CHEM 360 - Cambridge Scientists
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
The Creation of Neuroscience
The Creation of Neuroscience The Society for Neuroscience and the Quest for Disciplinary Unity 1969-1995 Introduction rom the molecular biology of a single neuron to the breathtakingly complex circuitry of the entire human nervous system, our understanding of the brain and how it works has undergone radical F changes over the past century. These advances have brought us tantalizingly closer to genu- inely mechanistic and scientifically rigorous explanations of how the brain’s roughly 100 billion neurons, interacting through trillions of synaptic connections, function both as single units and as larger ensem- bles. The professional field of neuroscience, in keeping pace with these important scientific develop- ments, has dramatically reshaped the organization of biological sciences across the globe over the last 50 years. Much like physics during its dominant era in the 1950s and 1960s, neuroscience has become the leading scientific discipline with regard to funding, numbers of scientists, and numbers of trainees. Furthermore, neuroscience as fact, explanation, and myth has just as dramatically redrawn our cultural landscape and redefined how Western popular culture understands who we are as individuals. In the 1950s, especially in the United States, Freud and his successors stood at the center of all cultural expla- nations for psychological suffering. In the new millennium, we perceive such suffering as erupting no longer from a repressed unconscious but, instead, from a pathophysiology rooted in and caused by brain abnormalities and dysfunctions. Indeed, the normal as well as the pathological have become thoroughly neurobiological in the last several decades. In the process, entirely new vistas have opened up in fields ranging from neuroeconomics and neurophilosophy to consumer products, as exemplified by an entire line of soft drinks advertised as offering “neuro” benefits. -
The Birth of Information in the Brain: Edgar Adrian and the Vacuum Tube,” Science in Context 28: 31-52
Garson, J. (2015) “The Birth of Information in the Brain: Edgar Adrian and the Vacuum Tube,” Science in Context 28: 31-52. Preprint (not copyedited or formatted) Please use DOI when citing or quoting: https://doi- org.proxy.wexler.hunter.cuny.edu/10.1017/S0269889714000313 The Birth of Information in the Brain: Edgar Adrian and the Vacuum Tube Word Count: 10, 418 Abstract: As historian Henning Schmidgen notes, the scientific study of the nervous system would have been ‘unthinkable’ without the industrialization of communication in the 1830s. Historians have investigated extensively the way nerve physiologists have borrowed concepts and tools from the field of communications, particularly regarding the nineteenth-century work of figures like Helmholtz and in the American Cold War Era. The following focuses specifically on the interwar research of the Cambridge physiologist Edgar Douglas Adrian, and on the technology that led to his Nobel-Prize- winning research, the thermionic vacuum tube. Many countries used the vacuum tube during the war for the purpose of amplifying and intercepting coded messages. These events provided a context for Adrian’s evolving understanding of the nerve fiber in the 1920s. In particular, they provide the background for Adrian’s transition around 1926 to describing the nerve impulse in terms of “information,” “messages,” “signals,” or even “codes,” and for translating the basic principles of the nerve, such as the all-or-none principle and adaptation, into such an “informational” context. The following also places Adrian’s research in the broader context of the changing relationship between science and technology, and between physics and physiology, in the first few decades of the twentieth century. -
The Fessard's School of Neurophysiology After
The fessard’s School of neurophysiology after the Second World War in france: globalisation and diversity in neurophysiological research (1938-1955) Jean-Gaël Barbara To cite this version: Jean-Gaël Barbara. The fessard’s School of neurophysiology after the Second World War in france: globalisation and diversity in neurophysiological research (1938-1955). Archives Italiennes de Biologie, Universita degli Studi di Pisa, 2011. halshs-03090650 HAL Id: halshs-03090650 https://halshs.archives-ouvertes.fr/halshs-03090650 Submitted on 11 Jan 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. The Fessard’s School of neurophysiology after the Second World War in France: globalization and diversity in neurophysiological research (1938-1955) Jean- Gaël Barbara Université Pierre et Marie Curie, Paris, Centre National de la Recherche Scientifique, CNRS UMR 7102 Université Denis Diderot, Paris, Centre National de la Recherche Scientifique, CNRS UMR 7219 [email protected] Postal Address : JG Barbara, UPMC, case 14, 7 quai Saint Bernard, 75005, -
