2014 ANNUAL REPORT Understanding CONTENTS DISEASE THE YEAR IN REVIEW RESEARCH LABS & GROUPS Chairman & Executive Ageing Director Report Agnes Ginges Disease of the Aorta 1 4 Bioinformatics ABOUT CENTENARY Cardiovascular Signalling Board of Governors Cellular Mechanobiology Scientific Advisory Board DNA Repair 2 Scientific Support Host Responses to TB Centenary Foundation Human Viral & Cancer Immunology Fundraising Committee Liver Cell Biology YCF Melanoma Cell Biology Community Fundraising Molecular Hepatology Origins of Cancer RESEARCH PROGRAMS Gene & Stem Cell Therapy HIGHLIGHTS & AWARDS Immune Imaging Financial Highlights 3 Liver Immunology 5 2014 Award Recipients Liver Injury and Cancer CI Lawrence Creative Prize Molecular Cardiology Structural Biology SCIENTIFIC EXCELLENCE T Cell Biology 2014 Publications Tuberculosis 6 Invited Presentations Vascular Biology Collaborations Grant Recipients Organisational Chart

Finding a CURE 5

granting bodies last year. wide, we are now known CEO of Cochlear, In addition Serena Stewart, for initiating the Centenary who will join our Board of 1 2014 the new head of our Institute Lawrence Creative Governors in early 2015. Marketing and Fundraising Prize (CILCP), which IN REVIEW team, has systematically recognises the most Many thanks to Professor EXECUTIVE DIRECTOR MATHEW VADAS AO FAHMS | CHAIRMAN THE HON MICHAEL EGAN AO put into place a strategy talented young scientists Barbara Fazekas for her and developed a team to in and promotes assistance and guidance significantly improve our their careers. during her term as There has never atmosphere, we look protecting our children fundraising capabilities Assistant Director. We also been a more back on 2014 as a and next generations from and engagement with More locally, we are thank Professor Wolfgang exciting time in hugely successful year some of the most chronic our donors (individual enthusiastic members of Weninger for his ongoing biomedical science. for Centenary in terms diseases affecting today’s donors, families, corporate Research, Sydney efforts as the new Assistant of the number and society. organisations, trusts and Partners and Sydney Director. After decades of hard work, quality of discoveries foundations, community Catalyst, the important arm increasing understanding made that will ultimately In spite of our successes, groups and many more) of the NSW Cancer Institute Congratulations also go of the cellular and fuel the biomedical 2014 has also been a and the general public, supporting all stages of to Dr Xiangjian Zheng and molecular basis of revolution and improve challenging year. The ensuring sustainable cancer research. We work Dr Mainthan Palendira diseases, and what must future therapeutics and funding climate for sources of income to with Sydney Research and on their appointment to have often seemed diagnostics for patients. medical research has support our scientists in with our long-term partners Associate Faculty. somewhat optimistic claims These discoveries span changed, and until the $20 making their next major Sydney University and RPA that these discoveries will across our chief interests of billion Medical Research breakthrough. Hospital in mounting and As mentioned, we translate into better clinical cancer, inflammation and Future Fund becomes developing plans for a welcome Serena outcomes, the payday cardiovascular disease fully operational, we need In the past, Centenary’s campus-wide organisation Stewart, our new Head of has arrived. The major and the mechanisms that to become less reliant brand (though distinctive) of research efforts for Fundraising and Marketing breakthrough this year, and drive these illnesses. on sources of funding has not reflected the optimal efficiency and – already we see an one that has culminated from the Federal and focus of our work, nor the impact. invigoration of fundraising thirty years of effort, has Our publications, State Governments. In enormous contributions we and marketing activities. been the discovery of two appearing in some of 2014, the rate of funding make to saving lives. Thus, This year we were most At the same time, we exciting ways of harnessing the most prestigious of projects by NHMRC with the great assistance of fortunate to have had farewell Jill Atherton who our body’s immune system international journals, dropped to about 15% Suanne Colley of BrandPlus Professor Axel Ullrich, previously held this position to destroy previously such as Nature, Nature (from approximately 23% a we have embarked Director of the Max Planck and thank her for her untreatable cancers of all Immunology, Nature few years before) placing on refining of our brand Institute for Biochemistry, contributions in the sorts, including melanoma. Reviews Immunology, great stress on many with a stronger and more Germany and a Member past year.

Nature Communications, scientists, including ones at concise message that of our Scientific Advisory The other truly exciting Immunity, Cell, Centenary. communicates better Board as Guest-of-Honour Finally, we would like to horizon is finally a way of Developmental Cell, with our stakeholders at our Annual General thank our Governors, treating diseases caused Ageing Cell, Journal of To face these challenges and donors. You will Meeting. He has our Faculty, Foundation, staff, by inborn genetic changes. Investigative Dermatology, efficiently and productively, see the major changes sincere thanks for making our Scientific Support Team, A new technique of PNAS and Current Biology, we will diversify our in this report and we the long trip to be with us. headed by COO Dr Nick gene-editing (one that we have put us proudly methods to source funding shall be revealing some Pearce, and our Marketing adopted for humans from amongst the very best from other national and further details in 2015, the We farewelled Professor and Fundraising team, plants) combined with in biomedical science. international bodies. Our 30th anniversary of our Susan Pond AM from our for their tireless efforts in cell-therapy will We are honoured to be, team has responded incorporation as a medical Board of Governors and supporting and promoting revolutionise the lives of surrounded by such to these challenges research institute. thank her for her valuable the Institute. Importantly, patients suffering from talented and hard working admirably, and has been contribution over the past a very special thanks to these diseases, giving them colleagues that are no successful in raising a Centenary continues to five and a half years. We our donors for their hope for a healthier life. doubt shaping the future record amount of $5.9 maintain a truly outward take this opportunity to wonderful support of In this somewhat heady of medical research, million from non-NHMRC looking stance. Australia- welcome Dr Chris Roberts, our research efforts.

Dr Susan Pond AM, FTSE Appointed Governor in 2009 Scientific Dr Pond AM, FTSE is Adjunct Professor at the , Vice President ADVISORY BOARD of the Academy of Technological 2 Sciences and Engineering, and Board Member of ANSTO, Innovation Australia Professor Sir Marc Feldman AC FAA and Biotron Ltd. Susan’s term expired in FRS FRCP FRCPath FMedSci (CHAIR) August 2014. Head, Kennedy Institute of Rheumatology, Board of Governors Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford The Hon Michael Egan AO (Chairman) Mr Alastair Davidson Professor Bruce Robinson AM Appointed Chair in 2005 Appointed Governor in 2004 Appointed Governor in 2007

Mr Egan, a former Treasurer of NSW Mr Davidson has held executive positions Professor Robinson is Dean of the Faculty (1995-2005), is Chancellor of Macquarie in the banking and financial services of Medicine, University of Sydney, and Professor Richard Flavelle CBE FRS University, Chairman of the Newcastle industry for over 30 years in the UK, US Head of the Cancer Genetic Laboratory Department of Immunobiology Coal Infrastructure Group Pty Ltd and and Australia and is a member of at the Kolling Institute. In 2003, he was Yale School of Medicine a member of the Council of NHMRC. the Institute of Chartered Accountants awarded the Daiichi Prize by the Asia Connecticut, USA During his 25-year parliamentary career in Scotland. He is an Executive of and Thyroid Association. Mr Egan held several ministerial positions. Australasian Wealth Limited, a listed asset Professor Robinson is the Founding manager, in Sydney, and a Chairman of the Hoc Mai Australia non-executive Director of Biotech Capital. Vietnam Medical Foundation.

Mr John Samaha (Deputy Chairman) Ms Elizabeth Dibbs Ms Josephine Sukkar Professor AC, FRS, FAA, MB Appointed Governor in 2003 Appointed Governor in 2013 Appointed Governor in 2011 ChB(Edin), MD(Melb) Mr Samaha leads the Australian litigation Ms Dibbs held senior legal positions Ms Sukkar is co-owner and Principal of CEO & Director of Research and contentious regulatory practice throughout her career, including General construction company Buildcorp. She is Translational Research Institute Pty Ltd of global law firm Allen & Overy. He has Counsel of PricewaterhouseCoopers prior a Director of YWCA NSW, Opera Australia represented many leading financial to her retirement. Ms Dibbs now focuses and the Sydney University Football Club institutions and corporations, as well as her energy on the not-for-profit sector. Foundation. She served as a Director executives, from a wide range of sectors, She is Pro-Chancellor of the University of of The Trust Company from 2010-2013, especially banking, wealth management, Western Sydney, a Director of United Way and is also involved with the Museum financial markets, resources, real estate, IT Australia and an active member of of Contemporary Art, Sir and telecommunications. Chief Executive Women. Foundation and Australian Rugby Union. Professor Michael Good AO BSc MBBS PhD MD DSc Institute of Glycomics Dr Teresa Anderson Professor John Horvath AO Professor Mathew Vadas AO FAHMS Griffith University, Appointed Governor in 2007 Appointed Governor in 2007 Appointed Governor in 2007 Gold Coast Campus

Dr Anderson is Chief Executive of the Professor Horvath was the Professor Vadas followed his medical Sydney Local Health District with over 30 Commonwealth Chief Medical Officer training with a PhD at the Walter and years experience in the public health from 2003 to 2009 and is a Fellow of the Eliza Hall Institute in , and system as a clinician and manager. Royal Australasian College of Physicians. postdoctoral work at Harvard. He was the Dr Anderson is a Board member for Inaugural Director of the Hanson Centre Professor Horvath recently oversaw Professor Matthias W. Hentze, MD eight organisations including the ANZAC the ’s review of for Cancer Research (now Hanson Director Research Institute, Ingham Institute, Inner Medicare Locals. He sits on the board of Institute) in Adelaide and has been West Sydney Medicare Local and Heart Crown Limited. the Executive Director of the Centenary European Molecular Biology Laboratory Research Institute. Institute since 2007. Germany

Mr Joseph Carrozzi Mr Graham Kelly Ms Deborah Willcox Appointed Governor in 2008 Appointed Governor in 2006 Appointed Governor in 2013

Mr Carrozzi is a Managing Partner at Mr Kelly is non-executive Chairman of Ms Willcox is the Director of Operations at PricewaterhouseCoopers (PwC). He is listed GDI Property Group and a Director Sydney Local Health District and General Professor Dr Axel Ullrich admitted as a Barrister at Law in NSW, of Harness Racing NSW. He has been Manager of Royal Prince Alfred Hospital. Max Planck Institute for Biochemistry a Fellow of the Institute of Chartered non-executive Chairman of various other She has held senior positions in NSW Department of Molecular Biology Accountants in Australia and a Fellow listed companies, including TAB Limited. Health and NSW Government, both as an Germany of the Tax Institute of Australia. Joseph He was formally a Partner of law firm advisor to the Deputy Premier and Minister is also Chairman of Australia’s Italian Freehills and was an Inspector of ICAC, for Health and later as Chief of Staff in Chamber of Commerce and Industry, and a Director of the Medical Research the portfolios of Planning, Housing and and Vice Chairman of the GWS Giants. and Compensation Foundation. Aboriginal Affairs. STAFF “We have developed Adam Adelpour Karen McBrien 2 Building Services Manager, the first 3D model Assistant Special Projects of the distribution Steven Allen Leah Miller Senior Technical Animal Technician Scientific Support of immune cells in Marisa Mourelle Jill Atherton Animal Facility Officer SUPPORT Fundraising & Marketing living skin. It takes Manager (until June) Danielle Moyes Animal Technician Rona Barugahare us from something Animal Facility Officer Matthew Murarotto (from March) Animal Attendant like a paper map to Gary Black Tim Neal Facility Assistant Finance Manager (until April) Google Street View.” Treena Carter Animal Technician Peter O’Donnell Finance Manager Dr Philip Tong, Dan Condon (from May) Administration Dr Nick Pearce Immune Imaging. Assistant Emma O’Flaherty Chief Operating Officer Animal Attendant Jeff Crosbie WHS and Operations Carmel Safranko Manager Animal Attendant Grants are the cornerstone increase over the Stephanie Crosbie Anna Slowiaczek of our income. This source of productivity in 2013. Donor Services Assistant HR Advisor (Fundraising Volunteer) income grew by 11% in 2014, Adrian Smith a commendable outcome Sadly, late in the year, our Felix Daniel Manager - Cytometry, Fundraising & Digital Imaging & IT given the flat funding levels at Building Assistant, Bob Marketing Coordinator (until October) Emma Squire Australian premier grantor, the Thorburn, left Centenary Animal Facility Officer Suat Dervish (until April) National Health and Medical due to ill health. Centenary’s Cytometry and Imaging Support Serena Stewart Research Council and the Executive has named our Fundraising & Marketing increasingly competitive annual Outstanding Service Willie Entona Manager (from October) Finance Officer climate for medical research. Award after him. Bob Thorburn Michael Greensmith Building Services Receptionist Assistant

Whilst expenditure on On behalf of all the Nanette Herlihen Victor Truong research activities grew by researchers and support HR Manager Animal Facility Assistant

