functions that require high acuity, such as read edge will then be used in the search for an effective an for search the in used be then will edge on gene expression. This will elucidate the functional the elucidate will expression.This gene on elucidate the genetic control of DNA methylation, in order neurons that control muscle activity, such as walking activity,as muscle such control that neurons recognise objects in situations that involve visual clutter. provide valuable knowledge that can then be used to used be then can that knowledge valuable provide peripheral vision is low-resolution and it is difficult to difficult is it and low-resolution is vision peripheral DNA DNA methylation is an epigenetic mechanism that cells Fellowship, use to control experience-dependent gene expression, gene experience-dependent control to use mately, this work has the potential to inform rehabilitation mechanisms driving many of the genetic associations associations genetic the of many driving mechanisms in order to discover novel genes and epigenetic marksers, ing or facial recognition. However, approximately one in intact peripheral retina to process visual information, visual process to retina peripheral intact target them forfuture therapeutic interventions. Early Career Fellowships to dissect the genetic and epigenetic aetiologies of ALS, three years. During the course of his Career Development terminal neurological disease which destroys the motor to develop novel interventions that enhance the peripheral to define the molecular processes underlying its effect its underlying processes molecular the define to to understand how this affects disease susceptibility, and Dr AllanMcRae’s to DevelopmentCareerFellowshipis Dr WillHarrison’s Early Career Fellowship is Dr BebenBenyamin will apply his statistical, Although patients canuse their - - - Fellowships of BiomedicalSciencesandQBI. holds a joint appointment between the School ment of learning and memory deficits. She now reverse the processes underlying the develop therapeutic intervention to ameliorate or even as well as revealing potential cellular targets for that underpin optimal cognitive performance, new insights into the fundamental mechanisms Vukovic’sDr provideincreases. will research problem as the median age of the population increasing an be will which ageing, normal of result a as occur also can performance tivity and social isolation. Declines in cognitive poor educational outcomes, reduced produc to lead can memory and learning in deficits Understanding these processes is critical, as effects. their exert neurons adult-born these Dr JanaVukovic’show determine to is goal out life (i.e. adult hippocampal neurogenesis). regulated production of new neurons through- learning and memory is the hippocampus, by its for critical is that structure brain major The Discovery Early Career Researcher Award Australian Research C JanaDr Vukovic ouncil - - pioneering work has helped to establish to helped has work pioneering largest fibre tract in the human brain. Her the callosum, corpus the of formation opmental mechanismsthatregulate the Richards’ discoveries regarding the devel Professoracknowledges honour tigious pres highly This Science. of Academy Australian the of Fellow a elected been roscience, In recognition of her contribution to neu F ellow of the Australian Academy of Professor Richards Linda has - - -
understanding ofneural circuits. information that has implications for our final stages of brain wiring development, thefor critical arehemispheres two the to inputs balanced that discovered also role of glial cells in this process. She has and animal models, and in theparticular humans in forms callosum corpus the the fundamental principles underlying how Photo: MarkGraham. S cience Linda Richards Linda Professor Professor
sion with 88 percentsion with88 accuracy. depres pregnancy couldpredict postpartum of trimester third the from samples blood in profiles expression gene that demonstrating is designed to confirm results of a pilot study markers for depression.postpartum The study of 300 samples to identify early predictive bio- US to perform genome-wide genetic profiling tion between researchers in Australia and the Dr Divya to Mehtaplans acollabora establish YoungNARSAD Investigator Grant Research Brain & Behavior Mehta Divya Dr F oundation Queensland Brain Institute Fellowships
Annual Report 2015 Annual Report G O C E R NITION - -
Recognition Recognition QBI ANNUAL REPORT 2015 Fellowships neuronal deathin thesemice. the motor symptoms that are associated with improveto able been has work her used, is macologically enhancing the way that energy energy.phar use By cells and body whole the way the in changes alongside occurs she has shown that the death of nerve cells strategies for MND. In mouse models of MND, Ngo’streatment pioneeringDr is research who are allstrivingforaworldfree ofMND. a team of dedicated clinicians and scientists with this research in 2015, working alongside continued has Fellow,Ngo Sullivan Dr Scott the As progresses. (MND) disease neuron cells use energy can affect how quickly motor how changes in the way the body and nerve research has focussed on trying to understand years, four last the Over S cott S ullivan Research F r uan o uan r ellow -
that MND patients are not using energy effi number of critical observations that suggest through disease. Together they have made a body energy use also occuras they progress her team have shown that changes in whole Working alongside MND patients, Dr Ngo and of MND patients—from dying. of MNDpatients—from derived from induced pluripotent stem cells these compounds can also protect neurons— in mouse models of MND, and to show that neuronssaving of goal the with pathways FDA-approved compounds that target energy Dr Ngo’s ongoing research aims to repurpose the problem inenergy inpatients. use jects that are trying to pinpoint the cause of have led to the of birth a number of new pro MND.with findings cope These to able are ciently, and this may in turn affect how they r uan o r - - Ross Maclean causes ofsporadiccauses MND. the of understanding better toa lead will tise samples and clinical data biological of analysis and collection the for infrastructureintegrated an build to together collaborators. international working areThey nine MND centres across Australia as well as (SALSA-SGC) involves sixteen researchers from ALS Australian Consortium Genomics Systems which account for 10% of cases. The Sporadic ia’s largest study into sporadic cases of MND, ProfessorWrayAustralco-ordinating also is inChinaandHolland. cohorts largefrom data collecting patients, MND of genomes the sequencing involves work This , Visscher who are world leaders in genomics. by ation sequencing to find novel MND genes, led collaborative project that is using next-gener multifaceted large a of part forms lowship by theRossMacleanFelWork supported in thisprocess. involved be to known are genes MND known the of quarter one around date to death; cell tioning RNA processing leads to motor neuron Work at QBI aims to understand how misfunc neuron disease(MND). motor of causes genetic the uncovering on ship, With the of support the Ross Maclean Fellow ro e or ao ra and Professor Peter Dr MarieMangelsdorf’s focussed work F ellowship . This pooled exper ------Australian Health EthicsCommittee. the and Committee Research NHMRC the of member a and Research Health Mental for Centre Queensland the of DirectorExecutive made a major contribution to the discipline as min D deficiency andpaternal age. He has also for schizophrenia such as developmental vita factors risk non-genetic identify to robiology neu experimental with epidemiology linked has program that researchinnovative his for honoured was he Research, Health Mental ents of an NHMRC John Cade Fellowship for recipi two only of One McGrath.Professor Sciences. Medical and Health of Academy Australianformed newly the of Fellow a as In 2015Professor JohnMcGrath was elected F from awiderange ofdisciplines”. commentators social and thinkers, scholars, to voice a give to and sciences, and arts the in advances “promoteto aims Sciences and Arts of Academy Queensland The learning. of science the into research of leadership toicant contributions neuroscience and his signif his for 2015 in Sciences and Arts of Academy Queensland the of Fellow a as ted QBI Director Professor Pankaj Sah was admit F Academy of S and Academy of Arts Medical ellow of the Australian ellow of the Queensland ciences ciences S ciences H ealth and ealth and
- - - - - Awards Perry Bartlett Perry Professor covery of neural stem cells in the adult brain, honoured for his pioneering work in the dis and/or human health. Professor was Bartlett significant contribution to biomedical science a for Australianresearcheran to biennially the 2015 CSL Florey Medal, which is awarded of recipient the is Professor Bartlett Perry CSL F lorey Medal
- and his career-long leadership inthe disci Photograph: LornaSim. mental healthdisordersmental depression as such neurological diseases such as dementia, and neural stem cell populations inameliorating of potential the harness to efforts current . pline His seminal studies underpin many underpin studies seminal His - . Australian Academy Achievement Award American Publishers Awards for Professional Australian neuroscience, and has made a sig Associate Professor Jian Yang Research Australia Lifetime PRO diseases, particularly mental disorders. mental diseases, particularly success of his co-authored book and biotechnologicaladvances. and ScholarlyExcellence isto recognise pub contributions contributions to solving the “missing heritability” In In another accolade acknowledging his career- which won the prize for best textbook in the in textbook best for prize the won which cation of novel statistical genetics methods genetics statistical novel of cation of landmarkworks intheirfield”. edged in the 2015 PROSE Awards for the for Awards PROSE 2015 the in edged of the Queensland Brain Institute. His individ His Brain Institute. Queensland the of of pathways that play a major role in complex in role major a play that pathways paradox through the development and appli and development the paradoxthrough research capacitythrough theestablishment nificant contribution tothe growth of national pioneering works of research and for contrib uting to the conception, production and design ual research excellence is also exemplary, as for advocate dedicated a been has Bartlett is to identify genes, functional elements, or elements, functional genes, identify to is is his advocacy for the critical importance of importance critical the for advocacy his is trait variation. The ultimate goal of this work work this of goal ultimate The variation. trait the 2015 Ruth Stephens Gani Medal for his for Medal Gani Stephens Ruth 2015 the Ruth StephensGaniMedal that have allowed him to quantify the contri the quantify to him allowed have that tralia Lifetime Achievement Award. Professor health and medical research, bution of common genetic polymorphisms to basic scientific discoveries in driving clinical driving in discoveries scientific basic biological and life sciences. The goal of these Professor Marshall Justin alsoBartlett received the 2015 Research Aus lishers and authors for “their commitment to long commitment to supporting and promoting promoting and to commitment long supporting S cience cience S E Award has been acknowl Professor Perry Visual Ecology was awarded
