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Chapter 2 ROLE of LYMPHOSCINTIGRAPHY for SELECTIVE SENTINEL LYMPHADENECTOMY
Chapter 2 ROLE OF LYMPHOSCINTIGRAPHY FOR SELECTIVE SENTINEL LYMPHADENECTOMY Roger F. Uren, Robert B. Howman-Giles, David Chung, John F. Thompson* Nuclear Medicine and Diagnostic Ultrasound, RPAH Medical Centre and Discipline oj Medicine, The University of Sydney, Sydney, NSW, Australia and The Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW and Discipline of Surgery*, The University of Sydney, Sydney, NSW, Australia Abstract: An essential prerequisite for a successful sentinel node biopsy (SNB) procedure is an accurate map of the pattern of lymphatic drainage from the primary tumor site. The role of lymphoscintigraphy(LS) in SNB is to provide such a map in each patient. This map should indicate not only the location of all sentinel nodes but also the number of SNs at each location. Such mapping can be achieved using 99mTc-labeled small particle radiocolloids, high- resolution collimators with minimal septal penetration, and imaging protocols that detect all SNs in every patient regardless of their location. This is especially important in melanoma patients, since high-quality LS can identify the actual lymphatic collecting vessels as they drain into each SN. The SN is not always found in the nearest node field and is best defined as "any lymph node receiving direct lymphatic drainage from a primary tumor site." Reliable clinical prediction of lymphatic drainage from the skin or breast is not possible. Patterns of lymphatic drainage from the skin are highly variable from patient to patient, even from the same area of the skin. Unexpected lymphatic drainage has been found from the skin of the back to SNs in the triangular intermuscular space and in some patients through the posterior body wall to SNs in the para-aortic, paravertebral, and retroperitoneal areas. -
Polythelia -Six Nipples in Amiddle Varun Arunagiri in the Accessory Nipples
Stanley Medical Journal CASE REPORT - GENERAL SURGERY Polythelia - Six Nipples in a middle aged woman Varun Arunagiri(1), Kothai Anbalagan(1) Abstract Vol 3 | Issue 2 | April - June | 2016 - June 2 | April 3 | Issue Vol Supernumerary nipples are more than two nipples which normally exist in humans. Polythelia or supernumerary nipple is a rare condition with higher prevalence in males than in females with the ratio of 1.7:1. The maximum reported number of nipples in a person with Polythelia is seven in a male. The usual presentation of Polythelia is with three nipples. Here is an image of Polythelia in a 40 year old female presenting with six nipples without lactation from the supernumer- ary nipples and any other anomalies. She has breast fed her two children. Key-words: Polythelia; Supernumerary Nipples; Mammary ridge; Kajava Classification; Clear cells of Toker. Key Messages: 1. Polythelia is a benign condition with chances of malignancy in the accessory nipples. 2. Constant follow-up is needed when the patient says lump in the region of accessory nipple. 3. Lactation during the pregnancy is common. INTRODUCTION: reported number of nipples in a person with Polythelia is seven in a male. The usual presentation of polythelia is with Polythelia is a congenital anomaly of the breast three nipples where in there are accessory nipples along the milk line Mammals have six to seven nipples, which are apart from the normal two nipples. Amazia, polymazia, common among canines and felines. It is rare to see humans Polythelia, athelia are few congenital anomalies of the nip- with more than three nipples. -
Vessels and Circulation
