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The Lock-And-Key Analogy in 20Th Century Biochemistry
From: Rebecca Mertens The Construction of Analogy-Based Research Programs The Lock-and-Key Analogy in 20th Century Biochemistry April 2019, 224 p., pb., ill. 34,99 € (DE), 978-3-8376-4442-5 E-Book: PDF: 34,99 € (DE), ISBN 978-3-8394-4442-9 When the German chemist Emil Fischer presented his lock-and-key hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity. Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling. Rebecca Mertens (PhD), born in 1984, is a postdoctoral researcher in the history and philosophy of science at the University of Bielefeld, Germany. She works on the role of analogies, models and forms of comparison in the history of molecular genetics and is a member of the collaborative research program "Practices of ComparisonÚ Ordering and Changing the World". During her graduate and doctoral studies, she was a visiting scholar at the École Normale Supérieure in Paris and a visiting graduate fellow at the Minnesota Center for Philosophy of Science. For further information: www.transcript-verlag.de/en/978-3-8376-4442-5 © 2019 -
Antibodies with Some Bite Antibodies Have Yet to Be Determined, It Is Reasonable to Suppose That the Ester Or David E
-~-------------------------------------N8NSANDVIEWS----------------_N_A_TU_R_E_V-O_L_._32_5_22_J_A_N_U_A_RY__ 19~87 Enzyme catalysis kinetics and is subject to competitive inhibition. Although the detailed chemical mechanisms of these catalytic Antibodies with some bite antibodies have yet to be determined, it is reasonable to suppose that the ester or David E. Hansen carbamate is strained towards a tetra hedral geometry on binding, thus facilitat THE spectacular specificities and rate William Jencks', more directly, stated in ing the attack of the hydroxide ion. Fur enhancements of enzymes are without 1969 thermore, the Scripps group has already equal among all known catalysts. It is no If complementarity between active site and found that their antibody can act via both wonder then that the design of new en transition state contributes significantly to nucleophilic and general base catalysis, zymes has long been a goal of biochemists. enzyme catalysis, it should be possible to syn depending on the substrate used. Now two independent groups, one led by thesize an enzyme by constructing a binding The fact that this approach succeeded at Alfonso Tramontano and Richard Lerner site. One way to do this is to prepare an anti all gives great hope to those attempting to of the Scripps Clinic and Research Foun body to a haptenic group which resembles the isolate even more efficient antibody cat dation', and the other by Peter Schultz of transition state of a given reaction. The com alysts by this and by other strategies. In the University of California at Berkeley\ bining sites of such antibodies should be com addition, it may be possible to modify have taken steps towards this goal by plementary to the transition state and should cause an acceleration by forcing bound sub existing catalytic antibodies. -
CV Sir Arthur Harden
Curriculum Vitae Prof. Dr. Arthur Harden Name: Sir Arthur Harden Lebensdaten: 12. Oktober 1865 ‐ 17. Juni 1940 Arthur Harden war ein britischer Chemiker. Nach ihm sind die Harden‐Young‐Ester (Zuckerphospha‐ te) benannt. Für seine Forschungen über die Gärung von Zucker und dessen Gärungsenzyme wurde er im Jahr 1929 gemeinsam mit dem deutsch‐schwedischen Chemiker Hans von Euler‐Chelpin mit dem Nobelpreis für Chemie ausgezeichnet. Werdegang Arthur Harden studierte von 1882 bis 1885 Chemie am Owens College der University of Manchester. 1868 ging er mit einem Dalton Scholarship an die Universität Erlangen, um beim Chemiker Otto Fi‐ scher, einem Vetter von Emil Fischer (Nobelpreis für Chemie 1902), zu arbeiten. Dort wurde er 1888 promoviert. Im Anschluss arbeitete er als Dozent am Owens College. Ab 1897 war er am neu gegrün‐ deten British Jenner Institute of Preventive Medicine tätig. 