------, Young ScientistAward Australian As As the recipient of the 2015 Federation of Asian 2015 Australian Society of Medical Research F Queensland HealthandMedical and Molecular Biologists and Oceanian Biochemists system function, given that dynamic changes system. Discovering how these receptors are and storage learningandmemory. during abad, India, and to take part in its Young its in part take to and India, abad, and Oceanian Biochemists and Molecular work at the 14th FAOBMB Congress in Hyder critical processes such as information coding focusses on AMPA receptors, which mediate Queensland Health and Medical Research Medical and Health Queensland Scientist Program. Sciences and QBI, was the recipient of the of recipient the was QBI, and Sciences Senior Researcher Award. of Medical Research regulated is critical for understanding nervous Biologists (FAOBMB) Biologists Award,Young Scientist mission in the mammalian central nervouscentral mammalian the in mission ment between the School of Biomedical of School the between ment in synapticstrength are thoughtto underlie Research SeniorResearcher Award the majority of fast excitatory synaptic transsynaptic excitatory fast of majority the was able to present his present to able Dr Victorwas Anggono , who holds a joint appoint joint a holds who o, uan r ederation of Asian S ociety ociety Queensland Brain Institute DrAnggono’s research Annual Report 2015 Annual Report
G O C E R Awards NITION - - -
Recognition Recognition Grants QBI ANNUAL REPORT 2015 Australian Alzheimer’s Australia - Ubiquitinomic profiling of profiling Ubiquitinomic Anggono,- Victor Research F fellowships awarded by The University of University The by awarded fellowships Queensland have also been included. been also have Queensland We are grateful for the following national and Reutens, David; Cooper, Matthew; Smith, Maree; included in the amounts shown. Grants andGrants shown. amounts the in included not are increments yearly and GST 2015; in starting fellowships and grants international Research Grants researchers are denotedin bold. oundation grants Thurecht, Kristofer; Venkatachalam, Taracad; 12/02/2015–31/01/2016, $50000. 12/02/2015–31/01/2016, Yasvir; Advanced Imaging) 5/7/2015–4/7/2022, 5/7/2015–4/7/2022, Imaging) Advanced Allavena, Rachel; Straw,Rachel; Allavena,Tesiram,Rodney; synaptic proteins in Alzheimer's disease,Alzheimer's in proteins synaptic $2500000. Boyd, Andrew; Boyd, ular Imaging Agents in Cancer,in (awarded Agents Imaging ular Bhalla, Rajiv; Markus; Barth, Palmieri, Chiara; to and administered by UQ’s Centre for CentreUQ’s by administered and to Osborne, Geoffrey - ACRF Facility for Molec Perry ; Russell, Pamela; Walker, David;Walker, Pamela; Russell, ; ; Francois, Mathias; Francois, Bunt, Jens; F C oundation Richards, Linda; ancer Research ancer Research D ementia ementia Bartlett, Bartlett, QBI - Australian Australian Research C CRC Program 1Project grants CRC forLivingwithAutism Spectrum C C - How does neurogenesis in neurogenesis does How - Vukovic, Jana Cheney,Karen; Gratten, Jake; - The plasticity of neuralof plasticity The - Goodhill, Geoffrey Disorders (Autism CRCLimited) Discovery Project Grants Discovery CareerEarly Researcher Awards Powell, Joseph - The role of zinc in synaptic in zinc of Lynch,role The - Joseph Meunier, Frederic entres (CRC ooperative Research - How different is different: highly contrast highly different: is different How - 7/06/2018, $1743245. 7/06/2018, 1/01/2015–31/12/2017, $372000. 1/01/2015–31/12/2017, 1/01/2015–31/12/2018, $434500. 1/01/2015–31/12/2018, 1/01/2015–31/12/2017, $369900. 1/01/2015–31/12/2017, & & memory? (awarded to QBI but transferred standing how genetic variation regulates the and and validation of systems genomics-based and administered by UQ's School of Biolog- administered by UQ’s Institute for Molec UQ’sfor by Institute administered codes, 1/01/2015–31/12/2017, $439000. codes, 1/01/2015–31/12/2017, Institute, transferred to QBI in 2015, now 2015, in transferredQBI toInstitute, of vesicular docking in neurosecretory cells, $497800. $364525. predictors for autism (Stage 1), 7/12/2015– ular Bioscience), 1/01/2013–31/12/2015, Bioscience), ular ical Sciences), 17/02/2015–16/02/2018, Sciences), ical (awardedto patterns animal in colours ing transcriptome (awarded to UQ's Diamantina to UQ's School of Biomedical Sciences), Biomedical of School UQ'sto learning influence hippocampus adult the transmission in the central nervous system, ; Endler,Marshall, Justin; John - Novel approaches for under Wray,Development - Naomi G - Unravelling the mechanism overnment ) Program ouncil - - - Travel Awards Travel Grants Ian Potter BioPharmaceutical Australia H Brain Research Brain and Behavior S C - Ian Potter FoundationPotter TravelIan - Zhao, Qiongyi Innovator Award Research Grants - The role of neural activity in in activity neural of role The - Suárez, Rodrigo Research Gifts YoungNARSAD Investigator Awards Biopharmaceutical Development Fund - Analysis of the role of role the of Analysis - Piper, Michael Bunt, Jens; biomarkerspredictive Early - Mehta, Divya Perry - Bartlett, A novel ephrinA4-Fc fusion pro cholarship and ontributing to Australian ydrocephalus Association 1/12/2015–30/11/2016, $30484. 1/12/2015–30/11/2016, for 2015. $41047 14/01/2017, 21/2/2015–26/02/2015, $2000. 21/2/2015–26/02/2015, Grant to attend Keystone Symposium meet disease, disease, 1/01/2015–31/12/2016, $250000. vating the NFI pathway be used to treat to used be pathway NFI the vating alus, (awarded to and administered by administered and to (awarded alus, 31/12/2015, $39842. 31/12/2015, for postpartum depression, 15/01/2015– depression, postpartum for early early postnatal wiring of interhemispheric cor UQ's School of Biomedical Sciences), Biomedical of School UQ's primary primary human GBM tumours? 1/01/2015– NFIX in the development of hydroceph of development the in NFIX ing ing on Neuroepigenetics, Santa Fe, Mexico, tical circuits, 18/05/2015–20/05/2015, $2500. tein tein for the treatment of neurodegenerative F oundation Richards, Linda (re-)acti -Can F F oundation oundation S cience cience
- - - - - The MND Australia Inc. Insurance International Brain Research Organisation Research Institute of Research Instituteof Motor Neurone Motor Accident and Metro North and Metro North and Ice Bucket ChallengeGrant International TravelGrants Suárez, Rodrigo - Development and evolution Wray,Blair,Ian; Naomi; Funding Program Nasrallah, Fatma -Motor Accident Insur ResearchSullivan Scott The - Ngo, Shyuan 1/01/2015–31/12/2015, $3000. 1/01/2015–31/12/2015, Vucic, Steve; Williams, Kelly; Consortium (SALSA-SGC), 6/10/2015– (SALSA-SGC), Consortium 31/12/2017, $194999. 31/12/2017, 31/10/2020, $1500000. 31/10/2020, Research QBISenior Commission ance 30/11/2018, $1050000. 30/11/2018, of interhemispheric cortical connections, cortical interhemispheric of Sporadic ALS Australian Systems Genomics Fellowship, Fellow appointed 31/01/2015– Fellowship, Fellow appointed 31/10/2015– Dominic; Schultz, David; Schultz, Dominic; Nicholson, Garth; Pamphlett, Roger; Rowe, Nigel; Mathers, Susan; McCombe, Pamela; Henderson, Kiernan, Robert; Matthew; Laing, H ealth andMEF C S ommission ervice ervice D
Benyamin, Beben; H isease isease Visscher, Peter; ospital ospital
oundation oundation . Zhao, Qiongyi
- - Grants National Career Development Fellowships Early Career Fellowships – Understanding the genetic the Understanding Power, – Robert Harrison, William McRae, Allan - Genetics of DNA methylation and Benyamin, Beben -An integrated genomic and standing peripheral vision in patients with patients in vision peripheral standing architecture of psychiatric disorders in disorders psychiatric of architecture 31/12/2018, $411768. 31/12/2018, 31/12/2018, $411768. 31/12/2018, central vision loss, 1/06/2015–31/05/2019, of motor neuron disease, 1/01/2015– disease, neuron motor of epigenomic approach to dissecttheaetiology $289436. patients and populations (Declined). andpopulations patients its role in disease susceptibility, 1/01/2015– H ealth and Medical Research C - Novel approaches to under- Fath, Thomas; Fath, Evans, David; Relton, Caroline; Goodhill, Geoffrey - Computational analysis of Evans, David; Venkatesh, Bala; Project Grants ; Windischeberger,Chris Cunnington, Ross; Benyamin, Beben; Burne, Thomas; The ADRENAL-GEPS Study (awarded to and 1/01/2015–31/12/2017, $834270. 1/01/2015–31/12/2017, 1/01/2015–31/12/2017, $570364. 1/01/2015–31/12/2017, filing in critically ill patients with septic shock: genome-wide DNA methylation data from data methylation DNA genome-wide skas, Andrius - Targeting the synaptic actin administered by UQ's Diamantina Institute), vitamin D deficiency increase vulnerability increase deficiency D vitamin 1/01/2015– cardiovasculardisorders, and 31/12/2017, $276398. 31/12/2017, $358957. 31/12/2017, cytoskeleton in Alzheimer's Disease (awarded function? 