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Queensland Brain Institute 2018 Annual Report Vice-Chancellor’S Message

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Queensland Brain Institute 2018 Annual Report Vice-Chancellor’S Message Queensland Brain Institute 2018 Annual Report Vice-Chancellor’s message The Queensland Brain Institute was established in response to two of the greatest challenges in modern science: understanding brain function and the prevention and treatments of disorders of brain function. QBI’s 450-plus research staff cohort includes dynamic group leaders, postdoctoral fellows and students, all working together to tackle these challenges. Their discoveries are regularly published in top-tier scientific journals. Indeed, the 2018 Excellence in Research for Australia (ERA) results reinforce the quality of QBI research. As in all previous ERA assessments, UQ’s neuroscience was rated “well above world standard”. This is the highest possible rating and was secured largely due to Professor Peter Høj QBI researchers’ work. Vice-Chancellor and President In the past 12 months, this team of researchers has made impressive progress. To begin, QBI has done a magnificent job advancing (EAIT) had existing links with this emerging university its promising ultrasound project. Professor Jürgen in a technological boom city. Now, SUSTech and UQ Götz and his team at the Institute’s Clem Jones are close to jointly establishing a neuroengineering Centre for Ageing Dementia Research are developing laboratory and a Master in Bioengineering, to be a device that delivers ultrasound to the brain through run through EAIT. This multifaceted relationship the skull, helping drugs and other therapeutics reach between UQ and one of the world’s most rapidly their targets more effectively. This team demonstrated rising universities offers exciting, transformative for the first time in 2015 that ultrasound can have a scientific potential. therapeutic effect on mice with Alzheimer’s disease. Now, just a few years later, the team has partnerships In a difficult environment, QBI researchers continued with medical-device engineers and clinicians, and their success in competitive funding schemes. will begin human-safety trials soon. The project In National Health and Medical Research Council exemplifies what QBI is about: in collaboration with project grants, QBI’s 35 per cent success rate commercial partners and clinicians, the institute takes compares to a 17 per cent national average. In basic neuroscience discoveries as the basis to develop Australian Research Council Discovery grants, new approaches to brain disease, leading to clinical QBI’s 33 per cent success rate compares with trials and ultimately treatments. the 22 per cent national average. It was an important year for the Clem Jones Centre Meanwhile, much-valued industry and clinical for Ageing Dementia Research in other ways too. partners continue to work with and support the The centre’s significant effort to secure funding for Institute. QBI was established 15 years ago and the the next five years was rewarded with a $10 million occasion was celebrated with an event at Customs Australian Government commitment and a $5 million House in October last year. Executives from the wider Queensland Government pledge for the ultrasound University, past and present QBI staff, donors and project. Donations of several million dollars included others who have contributed to the Institute’s success gifts from The Clem Jones Foundation and The Brazil gathered to mark its standing as a world-class Family Foundation. I was pleased to add strategic neuroscience research centre. University funding towards Professor Götz’s team It is a privilege to lead a university with the capacity and their outstanding research that continues to to create change in many ways. QBI’s excellent draw global attention. research, commitment to strategic partnerships Internationally in 2018, QBI Director Professor and efforts to secure diverse financial support Pankaj Sah and colleagues renewed and strengthened exemplify qualities we promote across UQ. agreements with Japan’s RIKEN Center for Brain Congratulations to Professor Sah and his team Science and the Chinese Academy of Sciences’ on their tremendous achievements this year. I look Institute of Neuroscience. These are important forward to QBI maintaining its upwards trajectory outcomes from the Institute’s strategic focus in the next 15 years. on developing top-level neuroscience research collaborations globally. QBI also strengthened UQ’s relationship with the Southern University of Science and Technology (SUSTech) in Shenzhen, China. UQ’s Faculty of Engineering, Architecture and Information Technology Queensland Brain Institute Annual Report 2018 1 Director’s message (also in collaboration with UQ’s Faculty of Engineering, Architecture and Information Technology), and a joint