1907 wurde er dort Leiter der Abteilung Biochemie. Außerdem erhielt er 1912 eine Professur für Biochemie an der University of London. Auch nach seiner Emeritierung im Jahr 1930 blieb Harden wissenschaftlich aktiv. So befasste er sich unter anderem mit dem Stoffwechsel von E.coli‐Bakterien sowie mit der Gärung. Gemeinsam mit dem deutsch‐schwedischen Wissenschaftler Hans von Euler‐Chelpin gelang es ihm, diesen Vorgang vollständig aufzuklären. Nobelpreis für Chemie 1929 Die Aufklärung der Gärung als eine der ältesten biologischen Technologien der Menschheit hatte bereits zuvor viele Wissenschaftler zu Forschungsarbeiten angeregt, unter ihnen Louis Pasteur und Justus Freiherr von Liebig. Arthur Harden wurde für seine Forschungen über die Gärung von Zucker und die daran beteiligten Gärungsenzyme im Jahr 1929 gemeinsam mit Hans von Euler‐Chelpin mit dem Nobelpreis für Chemie ausgezeichnet. -
A Nobel Synthesis
MILESTONES IN CHEMISTRY Ian Grayson A nobel synthesis IAN GRAYSON Evonik Degussa GmbH, Rodenbacher Chaussee 4, Hanau-Wolfgang, 63457, Germany he first Nobel Prize for chemistry was because it is a scientific challenge, as he awarded in 1901 (to Jacobus van’t Hoff). described in his Nobel lecture: “The synthesis T Up to 2010, the chemistry prize has been of brazilin would have no industrial value; awarded 102 times, to 160 laureates, of whom its biological importance is problematical, only four have been women (1). The most but it is worth while to attempt it for the prominent area for awarding the Nobel Prize sufficient reason that we have no idea how for chemistry has been in organic chemistry, in to accomplish the task” (4). which the Nobel committee includes natural Continuing the list of Nobel Laureates in products, synthesis, catalysis, and polymers. organic synthesis we arrive next at R. B. This amounts to 24 of the prizes. Reading the Woodward. Considered by many the greatest achievements of the earlier organic chemists organic chemist of the 20th century, he who were recipients of the prize, we see that devised syntheses of numerous natural they were drawn to synthesis by the structural Alfred Nobel, 1833-1896 products, including lysergic acid, quinine, analysis and characterisation of natural cortisone and strychnine (Figure 1). 6 compounds. In order to prove the structure conclusively, some In collaboration with Albert Eschenmoser, he achieved the synthesis, even if only a partial synthesis, had to be attempted. It is synthesis of vitamin B12, a mammoth task involving nearly 100 impressive to read of some of the structures which were deduced students and post-docs over many years. -
Timeline of Genomics (1901–1950)*
Research Resource Timeline of Genomics (1901{1950)* Year Event and Theoretical Implication/Extension Reference 1901 Hugo de Vries adopts the term MUTATION to de Vries, H. 1901. Die Mutationstheorie. describe sudden, spontaneous, drastic alterations in Veit, Leipzig, Germany. the hereditary material of Oenothera. Thomas Harrison Montgomery studies sper- 1. Montgomery, T.H. 1898. The spermato- matogenesis in various species of Hemiptera and ¯nds genesis in Pentatoma up to the formation that maternal chromosomes only pair with paternal of the spermatid. Zool. Jahrb. 12: 1-88. chromosomes during meiosis. 2. Montgomery, T.H. 1901. A study of the chromosomes of the germ cells of the Metazoa. Trans. Am. Phil. Soc. 20: 154-236. Clarence Ervin McClung postulates that the so- McClung, C.E. 1901. Notes on the acces- called accessory chromosome (now known as the \X" sory chromosome. Anat. Anz. 20: 220- chromosome) is male determining. 226. Hermann Emil Fischer(1902 Nobel Prize Laure- 1. Fischer, E. and Fourneau, E. 1901. UberÄ ate for Chemistry) and Ernest Fourneau report einige Derivate des Glykocolls. Ber. the synthesis of the ¯rst dipeptide, glycylglycine. In Dtsch. Chem. Ges. 34: 2868-2877. 1902 Fischer introduces the term PEPTIDES. 2. Fischer, E. 1907. Syntheses of polypep- tides. XVII. Ber. Dtsch. Chem. Ges. 40: 1754-1767. 1902 Theodor Boveri and Walter Stanborough Sut- 1. Boveri, T. 1902. UberÄ mehrpolige Mi- ton found the chromosome theory of heredity inde- tosen als Mittel zur Analyse des Zellkerns. pendently. Verh. Phys -med. Ges. WÄurzberg NF 35: 67-90. 2. Boveri, T. 1903. UberÄ die Konstitution der chromatischen Kernsubstanz. Verh. Zool. -
A Tribute to the Memory of Svante Arrhenius (1859-1927)