1/01/2015–31/12/2017, $319776. Smith, George - Novel ways of utilizing of ways Novel - George Smith, on axon guidance, 1/01/2015–31/12/2017, neuropsychiatricon factors risk of effects epidemiological methods to infer the causal South Wales), 1/01/2015–31/12/2018, Wales), South $335492. $808872. UQ's Diamantina Institute), 1/01/2015– Institute), Diamantina UQ's peripheral bloodsamples ingenetic epide Peter; Power, John; Karl, Tim; Masedun Tim; Karl, John; Power,Peter; McLachlan, McLachlan, Geoffrey - Gene expression pro Myburgh, John; Finfer, Simon; Cohen, Jeremy; miology (awarded to and administered by administered and to (awarded miology in Brh Mru - High-resolution - Markus Barth, tian; the influence of growth cone shape dynamics to and administered by the University of New to social stress resulting inaltered brain brain imaging of basal ganglia function, ganglia basal of imaging brain ouncil ; Gunning, Anggono, Victor; McGrath John -Does adult - Novel - Brion, Marie-Jo Powell, Joseph; Powell, Joseph ; - - - - ; Sale, Martin Lynch, Joe; Anthony; Hannan, Laird, Angela; Nicholson, Garth; Becker, Thomas; Martin, Nicholas; Martin, Lee, SangHong ; Powell, Joseph-Determining shared genetic - Transgenerational impacts of paternal of impacts Transgenerational- - Mimicking slow wave sleep to enhance to sleep wave slow Mimicking - of etiology the in Tacklingheterogeneity - - Advanced whole-genome approaches for approaches whole-genome Advanced - 1/01/2015–31/12/2017, $343952. 1/01/2015–31/12/2017, 1/01/2014–31/12/2016, $428834. 1/01/2014–31/12/2016, 1/03/2015–28/02/2018, $415106. 1/03/2015–28/02/2018, $2445015. 1/01/2015–31/12/2019, (awarded to and administered by the Univer stress on offspring mental health: Epigenetic sity of Melbourne), 1/01/2015–31/12/2017, science), 1/01/2015–31/12/2017, $256398. 31/12/2017, $498009. 31/12/2017, Sydney),of University the by administered and administered by The Council of the of Council The by administered and ferred to University of New England in 2015), cial synapses to investigate the functional the investigate to synapses cial control of RNA transcription across 45 across transcription RNA of control causative variant detection and individual and detection variant causative Queensland Institute of Medical Research), Medical of Institute Queensland $554937. pathology underlying epilepsy,underlying 1/01/2015– pathology human in traits complex of prediction risk populations (awarded to QBI but trans but QBI to (awarded populations drug Investigating - Giacomotto, Jean mechanisms and therapeutic interventions lsiiy n h edry ua brain, human elderly the in plasticity Julio; Licinio, using transgenic zebrafish (awarded to and major depressive disorder (awarded to (awarded disorder depressive major transferred to UQ's Institute for Molecular Bio treatments for a Machado Joseph disease Joseph Machado a for treatments human tissue types (awarded to QBI but QBI to (awarded types tissue human - Using artifi Using Keramidas,- Angelo Mattingley, Jason; Giulio, Tononi ; Medland, Sarah Medland, ; Byrne, Enda Gerhard, Moser; Bredy,TerrancePang, Tim; ; Hickie, Ian;Wray, Hickie, ; Naomi Yang, Jian - - - -
Visscher, Peter Wen, Wei (from Jan 2015); Sachev,2015); Jan Wen,Wei(from Perminder Wray,Fellowship: Research Principal - Naomi - Principal Research Fellowship:Research Principal - Sah, Pankaj Wray, Naomi; Wright, Margaret Wray,; Naomi Blair, Ian - Gene discovery in motor Williams, Stephen Research Fellowships - Multivariate whole genome estimation genome whole Multivariate - Twins Study (OATS) of healthy brain ageing 1/01/2015–31/12/2019, $739980. 1/01/2015–31/12/2019, 1/01/2015–31/12/2017, $918784. 1/01/2015–31/12/2017, 1/01/2015–31/12/2018, $861300. 1/01/2015–31/12/2018, $1045325. 1/1/2013–31/12/2015, Ames, David; Baune, Bernhard; Lee, Ter Lee, Bernhard; Baune, David; Ames, during adolescence: a longitudinal imag genomics, genomics, 1/01/2015–31/12/2019, $886915. disorders, 1/01/2015–31/12/2019, $739980. (awarded to and administered by the Uni the by administered and to (awarded (2013-2014); (2013-2014); applied to psychiatric disorders, 1/01/2015– data genomics of analysis prediction and versity of New South Wales from 2013), from Wales South New of versity 31/12/2019, $610529. 31/12/2019, and age-related neurocognitive disordersneurocognitive age-related and 31/12/2020, $1634767. 31/12/2020, cil of the Queensland Institute of Medical of Institute Queensland the of cil Queensland Institute of Medical Research Medical of Institute Queensland essa; Crawford, John - The Older Australian Using genomicsto understandpsychiatric neuron disease through systems genomics, Katie; Katie; Thompson, Paul - Neurodevelopment Fellowship: Neurogenetics and statistical and Neurogenetics Fellowship: Neural circuits that underpin fear and anxiety, Research, now at QBI from 28/10/2015); from QBI at now Research, ing study (awarded to The Council of the of Council The to (awarded study ing tion tion processing in visual circuit computations, but but transferred to QBI in 2015), 1/01/2015– Lee, Sang Hong ; de Zubicaray, Greig; McMahon, -Senior Principal Research Wright, Margaret - Role of dendritic informa dendritic of Role - Queensland Brain Institute Annual Report 2015 Annual Report ; Gratten, Jacob G O C E R (The Coun (The Grants NITION - - - - -
Recognition Recognition Grants QBI ANNUAL REPORT 2015 Awards (R21) National InstitutesofH Cooperative Agreements (U54) Visscher,of Weir,University (Bruce lead, Peter US Visscher, Peter (Isaac Kohane, US lead, Harvard Med Van Swinderen, Bruno (Paul Shaw, US Lead, Wash Visscher,UniverKeller,- Lead, (Matthew PeterUS Wright, Margaret (Paul Thompson, US lead, Univer Wray, Naomi Research Program Project Grants (P01) Exploratory/Developmental Research Grant Research Program Project Grants (R01) Eyles,; Darryl Eyles, Darryl (Gayle Wynham, US lead, Sequoia Foun Richards, Linda (Elliot Sherr, US Lead, University of 2015 funding: $72339. 2015 GxE GxE detection by using multi-locus genome-wide disorders, nofundingrequested for2015. dation, dation, 2015-2018) - Role of pre-natal Vitamin D (Patrick Sullivan, US Lead, University of North North of University Lead, US Sullivan, (Patrick sity sity of Southern California, 2014–2018) - ENIGMA sity of California, 2013–2017) - Estimating the Estimating - 2013–2017) California, of sity Center for Worldwide Medicine, Imaging & Genom as a window into common neurodevelopmental California, 2007–2020) - ACC: callosal agenesis alleles, $153322 for 2015. alleles, $153322 for 2015. and disease,$132024 health in neurons promoting sleep of analysis and gene interactions inAutism Spectrum Dis Carolina Chapel Hill, 2006–2019) - 1/2 A Large- A 1/2 - 2006–2019) Hill, Chapel Carolina Washington, 2012–2017) - Statistical and Quan risk of specificities population and frequencies orders; leveraging an existing case-control study, $76126 for 2015. $76126 Scale Schizophrenia Association Study in Sweden, $132038 for 2015. $132038 predictors, for 2015. $70668 disorders, spectrum autism of risk and levels D DrexelUniversity, lifeEarly - 2014-2016) vitamin ics, $63025 for 2015. ics, $63025 ington University, 2011–2016) - Functional - 2011–2016) University, ington ical School, 2015-2017) - Increasing the power of titativefor 2015. Genetics, $202006 (Brian Lee, US lead, US Lee, (Brian McGrath, John Visscher, Peter ; Powell, Joseph ealth (US A) ------
The Wesley-S Research InstituteLimited Research Rebecca L.C Research Biological Psychiatry S S - The Stafford Fox Medi Fox Stafford The - Zuryn, Steven Walker, David; International TravelAwards Suárez, Rodrigo; Research Grants - International TravelInternational - Mehta, DivyaAward, of translation Reverse - Burne, Thomas tafford ociety of –1/09/2019, $2500000. –1/09/2019, 1/01/2015–31/12/2015, $2000. 1/01/2015–31/12/2015, $22000. 1/03/2015–31/12/2015, administered by the Wesley Research 31/12/2015, $138000. 31/12/2015, nttt) 2/03/2015–28/02/2016, Institute), wiring of interhemispheric cortical circuits, of models animal for tasks cognitive cal Research Foundation for a Senior a for Foundation Research cal for glioblastoma patients (awarded to and for novel prognostic indicators of survival $18834. role of neural activity in early postnatal early in activity neural of role neuropsychiatric disorders, 24/01/2015– Dementia, Dementia, Fellow appointed 1/09/2014 Research Fellowship in Stroke-Inducedin Fellowship Research F Osborne, GeoffreyOsborne, -Searching F F ox Medical
oundation oundation - TheRichards, Linda ooper Medical ooper Medical t. Andrew's - The University ofQueensland Advancing Women Researchers Grants - UQ Advancing WomenAdvancing UQ Vinkhuyzen,- Anna UQ-NHMRC Equipment Grants Boyd, Roslyn; Liley, Helen; Hurrion, Elizabeth; Major Equipment Early Career Researcher Grants Cooper, Helen; and Infrastructure Grants Perry Bartlett biological To- the Mehta, Divyainvestigate 18/05/2015–5/08/2016, $1867. 18/05/2015–5/08/2016, 1/1/15–31/12/2015, $210000. 1/1/15–31/12/2015, Jonathon - Optimising Neonatal Neuro Neonatal Optimising - Jonathon speed 3D imaging of tissue and live organ oges f sciti Genetics, Psychiatric of Congress Childrens Hospital and the Mater Mothers Childrens Mothers theMater and Hospital eficial effects of pregnancy for Multiple for pregnancy of effects eficial Sclerosis, 1/01/2015–22/07/2016, $40000. $80196. othy; ning disc confocal microscope for high for microscope confocal disc ning Luke; Gray, Peter; Justo, Robert; Corness, Luke; Gray,Robert; Justo, Peter; Paul; Colditz, Paul; puterised stereotaxic rapid and puterised stages Hospital at the University of Queensland, of University the at Hospital MRI compatibleincubator atLadyCilento an for consortium research plasticity: Rose, Stephen; Wallace, Geoffrey; Dawson, ResearchersGrants WorldRound - 2015 mechanism underlying the long-term ben long-term the underlying mechanism immunolabelling, 1/01/2015–31/12/2015, immunolabelling, 1/01/2015–31/12/2015, isms, 1/01/2015–31/12/2015, $236195. 1/01/2015–31/12/2015, isms, tissue tissue processor for enhanced fixation and Michael Richards,; Linda Marshall, Justin; Massimo Piper, Michael; Hilliard, Massimo; ; Coulson, Elizabeth -Spectral appliedresearch spin ; Götz, JürgenGötz, ; Sah, Pankaj Goodhill, Geoffrey ; Blackmore, Daniel -Com Richards,; Linda Jardine, Cooper, Helen; Meunier, Frederic ; Richards,; Linda ; Götz, Jürgen ; ; Bredy, Tim Hilliard, Hilliard, Piper, ------Travel Awards forInternational Vice-Chancellor's Research Collaborative Research Porter, Megan (visiting academic), (visiting Porter,Megan Focused Fellowships Postdoctoral Research Fellowships Hilliard, Massimo - Axonal fusion: new strat Padmanabhan, Pranesh -Mathematical Durisic, Nela - The effects of human epilepsy 1/01/2015–31/12/2017, $324298. 1/01/2015–31/12/2017, Justin, 1/01/2015–31/12/2015, reimburse studied by localization-based Super-resolu egies to repair injured axons (Relinquished $346409. ment oftravelment expenses. modelling of neural wiring development, wiring neural of modelling onsynapticGABA-Amutations receptors to take up an NHMRC Senior Research Fel- tion microscopy, 1/01/2015–31/12/2017, lowship in2016). Marshall, - - - QBI scientists at the Clem Jones Centre for for Centre Jones Clem the at scientists QBI 3D-printed imitation bone is being used by by used being is bone imitation 3D-printed Ageing Dementia Research to simulate how sound waves travel through bone. through travel waves sound how