11%, due to hard work by staff, many thanks to David Herne Heather Turner Animal Technician Animal Attendant the Science Support Team, our supporters and key Gary Ho Keri Turuwhenua administrative costs remain stakeholders, including the IT Help Desk & Support Donor Services Coordinator similar to that in 2013. Building Australian Government Owen Hoogvliet expenditure increased due to (Department of Health, ARC), Senior IT Support Chelsea Wang Assistant Accountant depreciation on the building State Government (OHMR, Daryl Hunt IT Ops Manager Helen Warwick and plant - a reflection on our Cancer Institute NSW), Director’s PA & Kristina Jahn Office Support aging home, commissioned non-government granting Imaging Support Manager in 1994. bodies, Sydney Local Health Specialist Lauren Wilson District and the general Carol Juaton Animal Attendant Animal Technician Centenary’s strength community for their ongoing Rachel Wolfenden Frank Kao Receptionist continues to be demonstrated support of our research. Cytometry Support Christine Wu by the medical research it Nicholas Keilar Animal Attendant generates, as measured by Finally, my thanks to all the Grants Manager Vince Zappala publications. Our researchers researchers and science Sarah Leonhard Animal Attendant Veterinary Manager published 103 articles in support staff for ongoing Natalie Littlejohn medical journals - a 39% hard work. Animal Technician Foundation Trustees 2 Mr Joseph Carrozzi (Chair) Mr Alastair Davidson COMMUNITY FUNDRAISING administration costs and changing advances, which MEDICAL RESEARCH HAS NEVER BEEN EASIER increasing the amount will improve the long-term The Hon Michael Egan AO Affiliated with the University of Efforts were taken to ensure available to support our health of every one of us, SydneyMr Neil and Lawrence Royal Prince Alfred our 2014 community scientists’ vital work. and for this, we are most Dr Susan HospitalPond AM, FTSE FOUNDATION fundraisers were kept grateful. regularly up-to-date on the BEQUESTS The Centenary impact their contributions Our dedicated and TRUSTS & FOUNDATIONS Institute Medical (either financial or in-kind) long-term supporters This year has seen a Research Foundation’s had made on the work shared our vision of great continuation of fundraising efforts have of Centenary’s scientists, believing that medical new and existing support research is one of the key from various trusts and seen another great especially those in the early stages of their career. components in our health foundations. Through this year, and that is thanks It’s an unfortunate reality system, ensuring future funding stream, Centenary to our most valued in research that many generations live healthier, has been able to build generous donors, researchers aren’t able longer lives. Bequest gifts its portfolio of specific supporters, advocates to follow through on their are vital to the on-going projects in the areas of and stakeholders. creative ideas, passions or work of our researchers cancer, inflammatory and curiosity because of a lack and represent a generous cardiovascular diseases. Ongoing support from our of funding; therefore, support and lasting legacy of an We would like to sincerely regular donors, members, from our active community individual’s pledge to thank all of those who have individual donors, trusts, members is vital. It is those make a difference. This generously supported foundations, bequestors, ‘seemingly crazy’ ideas continued investment in our fight against these and corporate partners, the Centenary Institute increasingly prevalent Joseph Carrozzi, Centenary’s Patrons, Professor the Hon Dame AD CVO that need funding as often has enabled a collective and Sir Nicholas Shehadie, AC OBE, and The Hon Michael Egan AO they have unexpectedly enables discoveries and life conditions. and positive impact on to celebrate as we reflect underlying mechanisms important results. This year, we the vital research our back on how Centenary’s of chronic diseases would like to express great As Winston Churchill said, “Healthy citizens are the greatest scientists undertake scientists have made major like cancer (prostate, thanks to the members of the asset any country can have”. Support from the community is a hugely powerful tool; it is what enables Centenary’s researchers everyday. This has contributions to improving breast, liver, lung, and community who helped raise to continue their vital research around chronic diseases that allowed them to advance diagnostics and treatments melanoma), genetic heart over $20,000 to encourage affect so many Australian families – now, and in the future. As the technologies and research for patients and finding conditions, liver disease, innovation and creativity in Centenary Institute continues to grow, as does our relationships with a specific focus on cures for some of the most skin allergies, tuberculosis, medical research. with our donors and stakeholders. It is these individuals and cancer, inflammation and chronic diseases affecting skin disease and ageing – groups that achieve a collective impact, providing a lifeline for today’s society. an increasingly important cardiovascular disease. Our The introduction of additional the Institute and driving awareness of why medical research focus area as the average researchers are focused fundraising avenues in 2015 is the best hope we have to improve human health through GIVING BRINGS A life expectancy is only set on patient outcomes and will allow people to give scientific excellence. As a member of the Board and Chairman finding cures to protect SENSE OF FULFILLMENT to increase over the next regular donations or utilise of the Foundation Committee, thank you future generations from Throughout the year, the decade. the system to promote and for sharing our vision of improving human the some of the most income generated through fundraise for their community health through excellence in medical chronic diseases affecting our donor appeals and We sincerely thank our events simply and easily. By research and joining us in our mission to Australia’s population today. acquisition campaigns generous donors for their simplifying the giving process discover and bring to use innovative has greatly assisted ongoing commitment to and encouraging regular therapeutics and diagnostics. Your Next year, the Centenary Centenary’s scientists to our vision of improving donations, Centenary can commitment and your loyalty are greatly valued by not only the Centenary Institute, Institute will be celebrating continue their vital research human health through count on a more reliable but by the Australian population. a milestone – its 30th year into understanding excellence in medical source of income, helping anniversary. We have much the complexities and research. us to plan ahead with less JOSEPH CARROZZI | FOUNDATION CHAIR 2 Many Thanks TO OUR LOYAL SUPPORTERS We acknowledge the generous support of all those individuals and corporations who Fundraising have contributed to our fundraising efforts throughout 2014. We thank you. In particular... COMMITTEE 2014 ANNUAL FOUNDATION DINNER SUPPORTERS TRUSTS & FOUNDATIONS Accolade Wines Live and Cookin Lizotte’s Andrew Cameron Family Foundation Mr Joseph Carrozzi (Chair) Ms Suanne Colley Mr Simon Dulhunty Mr Simon Ford Mr John Samaha Albert Jangtong (HeyAlbert.com.au) Macquarie Telecom Gray Family Trust Justice Margaret Beazley AO Ms Elizabeth Dibbs Mrs Julie Ford Mrs Tanya Jones Mr Andrew White Alex Ford Magdalena Photography K H Cheung Foundation Pty Ltd ANZ Stadium Maui Jim Litterbach Family Trust Bangarra Dance Theatre Mount Mary Vineyard, Yarra Valley Lowe Lippmann Charitable Fund Burberry Mr Black T & J Weeks Family Trust Burch Family Wines Neil Lawrence The Alexandra and Lloyd Martin Family Foundation Caroline Lawrence Nick Mount The Corella Fund Clarendon Hills Oobie Baby The R A Gale Foundation Clonakilla Wines Penfolds The Rix Foundation David Hall OAM Posh Boutique GENEROUS INDIVIDUALS Ella Baché PricewaterhouseCoopers Dr Teresa Anderson Ensemble Theatre Company Qantas Mr Graeme & Mrs Carolyn Aplin Fiona Campbell of She Rocks Racing NSW Mrs Kathy Booth First Aid For You Rockford Wines Professor Michael Boyer Flutter Lyon Rockpool Bar and Grill & Neil Perry Mr Norman Brunsdon AM Free Radical Enterprises Sony Music Mr Joseph Carrozzi Garfish Susan Lancaster Ms Liz Dibbs & Mr David Tudehope Golden Door Health Retreat Elysia Tanya and Bruce Jones The Hon Michael Egan AO Greater Western Sydney Giants Taronga Zoo Mr Jonathan Emery Henschke Wines Tennis Australia Mr David Farley Hunt Leather Theme & Variations Piano Services Mr Richard Fisher India Ford Tintilla Estate, Pokolbin Estate of the Late Warwick Jeffrey Flecknoe Janet Laurence Torbreck Barossa Valley Mr Simon & Mrs Julie Ford Julie and Simon Ford Treasury Wine Estate Mr Tarun Gupta John and Lynette Cunnington Waterford Dr Jill Hawker J H Cutler Bespoke Tailor Wendy Collins Mr William Hayward Lawrence Creative Strategy Young Centenary Foundation Mr Matthew Henderson John and Jennifer Clarke and Kristina and Andrew White Lindt Chocolate Dr Francis Hooper & Mrs Marie Therese Hooper COMMUNITY FUNDRAISERS Centenary’s Foundation Committee, THE GALA DINNER Mrs Jessica Hore IN CELEBRATION Peter ‘Wally’ Bamford Memorial Concert Dr Susan Howlett has been extremely active in its The dinner, generously hosted by Joseph Carrozzi Sarah Bellingham Mr Robert Ingham th 50th Birthday PricewaterhouseCoopers for its 6 year, Mr Bruce & Mrs Tanya Jones fundraising efforts, raising over Jessica Boyd saw 140 guests come together to enjoy Prue Struik Mr Bradley Keding $145,000 this year. 40th Birthday Carina Cutmore Mr Graham & Mrs Christine Kelly

quality wine, music, conversation and an Felix Daniel Mr Neil Lawrence Centenary’s Foundation Committee, auction full of fantastic prizes. BEQUESTS Adrian Digiacomo Mrs Christine McComb Mr James McGregor made up of a number of highly Waybrett James Avery Luke Foundation Mr Rowan Mitchell THE SOIRÉE WITH SCIENTISTS Leslie Allan Maurer Amy Marshall committed volunteers, is a great support Mr Oliver Morgan & Ms Sheridan Lee to the Fundraising and Marketing Team, The evening was generously hosted by Kevin Gregory Moston Erin Moy Mrs Patricia New helping to increase the level of income Alan Ramsay Erin Parkinson Mr Jon North Foundation Committee Members, Julie Mr Ian Norman Geoffrey Ernest Stolz Payne and Olive generated which is needed now more and Simon Ford. The Ford’s have very Mr Peter & Mrs Nora Rowe Jeremy Perrott Mrs Elizabeth Salkeld than ever due to the current funding kindly hosted this annual event since 2011, CORPORATE Shirley & Teddy Mr Norman Seckold climate. They have devoted their time providing a wonderful opportunity for the BHP Billiton Samantha Stewart Mr James Smail and resources to help continue to grow Mr Douglas Snedden general pubic to meet Centenary scientists Lauren Sullivan income through two major events; the Mr Harry Tamvakeras in person and hear more on how they are Joanna Sweeting Foundation’s Annual Gala Dinner and the Professor Mathew Vadas AO trying to save lives and improve patient Megan Taylor Mr Andrew White Soirée with Scientists. outcomes - a rare experience for many. Mr Kim Williams AM Members of the Young 2 Centenary Foundation at the 2014 Centenary Foundation Dinner Kate Adams, Lauren Sullivan and Erin Moy (YCF Chair)

YOUNG CENTENARY CHAIR: KATE ADAMS FELIX DANIEL ANNA LAWRENCE GEORGIE SKIPPER ERIN MOY SARAH BELLINGHAM CAROLINE FANNING AMY MARSHALL LAUREN SULLIVAN FOUNDATION MEMBERS CHRISTINA BOUZIOUS JEFF HOLST JEREMY PERROT THOMAS TU

CO-LAB | JULY 2014

In July, YCF got arty and produced CO-LAB, a group show curated by Georgie Pope and Jess Holburn from CHASM Gallery in response to the scientific imaging being created by Centenary scientists.

LUAU | FEBRUARY 2014 Exhibiting artists included Beastman, Anna Langdon, Summer of 2014 was Rafaella McDonald, Oliver Tanner, Dreamcatcher, marked by a sunny Will Cooke and Yiwon Park. and sold-out YCF Hawaiian fundraiser on a The pop-up exhibition was open for one night only spectacular Darlinghurst and proceeds from the sale of all works were split rooftop. evenly between the artists and the Young Centenary Foundation to fund grants for life saving research across DJs Harry Hunter, Desperate cardiovascular, cancer and inflammatory diseases. Sluts, ROOF and Mike Who got the tropical crowd YCF raised $5,650 and received a huge amount of press dancing. Food and drinks coverage from the likes of the Sydney Morning Herald, Time flowed care of Tsingtao, Out Sydney, Broadsheet, The Beast, Pagesdigital, Backyard Kopparberg, Vodka O, Opera, Eastside Radio and Concrete Playground. Tequila Blu, Splitrock & Tiro, Bulleit, Brasserie Bread and Havericks Meats.

The event raised a total of $4,103 and gained the YCF press mentions with Pedestrian, Out In Sydney, Concrete Playground, CITY2SURF | AUGUST 2014 Broadsheet, The Beast, 10 YCF runners took on the 14km dash from city to surf Pagesdigital and in August as part of the Centenary Institute’s Run For Time Out Sydney. Research team, and collectively, the YCF raised $5,260.

Meet Olive 2 Community Olive raised $1,823.25 for Centenary in the 2014 City2Surf. FUNDRAISING

Olive ran with her Mother and Aunty, in memory of her Papa, who had just two weeks earlier lost his battle with a genetic heart condition. Olive started with a fundraising goal of $700 and was supported by the generosity of her friends and family.

Thank you Olive, your Papa would be very proud!

Coming together shown their belief in the raised over $30,000 for the to save lives. contribution medical Centenary Institute Medical research has to our health Research Foundation. We have an amazing and well-being. community of people 2014 is the 10th anniversary who do wonderful things Families like the Bamford’s of Peter’s passing. His family which contribute who lost their son and and friends have not only significantly to raising brother Peter in 2004 to raised invaluable money but funds and advocating for Sudden Arrhythmia Death also enormous community medical research. Syndrome (SADS), a genetic awareness for Centenary’s heart condition most Molecular Cardiology During the past year common in young people. Program (headed by dedicated individuals, Professor Chris Semsarian) families, groups and Since 2008, the Peter and their research in the organisations have ‘Wally’ Bamford Memorial area of genetic heart committed their time and Concert has been held at conditions. Every dollar resources to supporting Peter’s ‘favourite drinking raised contributes directly Centenary. Running hole’ the Old Canberra Inn to our research. marathons, walking the on the weekend closest City2Surf, hosting open air to his birthday. Organised We extend our heartfelt movie nights and organising by family and friends and thanks and appreciation concerts are just some of with amazing support from to all our community the ways our community the local community, the fundraisers, their families, fundraisers have publicly memorial concert has now friends and colleagues.

3Programs GENE AND STEM IMMUNE IMAGING CELL THERAPY PROFESSORPROFESSORPROFESSOR PROFESSOR The Immune Imaging Program investigates how the immune JOHNJOHN RASKORASKOJOHN AOAO RASKO AO WOLFGANG WENINGER system in the skin fights infections and tumours, and how our Our Gene and Stem Cell Therapy Program is focused on HEADHEAD OFOFHEAD PROGRAMPROGRAM OF PROGRAM HEAD OF PROGRAM body’s immune responses lead to skin allergies. Eczema and better understanding regenerative medicines to develop atopic dermatitis are two common allergic conditions. Up effective treatments for cancer, heart disease and genetic to 30% of children in Australia suffer from atopic dermatitis, diseases. Regenerative medicine is the process of replacing and 2-3% of the general population suffer from psoriasis, a or regenerating human cells, tissues or organs to restore or InSaving Savinga sentence Lives Lives Saving Lives common skin disease. establish normal function. WeWe are developing developing new Our research is aimed at Our research can save newapproaches approaches to cancer to finding new therapies for lives by helping us understand UNDERSTANDING DISEASE FINDING A CURE UNDERSTANDING DISEASE FINDING A CURE cancertreatment,cancer, treatment, throughdegenerative our and how the immune system fights genetic diseases. disease and infection. throughgrowing understanding our growing of We are using high-end Our research spans from We are focused on In the laboratory, we are understanding of how imaging technologies, bench to bedside. We understanding how cancer focused on identifying the such as multi-photon have recently discovered cells work. triggers that switch cancer cells work. STAFF STAFF microscopy, to dissect in a novel immune cell type genes on and off in cancer real-time the working of the in the skin – the dermal Cancer is caused by the cells with the long-term Amy Au Lyn Moir Rona Barugahare Zufu Lu Research Officer Visiting Researcher Research Assistant Visiting Researcher immune system in the skin. group 2 innate lymphoid accumulation of mutations goal of developing new Centenary houses one of cell (ILC2). We have found STAFFSTAFFChuck Bailey Rajini Nagarajah Kim Beaumont Jorge Luis (errors) in our DNA. Cancer cancer therapies. Senior Research Officer Research Assistant Research Officer Galeano Nino Australia’s leading imaging that these cells can causing mutations activate Masters Student HeadHead of ofYue Program Program (Julie) Feng ResearchResearchTrung Viet Assistant Assistant Nguyen Maté Biro facilities to enable this cause inflammation in the oncogenes or inactivate By integrating the JohnJohn Rasko RaskoResearch Assistant NataliaNataliaResearch Pinello Pinello Assistant Research Officer Andrew Mitchell research. skin of animals. We are Research Officer tumour suppressor genes. Centenary Institute’s AssociateAssociate DadiFaculty Faculty Gao ResearchResearchHugh Assistant AssistantNursey Radjesh now studying how these Multiple DNA mutations Bioinformatics expertise JeffJeff Holst Holst PhD Student YueYue Feng HonoursFeng Student Bisoendial Mary Mouawad Visiting Researcher Research Assistant We study the pathogenesis ILC2 cells are involved lead to the development of into all of our research AssociateAssociateJane Faculty Faculty Gordon ResearchResearchNick Assistant Assistant Otte of several inflammatory skin in eczema and atopic WilliamWilliam Ritchie RitchiePhD Student RajiniRajiniMasters Nagarajah Nagarajah Student Vania Caldas Marcia Munoz cancer. areas, we have significantly Summer Research Scholar Research Officer diseases such as psoriasis dermatitis formation in increased the outcomes of SeniorSenior Research Rae-AnneResearch Hardie PhDPhD Scholar NataliaScholar Pinello OfficerOfficer Research Officer AbramAbramResearch Wassef Wassef Assistant Lois Cavanagh Peter Newman and atopic dermatitis. We humans. One tumour suppressor our research in the lab. ChuckChuck Bailey Bailey Senior Research Officer Visiting Researcher are also investigating how Jeff Holst PhDPhD Scholar ScholarCarl Power gene called CTCF is a ResearchResearchAssociate Officer Officer Faculty FionaFionaEditorial Guan Guan Research Officer Hsien Chan Hannah O’Riley we can manipulate the We have discovered DNA binding protein that Our research has AmyAmy Marshall Marshall Visiting Researcher Visiting Researcher Fiona Guan PhDPhDMichelle Scholar Scholar Simmons immune system for more using animal models that is important for normal discovered new ways to ResearchResearchPhD Officer Officer Student JaneJane Gordon PhDGordon Student Adam Cook Ben Roediger infective strategies against ‘golden staph’ selectively JustinJustin Wong Wong Postdoctoral Fellow Research Officer organisation of the target blood cancer. It has Karieshma Kabani PhDPhD Scholar AnnoraScholar Thoeng melanoma and common destroys a specific immune chromatin, found in our also identified key nutrient ResearchResearchPhD Officer Officer Student LianeLianeResearch Khoo Khoo Assistant Anne Cooray Danae Sharp KevinKevin Wang Wang Research Assistant Research Assistant skin infections, for example cell type in the skin, the chromosomes. Mutations pumps which are vital Liane Khoo PhDPhD Scholar ScholarKevin Wang those caused by ‘golden perivascular macrophage ResearchResearchPhD Officer Officer Student KerenKerenResearch Weiss Weiss Officer Gyohei Egawa Lisa Shaw and deletions of the CTCF to the growth of prostate KatherineKatherine Lau Lau Visiting Researcher Research Assistant staph’. (PVM). This results in the gene occur in many cancer cancer cells. Amy Marshall MedicalMedicalKeren Student Student Weiss EditorialEditorialResearch Research Research Officer NickNick Otte OttePhD Student Pamela Graney Sioh-Yang Tan dampening of the immune types including blood OfficerOfficer Visiting Researcher Research Officer Golden staph infections response against this CarlCarl Power PowerCynthia Metierre HonoursHonoursJustin Student Student Wong cancer. We are working Using these discoveries Research Assistant AnneAnneResearch Moran Moran Officer Nikolas Haass Szun Tay are a leading cause of dangerous pathogen. We to understand how CTCF and our knowledge of ResearchResearch Assistant Assistant Associate Faculty Research Officer CynthiaCynthia Metierre Metierre infections in the hospital are now investigating the functions in normal cells, how cancer cells work, Rohit Kumar Jain Shweta Tikoo setting and account function of PVM in human ResearchResearch Assistant Assistant Research Officer Research Officer and how changes in the we are striving towards KatherineKatherine Champ Champ for more deaths in the skin, and how we can CTCF gene lead to cancer better therapeutics for the Rain Kwan Philip Tong Research Assistant PhD Student developed world than HIV improve their response in development. treatment of cancer. or tuberculosis infections. bacterial skin infections. Jun Liang Visiting Researcher 3 LIVER INJURY LIVER IMMUNOLOGY AND CANCER