A TRIBUTE TO THE MEMORY OF SVANTE ArrHENIUS (1859–1927) A SCIENTIst AHEAD OF HIS TIME BY GUstAF A rrHENIUS, K ARIN CALDWELL AND SVANTE WOLD ROYAL SWEDISH ACADEMY OF ENGINEERING SCIENCES (IVA) A TRIBUTE TO THE MEMORY OF SVANTE ARRHENIUS (1859–1927) P RESENTED at THE 2008 A NNUA L MEETING OF THE ROYA L SWEDISH ACA DEM Y OF ENGINEERING SCIENCES BY GUSta F A RRHENIUS, K A RIN CA LDWELL A ND SVA NTE WOLD The Royal Swedish Academy of Engineering Sciences (IVA) is an independent, learned society that promotes the engineering and economic sciences and the development of industry for the benefit of Swedish society. In cooperation with the business and academic communities, the Academy initiates and proposes measures designed to strengthen Sweden’s industrial skills base and competitiveness. For further information, please visit IVA’s website at www.iva.se. Published by the Royal Swedish Academy of Engineering Sciences (IVA) and Gustaf Arrhenius, Scripps Institution of Oceanography, University of California, San Diego, Karin Caldwell, Surface Biotechnology, Uppsala University and Svante Wold, Umetrics AB and Institute of Chemistry, Umeå University. Cover picture: photography of original painting by Richard Bergh, 1910. Photos and illustrations provided by the authors and by courtesy of the archives at the Royal Swedish Academy of Sciences. The authors would like to express their gratitude to professor Henning Rodhe at Stockholm University for his comments and contributions on selected text. IVA, P.O. Box 5073, SE-102 42 Stockholm, Sweden Phone: +46 8 791 29 00 Fax: +46 8 611 56 23 E-mail: [email protected] Website: www.iva.se IVA-M 395 • ISSN 1102-8254 • ISBN 978-91-7082-779-2 Editor: Eva Stattin, IVA Layout and production: Hans Melcherson, Tryckfaktorn AB, Stockholm, Sweden Printed by OH-Tryck, Stockholm, Sweden, 2008 FOREWORD Every year, the Royal Academy of Engineering Sciences (IVA) produces a booklet com- memorating a person whose scientific, engineering, economic or industrial achieve- ments were of significant benefit to the society of his or her day. -
Hermann Emil Fischer: Life and Achievements
GENERAL ARTICLE Hermann Emil Fischer: Life and Achievements G Nagendrappa Emil Fischer, considered as one of the greatest chemists of all times, carried out much of the fundamental work on purines, sugars, proteins, stereochemistry and several other areas of chemistry during the late nineteenth and early twentieth century. Because most of these are biological molecules, he is known as the ‘Father of Biochemistry’. His achievements in G Nagendrappa was a Professor of Organic chemical synthesis and analytical skills were much ahead of Chemistry at Bangalore his times. He was the second to get the Nobel Prize in Chem- University, and Head of istry in 1902. the Department of Medicinal Chemistry, Sri Introduction Ramachandra (Medical) University, Chennai. He is Carbohydrates, proteins, fats, and nucleic acids are the four major currently in Jain Univer- sity, Bangalore. He chemical constituents of living organisms. These four classes of continues to teach and do organic compounds are the main players in the emergence and research. His work is in existence of life. Extensive pioneering contributions to the devel- the area of organosilicon opment of all these areas of organic chemistry and biochemistry chemistry, synthetic and mechanistic organic were made by Emil Fischer through his more than four decades of chemistry, and clay- brilliant research work starting from the early 1870s. His uncanny catalysed organic reactions skills in analytical and synthetic work, his extraordinary under- (Green Chemistry). standing of the enormous amount of experimental results and their correct interpretation laid a solid foundation for the chemis- try of these biologically important molecules. Though his work essentially constituted analytical and synthetic organic chemis- try, its reach extended to other areas, particularly stereochemis- try, biochemistry, physiology and medicine. -
Book Review Robert Burns Woodward: Architect and Artist in the World of Molecules by Otto Theodor Benfey and Peter J
