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P Phd in Pharma Aceutic Cal Scie Ences PhD in Pharmaceutical Sciences Last modified July 13, 2010 The current Ph.D. in Pharmaceutical Sciences with specialization in Pharmacy graduate program is offered by the Department of Pharmaceutics. The departmental faculty has decided to use 'track' method for accommodating the diversityy of the Department's graduate population, its multi- and interdisciplinary. The focus of the Department of Pharmaceutics, whiich houses the Center for Drug Discovery, differs sufficiently from that of other departments as to justify a specialization. The uniqueness of the department is evident in present reesearch activities which encompass basic, applied and clinical investigations in the areas of Biopharmaceutics and Pharmacokinetics, Pharmaceutical Biotechnology, Pharmaceutical Analysis, Drug Delivery, and Drug Discovery. Specifically, Biopharmaceutics and Pharmacokinetics, encompasses the absorption, distribution, metabolism and excretion of drugs in animals and humans, and the relationship between drug concentration and effect; Pharmaceuutical Biotechnology includes molecular biology, immunology, and aspects of the delivery off peptide and protein drugs; Pharmaceutical Analysis involves the application of spectroscopy, chromatography, extraction, electrophoresis, immunoassays, and radioisotope assays to drug determination; Drug Delivery includes physical, biological and chemical approaches to drug delivery, formulation and evaluation of dosage forms; and Drug Discovery is associated with receptor-oriented/retrometabolic drug design, computer assisted drug design, chemical/physical approaches to controlled drug delivery, pharmacokinetic-pharmacodynamic correlation approach to improved therapeutic index. 1 Objectives of the Ph.D. Program Faculty Adjunct Faculty Governance Recruitment of Students Admission Procedures Financial Assistance Selection of Discipline for Degree and Major Professor Supervisory Committee Curriculum Qualifying Examination Final Examination Specific Requirements for the Master of Science in Pharmacy Degree The objectives of the Ph.D. program in the Department of Pharmaceutics are: To provide a foundation in the pharmaceutical sciences in general, as well as in the specific tracks identified, with emphasis on pharmacokinetics, biopharmaceutics, pharmaceutical analysis, pharmaceutical technology/drug delivery, pharmacodynamics, pharmaceutical biotechnology, and drug design and discovery. To educate individuals capable of conducting independent research and with in- depth specialized knowledge in one of the above areas and to provide a solid educational, technical and experiential foundation for students in the industrial, academic, governmental or other arenas. To provide an environment that nurtures and stimulates the research interests and the intellectual advancement of students and faculty, including a forum for scientific and professional discussion. Faculty Nicholas Bodor, PhD, Graduate Research Professor, Director, Center for Drug Discovery Research Interests: Design of drugs with improved therapeutic index, based on retrometabolic concepts, design of new chemical and physical delivery systems, computer assisted drug design, drug transport and metabolism, and theoretical mechanistic organic chemistry. Ongoing research is performed in all of the areas mentioned. 2 Veronika Butterweck, PhD, Assistant Professor, Research Interests: Research program focuses on the study of herbal medicines with CNS activity. Specific areas of focus include the investigation of plants with antidepressant or anxiolytic activity, phytomedicines for the treatment of restlessness and sleep disturbances and herbal remedies for the prevention of alcohol dependency. Hartmut Derendorf, PhD, Professor of Pharmaceutics Research Interests: Correlation of pharmacokinetic and pharmacodynamic behavior of drugs (corticosteroids, analgesics, antibiotics); analysis of drugs and metabolites in biological fluids by HPLC- pharmacodynamic evaluations by pharmaco-electroencephalography (EEG); pharmacokinetics in sickle cell patients. Reginald Frye, PharmD, PhD, Associate Professor Research Interests Dr. Frye's clinical research program has focused on the identification and characterization of factors that contribute to interindividual variability in drug response. Current focus is on genetic and non genetic (e.g., age, disease) factors that cause variability in drug metabolism, which can be assessed with in vivo probes that can measure the activity of specific drug- metabolizing enzymes in individual subjects. Dr. Frye has received funding for his research from the Pharmaceutical Industry and the National Institutes of Health. Leslie Hendeles, PharmD, Professor Research Interests: Leslie Hendeles, PharmD, is Professor