Helicobacter Pullorum As a Cause of Enterohepatic
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Kongre Kitabı
Book of Abstracts International VETistanbul Group Congress 2014 28-30 April, 2014 Istanbul, Turkey Book of Abstracts www.vetistanbul2014.org International VETistanbul Group Congress 2014 28-30 April 2014 International VETistanbul Group Congress 2014 28-30 April, 2014 Istanbul, Turkey Organizing Committee Prof. Dr. Halil GÜNEŞ, Chair Prof. Dr. Bülent EKİZ Prof. Dr. Ali AYDIN Assoc. Prof. Dr. Serkan İKİZ Assoc. Prof. Dr. Hasret DEMİRCAN YARDİBİ Assoc. Prof. Dr. Gülsün PAZVANT Scientific Committee* Prof. Dr. Kemal AK, Turkey Prof. Dr. Anatoliy ALEXANDROVICH STEKOLNIKOV, Russia Prof. Dr. Bogdan AMINKOV, Bulgaria Prof. Dr. Geno ATASANOV ANGELOV, Bulgaria Prof. Dr. Hajrudin BESIROVIC, Bosnia and Herzegovina Prof. Dr. Nihad FEJZIC, Bosnia and Herzegovina Assoc. Prof. Dr. Plamen GEORGIEV, Bulgaria Prof. Dr. Zehra HAJRULAI MUSLIU, Macedonia Assoc. Prof. Dr. Afrim HAMIDI, Kosovo Prof. Dr. Telman ISKENDEROV, Azerbaijan Prof. Dr. Larisa KARPENKO, Russia Prof. Dr. Ismail KIRSAN, Turkey Prof. Dr. Mihni LYUTSKANOV, Bulgaria Assoc. Prof. Dr. Avni ROBAJ, Kosovo Prof. Dr. Velimir STOJKOVSKI, Macedonia Prof. Dr. Semsir VELIYEV, Azerbaijan *Alphabetically listed by the according to the family name Scientific Secreteria Prof. Dr. Bülent EKİZ, Turkey Dr. Karlo MURATOĞLU, Turkey International VETistanbul Group Congress 2014, 28-30 April, Istanbul, Turkey IV International VETistanbul Group Congress 2014 28-30 April 2014 Dear Respectable Colleagues and Guests, First of all, I greet you all with my heart. Also, I would like to thank you for taking place on our side due to the contribution given to the establishment of VETistanbul Group. Known as, VETistanbul Group was established, under the coordination of Istanbul University, with joint decision of Veterinary Faculty of the University of Sarajevo, Saint Petersburg State Academy of Veterinary Medicine, Stara Zagora Trakia University, Ss. -
WO 2018/064165 A2 (.Pdf)
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2018/064165 A2 05 April 2018 (05.04.2018) W !P O PCT (51) International Patent Classification: Published: A61K 35/74 (20 15.0 1) C12N 1/21 (2006 .01) — without international search report and to be republished (21) International Application Number: upon receipt of that report (Rule 48.2(g)) PCT/US2017/053717 — with sequence listing part of description (Rule 5.2(a)) (22) International Filing Date: 27 September 2017 (27.09.2017) (25) Filing Language: English (26) Publication Langi English (30) Priority Data: 62/400,372 27 September 2016 (27.09.2016) US 62/508,885 19 May 2017 (19.05.2017) US 62/557,566 12 September 2017 (12.09.2017) US (71) Applicant: BOARD OF REGENTS, THE UNIVERSI¬ TY OF TEXAS SYSTEM [US/US]; 210 West 7th St., Austin, TX 78701 (US). (72) Inventors: WARGO, Jennifer; 1814 Bissonnet St., Hous ton, TX 77005 (US). GOPALAKRISHNAN, Vanch- eswaran; 7900 Cambridge, Apt. 10-lb, Houston, TX 77054 (US). (74) Agent: BYRD, Marshall, P.; Parker Highlander PLLC, 1120 S. Capital Of Texas Highway, Bldg. One, Suite 200, Austin, TX 78746 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. -
Assessment of Host Genetics and Environmental Factors in Shaping the Gut Microbiota