Book Review Robert Burns Woodward: Architect and Artist in the World of Molecules by Otto Theodor Benfey and Peter J. T. Morris, Eds. (Chemical Heritage Foundation, 2001) 470 pp., ISBN: 0941901254; $45.00 (hard cover) Reviewed by Bernard Miller, Department of Chemistry, University of Massachusetts, Amherst The structure known, but not yet accessible by synthesis, is to the chemist what the unclimbed mountain, the uncharted sea, the untilled field, the unreached planet, are to other men ... The unique challenge which chemical synthesis provides for the creative imagination and the skilled hand ensures that it will endure as long as men write books, paint pictures, and fashion things which are beautiful, or practical, or both. Robert Burns Woodward* It is fitting that this stirring description of the beauty of organic synthesis should come from the pen of the greatest practitioner of the art in our time - perhaps the greatest (in competition with Emil Fischer and Sir Robert Robinson) of all time. Certainly, Robert Burns Woodward was known not only for the remarkable work carried out in his laboratory, but for the clarity, precision, and elegance of his reports of that work. His lectures, frequently featuring complex structures drawn by hand in chalk of many colors, put the usual lecturer’s parade of slides to shame. (Indeed, Woodward seemed to resist the use of mechanical presentation aids as long as possible. As the last of the chalk-talkers, I rely on his example to support my own contention that the human mind works at the same rate as a piece of chalk on a blackboard.) Several of Woodward’s lectures are included in this Festschrift, including his lectures accepting the Nobel prize and the Cope medal, as well as a transcript of his lecture, presented in Sheffield, England, on the Woodward-Hoffmann rules. -
Nobel Prize Awards in Radiochemistry
Radiochim. Acta 100, 509–521 (2012) / DOI 10.1524/ract.2012.1953 © by Oldenbourg Wissenschaftsverlag, München Nobel Prize awards in Radiochemistry By J.-P. Adloff∗ University of Strasbourg, 63 Rue Saint Urbain, 67100 Strasbourg, France Dedicated to the memory of late Karl H. Lieser, Gerhard L. Stöcklin and Alfred P. Wolf with whom the author shared the editorial work of Radiochimica Acta from 1977 to 1995 (Received October 10, 2011; accepted in revised form January 19, 2012) (Published online March 26, 2012) Nobel Prize / Chemistry / Physics Summary. In 1996 the Editors of Radiochimica Acta brought out a special volume of the journal to celebrate the hundredth anniversary of the discovery of radioactivity [1]. On the occasion of the 50th anniversary of Radiochimica Acta, which follows closely upon the centenary of Marie Curie’s second Nobel Prize in 1911, the author has the privilege to informally review “Radiochemistry and Nobel Prize Awards”, including discoveries of radioelements and new fields in chemistry based on radiochemical methods. 1. The beginning The Nobel Prizes in Physics and Chemistry were estab- lished in 1901, six years after the discovery of radioactivity and three years after the discoveries of the elements polo- Fig. 1. Antoine Henri Becquerel (1852–1908). nium and radium. They are awarded by Kungliga Veten- skapakademien (the Royal Swedish Academy of Sciences) on the basis of proposals made by respective Committees rays when he thought the subject was exhausted. By the end on Physics and Chemistry, which receive recommendations of 1897 radioactivity was something of a dead horse: it was from Swedish and foreign scientists [2]. -
Eminent Chemists of Our Time
EMINENT CHEMISTS O F O UR TIME E M N H B NJA I HARROW, P . D . Associate in Physiological Ch emistry ILL US TRATED W M NEW YORK D . V A N N O S T R A N D C O M P A N Y EIGHT WARRE N S TREET PREFACE We have several books deal ing with the history of chemistry ; there are a number of biographies of pioneer — l chemists ; but, so far a s I am aware and this inc udes books in French and German as well a s in English l the chemists of our time have been ignored complete y . The Dickenses and Thackerays of chemistry have — l received attention not any too much , to be sure ; but m ll the odem s , the Anatole Frances and We s, have received none . H To fill such a want is the object of this work . ow much these men and woman who are here treated are of our time may be gauged from the following : of the eleven whose lives and work are discussed, one died in 1 897 (through suicide , be it a dded) ; three , in 1 90 7 ; 1 1 1 one , in 9 1 ; one , in 1 91 6 ; one , in 1 9 9 ; and four are The question may very naturally be a sked , why were just these eleven selected? To this I would answer, that, with the historical perspective in mind , I wished to review the achievements of those men whose work is indissolubly bound up with the progress of chemistry la o during the st generation or so . -
