Degenerative Spondylolisthesis
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Vertebral Column and Thorax
Introduction to Human Osteology Chapter 4: Vertebral Column and Thorax Roberta Hall Kenneth Beals Holm Neumann Georg Neumann Gwyn Madden Revised in 1978, 1984, and 2008 The Vertebral Column and Thorax Sternum Manubrium – bone that is trapezoidal in shape, makes up the superior aspect of the sternum. Jugular notch – concave notches on either side of the superior aspect of the manubrium, for articulation with the clavicles. Corpus or body – flat, rectangular bone making up the major portion of the sternum. The lateral aspects contain the notches for the true ribs, called the costal notches. Xiphoid process – variably shaped bone found at the inferior aspect of the corpus. Process may fuse late in life to the corpus. Clavicle Sternal end – rounded end, articulates with manubrium. Acromial end – flat end, articulates with scapula. Conoid tuberosity – muscle attachment located on the inferior aspect of the shaft, pointing posteriorly. Ribs Scapulae Head Ventral surface Neck Dorsal surface Tubercle Spine Shaft Coracoid process Costal groove Acromion Glenoid fossa Axillary margin Medial angle Vertebral margin Manubrium. Left anterior aspect, right posterior aspect. Sternum and Xyphoid Process. Left anterior aspect, right posterior aspect. Clavicle. Left side. Top superior and bottom inferior. First Rib. Left superior and right inferior. Second Rib. Left inferior and right superior. Typical Rib. Left inferior and right superior. Eleventh Rib. Left posterior view and left superior view. Twelfth Rib. Top shows anterior view and bottom shows posterior view. Scapula. Left side. Top anterior and bottom posterior. Scapula. Top lateral and bottom superior. Clavicle Sternum Scapula Ribs Vertebrae Body - Development of the vertebrae can be used in aging of individuals. -
Tracheal Perforation in a Neonate: a Devastating
Letters to Editor Tracheal perforation in a size of endotracheal tube, cuff overinflation, cough and vigorous movements of head and neck.[2,3] neonate: A devastating Neonatal tracheal injury is ascribed to factors like complication following traumatic traumatic delivery, weak trachea, congenital tracheal endotracheal intubation stenosis, ring agenesis, metal stylets, rigid endotracheal tube, excessive external laryngeal pressure and [1,4,5] Sir, prolonged ventilation. Tracheal injury in neonates following endotracheal In our case, rigorous attempts at intubation along with intubation represents an uncommon complication excessive hyperextension of head and neck due to altered rarely described in literature but carries high anatomy are likely to have contributed to tracheal injury. morbidity and a mortality rate of 70%.[1] We describe Multiple attempts at intubation are known to result in a [4] a case of neonatal tracheal perforation following false tract and are related to anterior tracheal lesions. multiple attempts at endotracheal intubation due to an Incidentally, our case was an undiagnosed Pierre unanticipated difficulty in an emergency situation in Robins Sequence. A small receding mandible, tongue an undiagnosed case of Pierre Robin Sequence. immobility and cleft palate are identified as independent factors for difficult airway with a risk of upper airway A 4-week-old female baby presented to the emergency obstruction, difficult mask holding, difficult intubation, department with respiratory difficulty. In view of severe leak through the cleft resulting in inadequate ventilation respiratory distress and desaturation (SpO2- 60%) a as well as passage of the endotracheal tube into the decision was made to provide ventilatory support to cleft.[6] Successful airway management in such situation the neonate. -
Spinal Deformity Study Group
