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The European Peptide Society Newsletter
THE EUROPEAN PEPTIDE SOCIETY NEWSLETTER ISSUE NUMBER 45, JANUARY 2012 John M. Stewart (1924–2011) Polish Peptide Symposium Peptide Meeting of the Hungarian Academy of Sciences Bulgarian Peptide Symposium Published by the Journal of Peptide Science The Official Journal of the European Peptide Society A Message from the Chairman of the 32nd EPS Symposium Cover photo: Parthenon, Acropolis of Athens: venue of the forthcoming 32nd European Peptide Symposium Dear Colleagues, IN THIS ISSUE A Message from the Chairman of the 32 EPS . .2 n behalf of the Organising surprises. The history of Athens is one of Chemistry and Biology Committee, we have the pleasure the longest of any city in Europe and in of Peptides . .3 Oof inviting you to the 32nd the world. Three thousand years old Polish Peptide Symposium . .4 European Peptide Symposium (32EPS cultural riches are housed in Hungarian Peptide Meeting . .6 Bulgarian Peptide Symposium .8 2012), which will be held in Athens from approximately 50 national and private Austrian Peptide Symposium .10 the 2nd to the 7th September, 2012. museums, including the new Acropolis Doctorate Honoris Causa to The symposium will present the most museum, featuring from neolithic L. Moroder . .12 recent, cutting-edge research on a broad settlement finds to examples of modern John M. Stewart, in Memoriam . .14 range of topics in the area of Peptide art. When you are in Athens you will Book Review . .17 Science by leading international experts probably get the impression the city never Society News . .19 from both industry and academia. The sleeps. It is our intention to establish an Society Officers . -
Els Premis Nobel De L'any 2008
ELS PREMIS NOBEL DE L’ANY 2008 SOBRE EL PREMI NOBEL DE QUÍMICA CONCEDIT A OSAMU SHIMOMURA, MARTIN CHALFIE I ROGER Y. TSIEN, A CÀRREC D’ERNEST GIRALT, DE L’INSTITUT DE RECERCA BIOMÈDICA (PARC CIENTÍFIC DE BARCELONA) I EL DEPARTAMENT DE QUÍMICA ORGÀNICA DE LA UNIVERSITAT DE BARCELONA 001-154 Premis Nobel 2008.indd 31 16/02/2016 08:29:03 LA PROTEÏNA FLUORESCENT VERDA RESUM L’any 2008, els guanyadors del Premi Nobel de Química han estat el japonès Osamu Shimomura i els nord-americans Mar- tin Chalfie i Roger Y. Tsien. En paraules de la Reial Acadèmia Sueca de Ciències, han guanyat el premi «pel descobriment i el desenvolupament de la proteïna fluorescent verda». La pro- teïna fluorescent verda (o GFP, de l’anglès green fluorescent protein) és un compost de massa molecular de 26.900 que es caracteritza per la seva intensa fluorescència verda (509 nm) quan s’il·lumina amb llum violada (395 nm). Va ser aïllada inicialment de la medusa Aequorea victoria, un hidroïdeu de les aigües costaneres del Pacífic nord-americà, i posterior- ment s’ha trobat en altres organismes. La proteïna fluorescent 32 verda està formada per 238 aminoàcids. La seva fluorescència és deguda a la formació de diversos enllaços covalents entre les cadenes laterals d’alguns d’aquests aminoàcids. És un fe- nomen espontani, que es coneix amb molta precisió, raó per la qual ha estat possible preparar variants de la GFP que emeten fluorescència en una àmplia gamma cromàtica. La importàn- cia de la proteïna fluorescent verda rau en la seva utilitat com a marcador en l’estudi de processos biològics. -
The Ucla Medal Recipients, 1979 - Present (Chronological)
THE UCLA MEDAL RECIPIENTS, 1979 - PRESENT (CHRONOLOGICAL) 1979 Special Ceremony, Golden Year Celebration, September 16, 1979 William Coit Ackerman ’24, UCLA pioneer, coach John E. Canaday ’27, former president, UCLA Alumni Association, UC regent 1980 Special Ceremony, Charter Day, March 2, 1980 J.D. Morgan ’41, director, Intercollegiate Athletics Commencement, June 15, 1980 Gordon H. Ball, professor, zoology Joseph Kaplan, professor, geophysics Earl J. Miller, professor, economics Flora Murray Scott, professor, botanical sciences Marion A. Zeitlin, professor, Spanish Special Ceremony, Reception in Honor of Byron Atkinson, September 29, 1980 Byron Harry Atkinson ’40, M.A. ’50, Ed.D. ’60, administrator 1981 Commencement, June 21, 1981 Warren Minor Christopher, attorney and diplomat Shirley Ann Mount Hufstedler, attorney and judge William Polk Longmire, Jr., founder, UCLA department of surgery 1982 Commencement, June 20, 1982 Simon Ramo, co-founder of TRW Richard Callender Maxwell, former dean, UCLA School of Law Dorothy Buffum Chandler, arts patron and UC regent 1983 Commencement, June 19, 1983 Tom Bradley ’41, mayor, City of Los Angeles Elinor Raas Heller, UC regent Laurence Olivier, actor David Stephen Saxon, president emeritus, University of California 1984 Commencement, June 17, 1984 Anna Bing Arnold ’40, philanthropist and humanist Franklin David Murphy, UCLA chancellor emeritus Isaac Bashevis Singer, author and Nobel Prize recipient 1985 Commencement, June 16, 1985 Carol Burnett ’54, actress Edward William Carter ’32, businessman and UC regent John Robert Wooden, former UCLA men's basketball coach Page 1 of 10 UCLA Special Events and Protocol • 10920 Wilshire Boulevard, Suite 1520 • Los Angeles, CA 90024 THE UCLA MEDAL RECIPIENTS, 1979 - PRESENT (CHRONOLOGICAL) 1986 Commencement, June 22, 1986 Robert Howard Ahmanson ’49, president, Ahmanson Foundation John Hope Franklin, historian William W. -
Federation Member Society Nobel Laureates
FEDERATION MEMBER SOCIETY NOBEL LAUREATES For achievements in Chemistry, Physiology/Medicine, and PHysics. Award Winners announced annually in October. Awards presented on December 10th, the anniversary of Nobel’s death. (-H represents Honorary member, -R represents Retired member) # YEAR AWARD NAME AND SOCIETY DOB DECEASED 1 1904 PM Ivan Petrovich Pavlov (APS-H) 09/14/1849 02/27/1936 for work on the physiology of digestion, through which knowledge on vital aspects of the subject has been transformed and enlarged. 2 1912 PM Alexis Carrel (APS/ASIP) 06/28/1873 01/05/1944 for work on vascular suture and the transplantation of blood vessels and organs 3 1919 PM Jules Bordet (AAI-H) 06/13/1870 04/06/1961 for discoveries relating to immunity 4 1920 PM August Krogh (APS-H) 11/15/1874 09/13/1949 (Schack August Steenberger Krogh) for discovery of the capillary motor regulating mechanism 5 1922 PM A. V. Hill (APS-H) 09/26/1886 06/03/1977 Sir Archibald Vivial Hill for discovery relating to the production of heat in the muscle 6 1922 PM Otto Meyerhof (ASBMB) 04/12/1884 10/07/1951 (Otto Fritz Meyerhof) for discovery of the fixed relationship between the consumption of oxygen and the metabolism of lactic acid in the muscle 7 1923 PM Frederick Grant Banting (ASPET) 11/14/1891 02/21/1941 for the discovery of insulin 8 1923 PM John J.R. Macleod (APS) 09/08/1876 03/16/1935 (John James Richard Macleod) for the discovery of insulin 9 1926 C Theodor Svedberg (ASBMB-H) 08/30/1884 02/26/1971 for work on disperse systems 10 1930 PM Karl Landsteiner (ASIP/AAI) 06/14/1868 06/26/1943 for discovery of human blood groups 11 1931 PM Otto Heinrich Warburg (ASBMB-H) 10/08/1883 08/03/1970 for discovery of the nature and mode of action of the respiratory enzyme 12 1932 PM Lord Edgar D. -
Història De La Química
HISTÒRIA DE LA QUÍMICA Curs 2004-2005 Dimarts i dijous, de 13:00 a 14:00, dimecres de 12:00 a 13:00 Professor: Agustí Nieto Galan [email protected] CEHIC C1/-146 Hores de visita: dimarts (12-13 hr.) i dimecres (11-12 hr.) 1. Objectius del curs L’assignatura, adreçada sobretot als estudiants de química de la UAB, proporciona una reflexió humanística, en clau històrica, sobre els orígens i evolució continuada d'una de les branques fonamentals de la ciència moderna. Lluny de les velles històries que separaven la química en dues gran etapes ben diversificades (la precientífica dels alquimistes i els artesans, i la científica i moderna, la del progrés científic), es presenta aquí una química en constant recerca de la seva identitat, en crisi i evolució permanent (des de l’alquímia i la filosofia natural a la bioquímica dels nostres dies). L'assignatura intenta apropar a l'alumne als continguts elementals sobre la història de la química, en el marc general de la història de la ciència, i pretén