Nobel Laureates in Chemistry 1901-1992
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Peter P. T. Sah and the Synthesis of Vitamin C in China and Europe
EASTM 20 (2003 ): 92-98 Peter P. T. Sah and the Synthesis of Vitamin C in China and Europe Zhang Li [Zhang Li is Associate Professor at the Institute for the History of Natural Sci ence, Chinese Academy of Sciences. She has published a number of articles on the history of modern chemistry of both the West and China and the social his tory of science in twentieth-century China, including studies on the influence of higher education reform on chemical education in the 1950s in China (1992) and the coordination between national needs and scientists' autonomy during 1949-/965 (2003). She recently received her doctoral degree in the Philosophy of Science from Peking University, completing a dissertation on the institution alization of science in the People's Republic of China. Her forthcoming book is called Gaofenzi kexue zai Zhongguo de jianli ( 1949-1965) r%'J 5t r f-4 ~ ft i:p 00 R"J ~ JI. (1949-1965) ( Institutionalization of Polymer Science in China(l949- /965) Jinan: Shandong jiaoyu chubanshe 2003, ¥ff 1¥i : W J'.f: ¥!I.. W tB It& ffr±, 2003).J * * * The synthesis of vitamin C was one of the main scientific achievements in the 1930s. Many scientists in Europe made contributions to this field, especially Albert Szent-Gyorgyi (1893-1986) from Hungary and Sir Walter Norman Ha worth ( 1883-1950) from England, both of whom won the Nobel Prize in 1937. In the same period, a Chinese chemist, Sa Bentie ~ :;$: ~ (1900-1986), better known outside China as Peter P. T. Sah, was also studying vitamin C. -
Perspectives on Supercomputing and Artificial Intelligence Applications In
DOI: 10.14529/jsfi200302 Perspectives on Supercomputing and Artificial Intelligence Applications in Drug Discovery Jun Xu1,2, Jiming Ye1 c The Authors 2020. This paper is published with open access at SuperFri.org This review starts with outlining how science and technology evaluated from last century into high throughput science and technology in modern era due to the Nobel-Prize-level inventions of combinatorial chemistry, polymerase chain reaction, and high-throughput screening. The evolu- tion results in big data accumulated in life sciences and the fields of drug discovery. The big data demands for supercomputing in biology and medicine, although the computing complexity is still a grand challenge for sophisticated biosystems in drug design in this supercomputing era. In or- der to resolve the real-world issues, artificial intelligence algorithms (specifically machine learning approaches) were introduced, and have demonstrated the power in discovering structure-activity relations hidden in big biochemical data. Particularly, this review summarizes on how people mod- ernize the conventional machine learning algorithms by combing non-numeric pattern recognition and deep learning algorithms, and successfully resolved drug design and high throughput screening issues. The review ends with the perspectives on computational opportunities and challenges in drug discovery by introducing new drug design principles and modeling the process of packing DNA with histones in micrometer scale space, an example of how a macrocosm object gets into microcosm world. Keywords: drug discovery, big data, artificial intelligence, HPC. 1. Big Data and Supercomputing Challenges in Drug Discovery In the last century, three cutting-edge inventions, which were combinatorial chemistry (CC), polymerase chain reaction (PCR), and high-throughput screening (HTS), significantly changed biomedical science and technology. -
The Lock-And-Key Analogy in 20Th Century Biochemistry