As well as securing grant funding to support support to funding grant securing as well As Götz, from the Clem Jones Centre for Ageing for Centre Jones Clem the from Götz, develop and protect its intellectual property. QBI some of these activities through the competitive a on working been has QBI Boyd, Andrew sor science research in the Asia-Pacific region. QBI and initialclinicaldevelopment. a company who would then fund the preclinical identify to processes and people the has also Institute to position itself as a leader in neuro in leader a as itself position to Institute In the second project, QBI’sproject, JürgenProfessorsecond the In In particular QBI has made significant progress QBI has focused its attention on growing its growing on attention its focused has QBI of internationally recognised research staff and er's disease. The technology has been shown been has technology er'sThe disease. of The University ofQueensland. arm commercialisation main the UniQuest, of of Professor and, subsequently, Perry Bartlett new commercial with opportunities the support Dementia Research, has continued to work on potential licensing deal is being discussed with Biopharmaceuticals Australia (BPA) scheme, a industry engagement and will continue to continue will and engagement industry in the medical device field. For the first, under first, the For field. device medical the in jects in 2015, one in the therapeutic field and one technology as a potential treatment for Alzheim the recent discovery of non-invasive ultrasound towards the commercialisation of two key pro towards aclinicaltrial. therapeutictargeting EphA4 thatis progressing Profes and Bartlett Professor of direction the translation ofits research under the direction has been able to recruit and maintain a team QBI HAD A HAD QBI ro e or an a a leading technologies, which has allowed the allowed has which technologies, leading successful yearsuccessful in progressing the the - - - - Science ofLearning discovery from the Meunier lab regardinglab free Meunier from discoverythe device prototype for testing in larger animals larger in testing for prototypedevice accomplishment fortheInstitute. accomplishment Centre (CRC) for Living with Autism Spectrum funded by the Australian Research Council. QBI cation might be for important our understanding fatty acids generated during neuronal communi Finally,ainjuries. cord spinal and nerve with fusion was important and could have significant QBI has also made several invention disclosures only those suffering with aging dementia but dementia aging with suffering those only not affect potentially could memory—and of ease. A discovery from the Hilliard lab in axonal ers will participate in the Cooperative Research of number a with work to continued also QBI Sah as Editor-in-Chief, which is a prestigious a is which Editor-in-Chief, as Sah research. QBI has also partnered with Nature with partnered also has QBI research. researchers continue to work with Euclideon, a note is a discovery from the Götz lab relating to Publishing Group to establish the journal the establish to Group Publishing Brisbane-based 3D visualisation company,visualisation to 3D Brisbane-based Disorders and the Science of Learning Centre Learning of Science the and Disorders Defence Australia, and several QBI research QBI several and Australia,Defence icant implications as a potential therapeutic to implications in neurosurgery and for patients for and neurosurgery in implications industry partners in 2015, including Boeing including 2015, in partners industry tau-specific antibodies, whichmay havesignif translational strategies for these discoveries. Of this year, and will work with UniQuest to develop the widercommunity. team team is working towards developing a medical to be effective in mouse models as measured build build new 3D visualisation tools to brain support battle some of the causes of Alzheimer’sdis of causes the of some battle before humantrials. commencing potentially by improved memory function. Professor Götz’s with Professor PankajProfessor with npj Commercial development - - - - The product called Dicer is software developed Also in 2015, QBI had one of the first products at QBI for flow cytometry machines enabling machines cytometry flow for QBI at around research. andcommercial opportunities with discussions several held UniQuest and actions onUniQuest’s recently launchedeShop. and with the ongoing support of UniQuest. of support ongoing the with and to QBIresearchersance andsupport to assist Institute’s research teamsto pursuecommer forward to attending BIO2016 in San Francisco. (http://eshop. types cell infrequent for cifically from UQ available for direct sale via online trans commercialisation sectors. biotechnology,pharmaceutical, the in working provideswhich workshop, commercialisation this, support further UniQuest will be delivering cial opportunities arising from their research. To In 2016 QBI will work to provide more guid more provide to work will QBI 2016 In Queensland delegation at BIO2015 and looks and BIO2015 at delegation Queensland Science Life the of part as exhibited also QBI in BIO2015 exhibited at attended and QBI also expert expert advice and guidance from professionals early-career researchers about how they can use to QBI’s support educational postgraduate and UQ researchers with the toopportunity receive UniQuest will continue to work alongside the alongside work to continue will UniQuest research. One way this will also be achieved is pharmaceutical and biotechnology companies pharmaceutical and biotechnology companies Philadelphia. BIO is one of the largest interna largest the of one is BIO Philadelphia. uniquest.com.au/dicer/). uniquest.com.au/dicer/). investment, intellectual property and investment,research intellectual property transfertechnology and engagement industry in translating their research, through forums through research, their translating in those machines around the world to sort spe sort to world the around machines those tional conferences for biotechnology and QBI and biotechnology for conferences tional inUniQuest’sthrough QBIparticipation annual their of potential commercial the enhance to Queensland Brain Institute Annual Report 2015 Annual Report G O C E R NITION - - - - -
Recognition Recognition QBI ANNUAL REPORT 2015 euro en e e nar Through a weekly seminar program, QBI gives Joon-Yong An TH TH TH TH Glutamatergic circuits stress in susceptibility: series series challenges researchers in their thinking, about about the latest scientific developments. The and therapeutic perspectives disease: afocuson myeloid dendritic cells spectrum disorder cohort of geneticvariants inan Australian autism ers in the 2015 QBI Neuroscience Seminar Neuroscience QBI 2015 the in ers Series are listedbelowinalphabeticalorder. Stephanie Biergans neuroscientists an opportunity to learnmoreneuroscientists anopportunity promotes excellence through the exchange of ideas and leads to future collaborations. Speak watermark ofcocaineself-administration reprogramming: functional consequences methylationanditsrole DNA methylation:anepigenetic DNA Modulating tau isoforms by RNA Molecular mechanisms in honey bee memory formation in honey beememory G Dr MariaElenaAvale Dr Victor Anggono Dr Paola Bossù Bagot Dr Rosemary Danay Baker-Andresen S QUEEN S QUEEN S QUEEN S QUEEN IRCCS ICAH INS C ENETI E V UNI E V UNI E V UNI E V UNI TITUTE OF N S SCHOOL O ANTA LU ANTA D LAN D LAN D LAN D LAN G EN ERS ERS ERS ERS ITY O ITY O ITY ITY O ITY O ITY G INEERIN MOLEC BRAIN IN S BRAIN IN S BRAIN INS BRAIN INS C F IA IA F F F F MEDIC S QUEEN S QUEEN S QUEEN S QUEEN F ULAR BIOLOG D OUN (IN TITUTE, TITUTE, TITUTE, TITUTE, INE AT MOUNT S G
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PITAL, NS S S SA LO C AL AL W euro en e e nar The truth or the technique: imaging The truthorthetechnique:imaging The USBRAINinitiative A newlookat gating: selective integration A genome-wideassociationstudy TH TH Genes and synapses: dissecting the Genes and synapses:dissectingthe dynamics inprefrontal cortex signalsthroughof sensory network of schizophrenia inSouthernIndia during decision-making striatum duringactive decision-making Using collaboration to advance our understanding ofbrain structure: Results from consortium theENIGMA Detecting covert changes-of-mind changes-of-mind Detecting covert insights into Alzheimer's disease G S S S S S Professor ReadMontague Dr Sarah Medland Dr JessNithianantharajah Professor BillNewsome Professor BillNewsome Professor BillNewsome Professor Peter Nestor Professor Mowry Bryan QIMR BERGHOF S QUEEN RES NEUROIMA basis ofcognitionandmental diseases MENTAL F D DIS LOREY INS TAN TAN TAN TAN TAN EPT OF ERMAN E WELL E V UNI EASES EARCH F F F F F OR OR OR OR OR D LAN P H ERS C D D D D D C , MA HYSI EALTH INS ENTER V UNI V UNI G OME TRUS SCHOOL O SCHOOL O SCHOOL O TITUTE OF ING ITY O ITY BRAIN IN S G GDEBUR TITUTE, CS ER MEDIC , V UNI ERS ERS , T & F F H OR DEG NEURO S QUEEN V ITY, ITY, ITY, E V UNI IRG T F F F ERS SCIENC NEURO V MEDIC MEDIC MEDIC C , C C IRG TITUTE, G ENTRE INIA TECH AL RES ALIF ALIF ITY ITY ERMANY ERS INIA TECH D LAN C ORNIA, U ORNIA, U INE, INE, INE, U OLLEG ITY O ITY F EARCH