CARDIOVASCULAR SYSTEM OUTLINE 23.1 Anatomy of Blood Vessels 684 23.1a Blood Vessel Tunics 684 23.1b Arteries 685 23.1c Capillaries 688 23 23.1d Veins 689 23.2 Blood Pressure 691 23.3 Systemic Circulation 692 Vessels and 23.3a General Arterial Flow Out of the Heart 693 23.3b General Venous Return to the Heart 693 23.3c Blood Flow Through the Head and Neck 693 23.3d Blood Flow Through the Thoracic and Abdominal Walls 697 23.3e Blood Flow Through the Thoracic Organs 700 Circulation 23.3f Blood Flow Through the Gastrointestinal Tract 701 23.3g Blood Flow Through the Posterior Abdominal Organs, Pelvis, and Perineum 705 23.3h Blood Flow Through the Upper Limb 705 23.3i Blood Flow Through the Lower Limb 709 23.4 Pulmonary Circulation 712 23.5 Review of Heart, Systemic, and Pulmonary Circulation 714 23.6 Aging and the Cardiovascular System 715 23.7 Blood Vessel Development 716 23.7a Artery Development 716 23.7b Vein Development 717 23.7c Comparison of Fetal and Postnatal Circulation 718 MODULE 9: CARDIOVASCULAR SYSTEM mck78097_ch23_683-723.indd 683 2/14/11 4:31 PM 684 Chapter Twenty-Three Vessels and Circulation lood vessels are analogous to highways—they are an efficient larger as they merge and come closer to the heart. The site where B mode of transport for oxygen, carbon dioxide, nutrients, hor- two or more arteries (or two or more veins) converge to supply the mones, and waste products to and from body tissues. The heart is same body region is called an anastomosis (ă-nas ′tō -mō′ sis; pl., the mechanical pump that propels the blood through the vessels. -
Human Anatomy As Related to Tumor Formation Book Four
SEER Program Self Instructional Manual for Cancer Registrars Human Anatomy as Related to Tumor Formation Book Four Second Edition U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutesof Health SEER PROGRAM SELF-INSTRUCTIONAL MANUAL FOR CANCER REGISTRARS Book 4 - Human Anatomy as Related to Tumor Formation Second Edition Prepared by: SEER Program Cancer Statistics Branch National Cancer Institute Editor in Chief: Evelyn M. Shambaugh, M.A., CTR Cancer Statistics Branch National Cancer Institute Assisted by Self-Instructional Manual Committee: Dr. Robert F. Ryan, Emeritus Professor of Surgery Tulane University School of Medicine New Orleans, Louisiana Mildred A. Weiss Los Angeles, California Mary A. Kruse Bethesda, Maryland Jean Cicero, ART, CTR Health Data Systems Professional Services Riverdale, Maryland Pat Kenny Medical Illustrator for Division of Research Services National Institutes of Health CONTENTS BOOK 4: HUMAN ANATOMY AS RELATED TO TUMOR FORMATION Page Section A--Objectives and Content of Book 4 ............................... 1 Section B--Terms Used to Indicate Body Location and Position .................. 5 Section C--The Integumentary System ..................................... 19 Section D--The Lymphatic System ....................................... 51 Section E--The Cardiovascular System ..................................... 97 Section F--The Respiratory System ....................................... 129 Section G--The Digestive System ......................................... 163 Section -
Lymphatic Drainage of the Breast: from Theory to Surgical Practice
Int. J. Morphol., 27(3):873-878, 2009. Lymphatic Drainage of the Breast: from Theory to Surgical Practice Drenaje Linfático de la Mama: desde la Teoría a la Práctica Quirúrgica *José Humberto Tavares Guerreiro Fregnani & **José Rafael Macéa FREGNANI, J. H. T. G. & MACÉA, J. R. Lymphatic drainage of the breast: from theory to surgical practice. Int. J. Morphol., 27(3):873-878, 2009. SUMMARY: Until recently, complete removal of axillary lymph nodes was performed as part of the treatment of breast cancer. Sentinel lymph node biopsy (SLNB) in selected cases has reduced the number of cases of wide axillary dissection and the related morbidity. Knowledge of breast lymphatic drainage is essential for understanding the principles behind SLNB and also for performing safe and correct axillary lymphonodectomy. This paper describes in detail the anatomical issues relating to breast lymphatic drainage and the correlated axillary and extra-axillary lymph nodes. In addition, it shows the application of this theoretical knowledge to surgical practice, especially with regard to SLNB and lymphonodectomy. The surgical nomenclature is compared with the current International Anatomical Terminology. KEY WORDS: Lymphatic drainage, Sentinel lymph node biopsy, Breast cancer. INTRODUCTION Breast cancer is the most frequent type of tumor changes to the sensitivity of the upper limb, posterior scapular among women, accounting for approximately one quarter dislocation (winged scapula syndrome), brachial plexus of all tumors in women. It has been estimated that more than lesions, axillary vessel thrombosis and lesions, skin necrosis one million new cases occur worldwide annually. Breast and pectoral muscle atrophy, among others (Torresan et al., cancer is responsible for significant morbidity and mortality 2002; Kim et al., 2006). -