The Liver Immunology Program is studying the unique relationship The Liver Injury and Cancer Program aims to discover new liver DRDR PATRICK PATRICK BERTOLINO BERTOLINO PROFESSOR GEOFF between the liver and the immune system. Livers dampen down cancer pathways that could be targeted for improvements in HEAD OF PROGRAM McCAUGHAN immunity to such an extent that they can be transplanted without HEAD OF PROGRAM treatment and outcomes of patients with progressive liver disease. rejection in some cases. Livers may not only be tolerated, but may HEAD OF PROGRAM We also work to discover new biomarkers that could improve also prevent the rejection of other organ grafts from the same diagnosis of liver injury and cancer. donor, a process known as immune tolerance.

Saving Lives UNDERSTANDING DISEASE FINDING A CURE UNDERSTANDING DISEASE FINDING A CURE Liver cancer is a huge killer in Australia. We are Liver diseases are caused According to The Australian Our research is helping to The ultimate goal of our working to change that by by chronic inflammatory Liver Association, liver disease improve our understanding research is to improve In a sentence developing new therapies processes. They are driven now affects over six million of the liver and its impact treatments in organ OurDR research DAVID BOWEN is and treatments. by many factors including Australians and has an on immune responses, both transplantation, as well as helpingASSOCIATE to improveFACULTY wanted and unwanted. deliver effective prevention viruses, autoimmune annual cost burden of and treatment of chronic our understanding processes, genetic diseases $50.7 billion. Although the liver’s tolerance liver disease. of the liver and STAFF and toxins such as alcohol. effect leads to better Liver disease is responsible its impact on Magdalena Budzinska Amelia Lin outcomes in transplantation, Liver diseases caused by Research Assistant Summer Research Our work is devoted to for one quarter of all – Saving Lives Scholar it can be detrimental during viral hepatitis represent an immune responses, Jinbiao Chen understanding pathways at organ transplants and if Our research will help Research Officer Adriano Luongo infections such as hepatitis increasing health burden both wanted and Masters Student the cellular and molecular left untreated, results in liver improve outcomes for Yiqian Chen B, hepatitis C and malaria. to the community. Hepatitis Research Assistant Annette Maczurek levels that drive liver injury cancer - the fastest growing STAFFunwanted.people undergoing organ Research Officer These diseases can use the C (HCV) infection leads to Robert Cheng and cancer. These pathways form of cancer in Australia. transplantation, as well as PhD Student Bramilla Patkunanathan liver as a means of persisting, cirrhosis and liver cancer, Head of Program Research Assistant may then be identified as which can often lead to the third-leading cause Patrickimproving Bertolino treatments for Sumaiya Chowdhury Emilia Prakoso therapeutic targets or be The increasing prevalence of chronic infection. of cancer-related death people with liver disease. Research Assistant PhD Student Associate Faculty used to diagnose and stage all forms of liver disease, but worldwide. William D’Avigdor Devanshi Seth David Bowen PhD Student Affiliate Member liver disease and cancer. in particular fatty liver disease Our Liver Immunology Team of Faculty Alastair Duly with concurrent diabetes, is a is also providing some 200,000 Australians are Senior ResearchSTAFF Research Assistant Nick Shackel Officer Associate Faculty We initially used human huge burden. important clues to improve currently infected with HCV, Kate Bremner Margaret Gall Frederic Sierro PhD Student Nicholas Sigglekow Research Assistant liver samples to screen the success of human gene with around 20,000 being Research Officer Mark Gorrell for molecules that we up Our research spans from therapy. diagnosed each year. Research ZoeOfficer Liu Associate Faculty Thomas Tu Michael WongHonours Research Officer regulated. Since then we test tubes, to animal models, Candice Grzelak Having already shown that Our Liver Immunology Claire McGuffog Research Officer Helen Vidot have taken some of these human models and clinical ResearchTechnical Assistant Officer PhD Student the liver, like the lymph nodes, Program, which encompasses Elizabeth Hamson molecules and manipulated trials. Bharvi Maneck PhD Student Pok Fai Wong Bharvi Maneck can activate T cells (a key 20 years of original study, has Honours Student them in experimental Research Assistant James Henderson cell of the immune system) discovered key new principles Research Assistant PhD Student Grace Yan models. This has allowed Throughout 2014 our research Kate BremnerFrederic Sierro Summer Research we are now investigating governing liver immune Senior Research Officer Emily Huang Scholar us to test whether these identified key new pathways how the liver induces function. These discoveries Research Assistant TechnicalMichelle Officer Vo Christine Yee molecules actually play a and biomarkers which are PhD Student Jessica Hyman Research Assistant immune tolerance and how are helping to develop new Claire McGuffog Research Assistant role in causing liver injury. helping to develop new liver immunity can be enhanced and improved treatments for Emma Zhang Yik Chun (Michael) Wong Fiona Keane PhD Student cancer therapies. in this organ. liver disease. PhD ScholarResearch Officer Research Officer Michelle Vo Nicole Wood Aimei Lee Research Assistant PhD Student 3 MOLECULAR STRUCTURAL CARDIOLOGY BIOLOGY PROFESSORPROFESSOR ASSOCIATE PROFESSOR CHRISCHRIS SEMSARIAN SEMSARIAN MIKA JORMAKKA The Structural Biology Program looks at a detailed 3D structural Molecular Cardiology is the study of genetic heart disorders. Our HEAD HEAD OF OFPROGRAM PROGRAM HEAD OF PROGRAM major goal is to reduce human disease through the integration of and functional understanding of the proteins involved in human basic science research and clinical cardiology. iron distribution. By determining the structures of proteins involved in these processes, we aim to be able to provide a scaffold for the development of drugs that can effectively ‘tune’ their function and UNDERSTANDING DISEASE FINDING A CURE InSaving a sentence Lives thus provide new treatments for patients, in particular patients with Our researchmajor goal saves is Anemia of Chronic Disease (ACD). Our research is focused on Around 30,000 Australians tolivesSaving reduce by helping humanLives to Saving Lives understanding the clinical die every year from sudden diseaseinitiateWe are working treatment through to initiate Our research provides UNDERSTANDING DISEASE FINDING A CURE and genetic basis of inherited cardiac death. Around four treatment strategies ‘blueprints’ of drug targets heart disease. We use a range young Australians, under the thestrategies integration to prevent to prevent serious involved in anemia and Iron is an essential element, Studies have shown that of approaches including age of 35, die every week from serious complications, ofcomplications, basic science including cancer - a critical platform which is acquired from our 30-80% of cancer patients, human gene discovery studies, sudden cardiac death. researchincludingheart failure heartand and failure for drug development. diet and distributed in our 25-50% of chronic kidney basic cellular systems, animal body by a set of specific disease patients, and between and suddensudden death. death. models of human disease, We know that there are around clinical cardiology. membrane proteins. In 20-90% of acute and chronic and population-based 40 cardiovascular conditions humans the acquisition infections are associated with psychosocial and public caused by underlying genetic and distribution of iron is anemia. In these patients, ACD health studies. faults. We all have around STAFF required for a range of vital is correlated with heart failure, 22,000 genes, but a fault in cellular processes, such as poor prognosis and lower Head of ProgramSTAFFResearchResearch Our research involves just one can result in a life Chris Semsarian Assistant STAFF generation of red blood cells. quality of life. state-of-the-art approaches threatening heart condition. JoannaJoanna SweetingSweeting ClinicRichard Co-ordinator Bagnall Sophie McLeod Chandrika Deshpande including whole exome LauraLauraSenior YeatesYeates Research PhDPhDHonours ScholarScholar Student Research Officer Errors in the proteins involved Perioperative anemia has Officer JipinJipin DasDas sequencing, mRNA and We can already see our Clinical Research KizhakkepattKizhakkepattCaroline Medi Amy Guilfoyle in iron distribution can also been correlated with microRNA profiling, and research directly reducing CoordinatorCharlotte Burns Research Officer PhD Student cause a range of disease increased morbidity, mortality, LauraLauraResearch MolloyMolloy Assistant PhDPhD ScholarScholar RNASeq. Most importantly, we sudden cardiac death in our RatnasariRatnasariLaura Molloy PadangPadang Aaron McGrath states, such as cancer and and length of hospital stay. ClinicalMaria Research Clinical Research Research Officer have the key clinical resources, communities. Our new gene CoordinatorConstantinou PhDPhDCo-ordinator ScholarScholar anemia (reduced levels of including well phenotyped discoveries are being used CatherineMasters Student Spinks RhianRhian ShephardShephard Ratnasari Padang red blood cells). In long-term A systematic review of 60 individual patients and families, as improved diagnostic tools, RegistryRegistryCarina Cutmore PhDPhDPhD StudentStudent Student hospitalised patients, such as studies found the relative Co-ordinatorResearch Assistant BelindaBelinda GrayGray which form the basis of all our we are rolling out implantable TanyaTanya SarinaSarina Tanya Sarina cancer patients or patients risk of death in patients with genetic studies. cardioverter defibrillator Jipin Das RegistryMasters Coordinator student with chronic inflammation or cancer increased by 65% in ResearchResearchKizhakkepatt OfficerOfficer Maria Constantinou therapy and we are actively CarolinePhD Student Medi Catherine Spinks infection, there is commonly the presence of anemia. MastersClinical studentResearch To get to this point, we have involved in improving public ResearchResearchBelinda Officer OfficerGray ReneeReneeCo-ordinator JohnsonJohnson an imbalance in the iron developed cohorts and health measures. JodieJodiePhD InglesIngles Student distribution, leading to Every day our research comes HonoursJoanna Sweetingstudent national registries of patients ResearchResearchJodie Ingles OfficerOfficer CarinaPhD CutmoreStudent Anemia of Chronic Disease. one step closer to finding a LienLienResearch LamLam Officer and families with inherited Our research is about saving MedicalTatiana Tsoutsman Student cure. heart diseases. We also lives, sudden death prevention, ResearchResearchRenee Johnson OfficerOfficer JenniferJenniferResearch KozlovskiKozlovski Officer By understanding membrane RichardRichardMasters BagnallBagnall Student utilise the latest in genetic and improved diagnosis and VisitingVisitingLaura Yeates protein anatomy, structure We are progressing our aim technology in order to form management of patients and ResearchResearchLien Lam OfficerOfficer GeneticsResearcherResearcher Counsellor TatianaTatianaResearch TsoutsmanTsoutsman Officer VanessaVanessa ConnellConnell and function, we hope to for the ‘perfect’ drug to treat the basis of our novel gene families with genetic heart facilitate a structure-based ACD, with the development of ResearchResearch AssistantAssistant discovery studies. diseases. Charlotte Burns drug discovery. pharmaceutical compounds.

3 T CELL BIOLOGY TUBERCULOSIS

We are studying the diseases of the western lifestyle, with our Our approach to tackling Tuberculosis (TB) is through a range of PROFESSORPROFESSOR BARBARA BARBARA PROFESSOR main focus on allergy (asthma, eczema), autoimmune disease measures – developing new vaccines and drugs, improving our FAZEKASFAZEKAS DE DE ST ST GROTH GROTH WARWICK BRITTON (rheumatoid arthritis, psoriasis, systemic lupus erythematosis) and understanding of TB immunology, discovering new biomarkers and HEADHEAD OF OF PROGRAM PROGRAM HEAD OF PROGRAM inflammatory bowel disease (Crohn’s disease, ulcerative colitis). All contributing to public policy and practice. As a part of the Centre of these conditions share a common factor – subtle abnormalities in Research Excellence in Tuberculosis Control we have the platform to the regulatory T cells that are the controllers of the immune system. . translate new discoveries into more effective tools to control TB.

