CURRICULUM VITAE

Name: John E. Koundourellis Address: School of Pharmacy, Department of Pharmaceutical Technology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. Tel: +302310997643, Fax: +302310997652 e-mail: [email protected] Job Title: Associate Professor Marital status: Married / two children

Education 1973 Pharmacy degree (School of Pharmacy, Aristotelian University of Thessaloniki, Greece) 1978 M. Phil. Degree (School of Pharmacy, University of Bath, Avon, England) 1981 Ph.D (School of Pharmacy, University of Bath, Avon, England)

Research Interests: · Development various chromatographic systems for the quantification of drugs and their metabolites in pharmaceutical preparations and in biological fluids · Quantification of drugs by employing zero order and derivative spectra · Characterization of drugs and their polymorphic forms using X-ray diffraction data Infrared and Raman Spectrophotometry

Publications:

Theses 1. J. E. Kountourellis, Spectrometric and Spectrophotometric Analysis of 2- lmidazolines, M. Phil Thesis, Bath University, September 1978

2. J. E. Kountourellis, Carbon -13 NMR Quantitative and Qualitative Analysis. Ph. D. Thesis, Bath University, September 1981

Papers in Scientific Journals 1. × - Ray Powder Diffraction Data for Nine Medicinal 2 - Imidazolines J.T.R. Owen, J.E. Kountourellis, F.A. Underwood, Journal of the Association of Official Analytical Chemists 64, No 5,1164 - 1173(1981).

2. Studies of carbon -13 n.m.r. spectroscopy in pharmaceutical analysis: the composition of commercial samples of gentamicin sulphate. J.E. Kountourellis, R.T. Parfitt, A.F. Casy Journal of Pharmacy and Pharmacology 35: 279-283 (1983).

3. Mass Spectra and Fragmentation Pathways of two Medicinal Aryl -I midazo-lines under Electron Impact. J.E. Kountourellis, Pharmakeftiko Deltio, Vol X, 47- 54, (1984)

4. Ultraviolet Spectral Structure Studies of Five Amidines of Pharmaceutica Énterest, I.E. Kountourellis, Pharmakeftiko Deltio, Scientific Edition, XI, 43-53 (1985).

5. X-ray powder diffraction data for propantheline bromide J.E. Kountourellis and A. Raptouli. Acta Pharmaceutica Suecica, Vol.22,1,59-61 (1985)

6. Determination of Thermodynamic lonization Constants for Eight Medici- nal Benzylimidazolines. J.E. Kountourellis, N. Papadopoulos and A. Raptouli. Talanta,Vol.31,9,730 (1984).

7. Determination of Vitamin A and Å in Pharmaceutical Preparations by HPLC Method. J.E. Kountourellis, A. Raptouli, N.A. Botsoglou and M. Georgarakis. Die Pharmazie 40,H.3, 193-194 (1985).

8. Quantitative applications of 13C NMR Spectroscopy to pharmaceutical analysis J.E. Kountourellis Pharmacy International Vol. 7, 2, 4145 (1986) 9. Simultaneous determination of bromochlorosalicylanillideand bamipine in pharmaceutical formulations by High Performance Liquid Chromatography. J.E. Kountourellis, A. Raptouli and P.P. Georgakopoulos Journal of Chromatography,362,3439-42(1986)

10. Simultaneous Determination of Aminophylline and Promethazine in Suppositories by High-Performance Liquid Chromatography. John E. Kountourellis, Antonia Raptouli and Manoiis Georgarakis, Die Pharmazie, Vol. 41, 4-8 (1986)

11. × – Ray Diffraction data for six analgesics. J.E. Kountourellis, F.A. Underwood, and P.P. Georgakopoulos and A. Raptouli Talanta, Vol. 33 No 7 631-632 (1986)

12. Simultaneous Determination of 2-imidazolines and Other Pharmaceutical Substances in Commercial Preparations by High- Per-formance Liquid-Chromatography. J.E. Kountourellis and A. Raptouli Analytical Letters, 21 (8), 1361-1370 (1988)

13. An Analytical Study of Eight Medicinal 2-lmidazolines by Ç and 13C Nuclear Magnetic Resonance Spectroscopy. J.E. Kountourellis Pharmazie 43, Ç 1, 26-29 (1988)

14. Effect of Particle Size, Content in Lubricant, Mixing Time and Storage Relative Humidity on Drug Release from Hard Gelatin Capsules. M. Georgarakis, P. Hatzipantou and J.E. Kountourellis. Drug Development and Industrial Pharmacy 14, 915-923 (1988)

15. A Simultaneous Assay by High Performance Liquid Chromato-graphy of Bamipine Hydrochloride and Terbutaline Sulphate in Dosage Forms. J.E. Kountourellis and Catherine Markopoulou. Journal of Liquid Chromatography, 12(16), 3279-3286 (1989)

16. Rapid Isocraric High-Performance Chromatographic Determination of Some Hypnotics/Sedatives in the Presence of Phenytoin in Commercial Formulations. J.E. Kountourellis and C. Markopoulou Indian Drugs, Vol. 27, N° 1, p.p. 66-70 (1989)

17. .Separation and simultaneous determination of bamipine and salbutamol in dosage forms by high-performance liquid chromatography. J.E. Kountourellis, C. Markopoulou and P. Georgakopoulos Journal of Chromatography, 502, 189-192 (1990)

18. RNA Methylation as a Key-Regulatory Process in Growth and Differentiation of Murine Erythroleukemia (MEL) Cells : Inhibition by Í6 - Methyl-adenosine (N6meAdo). J.S. Vizirianakis, C.K. Markopoulou, J.E. Kountourellis, L.C. Papadopoulou and A.S. Tsiftsoglou.