Assessment of host genetics and environmental factors in shaping the gut microbiota Von der Fakultät für Lebenswissenschaften der Technischen Universität Carolo-Wilhelmina zu Braunschweig zur Erlangung des Grades eines Doktors der Naturwissenschaften (Dr. rer. nat.) genehmigte D i s s e r t a t i o n von Eric Juan Carlos Gálvez Bobadilla aus Fusagasugá / Kolumbien 1. Referentin: Professorin Dr. Petra Dersch 2. Referent: Professor Dr. Karsten Hiller eingereicht am: 01.10.2018 mündliche Prüfung (Disputation) am: 12.12.2018 Druckjahr 2019 Vorveröffentlichungen der Dissertation Teilergebnisse aus dieser Arbeit wurden mit Genehmigung der Fakultät für Lebenswissenschaften, vertreten durch die Mentorin der Arbeit, in folgenden Beiträgen vorab veröffentlicht: Publikationen Gálvez EJC*, Iljazovic A, Gronow A, Flavell RA, Strowig T**. Shaping of intestinal microbiota in Nlrp6 and Rag2 deficient mice depends on community structure. Cell Rep. (2017). * First author, **Corresponding author Tagungsbeiträge Eric J.C Gálvez and Till Strowig: Low Complexity Microbiota mice (LCM) A stable and defined gut microbiota to study host-microbial interactions (Oral Presentation). 7th Seeon Conference on „Microbiota, Probiota and Host“, 04-06 July 2014. Kloster Seeon, Germany. Eric J.C Gálvez and Till Strowig: Composition and functional dynamics of novel gut commensal species of Prevotella (Oral Presentation). EMBO|FEBS Lecture course: The new microbiology, 24 August – 1 September 2016. Spetses, Greece. Acknowledgments I would like to express my deep gratitude to my mentor, Dr. Till Strowig, for his constant support during the past years. Thank you for your patient guidance, enthusiastic encouragement and all the great advice without which this thesis would have not been possible. -
Genomics of Helicobacter Species 91
Genomics of Helicobacter Species 91 6 Genomics of Helicobacter Species Zhongming Ge and David B. Schauer Summary Helicobacter pylori was the first bacterial species to have the genome of two independent strains completely sequenced. Infection with this pathogen, which may be the most frequent bacterial infec- tion of humanity, causes peptic ulcer disease and gastric cancer. Other Helicobacter species are emerging as causes of infection, inflammation, and cancer in the intestine, liver, and biliary tract, although the true prevalence of these enterohepatic Helicobacter species in humans is not yet known. The murine pathogen Helicobacter hepaticus was the first enterohepatic Helicobacter species to have its genome completely sequenced. Here, we consider functional genomics of the genus Helico- bacter, the comparative genomics of the genus Helicobacter, and the related genera Campylobacter and Wolinella. Key Words: Cytotoxin-associated gene; H-Proteobacteria; gastric cancer; genomic evolution; genomic island; hepatobiliary; peptic ulcer disease; type IV secretion system. 1. Introduction The genus Helicobacter belongs to the family Helicobacteriaceae, order Campylo- bacterales, and class H-Proteobacteria, which is also known as the H subdivision of the phylum Proteobacteria. The H-Proteobacteria comprise of a relatively small and recently recognized line of descent within this extremely large and phenotypically diverse phy- lum. Other genera that colonize and/or infect humans and animals include Campylobac- ter, Arcobacter, and Wolinella. These organisms are all microaerophilic, chemoorgano- trophic, nonsaccharolytic, spiral shaped or curved, and motile with a corkscrew-like motion by means of polar flagella. Increasingly, free living H-Proteobacteria are being recognized in a wide range of environmental niches, including seawater, marine sedi- ments, deep-sea hydrothermal vents, and even as symbionts of shrimp and tubeworms in these environments. -