UNDERSTANDING DISEASE FINDING A CURE InSavingSaving a sentence Lives Lives Saving Lives UNDERSTANDING DISEASE FINDING A CURE OurWe researchstudy inflammation We are developing We have been studying the The impact of our research is focuses- the key on driving T cells force new ways to fight TB and TB is the major cause of We are developing vaccines basic interactions that control far reaching, from cancer to behind most chronic stop it from spreading. death from a bacterial for delivery to the lung to anddiseases the vital and cancer. role immune responses. inflammatory diseases. pathogen in adults; in boost immunity against they play in the 2013 alone there were 1.5 TB. We are also developing Our research has defined new Immune dysregulation and human immune million deaths from TB and subunit vaccines that contain ways in which the immune inflammation is the driving system. nine million new TB cases proteins to stimulate protective system learns to tolerate factor behind 60% of deaths STAFF STAFF worldwide. In addition it immunity against different allergens and to control worldwide. Suzanne Asad Ellis Armitage Lalita Narayan PhD Student remains an important cause stages of the TB infection. autoimmune disease. STAFF Talented Student Administration Program Officer More specifically, autoimmune Luke Beebe of childhood illness and Head of ProgramResearch Assistant Simone Barry Tomoki Ohashi mortality in high burden Around two million people The T Cell Biology Program has diseases affect 15-20% of Barbara Fazekas PhD Student Honours Student developed sophisticated new Australians at some stage de St. Groth Holly Bolton countries, with 80,000 deaths have latent TB infection, with Research Officer Nayan Bhattacharya Mainthan Palendira methods for analysing the in their lives, allergies up to Senior Research Honours Student Research Officer in HIV-negative children in around 5% risk of developing Officer Michelle Brownlee immune cells in blood. 50% and other inflammatory Elena Shklovskaya Claudio Counoupas Angel Pang 2013. active TB during their lifetime. Microinjectionist PhD Student Research Assistant diseases close to 100%. As such, we are working to Research OfficerThomas Guy Jarem Edwards Thaigarajan We use these new methods Holly Bolton PhD Student Summer Research Parumasivum Of importance to Australia, TB discover new biomarkers to Scholar PhD Student to define ‘immune signatures’ In cancer, we are currently Research OfficerAlex Hodkinson is an enormous and rapidly distinguish those with active Michael KuligowskiVisiting Researcher Magda Ellis Roman Pillay that predict the chance profiling the immune system Research Officer Research Assistant growing problem in our TB. We are also conducting Research Assistant of developing allergy, in cancer patients in order Michael Kuligowski Samantha Ellis Rachel Pinto Cindy Zhu region, which contains 58% a genome wide association autoimmunity, or responding to predict who will respond Research Officer PhD Student Research Officer of global TB cases and 56% study to identify genetic to cancer therapies that best to therapy. We are Research AssistantLoretta Lee Carl Feng Kelly Prendergast Michelle BrownleePhD Student Visiting Researcher Research Officer of multi-drug resistant TB. variants that contribute to involve the immune system. also studying the immune Research AssistantYik Wen Loh Manuela Florido Bernadette Saunders increased susceptibility to TB. Research Officer Associate Faculty response to cancer in animal Yu Qing Rain KwanPhD Student As a result, our STOP-TB Nathan Hare Gabriella Scandurra T Cell Biology studies are models. Research Assistant Lauren McKnight Research Officer Executive Officer strategy calls for intensified The major threat to TB control carried out using our Luke Beebe PhD Student Leon Lin Sebastian Stifter research into more effective is the emergence of drug world-first 10-laser flow In inflammation, we are PhD ScholarElena Shklovskaya Research Officer Research Officer cytometers. Our CyTOF studying how the immune AlexandraSenior Terry Research Officer tools to control TB, including resistant strains of the infection. Elena Martinez Jamie Triccas Research Officer Affiliate Faculty machine, commissioned in system is controlled at the Alexandra Terry completely new approaches For the past five years we have PhD Student Thomas Mather Anneliese Tyne to TB vaccines, TB drugs and also been working towards the late 2014, is the first in fundamental level of Honours Student PhD Student Australia, and will dramatically pro-inflammatory and Cindy Zhu tools for the diagnosis of development of new drugs Research Assistant Heni Muflihah Kelly Veale increase the speed and anti-inflammatory interactions PhD Student PhD Student active TB and biomarkers to that are effective against accuracy of our clinical between dendritic cells and Gayathri Nagalingam Emma Watson monitor the response these increasingly prevalent Research Assistant Honours Student research. CD4 T cells. to therapy. drug resistant strains. Beatrice Nagaria Heng Giap Woon Masters Student Research Assistant Meet our Scientists 3 James Henderson PhD Student – Liver Injury & Cancer “Centenary has state-of-the-art flow cytometry VASCULAR BIOLOGY and imaging equipment, as well as an impressive animal facility. Along with skilled Blood vessels supply every organ in our body with blood and technicians who go out of their way to train PROFESSOR nutrients. They are also central to most diseases, especially the and provide as much assistance as possible. JENNIFER GAMBLE chronic inflammatory diseases. Our Vascular Biology Program Centenary provides its students with access to investigates the two main cells that form blood vessels – endothelial HEAD OF PROGRAM a variety of cutting edge techniques cells and smooth muscle cells. and equipment.”

UNDERSTANDING DISEASE FINDING A CURE Saving Lives Our vascular biology research Using our understanding We have developed a focuses largely on diseases of how the vessel controls world-first drug which of the aorta and diseases endothelial cell integrity, is able to stop vascular involving leaky blood vessels, we have recently identified leak and improve the including age-related macular microRNAs (small junk-like outcomes of disease. degeneration, peripheral DNA) that also play a critical vascular disease, stroke and role in changing cell junctions. solid tumour growth. These microRNAs are altered in disease and are good Vascular leak is a hallmark of targets for the development of chronic inflammatory diseases, therapeutic drugs. as well as the new blood vessels formed in cancer. We have developed a STAFF Thus, an understanding first-in-class drug that is able Garry Chang Renjing Liu of how vessels become to inhibit vascular leak and PhD Student Research Officer leaky crosses all aspects of improve the outcomes of Paul Coleman Michael Lovelace cancer, inflammation and disease, as tested in Research Assistant Research Officer

cardiovascular disease. It is pre-clinical models of Ann Formaz-Preston Natalie Patterson through this understanding peripheral ischaemia, tumour Research Assistant Research Assistant

that we are able to develop growth and eye disease. Alex Huang Elizabeth Powter drugs that may inhibit or limit PhD Student Research Assistant blood vessel leakiness. There is an urgent need for Julie Hunter Ka Ka Ting Research Assistant Research Officer drugs that specifically target Lutfun Khan Jason Wright Through our research, we have vascular leak, as there are Technical Officer Masters Student identified a molecule that is a none on the market against Angelina Lay Yang Zhao ‘guardian of our arteries’ and this aspect of disease. The Senior Research Officer PhD Student

protects us from the hardening development of an effective Jia Li Peter Zhou of arteries, or atherosclerosis, drug against vascular leak will PhD Student Visiting Researcher the basis of heart attacks and have major impact on human strokes. We have also identified health for a broad spectrum factors that can induce of diseases, including stroke, vascular leak, as well as factors cancer, cardiovascular disease that can inhibit vascular leak. and eye disease. 4 Labs & Groups AGEING CARDIOVASCULAR SIGNALLING

Is ageing a disease? It is clear that chronological, Cardiovascular Signaling studies how blood vessels and the time-dependent ageing is unstoppable. However, it is also heart form and maintain their function at a molecular and the fact that the rate of ageing is partly controlled under cellular level. The development and function of the heart and genetic mechanisms, and can be manipulated and delayed. blood vessels is a precisely regulated process. This process is The most ambitious goal of our work is to develop a cure essential for the normal function of every organ system. for ageing similar to the treatment for diseases. Our focus is finding a means of ensuring healthy ageing. Understanding how blood vessels form and maintain has DR MASA KATO DR XIANGJIAN ZHENG important implications in many human disease states, such We are working to uncover novel genetic factors and GROUP HEAD ASSOCIATE FACULTY as congenital vascular diseases, stroke, cancer, wound pathways that have a crucial role in lifespan determination in healing, diabetic complications, coronary artery diseases order to answer the key question of “what allows for longevity?” and vascular dementia.

AGNES GINGES LAB FOR CELLULAR DISEASES OF THE AORTA MECHANOBIOLOGY

The main goal of the Aorta Lab is to identify novel pathways Cellular Mechanobiology is spearheading the use of and regulators involved in cardiovascular disease, with a complex in vitro and in vivo models for studying the specific focus on epigenetic regulation in cellular plasticity. cell-intrinsic cytoskeletal cues and dynamics that govern the invasive migration of tumour cells, the tissue scanning Cardiovascular disease is a major cause of morbidity and of T Cells and their cytotoxic interaction with tumour cells. DR MATÉ BIRO mortality worldwide. The Aorta Lab is focused on identifying DR RENJING LIU key biomarkers, cellular pathways and understanding the GROUP HEAD GROUP HEAD We are also developing image analysis platforms capable complexity of human disease using cellular reprogramming. of automatically detecting and analysing the kinetics of actomyosin, cell movement and protrusions.

BIOINFORMATICS DNA REPAIR

Cancer, dementia and cardiovascular disease are all serious The DNA Repair Laboratory studies antibody mutation in health problems that are heavily reliant on supercomputers activated B cells, which is initiated by the DNA editing and complex equations to discover better treatment and enzyme “AID”. B cells mutate their antibody genes at diagnostic solutions. At Centenary, Bioinformatics gives us the extremely high rates during infections, to rapidly optimise ability to gather data in greater volumes and process it at a the ability of the antibodies they make to neutralise the much faster rate. infecting pathogen. “Off-target” mutation of oncogenes by AID underlies most adult B cell cancers. In the next decade, we believe that patient diagnosis for DR WILLIAM RITCHIE DR CHRIS JOLLY diseases, such as cancer or dementia, will be performed by ASSOCIATE FACULTY ASSOCIATE FACULTY We seek to understand why AID-induced DNA damage computer-assisted genomics tests. This type of diagnosis is leads to mutation, when similar DNA damage is generally already undertaken overseas and Australia is not far behind. repaired faithfully.

4 Labs & Groups HOST RESPONSES TO TB MELANOMA CELL BIOLOGY

The Host Responses to TB Group is focused on understanding Melanoma is the deadliest form of skin cancer, and Australia the development and expression of protective immunity to has the highest incidence in the world, with 11,569 people Tuberculosis (TB). This includes the dissecting diagnosed in 2011. Roughly 1,500 people in Australia will die macrophage-mediated immunity to TB infection, in particular from melanoma each year. the role of microRNA, microparticles and TNF family members in modulating immunity and inflammation. The Melanoma Cell Biology group is focused on investigating the molecular mechanisms regulating melanoma progression, DR BERNADETTE DR KIM BEAUMONT We have been working to examine miRNA expression during particularly the role of protein trafficking in melanoma growth SAUNDERS TB infection and the biomarker potential of miRNA to aid GROUP HEAD and metastasis. We specialise in 3D cell culture models, live ASSOCIATE FACULTY diagnosis of active TB and monitor response to therapy. imaging, confocal and multi-photon microscopy.

HUMAN VIRAL & CANCER MOLECULAR HEPATOLOGY

IMMUNOLOGY The Molecular Hepatology team is focused on understanding Epstein Barr virus (EBV) is a ubiquitous herpes virus that is the roles played by a key enzyme family in chronic liver linked to a range of non-malignant and malignant diseases. diseases. We have clear indications from following successful EBV infects more than 90% of the population worldwide, the targeting for type 2 diabetes therapy that related approaches great majority of whom recover with no long-term clinical may also combat fatty liver diseases. side effects, but in some cases it can cause glandular fever. We are working to understanding what makes chronic liver Our laboratory is interested in understanding how the human DR MAINTHAN ASSOCIATE PROFESSOR diseases wax and wane. Chronic liver disease often causes immune system normally controls EBV, and to what extent PALENDIRA MARK GORRELL inflammation, high blood pressure and cancer. aberrant controls contribute to disease pathogenesis. ASSOCIATE FACULTY ASSOCIATE FACULTY

LIVER CELL BIOLOGY ORIGINS OF CANCER

The Liver Cell Biology group focuses on understanding the The Origins of Cancer Laboratory seeks to understand how development of progressive liver fibrosis and liver cancer. cancer cells obtain their nutrients, and thereby uncover new Our research has discovered unique markers of both liver mechanisms that can be used to stop cancer cells from cancer risk and prognosis. We are working to develop growing (in essence “starving” the cancer cells). a novel technique, “liquid biopsies”, that will avoid the need for invasive tissue sampling. We have found that this Our research has shown that there are a number of key technique can be used on patients at the time of surgery nutrient pumps (LAT1, LAT3 and ASCT2) that are increased in ASSOCIATE PROFESSOR ASSOCIATE PROFESSOR to predict outcomes from a range operations, including melanoma, prostate and breast cancer. These pumps facilitate NICK SHACKEL JEFF HOLST liver transplantation. This group is led by Associate Professor the increased supply of nutrients required for cancer cells Nick Shackel, a liver transplant clinician at RPA Hospital who ASSOCIATE FACULTY ASSOCIATE FACULTY to grow. Our research has made significant strides towards ensures that the research is focused on translating key findings understanding the relationship between cancer and nutrition into clinical practice. in breast cancer, prostate cancer and melanoma. 5

FINANCIAL HIGHLIGHTS 2014 AWARDS

INCOME 2014 2013 MATÉ BIRO 1st Prize presentation award, RESEARCH INCOME in '000 in '000 Cure Cancer Australia Research Symposium, Melanoma Institute Australia, March 2014 FEDERAL - NHMRC + ARC 7094 7 386 WARWICK BRITTON Officer of the Order of Australia for distinguished service to medical research as an NSW GOVERNMENT 2543 1 140 academic and immunologist, to humanitarian and public health improvements for the people of Nepal and to the community. OTHER RESEARCH GRANTS 5621 5 169 MAGDELENA BUDZINSKA ECR PhD Scholarships, 2015 TOTAL RESEARCH INCOME 15 258 13 695 MAGDELENA BUDZINSKA First Author on top-scoring abstract, International Liver Cancer Association 8th Annual Conference, FUNDRAISING Kyoto, Japan, September 2014 CHARLOTTE BURNS DONATIONS, EVENTS + OTHER 814 896 The Human Genetics Society of Australasia (HGSA) NSW branch 2014 Student Prize CHARLOTTE BURNS BEQUESTS 52 25 The Australian Society of Genetic Counsellors (ASGC) Scientific Meeting Student Prize 2014 TOTAL FUNDRAISING 866 921 BARBARA FAZEKAS DE ST GROTH Nomination as the Burnet Orator - Highest honour of the Australasian Society for Immunology COMMERCIAL 0 0 NICK KEILAR Academy Global Scholarship for Emerging Leaders Program OTHER 3544 4 623 HENI MUFLIHAH eBioscience Poster Prize - 44th Australasia Society of Immunology (ASI) Annual Scientific Meeting, TOTAL INCOME 19 668 19 239 Wollongong, December 2014 CARLO PULITANO Distinguished Talent Visa for Research/Academia - Australian Government EXPENDITURE CARLO PULITANO Presidents Prize - Transplantation Society Australia and New Zealand (TSANZ) RESEARCH ACTIVITIES 17133 15 376 CARLO PULITANO Young Investigators Award - International Liver Transplantation Society (ILTS) FUNDRAISING 310 875 BEN ROEDIGER Associate Investigator, F&E Bauer Foundation Scholarship, ADMINISTRATION 2431 2 495 Australasian College of Dermatologist ANNA SLOWIACZEK BUILDING OPERATIONS 2465 1 613 Academy Global Scholarship for Emerging Leaders Program PHILIP TONG President’s Medal for the Highest mark in the 2014 Pharmacology Examinations for the TOTAL EXPENDITURE 22 339 20 359 Australasian College of Dermatologists THOMAS TU Senior author on top-scoring abstract - International Liver Cancer Association 8th Annual Conference 2014 HUI (EMMA) ZHANG ASBMB COMBIO Awards for Best Poster YANG ZHAO Poster Award Winner, Inaugural EMBL Australia PhD Symposium, December, 2014 YANG ZHAO Runner-up Student Poster Prize, “State of the Heart” Australia Vascular Biology Society, November 2014 5 Centenary Institute Meet the LAWRENCE CREATIVE PRIZE CILCP FINALISTS 2014 FINALIST | DR LUCY PALMER The Centenary Institute Lawrence Creative Prize (CILCP) is an exciting initiative that Florey Institute of Neuroscience and Mental Health in Melbourne promotes medical research in Australia. Dr Lucy Palmer wants to know how brain cells in mammals It is committed to encouraging a process and integrate the signals they receive from the domestic culture of scientific excellence sensory environment and how this information impacts by supporting our most promising behaviour. young scientists. Lucy obtained two degrees, a Bachelor of Science and The CILCP recognises bold young Bachelor of Arts, from the in 2001 researchers who are taking the risks to during which time she also studied abroad at the University ask the big questions of today – those of California, Santa Barbara (2000). She then obtained her questions that have most people saying Master of Science at the University of Minnesota, USA before returning to Australia to pursue a PhD, which she obtained in Neil Lawrence awarding the 2014 Winner A/Prof Geoff Faulkner “but that’s impossible”. 2008 from the ANU.