1. Overview 2. Database Architecture 3. Example Tree 6. Mentorship Network Influences?
Neurotree: Graphing the academic genealogy of neuroscience Stephen V. David1, Will Chertoff1, Titipat Achakulvisut2, Daniel Acuna2 1Oregon Health & Science University, 2Northwestern University 1. Overview 3. Example tree 4. Founding ancestors Neurotree (http://neurotree.org, [1]) is a collaborative, open-access Name N Resarch area Family tree The distance between two nodes can be Johannes Müller 7715 Physiology website that tracks and visualizes the academic genealogy and history P+ William Fitch measured by the number of mentorship Sir Charles Sherrington 4758 Neurophysiology of neuroscience. After 10 years of growth driven by user-generated Allen Hermann von Helmholtz 3048 Psychophysics University of P- steps connecting them through a Sir John Eccles 2998 Synapses content, the site has captured information about the mentorship of over Rudolf Oregon Ludwig Robert Samuel Alexander Sir Charles Medical common ancestor i(below). The list at Karl Lashley 2558 Learning and memory 80,000 neuroscientists. It has become a unique tool for a community of John Friedrich Karl Koch Sir Charles Kinnier Charles Gordon John Scott Sir Charles Harvey Sir Charles Karl Edgar School C+ Louis Agassiz 2241 Anatomy Sir Michael Newport Goltz Virchow Universität Scott Wilson Symonds Holmes Farquhar Sherrington Scott Williams Scott Spencer Wilder Douglas Frederic right shows the 30 most frequent primary researchers, students, journal editors, and the press. Once Foster Langley Kaiser-Wilhelms- Universität Berlin (ID Sherrington National Hospital, Queen National -
Research Organizations and Major Discoveries in Twentieth-Century Science: a Case Study of Excellence in Biomedical Research
A Service of Leibniz-Informationszentrum econstor Wirtschaft Leibniz Information Centre Make Your Publications Visible. zbw for Economics Hollingsworth, Joseph Rogers Working Paper Research organizations and major discoveries in twentieth-century science: A case study of excellence in biomedical research WZB Discussion Paper, No. P 02-003 Provided in Cooperation with: WZB Berlin Social Science Center Suggested Citation: Hollingsworth, Joseph Rogers (2002) : Research organizations and major discoveries in twentieth-century science: A case study of excellence in biomedical research, WZB Discussion Paper, No. P 02-003, Wissenschaftszentrum Berlin für Sozialforschung (WZB), Berlin This Version is available at: http://hdl.handle.net/10419/50229 Standard-Nutzungsbedingungen: Terms of use: Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Documents in EconStor may be saved and copied for your Zwecken und zum Privatgebrauch gespeichert und kopiert werden. personal and scholarly purposes. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle You are not to copy documents for public or commercial Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich purposes, to exhibit the documents publicly, to make them machen, vertreiben oder anderweitig nutzen. publicly available on the internet, or to distribute or otherwise use the documents in public. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, If the documents have been made available under an Open gelten abweichend von diesen Nutzungsbedingungen die in der dort Content Licence (especially Creative Commons Licences), you genannten Lizenz gewährten Nutzungsrechte. may exercise further usage rights as specified in the indicated licence. www.econstor.eu P 02 – 003 RESEARCH ORGANIZATIONS AND MAJOR DISCOVERIES IN TWENTIETH-CENTURY SCIENCE: A CASE STUDY OF EXCELLENCE IN BIOMEDICAL RESEARCH J. -
The Fessard's School of Neurophysiology After the Second
Archives Italiennes de Biologie, 149 (Suppl.): 187-195, 2011. The fessard’s School of neurophysiology after the Second World War in france: globalisation and diversity in neurophysiological research (1938-1955) J.-G. BARBARA Université Pierre et Marie Curie, Paris, Centre National de la Recherche Scientifique, CNRS UMR 7102; Université Denis Diderot, Paris, Centre National de la Recherche Scientifique, CNRS UMR 7219 ABSTRACT In France, neurophysiology emerged after the Second World War as a dynamic discipline in different schools, Toulouse, Lyons, Montpellier, Marseilles, and Paris, where Lapicque was losing credit with his studies on the excitability of nerves. Parisian neurophysiologist, Alfred Fessard (1900-1982) was a key figure in establishing a new school of neurophysiology on the model of Edgar Adrian’s department in Cambridge, where he worked for a few months in the late thirties. Fessard was initially a student of Henri Piéron involved in experimental psychology. He also made parallel oscillographic studies on elementary activities in various animal and plant preparations. His school trained leading French neurophysiologists in Paris until recently and Fessard was instrumental in the creation of IBRO in 1961. Key words Neurophysiology • France • Fessard • IBRO • Torpedo fish • Chemical neurotransmission After the Second World War, major French figures Marey suggested the creation of an International in neurophysiology emerged from different tradi- Commission for the control of graphical instruments tions in Toulouse, Lyons Montpellier, Strasburg, devoted to physiology. A new cottage named Institut Marseilles, and Paris. Alfred Fessard (1900-1982) is Marey was built near the Physiological Station recognized today as a most talented neurophysiolo- Marey had planned for his studies on movement in gist in the 1940s and 1950s who was able to create Boulogne-Billancourt, Le Parc des Princes, near his own school near Paris, in the former Institut Paris. -