of Pharmacy and Pediatrics in the Colleges of Pharmacy and Medicine, at the University of Florida. He received his PharmD degree from the University of Southern California in 1969. His current interests are improving adherence to asthma medications and delivery of inhaled drugs to young children. Dr. Hendeles has authored numerous articles and book chapters on the clinical pharmacology of drugs for asthma and allergic rhinitis. He has received national recognition-for outstanding contribution to the literature from both the American Society of Hospital Pharmacists and the American College of Clinical Pharmacists as well as the American Pharmaceutical Association's award for Lifetime Research Achievement. He is a consultant to the FDA's Pulmonary Division and serves on the Coordinating Committee of NIH's National Asthma Program . The University of Southern California selected him as their 1993 Outstanding Alumnus, and students in the Working Professional Pharm.D. program at UF selected him as their Outstanding Faculty of the Year for 2002. Dr. Hendeles provides advice on drug therapy to physicians and teaches in the Pediatric Pulmonary Clinic at UF. 3 Guenther Hochhaus, PhD, Professor of Pharmaceutics, Research Interests: Dr. Hochhaus' research includes the development of novel analytical techniques for the measurement of drugs in biological fluids by chromatographic and immunological techniques- the metabolism, pharmacokinetic and pharmacodynamic properties of opioid peptides, pharmacokinetic/dynamic (PK/PD) behavior of anti-asthmatic drugs and their relevance for the formulation of targeted pulmonary delivery systems. Jeffrey Hughes, PhD, Professor of Pharmaceutics, Research Interests: Dr. Hughes' long term goals are to elucidate the physicochemical parameters of antisense oligonucleotides and other macromolecules which influence their cellular permeability and disposition. After a basic understanding is achieved he intends to use these principles to develop better delivery systems for oligonucleotides and other biotechnology derived products. Julie Johnson, PharmD, FCCP, BCPS, Professor and Chair, Dept. Pharmacy Practice Research Interests: Dr. Johnson's research focus is cardiovascular drug pharmacogenomics, disease-gene associations that may be relevant to pharmacogenomics, and the influence of race/ethnicity on drug response and pharmacogenomics. She currently has studies ongoing in the areas of hypertension, heart failure, ischemic heart disease and obesity, with a primary focus on proteins that are drug targets and the impact of their genetic polymorphisms on drug response and disease. Her research has been continuously funded by the National Institutes of Health and/or the American Heart Association since 1990. Taimour Y. Langaee, MSPH, PhD, Research Assistant Professor, Dept. Pharmacy Practice Taimour Y. Langaee, MSPH, Ph.D., is Research Assistant Professor in the Department of Pharmacy Practice at the University of Florida (UF) College of Pharmacy and Director of the UF Center for Pharmacogenomics Genotyping Core Laboratory. Before joining the UF faculty in 2002, he completed three years of post-doctoral fellowship in Immunology and Molecular Biology, and Microbiology and Molecular Genetics working on developing HIV vaccine at the College of Medicine University of Montreal and High Density DNA chips for Pseudomonas aeruginosa at the College of Medicine University of Florida. 4 Dr. Langaee's research interests are focused on pharmacogenetics (genetic-based variability in drug response) in cardiovascular and auto-immune diseases and developing microarray-based technology methods to facilitate disease diagnosis, genotyping of patients and discovering disease-gene associations. Cary Mobley, PhD, Clinical Associate Professor Research Interests: Use of liposomes for pulmonary delivery and as oral vaccine adjuvants. Conceptual integration of the pharmacy curriculum. Anthony Palmieri III, PhD, RPh, Clinical Associate Professor Dr. Palmieri's major responsibilities include licensing of pharmaceutical and life sciences intellectual property. Palmieri holds a BS and MS in pharmacy from the University of Rhode Island and the Ph.D. from the University of Georgia. Prior to his present position he was at The Upjohn Company for sixteen years. Palmieri was Professor of Pharmacy at the University of Wyoming. He is the author of numerous scientific, academic, and historical papers. He served as the Laboratory Editor for the third edition of the Handbook of Pharmaceutical Excipients. Palmieri is very active on the national level of Kappa Psi Pharmaceutical Fraternity and is currently the national vice-president. Palmieri is past chairman of APRS. Currently he is Chair-elect of the Basic Sciences section. He is a fellow of APhA-APRS
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