The results of Lucy’s investigations are far reaching and 2014 WINNER demonstrate the sort of adaptive changes that might occur ASSOCIATE PROFESSOR GEOFF FAULKNER in diseases that lead to disruptions in sensory perception Mater Research Institute such as stroke, traumatic brain injury, epilepsy, schizophrenia and alcoholism. A/Prof Geoff Faulkner is one of Australia’s most creative young medical researchers with his research focusing on 2014 FINALIST | DR NICOLAS PLACHTA how a common, short piece of DNA affects the operation Australian Regenerative Medicine Institute and of the brain. EMBL Australia at

Geoff thinks the differences in the way each human brain Dr Nicolas Plachta wants to develop better and simpler ways of determining the health of the embryos to be implanted in functions could be determined by a segment of mobile DNA, IVF. He does so by learning more about the very early stages which has the capacity to insert itself into the genome of of embryonic life. individual brain cells. Nicolas was born in Argentina, and studied biology at the His work may have consequences for how memories form, for universities of Buenos Aires and Tel Aviv in Israel. During this brain disorders such as schizophrenia, and even spills over into time he published his first lead author paper. diseases such as haemophilia, muscular dystrophy and some He then completed a PhD in stem cell research and forms of cancer. neuroscience at the University of Basel and the Friedrich Miescher Institute in Switzerland, working under former Max Geoff’s work has been noted internationally and groups Planck Institute Director Yves-Alain Barde. worldwide are beginning to use his techniques to check the mobile DNA’s impact on diseases elsewhere in the body. In Nicolas is convinced there is plenty more to discover about addition the US National Institutes of Health has established a what happens at the early embryo stage, and what makes a special fund to finance research into DNA mosaicism in neurons. healthy embryo. 6 Scientific Excellence 2014 PUBLICATIONS

Abtin A*, Jain R*, Mitchell A*, Roediger Bowen DG and Bertolino P. (2014). Chinnaratha MA, Chelvaratnam U, Fox GJ, Marks GB, Britton WJ (2014) Guilfoyle AP, Deshpande CN, Schenk Ingles J, Semsarian C. Conveying a B, Brzoska A, Tikoo S, Cheng Q, Ng LG, Immune response to the Hepatitis C Stuart KA, Strasser SI, McCaughan Current transmission prevention G, Maher MJ, Jormakka M. Exploring probabilistic genetic test result to Cavanagh LL, von Andrian UH, Hickey virus. Book chapter in Encyclopedia of GW, Gow P, Adams LA, Wigg AJ; methods: reducing disease spread from the correlation between the sequence families with an inherited heart disease. MJ, Firth N, Weninger W. Perivascular Medical Immunology - Autoimmune Australia and New Zealand Liver infected individuals, In: Clinical Insights: composition of the nucleotide Heart Rhythm, 2014; 11(6):1073-8 macrophages mediate neutophil diseases (Springer), Diamond and Transplant Clinical Study Group, Liver Tuberculosis Prevention. Zellweger JP binding G5 loop of the FeoB GTPase IF: 5.045 recruitment during bacterial skin Davidson Editors. Editors in chief: transplantation outcomes for Australian (Ed). Future Medicine, , UK. 53-75 domain (NFeoB) and intrinsic GDP infection. Nature Immunology, 2014 Jan; MacKay and Rose, 476-486 Aboriginal and Torres Strait Islanders, release rate. Biosci Rep, 2014; 34(6) Ingles J, Semsarian C. The value 15(1):45-53 Liver Transpl., 2014 Jul; 20(7): 798-806 Fox GJ, Sy DN, Nhung NV, Yu B, Ellis IF: 2.853 of cardiac genetic testing. Trends *equal contribution Brunklaus A, Ellis R, Reavey E, Semsarian MK, Hung NV, Cuong NK, Lien LT, Cardiovasc Med 2014, 24(6) 217-224 IF: 26.199 C, & Zuberi S. Genotype phenotype Clancy, J. Patel, H. Hussein, S. Tonge, Marks GB, Saunders BM, Britton WJ. Haass NK*, Beaumont KA, Hill DS, IF: 2.074 associations across the voltage- P. Cloonan, N. Corso, A. Li, M. Lee, DS. Polymorphisms of SP110 Are Associated Anfosso A, Mrass P, Munoz M, Kinjyo Bagnall RD, Das K J, Duflou J, Semsarian gated sodium channel family. J Med Shin, JY. Wong, J. Bailey, C. Benevento, with both Pulmonary and Extra- I, Weninger W. Real-time cell cycle Keane, FM, Yao, T-W, Seelk, S, Gall, MG, C. Exome analysis based molecular Genetics, 2014; 51(10): 650-658 M. Munoz, J. Chuah, A. Wood, D. Pulmonary Tuberculosis among the imaging during melanoma growth, Chowdhury, S, Poplawski, SE, Lai, JH, Li, autoposy in cases of Sudden IF : 5.636 Rasko, J. Heck, A. Grimmond, S. Vietnamese. PLoS One, 2014; 9(7) invasion and drug response. Pigment Y, Wu, W, Farrell, P, Vieira de Ribeiro, AJ, Unexplained Death in the young. Heart Rogers, I. Seo, JS. Wells, C. Puri, M. IF: 3.534 Cell Melanoma Res, 2014 27(5): Osborne, B, Yu, DMT, Seth, D, Rahman, Rhythm, 2014 April; 11(4):655-62 Burns C, Semsarian C, Ingles J. Access, Nagy, A. Preiss, T. Small RNA changes 764-776 (*corresponding author) K, Haber, P, Topaloglu, AK, Wang, C, IF: 5.045 uptake and communication of genetic en route to distinct cellular states Gray B, McGuire M, Semsarian C, Medi IF: 5.839 Thomson, S, Hennessy, A, Prins, J, Twigg, test results in Australian families with of induced pluripotency Nature C. Late positive flecainide challenge SM, McLennan, SV, McCaughan, Bagnall R, Crompton D, Cutmore long QT syndrome (LQTS). Heart, Lung Communications, 2014 Dec; 5(5522) test for brugada syndrome. Heart Haass NK, Schumacher U. GW, Bachovchin, WW, Gorrell, MD. C, Regan B, Berkovic S, Scheffer I, and Circulation, 2014; 23 (Suppl 2): e7 IF: 10.742 Rhythm, 2014 May;11(5):898-900 Melanoma never dies. Experimental Quantitation of fibroblast activation Semsarian C. Genetic Analysis of IF: 5.045 Dermatology, 2014 23(7): 471-472 protein (FAP)-specific protease activity in PHOX2B in Sudden Unexplained Death Calabro SR*, Maczurek AE*, Morgan Cochran BJ, Bisoendial RJ, Hou IF: 4.115 mouse, baboon and human fluids and in Epilepsy (SUDEP) cases. Neurology, AJ, Tu T, Wen VW, Yee C, Mridha A, Lee M, LM, Glaros EN, Rossy J, Thomas SR, Gray B, Semsarian C, Sy organs. FEBS open bio, 2014; 4: 43-54 2014 September; 83(11): 1018-1021 D’Avigdor W, Locarnini SA, McCaughan Barter PJ, Rye KA. Apolipoprotein RW. Brugada Syndrome: A Hamson EJ, Keane FM, Tholen S, IF: 3.986 IF: 8.303 GW, Warner FJ, McLennan SV, Shackel A-I Increases Insulin Secretion and heterogeneous disease with a Schilling O, Gorrell MD. Understanding NA. Hepatocyte produced matrix Production From Pancreatic beta- common ECG Phenotype?. Journal fibroblast activation (FAP): substrates, Kitson MT, George J, Dore GJ, Leung R, Bagnall R, Ingles J, Semsarian C. Illumina metalloproteinases are regulated Cells via a G-Protein-cAMP-PKA- Cardiovascular Electrophysiology, activities, expression and targeting for Button P, McCaughan GW, Grawford DH, TruSight Cardiomyopathy Sequencing by CD147 in liver fibrogenesis. FoxO1-Dependent Mechanism. 2014 Apr;25(4):450-6. review cancer therapy. Proteomics Clinical Siebert W, Weltman MD, Cheng WS, Roberts Panel: Application to hypertrophic PLoS One, 2014; 9(7): e90571 Arteriosclerosis Thrombosis And Applications, 2014; 8(6):454-63 SK, Interleukin-28B rs12979860 C allele: cardiomyopathy. Heart, Lung & *equal first authors Vascular Biology, 2014; 34(10):2261-7 Gray B, Spies J, Ng MK. Severe IF:2.925 Protective against advanced fibrosis in Circulation, 2014; 23(suppl 2): e5 IF: 3.534 IF: 5.533 hypertensive encephalopathy chronic hepatitis C genotype 1 infection, J following percutaneous balloon Hancock DG, Shklovskaya E, Guy TV, Gastroenterol Hepatol. 2014;29(7):1458-62 Beard MR, Ffrench R, Gowans EJ, Helbig Chan JGY, Duke CC, Ong HX, Chan Dai L, Qi Y, Chen J, Koaczorowski D, Di aortic valvuloplasty for aortic Falsafi R, Fjell CD, Ritchie W, Hancock KJ, Eyre NM, Douglas MMW, Grebely JCY, Tyne AS, Chan HK, Britton WJ, Young W, Xia P. Sphingosine kinase (SphK) stenosis. International Journal of REW, de St Groth BF. A Systems Klein A, Hambley TW, Bierbach U, Holst J, Ahlenstiel G, Locarnini S, George PM, Traini D. A Novel Inhalable Form of 1 and SphK2 play equivalent roles Cardiology, 2014 Feb15;171(3):e63-4 Biology Approach to the Analysis J. Novel Amidinediaminetricarboxylato J, Shackel NA, White PA, Thompson Rifapentine. Journal of Pharmaceutical in mediating insulin’s mitogenic IF: 5.509 of Subset-Specific Responses to Platinum(IV)-Anthraquinone AJ, Drummer HE. A Summary of the Sciences, 2014; 103(5): 1411-1421 action. Molecular Endocrinology, Lipopolysaccharide in Dendritic Cells. Complexes for Targeting Tumours. 20th International Symposium on IF: 3.007 2014 Feb; 28(2):197-207 Grzelak CA, Martelotto LG, Sigglekow PLoS One, 2014; 9 (6): e100613 Journal of Biological Inorganic Hepatitis C Virus and Related Viruses. IF: 4.746 ND, Patkunanathan B, Ajami K, Calabro IF: 3.534 Chemistry, 2014 Mar;19(Sup 1):S665 Gastroenterology, 2014; 147(1): e1-E4 Chan JGY, Tyne AS, Pang A, Chan H-K, SR, Dwyer BJ, Tirnitz-Parker JEE, Neil IF: 3.353 IF: 13.926 Young PM, Britton WJ, Duke C, Traini D. Das J, Ingles J, Bagnall R, Semsarian Watkins D, Warner FJ, Shackel NA, Hill DS, Lovat PE, Haass NK*. Induction A rifapentine-containing inhaled triple C. Determining patheogenicity of McCaughan GW. The Intrahepatic of endoplasmic reticulum stress as Kozlovski J, Ingles J, Connell V, Hunt L, Beaumont KA, Mohana-Kumaran N, antibiotic formulation for rapid treatment genetic variants in hypertrophic Signalling Niche of Hedgehog is a strategy for melanoma therapy: McGaughran J, Turner C, Davis A, Sy R, Haass NK. Modeling melanoma in vitro of tubercular infection. Pharmaceutical cardiomyopathy: importance of Defined by Primary Cilia Positive Cells is there a future? Melanoma Semsarian C. Delay to diagnosis amongst and in vivo. Healthcare, 2014; 2(1): 27-46 Research, 2014; 31(5):1239-53 periodic reassessment. Genetics in During Chronic Liver Injury. Journal of Management, 2014 1(2): 127-137 patients with catecholaminergic IF: 4.742 Medicine, 2014 Apr; 16(4): 286-93 Hepatology, 2014 Jan; 60(1):143-51 *corresponding author polymorphic ventricular tachycardia. Bertolino P and Bowen DG. (2014). IF: 5.560 IF: 9.264 International Journal of Cardiology, Primary T cell activation in the liver. Chang GHK, Lay AJ, Ting KK, Zhao Holmes JA, Roberts SK, Ali RJ, Dore 2014, 176 (3): 1402-1404 Book chapter in Encyclopedia of Y, Coleman PR, Powter EE, Formaz- Driscoll E, Ingles J, Semsarian C. Grzelak CA, Sigglekow ND, Watkins DN, GJ, Sievert W, McCaughan GW, IF: 6.175 Medical Immunology (Springer), Preston A, Jolly CJ, Bower NI, Hogan Clinical and genetic characteristics McCaughan, GW. Reply to: “The many Crawford DH, Cheng WS, Weltman Diamond and Davidson Editors. Editors BM, Rinkwitz S, Becker TS, Vadas MA, of hypertrophic cardiomyopathy faces of Hedgehog signalling in the MD, Bonanzinga S, Visvanathan K, Le Couteur DG, Warren A, Cogger V in chief: MacKay and Rose. 899-905 Gamble JR., ARHGAP18: an endogenous patients with end-stage disease: A liver: Recent progress reveals striking Sundararajan V, Desmond PV, Bowden and Bertolino P. (2014). Ultrastructure inhibitor of angiogenesis, limiting tip registry-based study. Heart, Lung and cellular diversity and the importance DS, Matthews GV, Thompson AJ; of the liver sinusoid. Book chapter in Biro M, Munoz M, Weninger W. Targeting formation and stabilizing junctions. Circulation, 2014; 23 (Suppl 2): e8-9 of microenvironments”. The Journal of CHARIOT Study Group, ITPA genotype Encyclopedia of Medical Immunology Rho-GTPases in immune cell migration Small GTPases, 2014; 5(3): 1-15 Hepatology, 2014; 61(6): 1451-1452 protects against anemia during - Autoimmune diseases (Springer), and inflammation. British Journal of Farrell GC, Mridha AR, Yeh MM, Arsov IF: 10.401 peginterferon and ribavirin therapy but Diamond and Davidson Editors. Editors Pharmacology, 2014; 171 (24): 5491-5506 Chapman JR, McCaughan GW, T, Van Rooyen DM, Brooling J, Nguyen does not influence virological response, in chief: MacKay and Rose, 1235-1240 IF: 4.990 O’Connell PJ, Professor Bruce Hall T, Heydet D, Delghingaro-Augusto V, Guilfoyle AP, Deshpande CN, Sadurni Hepatology, 2014 Jun; 59(6): 2152-60 and the ABC, Med J Aust. 2014 Sep Nolan CJ, Shackel NA, McLennan SV, JF, Ash MR, Tourle S, Schenk G, Lim SH, Becker TM, Chua W, Caixeiro NJ, Ng Bonham KS, Orzalli MH, Hayashi K, 15;201(6):322Chen, SH; Zhao, Y; Zhang, Teoh NC, Larter CZ. Strain dependence Maher MJ, Jormakka M. A GTPase Hussein SMI, Puri MC, Tonge PD, WL, Kienzle N, Tognela A, Lumba S, Rasko Wolf AI, Glanemann C, Weninger Y; Zhang, DH. Fucoidan Induces of diet-induced NASH and liver Chimera Illustrates an Uncoupled Benevento M, Corso AJ, Clancy JL, JEJ, de Souza P, Spring KJ. Circulating W, Iwasaki A, Knipe DM, Kagan JC. Cancer Cell Apoptosis by Modulating fibrosis in obese mice is linked Nucleotide Affinity and Release Mosbergen R, Li M, Lee DS, Cloonan N, tumour cells and circulating free nucleic A Promiscuous Lipid-Binding Protein the Endoplasmic Reticulum Stress to diabetes and inflammatory Rate, Providing Insight into the Wood DL, Munoz J, Middleton R, Korn acid as prognostic and predictive Diversifies the Subcellular Sites of Cascades, PLoS One, 2014; 9 (9) phenotype. Liver International, Activation Mechanism Biophysical O, Patel HR, White CA, Shin JY, Gautheir biomarkers in colorectal cancer. Toll-like Receptor Signal Transduction. IF: 3.534 2014 Aug; 34 (7): 1084-1093 Journal 2014; 107(12) L45-L48 ME, Le Cao KA, Kim JI, Mar JC, Shakiba Cancer Letters, 2014; 346 (1): 24-33 Cell, 2014 Feb 13;156(4):705-716 IF: 4.447 IF: 3.832 N, Ritchie W, Rasko JEJ, Grimmond SM, IF: 5.016 IF: 31.957 Cheng R, Tu T, Shackel N, McCaughan Zandstra PW, Wells CA, Preiss T, Rogers GW. Advances in and the future of Femia G, Hsu C, Singarayer S, Sy Guilfoyle A, Deshpande C, Vincent IM, Seo JS, Heck AJR, Nagy A. Routes Liu RJ, Jin Y, Tang WH, Qin LF, Zhang Bovellan M, Romeo Y, Biro M, Boden A, treatments for hepatitis C. Experts RW, Kilborn M, Parker G, McGuire M, K, Pedroso M, Schenk G, Maher to induced pluripotency: A genome XB, Tellides G, Hwa J, Yu J, Martin KA. Chugh P, Yonis A, Vaghela M, Fritzsche Review of Gastroenterology and Semsarian C, Puranik R. Impact of New M, Jormakka M. Structural and wide, multi-omics characterization. Response to Letter Regarding Article, M, Moulding D, Thorogate R, Jegou A, Hepatology, 2014; 8(6): 633-647 Task Force Criteria in the Diagnosis Functional analysis of a FeoB Nature, 2014 Dec; 516(7530): 198-206 “Ten-Eleven Translocation-2 (TET2) Is a Thrasher AJ, Romet-Lemonne G, Roux PP, IF: 2.546 of Arrhythmogenic Right Ventricular A143S G5 loop mutant explained IF:42.324 Master Regulator of Smooth Muscle Cell Paluch EK, Charras G. Cellular control Cardiomyopathy. International Journal accelerated GDP release rate. FEBS Plasticity”. Circulation. 130(8): e72-E72 of cortical actin nucleation. Current of Cardiology, 2014 Feb 1;171(2):179-83 Journal, 2014; 281(9):2254-65 IF: 14.948 Biology, 2014; 24 (14): 1628-1635 IF: 5.509 IF: 4.250 IF : 9.916 6 Scientific Excellence 2014 PUBLICATIONS