neuroengineering laboratory. The two-part program will complement a relationship we have formed with Shenzhen’s Bao’an District Hospital, which will provide training in deep brain stimulation surgeries to local surgeons and neurologists. Another major strategic focus was to secure continued funding for the Clem Jones Centre for Ageing Dementia Research (CJCADR) and to raise capital for the development of an ultrasound-based device for the treatment of Alzheimer’s disease. In its June Budget, the Queensland State Government committed $5 million towards this, followed by a Professor Pankaj Sah Director $10 million pledge from the Federal Government. In a reversal of roles, we were also delighted this year to present Queensland Science Minister Leeanne Enoch with QBI’s first commercial return 2018 was another highlight-filled year for the Institute, from the Institute’s activities. This was based on as we continue to grow our reputation as a leading the development of a new drug candidate for motor neuroscience centre in the Asia-Pacific region. neurone disease, work that Emeritus Professor Perry There were significant accomplishments in research Bartlett and Emeritus Professor Andrew Boyd of funding and awards, faculty recruitment, student UQ and QIMR Berghofer began over a decade ago. training, strategic partnerships, translation and commercialisation, infrastructure, facilities and 2018 also saw continued improvements to our resources, and community engagement. By physical infrastructure. The breakthrough from the any measure this was a year to be proud of. CJCADR space in the QBI building to Level 3 of the adjacent Ritchie building was completed, providing The accomplishment of our researchers in securing a walkway between these spaces. We also finalised competitive grants shows no sign of slowing. Our the fitout of our clinical rooms in Ritchie, which success rates in both the NHMRC Project Grant and ARC include a Memory Clinic for testing patients with Discovery Grant rounds continue to be well ahead of the neurodegenerative disease, and a small room national averages, and are detailed within this report. equipped for taking blood samples. It is not just our researchers that contribute to QBI’s Finally, the International Research Review Board success, and so we were delighted that two members undertook their second visit to QBI in December, of our IT team—Jake Carroll and Irek Porebski—won following an earlier trip in 2017. The IRRB has now their second Gold Award at the Australian Computer reviewed all QBI faculty and have offered some Society Digital Disruptor award ceremony. well-considered recommendations that QBI will Several new appointments in 2018 brought new expertise look to implement in the coming years. The timing to QBI in areas of strategic focus. Dr Susannah Tye was of this is fortunate, as QBI is scheduled for its 7-year recruited from the Mayo Clinic as a Senior Research Academic Board Review in 2019. This is a great Fellow in Neuromodulation. Susannah will link closely opportunity to reflect on all that the Institute has with the deep brain stimulation expertise we have within accomplished in recent years, but also to map a path our Asia Pacific Centre for Neuromodulation. Dr Zhaoyu that brings us even more success in the years ahead. Li joined us from the University of Michigan as the In closing, I wish to extend my thanks to UQ’s Vice- inaugural Bartlett Fellow, and will be part of a growing Chancellor Professor Peter Høj and Provost Professor team of QBI researchers who use Caenorhabditis elegans Aidan Byrne for their staunch support. I am also as a model system. Dr Adam Walker joins us from indebted to Mr Jeff Maclean and all other Advisory Macquarie University as the new Ross Maclean Fellow Board members for their wise counsel. Thanks also and will boost our strength in motor neurone disease to my Deputy Directors: Professor Linda Richards research. Finally, we also welcome Associate Professor (Research), Mr John Kelly (Strategy) and Ms Helen Gail Robinson as a joint appointment with the School of Weir and Ms Stephanie Surm (Operating; Helen to Psychology. Gail brings expertise on the neurocognitive August, and Stephanie from August to year-end) aspects of dementia and her work will complement the for their commitment to the Institute. Helen has now activities within CJCADR. taken up a senior management role at QUT, whilst There were also significant developments in some John Kelly is retiring in early 2019 after a stellar 39 of our larger strategic activities. Our partnership with years of service to UQ. Last, but by no means least, the Southern University of Science and Technology my thanks go to all at QBI for your ongoing (SUSTech), in Shenzhen, China, is progressing well contributions to our successes. I am looking forward in two respects: a joint program in Neuroengineering to another
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