contribuir a l'adquisició d'una sèrie d'habilitats relacionades amb el treball intel·lectual: lectura de textos històrico-científics, anàlisi biogràfica, reconstrucció d'experiments, expressió oral i escrita d'un discurs històric, etc. 2. Programa S’alternen les sessions d’exposició magistral del professor, amb exercicis pràctics (l’anàlisi de gravats antics, de textos de químics importants, o la reconstrucció històrica d'experiments o laboratoris). A l’hora de visita dels dimecres (11-12 hr.) el professor tutoritzarà una part del treball dels estudiants (estudi de Premis Nobel, exposicions, lectures complementàries, etc.) Els orígens 1. -
Recipients of Major Scientific Awards a Descriptive And
RECIPIENTS OF MAJOR SCIENTIFIC AWARDS A DESCRIPTIVE AND PREDICTIVE ANALYSIS by ANDREW CALVIN BARBEE DISSERTATION Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at The University of Texas at Arlington December 16, 2016 Arlington, Texas Supervising Committee: James C. Hardy, Supervising Professor Casey Graham Brown John P. Connolly Copyright © by Andrew Barbee 2016 All Rights Reserved ii ACKNOWLEDGEMENTS I would like to thank Dr. James Hardy for his willingness to serve on my committee when the university required me to restart the dissertation process. He helped me work through frustration, brainstorm ideas, and develop a meaningful study. Thank you to the other members of the dissertation committee, including Dr. Casey Brown and Dr. John Connolly. Also, I need to thank Andy Herzog with the university library. His willingness to locate needed resources, and provide insightful and informative research techniques was very helpful. I also want to thank Dr. Florence Haseltine with the RAISE project for communicating with me and sharing award data. And thank you, Dr. Hardy, for introducing me to Dr. Steven Bourgeois. Dr. Bourgeois has a gift as a teacher and is a humble and patient coach. I am thankful for his ability to stretch me without pulling a muscle. On a more personal note, I need to thank my father, Andy Barbee. He saw this day long before I did and encouraged me to pursue the doctorate. In addition, he was there during my darkest hour, this side of heaven, and I am eternally grateful for him. Thank you to our daughter Ana-Alicia. -
15.6 News & Views MH
NEWS & VIEWS NATURE|Vol 441|15 June 2006 ciple, that a technique that prevented the full OBITUARY characterization of synthetic intermediates could not give rise to authentic peptide prod- ucts. The objections of traditional chemists Bruce Merrifield (1921–2006) were ultimately refuted by the systematic Inventor of solid-phase peptide synthesis. development of improved solid-phase syn- thetic chemistry in Merrifield’s and other lab- oratories during the 1970s and 1980s, and by the emergence of powerful analytical tech- The death of Bruce Merrifield on 14 May 2006 niques for determining the structure and brings to a close the life of one of the most purity of synthetic peptides. The solid-phase original scientists of the second half of the method is now used routinely for the chemical twentieth century. Between 1959 and 1963, synthesis of peptides and proteins up to 50 or BETTMANN/CORBIS Merrifield revolutionized organic chemistry so amino acids in length. by his invention of solid-phase peptide syn- Today, the discovery of vast numbers of thesis. This “simple and ingenious” technique, potent peptide natural products is leading to a as it was described in the citation for Merri- resurgence in pharmaceutical research on field’s 1984 Nobel Prize in Chemistry, created peptides. Solid-phase synthesis is the unri- a paradigm shift in synthetic chemistry and valled technique for the preparation of such profoundly affected biomedical research. compounds in order to determine the chemi- Robert Bruce Merrifield was born in Fort cal basis of their biological function. Merri- Worth, Texas, on 15 July 1921, the only son of field’s ingenious concept led directly to the George and Lorene (Lucas) Merrifield. -
Chemistry of Drugs