The Lymphoid System
LYMPHATIC SYSTEM MUDr. Hisham El Falougy, PhD. [email protected] Lymphoid cells Lymphoid organs: primary and secondary Lymphoid vessels lymph The lymphoid cells B lymphocytes Plasma cells Humeral immunity (IgG, IgA, IgM, IgD, IgE) B memory cells The lymphoid cells T lymphocytes Cellular imunity Cytotoxic cells Helper cells Supressor cells T memory cells The lymphoid cells Antigen-presenting cells Macrophages Epidermal Langerhans cells Dendritic cells of lymphoid organs M cells The primary lymphoid organs Bone marrow Red bone marrow Yellow bone marrow Thymus The secondary lymphoid organs Spleen Lymph nodes Unencapsulated lymphoid tissue Tonsils LYMPHATIC SYSTEM FUNCTIONS: TRANSPORTS EXCESS INTERSTITIAL FLUID ABSORBS AND TRANSPORTS FAT FROM INTESTINE IMMUNOLOGICAL FUNCTION LYMPH AND LYMPH CAPILLARIES LYMPH CAPILLARIES SMALLEST LYMPHATIC VESSELS CLOSED-ENDED TUBES FORM NETWORK IN THE INTERCELLULAR SPACES LACTEALS (SMALL INTESTINE) LYMPH AND LYMPH CAPILLARIES LYMPH CAPILLARIES ENDOTHELIUM LACK A BASAL LAMINA PERMAEABLE TO LARGER MOLECULES LYMPH AND LYMPH CAPILLARIES LYMPH CAPILLARIES ABSENT FROM: AVASCULAR STRUCTURES CNS BONE MARROW VERY FEW IN ENDOMYSIUM OF SKELETAL MUSCLES LYMPH AND LYMPH CAPILLARIES LYMPH FILTRATE OF PLASMA CLEAR AND COLOURLESS DENSE AND MILKY CHYLE LYMPHATIC VESSELS LYMPH CAPILLARIES JOIN INTO LARGER LYMPHATIC VESSELS PASS TO LOCAL OR REMOTE LYMPH NODES REPAIR EASILY Lymphatic vessels and lymph Vasa lymphocapillaria Rete lymphocapillare Collectores lymphatici -
A Study of Evaluation and Management of Rare Congenital Breast Diseases Surgery Section
Original Article DOI: 10.7860/JCDR/2016/21077.8648 A Study of Evaluation and Management of Rare Congenital Breast Diseases Surgery Section RIKKI SINGAL1, SUDHIR KUMAR MEHTA2, JYOTI BALA3, MUZZAFAR ZAMAN4, AMIT MITTAL5, GUARAV GUPTA6, SAMER RUDRA7, SAMITA SINGAL8 ABSTRACT Results: Out of 32 cases: 1(3.125%) male patient had Introduction: Polymastia and polythelia may be asymptomatic unilateral and 1(3.125%) male had bilateral accessory nipple, or cause pain, restriction of arm movement, milk discharge, 7 (21.87%) females had unilateral and 1(3.125%) had bilateral cosmetic problems or anxiety. Cosmesis is the main indication accessory nipple, 1 (3.125%) diagnosed as accessory axillary for surgical excision of accessory breasts in axilla. In addition fibroadenoma in female, 16(50%) presented as unilateral and 5 it also confirms the diagnosis and allays the patient’s fear of (15.62%) had bilateral swelling in the axilla as accessory breast. harbouring a malignancy. Patients underwent surgical excision and in 8(25%) cases z- shaped incision was made in view of better cosmesis. Patients Aim: To evaluate the presentation of symptoms, investigations were followed up upto 6 months postoperatively. There were no required for diagnosis and the management to improve the residual swelling and movements of the arm over the shoulder treatment protocols in patients with breast diseases. joint were normal. In 3(9.37%) cases, wound dehiscence Materials and Methods: This retrospective study on breast occurred; in 2 (6.25%) cases lymphoedema formation was diseases presenting as supernumerary breasts and nipples seen. These were successfully managed conservatively. was conducted in the Department of Surgery between January Conclusion: As breast swellings either fibroadenoma or 2013 and January 2016 at MMIMS Research and hospital, carcinoma are common entities to come across everywhere Mullana, Ambala. -
Inverted Nipple Repair Revisited: a 7-Year Experience
