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Coronavirus Disease 2019 (COVID-19) Transmission, Risk Factors, Prevention and Control: a Minireview Oluwaseun Awosolu1,2* and Oluwole Oladele2

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Coronavirus Disease 2019 (COVID-19) Transmission, Risk Factors, Prevention and Control: a Minireview Oluwaseun Awosolu1,2* and Oluwole Oladele2 ISSN: 2474-3658 Awosolu and Oladele. J Infect Dis Epidemiol 2020, 6:145 DOI: 10.23937/2474-3658/1510145 Volume 6 | Issue 4 Journal of Open Access Infectious Diseases and Epidemiology MINI REVIEW Coronavirus Disease 2019 (COVID-19) Transmission, Risk Factors, Prevention and Control: A Minireview Oluwaseun Awosolu1,2* and Oluwole Oladele2 1 Check for School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia updates 2Department of Biology, Federal University of Technology, Akure, Nigeria *Corresponding author: Awosolu Oluwaseun Bunmi, School of Biological Sciences, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia; Department of Biology, Federal University of Technology, Akure, Nigeria it was named as 2019 novel coronavirus (2019 nCoV) by Abstract World Health Organization (WHO). However thereafter, Coronavirus disease 2019 (COVID-19) caused by severe it was renamed and announced as Coronavirus disease acute respiratory syndrome coronavirus 2 (SARS-CoV-2) th which was initially named 2019 novel coronavirus (2019 2019 (COVID-19) on 11 February 2020 [2,3]. In the nCoV) have continued to spread at an alarming rate across same vein, the International Committee on Taxonomy the globe. It was declared as a pandemic by World Health of Viruses (ICTV) announced the new name of this novel Organization (WHO) due to its worldwide exponential spread virus as severe acute respiratory syndrome coronavirus and impact leading to high morbidity and mortality. General- day-to-day activities was heavily destabilized due to lock- 2, SARS-CoV-2 [4]. Currently, the World Health Orga- down and Movement Control Order (MCO) policy which are nization (WHO) has announced this novel coronavirus some of the most effective preventive and control measures disease 2019 (COVID-19) to be pandemic infectious that were employed by many countries. These measures disease on March 11, 2020 [2]. The causative organism however eventually had serious detrimental and devastat- of this disease is known to be severe acute respirato- ing effect on health, education, governance and economy worldwide. In spite of all the preventive and control mea- ry syndrome coronavirus 2 (SARS-CoV-2). It belongs to sures put in place, COVID-19 continue to spread and ravage the family Coronaviridae, subfamily Coronavirinae and many areas of the world. Currently there is still no sufficient, genus betacoronavirus respectively [5-7]. The corona- reliable and scientifically sound epidemiological information viruses are basically classified into alphacoronavirus- on COVID-19 transmission dynamic, risk factors, treatment, prevention and control upon which management and con- es, betacoronaviruses, gammacoronaviruses and del- tainment strategy can be adequately based. Thus, this mini- tacoronaviruses. Alphacoronaviruses and betacoronavi- review provides a summary of the transmission, risk factors, ruses are both infectious and pathogenic to mammals prevention and control of COVID-19 disease worldwide. while gammacoronaviruses and deltacoronaviruses Keywords majorly infects birds [8-11]. Coronavirus disease 2019 SARS-CoV-2, Coronavirus disease 2019, COVID-19, Dis- was originally documented in December 2019 from Wu- ease transmission, Infectious disease, Risk factors han, a highly populous, fast-growing capital city of Hu- bei province which is a central route to many parts of Introduction China with different types of transportation means such as buses, cars, trains and airplanes linking many parts of Coronavirus disease 2019 is a highly devastating the country [11,12]. Obviously, the Whole-genomic se- contagious disease of serious public health concern that quence of this novel coronavirus infectious disease has is increasingly spreading at an alarming rate in several proven that it is similar to the two previously recognised countries worldwide. It currently remains the deadliest coronaviruses which include the Middle East respirato- coronavirus in this 21st century [1]. In the first instance, ry syndrome (Mers) and severe acute respiratory syn- Citation: Awosolu O, Oladele O (2020) Coronavirus Disease 2019 (COVID-19) Transmission, Risk Fac- tors, Prevention and Control: A Minireview. J Infect Dis Epidemiol 6:145. doi.org/10.23937/2474- 3658/1510145 Accepted: July 16, 2020: Published: July 18, 2020 Copyright: © 2020 Awosolu O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Awosolu and Oladele. J Infect Dis Epidemiol 2020, 6:145 • Page 1 of 5 • DOI: 10.23937/2474-3658/1510145 ISSN: 2474-3658 drome (Sars) isolated from bat in china [13]. reported that faecal-oral transmission is not a feasible mean of COVID-19 transmission [30]. Presence of this The high transmission capacity of COVID-19 con- COVID-19 virus has also been confirmed in blood [29]. tagious disease have really enhanced the worldwide Likewise, viral RNA has been observed to be present spread at an alarming rate thereby causing morbidity in serum [16]. However, transmission through blood is and mortality which in turn impacted seriously on the unlikely since respiratory viruses in general are not rec- national and global economy. As such, WHO have clas- ognized as being transmitted through blood. Addition- sified risk assessment of COVID-19 as very high [14]. As ally, there are no documented cases of COVID-19 being of Wednesday, 27th of May 2020 at 01:00 GMT, an esti- transmitted through blood. Furthermore, sexual means mated worldwide number of deaths have increased to of transmission is unlikely because there is no substan- 345,752 and over 5,451,532 cases were recorded in 217 tial proof of the existence of SARS-CoV-2 inside the vag- countries and territories [15]. This high transmission has inal swap samples of some selected COVID-19-infected led to closure and lockdown of both public and private patients [31]. Also, vertical transmission from mother to organizations worldwide in order to curtail the infec- child has not been documented. Documented reports tious disease. Therefore, in order to quickly control this have shown that fluid from amnion, cord blood, milk COVID-19 health crisis, there is a necessity for enough from breast-feeding mother and even swabs from ne- and updated epidemiological information on infection onate’s throat were not positive for COVID-19 infection transmission dynamics, risk factors, prevention and [32]. control. This information can subsequently be used to educate the general populace and thereby enhance in- Risk Factors for COVID-19 Transmission fection control. Though infection is usually due to exposure to the Mode of Transmission virus either directly or indirectly, there are some fac- tors that are responsible. These factors may include; a) The major route of transmission of COVID-19 is from Human factor such as age, sex, blood group, immunity, person-to-person via respiratory droplets and direct personal hygiene, underline pre-existing diseases and personal and physical contact within the community travel history to a COVID-19 endemic country b) Envi- setting as indicated by currently available evidences ronmental factor such as temperature and humidity, [16-21]. This Person-to-person transmission route can and c) Occupations that may predispose some frontline be through respiratory droplets which can be enhanced health professional workers to the virus [16,17,33,34]. by physical body contact through handshake, hugging, kissing and sex due to close physical contact. Similar- Though all age groups including infants, children, ly, coronavirus can be released in respiratory droplets grown-ups and elderly exposed to the virus are suscep- through sneezing and coughing. When the respiratory tible, patients with lower immune system such as the droplets released come in contact with mucous mem- elderly and those with other underline diseases (im- brane of the eyes, nose and mouth of an individual di- munocompromised) are more prone to developing in- rectly or indirectly through contaminated agents and fections and complications and this may lead to fatality surfaces (such as Automated Teller Machines and note particularly in older ones [16,17]. Moreover, Wang and currencies, electronic gadgets including phones and lap- colleagues [35] reported that only few cases of infants tops, door handles and handrails, lift or elevator buttons and children have been observed. Many other studies and fomites including cloths, utensils and furniture), in- have shown that children are less likely at risk of severe fection may likely occur [22-25]. COVID-19 infection while few that contracted infection only show mild and moderate infection and symptoms Transmission can also be airborne as it was recent- [36-40]. Additionally, with regards to sex, more male ly proven under laboratory condition that respiratory have been observed to be infected with COVID-19 com- droplets of smaller size which is also called aerosols can pared to their female counterparts [17]. remain in air for approximately three hours [26]. Guan and colleagues [27] also showed that this infectious dis- Furthermore, it has been proven that while those ease can be transmitted in aerosol especially in environ- who have blood group O may be protected against se- ment with low air circulation. However, it is still unclear vere COVID-19, individuals having blood group A are whether the virus remains viable and infectious from more susceptible
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