From: Rebecca Mertens The Construction of Analogy-Based Research Programs The Lock-and-Key Analogy in 20th Century Biochemistry April 2019, 224 p., pb., ill. 34,99 € (DE), 978-3-8376-4442-5 E-Book: PDF: 34,99 € (DE), ISBN 978-3-8394-4442-9 When the German chemist Emil Fischer presented his lock-and-key hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity. Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling. Rebecca Mertens (PhD), born in 1984, is a postdoctoral researcher in the history and philosophy of science at the University of Bielefeld, Germany. She works on the role of analogies, models and forms of comparison in the history of molecular genetics and is a member of the collaborative research program "Practices of ComparisonÚ Ordering and Changing the World". During her graduate and doctoral studies, she was a visiting scholar at the École Normale Supérieure in Paris and a visiting graduate fellow at the Minnesota Center for Philosophy of Science. For further information: www.transcript-verlag.de/en/978-3-8376-4442-5 © 2019 -
Biochemistrystanford00kornrich.Pdf
University of California Berkeley Regional Oral History Office University of California The Bancroft Library Berkeley, California Program in the History of the Biosciences and Biotechnology Arthur Kornberg, M.D. BIOCHEMISTRY AT STANFORD, BIOTECHNOLOGY AT DNAX With an Introduction by Joshua Lederberg Interviews Conducted by Sally Smith Hughes, Ph.D. in 1997 Copyright 1998 by The Regents of the University of California Since 1954 the Regional Oral History Office has been interviewing leading participants in or well-placed witnesses to major events in the development of Northern California, the West, and the Nation. Oral history is a method of collecting historical information through tape-recorded interviews between a narrator with firsthand knowledge of historically significant events and a well- informed interviewer, with the goal of preserving substantive additions to the historical record. The tape recording is transcribed, lightly edited for continuity and clarity, and reviewed by the interviewee. The corrected manuscript is indexed, bound with photographs and illustrative materials, and placed in The Bancroft Library at the University of California, Berkeley, and in other research collections for scholarly use. Because it is primary material, oral history is not intended to present the final, verified, or complete narrative of events. It is a spoken account, offered by the interviewee in response to questioning, and as such it is reflective, partisan, deeply involved, and irreplaceable. ************************************ All uses of this manuscript are covered by a legal agreement between The Regents of the University of California and Arthur Kornberg, M.D., dated June 18, 1997. The manuscript is thereby made available for research purposes. All literary rights in the manuscript, including the right to publish, are reserved to The Bancroft Library of the University of California, Berkeley. -
Curriculum Vitae Prof. Dr. Adolf Otto Reinhold Windaus
Curriculum Vitae Prof. Dr. Adolf Otto Reinhold Windaus Name: Adolf Otto Reinhold Windaus Lebensdaten: 25. Dezember 1876 - 9. Juni 1956 Adolf Windaus war ein deutscher Chemiker. Er untersuchte Naturstoffe, vor allem die biochemisch wichtigen Sterine und ihren Zusammenhang mit anderen Naturstoffen. Er entdeckte die chemische Verwandtschaft von Cholesterin und Gallensäure. Außerdem lieferte er Arbeiten über Vitamine, vor allem das Vitamin D. Zwischen 1927 und 1931 gelang ihm die Isolierung mehrerer D-Vitamine. Seine Forschungen bildeten die Grundlage für später von seinen Schülern durchgeführten Arbeiten über die menschlichen Sexualhormone. Für seine Verdienste um die Erforschung des Aufbaus der Sterine und ihres Zusammenhangs mit den Vitaminen wurde Adolf Windaus 1928 mit dem Nobelpreis für Chemie ausgezeichnet. Akademischer und beruflicher Werdegang Adolf Windaus begann 1895 ein Studium der Medizin an der Universität Freiburg. Er wechselte nach Berlin, wo er 1897 das Physikum bestand. 1899 wurde er in Freiburg mit einer Arbeit über Neue Beiträge zur Kenntnis der Digitalisstoffe promoviert wurde. 1901 war er zunächst in Berlin als Assistent von Emil Fischer (Nobelpreis für Chemie 1902) tätig. Während dieser Zeit wandte er sich zunehmend chemischen Fragestellungen zu. Außerdem begann er mit seinen Forschungen zu den Sterinen. 1903 habilitierte er sich in Freiburg mit einer Arbeit über Cholesterin. 1906 erhielt er eine außerordentliche Professur an der Universität Göttingen. Im Anschluss wechselte er für zwei Jahre an die Universität Innsbruck, wo er eine außerordentliche Professur für angewandte medizinische Chemie erhielt. 1915 ging er zurück nach Göttingen, wo er als Nachfolger von Otto Wallach (Nobelpreis für Chemie 1910) Ordinarius für Chemie wurde. Dort blieb er bis zu seiner Emeritierung im Jahr 1944. -