Chemistry of Drugs DAVID E. NEWTON One Last Time . for John McArdle, Lee Nolet, Richard Olson, David Parr, David Rowand, Jeff Williams, and John D’Emilio Thanks for the memories! ◆ Chemistry of Drugs Copyright © 2007 by David E. Newton All rights reserved. No part of this book may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage or retrieval systems, without permission in writing from the publisher. For information contact: Facts On File, Inc. An imprint of Infobase Publishing 132 West 31st Street New York NY 10001 Library of Congress Cataloging-in-Publication Data Newton, David E. Chemistry of drugs / David E. Newton. p. cm—(The new chemistry) Includes bibliographical references and index ISBN-10: 0-8160-5276-X ISBN-13: 978-0-8160-5276-9 1. Pharmaceutical chemistry—Juvenile literature. 2. Drugs—Juvenile literature. I. Title RS403.N496 2007 615.'19—dc22 2006030004 Facts On File books are available at special discounts when purchased in bulk quantities for businesses, associations, institutions, or sales promotions. Please call our Special Sales Department in New York at (212) 967-8800 or (800) 322-8755. You can fi nd Facts On File on the World Wide Web at http://www.factsonfi le.com Text design by James Scotto-Lavino Illustrations by George Barille /Accurate Art, Inc. Project editing by Dorothy Cummings Printed in the United States of America MP FOF 10 9 8 7 6 5 4 3 2 1 This book is printed on acid-free paper. ◆ CONTENTS Preface vii Introduction -
The Impact of Nobel Prize in Chemistry on Fine Chemicals
MILESTONESFROM THE SCIENTIFIC IN CHEMISTRY ADVISORY BOARD Ian C. Lennon The impact of Nobel Prize in Chemistry on fine chemicals IAN C. LENNON Member of Chimica Oggi/Chemistry Today’s Scientific advisory board s this is the “2011: International Year of Chemistry” it is opportune to reflect on the impact that the Nobel Prize in Chemistry has had on the pharmaceuti- Acal and contract manufacturing industries. Between 1901 and 2010 the Nobel Prize in Chemistry has been awarded 102 times to 160 Nobel Laureates for achieve- ments in a diverse range of chemistry, from polymers to biological chemistry, struc- tural and surface Chemistry, to quantum mechanics. This editorial will focus on those Nobel Prizes that have had the biggest impact in the manufacture of pharmaceuti- cals and fine chemicals. By the start of the 20th Century chemical manufacturing was well establi- shed in Europe and many new reactions and techniques were being developed. The 1902 No- bel Prize in Chemistry awarded to Emil Fischer for his work on purine and sugar synthesis was hi- ghly significant. Fischer has >8 reactions named after him, including the Fischer Indole synthesis and the Fischer reduction. The 1912 prize was shared between Victor Grignard and Paul Sabatier. 2 We can all appreciate the impact of the Grignard reaction to enable the synthesis of alcohols and for- ming new carbon-carbon bonds, but Sabatier’s work on developing methods of hydrogenating organic compounds in the presence of finely disintegrated metals, was an equally important milestone in organic chemistry. A few industrial chemists would dispute the fundamental importance of Fritz Haber’s work on the synthesis of ammonia, which led to the 1918 prize, though awarded in 1919 as no candidate met the criteria to receive the award in 1918, so it was deferred for one year. -
24 August 2013 Seminar Held
PROCEEDINGS OF THE NOBEL PRIZE SEMINAR 2012 (NPS 2012) 0 Organized by School of Chemistry Editor: Dr. Nabakrushna Behera Lecturer, School of Chemistry, S.U. (E-mail: [email protected]) 24 August 2013 Seminar Held Sambalpur University Jyoti Vihar-768 019 Odisha Organizing Secretary: Dr. N. K. Behera, School of Chemistry, S.U., Jyoti Vihar, 768 019, Odisha. Dr. S. C. Jamir Governor, Odisha Raj Bhawan Bhubaneswar-751 008 August 13, 2013 EMSSSEM I am glad to know that the School of Chemistry, Sambalpur University, like previous years is organizing a Seminar on "Nobel Prize" on August 24, 2013. The Nobel Prize instituted on the lines of its mentor and founder Alfred Nobel's last will to establish a series of prizes for those who confer the “greatest benefit