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The role of regulatory longnon-coding TH TH TH Associate Professor StephanPless Shape-shifting dynamin: multiple dynamin Shape-shifting dynamin:multipledynamin at theatomic level channel signaling withpsychostimulants conformations forendocytosis andmore Understanding face perception Understanding faceperception Using an expandedgeneticcodeto study with fastperiodicvisualstimulation Insect ocelli, eyes for every function: Insect ocelli,eyes for every function: results oftraditional andX-ray CT techniques RNAs inadaptive behaviorRNAs Mechanisms underlying plasticity of potassium Mechanisms underlyingplasticityofpotassium Molecular mechanismsregulating Evolution of animalcolourvision ion channel function and pharmacology ion channelfunction and pharmacology CHILD Dr BrunoRossion Dr KatherineRoche Professor PhilRobinson Professor WilliRibi Professor DanielOsorio Professor CharlesFStevens Paola Spadaro Professor Paul Slesinger S QUEEN ICAH INS C NEUROSCIEN PRINC NATIONAL INS PRIV V UNI V UNI V UNI E V UNI E E V UNI TITUTE OF S ATE V UNI N ERS ERS ERS ALK INS REN' IPALITY OF SCHOOL O D LAN ITY O ITY ITY O ITY O ITY ERS ERS S MEDIC ITY O ITY ITY O ITY TUTITE, RES BRAIN INS ERS F F C F SU TITUTES E RE LOU LIE OPENHAG F ITY O ITY EARCH F F SYD SSEX, UK MEDIC S AL RES S QUEEN V ERCH CHTENS AIN, BEL C O ALIF F NEY T TITUTE, F H IN P IN C INE AT MOUNT S H EARCH EN, EN, ORNIA, U E ENTER,HE BET EALTH D LAN TEIN TEIN
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SA SA TH TH Associate Professor Hirokazu Tanaka J GPCR dysfunctioninAlzheimer’s disease (or howto make a mammalianbrain) Seeing at the limits: vision and Seeing atthelimits:vision and Colour vision inmantisshrimps: visual navigation innocturnalinsects complex visual systemsintheworld AND Implication of phospholipase D1 generated Implication ofphospholipaseD1generated movements: aspatialdynamicsmodel understanding one of the most understanding one of themost neuronal development phosphatidic acidinneurosecretion and How the motor cortex represents body representsHow the motor body cortex circuits Deep-time epigenesisofneocortical Deep timeandmodernbrains S Professor NickStrausfeld FRS Professor EricWarrant Professor Gordon Wallace Dr NicolasVitale Hanne Thoen Amantha Thathiah Dr Dr RodrigoSuárez S QUEEN S QUEEN INS INS D D KAT CES NEUROSCIEN V UNI V UNI V UNI APAN ADV TRAS EPARTMENT OF EPARTMENT OF E V UNI E INTELLIG TITUTE OF C TITUTE, V UNI H TECHNOLO ERS ERS ERS OLIEKE V UNI BOURG D LAN D LAN ITY O ITY ITY O ITY ITY O ITY ERS ANCED ITY O ITY ENT POLYMER RE , BRAIN IN S BRAIN IN S F F F S S QUEEN LUN ARIZONA, USA ELLULAR AND G TRAS ERS SCIENC NEURO BIOLOG , V UNI Y, I Y, ERS INS F S QUEEN D SHIKAW, ITY O ITY , BOURG ITY, LEU S TITUTE OF ERS WED D LAN TITUTE, TITUTE, Y, Y, F WOLLONG ITY O ITY
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euro en e e nar The role of nucleosome remodeling in TH TH TH Associate Professor JianYang Cortical-hippocampal interactions interactions Cortical-hippocampal Considering obesityasachronic brain disease anaesthesia inDrosophila melanogaster shape analysisandimaginggenetics complex traits andcommondiseases disability disorders synaptic plasticity, memory, andintellectual A Oressia Zalucki Xianfeng Yang robustness: perfecting hindgut-to-motor neuron transdifferentiation using wholegenomesequencedata Epigenetic determination of biological Epigenetic determinationof biological Presynaptic mechanismsofgeneral Diffeomorphic metric mapping,brain Estimating geneticvariation forhuman in adaptive decision making C Dr Steven Zuryn Dr JaiYu Dr GilesYeo Professor Marcelo Wood S QUEEN S QUEEN S QUEEN INS MRC RES CES NEUROSCIEN U V UNI V UNI DDENBROOKE' ELLULAR BIOLO G CSF E V UNI E V UNI E V UNI TITUTE OF G EARCH INS ERS ERS S AND D LAN D LAN D LAN TITUTE OF ITY O ITY O ITY ERS ERS ERS LABORATORIES LER ITY O ITY O ITY O ITY BRAIN INS BRAIN IN S BRAIN IN S F C F C S HOS ENETICS C , AMBRIDGE METABOLI C ALIF ENTER S F F F Y (I METABOLIC AN AN S QUEEN S QUEEN S QUEEN G ORNIA, IR PITAL, Queensland Brain Institute F BM RANCI F D AN TITUTE, TITUTE, TITUTE, OR INTEG C , WELL ), D LAN D LAN D LAN C S MOLEC AMBRIDG O, U SCO, TRAS V Annual Report 2015 Annual Report SCIENC INE, U
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Recognition Recognition Conferences QBI ANNUAL REPORT 2015 “We attracted leaders working across the fields The Cortical Connections conference alsoconference Connections Cortical The 200 members of the community,the includingof members 200 C disorders, and researchers investigating the disorders ofbrain wiring. share data for people with corpus callosumcorpus with people for data share willgroup The Health. Mental and science Connections, presented by A Clear Direction around onein3,000people. for the Corpus Callosum and CerebralCon and Callosum Corpus the for called the International Research Consortium corpus callosum and brain wiring disorders,” from the USA, France and Brazil, and domes members comeInternational consortium developmentalas well as callosum, corpus focus on the function and development of the Organised by Professor Linda Richards, the Richards, Linda Professorby Organised Institute, and the Florey Institute of Neuro of Institute Florey the and Institute, conference brought together internationaltogether brought conference of brain development, the genetics of cortical order (ASD)—a satellite meeting to Cortical order (ASD)—a an or er o ere ral onne t t consortium looking to understand theconsortium func neuropsychological outcomes of people with people together we also had the opportunity these bringing “By said. RichardsProfessor nectivity (IRC5),” shesaid. Financial Planning, which was attended byattended was which Planning, Financial malformations, brain imaging of brain wiring malformations, which have an incidence of incidence an have which malformations, individuals andfamilies. to form a terrificnew international consortium tically from UQ, Murdoch Children’s Research health workers, physicians working with ASD tion and development of the corpus callosum development and tion callosum the corpus of hosted aWorkshop dis onautismspectrum QBI HOSTED CORTICAL resulted intheformation ofaninternational leaders in the field of brain wiring, with a with wiring, brain of field the in leaders March 19–20, a unique conference that ortical ortical C onnections Connections from - - - - - The two-day program had a number of keynote 9th Alzheimer’s +Parkinson’s D (University of Califromia Irvine), Professor Victor (Riken), Professor Christian Czech (Roche Czech Christian Professor (Riken), an ar n on ea e A po u and across the globe for the 9th Alzheimer’s nan (University of Sydney), Professor Kim Green Pharma Ltd, Basel), Professor Matthew Kier Matthew Professor Basel), Ltd, Pharma than 191researchers from throughout Australia lectures were given by Professor Takaomi Saido lectures, talks shorter and workshops. Keynote FROMAPRIL 23 – 24, QBI was host to more - isease The 10th A+PD Symposium will be held in May Jia Jianping (Hospital of Beijing Capital Medical Villemange Villemange (University of Melbourne), Professor Above: A poster session at the 9th A+PD symposium. 2016 at QBI. 2016 versity ofCaliforniaIrvine). and and Professor Lars Ittner (The University of New Director CJCADR Professor (QBI) JürgenGötz South Wales)South organised theevent. University) and Professor Frank La Ferla (Uni- Ferla FrankProfessorLa and University) S ymposium
The exciting three-day program consisted of programthree-dayconsisted exciting The Jason Mattingley, Linda Richards, Pankaj Sah, Australia to attendtheconference. Allen Cheung, Garrido,Marta Geoffrey Goodhill, ( Neuroscience S Greg Stuart (ANU) and from QBI Group Leaders, (ANU), Michael Breakspear (QIMR), Peter (QIMR), Breakspear Michael (ANU), Berkeley), (UC Dan Yang (Champalimaud), of whom travelled internationally and acrosstravelled and whom internationally of SCiNDU was attended by 180 registrants, many ers including Mark Bear (MIT), Zach Mainen Zach (MIT), Bear Mark including ers speak - guest international severalfeatured an learn ro e per en e decode sensory information, makedecode sensory decisions, Mandyam Srinivasan andStephenWilliams. Local speakers included EhsanArabzadeh (UCL). Zhaoping Li and (UCL), Dayan Peter Robinson Robinson (Sydney), Marcello Rosa (Monash), presented and two tutorials. The conferencetutorials. The two and presented focused on understanding the computational onunderstandingthecomputational focused principles underlying how neural circuits e e er 15 1 2015 e on eren e e 2015 15 1 e e er lectures, a poster session with 70 posters 70 with session poster a lectures, the PROFESSOR GEOFFREY GOODHILL SCiND ystems & SCiNDU conference U) C omputational omputational D own Under own Under held at QBI from hosted hosted Queensland Brain Institute Annual Report 2015
Keynote speakers at the Cortical Connections conference hosted by QBI.
RECOG NITION Recognition International collaborations International QBI ANNUAL REPORT 2015 America, the United Kingdom, Europe, India and Japan. Japan. and India Europe, Kingdom, United the America, with scientists around the world, ranging across North world, North the across ranging around with scientists In 2015, researchers QBI continued to collaborate Johns HopkinsUniversity). fromProfessor (visiting Linzhao Chen SUSTC)and President for Education and Chair Professor of Biology, (Vice- Chuanyue SUSTC),Wu(President, Shiyi Chen Research Centre, SUSTC), Pankaj Sah, Perry Bartlett, Director,Neuro-Cognitive and Office Engagement Global(Director, Shengtao L–R:Hou Professors University of Science and Technology of China (SUSTC). Above: Research collaborationmeeting attheSouth University of Science and Technology of China. tions with neuroscience researchers at the South Automation (CASIA), QBI is strengthening connec of Institute Sciences’ of Academy Chinese the emy of Sciences’ Institute of Biophysics (IBP) and Acad University,Chinese Medical the Military In addition to joint laboratories with the Second olla orat on t re ear n t tute n na 2015 ALSO SAW of further developmentthe further of - -