Emil Fischer Papers, 1876-1919
http://oac.cdlib.org/findaid/ark:/13030/tf6000053v No online items Finding Aid to the Emil Fischer Papers, 1876-1919 Processed by The Bancroft Library staff The Bancroft Library. University of California, Berkeley Berkeley, California, 94720-6000 Phone: (510) 642-6481 Fax: (510) 642-7589 Email: [email protected] URL: http://bancroft.berkeley.edu © 1996 The Regents of the University of California. All rights reserved. Note This finding aid has been fimed for the National Inventory of Documentary Sources in the United States (Chadwyck-Healey Inc.) Finding Aid to the Emil Fischer BANC MSS 71/95 z 1 Papers, 1876-1919 Finding Aid to the Emil Fischer Papers, 1876-1919 Collection number: BANC MSS 71/95 z The Bancroft Library University of California, Berkeley Berkeley, California Contact Information: The Bancroft Library. University of California, Berkeley Berkeley, California, 94720-6000 Phone: (510) 642-6481 Fax: (510) 642-7589 Email: [email protected] URL: http://bancroft.berkeley.edu Processed by: The Bancroft Library staff Date Completed: ca. 1971 Encoded by: Xiuzhi Zhou © 1996 The Regents of the University of California. All rights reserved. Collection Summary Collection Title: Emil Fischer Papers, Date (inclusive): 1876-1919 Collection Number: BANC MSS 71/95 z Creator: Fischer, Emil, 1852-1919 Extent: Number of containers: 39 boxes, 12 cartons, 7 oversize folders, 15 oversize volumes Repository: The Bancroft Library Berkeley, California 94720-6000 Physical Location: For current information on the location of these materials, please consult the Library's online catalog. Abstract: Correspondence; manuscripts, including drafts of his autobiography; reprints of his writings; subject files relating to his research and to work during World War I, and to professional activities; laboratory notebooks, his own and those of his students; clippings; photographs; and certificates of election or appointment to scientific societies. -
Nobel Prizes List from 1901
Nature and Science, 4(3), 2006, Ma, Nobel Prizes Nobel Prizes from 1901 Ma Hongbao East Lansing, Michigan, USA, Email: [email protected] The Nobel Prizes were set up by the final will of Alfred Nobel, a Swedish chemist, industrialist, and the inventor of dynamite on November 27, 1895 at the Swedish-Norwegian Club in Paris, which are awarding to people and organizations who have done outstanding research, invented groundbreaking techniques or equipment, or made outstanding contributions to society. The Nobel Prizes are generally awarded annually in the categories as following: 1. Chemistry, decided by the Royal Swedish Academy of Sciences 2. Economics, decided by the Royal Swedish Academy of Sciences 3. Literature, decided by the Swedish Academy 4. Peace, decided by the Norwegian Nobel Committee, appointed by the Norwegian Parliament, Stortinget 5. Physics, decided by the Royal Swedish Academy of Sciences 6. Physiology or Medicine, decided by Karolinska Institutet Nobel Prizes are widely regarded as the highest prize in the world today. As of November 2005, a total of 776 Nobel Prizes have been awarded, 758 to individuals and 18 to organizations. [Nature and Science. 2006;4(3):86- 94]. I. List of All Nobel Prize Winners (1901 – 2005): 31. Physics, Philipp Lenard 32. 1906 - Chemistry, Henri Moissan 1. 1901 - Chemistry, Jacobus H. van 't Hoff 33. Literature, Giosuè Carducci 2. Literature, Sully Prudhomme 34. Medicine, Camillo Golgi 3. Medicine, Emil von Behring 35. Medicine, Santiago Ramón y Cajal 4. Peace, Henry Dunant 36. Peace, Theodore Roosevelt 5. Peace, Frédéric Passy 37. Physics, J.J. Thomson 6. Physics, Wilhelm Conrad Röntgen 38.