Breast Surgery Aesthetic Surgery Journal 2015, Vol 35(2) 156–164 Inverted Nipple Repair Revisited: A 7-Year © 2015 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: Experience [email protected] DOI: 10.1093/asj/sju113 www.aestheticsurgeryjournal.com Daniel J. Gould, MD, PhD; Meghan H. Nadeau, MD; Luis H. Macias, MD; and W. Grant Stevens, MD Abstract Background: Nipple inversion in females can be congenital or acquired. Women who desire treatment for this condition often report difficulty with breastfeeding and interference with their sexuality. However, data are limited on the demographics of patients who undergo surgery to repair inverted nipples and the associated recurrence rates and complications. Objectives: The authors assessed outcomes of a 7-year experience with an integrated approach to the correction of nipple inversion that minimizes ductal disruption. Methods: A retrospective chart review was performed for 103 consecutive patients who underwent correction of nipple inversion. (The correction tech- nique was initially reported in 2004 and entailed an integrated approach.) Complication rates, breastfeeding status, and patient demographics were docu- mented. Results: Among the 103 patients, 191 nipple corrections were performed. Nine patients had undergone previous nipple-correction surgery. Recurrence was experienced by 12.6% of patients, 3 of whom had bilateral recurrence. Other complications were partial nipple necrosis (1.05%), breast cellulitis (1.57%), and delayed healing (0.5%). The overall complication rate was 15.74%. Fifty-seven percent of the patients had a B-cup breast size, and 59% were 21 to 30 years of age. Conclusions: Results of the authors’ 7-year experience demonstrate the safety and effectiveness of their technique to correct inverted nipples. -
Anatomy and Physiology in Relation to Compression of the Upper Limb and Thorax
Clinical REVIEW anatomy and physiology in relation to compression of the upper limb and thorax Colin Carati, Bren Gannon, Neil Piller An understanding of arterial, venous and lymphatic flow in the upper body in normal limbs and those at risk of, or with lymphoedema will greatly improve patient outcomes. However, there is much we do not know in this area, including the effects of compression upon lymphatic flow and drainage. Imaging and measuring capabilities are improving in this respect, but are often expensive and time-consuming. This, coupled with the unknown effects of individual, diurnal and seasonal variances on compression efficacy, means that future research should focus upon ways to monitor the pressure delivered by a garment, and its effects upon the fluids we are trying to control. More is known about the possible This paper will describe the vascular Key words effects of compression on the anatomy of the upper limb and axilla, pathophysiology of lymphoedema when and will outline current understanding of Anatomy used on the lower limbs (Partsch and normal and abnormal lymph drainage. It Physiology Junger, 2006). While some of these will also explain the mechanism of action Lymphatics principles can be applied to guide the use of compression garments and will detail Compression of compression on the upper body, it is the effects of compression on fluid important that the practitioner is movement. knowledgeable about the anatomy and physiology of the upper limb, axilla and Vascular drainage of the upper limb thorax, and of the anatomical and vascular It is helpful to have an understanding of Little evidence exists to support the differences that exist between the upper the vascular drainage of the upper limb, use of compression garments in the and lower limb, so that the effects of these since the lymphatic drainage follows a treatment of lymphoedema, particularly differences can be considered when using similar course (Figure 1). -
GROSS ANATOMY Lecture Syllabus 2008
GROSS ANATOMY Lecture Syllabus 2008 ANAT 6010 - Gross Anatomy Department of Neurobiology and Anatomy University of Utah School of Medicine David A. Morton K. Bo Foreman Kurt H. Albertine Andrew S. Weyrich Kimberly Moyle 1 GROSS ANATOMY (ANAT 6010) ORIENTATION, FALL 2008 Welcome to Human Gross Anatomy! Course Director David A. Morton, Ph.D. Offi ce: 223 Health Professions Education Building; Phone: 581-3385; Email: [email protected] Faculty • Kurt H. Albertine, Ph.D., (Assistant Dean for Faculty Administration) ([email protected]) • K. Bo Foreman, PT, Ph.D, (Gross and Neuro Anatomy Course Director in Dept. of Physical Therapy) (bo. [email protected]) • David A. Morton, Ph.D. (Gross Anatomy Course Director, School of Medicine) ([email protected]. edu) • Andrew S. Weyrich, Ph.D. (Professor of Human Molecular Biology and Genetics) (andrew.weyrich@hmbg. utah.edu) • Kerry D. Peterson, L.F.P. (Body