or euro en e Munich Center the QBI—MCNsymposium. Munich Center for Neurosciences speaking at Founder,Grothe, Benedikt ProfessorAbove: neurons, circuits andcognition Constructing theintegrated brain: 3rd QBI-MCNSymposium community. findings with the Australian neuroscience ular neuroscienceto share theirrecent circuits, cognitive, and cellular and molec brought together leadingresearchers in symposium QBI—MCN successful The ic-specific sessions, and a poster session. top lectures, of series a included and daysthree over held programwas The t onal an lo alre ear er was attended by more than 130interna entre or euro en e third FROMOCTOBER 7 joint symposiumwiththeMunich – 9
its its hosted QBI - - - D Professor Bartlett Perry D partnerships with colleagues all over the world. Our scientists have strong international research • • • • • • • • • • • • • • r Timothy Bredy r Timothy r University of California, Irvine, USA University ofCalifornia,Irvine, Spitale, ProfessorAssistant Robert University ofGuelph, Canada A/Professor Boyer Winters, Kumar,Dr Arvind India CSIR-CCMB, Dr Haruhiko Bito, University of Tokyo, Japan of California,SantaBarbara, USA A/Professor Tod University Kippin, University Austria ofInnsbruck, A/Professor NicolasSingewald, of Scienceand Technology China,China Professor University South Shengtao Hou, Fudan University, China Professor Dongyuan Zhao, of Fundamental Research, India Professor ViditaVaidya, Tata Institute Medical University, China Neurogenetics Laboratory, Second Military Professor Huji Xu, JointSino-Australian ofBiophysics,China Institute Cognition, LaboratoryJoint ofNeuroscience and Professor RongqiaoHe,QBI-IBP Regents University, USA GeorgiaChen, Dr Bo-Shiun National University, Korea South Professor Se-Young Choi,Seoul Hopkins University School of Medicine, USA JohnsHuganir, The L Richard Professor V ictor Anggono
International collaborations International Professor ElizabethC H Associate Professor Thomas Burne Associate Professor • • • • • • • • • • • • elen Kumamoto University, Japan Dr Hiroshi Tawarayama, McGill University, Canada Dr Jean-Francois Cloutier, Health University Canada Institute, Aarhus University,Aarhus Denmark Professor Anders Nykjaer, of Singapore, Singapore SwedenandNationalUniversityInstitute, Professor Carlos Ibanez,Karolinska Charles University, Czech Republic Professor Jakob Hort, Dr CeciliaFlores, DouglasMental of California,SanDiego,USA Dr Jared Young, University of California,SanFrancisco, USA Professor ElliotSheer, University University,Aarhus Denmark Professor Preben Mortensen, Medical Center, The Netherlands Professor Jaddoe,Erasmus Vincent Dr Antony Isles,Cardiff University, UK State University ofNewYork, USA Professor Richard Gronostasjki, C ooper
oulson
Professor Professor RossC D Professor D Barry • • • • • • • • • • • • • • • • • •
r Allen Disease Control, USA Environmental andOccupational Dr Gayle Divisionof Windham, University, NewZealand Dr Pamela Von Massey Hurst, University ofCalifornia,Davis, USA ProfessorAssistant Rebecca Schmidt, ofHealth, USA National Institutes Dr UrsMeyer, Zurich, Switzerland ETH A/Professor Brian Lee, Drexel University, USA Dr Oliver Howes, Imperial College London, UK Karolinska Sweden Institute, Dr ElisabethFernell, Dr Erik Cederfjall, Lund University, Sweden Chile Universidad DiegoPortales, Professor David Huepe, for Research andEducation, Brazil Professor Jorge Moll,D’OrInstitute Medical University ofVienna,Austria Professor ChristianWindischberger, College,USA Dartmouth Professor Jeffery Taube, UK College London, Dr CaswellBarry, University Research USA Campus, Dr Gwyneth Card, HHMI Janelia of California,Berkeley, USA Professor KristinScott,University University,Columbia USA Professor Richard Mann, University ofCologne,Germany Professor Büschges, Ansgar C heung D arryl Eylesarryl
unnington
ickson
Professor D Massimo Associate Professor Professor • • • • • • • • • • DrPaolo Bazzicalupo andDrEliaDi • • • • • •
r Zhitao University ofMinnesota,USA Professor Sylvain Lesne, University ofNewcastle,UK Professor JohannesAttems, of Cologne,Germany Dr Christoph Köhler, University of Sciences,China of Neuroscience, ChineseAcademy Professor ZhiqiXiong,Institute and Research (IISER), India ofScienceEducationIndian Institute ProfessorAssistant Kavita Babu, Cornell University, USA A/Professor Jeremy Dittman, ofBiophysics,China Sciences, Institute Professor Tao Xu, ChineseAcademy of Harvard University, USA Professor Josh Kaplan, Harvard University, USA Professor YunZhang, University ofColorado, USA Professor Ding Xue, of Institute Technology, USA Professor Hang Lu, Georgia Bioresources, Italy Schiavi, ofBiosciencesand Institute Professor Hannsjörg Schröder and Dr MatthiasStaufenbiel, DZNE, Germany Professor Mel Feany, Harvard University, USA University UK CollegeLondon, University ofCardiff, UK Hu H G J illiard ürgen eoffrey
G
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International collaborations International Professor Professor Professor Professor Tianzi • • • • • • DrChristinaDalman andDrRenee • DrHenning Tiemier andDrVincent • • • • • • • • StemCellandBrain Research • • School ofPharmacy, Denmark Dr StephanPless,Danish of California,LosAngeles, USA Professor Richard University Olsen, University,Columbia USA Professor NeilHarrison, University ofAlabama, USA Professor Andrew Jenkins, University ofWurzburg, Germany Professor CarmenVillmann, University UK CollegeLondon, Dr BrianLee,Drexel University, USA Gardiner, Karolinska Sweden Institute, Netherlands Jaddoe, Erasmus MedicalCentre, Psychiatry, UK Kings CollegeLondon, Dr Fiona Gaughran, of Institute University,Aarhus Denmark Centre forRegister-based Research, Professor National Preben Mortensen, Survey, Harvard MedicalSchool,USA Professor Ron Kessler, World Mental Health Trinity Ireland CollegeDublin, Dr Redmond O’Connell, University ofRegensburg, Germany Professor Mark Greenlee, University UK ofCambridge, Dr Tristan Bekinschtein, Professor RobHarvey, France INSERMU846, Institute, Juelich Research Center, Germany J J J ohn McG ason Mattingley oe Lynch Queensland Brain Institute
J Annual Report 2015 Annual Report
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Recognition Recognition International collaborations International QBI ANNUAL REPORT 2015 Professor Pankaj Professor Linda Richards D D • • • • • • • • • • • • • • • • r MichaelPiper r of Sciences,Beijing of Biophysics,Chinese Academy Professor Institute JianyuanSun, of Scienceand Technology ofChina Professor Shengtao Hou, South University Meischer Research Switzerland Institute, Professor Andreas Luthi, Fredrich FranceINSERM U846, Professor Alessandra Pierani, University SchoolofMedicine,Japan Professor Hideuki Okano,Keio State University ofNewYork, USA Professor Richard Gronostajaki, University ofWashington, USA Professor William Dobyns, of California,SanFrancisco, USA Professor James Barkovich, University of California,SanFrancisco, USA Professor Elliott Sherr, University University ofOtago,New Zealand Associate Professor ChristineJasoni, State University ofNewYork, USA Professor Richard Gronostajski, Stanford University, USA ProfessorEmeritus MatthewScott, forMedicalResearch,Institute UK Professor Francois Guillemot, MRC National Research Centre, Singapore David Townsend, ClinicalImaging University Hospital, Singapore Professor Allen Yeo, National San Diego,USA Neurosciences, University ofCalifornia, Professor Edward of Koo, Department F atima Nasrallah S ah
Professor Peter Bruno van S Associate Professor Professor Mandyam S • • • • • • • • • • • • •
Harvard University, USA of Organismic andEvolutionary Biology, of California,SanFrancisco, USA Professor JohnWitte, University University ofWashington, USA Professor BruceWeir, Harvard USA &Berlin, &Germany for StatisticalAnalysis, Consortium Dr StephanRipke, Psychiatric Genomics for Schizophrenia, Wales Psychiatric Genomics Consortium Professor Mick O’Donovan, of Amsterdam, Netherlands Genetic Association Consortium, University Professor Phillip Koellinger, Social Sciences University ofColorado, USA ProfessorAssistant MattKeller, Harvard, USA (GIANT) Consortium, Investigation ofAnthropometric Traits Professor Genetic JoelHirschhorn, University ofEdinburgh, Scotland Professor BillHill, University ofLiege,Belgium Professor MichelGeorges, of Edinburgh, Scotland University Cohort, of theLothianBirth Professor IanDeary, The Epigenome Professor Li Liu, Institute of Biophysics, China University SchoolofMedicine,USA Assistant Professor Paul Shaw, Washington Bhagavatula, Department Dr Partha winderen
V
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Professor NaomiWray Margie Wright Associate Professor • • • • • • • • • • • Chemical Senses Center,Chemical Senses USA Professor DanielleReed, Monell Consortium ENIGMA Germany Health, ofMental Mannheim, Institute Central Consortium, (IMAGEMEND) GEnetics forMENtalDisordersIMAging Professor Andreas Meyer-Lindenberg, California,USA of Southern Analysis (ENIGMA) University Consortium, Meta Genetic through Imaging Neuro Twin Imaging Study (QTIM) and Enhancing Queensland Thompson, Paul Professor Sweden Institute, Carolina, USA &Karolinska of North Professor Patrick Sullivan, University for Consortium Lithium Genetics, Germany International Schulze, Professor Thomas Harvard University, USA Professor Soumya Raychaudhuri, Universiteit Amsterdam, Netherlands Professor Brenda Penninx, Vrije Washington University, USA Professor ElliotNelson, University, USA Disorders, Virginia Commonwealth for Genetics ofAnxiety Consortium Professor JackHettema, International of Edinburgh, Scotland University Cohort, of theLothianBirth Professor IanDeary, The Epigenome
J Associate Professor • • • • • ian Yang of California,SanFrancisco, USA Assistant Professor Noah Zaitlen, University Harvard University, USA Associate Professor Alkes Price, Wenzhou MedicalUniversity, China Professor ZibingJin, University ofExeter, UK Traits (GIANT) Consortium, Investigation ofAnthropometric Professor Timothy Frayling, Genetic CornellUniversity,Consortium, USA Sciences Genetic Association Professor Social DanielBenjamin,