Williams Dissertation 4.17.12
ACTIVATION, DESENSITIZATION AND POTENTIATION OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS: RELEVANCE TO ALPHA7-TARGETED THERAPEUTICS By DUSTIN KYLE WILLIAMS A DISSERTATION PRESENTED TO THE GRADUATE SCHOOL OF THE UNIVERSITY OF FLORIDA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY UNIVERSITY OF FLORIDA 2012 1 © 2012 Dustin Kyle Williams 2 To the most important people in my life: my family 3 ACKNOWLEDGMENTS I would like to thank my wife, Julie Williams, and my parents, Kevin and Kathy Williams for their unconditional love and flawless support through the graduate school experience, even when I have had to place work before them. I would like to thank Dr. Roger Papke for his mentorship over the last five years. I have had more success under his arm than I ever could have expected when I started graduate school. In addition, I am thankful for the many collaborative meetings I participated in with Dr. Nicole Horenstein and Dr. Jingyi Wang. I would like to thank Mathew Kimbrell for his fine work in helping to create the stably transfected cell lines, and for the interactions I have had with all members of the Papke laboratory. I wish to express gratitude to the members of my advisory committee, Dr. Nicole Horenstein, Dr. Brian Cooper, Dr. Michael King, and Dr. Brian Law, for their counsel and guidance. I am thankful for the financial support I have received from the National Institute on Aging Training Grant T32-AG000196. 4 TABLE OF CONTENTS Page ACKNOWLEDGMENTS ................................................................................................... 4 LIST OF TABLES ............................................................................................................. 8 LIST OF FIGURES ........................................................................................................... 9 LIST OF ABBREVIATIONS ........................................................................................... -
Sir Charles Scott Sherrington (1857–1952)
GENERAL ARTICLE Sir Charles Scott Sherrington (1857–1952) Prasanna Venkhatesh V Twentieth century bore witness to remarkable scientists who have advanced our understanding of the brain. Among them, Sir Charles Scott Sherrington’s ideas about the way in which the central nervous system operates has continuing relevance even today. He received honorary doctorates from twenty- two universities and was honoured with the Nobel Prize in Physiology or Medicine in the year 1932 along with Lord Prasanna Venkhatesh V is Edgar Adrian for their work on the functions of neurons. He currently a graduate developed our modern notion of the reflex as a model for how student at the Center for the periphery and spinal cord connect sensation and action. Neuroscience working with Prof. Aditya Murthy. He is “...To move things is all that mankind can do, for such the sole working on voluntary control of reaching and executant is muscle, whether in whispering a syllable or in felling pointing movements. His aforest.” research interests are –Sherrington neural basis of motor control and animal Sherrington had the genius to see the real need to amalgamate the behavior. scattered ideas in neurophysiology at that time, to give a compre- hensive overview that changed our perception of brain functions. In a career spanning almost sixty-five years, he published more than three hundred and twenty articles and a couple of noteworthy books. He was a man of admirable qualities and greatness, which is evident from the enviable number of articles, commentaries and books that have been written about his life, his approach to science and the world in general. -
The Neuro Nobels
NEURO NOBELS Richard J. Barohn, MD Gertrude and Dewey Ziegler Professor of Neurology University Distinguished Professor Vice Chancellor for Research President Research Institute Research & Discovery Director, Frontiers: The University of Kansas Clinical and Translational Science Grand Rounds Institute February 14, 2018 1 Alfred Nobel 1833-1896 • Born Stockholm, Sweden • Father involved in machine tools and explosives • Family moved to St. Petersburg when Alfred was young • Father worked on armaments for Russians in the Crimean War… successful business/ naval mines (Also steam engines and eventually oil).. made and lost fortunes • Alfred and brothers educated by private teachers; never attended university or got a degree • Sent to Sweden, Germany, France and USA to study chemical engineering • In Paris met the inventor of nitroglycerin Ascanio Sobrero • 1863- Moved back to Stockholm and worked on nitro but too dangerous.. brother killed in an explosion • To make it safer to use he experimented with different additives and mixed nitro with kieselguhr, turning liquid into paste which could be shaped into rods that could be inserted into drilling holes • 1867- Patented this under name of DYNAMITE • Also invented the blasting cap detonator • These inventions and advances in drilling changed construction • 1875-Invented gelignite, more stable than dynamite and in 1887, ballistics, predecessor of cordite • Overall had over 350 patents 2 Alfred Nobel 1833-1896 The Merchant of Death • Traveled much of his business life, companies throughout Europe and America • Called " Europe's Richest Vagabond" • Solitary man / depressive / never married but had several love relationships • No children • This prompted him to rethink how he would be • Wrote poetry in English, was considered remembered scandalous/blasphemous. -