on mankind’ is widely regarded as the most coveted international award given in recognition to excellent work done in the fields of Physics, Chemistry, Physiology or Medicine, Literature, and Peace. The Prize since its introduction in 1901 has a very impressive list of winners and each of them has their own story of success. It is heartening that a seminar is being organized annually focusing on the Nobel Prize winning work of the Nobel laureates of that particular year. The initiative is indeed laudable as it will help teachers as well as students a lot in knowing more about the works of illustrious recipients and drawing inspiration to excel and work for the betterment of mankind. I am sure the proceeding to be brought out on the occasion will be highly enlightening. -
Nobel Laureates in Chemistry 1901-1992
Nobel Laureates in Chemistry 1901-1992 Laylin K. James, EDITOR Lafayette College History of Modern Chemical Sciences Jeffrey L. Sturchio, SERIBS EDITOR Merck & Co., Inc. 1993 American Chemical Society and the Chemical Heritage Foundation Contents Preface xv 1901 Jacobus van't Hoff 1 1902 Emil Fischer 8 1903 Svante Arrhenius 15 1904 William Ramsay 23 1905 Adolf von Baeyer 30 1906 Henri Moissan 35 1907 Eduard Buchner 42 1908 Ernest Rutherford 49 1909 Wilhelm Ostwald 61 1910 Otto Wallach 69 1911 Marie Curie 75 1912 Victor Grignard 83 1912 Paul Sabatier 88 1913 Alfred Werner 93 1914 Theodore William Richards 100 1915 Richard Martin Willstätter 108 1918 Fritz Haber 114 1920 Walther Hermann Nernst 125 1921 Frederick Soddy 134 1922 Francis William Aston 140 1923 Fritz Pregl 146 1925 Richard Zsigmondy 151 1926 The Svedberg 158 1927 Heinrich Wieland 164 1928 Adolf Windaus 169 1929 Hans von Euler-Chelpin 175 1929 Arthur Harden 181 1930 Hans Fischer 187 1931 Friedrich Bergius 192 1931 Carl Bosch 198 1932 Irving Langmuir 205 xi IIX öit' Mqn pjEim 096i 31t Ä>[SAOJÄ3H ABJSCXref 6561 9017 aaSues sptrapay 8S6T 66£ PP°1 smiaqoy japuexajv Z.S61 £6£ AOU9UI3S ipiASÄEJO^IJSI A?l05l!N 9S61 98e pooAvpusuiH IHÄ3 956T 08e pncauSiA HQ JUMUIA gg6I 89e SmpiBd pro snutq frS6I 6S€ jaSuiptiBjs UUBUU9H £S6I 95£ 3§uħ UOJ§UIJ|IJAJ aDuamtq pjEipr^j ^S6I 3S£ UUJEy\[ J3WOJ Uqof J311DJV 3S61 frK SaoqT^s uua^ ;g6t 8ee UBflWW uiAvpg IS6T 3ee SPKI ««B«U3H inEd °»o os6i 83£ J3PIV wn^ os6i 13€ anbnuiQ SIDUBJJ ureini^ 6t^6l Sie s™ps!l 3UJV 8fr6I 90e uosutqotf uaqotf Z.^61 00£ Asprejs -
Appendix the Nobel Prize in Chemistry
Appendix The Nobel Prize in Chemistry Alfred Bernard Nobel (1833-1896) amassed an enormous fortune from his inventions and improvements in the manufacture of explosives. His father was also an explosives manufacturer, and in 1863 Alfred developed a detonator based on mercury fulminate, which made possible the use of the liquid explosive nitroglycerine. Nobel continued his experiments in spite of an explosion in 1864 that destroyed the factory and killed five people including his younger brother. In 1867 he patented dynamite, in which nitroglycerine was absorbed by the inert solid kieselguhr and was therefore much safer to handle. In 1875 he introduced the more powerful blasting gelatin.e, in which the nitroglycerine was gelatinised with nitrocellulose. These inventions made possible major civil engineering projects like the Corinth canal and the St Gotthard tunnel. In 1887 Nobel introduced ballistite, a smokeless explosive for military use. Nobel hoped that the destructive capabilities of the new explosives would reduce the likelihood of war. Nobel left his fortune for the establishment of five prizes to be awarded annually for achievements in chemistry, physics, physiology or medicine, literature of an idealistic tendency, and the promotion of world peace. The rust awards were made in 1901. The Nobel Prize for Economics was founded in 1968 by the National Bank of Sweden and the rust award was made in 1969. The Nobel Prizes have become the most highly regarded of all international awards. A Prize cannot be shared by more than three people, and cannot be awarded posthumously. A list of the winners of the Nobel Prize for Chemistry is given below.