Donor Program Director) Cadaver Laboratory staff Jordan Barker, Blake Dowdle, Christine Eckel, MS (Ph.D.), Nick Gibbons, Richard Homer, Heather Homer, Nick Livdahl, Kim Moyle, Neal Tolley, MS, Rick Webster Course Objectives The study of anatomy is akin to the study of language. Literally thousands of new words will be taught through- out the course. Success in anatomy comes from knowing the terminology, the three-dimensional visualization of the structure(s) and using that knowledge in solving problems. The discipline of anatomy is usually studied in a dual approach: • Regional approach - description of structures regionally -
Diagnosis and Treatment of Accessory Breast Cancer in 11 Patients
ONCOLOGY LETTERS 10: 1783-1788, 2015 Diagnosis and treatment of accessory breast cancer in 11 patients SHUO ZHANG1,2*, YONG-HUA YU2, WEI QU2, YONG ZHANG2* and JIA LI2 1School of Medical and Life Sciences, Shandong Academy of Medical Sciences, Jinan University, Jinan, Shandong 250200; 2Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, P.R. China Received August 21, 2014; Accepted May 8, 2015 DOI: 10.3892/ol.2015.3388 Abstract. The present study aimed to investigate the clinical from the ectodermal ridges, also known as the milk lines, on characteristics, diagnosis and treatment of accessory breast the ventral surface of the body, which extend from the axillae cancer, and contribute valuable information regarding this to the inguinal regions and end on the medial aspect of the rare tumour to the current literature, ultimately facilitating thighs on each side of the body (4). Embryologically, ectopic the development of improved treatment strategies. The present breast tissue develops as a result of failed resolution of the study reported the cases of 11 patients with accessory breast mammary ridge, an ectodermal thickening that extends from cancer. The patients with accessory breast cancer were the axilla to the groin (5). Ectopic breast tissue may appear at admitted between January 2002 and June 2014, and the patient any site along the milk line, but it occurs most commonly in records were retrospectively analysed. All patients presented the axill; less commonly, it may appear in locations outside with a tumour that was localised in the axilla. Out of these of the mammary ridge, including the face, middle back, patients, there were 8 patients with invasive ductal carcinoma buttock, posterior neck, chest, vulva, hip, posterior, flank and 3 patients with invasive lobular carcinoma. -
Agenesis of Lactiferous Duct of Breast – a Case Presentation
Agenesis of Lactiferous Duct of Breast – A Case Presentation Daniel Burchette*, Robert Mcgovern*, K Hemalatha**, M Paul Korath***, K Mohandass****, K Jagadeesan+ Introduction the presence of numerous macrophages and neutrophils on a thick eosinophilic background, galactocoele is a benign breast lesion consistent with the an infected cystic lesion. The Aconsisting of a cyst containing thick, patient had no past medical history of mastitis. On milky fluid with a high fat content, most closer examination of the nipples, duct openings were commonly seen in a young lactating women.1 absent from the 9 o’clock to 11 o’clock positions on A blocked lactiferous duct, generally as a the right side, consistent with the positioning of the galactocoele. Pits in this region were explored using a result of fibrosis from previous infection, is 3-0 lacrimal duct probe (Fig. 1), but all were blind normally the cause. Patients usually present ending. Cranio caudal and medio lateral oblique views with a painless palpable lump in the breast on mammography demonstrated lactating breast with which is freely mobile. Treatment is complete galactocoele in right breast and significant right aspiration, which is generally successful. axillary lymphadenopathy – BI-RADS category II and Recurrence is common following successive agenesis of ducts in the right upper outer quadrant (Fig. 2A,2B). Imaging of the lactiferous ductal systems pregnancies. We present a young primiparous of both breasts using high resolution ultrasound woman with a galactocoele caused by an identified an absence of lactiferous ducts in the upper agenesis or atresia of lactiferous ducts. segment of the right breast (Fig.