Ly D, Taylor JM, Tsatsaronis JA, Nematollahi A, Church WB, Nadvi NA, Rickinson AB, Long HM, Palendira U, Spirito P, Autore C, Formisano F, Assenza Wang Q, Grkovic T, Font J, Bonham S, Yagoub D, Wilkins MR, Lay AJ, Kaczorowski Monteleone MM, Skora AS, Donald Gorrell MD, Sun G. Homology modeling Munz C, Hislop AD. Cellular immune GE, Biagini E, Haas TS, Bongioanni S, Pouwer R, Bailey CG, Moran A, Ryan DC, Hatoum D, Bajan S, Hutvagner G, CA, Maddocks T, Nizet V, West NP, of human Kynurenine aminotranferase III controls over Epstein-Barr virus Semsarian C, Devoto E, Musumeci RM, Rasko JEJ, Jormakka M, Quinn Lai JH, Wu W, Martiniello-Wilks R, Xia P, Ranson M, Walker MJ, McArthur JD, and exploration of its inhibitors binding infection: new lessons from the B, Lai F, Yeates L, Conte MR, Rapezzi RJ, Holst J. Monoterpene glycoside McGowan EM. Sphingosine kinase 1 Sanderson-Smith ML. Plasmin(ogen) properties using molecular docking. clinic and the laboratory. Trends in C, Boni L, Maron BJ. Risk of sudden ESK246 from Pittosporum targets LAT3 isoform-specific interactions in breast Acquisition by Group A Central Nervous System Agents in Immunology, 2014; 35(4); 159-169 death and outcome in patients with amino acid transport and prostate cancer. Molecular endocrinology Streptococcus Protects against C3b- Medicinal Chemistry, 2014 14(1): 2-9 IF: 12.031 hypertrophic cardiomyopathy with cancer cell growth. ACS Chemical (Baltimore, Md.) 2014 28 (11): 1899-1915 Mediated Neutrophil Killing. Journal benign clinical presentation and Biology, 2014; 9 (6), pp 1369–1376 IF: 4.201 of Innate Immunity, 2014;6(2):240-250 Ochiai S, Roediger B, Abtin A, Shklovskaya Ritchie W, Rasko JEJ. Refining microRNA without risk factors. American Journal of IF: 5.356 IF: 4.458 E, de St Groth BF, Yamane H, Weninger target predictions: Sorting the wheat Cardiology, 2014 May 1;113(9):1550-5 Zhang H, Chen Y, Wadham C, McCaughan W, Le Gros G, Ronchese F. CD326(lo) from the chaff. Biochemical and IF: 3.209 Weber-Chrysochoou C, Crisafulli GW, Keane FM, Gorrell MD. Dipeptidyl Macpherson JL, Rasko JEJ. CD103(lo)CD11b(lo) Dermal Dendritic Biophysical Research Communications. D, Kemp AS, Britton WJ, Marks GB. peptidase 9 subcellular localization Clinical potential of gene therapy: Cells Are Activated by Thymic Stromal 2014; 445 (4): 780-784 Stifter SA, Coleman MC, Feng Allergen-Specific IL-5 Responses in and a role in cell adhesion involving towards meeting the demand. Lymphopoietin during Contact IF: 2.281 CG. Regulation of Host Response to Early Childhood Predict Asthma at Age focal adhesion kinase and paxillin. BBA Internal Medicine Journal, Sensitization in Mice. Journal of Mycobacteria by Type I Interferons In Eight. PLoS One, 2014; 9 (5) e97995 Molecular Cell Research, 1853(2):470-480 2014 Mar;44(3):224-233 Immunology, 2014; 193 (5): 2504-2511 Roberts SK, Mitchell J, Leung R, Booth “Bacterial Activation of Type I IF: 3.534 IF:5.3 IF: 1.823 IF: 5.362 D, Bollipo S, Ostapowicz G, Sloss A, Interferons”, Dane Parker (ed), pp McCaughan GW, Dore GJ, Thompson 109- 124. Springer. Switzerland 2014. Weninger W, Biro M, Jain R. Leukocyte Zhou HJ, Chen X, Huang Q, Liu R, Zhang Maron BJ, Ommen SR, Semsarian Osborne B, Yao T-W, Wang X, Chen Y, Kotan A, Crawford DH, Sievert W, Weltman M, migration in the interstitial space of H, Wang Y, Jin Y, Liang X, Lu L, Xu Z, Min C, Spirito P, Olivotto I, Maron MS. LD, Nadvi NA, Herdem M, Mccaughan Cheng W, George J; Australian Liver Sweeting J. and Semsarian C. non-lymphoid organs. Nature Reviews W. AIP1 mediates vascular endothelial Hypertrophic Cardiomyopathy: GW, Allen JD, Yu DMT, Topaloglu AK, Gorrell Association Clinical Research Network, Cardiac Abnormalities and Sudden Immunology, 2014; 14(4): 232-246 cell growth factor receptor-3-dependent Present and future, with MD. A rare variant in human fibroblast Distribution of interferon lambda-3 gene Infant Death Syndrome. Paediatric IF: 33.129 angiogenic and lymphangiogenic translation into contemporary activation protein associated with ER polymorphisms in Australian patients with Respisatory Reviews, 2014. 15: 301-306 responses. Arteriosclerosis, Thrombosis, and cardiovascular medicine. J Am stress, loss of function and loss of cell previously untreated genotype 1 chronic Wong JJ, Holst J. Changes in CpG Vascular Biology, 2014 Mar;34(3):603-15 Coll Cardiol., 2014; 64(1): 83-99 surface localization. BBA Proteins and hepatitis C: Analysis from the PREDICT Tay SS, Wong YC, McDonald D, Wood methylation marks differentiation of IF: 6.338 IF: 15.343 Proteomics, 2014; 1844(7):1248-59 and CHARIOT studies, J Gastroenterol NA, Roediger B, Sierro F, McGuffog CM, human myeloid progenitors to neutrophils. IF: 3.733 Hepatol. 2014 Jan; 29(1):179-84 Alexander IE, Bishop GA, Gamble JR, Stem Cell Investigation 2014; 1:10 Marshall AD, Bailey CG, Rasko Weninger W, McCaughan GW, Bertolino JEJ. CTCF and BORIS in Genome Padang R, Dennis M, Semsarian C, Bannon Scott C, Bonner J, Min DQ, Boughton P*, Bowen DG* (*equal last authors). An Wong JJ-L, Ritchie W, Gao D, Lau KA, Regulation and Cancer. Current PG, Tanous DJ, Celermajer DS, Puranik R. P, Stokes R, Cha KM, Walters SN, antigen expression level threshold tunes Gonzalez M, Choudhury A, Taft RJ, Opinion in Genetics and Detection of serious complications by MR Maslowski K, Sierro F, Grey ST, Twigg S, the fate of CD8 T cells during primary Rasko JEJ and Holst J. Identification Development, 2014 Feb; 24C: 8-15 imaging in asymptomatic young adults with McLennan S, Gunton JE. Reduction of hepatic immune responses. Proc Natl of nuclear-enriched miRNAs during IF: 8.568 repaired coarctation of the aorta. Heart, ARNT in myeloid cells causes immune Acad Sci USA, 2014; 111(25): e2540-9 mouse granulopoiesis. Journal of Lung and Circulation, 2014 Apr; 23(4): 332-8 suppression and delayed wound healing. IF: 9.737 Hematology & Oncology, 2014; 7(1):42 Majumdar SS, Marais BJ, Denholm JT, IF: 1.254 American journal of physiology-cell IF: 4.458 Britton WJ. Drug-resistant tuberculosis: physiology, 2014; 307(4): c349-C357 Tay SS, Wong YC, Roediger B, Sierro F, Lu collaborative regional leadership Pai S, Qin J, Cavanagh L, Mitchell A, IF: 3.674 B, McDonald D, McGuffog CM, Meyer Wong JJ-L, Lau KA, Pinello N, Rasko JEJ. required. Medical Journal of El-Assaad F, Jain R, Combes V, Hunt N, Weninger W, Alexander IE, Heath WR, Epigenetic mechanisms do not commonly Australia, 2014; 200(5): 241-242 NH, Grau GER, Weninger W. Real-Time Semsarian C. Progress on the Bishop GA, Gamble JR, McCaughan silence splicing factors in MDS and AML. IF: 3.789 Imaging Reveals the Dynamics of australia and new zealand sudden GW, Bertolino P* and Bowen DG* Cancer Sci. 2014 Nov;105(11):1457-63 Leukocyte Behaviour during Experimental cardiac death (anzscd) study. (*equal last authors). Intrahepatic IF:3.534 Mitchell AJ, Roediger B, Weninger Cerebral Malaria Pathogenesis. Pathology, 2014; 46(Suppl 1) S21 activation of naive CD4 T cells W. Monocyte homeostasis and PLoS Pathogens, 2014 Jul; 10 (7) IF: 2.657 by liver-resident phagocytic cells. Wright C, Velickovic Z, Brown R, Larsen the plasticity of inflammatory IF: 8.057 J Immunol 193(5): 2087-95 S, Macpherson JL, Gibson J, Rasko JEJ. monocytes. Cellular Immunology, Semsarian C, Sweeting J, Ingles IF: 5.362 Raising the standard: changes to the 2014; 291(1-2): 22-31 Patel K, Shackel NA. Current status of J. Sudden death in athletes: Australian Code of Good Manufacturing IF: 1.874 fibrosis markers. Current Opinion in preventable or inevitable? Heart Tu T, Budzinska MA, Maczurek AE, Practice (cGMP) for Human Blood and Gastroenterology, 2014; May; 30(3): 253-9 Rhythm, 2014; 11(10) 1682-1683 Cheng R, Dibartolemeo A, Warner Blood Components, Human Tissues Moloney FJ, Guitera P, Coates E, IF: 4.103 IF: 5.045 FJ, McCaughan GW, McLennon SV, and Human Cellular Therapy Products. Haass NK, Ho K, Khoury R, O’Connell Shackel NA. Novel aspects of the liver Pathology, 2014 Apr;46(3):177-83 R, Raudonikis L, Schmid H, Mann Prakoso E, Tirnitz-Parker N, Kayali Z, Clouston A, Semsarian C, Bagnall R, Molloy L, & microenvironment in HCC pathogenesis. IF: 2.657 GJ, Menzies SW. Detection of Lee A, Ramm GA, Kench J, Bowen D, Olynyk Kalman J. Exome sequencing identifies a International Journal of Molecular primary melanoma in individuals J, McCaughan GW, Shackel NA. Analysis mutation in the ACTN2 gene in a family Sciences, 2014; 15(6): 9422-58 Wu L, Meoli C, Mangiafico S, Fazakerley at extreme high risk: A prospective of the intrahepatic ductular reaction and with idiopathic ventricular fibrillation, IF: 2.464 D, Cogger V, Mohomad M, Pant H, 2 B Cell Follicles - scientific image five-year follow up study. JAMA progenitor cell responses in hepatitis C virus left ventricular noncompaction, Kang M-J, Powter E, Burchfield J, taken by Summer School Student, Dermatol, 2014, Aug;150(8): 819-27 recurrence post-liver transplantation. Liver and sudden death. BMC Medical Vidot H, Carey S, Allman-Farinelli Xirouchaki C, Stockli J, Kolumam G, IF: 4.306 Transplantation, 2014; 20 (12); 1508-1519 Genetics, 2014; 16;15(1): 99 M, Shackel N. Systematic Review: Gamble J, LeCouteur D, Cooney G, Jarem Edwards, Human Viral & IF:3.793 IF: 2.450 the treatment of muscle cramps in Andrikopoulos S, James D. Systemic Cancer Immunology Laboratory. Mohana-Kumaran N, Hill DS, Allen patients with cirrhosis. Alimentary vascular endothelial growth factor A JD, Haass NK*. Targeting the intrinsic Puranik R, Gray B, Lackey H, Yeates Seth D, Duly A, Kuo PC, McCaughan Pharmacology and Therapeutics, (VEGF A) neutralization ameliorates apoptosis pathway as a strategy for L, Parker G, Duflou J, Semsarian C. GW, Haber PS. Osteopontin 2014; Aug;40(3): 221-32 diet induced metabolic dysfunction. melanoma therapy. Pigment Cell Comparison of conventional autopsy (OPN) is an important mediator IF: 5.478 Diabetes Aug; 63(8): 2656-67 Melanoma Res, 2014; 27(4): 525-39 and magnetic resonance imaging in of alcoholic liver disease. World IF: 8.474 *corresponding author determining the cause of sudden death Journal of Gastroenterology, Wang Q, Beaumont KA, Otte NJ, Font J, IF: 5.839 in the young. Journal of Cardiovascular 2014; 20(36):13088-104 Bailey CG, van Geldermalsen M, Sharp Xia P, Qi Y. Cellular inhibitor of apoptosis Magnetic Resonance, 2014; 16(1):44 IF: 3.870 DM, Tiffen JC, Ryan RM, Jormakka M, protein-1 and survival of beta cells Munoz MA, Biro M, Weninger W. IF: 4.435 Haass NK, Rasko JEJ, Holst J. Targeting undergoing endoplasmic reticulum stress. T cell migration in intact lymph Shackel, NA; Vadas, MA; Gamble, glutamine transport to suppress Vitamins and Hormones, 2014; 95:269-98 nodes in vivo. Current Opinion Rasko JEJ. Innovations: advances JR; McCaughan, GW. Beyond melanoma cell growth. International IF: 2.296 2 B Cell Follicles - scientific image taken by in Cell Biology, 2014; 30: 17-25 in cellular therapies relating to Liver Fibrosis: Hepatic Stellate Cell Journal of Cancer, 2014; 135(5):1060-71. Summer School Student, Jarem Edwards, IF: 8.736 haematological conditions. Pathology, Senescence Links Obesity to Liver IF: 6.198 Human Viral & Cancer Immunology 2014 Feb; 46(Suppl 1): S31 Cancer by Way of the Microbiome. Laboratory IF: 2.657 Hepatology, 2014; 59 (6): 2413-2415 IF: 11.19