Spinal Deformity Study Group Editors in Chief Radiographic Michael F. O’Brien, MD Timothy R. Kuklo, MD Kathy M. Blanke, RN Measurement Lawrence G. Lenke, MD Manual B T2 T5 T2–T12 CSVL T5–T12 +X° -X +X° C7PL T12 L2 A S1 ©2008 Medtronic Sofamor Danek USA, Inc. – 0 + Radiographic Measurement Manual Editors in Chief Michael F. O’Brien, MD Timothy R. Kuklo, MD Kathy M. Blanke, RN Lawrence G. Lenke, MD Section Editors Keith H. Bridwell, MD Kathy M. Blanke, RN Christopher L. Hamill, MD William C. Horton, MD Timothy R. Kuklo, MD Hubert B. Labelle, MD Lawrence G. Lenke, MD Michael F. O’Brien, MD David W. Polly Jr, MD B. Stephens Richards III, MD Pierre Roussouly, MD James O. Sanders, MD ©2008 Medtronic Sofamor Danek USA, Inc. Acknowledgements Radiographic Measurement Manual The radiographic measurement manual has been developed to present standardized techniques for radiographic measurement. In addition, this manual will serve as a complimentary guide for the Spinal Deformity Study Group’s radiographic measurement software. Special thanks to the following members of the Spinal Deformity Study Group in the development of this manual. Sigurd Berven, MD Hubert B. Labelle, MD Randal Betz, MD Lawrence G. Lenke, MD Fabien D. Bitan, MD Thomas G. Lowe, MD John T. Braun, MD John P. Lubicky, MD Keith H. Bridwell, MD Steven M. Mardjetko, MD Courtney W. Brown, MD Richard E. McCarthy, MD Daniel H. Chopin, MD Andrew A. Merola, MD Edgar G. Dawson, MD Michael Neuwirth, MD Christopher DeWald, MD Peter O. Newton, MD Mohammad Diab, MD Michael F. -
Lordosis, Kyphosis, and Scoliosis
SPINAL CURVATURES: LORDOSIS, KYPHOSIS, AND SCOLIOSIS The human spine normally curves to aid in stability or balance and to assist in absorbing shock during movement. These gentle curves can be seen from the side or lateral view of the spine. When viewed from the back, the spine should run straight down the middle of the back. When there are abnormalities or changes in the natural spinal curvature, these abnormalities are named with the following conditions and include the following symptoms. LORDOSIS Some lordosis is normal in the lower portion or, lumbar section, of the human spine. A decreased or exaggerated amount of lordosis that is causing spinal instability is a condition that may affect some patients. Symptoms of Lordosis include: ● Appearance of sway back where the lower back region has a pronounced curve and looks hollow with a pronounced buttock area ● Difficulty with movement in certain directions ● Low back pain KYPHOSIS This condition is diagnosed when the patient has a rounded upper back and the spine is bent over or curved more than 50 degrees. Symptoms of Kyphosis include: ● Curved or hunched upper back ● Patient’s head that leans forward ● May have upper back pain ● Experiences upper back discomfort after movement or exercise SCOLIOSIS The most common of the three curvatures. This condition is diagnosed when the spine looks like a “s” or “c” from the back. The spine is not straight up and down but has a curve or two running side-to-side. Sagittal Balance Definition • Sagittal= front-to-back direction (sagittal plane) • Imbalance= Lack of harmony or balance Etiology • Excessive lordosis (backwards lean) or kyphosis (forward lean) • Traumatic injury • Previous spinal fusion that disrupted sagittal balance Effects • Low back pain • Difficulty walking • Inability to look straight ahead when upright The most ergonomic and natural posture is to maintain neutral balance, with the head positioned over the shoulders and pelvis. -
5. Vertebral Column
5. Vertebral Column. Human beings belong to a vast group animals, the vertebrates. In simple terms we say that vertebrates are animals with a backbone. This statement barely touches the surface of the issue. Vertebrates are animals with a bony internal skeleton. Besides, all vertebrates have a fundamental common body plan. The central nervous system is closer to the back than it is to the belly, the digestive tube in the middle and the heart is ventral. The body is made of many segments (slices) built to a common plan, but specialised in different regions of the body. A “coelomic cavity” with its own special plan is seen in the trunk region and has a characteristic relationship with the organs in the trunk. This is by no means a complete list of vertebrate characteristics. Moreover, some of these features may be shared by other animal groups in a different manner. Such a study is beyond the scope of this unit. Vertebrates belong to an even wider group of animals, chordates. It may be difficult to imagine that we human beings are in fact related to some the earlier chordates! However, we do share, at least during embryonic development, an important anatomical structure with all chordates. This structure is the notochord. The notochord is the first stiff, internal support that appeared during the evolutionary story. As we have seen in early embryology, it also defines the axis of the body. The vertebral column evolved around the notochord and the neural tube, and we see a reflection of this fact during our embryonic development. -