Gã¼nther Ohloff ÂŒ Chemist & Pioneer in the Art
BIRTHDAY 65 CHIMIA 2004, 58, No. 1/2 Chimia 58 (2004) 65–66 © Schweizerische Chemische Gesellschaft ISSN 0009–4293 Günther Ohloff – Chemist & Pioneer in the Art of Perfumery On the Occasion of his 80th Birthday Wolfgang Giersch, Gerald Uhde, and Ferdinand Näf* Keywords: Ohloff, G. With a first degree in pharmacy, he then It was during this period that he devel- studied chemistry at the Technische Hoch- oped his research interests for the chemistry schule Dresden where he received his diplo- of perfumery extracts from animal sources, ma with a thesis entitled ‘Chemical Investi- in particular amber and musk type ingredi- gation of Turpentine Oil of Silvester Pine ents, and which led to Ambropur®, Lac- (Pinus Silvestris L.)’.After followed a Ph.D. toskaton® and Isobergamiat® as commer- in 1951 under Professor Heinrich Wienhaus cial products. for a dissertation entitled ‘The Condensa- Already during his early days as a phar- tion of Terpenes with Formaldehyde’. macist, and through his whole life he He then decided to move into industry: showed lively interest in the potential phys- Schimmel & Co, Miltitz near Leipzig, iological activities of odorants. In 1956 a which had been the largest perfume manu- study about the aphrodisiac effects of his facturer in the world up to World War I. Ambropur® was published [1]. One of the The exposure in his young days to the reported investigations concerned a 54 year constituents of essential oils, especially under old opera singer suffering from Parkinson’s Prof. Heinrich Wienhaus’ guidance, one of disease and a strongly impaired libido. Af- Prof. Otto Wallach’s last students, influenced ter Ambropur® had been administered to him throughout his scientific career. -
Interview with Linus Pauling
LINUS PAULING (1901-1994) INTERVIEWED BY JOHN L. GREENBERG May 10, 1984 Photo by M. Opalenik c. 1964 ARCHIVES CALIFORNIA INSTITUTE OF TECHNOLOGY Pasadena, California Subject area Chemistry Abstract Interview in 1984 with Linus Pauling, professor of chemistry emeritus. He recalls his instructorship in quantitative analysis at Oregon Agricultural College at age 18. To Caltech for graduate study, 1922. As preparation, Arthur Amos Noyes sent him proof sheets of Noyes’s new book, Chemical Principles. Studied X-ray crystallography with Roscoe G. Dickinson. Gave seminar on Debye-Hückel theory of electrolytic solutions for visiting P. J. W. Debye. Recollections of Noyes (then chairman of the Division of Chemistry and Chemical Engineering), Dickinson, and Ralph W. G. Wyckoff. Discusses X-ray crystallography and its history. Recollections of Gilbert N. Lewis, Caltech’s rivalry with Berkeley. Paper with Richard C. Tolman on residual entropy of crystals; recalls courses with Tolman. Offer of professorship at Harvard in 1929 and MIT c. 1930. Death of Noyes (1936) and Pauling’s appointment as chairman of chemistry division (1937). Remarks on Biology Division and advent of Thomas Hunt Morgan (1928). Work on hemoglobin in mid-1930s. Remarks on Karl Landsteiner and immunology. Lectures on “complementariness” as basis of biological specificity; paper with Max Delbrück. Projected book on the molecular basis of biological specificity, to be called The Nature of Life. Recollections of Albert Tyler and http://resolver.caltech.edu/CaltechOH:OH_Pauling_L George W. Beadle. Comments on relations with Warren Weaver and Rockefeller Foundation. Discusses work on protein structure and discovery of alpha helix. Discusses his reasons for leaving Caltech in 1963 and the attitude of Caltech president Lee DuBridge and John Roberts, then chair of the chemistry division. -
Peptide Chemistry up to Its Present State