81stAnnual Meeting of the American Association for Cancer Research, Washington DC. Proceedings, Vol. 31, 206( 1990).

19. A HPLC Method for the Separation and Simultaneous Determination of Antihistamines Sympathomimetic Ámines and Dextrome-thorphan in Bulk Drug Material and Dosage Forms. J.E. Kountourellis, C.K. Markopoulou and P.P. Georgakopoulos Analytical Letters, 23 (5), 883-891 (1990).

20. X-Ray Powder Diffraction Data for Nine Analgesics J.E. Kountourellis, C.K. Markopoulou, F.A. Underwood and B. Chapman Talanta 33,2,233-235(1990).

21. A Simultaneous Analysis by High Performance Liquid Chromatography of Bamipine Combined with Tricyclic Antidepressants and/or Antiphychotics in Dosage Forms John E. Kountourellis and Catherine K,. Markopoulou Journal of Liquid Chromatography, 14/15, 2969-2977 (1991) 22. X-Ray Characterization of 12 Diuretics J.E. Kountourellis, C.K. Markopoulou and F.A. Underwood, B.Chapman Journal of Chemical of Engineering Data, 37(2), 187-191, American Chemical Society (1992).

23. X.Ray Powder Diffraction Data for Spironolactone J.E.Kountourellis and C.K. Markopoulou Chemical and Environmental Research 11, 103-105(1992

24. Determination of Vitamin A and E in Therapeutic and Cosmetic Creams Using Solid Phase Extraction (SPE) and High Performance Liquid Chromatograph (HPLC) John E. Kountourellis, Catherine Markopoulou and Byron K. Nathaniel Chem. Environ. Research 1(2) 1992, 83-87

25. Quantitative High Performance Liquid Chromatographic Determination of Bamipine Combined with Tricyclic Antidepressants and/or Antipsychotics in Pharmaceutical Formulations John E. Kountourellis, Catherine K. Markopoulou and John A. Stratis Analytical Letters, 26(10), 2171-2182 (1993)

26. Reversed-Phase High Performance Liquid Chromatographic Determination of Cyproheptadine from Urine by Solid-Phase Extraction John E. Kountourellis*, Kenneth O. Ebete Journal of Chromatography B, 664 (1995) 468-471

27. Separation and Determination of Some Corticosteroids Combined with Bamipine in Pharmaceutical Formulations by High Performance Liquid Chromatography J.E. Kountourellis*, C.K. Markopoulou, K.O. Ebete, and J.A. Stratis Journal of Liquid Chromatography, 18(17), 3507-3517 (1995)

28. Determination of Pimethixene in Plasma and Urine by High Performance Liquid Chromatography J.E. Kountourellis* and K.O. Ebete Analytical Letters, 29(5), 775-784 (1996)

29. Determination of Diphenylpyraline in Plasma and Urine by High- Performance Liquid Chromatography Kenneth O. Ebete, John E. Kountourellis Journal of Chromatography B, 677 (1996) 319-323

30. Rapid and Sensitive Procedure for the Quantitation of Pimethixene in Human Milk and Plasma by Solid Phase Extraction (SPE) Using HPLC K.O. Ebete, J.E. Kountourellis J.Liq. Chrom. & Rel. Technol., 20(5), 789-796 (1997)

31. Isocratic High Performance Liquid Chromatographic Method for the Quantitation of Cyproheptadine in Human Milk and Plasma Using Solvent and Solid Phase Extraction Techniques John E. Kountourellis*, Kenneth O. Ebete, Eleftheria T. Malliou J. Liq. Chrom. & Rel. Technol., 22(4), 603-614 (1999)

32. X-Ray Characterization of 12 Vasolidators in Current Use John E. Kountourellis* and Eleftheria T. Malliou J. Chem. Eng. Data 1999, 44, 656-660

33. High Performance Liquid Chromatographic Determination of Ambroxol in the Presence of Different Preservatives in Pharmaceutical Formulations John E. Koundourellis*, Eleftheria T. Malliou, Theodora A. Broussali Journal of Pharmaceutical and Biomedical Analysis 23(2000) 469-475

34. X-Ray Powder Diffraction Data for 12 Drugs in Current Use John E. Koundourellis* and Eleftheria T. Malliou J. Chem. Eng. Data 2000, 45, 1001-1006

35. Derivative Spectrophotometric and High Performance Liquid Chromato- graphic Determination of Clobutinol in Pharmaceutical Formulations Eleftheria T. Malliou, Constantinos G. Antoniou and John E. Koundourellis Analytical Letters 35(1), 99-109 (2002)

36. FT-IR and Raman Spectroscopic Methods for Identification and Quantitation of Orthorombic and Monoclinic Paracetamol in Powder Mixes Al-Zoubi, J.E. Koundourellis, S. Malamataris Journal of Pharmaceutical and Biomedical Analysis 29(2002) 459-467

37. An Optimized Method for the Simultaneous Determination of Vitamins B1, B6, B12 in Multivitamin Tablets by High Performance Liquid Chromatography C.K. Markopoulou, K.A. Kagkadis, J.E. Koundourellis Journal of Pharmaceutical and Biomedical Analysis 30 (2002) 1403-1410

38. Determination of Butamirate Citrate in Cough Preparations by Derivative UV Spectrophotometry and High Performance Liquid Chromatography Eleftheria T. Malliou, Constantinos G. Antoniou, John E. Koundourellis Analytical Sciences 19 (2003) 563-568