Surgery for Lumbar Radiculopathy/ Sciatica Final Evidence Report
Surgery for Lumbar Radiculopathy/ Sciatica Final evidence report April 13, 2018 Health Technology Assessment Program (HTA) Washington State Health Care Authority PO Box 42712 Olympia, WA 98504-2712 (360) 725-5126 www.hca.wa.gov/hta [email protected] Prepared by: RTI International–University of North Carolina Evidence-based Practice Center Research Triangle Park, NC 27709 www.rti.org This evidence report is based on research conducted by the RTI-UNC Evidence-based Practice Center through a contract between RTI International and the State of Washington Health Care Authority (HCA). The findings and conclusions in this document are those of the authors, who are responsible for its contents. The findings and conclusions do not represent the views of the Washington HCA and no statement in this report should be construed as an official position of Washington HCA. The information in this report is intended to help the State of Washington’s independent Health Technology Clinical Committee make well-informed coverage determinations. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information (i.e., in the context of available resources and circumstances presented by individual patients). This document is in the public domain and may be used and reprinted without permission except those copyrighted materials that are clearly noted in the document. Further reproduction of those copyrighted materials is prohibited without the specific permission of copyright holders. -
Anatomic Mapping of Lumbar Nerve Roots During a Direct Lateral Transpsoas Approach to the Spine a Cadaveric Study
SPINE Volume 36, Number 11, pp E687–E691 ©2011, Lippincott Williams & Wilkins ANATOMY Anatomic Mapping of Lumbar Nerve Roots During a Direct Lateral Transpsoas Approach to the Spine A Cadaveric Study Kelley Banagan , MD, Daniel Gelb , MD, Kornelis Poelstra , MD, PhD, and Steven Ludwig , MD longitudinal ligament at the level of the disc to the sympathetic chain Study Design. Cadaveric study. averaged 9.25 mm. The nerve roots and genitofemoral nerve were Objective. Identifying anatomic structures at risk for injury during placed at risk in all dissections in which the approach was recreated. direct lateral transpsoas approach to the spine. Damage secondary to K-wire placement occurred in 25% of cases Summary of Background Data. Direct lateral transpsoas at L3–L4 and L4–L5; in one case, L4 nerve root was pierced, and approach is a novel technique that has been described for anterior in another, genitofemoral nerve was pierced. K-wire was posterior lumbar interbody fusion. Potential risks include damage to to the nerve roots in 25% of cases at L3–L4 and in 50% of cases genitofemoral nerve and lumbar plexus, which are not well visualized at L4–L5. The lumbar plexus was placed under tension because of during small retroperitoneal exposure. Previous cadaveric studies did sequential dilator placement. not evaluate the direct lateral transpsoas approach, and considering Conclusion. On the basis of our results, there is no zone of absolute the approach being used in clinical practice, the current study was safety when using the direct lateral transpsoas approach. The potential undertaken in an effort to identify the structures at risk during direct for nerve injury exists when using this approach, and consequently, we lateral transpsoas approach. -
Megalencephaly and Macrocephaly