6 INVITED PRESENTATIONS

INTERNATIONAL Jormakka M, Structure and function of a Rasko J, Cell and gene therapy; coming to Semsarian C, Genetic basis of SUDEP: the Wong J, Intronic nonsense: A widespread Hare N.J, Microparticles from M. tuberculosis bacterial iron transporter, Department of terms with it all, 5th MTERMS, Malaysia Australian study, Oxford, layer of gene expression control, Stanford infected human macrophages contain Biro M, Cellular actin cortex composition Cell Biology; Department Seminar, Kyoto, Medical School Departmental Seminar, elevated type I interferon inducible proteins and homeostasis resolved by integrating Japan Rasko J, Serendipity and Science; from Semsarian C, False negative genetic California, USA including ISG15 and IFITs, 44th Australasian quantitative imaging and proteomics, Gene Therapy to Cancer via the Genetics of tests, Heart Rhythm Society Meeting, San Society of Immunology Annual Scientific Institute of Molecular and Cell Biology Jormakka M, Structural insights into divalent Aminoaciduria, 5th MTERMS, Malaysia Francisco, USA Wong J, Diverse mechanisms of gene Meeting 2014, Wollongong, NSW Invited Speaker Seminar Series, Singapore, iron transport, Department of Physiology, Rasko J, , CHORI, Oakland, USA expression control: All roads lead to Rome, Malaysia UCLA; Department Seminar, Los Angeles, Semsarian C, Advances in the genetics of Faculty Colloquium, Faculty of Research Hare N.J, Microparticles from M. tuberculosis USA Rasko J, Gene therapy clinical trials: the hypertrophic cardiomyopathy. , The Victor Science and Technology, University of infected human macrophages contain Biro M, Organiser/ Chair, 5th Tissue Australian path to the end of suffering, 20th Change Cardiac Research Institute 15th Malaysia Sarawak, Kota Samarahan, elevated type I interferon inducible proteins Engineering Symposium, ADATE, Sydney, McCaughan G, The End of Interferon Annual ISCT Meeting, Paris, France International Symposium, Sydney, NSW Malaysia including ISG15 and IFITs, Centre of NSW treatment for HCV: a debate, APASL, Research Excellence for Tuberculosis Control Brisbane, QLD Rasko J, Orchestrated intron retention Semsarian C, The Australian Heart Registry, NATIONAL (TB-CRE) Annual Symposium 2014, Sydney, Fazekas de St Groth B, A bioinformatic regulates normal granulocyte differentiation, International Symposium on ARVC, Zurich, NSW approach to flow cytometric data, McCaughan G, Is there such a thing EMBO, Poland Switzerland Beaumont K, Sharp D, Weninger W and International Conference on Systems as protocol immunosuppression in Liver Haass NK, Targeting Rab27a to suppress Hare N.J, Microparticles from M. tuberculosis Biology, Melbourne, VIC Transplantation, APASL, Brisbane, QLD Rasko J, Orchestrated intron retention Seth D, Genetics of alcoholic liver disease, melanoma proliferation and invasion, 2nd infected human macrophages contain regulates normal granulocyte differentiation, 37th Annual RSA Scientific Meeting and 17th National Melanoma Conference, Perth, elevated type I interferon inducible proteins Gorrell M, DPP9 in cell growth adhesion and McCaughan G, Immunosuppression for AIH, EMBO, Polonia Castle Pultusk, Pultusk, Poland Congress of ISBRA Joint Meeting, Bellevue, Australia including ISG15 and IFITs, 2nd Proteomics migration., Tufts University Medical School., APASL, Brisbane, QLD Washington, USA and Beyond Symposium, Sydney, NSW Boston, MA, USA Rasko J, Cell and gene therapy; coming to Bertolino P, Parameters that determine Hersey P, “ Efficacy and safety of the anti McCaughan G, Prevention of HBV post terms with it all, 5th MTERMS, Hotel Bangi- Seth D, Huang E, Duly A, McLennan S, intrahepatic Immunity after primary T cell PD1 MAb MK-3475 in 411 patients with Gorrell M, The protease fibroblast activation Liver Transplant, Japanese Hepatology Putrajaya, Selangor, Malaysia Osteopontin plays a key role in alcohol activation., APASL 2014 Meeting: Australia, melanoma”, MOGA , Sydney, NSW protein as a biomarker and therapeutic Association Single Topic Conference on HBV and high fat diet induced liver injury, 50th Brisbane, QLD target in cancer and chronic liver injury., Infection. , Hiroshima, Japan Rasko J, Serendipity and Science; from International Liver Congress 2015 for the Holst J, Regulation of nutrient uptake 2nd International Conference on Predictive, Gene Therapy to Cancer via the Genetics of European Association for the Study of the Bertolino P, An antigen expression coordinates metabolic adaptations in Preventive and Personalized Medicine., Las McCaughan G, New Therapies for HCV, Aminoaciduria, 5th MTERMS, Hotel Bangi- Liver (EASL), Vienna, Austria level threshold tunes the fate of CD8 T cancer, Garvan Institute, Cancer Research Vegas, USA IHPBA meeting, Seol, South Korea Putrajaya, Selangor, Malaysia cells during primary hepatic immune Division Seminar Series, Sydney, NSW Seth D, Meikle P Lipidomics in Alcoholic Liver responses, Future of Experimental Gorrell M, Fibroblast activation protein is a McCaughan G, Selection of patients for Rasko J, Intron retention provides a hidden Disease, 37th Annual RSA Scientific Meeting Medicine Conference - Inflammation in Holst J, Linking nutrition, cancer and potential biomarker and therapeutic target combined liver and kidney transplantation layer of gene expression control, Institute of and 17th Congress of ISBRA Joint Meeting, Disease and Ageing -, Sydney, NSW diabetes – one branched chain amino acid in diabetes and fatty liver disease., 5th in Hepatorenal Syndrome., IHPBA meeting, Stem Cell Biology & Regenerative Medicine, Bellevue, Washington, USA at a time, University of , World Congress on Diabetes & Metabolism., Seol, South Korea Stanford, CA, USA Biro M, Investigating the early stages of solid Department of Pharmacology Seminar Las Vegas, USA Seth D. T. Morgan, C. Day and GenomALC tumour metastasis, Sail for Cancer Research, Series, Sydney, NSW McCaughan G, Viral Hepatitis and safe Semsarian C, Role of social media in Consortium GenomALC Consortium study Empire Marina, Bobbin Head, NSW Gray B, Challenges of Sport Participation kidney transplantation. , Vietnamese cardiovascular education, Amsterdam to identify genetic risk factors for alcoholic Ingles J, Psychological impact of sudden in Genetic Heart Disease, International Transplant Meeting, Vietnam Medical Centre, Amsterdam, The liver cirrhosis, 37th Annual RSA Scientific Biro M, The actin cortex and cellular cardiac death, Athel Hockey Symposium, Clinical Cardiovascular Genetics Netherlands Meeting and 17th Congress of ISBRA Joint protrusions: from assembly to invasive WA branch of the Human Genetics Society Conference, Brisbane, QLD McCaughan G, Immunosuppression and Meeting, Bellevue, Washington, USA tumour cell migration, Children’s Cancer of Australasia, Perth WA, Australia infection prophylaxis, Vietnamese Transplant Semsarian C, The cardiomyopathies, Reserch Unit Seminar Series, Kids Research Holst J, Regulation of nutrient uptake Meeting, Vietnam International Clinical Cardiovascular Smith A, Best Practices in SLR, CYTO 2014, Institute, Westmead, NSW McCaughan G, Non Alcoholic Fatty coordinates metabolic adaptations in Genetics Meeting, Brisbane, QLD Fort Lauderdale, USA Liver Disease - Detection and Severity cancer, 9th International Conference of McCaughan G, Viral hepatitis and safe Biro M, Investigating the early stages of Assessment, Australian Association of Anticancer Research, Sithonia, Greece liver transplantation, Vietnamese Transplant Semsarian C, The molecular autopsy: from Smith A, Online and New Media Tools for the solid tumour metastasis, Fight on the Clinical Biochemists 52nd Annual Scientific Meeting, Vietnam single genes to exomes, International Well Connected Cytrometry Lab, CYTO 2014, Beaches, Miramare Gardens, Terrey Hills, Meeting, Adelaide, SA Ingles J, The role of the cardiac genetic Clinical Cardiovascular Genetics Meeting, Fort Lauderdale, USA NSW counselor, Heart Rhythm Society’s Annual McCaughan G, Equitable allocation of Brisbane, QLD McCaughan G, AIH – how to treat and Scientific Sessions, Boston, Boston, MA, USA deceased donor liver: The Liver Transplant Tong P, Cutting edge microscopy to Fazekas de St Groth B, Identification and natural history, GESA Gut School, Sydney, Recipient: Criteria for listing and allocation Semsarian C, The ideal model of care, study the immunological and structural Study of Human Tregs, TSANZ satellite NSW Ingles J, Managing the sudden cardiac of organs. Vietnamese Transplant Meeting, International Clinical Cardiovascular composition of skin, College of Life Sciences, workshop, Sydney, NSW death family, International Clinical Vietnam Genetics Meeting, Brisbane, QLD University of Dundee, Mundra PA, Wong G, Huynh K, Barlow CK, Cardiovascular Genetics Conference, Dundee, UK Fazekas de St Groth B, Immunological Duly AMP, Haber PS, Whitfield JB, Meikle Brisbane, QLD Palendira U, An occupying force of memory Semsarian C, The stimulating truth about Disease - The Western Epidemic, PJ, Seth D, Plasma lipids: association with T cells against Epstein Barr Virus, 16th energy drinks. , 1st International Energy Weninger W, Regulation of lung Postgraduate workshop, Australasian Society alcoholic liver disease and potential Ingles J, Genetic counselling prior to testing, International Symposium on EBV and Drinks Conference, Geelong, VIC inflammation by ILC2, Innate Lymphoid Cells for Immunology Annual Scientific Meeting, biomarker, Australian Lipid Meeting, and when not to test, International Clinical associated diseases , Brisbane, QLD 2014, Paris, France Wollongong, NSW Wollongong, NSW Cardiovascular Genetics Conference, Semsarian C, The molecular autopsy. , 7th Brisbane, QLD Palendira U, Selective retention of effector Asia Pacific Heart Rhythm Society Scientific Weninger W, Perivascular macrophages Fazekas de St Groth B, Human Tregs, Palendira U, Understanding human cellular memory CD8+ T cells within human spleen, Meeting, New Delhi, India. regulate the response to S. aureus infection, TSANZ workshop, Australasian Society for immunology through common viral Ingles J, Clinical genetic screening of World Immune Regulation Meeting – VIII, 14th Hunter Cellular Biology Meeting, Immunology Annual Scientific Meeting, infections, Peter Doherty Institute Seminar, family members, Scientific Sessions of the Davos, Switzerland Semsarian C, Determining which variants Pokolbin, NSW, Australia Wollongong, NSW Melbourne, VIC American Heart Association, Chicago, IL, are disease-causing., 7th Asia Pacific Heart USA Rasko J, Intron retention provides a hidden Rhythm Society Scientific Meeting, New Weninger W, Role of perivascular Fazekas de St Groth B, Burnet Oration: Palendira U, An occupying force of memory layer of gene expression control, Institute of Delhi, India. macrophages in neutrophil recruitment to Roads less travelled: unforseen directions T cells against an oncogenic virus - Resident Ingles J, Conveying a probabilistic gene Stem Cell Biology & Regenerative Medicine, the skin, Keystone Conference on Molecular in immunological research, Australasian memory T cells in humans, ANZAC institute result to the family, Asia-Pacific Heart Stanford University, California, USA Semsarian C, Update in genetics of Cell Biology of Macrophages in Human Society for Immunology Annual Scientific seminar, Sydney, NSW Rhythm Society Scientific Sessions, New hypertrophic cardiomyopathy, 7th Asia Diseases, Santa Fe, NM, USA Meeting, Wollongong, NSW Delhi, India Rasko J, Intronic Nonsense: hidden layers Pacific Heart Rhythm Society Scientific Palendira U, An occupying force for an of gene expression control uncovered by Meeting, New Delhi, India. Weninger W, Lymphotyes in the skin: The Gamble J, New concepts for senescence oncogenic virus - Resident memory T cells Ingles J, Psychological wellbeing of the studying granulopoiesis, HUGO, Geneva, family is growing, Inflammatory Skin Disease in the vascular System, Australian Vascular in humans, Inflammation and infection surviving family, Asia-Pacific Heart Rhythm Switzerland Semsarian C, Sudden cardiac death Summit: , Vienna, Austria Biology Scentific Metting, Adelaide, SA Research Centre Seminar, UNSW, Sydney Society Scientific Sessions, New Delhi, India risk assessment in hypertrophic Rasko J, Intronic Nonsense: a widespread cardiomyopathy, 7th Asia Pacific Heart Weninger W, Perivascular macrophages as Gamble J, New concepts for senescence Jormakka M, When microscopes are not yet hidden layer of gene expression control, Rhythm Society Scientific Meeting, New regulators of skin snd CNS inflammation, in the vascular System, Inaugural Futures of enough: structural biology and insights HUGO Geneva, Geneva, Switzerland Delhi, India. Chemotactic Cytokine Gordon Research Experimental Medicine, Sydney, NSW into metal transport, The 7th Cell Biology, Conference, West Dover, VT, USA Developmental Biology, and Systems Biology meeting, Kyoto, Japan