Supplemental Material S1.Pdf
Phylogeny of Selenophosphate synthetases (SPS) Supplementary Material S1 ! SelD in prokaryotes! ! ! SelD gene finding in sequenced prokaryotes! We downloaded a total of 8263 prokaryotic genomes from NCBI (see Supplementary Material S7). We scanned them with the program selenoprofiles (Mariotti 2010, http:// big.crg.cat/services/selenoprofiles) using two SPS-family profiles, one prokaryotic (seld) and one mixed eukaryotic-prokaryotic (SPS). Selenoprofiles removes overlapping predictions from different profiles, keeping only the prediction from the profile that seems closer to the candidate sequence. As expected, the great majority of output predictions in prokaryotic genomes were from the seld profile. We will refer to the prokaryotic SPS/SelD !genes as SelD, following the most common nomenclature in literature.! To be able to inspect results by hand, and also to focus on good-quality genomes, we considered a reduced set of species. We took the prok_reference_genomes.txt list from ftp://ftp.ncbi.nlm.nih.gov/genomes/GENOME_REPORTS/, which NCBI claims to be a "small curated subset of really good and scientifically important prokaryotic genomes". We named this the prokaryotic reference set (223 species - see Supplementary Material S8). We manually curated most of the analysis in this set, while we kept automatized the !analysis on the full set.! We detected SelD proteins in 58 genomes (26.0%) in the prokaryotic reference set (figure 1 in main paper), which become 2805 (33.9%) when considering the prokaryotic full set (figure SM1.1). The difference in proportion between the two sets is due largely to the presence of genomes of very close strains in the full set, which we consider redundant. -
The Year in Helicobacter 2020
EDITOR: David Y. Graham, M.D. The Year in Helicobacter 2020 Guest Editors: Francis Mégraud & Peter Malfertheiner Online only from 2011 The Year in Helicobacter XXXIIIrd Internaঞ onal Workshop on Helicobacter & Microbiota in Infl ammaঞ on & Cancer Virtual Conference September 12, 2020 Guest editors: Francis Mégraud & Peter Malfertheiner This publicaঞ on has been supported by European Helicobacter and Microbiota Study Group Helicobacter VOLUME 25 SUPPLEMENT 1 SEPTEMBER 2020 CONTENTS REVIEW ARTICLES e12734 Review: Epidemiology of Helicobacter pylori Linda Mezmale, Luiz Gonzaga Coelho, Dmitry Bordin and Marcis Leja e12735 Review: Diagnosis of Helicobacter pylori infecঞ on Gauri Godbole, Francis Mégraud and Emilie Bessède e12736 Review: Pathogenesis of Helicobacter pylori infecঞ on Milica Denic, Elie e Touaࢼ and Hilde De Reuse e12737 Review - Helicobacter, infl ammaঞ on, immunology and vaccines Karen Robinson and Philippe Lehours e12738 Review - Helicobacter pylori and non-malignant upper gastro-intesঞ nal diseases Chrisࢼ an Schulz and Juozas Kupcˇinskas e12739 Review: Gastric cancer: Basic aspects Carlos Resende, Carla Pereira Gomes and Jose Carlos Machado e12740 Review: Prevenঞ on and management of gastric cancer Marino Venerito, Alexander C. Ford, Theodoros Rokkas and Peter Malfertheiner e12741 Review: Extragastric diseases and Helicobacter pylori Rinaldo Pellicano, Gianluca Ianiro, Sharmila Fagoonee, Carlo R. Se anni and Antonio Gasbarrini e12742 Review: Helicobacter pylori infecঞ on in children Ji-Hyun Seo, Kristen Bortolin and Nicola L. -
Helicobacter Spp. — Food- Or Waterborne Pathogens?