UQ appointmentsUQ Perry Bartlett Perry Professor H Associate Professor Mr Thomas Burne Associate Professor • Health andMedicalResearch • • • • • and Systems Enhancing • Anatomical Biosciences • • Anthropology Museum • • Academic Board • elen Management GroupManagement University Senior Advancement Board BoardImaging Advisory Co-ordinator MPhil inNeuroscience Program Co-ordinator Master ofNeuroscience Committee BiosafetyInstitutional Consultative Group UQ Information Technology Project Team Member Animal Ethics Services, BMember Chair andCategory Animal EthicsCommittee, Centre forAdvanced Committee Management Advancement Sub-Committee J ake C ooper C aroll
Elizabeth Professor Mr Massimo Associate Professor Professor G Professor Professor Vice-Chancellor’s Risk • • • • BiologicalResources • • UQBRAnimal Users • Anatomical Biosciences • • • eoffrey Compliance Committee Staff Consultative Committees Professional and Academic Infrastructure Sub-Committee National ImagingFacility Committee Library Committee Advisory Committee Advisory Animal EthicsCommittee Vice-Chair Committee, Small Animal Imaging Centre forAdvanced Imaging Committee andPromotionsAppointments ChairofLocal Deputy J ohn Kelly G C H J
D oodhill oulson illiard illiard ürgen arryl Eylesarryl G ötz S Professor Professor Pankaj Linda Richards Professor D J Professor Professor Research Higher • • UQResearch Committee • • and Systems Enhancing • • UQResearch Committee • • Animal EthicsCommittee • • • UQ appointmentsUQ ohn McG tephen Williams r Michael Piper Degree Committee Neuroscience, Director Australian inAdvanced Course Committee Management University Senior Discovery Committee Services Child Health @UQCommittee Committee Directors (Research) Deputy Deans/Institute Associate Deans/Deputy Health Research, Director CentreQueensland forMental Research Advisor Integrity Queensland Brain Institute rath J Annual Report 2015 Annual Report oe Lynch
G O C E R S ah NITION
Recognition Recognition QBI ANNUAL REPORT 2015 Professional service Professional D Professor Bartlett Perry D • • • • SpinalCure Australia Director • • • MaterMedicalResearch Institute • • • • • •
r Timothy Bredy r Timothy r Grant Reviewer ofHealth Research,Canadian Institutes Luxembourg, Grant Reviewer Fonds NationaledelaRecherche, Grant Reviewer European Horizon Commission 2020, France, Grant Reviewer Agence Nationale delaRecherche, Boardand Scientific Chairman BoardAdvisory Member Science ofLearningResearch Centre, of Australia, Research Committee Motor Neurone DiseaseResearch Institute Limited, Board ofDirectors, Member PromotionsAppointments and Committee University ofNewSouthWales, Scientific InstituteofMedicalResearch, Garvan Boardof Auckland, Scientific Advisory Centre forBrain Research, University Committee Advisory of Sciences,Beijing, International Automation, The ChineseAcademy Brainnetome Center, of Institute Zealand, Project Grant Reviewer Health Research New Council, NHMRC Project Grant Reviewer V ictor Anggono
Professor ElizabethC H Associate Professor Thomas Burne Associate Professor • • • • • • • Alzheimer’s Australia Dementia • Australian Huntington’s Disease • • • • •
elen The MasonFoundation Board Scientific NHMRC Assigner’s Academy Member Summer School,Organising Committee SocietyforNeurochemistry International and MedicalPanel Member Research Foundation, Scientific Australasian Neuroscience Society Representative,Queensland Health ResearchSociety ofMental Local organising forthe committee NHMRC Assigners Academy for Neuroscience, CommitteeMember Brisbane ChapteroftheAmerican Society QBI Representative Association, Queensland Branch, Queensland Association, Member Committee Rebecca LCooperFellowship, Research Fellowship Panel Member Representative,Queensland Early Career Health Research,Society forMental NHMRC Grant Review Panel Member Member andCommittee Secretary Australia,Biological Psychiatry C ooper
oulson
Professor RossC Professor Professor D Barry • • European Biology Molecular • • • • HHMI JaneliaResearch Campus • • • International 2016 BIOMAG • • Corresponding Member Austrian Academy ofScience, Advancement ofScience,Fellow American Associationforthe Organization, Member The MalleableBrain, Co-organiser FlagshipNeurochemistry School: Scientific ReviewScientific Committee NSW Brain Bank Network, Vice-President Australia,Biological Psychiatry Societyfor International Co-organiser Workshop onMotor Control Circuits, of Drosophila, Co-organiser Neural Circuits andBehaviour EMBO-Kavli Workshop on Committee Scientific Neuroscience Netherlands, 2017, ConferenceInternational onCognitive Korea, ScientificCommittee Conference onBiomagnetism, Society, Executive Committee Australasian Cognitive Neuroscience D arryl Eylesarryl unnington ickson
Professor Tianzi Massimo Associate Professor Professor Professor • • • • • • • • • • • • • •
Imaging, Scientific Committee Chair Committee Imaging, Scientific Tianjin Key Laboratory of Brain Functional Member Committee Scientific ofEducationof theMinistry ofChina, Key Laboratory forNeuroInformation Member Committee Scientific Chinese Academy ofSciences, ofAutomationInstitute ofthe Chair Deputy Committee and Therapy ofPsychiatry, Scientific Hunan Key Laboratory ofDiagnosis Science, Board ofDirectors Member Chinese SocietyforCognitive Standing MemberofBoard ofDirectors Chinese SocietyforAnatomical Sciences, for Anatomical Sciences,President Brainnetome Branch of the Chinese Society NHMRC Grant Review Panel Panel Advisory Research, Expert forDementia NHMRC NationalInstitute (EU Initiative), Grant Review Panel Joint Project Neurodegenerative Diseases FellowshipsDementia Grant Reviewer NHMRC andARC Grant Reviewer Alzheimer Research Forum, Member NHMRC Grant Review Panel H J G illiard ürgen eoffrey J G iang ötz G oodhill
Professional service Professional Professor Professor • • • • • • • • • Congress, Programming Committee SocietyforNeurochemistry International of Basic andClinicalPharmacology, Chair Committee forBrainCommittee andMind,Member Australian Academy ofScience,National Member Committee and itsDisorders, Advisory Scientific ARC Centre ofExcellence forCognition ARC CollegeofExperts Member Council Advisory Performance, Association forAttention and Education) Member Committee Panel D(Psychology, SocialMedicine, Academy ofSocialSciencesinAustralia, Union oftheInternational Committee Glycine Receptor Nomenclature Society, Secretary Australasian Neuroscience GroupAdvisory Member Neuroscience, Program Scientific Australian inAdvanced Course J J ason Mattingley oe Lynch
Professor Linda Richards D Professor • • • • • • Schizophrenia Research International • Research Australia Board Member • • • • • • •
r Michael Piper NHMRC Grant Review Panel (AusDOCC),Callosum Scientific Advisor Australian Disorders oftheCorpus NHMRC Assigners Academy, Member RepresentativeQueensland Australasian Neuroscience Society, Cell andDevelopmental Biology, Treasurer Australian andNewZealand Societyfor BoardAdvisory Member Schizophrenia Research Forum, Society, Board Member Research Committee YouthOrygen Health Research Centre, NHMRC Grant Review Panel Member NHMRC Research Committee Ethics Committee NHMRC Australian Health Program Review Committee ANZ Trustees Medical Queensland Access Committee Australian Schizophrenia Research Bank, J ohn McG
rath
Professor Pankaj Professor Peter Professor Mandyam S • • • World Congress Psychiatric Genetics • SocialScienceGenetics Association • • • • • • • • • • and Automation, Program Committee Australasian Conference onRobotics Board Advisory Scientific Harbor AsiaCold Spring Conferences, Research Evaluation Committee Advisory Committee Committee Advisory ofMedicalResearch),Institute Strategic of Health/Garvan (NSW Department Medical Genomics Reference Bank ScientificCommittee Jerusalem, 2016, Board Advisory Consortium, of Edinburgh, Member Cognitive Epidemiology, University Centre forCognitive Ageing and “Black Boxes”, Member Working Groupfor Evaluation ofGenomic Committee Advisory Medical Services National ICT Australia Ltd, AustralianCouncil, AcademyofScience Centre, Executive Committee Science ofLearningResearch Fellowship Panel NHMRC Career Development NHMRC Assigners Academy, Member Grant Review Panel Member Multiple Sclerosis Australia, Committee Neuroscience, Management Course Australian inAdvanced Course V isscher S ah
rinivasan
D J Associate Professor Margie Wright Associate Professor Professor NaomiWray Professor • • • • World Congress Psychiatric Genetics • World Congress Psychiatric Genetics • • • • • • ian Yang
r Scientific Advisory GroupScientific Advisory Member Consortium, Meta Analysis (ENIGMA) Enhancing Neuro Imaging through Genetic Cell andDevelopmental Biology, Member Australia andNewZealand Societyfor Genetics SocietyofAmerica, Member NHMRC Grant Review Panel Committee Orlando,Scientific 2017, Committee Scientific Jerusalem, 2016, Genetics,for Lithium Advisor Consortium Board Scientific Advisory Anorexia Genetics Initiative, Nervosa of Genomic “BlackBoxes” WorkingCommittee Groupfor Evaluation Advisory Member ofthe MedicalServices NHMRC Research Fellowship Committee NHMRC Grant Review Panel S Professional service Professional teven Zuryn S tephen Williams Queensland Brain Institute Annual Report 2015 Annual Report G O C E R
NITION
Recognition People QBI ANNUAL REPORT 2015 Annual Institute Lunch. QBI staff at the 2015 2015 the at staff QBI
People Whether researcher, student, or professional staff QBI is home to more than 450 staff and students. and staff to than 450 more home is QBI in the success of the Institute. member, each individual plays an important role Queensland Brain Institute Annual Report 2015 Annual Report P EOPLE
People People e e ut e an a l ate a ult QBI ANNUAL REPORT 2015 D D D John Kelly Professor LindaRichards Professor Pankaj Sah Professor Pankaj Sah Professor Bartlett Perry eputy eputy irector (until 30June2015) (until (commenced 1July2015) 30June2015) (until (commenced 3August 2015) D D irector (Operations) irector (Research)
F Associate Professor JianYang Associate Professor Margaret Wright Associate Professor van Bruno Swinderen Associate Professor MassimoHilliard Associate Professor Eyles Darryl Associate Professor HelenCooper Associate Professor Kai-Hsiang Chuang Associate Professor Thomas Burne Dr Steven Zuryn Professor Huji Xu Professor NaomiWray Professor Stephen Williams Dr JanaVukovic Professor Peter Visscher Professor Mandyam Srinivasan Professor Pankaj Sah Professor Linda Richards Dr MichaelPiper Mr Geoffrey Osborne Dr Fatima Nasrallah Professor Mowry Bryan Professor Frederic Meunier Professor JohnMcGrath Professor JasonMattingley Professor Marshall Justin Dr MarieMangelsdorf Professor JosephLynch Professor Jiang Tianzi Dr ZhitaoHu Professor Geoffrey Goodhill Professor Juergen Goetz Professor Dickson Barry Professor RossCunnington Professor ElizabethCoulson Dr Allen Cheung Bredy Dr Timothy Professor Bartlett Perry Dr Victor Anggono aculty (Conjoint Appointment) (Conjoint Appointment) (Conjoint Appointment) (Conjoint