277 Megalencephaly and Macrocephaly KellenD.Winden,MD,PhD1 Christopher J. Yuskaitis, MD, PhD1 Annapurna Poduri, MD, MPH2 1 Department of Neurology, Boston Children’s Hospital, Boston, Address for correspondence Annapurna Poduri, Epilepsy Genetics Massachusetts Program, Division of Epilepsy and Clinical Electrophysiology, 2 Epilepsy Genetics Program, Division of Epilepsy and Clinical Department of Neurology, Fegan 9, Boston Children’s Hospital, 300 Electrophysiology, Department of Neurology, Boston Children’s Longwood Avenue, Boston, MA 02115 Hospital, Boston, Massachusetts (e-mail: [email protected]). Semin Neurol 2015;35:277–287. Abstract Megalencephaly is a developmental disorder characterized by brain overgrowth secondary to increased size and/or numbers of neurons and glia. These disorders can be divided into metabolic and developmental categories based on their molecular etiologies. Metabolic megalencephalies are mostly caused by genetic defects in cellular metabolism, whereas developmental megalencephalies have recently been shown to be caused by alterations in signaling pathways that regulate neuronal replication, growth, and migration. These disorders often lead to epilepsy, developmental disabilities, and Keywords behavioral problems; specific disorders have associations with overgrowth or abnor- ► megalencephaly malities in other tissues. The molecular underpinnings of many of these disorders are ► hemimegalencephaly now understood, providing insight into how dysregulation of critical pathways leads to ► -
Study Guide Medical Terminology by Thea Liza Batan About the Author
Study Guide Medical Terminology By Thea Liza Batan About the Author Thea Liza Batan earned a Master of Science in Nursing Administration in 2007 from Xavier University in Cincinnati, Ohio. She has worked as a staff nurse, nurse instructor, and level department head. She currently works as a simulation coordinator and a free- lance writer specializing in nursing and healthcare. All terms mentioned in this text that are known to be trademarks or service marks have been appropriately capitalized. Use of a term in this text shouldn’t be regarded as affecting the validity of any trademark or service mark. Copyright © 2017 by Penn Foster, Inc. All rights reserved. No part of the material protected by this copyright may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the copyright owner. Requests for permission to make copies of any part of the work should be mailed to Copyright Permissions, Penn Foster, 925 Oak Street, Scranton, Pennsylvania 18515. Printed in the United States of America CONTENTS INSTRUCTIONS 1 READING ASSIGNMENTS 3 LESSON 1: THE FUNDAMENTALS OF MEDICAL TERMINOLOGY 5 LESSON 2: DIAGNOSIS, INTERVENTION, AND HUMAN BODY TERMS 28 LESSON 3: MUSCULOSKELETAL, CIRCULATORY, AND RESPIRATORY SYSTEM TERMS 44 LESSON 4: DIGESTIVE, URINARY, AND REPRODUCTIVE SYSTEM TERMS 69 LESSON 5: INTEGUMENTARY, NERVOUS, AND ENDOCRINE S YSTEM TERMS 96 SELF-CHECK ANSWERS 134 © PENN FOSTER, INC. 2017 MEDICAL TERMINOLOGY PAGE III Contents INSTRUCTIONS INTRODUCTION Welcome to your course on medical terminology. You’re taking this course because you’re most likely interested in pursuing a health and science career, which entails proficiencyincommunicatingwithhealthcareprofessionalssuchasphysicians,nurses, or dentists. -
SCOLIOSIS: What Is New and True? Natural History, Screening/Evaluation and Treatment
SCOLIOSIS: what is new and true? Natural history, screening/evaluation and treatment Kathleen Moen MD Swedish Pediatric Specialty Update January 24, 2020 OBJECTIVES • 1) review of entity adolescent idiopathic scoliosis • 2) review the natural history of treated and untreated disease • 3) review screening recommendations and delineating patients who warrant referral • 4) review of treatment modalities Scoliosis • Definition: a lateral spinal curvature measuring at least 10 degrees on xray • Complex 3dimensional spinal deformity Adolescent Idiopathic Scoliosis • AIS: Scoliosis most often develops and progresses during the most rapid times of growth, typically between ages 10 ‐15 years. • NOT infantile or juvenile scoliosis which have different natural history profiles • NOT congenital spinal deformities, neuromuscular scoliosis or spinal dysraphism Adolescent Idiopathic Scoliosis • Classic Teaching – Small curves are common – Progression occurs during most rapid times of growth – Female predominance – Big curves get bigger – Etiology unclear: familial predisposition, and? – Idiopathic scoliosis not typically painful Adolescent Idiopathic Scoliosis • Mild scoliosis curves are common, affecting 2‐3% of the adolescent population, males and females equally • Less than 0.1% of adolescents have curves greater than 40 degrees. • Ratio of females to males 10:1 Cobb Angle Female:Male Prevalence >10 1.4‐2 :1 2 ‐ 3 % >20 5:1 .3 ‐ .5 % >30 10:1 .1 ‐ .3 % >40 10:1 <0.1% Weinstein, SL Adolescent Idiopathic Scoliosis, Prevalence and Natural History. Instructional -