FRI FOOD SAFETY REVIEWS Helicobacter spp. — Food- or Waterborne Pathogens? M. Ellin Doyle Food Research Institute University of Wisconsin–Madison Madison WI 53706 Contents34B Introduction....................................................................................................................................1 Virulence Factors ...........................................................................................................................2 Associated Diseases .......................................................................................................................2 Gastrointestinal Disease .........................................................................................................2 Neurological Disease..............................................................................................................3 Other Diseases........................................................................................................................4 Epidemiology.................................................................................................................................4 Prevalence..............................................................................................................................4 Transmission ..........................................................................................................................4 Summary .......................................................................................................................................5 -
Mouse Models for Human Intestinal Microbiota Research: a Critical Evaluation
Cell. Mol. Life Sci. (2018) 75:149–160 https://doi.org/10.1007/s00018-017-2693-8 Cellular and Molecular LifeSciences MULTI-AUTHOR REVIEW Mouse models for human intestinal microbiota research: a critical evaluation Floor Hugenholtz1,3 · Willem M. de Vos1,2 Received: 25 September 2017 / Accepted: 29 September 2017 / Published online: 9 November 2017 © The Author(s) 2017. This article is an open access publication Abstract Since the early days of the intestinal microbi- data. This may afect the reproducibility of mouse micro- ota research, mouse models have been used frequently to biota studies and their conclusions. Hence, future studies study the interaction of microbes with their host. However, should take these into account to truly show the efect of to translate the knowledge gained from mouse studies to diet, genotype or environmental factors on the microbial a human situation, the major spatio-temporal similarities composition. and diferences between intestinal microbiota in mice and humans need to be considered. This is done here with spe- Keywords Microbiome · Metagenome · Phylogeny · cifc attention for the comparative physiology of the intes- Murine models · Reproducibility · Diet tinal tract, the efect of dietary patterns and diferences in genetics. Detailed phylogenetic and metagenomic analysis showed that while many common genera are found in the Introduction human and murine intestine, these difer strongly in abun- dance and in total only 4% of the bacterial genes are found In adult life, a healthy human may harbor several hundreds to share considerable identity. Moreover, a large variety of diferent microbial species in their intestine, which col- of murine strains is available yet most of the microbiota lectively encode more than 100-fold more non-redundant research is performed in wild-type, inbred strains and their genes than there are in the human genome [1–3]. -
Comparison of the Culture and PCR Methods to Determine The
Archive of SID Comparison of the Culture and PCR Methods to Determine the Prevalence and Antibiotic Resistance of Helicobacter pullorum Isolated from Chicken Thigh Samples in Semnan, Iran a b * c d Ashkan Jebellijavan | Seyed Hesamodin Emadi Chashmi | Hamid Staji | Hossein Akhlaghi a. Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran. b. Department of Clinical Science, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran. c. Department of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran. d. DVM Student of Veterinary Medicine (D. V. M), Faculty of Veterinary Medicine, Semnan University, Semnan, Iran. *Corresponding author: Department of Clinical Science, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran. Postal code: 3513119111. E-mail address: [email protected] ARTICLE INFO ABSTRACT Article type: Background: Helicobacter pullorum is among the most frequently reported pathogens Original article in poultry. The present study aimed to compare the culture and polymerase chain reaction (PCR) methods to assess the prevalence of H. pullorum isolated from chicken Article history: tight samples in Semnan, Iran. The antibiotic resistance pattern of the H. pullorum Received: 4 October 2020 isolates was also determined for the first time in Iran. Revised: 10 December 2020 Accepted: 29 December 2020 Methods: In total, 50 chicken thigh samples were collected from the local retail markets in Semnan city during January-September 2019. The samples were examined using the culture method and biochemical tests, and the final confirmation was based DOI: 10.29252/jhehp.6.4.3 on PCR with the 16S rRNA gene. In addition, antibiotic resistance test was performed using the disc-diffusion method. -
Microbial and Mineralogical Characterizations of Soils Collected from the Deep Biosphere of the Former Homestake Gold Mine, South Dakota