Adjunct appointments University ofQueensland affiliates Associate Professor Yajing Sun Associate Professor Grant Montgomery Associate Professor Geoffrey Faulkner Associate Professor Peter Noakes Associate Professor JulieHenry Associate Professor Paul Dux Associate Professor Terrence Coyne Sujit John Dr Steven Zuryn Dr ZhengyiYang Dr Robyn Wallace Dr Rangaswamy Thara Dr ShuichiSuetani Dr CorneliaStrobel Dr Weichuan Mo Professor Geofferey Masters Dr Riccardo Marioni Dr BillMantzioris Dr Hong Lee How Dr Martin Dr ZiarihHawi Dr Yakir Gagnon Dr TarrantCummins Dr Gabriela-Oana Bodea Professor MarkBellgrove Dr JeffBednark Dr SamuelNayler Dr Stanley Millard Dr David Kvaskoff Dr Marc Kamke Professor Wayne Hall Dr Hannah Filmer Dr Fabio Cortesi Dr Brett Collins Dr Karen Cheney Capon Professor Robert Professor MatthewBrown Dr Marie-JoBrion H Emeritus Professors C Professor CharlesWatson Professor Seong-Sen Tan Professor Lesley Rogers Professor Tristan Perez Professor Hideyuki Okano Professor NicholasMartin Professor OttmarLipp Professor Gisela Kaplan Professor Christian Gericke ProfessorCollin Shaun Professor Charles Claudianos Professor Mark Bellgrove Professor David Adams Professor David Vaney Professor Jack Pettigrew Dr Rachel Suetani Saha Dr Sukanta Dr SathishPeriyasamy Dr DuncanMclean Dr Oressia Zalucki Dr LataVadlamudi Dr Jeremy Ullmann Professor Walter Thomas Dr Hari Subramanian Singh Dr Surya Professor Peter Silburn Dr JiShin Dr SoniaShah Dr EthanScott Dr Marc Ruitenberg Dr Eva-Maria Reuter Professor David Reutens Dr MelodyPuckridge Dr JosephPowell onjoint appointments onorary Professors QBI researchers QBI Academic titleholders Research officers H Associate Professor Associate Professor Michael Wilson Xiang Li Samuel Nayler Dr JudithReinhard Dr Thai VinhNguyen Dr David Kvaskoff Dr ChristineGuo Dr TonyDreise Leonie Kirszenblat Matthew Robinson onorary researchers Robert Henderson Robert
Research assistants Postdoctoral fellows Tim Butler Julia Groening Yu Chau Arne Brombas Andrew Bakshi Andrew Baker Alan Goldizen Cheryl Filippich Cheryl Suzanne AlexanderSuzanne Stephanie Bell Dr KaiFeng Dr Argel Estrada Dr NelaDurisic Dr ChristineDixon Dr SimonDeCroft Dr Fanny deBusserolles Dr Xiaoying Cui Dr Alexandre Cristino Dr Florence Cotel Dr Lavinia Codd Dr Luca Cocchi Dr SeanCoakley Dr Wen-Sung Chung Dr Guo-BoChen Dr MarieCamara Dr EndaByrne Bunt Dr Jens Dr Arne Brombas Dr Marie-JoBrion Dr LiviuBodea Dr DanielBlackmore Gonzalez Bertran Dr Jesus Dr Beben Benyamin Dr JeffBednark Dr Oliver Baumann Dr CorinneBareham Dr LilachAvitan Dr Eleonora Autuori Kathy Asmussen Kathy Asmussen Brookes Folmli Ka Fok Lee Fletcher Linda Cumner Rachel Gormal Justine Haddrill Justine Andrew Martin Andrew Martin KumarApurva Anna Kleine Alexander Holloway Amy Heffernan Gregory Medley Chang Liu Oscar Jacoby Simranpreet Kaur Dr Wei Luan Dr JingLu Dr Luke Lloyd-Jones Dr Haowen Liu Dr Yonghui Li Dr LeiLi Li Dr Chuanzhou Dr Hong Lee Dr Aoife Larkin Dr Vanessa Lanoue Dr Peter Kozulin Dr Georg Kerbler Dr Angelo Keramidas Dr Marc Kamke Dr MerjaJoensuu Dr DhanishaJhaveri Dr MdRobiulIslam Hatch Dr Robert Dr WilliamHarrison Dr Jake Gratten Grabowska Dr Martyna Dr Helen Gooch Dr IlanGobius Dr RosinaGiordano-Santini Dr JeanGiacomotto Garrido Dr Marta Dr Yakir Gagnon Dr Javed Fowdar David Lloyd Benjamin Lewis Laura Leighton Pauline Ko Michael Knight Kyra Hay Timothy Reeks Thomas Pollak Tishila Palliyaguru Tam Nguyen Zoie Nott Abbey Nydam Vikram Ratnu Gregory Robinson Gregory Robinson Imogen O'keeffe Dr IngoSchiffner Dr MiriamSanchezMatamales Sale Dr Martin Dr PhilipRobinson Dr MatthewRobinson Dr Margaretha Ridder Dr LeiQian Dr Alexander Puckett Dr JosephPowell Dr JuanPolanco Dr Andreas Papadopulos Dr Pranesh Padmanabhan Dr KathieOvereem Odabaee Dr Maryam Dr ConorO'leary Dr Christopher Nolan Dr Rebecca Nisbet Dr ShyuanNgo Dr Brent Neumann Dr Ramesh Narayanan Dr Gerhard Moser Dr JohnMorris Dr Divya Mehta Dr EllenMeelkop Dr Allan Mcrae Dr Ramon Martinez-Marmol Dr SallyMartin Dr RogerMarek Elise Rowe Fiona Ritchie Dr ZacPujic Matthew Pelekanos Kelsey Palghat Rachel Petro Michael Milne Zong Zhang Zala Skrbis Yi Wang Amanda White Andrea Tweedie Dr ZhihongZhu Dr QiongyiZhao Dr Futao Zhang Dr François Windels Dr NicoleWilson Dr JocelynWidagdo Dr Wei Wei Dr TongWang Dr Anna Vinkhuyzen Fabrice TurpinDr Dr Maciej Trzaskowski VanesaDr Tomatis Hanne Thoen Dr Chanel TaylorDr Dr Matthew Tang Men TanDr Sullivan Dr Robert Dr RodrigoSuarez Dr CorneliaStrobel Dr Peter Stratton Dr Sara Stieb SrourDr Hussein Dr Benjamin Sivyer Dr Konstantin Shakhbazov Dr SoniaShah Hasti Ziaimatin Li Xu Hong Vo Biao Sun Dean Soccol Heather Smith Peter Smartt Simila Henry Petra Sedlak Bree Rumballe Richard Wang QBI researchers QBI Queensland Brain Institute Annual Report 2015 Annual Report P EOPLE
People People QBI students QBI ANNUAL REPORT 2015 PhD Laura Fenlon Ilvana Dzafic Alessandra Donato Daina Dickins Aymeric Denuelle Nadia Cummins Baptiste Couvy-Duchesne Lavinia Codd Kok SiongChen Chaplin Justin Ye JinChai Megan Campbell Zoran Boskovic Nicholas Bland Stephanie Biergans Brendan Bicknell Bhaga-Madhusoothanan Siân Baker Danay Baker-Andresen BademosiAdekunle Mohammed Atif Joon Yong An Almarza Gonzalo Asad Ali Al-Amin Md Mamun vathi Perumal students Jonathan Lim Gerhard Leinenga Emilia Lefevre Natalie Lee Kiaran Lawson Michael Langford Elizabeth Kita Leonie Kirszenblat Kooi Yeong Khaw Georg Kerbler Ravi Kiran Kasula Kassam Irfahan Debajyoti Karmaker Jeans Rhiannon Se EunJang Oscar Jacoby Sarah Hunt Samuel Hunt Nicholas Hughes Luke Hearne HarrisAnthony Samuel Harley Sumasri Guntupalli Natalie Groves Andrea Giorni Lee Fletcher Reuben Strydom Lachlan Strike Ashvin Srinivasan Paola Spadaro Ming ShiuanSoh Cooper Smout Chase Sherwell Michelle SanchezVega Natalie Rens Chikako Ragan Genevieve Phillips Alice Petty Annalisa Paolino Morgane Nouvian Huyen Nguyen Vinod Narayana John Morris Laura Morcom Aung Aung Kywe Moe Andrew Martin Mahadeeswara Mandiyam Maier Robert Anne Maallo Luhrmann Martin Xiang Li Cirong Liu Xiaoqing Zhou Mei Zhou Jing Zhao Yan Zhang Oressia Zalucki Hon Yap YanShanzhi Yuanhao Yang Xianfeng Yang Di Xia Yang Wu Tong Wu Lisa Wittenhagen Sarah Williams Michelle Watts VallergaCostanza Karly Turner Marion Turnbull Michael Troup Susan Travis Hanne Thoen Rachel Templin Gavin Taylor Sahil Talwar Kristin (Chia-Hsuan) Sung Yajie Sun MPhil students Loc-Duyen Pham Jennifer Pavlides Lacey Atkins QBI professional staff professional QBI and graphics communications Advancement, commercialisation Research legal and S publications G Institute Manager Dr NickValmas Katherine Robbins Andrea Markey KoreisDarius Rachael Kelly Katie Francis Bernadette Condren Carolyn Barry Mikaeli Costello and Communications Director ofAdvancement Stephanie Surm Rowan Tweedale DaySusan Dr Sylvie Pichelin Publications Manager Grants, Ethicsand Helen Weir enior Research Manager rants, ethicsand
Information technology Executive office Laboratory support Dr Alan Woodruff Rebecca Harvey Donna Lu Elizabeth Cooper-Williams Ashley Cooper Alison van Niekerk Executive OfficeManager Janette Zlamal Dr RobSulllivan RaghuwanshiAnshu Emma Palfreyman Virginia Nink Nicholas Nacsa Dr DanielMatthews Donna Martin Luke Hammond Janette Edson Chien Arthur Maria Caldeira Tania Brooks Judy Bracefield Dr DanBlackmore John Baisden Dr RumeloAmor Clare Seaman Manager Scientific Services Gary StrachanGary Michael Simpson Matt Savage Irek Porebski Alex Kowalczyk KollmorgenPerry Lyndon Cook(Acting) Jake Carroll IT Manager H Technical services S health andsafety Occupational F John Steptoe Brandon Horne Ethan Park David Wheeldon Technical Manager Services Penny Storey Linley Martin Catherine MacAuley Janet Voight Administration Manager Postgraduate Student Ross Dixon Li Peng Reeza Nazer Esmeli Quevedo Baquero Michael Perren Chad Lake Wade Ebeling Anna Brancatini Anthony McRae Planning Manager Finance Analysis and Nicole McDonald Kristy Hume Emma Read Maria Cummings Jackie Perren Samantha Dyson HR Manager inance and store tudent adminstration uman resources
and C Ageing C Research S Administrative support Earlene Ashton Anjali Henders Human StudiesUnitManager Campbell Suzanne Jo Sutton Centre Manager Jennifer MacNevin Annita Nugent Chief Operating Officer Deirdre Wilson Donna Simon Charmaine Paiva Roxanne Jemison Sinead Eyre Earnshaw Susan Campbell Suzanne Megan Alexander cience of Learning cience ofLearning entre forNeurogenetics lem QBI professional staff professional QBI S tatistical J ones D ementia Research C entre C Queensland Brain Institute entre for entre for G enomics Annual Report 2015 Annual Report
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People People Acknowledgements QBI staff QBI ANNUAL REPORT 2015 section mountingbrush,electroporation forceps, andapencil. collection of patch pipette, a pick used to manipulate Above: QBI tools of the trade (L–R): a digital stylus, an electrophysiology are greatly appreciated.your efforts time, valuable or text images, was it Whether Report. Annual Thank you to all QBI and UQ staff who contributed to the 2015 Drosophila, a tissue punch for sample extraction, a histology , , elegans C. a pooter used for the Project Manager Annual Report Dr NickValmas
C D Mikaeli Costello Dr NickValmas Bernadette Condron Donna Lu Chief copywriter Dr NickValmas opywriters esign Editors Dr Alan Woodruff Alison van Niekerk Kirsten MacGregor Mikaeli Costello Bernadette Condron Dr Nick Donna Lu Chief editors Valmas Photography Donna Lu KoreisDarius Dee McGrath Dr Nick Chief Photographer Valmas
Queensland Brain Institute 2015 Annual Report
Queensland Brain Institute Phone: +61 7 3346 6300 /QldBrainInstitute Building 79, St Lucia Campus Fax: +61 7 3346 6301 The University of Queensland Email: [email protected] @QldBrainInst Brisbane QLD Australia 4072 Web: www.qbi.uq.edu.au Queensland Brain Institute