Appendix In this Appendix biographical sketches are compiled of many scientists who have made notable contributions to the development of peptide chemistry up to its present state. We have tried to consider names mainly connected with important events during the earlier periods of peptide history, but could not include all authors mentioned in the text of this book. This is particularly true for the more recent decades when the number of peptide chemists and biologists increased to such an extent that their enumeration would have gone beyond the scope of this Appendix. 250 Appendix Plate 8. Emil Abderhalden (1877-1950), Photo Plate 9. S. Akabori Leopoldina, Halle J Plate 10. Ernst Bayer Plate 11. Karel Blaha (1926-1988) Appendix 251 Plate 12. Max Brenner Plate 13. Hans Brockmann (1903-1988) Plate 14. Victor Bruckner (1900- 1980) Plate 15. Pehr V. Edman (1916- 1977) 252 Appendix Plate 16. Lyman C. Craig (1906-1974) Plate 17. Vittorio Erspamer Plate 18. Joseph S. Fruton, Biochemist and Historian Appendix 253 Plate 19. Rolf Geiger (1923-1988) Plate 20. Wolfgang Konig Plate 21. Dorothy Hodgkins Plate. 22. Franz Hofmeister (1850-1922), (Fischer, biograph. Lexikon) 254 Appendix Plate 23. The picture shows the late Professor 1.E. Jorpes (r.j and Professor V. Mutt during their favorite pastime in the archipelago on the Baltic near Stockholm Plate 24. Ephraim Katchalski (Katzir) Plate 25. Abraham Patchornik Appendix 255 Plate 26. P.G. Katsoyannis Plate 27. George W. Kenner (1922-1978) Plate 28. Edger Lederer (1908- 1988) Plate 29. Hennann Leuchs (1879-1945) 256 Appendix Plate 30. Choh Hao Li (1913-1987) Plate 31. -
"But She's an Avowed Communist!" L'affaire Curie at the American Chemical Society, 1953-1955
ll. t. Ch. 20 ( 33 "BUT SHE'S AN AVOWED COMMUNIST!" L'AFFAIRE CURIE AT THE AMERICAN CHEMICAL SOCIETY, 1953-1955 Mrrt W. tr, Crnll Unvrt Intrdtn On ht hv xptd tht th Arn Chl St (ACS, n rnztn tht ld t b r n fr th dvnnt f htr nd nt n p ltl tt fr t brhp, ld rdl pt n ppltn fr bl lrt n htr. Yt th nt th th Irèn ltCr n . Aftr ntrntn ACS ffl rjtd hr brhp ppltn b f hr pltl rpttn (trnl lnd t th prCnt blf nd tvt f hr hbnd, rdr ltCr, nfrd hr f th dn bt v n rn, nd d nth n f thr tn pbll. Whn nth ltr hr frnd tnd nd pblzd hr rjtn, th b lèbr. h xtnv ntr nd rrpndn rrndn th pd t p bl t ntprr rtn t th d, hndln, nd nfn f th dn. Whn prd t n f th thr ntnt "th hnt" n th Untd Stt n th 40 nd 0, th pbl hrnt f ldn br f th Ar n Atn fr th Advnnt f Sn (AAAS, n n th dffrnt rtn. Whr th AAAS brd f drtr rpndd ttl t th ntnt rd b ltn E. U. Cndn nd Figure. 1 Irene Joliot-Curie (1897-1956). Shown here Krtl Mthr prdnt (, th ldr f th ACS late in life, Joliot-Curie shared the Nobel Prize in rfd t lt Md ltCr vn t br Chemistry with her husband Frederic in 1935. hp. "Affr Cr," t t b lld, l Intensely apolitical in her early life, she became more rvld trtrl tnn thn th ACS btn involved in French women's, socialist, and pro- th prttv ntnt f th br f th rd f Communist movements starting in the late 1930s. -
Antibodies with Some Bite Antibodies Have Yet to Be Determined, It Is Reasonable to Suppose That the Ester Or David E
-~-------------------------------------N8NSANDVIEWS----------------_N_A_TU_R_E_V-O_L_._32_5_22_J_A_N_U_A_RY__ 19~87 Enzyme catalysis kinetics and is subject to competitive inhibition. Although the detailed chemical mechanisms of these catalytic Antibodies with some bite antibodies have yet to be determined, it is reasonable to suppose that the ester or David E. Hansen carbamate is strained towards a tetra hedral geometry on binding, thus facilitat THE spectacular specificities and rate William Jencks', more directly, stated in ing the attack of the hydroxide ion. Fur enhancements of enzymes are without 1969 thermore, the Scripps group has already equal among all known catalysts. It is no If complementarity between active site and found that their antibody can act via both wonder then that the design of new en transition state contributes significantly to nucleophilic and general base catalysis, zymes has long been a goal of biochemists. enzyme catalysis, it should be possible to syn depending on the substrate used. Now two independent groups, one led by thesize an enzyme by constructing a binding The fact that this approach