Macrocephaly Information Sheet 6-13-19
Next Generation Sequencing Panel for Macrocephaly Clinical Features: Macrocephaly refers to an abnormally large head, OFC greater than 98th percentile, inclusive of the scalp, cranial bone and intracranial contents. Megalencephaly, brain weight/volume ratio greater than 98th percentile, results from true enlargement of the brain parenchyma [1]. Megalencephaly is typically accompanied by macrocephaly, however macrocephaly can occur in the absence of megalencephaly [2]. Both macrocephaly and megalencephaly can been seen as isolated clinical findings as well as clinical features of a mutli-systemic syndromic diagnosis. Our Macrocephaly Panel includes analysis of the 36 genes listed below. Macrocephaly Sequencing Panel ASXL2 GLI3 MTOR PPP2R5D TCF20 BRWD3 GPC3 NFIA PTEN TBC1D7 CHD4 HEPACAM NFIX RAB39B UPF3B CHD8 HERC1 NONO RIN2 ZBTB20 CUL4B KPTN NSD1 RNF125 DNMT3A MED12 OFD1 RNF135 EED MITF PIGA SEC23B EZH2 MLC1 PPP1CB SETD2 Gene Clinical Features Details ASXL2 Shashi-Pena Shashi et al. (2016) found that six patients with developmental delay, syndrome macrocephaly, and dysmorphic features were found to have de novo truncating variants in ASXL2 [3]. Distinguishing features were macrocephaly, absence of growth retardation, and variability in the degree of intellectual disabilities The phenotype also consisted of prominent eyes, arched eyebrows, hypertelorism, a glabellar nevus flammeus, neonatal feeding difficulties and hypotonia. BRWD3 X-linked intellectual Truncating mutations in the BRWD3 gene have been described in males with disability nonsyndromic intellectual disability and macrocephaly [4]. Other features include a prominent forehead and large cupped ears. CHD4 Sifrim-Hitz-Weiss Weiss et al., 2016, identified five individuals with de novo missense variants in the syndrome CHD4 gene with intellectual disabilities and distinctive facial dysmorphisms [5]. -
Spondylolysis and Spondylolisthesis in Children and Adolescents: I
Spondylolysis and Spondylolisthesis in Children and Adolescents: I. Diagnosis, Natural History, and Nonsurgical Management Ralph Cavalier, MD Abstract Martin J. Herman, MD Spondylolysis and spondylolisthesis are often diagnosed in children Emilie V. Cheung, MD presenting with low back pain. Spondylolysis refers to a defect of Peter D. Pizzutillo, MD the vertebral pars interarticularis. Spondylolisthesis is the forward translation of one vertebral segment over the one beneath it. Isth- Dr. Cavalier is Attending Orthopaedic mic spondylolysis, isthmic spondylolisthesis, and stress reactions Surgeon, Summit Sports Medicine and involving the pars interarticularis are the most common forms seen Orthopaedic Surgery, Brunswick, GA. Dr. Herman is Associate Professor, in children. Typical presentation is characterized by a history of Department of Orthopaedic Surgery, activity-related low back pain and the presence of painful spinal Drexel University College of Medicine, mobility and hamstring tightness without radiculopathy. Plain ra- St. Christopher’s Hospital for Children, Philadelphia, PA. Dr. Cheung is Fellow, diography, computed tomography, and single-photon emission Department of Orthopaedic Surgery, computed tomography are useful for establishing the diagnosis. Mayo Clinic, Rochester, MN. Dr. Symptomatic stress reactions of the pars interarticularis or adjacent Pizzutillo is Professor, Department of vertebral structures are best treated with immobilization of the Orthopaedic Surgery, Drexel University College of Medicine, St. Christopher’s spine and activity restriction. Spondylolysis often responds to brief Hospital for Children. periods of activity restriction, immobilization, and physiotherapy. None of the following authors or the Low-grade spondylolisthesis (≤50% translation) is treated similarly. departments with which they are The less common dysplastic spondylolisthesis with intact posterior affiliated has received anything of value elements requires greater caution.