University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln US Department of Energy Publications U.S. Department of Energy 2010 Microbial and Mineralogical Characterizations of Soils Collected from the Deep Biosphere of the Former Homestake Gold Mine, South Dakota Gurdeep Rastogi South Dakota School of Mines and Technology Shariff Osman Lawrence Berkeley National Laboratory Ravi K. Kukkadapu Pacific Northwest National Laboratory, [email protected] Mark Engelhard Pacific Northwest National Laboratory Parag A. Vaishampayan California Institute of Technology See next page for additional authors Follow this and additional works at: https://digitalcommons.unl.edu/usdoepub Part of the Bioresource and Agricultural Engineering Commons Rastogi, Gurdeep; Osman, Shariff; Kukkadapu, Ravi K.; Engelhard, Mark; Vaishampayan, Parag A.; Andersen, Gary L.; and Sani, Rajesh K., "Microbial and Mineralogical Characterizations of Soils Collected from the Deep Biosphere of the Former Homestake Gold Mine, South Dakota" (2010). US Department of Energy Publications. 170. https://digitalcommons.unl.edu/usdoepub/170 This Article is brought to you for free and open access by the U.S. Department of Energy at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in US Department of Energy Publications by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. Authors Gurdeep Rastogi, Shariff Osman, Ravi K. Kukkadapu, Mark Engelhard, Parag A. Vaishampayan, Gary L. Andersen, and Rajesh K. Sani This article is available at DigitalCommons@University of Nebraska - Lincoln: https://digitalcommons.unl.edu/ usdoepub/170 Microb Ecol (2010) 60:539–550 DOI 10.1007/s00248-010-9657-y SOIL MICROBIOLOGY Microbial and Mineralogical Characterizations of Soils Collected from the Deep Biosphere of the Former Homestake Gold Mine, South Dakota Gurdeep Rastogi & Shariff Osman & Ravi Kukkadapu & Mark Engelhard & Parag A. -
Helicobacter Typhlonius and Helicobacter Rodentium
Comparative Medicine Vol 58, No 6 Copyright 2008 December 2008 by the American Association for Laboratory Animal Science Pages 534–541 Helicobacter typhlonius and Helicobacter rodentium Differentially Affect the Severity of Colon Inflammation and Inflammation-Associated Neoplasia in IL10-Deficient Mice Maciej Chichlowski,1 Julie M Sharp,2 Deborah A Vanderford,2 Matthew H Myles,3 and Laura P Hale1,* Infection with Helicobacter species is endemic in many animal facilities and may alter the penetrance of inflammatory bowel disease (IBD) phenotypes. However, little is known about the relative pathogenicity of H. typhlonius, H. rodentium, and combined infection in IBD models. We infected adult and neonatal IL10−/− mice with H. typhlonius, H. rodentium, or both bacteria. The sever- ity of IBD and incidence of inflammation-associated colonic neoplasia were assessed in the presence and absence of antiHelico- bacter therapy. Infected IL10−/− mice developed IBD with severity of noninfected (minimal to no inflammation)< H. rodentium < H. typhlonius < mixed H. rodentium + H. typhlonius (severe inflammation). Inflammation-associated colonic neoplasia was common in infected mice and its incidence correlated with IBD severity. Combined treatment with amoxicillin, clarithromycin, metronidazole, and omeprazole eradicated Helicobacter in infected mice and ameliorated established IBD in both infected and noninfected mice. Infection of IL10−/− mice with H. rodentium, H. typhlonius, or both organisms can trigger development of severe IBD that eventually leads to colonic neoplasia. The high incidence and multiplicity of neoplastic lesions in infected mice make this model well-suited for future research related to the development and chemoprevention of inflammation-associated colon cancer. The similar antiin- flammatory effect of antibiotic therapy inHelicobacter -infected and -noninfected IL10−/− mice with colitis indicates that unidentified microbiota in addition to Helicobacter drive the inflammatory process in this model. -
Lamellipodin-Deficient Mice: a Model of Rectal Carcinoma
Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Miller, Cassandra L.; Muthupalani, Sureshkumar; Shen, Zeli; Drees, Frauke; Ge, Zhongming; Feng, Yan; Chen, Xiaowei et al. “Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma.” Edited by Sergei Grivennikov. PLoS ONE 11, no. 4 (April 2016): e0152940 © 2016 Miller et al. As Published http://dx.doi.org/10.1371/journal.pone.0152940 Publisher Public Library of Science Version Final published version Citable link http://hdl.handle.net/1721.1/109443 Terms of Use Creative Commons Attribution Detailed Terms http://creativecommons.org/licenses/by/4.0/ RESEARCH ARTICLE Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma Cassandra L. Miller1¤, Sureshkumar Muthupalani1, Zeli Shen1, Frauke Drees2, Zhongming Ge1, Yan Feng1, Xiaowei Chen3, Guanyu Gong4, Karan K. Nagar3, Timothy C. Wang3, Frank B. Gertler2, James G. Fox1,4* 1 Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, United States of America, 2 David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States of America, 3 Division of Digestive and Liver Diseases, Columbia University, New York, NY, United States of America, 4 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States of America ¤ Current address: SNBL USA, Ltd., Everett, WA, United States of America a11111 * [email protected] Abstract During a survey of clinical rectal prolapse (RP) cases in the mouse population at MIT animal OPEN ACCESS research facilities, a high incidence of RP in the lamellipodin knock-out strain, C57BL/6- Raph1tm1Fbg (Lpd-/-) was documented.