succeeded at Alfonso Tramontano and Richard Lerner site. One way to do this is to prepare an anti all gives great hope to those attempting to of the Scripps Clinic and Research Foun body to a haptenic group which resembles the isolate even more efficient antibody cat dation', and the other by Peter Schultz of transition state of a given reaction. The com alysts by this and by other strategies. In the University of California at Berkeley\ bining sites of such antibodies should be com addition, it may be possible to modify have taken steps towards this goal by plementary to the transition state and should cause an acceleration by forcing bound sub existing catalytic antibodies. -
William S. Johnson
William S. Johnson February 24, 1913 - August 19, 1995 William S, Johnson was a highly respected leader among research chemists and educators while, at the same time, he was humble about his accomplishments. His career spanned an explosive period of rapid progress in science and he was at the cutting edge of many of the basic changes that have taken place. His deep respect and love for science led to a career that was characterized by creative, insightful and thorough research and resulted in a body of work on steroid synthesis that is unparalleled for its thorough comprehensive coverage. Bill Johnson did his undergraduate studies at Amherst College, an institution that has spawned a number of chemical leaders. After finishing his doctoral work with Professor Louis Fieser at Harvard University in late 1939 and a brief postdoctoral stint at Harvard with Professor R.P. Linstead, Johnson began his independent academic career at the University of Wisconsin in 1940. The research program that Johnson initiated was directed at the development of methodology for the synthesis of steroids. While the approaches would change over the years, this theme would become the dominant direction for Bill Johnson's research effort over his entire academic career. The "Wisconsin era" was devoted to a classical approach to the total synthesis of the steroid skeleton and resulted in the development of the benzylidene blocking group for the angular methylation of a-decalone type molecules, the use of the Stobbe reaction for the synthesis of the aromatic steroids equilenin and estrone, and the "hydrochrysene approach" to the total synthesis of nonaromatic steroids. -
SCIENCE HISTORY INSTITUTE ISABELLA KARLE and JEROME
SCIENCE HISTORY INSTITUTE ISABELLA KARLE and JEROME KARLE Transcript of an Interview Conducted by James J. Bohning and David K. Van Keuren at Naval Research Laboratory Washington, District of Columbia on 26 February, 15 June and 9 September 1987 (With Subsequent Corrections and Additions) Upon Isabella Karle’s death in 2017, this oral history was designated Free Access. Please note: This oral history is protected by U.S. copyright law and shall not be reproduced or disseminated in any way without the express permission of the Science History Institute. Users citing this interview for purposes of publication are obliged under the terms of the Center for Oral History, Science History Institute, to credit the Science History Institute using the format below: Isabella Karle and Jerome Karle, interview by James J. Bohning and David K. Van Keuren at Naval Research Laboratory, Washington, District of Columbia, 26 February, 15 June and 9 September 1987 (Philadelphia: Science History Institute, Oral History Transcript # 0066). Formed by the merger of the Chemical Heritage Foundation and the Life Sciences Foundation, the Science History Institute collects and shares the stories of innovators and of discoveries that shape our lives. We preserve and interpret the history of chemistry, chemical engineering, and the life sciences. Headquartered in Philadelphia, with offices in California and Europe, the Institute houses an archive and a library for historians and researchers, a fellowship program for visiting scholars from around the globe, a community of researchers who examine historical and contemporary issues, and an acclaimed museum that is free and open to the public. For more information visit sciencehistory.org.