Meet our Scientists 6 INVITED PRESENTATIONS Ellie Powter

Research Assistant Rasko J, Stem cell research, 10th Annual Symposium, Semsarian C, Progress on the ANZSCD Study, Pathology Update, Medivision Menzies Research Institute, University of Melbourne, VIC , , Hobart, TAS Centenary is the whole package: Semsarian C, Cardiac genetic testing in 2014, UWA Symposium, Rasko J, Stem cell research, 10th Annual Perth, WA a world class research facility with symposium,Medivision, Hobart, TAS Rasko J, Intronic nonsense: hidden layers of gene control Semsarian C, Getting to the heart of sudden death, Athel state-of-the-art equipment, weekly uncovered by studying granulopoiesis, 26th Lorne Cancer Hockey Symposium, Perth, WA seminars from brilliant national and Conference, Lorne, VIC Semsarian C, My patient with inherited cardiac arrhythmia international researchers and staff Rasko J, Getting something for nothing? Intron retention syndromes – the role of genetic testing., UCAD, Sydney, NSW commonly regulates gene expression, 35th Lorne who are leaders of their field. To top it Conference on the Organisation and Expression of the Semsarian C, Genetic basis and medical assessment of HCM Genome, Lorne, VIC patients, Baird Conference, Sydney, NSW off, Centenary is nestled between RPA

Rasko J, Getting something for nothing? Intron retention Semsarian C, Social media and health care. , Expert Viewpoints Hospital and the University of Sydney, commonly regulates gene expression, 35th Lorne Meeting, Sydney, NSW Conference on the Organisation and Expression of the so there is always a mix of clinicians, Genome, Lorne, VIC Semsarian C, Sudden death in 2014, FRACP RPA BPT Revision Course, Sydney, NSW scientists and students to collaborate Rasko J, Intronic Nonsense: hidden layers of gene expression control uncovered by studying granulopoiesis, Semsarian C, Update on genetic heart diseases, Sydney with and learn from.” 26th Lorne Cancer Conference , Lorne, VIC Cardiology Group Educational Seminar, Sydney, NSW

Rasko J, Innovations-Advances in cellular therapies relating Semsarian C, Getting to the heart of sudden death, ASMR to haematological conditions, RCPA, Pathology Update Meeting, Sydney, NSW 2014, Melbourne, VIC Semsarian C, Caffeine, drugs and the heart., Australian Rasko J, Updating global therapies, 7th World Congress on Cardiovascular Health and Rehabilitation Association Meeting, Tissue Banking, Melbourne, VIC Sydney, NSW

Rasko J, Gene and cell therapy update, Pathology Update, Semsarian C, What can we do about HCM? , CV Forum, Melbourne, VIC Sydney, NSW

Rasko J, Update in global therapies, WCTB7, Melbourne, Semsarian C, Preventing sudden cardiac death in the young. , VIC Sydney Innovation and Research Symposium, Sydney, NSW

Rasko J, Heterogeneity in the microRNA-ome at CML Semsarian C, Getting to the Heart of Sudden Cardiac Death, diagnosis, NDLR 2014 Conference, Outrigger Little Hastings, 21st Century Public Lecture Series, University of Sydney, Sydney Noosa, QLD NSW

Rasko J, Heterogeneity in the microRNA-ome at CML Semsarian C, Genetic basis of hypertrophic cardiomyopathy: dignosis, NDLR, Noosa, QLD translation to clinical practice, Bosch Institute Annual Scientific Meeting, University of Sydney, Sydney NSW Rasko J, Intron retention provides a hidden layer of gene expression control, Harry Perkins Institute of Medical Semsarian C, Are there individuals for whom strenuous exercise Research, Perth is too risky? , Exercise is Medicine Meeting, , University of Sydney, Sydney NSW Rasko J, Intron retention provides a hidden layer of gene expression control, Harry Perkins Institute of Medical Semsarian C, Genomics in cardiac clinical practice: shaping Research, Perth, WA the future of cardiology. , Cardiovascular Symposium, Westmead Hospital Week, Westmead Hospital Week, Sydney Rasko J, Getting something for nothing?, Intron retention NSW downregulates gene expression, Lowy Cancer Research Centre, UNSW, Kensington Campus, Randwick, NSW Semsarian C, Genetic advances in cardiology, Medical Genetics Symposium, Westmead Hospital Week, Sydney NSW Rasko J, Getting something for nothing? Intron retention commonly regulates gene expression, Lowy Cancer Semsarian C, The clinician researcher: how to make it happen, Research Centre, UNSW, Sydney NSW University of Sydney Early Career Researcher Seminar, Woolcock Institute, Sydney NSW Rasko J, Intron retention provides a hidden layer of gene expression control, Illawarra Health and Medical Research Semsarian C, SUDEP – Future Strategies, Epilepsy Research Institute, Wollongong, NSW Meeting, Yarra Valley, VIC

Rasko J, Intron retention provides a hidden layer of gene Tu T, Microvesicles: a window into the liver, Australian Centre for expression contro, Illawarra Health and Medical Research HIV and Hepatitis Virology Workshop 2014, Lorne, VIC Institute, Wollongong, NSW Tu T, Non-driver Mutations in Hepatocellular Carcinoma Roediger B, In vivo analysis of mast cell homeostasis in Genomes, Sydney Catalyst Post-Graduate and Early Career the skin, 44th Australasian Society for Immunology Annual Research Symposium, Sydney, NSW Scientific Meeting, Wollongong, NSW Wong J, Intron retention and its regulation by DNA methylation, Semsarian C, Update on the ANZSCD Study, ASMR Meeting, Joint Australia Japan RNA Meeting, Sydney, NSW Melbourne, VIC

6 2014 GRANT RECIPIENTS

Nicholas King, Ian Campbell, Barbara Fazekas De St Australian Research Council Equipment Groth, Stuart Cordwell, Louis Rendina, Peter Gunning, Merlin Crossley, Miles Davenport, Philip Hogg, John Pimanda, Ewa Goldys, Dayong Jin, Mark Molley

Jodie Ingles Australian Rotary Health research Fund Scholarship

Maté Biro, Nikolas Haass, Wolfgang Weninger Cancer Australia Project

Justin Wong Cancer Institute NSW Early Career Fellowship

Kim Beaumont Cancer Institute NSW Early Career Fellowship

Maté Biro Cancer Institute NSW Early Career Fellowship

Devanshi Seth Commonwealth of Australia Project

Genevieve Almouzni, Adam Cook Epigenesys Network of Excellence Project

Chris Semsarian, Jodie Ingles HeartKids Project

Chris Semsarian Mamma Lena and Dino Gustin Foundation Research

Jennifer Gamble Mirrx Therapeutics A/S Project

Renjing Liu National Australia Bank Project

Helen McGuire National Health & Medical Research Council Early Career Fellowship

Chris Jolly, Adam Cook, Wolfgang Weninger, National Health & Medical Research Council Project Barbara Fazekas de st Groth, Robert Brink

Eddy Thientosapol National Health & Medical Research Council Project

Jodie Ingles, Chris Semsarian, Julie Redfern, National Health & Medical Research Council Project Nadine Kasparian

John Rasko, William Ritchie, Jeffrey Holst, National Health & Medical Research Council Project Charles Mulligan, Matthais Selbach, Timothy Hughes, Justin Wong, Natalia Pinello Gini

Nicholas Shackel, Goeff McCaughan, Sue McLennan, National Health & Medical Research Council Project Fiona Warner, Alexandra Sharland, James Kench, Christine Yee Meet our Scientists Robert Cheng National Health & Medical Research Council Project Wolfgang Weninger, Neville Firth, Andrew Mitchell National Health & Medical Research Council Project

Dr Chandrika Deshpande Xiangjian Zheng National Health & Medical Research Council Project

Structural Biology – Breast Cancer Jai Li, Jennifer Gamble, Mathew Vadas National Health & Medical Research Council Scholarship

John Rasko, Charles Bailey, David Adams, Jeffrey Holst, New South Wales Cancer Council Project “I work with a protein called Breast Cancer William Ritchie, Charles Millighan, Victor Lobanenkov, Joel Makay Resistance Protein (BCRP), one of the most important proteins known to play a critical role John Rasko, Elaile Mardis, David Adams, Charles Bailey, New South Wales Cancer Council Project Lyndal Anderson, Selvan Panther, Victor Lobanenkov, in causing resistance to anti-cancer drugs Amy Marshall in patients, thus impeding treatment. Renjing Liu Perpetual Trust Project Qian Wang, Andreas Evdokiou, Ronald Quinn, Prostate Cancer Foundation of Australia Young Investigator Project Jeffrey Holst Grant My project, through a basic science approach, Robert Cheng Sydney Catalyst Travel addresses the need for improved health care Mark Gorrell The Rebecca L. Cooper Foundation Equipment for cancer patients by facilitating the design and development of more effective drugs.” Warwick Britton The Rebecca L. Cooper Foundation Equipment Charles Bailey Tour de Cure Equipment Organisational 6 COLLABORATIONS STRUCTURE

A.O. Ordine Mauriziano di , Royal Children’s Hospital, University of California San Diego, Torino, Torino, Italy Newtown, NSW Melbourne, VIC California, USA

Aarhus University, Aarhus, Jai Tong University, Royal Hospital for Sick Children, University of California San Denmark Shanghai, China Glasgow, Scotland Francisco, California, USA Ageing

Alma Mater Studiorum, John Hunter Hospital, Royal Melbourne Hospital, University of Freiburg, Università di Bologna, Newcastle, NSW Parkville, VIC Freiburg im Breisgau, Germany Bologna, Italy. Bioinformatics Johns Hopkins University, Royal Perth Hospital, Perth, WA University of Glasgow, Austin Hospital, Melbourne, VIC Maryland, USA Glasgow, Scotland Royal Prince Alfred Hospital, Australian National University. Kyoto University, Kyoto, Japan Camperdown, NSW University of Melbourne, Gene & Stem Canberra, ACT Melbourne, VIC Origins of Cancer La Trobe University, Seoul National University, Cell Therapy , Melbourne, VIC Melbourne, VIC Gwanak District, South Korea University of New South Wales, Sydney, NSW Canberra Hospital, Life Science Institute, Macrogen Singapore Immunology Canberra, ACT Inc, Seoul, South Korea Network, Singapore, Malaysia University of Newcastle, Immune DNA Repair Callaghan, NSW Imaging Careggi University Hospital, Liverpool Hospital, Sir Charles Gairdner Hospital, Florence, Italy Liverpool, NSW Perth, WA University of Queensland, Brisbane, QLD Centre national de la Loma Linda University Medical Southern General Hospital, recherche scientifique, Centre, California, USA Glasgow, UK University of Sydney, Liver Paris, France Sydney, NSW Immunology Malaghan Institute of Medical St George Hospital, Centro di Coordinamento Research, Wellington, Kogarah, NSW University of Toronto, Sperimentazioni Cliniche, New Zealand Toronto, Canada Istituto Toscano Tumori/Azienda St Vincents Hospital, Fitzroy, VIC Liver Injury Liver Cell Biology Ospedaliero-Universitaria Max Planck Institute of University of Washington, Careggi, Firenze, Italy Moleculat Cell Biology and Stanford University, Stanford, Seattle, Washington, USA & Cancer Genetics, Dresden, Germany California, USA PA/Office Molecular Columbia University, University of , New York, USA Mayo Clinic Rochester, Sun Yet-sen University, Perth, WA Assistant Director Manager Hepatology Minnesota, USA Guangshou, China Molecular Cukurova University, University of Western Sydney, Board of Executive Cardiology Adana, Turkey McGill University, The Alfred Hospital, Melbourne, South Penrith, NSW Governors Director Montréal, Canada VIC Curtin University, Perth, WA University of Wollongong, Scientific Advisory Minneapolis Heart Institute The International Institute of Wollongong, NSW Board Structural Deptt of Forensic Medicine Foundation, Minneapolis, USA Molecular and Cell Biology, Biology Monash University VIC Warsaw, Poland University of Zurich, Zurich, Monash University, Switzerland Diamantina Institute, Melbourne, VIC The John Curtin School of Woolloongabba, QLD Medical Research, Acton, ACT Utrecht University, Utrecht, T Cell Mount Sinai Hospital New York, Netherlands Duke University, Durham, New York, USA The for Infection Biology North Carolina, USA and Immunity in Society, Victor Chang Cardiac Research Murdoch Children’s Research Sydney, NSW Institute, Sydney, NSW Ente Ospedaliero Cantonale, Institute, Parkville, VIC Bellinzona, Switzerland The University of Adelaide, Victorian Infectious Diseases Tuberculosis Nambour Hospital, Adelaide, SA Reference Laboratory, Research Feinstein Institute, New York, USA Nambour, QLD Parkville, VIC Tufts Medical Center Boston, Flinders University, Adelaide, SA National Institute of Allergy Massachusetts, USA Westmead Hospital, Diseases of and Infectious Disease Westmead, NSW Fremantle Hospital, Bethesda, Maryland, USA Tufts University School Vascular the Aorta Femantle, WA of Medicine Boston, Winstar Institute, Biology National Lung Hospital, Massachusetts, USA Philadelphia, USA Cell Signalling Fudan University, Hanoi, Vietnam Shanghai, China Università Sapienza, Roma, Italy Woolcock Institute, Sydney, NSW Nepean Hospital, Chief Operating Garvan Institute of Medical Kingswood, NSW Université de Montréal, Yale University, New Haven, Animal Facility Research, Darlinghurst, NSW Montréal, Canada Connecticut, USA Officer Netherlands Proteomics Centre, Gold Coast Hospital, Utrecht, Netherlands Universiti Sains Malaysia, Yeshiva University New York, New Building Southport, QLD George Town, Malaysia York, USA Operations Northern Health Melbourne Fundraising Greenslopes Hospital, Epilepsy Research Centre, University College London, Zhenjiang Hospital, Jiangsu, and Marketing Brisbane, QLD Epping, VIC London, England China Finance Griffith University, Nathan, QLD Princess Alexandra Hospital, University Hospital Hamburg- Zhenjiang University, Hangzhou, Woolloongabba, QLD Eppendorf, Hamburg, Germany China Guangzhou General Hospital Human of Guangzhou Military QIMR Berghofer Medical University of Adelaide, Resources Command, Guangdong, Research Institute, Adelaide, SA China Brisbane, QLD University of Birmingham, Cytometry, Hanoi Medical University, Raudonikis Database Services, Birmingham, England Imaging & IT Hanoi, Vietnam Mount Colah, NSW University of British Columbia, Harvard University, Royal Brisbane Hospital, Vancouver, Canada Grants Massachusetts, USA Herston, QLD www.centenary.org.au /centenaryinstitute @centenaryinst

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