Research Organizations and Major Discoveries in Twentieth-Century Science: a Case Study of Excellence in Biomedical Research Hollingsworth, J
www.ssoar.info Research organizations and major discoveries in twentieth-century science: a case study of excellence in biomedical research Hollingsworth, J. Rogers Veröffentlichungsversion / Published Version Arbeitspapier / working paper Zur Verfügung gestellt in Kooperation mit / provided in cooperation with: SSG Sozialwissenschaften, USB Köln Empfohlene Zitierung / Suggested Citation: Hollingsworth, J. R. (2002). Research organizations and major discoveries in twentieth-century science: a case study of excellence in biomedical research. (Papers / Wissenschaftszentrum Berlin für Sozialforschung, 02-003). Berlin: Wissenschaftszentrum Berlin für Sozialforschung gGmbH. https://nbn-resolving.org/urn:nbn:de:0168-ssoar-112976 Nutzungsbedingungen: Terms of use: Dieser Text wird unter einer Deposit-Lizenz (Keine This document is made available under Deposit Licence (No Weiterverbreitung - keine Bearbeitung) zur Verfügung gestellt. Redistribution - no modifications). We grant a non-exclusive, non- Gewährt wird ein nicht exklusives, nicht übertragbares, transferable, individual and limited right to using this document. persönliches und beschränktes Recht auf Nutzung dieses This document is solely intended for your personal, non- Dokuments. Dieses Dokument ist ausschließlich für commercial use. All of the copies of this documents must retain den persönlichen, nicht-kommerziellen Gebrauch bestimmt. all copyright information and other information regarding legal Auf sämtlichen Kopien dieses Dokuments müssen alle protection. You are not allowed -
Hodgkin and Huxley Model
Chapter 5 Hodgkin and Huxley Model 5.1 Vocabulary • Depolarization • Positive Feedback • Hyperpolarization • Negative Feedback • Membrane Potential • Sodium-Potassium Pump • Nernst Potential • Reversal Potential • Equilibrium Potential • Driving Force • Conductance • Leak Current • Leaky Integrate and Fire Model • Absolute Refractory Period • Gating variable 5.2 Introduction Before you read this chapter, we would like to draw your attention to this video. We call this a Zombie Squid because the squid is in fact dead; however, it is recently deceased. Since the squid passed shortly before, Adenosine triphosphate (ATP) energy stores are still available to the squid’s muscles. When the soy sauce, which has a lot of sodium chloride (salt) in it, is poured onto the squid, the salt in the soy sauce causes a voltage change which causes the squid’s muscles to contract. Thus, we have a Zombie Squid. So why is the Zombie Squid important? The Hodgkin-Huxley Model, said to 47 48 CHAPTER 5. HODGKIN AND HUXLEY MODEL have started the field of computational neuroscience, all hinges on the giant axons of squid. In the 1950s Alan Hodgkin and Andrew Huxley built a model that shows us how computers can successfully predict certain aspects of the brain that cannot be directly studied. The two even won a Nobel Prize in Physiology or Medicine in 1963 with Sir John Carew Eccles for their model. The Hodgkin-Huxley Model is now the basis of all conductance-based models. As a result, we can now understand how an action potential works, and why it is an all-or-none event. While Hodgkin and Huxley created their model in the 1950s, the first recording of an action potential was done by Edgar Adrian in the 1920s. -
Friday, May 15, 2020 the University of Arizona
FRIDAY, MAY 15, 2020 THE UNIVERSITY OF ARIZONA It was in 1885 that the Thirteenth Territorial Legislature founded the University of Arizona with an appropriation of $25,000 — but no land. This appropriation was not welcomed by many residents of Tucson and Pima County, as they were looking for either the state Capitol building, a prison, or even an asylum for the insane — but definitely not a university. The money would be available on the condition that the community provided a suitable site. Just before the $25,000 was to be returned to the Legislature, two gamblers and a saloon-keeper donated 40 acres of land “way out east of town,” and thus the University could become a reality. Classes began in 1891 with 32 students and six teachers, all accommodated in one building. The first class graduated in 1895, when three students received their degrees. Today, the University of Arizona is one of the nation's top public universities, according to U.S. News & World Report. It has grown to more than 45,000 students and 15,000 faculty and staff members across the University, which includes the main campus, the College of Applied Science & Technology in Sierra Vista, the College of Medicine – Phoenix and Arizona Online. The University is organized into 21 colleges and 23 schools. It is one of the top 10 employers in Arizona, with an economic impact of more than $1 billion in fiscal year 2017 as a result of the University’s research expenditures. 156th Annual Arizona COMMENCEMENT Table of Contents STREAMED PROGRAM · · · · · · · · · · · · · · · ·